Carl S. Apstein - Publications

Affiliations: 
Boston University, Boston, MA, United States 
Area:
Animal Physiology Biology, Cell Biology

141 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2012 Selker HP, Beshansky JR, Sheehan PR, Massaro JM, Griffith JL, D'Agostino RB, Ruthazer R, Atkins JM, Sayah AJ, Levy MK, Richards ME, Aufderheide TP, Braude DA, Pirrallo RG, Doyle DD, ... ... Apstein CS, et al. Out-of-hospital administration of intravenous glucose-insulin-potassium in patients with suspected acute coronary syndromes: the IMMEDIATE randomized controlled trial. Jama. 307: 1925-33. PMID 22452807 DOI: 10.1001/Jama.2012.426  0.367
2012 Selker HP, Beshansky JR, Griffith JL, D'Agostino RB, Massaro JM, Udelson JE, Rashba EJ, Ruthazer R, Sheehan PR, Desvigne-Nickens P, Rosenberg YD, Atkins JM, Sayah AJ, Aufderheide TP, Rackley CE, ... ... Apstein CS, et al. Study design for the Immediate Myocardial Metabolic Enhancement During Initial Assessment and Treatment in Emergency Care (IMMEDIATE) Trial: A double-blind randomized controlled trial of intravenous glucose, insulin, and potassium for acute coronary syndromes in emergency medical services. American Heart Journal. 163: 315-22. PMID 22424000 DOI: 10.1016/J.Ahj.2012.02.002  0.435
2007 Tsang MW, Davidoff R, Korach A, Apstein CS, Hesselvik JF, Nguyen H, Shemin RJ, Shapira OM. Diastolic dysfunction after coronary artery bypass grafting--the effect of glucose-insulin-potassium infusion. Journal of Cardiac Surgery. 22: 185-91. PMID 17488411 DOI: 10.1111/J.1540-8191.2007.00382.X  0.363
2007 Podesser BK, Jain M, Ngoy S, Apstein CS, Eberli FR. Unveiling gender differences in demand ischemia: a study in a rat model of genetic hypertension. European Journal of Cardio-Thoracic Surgery : Official Journal of the European Association For Cardio-Thoracic Surgery. 31: 298-304. PMID 17175162 DOI: 10.1016/J.Ejcts.2006.10.041  0.414
2005 Apstein CS, Opie LH. A challenge to the metabolic approach to myocardial ischaemia. European Heart Journal. 26: 956-9. PMID 15797886 DOI: 10.1093/Eurheartj/Ehi200  0.378
2005 Trueblood NA, Inscore PR, Brenner D, Lugassy D, Apstein CS, Sawyer DB, Colucci WS. Biphasic temporal pattern in exercise capacity after myocardial infarction in the rat: relationship to left ventricular remodeling. American Journal of Physiology. Heart and Circulatory Physiology. 288: H244-9. PMID 15358607 DOI: 10.1152/Ajpheart.00042.2004  0.42
2004 Brenner DA, Jain M, Pimentel DR, Wang B, Connors LH, Skinner M, Apstein CS, Liao R. Human amyloidogenic light chains directly impair cardiomyocyte function through an increase in cellular oxidant stress. Circulation Research. 94: 1008-10. PMID 15044325 DOI: 10.1161/01.Res.0000126569.75419.74  0.368
2004 Lazar HL, Chipkin SR, Fitzgerald CA, Bao Y, Cabral H, Apstein CS. Tight glycemic control in diabetic coronary artery bypass graft patients improves perioperative outcomes and decreases recurrent ischemic events. Circulation. 109: 1497-502. PMID 15006999 DOI: 10.1161/01.Cir.0000121747.71054.79  0.308
2004 Jain M, Cui L, Brenner DA, Wang B, Handy DE, Leopold JA, Loscalzo J, Apstein CS, Liao R. Increased myocardial dysfunction after ischemia-reperfusion in mice lacking glucose-6-phosphate dehydrogenase. Circulation. 109: 898-903. PMID 14757696 DOI: 10.1161/01.Cir.0000112605.43318.Ca  0.448
2003 Saupe KW, Sobol SC, Koh SG, Apstein CS. Effects of AT1 receptor block begun late in life on normal cardiac aging in rats. Journal of Cardiovascular Pharmacology. 42: 573-80. PMID 14508245 DOI: 10.1097/00005344-200310000-00017  0.423
2003 Apstein CS. The benefits of glucose-insulin-potassium for acute myocardial infarction (and some concerns). Journal of the American College of Cardiology. 42: 792-5. PMID 12957422 DOI: 10.1016/S0735-1097(03)00844-1  0.37
2003 Koh SG, Brenner DA, Korzick DH, Tickerhoof MM, Apstein CS, Saupe KW. Exercise intolerance during post-MI heart failure in rats: prevention with supplemental dietary propionyl-L-carnitine. Cardiovascular Drugs and Therapy / Sponsored by the International Society of Cardiovascular Pharmacotherapy. 17: 7-14. PMID 12843682 DOI: 10.1023/A:1024247507014  0.386
2003 Jain M, Brenner DA, Cui L, Lim CC, Wang B, Pimentel DR, Koh S, Sawyer DB, Leopold JA, Handy DE, Loscalzo J, Apstein CS, Liao R. Glucose-6-phosphate dehydrogenase modulates cytosolic redox status and contractile phenotype in adult cardiomyocytes. Circulation Research. 93: e9-16. PMID 12829617 DOI: 10.1161/01.Res.0000083489.83704.76  0.342
2003 Ekery DL, Davidoff R, Orlandi QG, Apstein CS, Hesselvik JF, Shemin RJ, Shapira OM. Imaging and diagnostic testing: diastolic dysfunction after coronary artery bypass grafting: a frequent finding of clinical significance not influenced by intravenous calcium. American Heart Journal. 145: 896-902. PMID 12766750 DOI: 10.1016/S0002-8703(02)94786-1  0.35
2003 Piña IL, Apstein CS, Balady GJ, Belardinelli R, Chaitman BR, Duscha BD, Fletcher BJ, Fleg JL, Myers JN, Sullivan MJ. Exercise and heart failure: A statement from the American Heart Association Committee on exercise, rehabilitation, and prevention. Circulation. 107: 1210-25. PMID 12615804 DOI: 10.1161/01.Cir.0000055013.92097.40  0.301
2003 Varma N, Morgan JP, Apstein CS. Mechanisms underlying ischemic diastolic dysfunction: relation between rigor, calcium homeostasis, and relaxation rate. American Journal of Physiology. Heart and Circulatory Physiology. 284: H758-71. PMID 12414440 DOI: 10.1152/Ajpheart.00286.2002  0.346
2002 Jain M, Liao R, Podesser BK, Ngoy S, Apstein CS, Eberli FR. Influence of gender on the response to hemodynamic overload after myocardial infarction. American Journal of Physiology. Heart and Circulatory Physiology. 283: H2544-50. PMID 12388328 DOI: 10.1152/Ajpheart.00338.2002  0.428
2002 Sawyer DB, Suter TM, Apstein CS. The sting of salt on an old, but open, wound--is Na(+) the cause of mitochondrial and myocardial injury during ischemia/reperfusion? Journal of Molecular and Cellular Cardiology. 34: 699-702. PMID 12099708 DOI: 10.1006/Jmcc.2002.2030  0.358
2001 Sam F, Sawyer DB, Xie Z, Chang DLF, Ngoy S, Brenner DA, Siwik DA, Singh K, Apstein CS, Colucci WS. Mice lacking inducible nitric oxide synthase have improved left ventricular contractile function and reduced apoptotic cell death late after myocardial infarction Circulation Research. 89: 351-356. PMID 11509452 DOI: 10.1161/Hh1601.094993  0.38
2001 Brenner DA, Apstein CS, Saupe KW. Exercise training attenuates age-associated diastolic dysfunction in rats. Circulation. 104: 221-6. PMID 11447090 DOI: 10.1161/01.Cir.104.2.221  0.367
2001 Varma N, Eberli FR, Apstein CS. Left ventricular diastolic dysfunction during demand ischemia: rigor underlies increased stiffness without calcium-mediated tension. Amelioration by glycolytic substrate. Journal of the American College of Cardiology. 37: 2144-53. PMID 11419901 DOI: 10.1016/S0735-1097(01)01282-7  0.376
2001 Trueblood NA, Xie Z, Communal C, Sam F, Ngoy S, Liaw L, Jenkins AW, Wang J, Sawyer DB, Bing OHL, Apstein CS, Colucci WS, Singh K. Exaggerated left ventricular dilation and reduced collagen deposition after myocardial infarction in mice lacking osteopontin Circulation Research. 88: 1080-1087. PMID 11375279 DOI: 10.1161/Hh1001.090842  0.42
2001 Jain M, DerSimonian H, Brenner DA, Ngoy S, Teller P, Edge AS, Zawadzka A, Wetzel K, Sawyer DB, Colucci WS, Apstein CS, Liao R. Cell therapy attenuates deleterious ventricular remodeling and improves cardiac performance after myocardial infarction. Circulation. 103: 1920-7. PMID 11294813 DOI: 10.1161/01.Cir.103.14.1920  0.491
2001 Guazzi M, Brenner DA, Apstein CS, Saupe KW. Exercise intolerance in rats with hypertensive heart disease is associated with impaired diastolic relaxation. Hypertension. 37: 204-8. PMID 11230272 DOI: 10.1161/01.Hyp.37.2.204  0.366
2001 Podesser BK, Siwik DA, Eberli FR, Sam F, Ngoy S, Lambert J, Ngo K, Apstein CS, Colucci WS. ETA-receptor blockade prevents matrix metalloproteinase activation late postmyocardial infarction in the rat American Journal of Physiology - Heart and Circulatory Physiology. 280. PMID 11179039 DOI: 10.1152/Ajpheart.2001.280.3.H984  0.346
2001 Saupe KW, Eberli FR, Ingwall JS, Apstein CS. Metabolic support as an adjunct to inotropic support in the hypoperfused heart. Journal of Molecular and Cellular Cardiology. 33: 261-9. PMID 11162131 DOI: 10.1006/Jmcc.2000.1297  0.478
2001 Liao R, Jain M, Teller P, Connors LH, Ngoy S, Skinner M, Falk RH, Apstein CS. Infusion of Light Chains From Patients With Cardiac Amyloidosis Causes Diastolic Dysfunction in Isolated Mouse Hearts Circulation. 104: 1594-1597. DOI: 10.1161/Circ.104.14.1594  0.42
2000 Eberli FR, Strömer H, Ferrell MA, Varma N, Morgan JP, Neubauer S, Apstein CS. Lack of direct role for calcium in ischemic diastolic dysfunction in isolated hearts. Circulation. 102: 2643-9. PMID 11085969 DOI: 10.1161/01.Cir.102.21.2643  0.377
2000 Nagata K, Communal C, Lim CC, Jain M, Suter TM, Eberli FR, Satoh N, Colucci WS, Apstein CS, Liao R. Altered β-adrenergic signal transduction in nonfailing hypertrophied myocytes from Dahl salt-sensitive rats American Journal of Physiology - Heart and Circulatory Physiology. 279. PMID 11045988 DOI: 10.1152/Ajpheart.2000.279.5.H2502  0.318
2000 Lim CC, Apstein CS, Colucci WS, Liao R. Impaired cell shortening and relengthening with increased pacing frequency are intrinsic to the senescent mouse cardiomyocyte Journal of Molecular and Cellular Cardiology. 32: 2075-2082. PMID 11040110 DOI: 10.1006/Jmcc.2000.1239  0.342
2000 Lazar HL, Chipkin S, Philippides G, Bao Y, Apstein C. Glucose-insulin-potassium solutions improve outcomes in diabetics who have coronary artery operations. The Annals of Thoracic Surgery. 70: 145-150. PMID 10921699 DOI: 10.1016/S0003-4975(00)01317-5  0.364
2000 Sam F, Sawyer DB, Chang DLF, Eberli FR, Ngoy S, Jain M, Amin J, Apstein CS, Colucci WS. Progressive left ventricular remodeling and apoptosis late after myocardial infarction in mouse heart American Journal of Physiology - Heart and Circulatory Physiology. 279. PMID 10899082 DOI: 10.1152/Ajpheart.2000.279.1.H422  0.522
2000 Saupe KW, Lim CC, Ingwall JS, Apstein CS, Eberli FR. Comparison of hearts with 2 types of pressure-overload left ventricular hypertrophy. Hypertension. 35: 1167-72. PMID 10818082 DOI: 10.1161/01.Hyp.35.5.1167  0.491
2000 Varma N, Eberli FR, Apstein CS. Increased diastolic chamber stiffness during demand ischemia: response to quick length change differentiates rigor-activated from calcium-activated tension. Circulation. 101: 2185-92. PMID 10801760 DOI: 10.1161/01.Cir.101.18.2185  0.413
2000 Cave AC, Ingwall JS, Friedrich J, Liao R, Saupe KW, Apstein CS, Eberli FR. ATP synthesis during low-flow ischemia: influence of increased glycolytic substrate. Circulation. 101: 2090-6. PMID 10790352 DOI: 10.1161/01.Cir.101.17.2090  0.451
2000 Jain M, Liao R, Ngoy S, Whittaker P, Apstein CS, Eberli FR. Angiotensin II receptor blockade attenuates the deleterious effects of exercise training on post-MI ventricular remodelling in rats. Cardiovascular Research. 46: 66-72. PMID 10727654 DOI: 10.1016/S0008-6363(99)00429-0  0.432
2000 Apstein CS. Increased glycolytic substrate protection improves ischemic cardiac dysfunction and reduces injury. American Heart Journal. 139. PMID 10650323 DOI: 10.1067/Mhj.2000.103920  0.446
1999 Lim CC, Liao R, Varma N, Apstein CS. Impaired lusitropy-frequency in the aging mouse: role of Ca(2+)-handling proteins and effects of isoproterenol. The American Journal of Physiology. 277: H2083-90. PMID 10564164 DOI: 10.1152/Ajpheart.1999.277.5.H2083  0.327
1999 McKenney PA, Apstein CS, Mendes LA, Connelly GP, Aldea GS, Shemin RJ, Davidoff R. Immediate effect of aortic valve replacement for aortic stenosis on left ventricular diastolic chamber stiffness American Journal of Cardiology. 84: 914-918. PMID 10532510 DOI: 10.1016/S0002-9149(99)00465-8  0.351
1999 Apstein CS, Opie LH. Glucose-insulin-potassium (GIK) for acute myocardial infarction: a negative study with a positive value. Cardiovascular Drugs and Therapy. 13: 185-189. PMID 10439880 DOI: 10.1023/A:1007757407246  0.32
1999 Saupe KW, Eberli FR, Ingwall JS, Apstein CS. Hypoperfusion-induced contractile failure does not require changes in cardiac energetics. The American Journal of Physiology. 276: H1715-23. PMID 10330258 DOI: 10.1152/Ajpheart.1999.276.5.H1715  0.465
1998 Apstein CS. Glucose-insulin-potassium for acute myocardial infarction: remarkable results from a new prospective, randomized trial Circulation. 98: 2223-2226. PMID 9826307 DOI: 10.1161/01.Cir.98.21.2223  0.349
1998 Eberli FR, Sam F, Ngoy S, Apstein CS, Colucci WS. Left-ventricular structural and functional remodeling in the mouse after myocardial infarction: Assessment with the isovolumetrically-contracting Langendorff heart Journal of Molecular and Cellular Cardiology. 30: 1443-1447. PMID 9710811 DOI: 10.1006/Jmcc.1998.0702  0.544
1998 Nagata K, Liao R, Eberli FR, Satoh N, Chevalier B, Apstein CS, Suter TM. Early changes in excitation-contraction coupling: transition from compensated hypertrophy to failure in Dahl salt-sensitive rat myocytes Cardiovascular Research. 37: 467-477. PMID 9614501 DOI: 10.1016/S0008-6363(97)00278-2  0.398
1998 Jain M, Podessor BK, Liao R, Ngoy S, Apstein CS, Eberli FR. Hypertension following myocardial infarction causes increased LV dilation and heart failure Journal of Cardiac Failure. 4: 14. DOI: 10.1016/S1071-9164(98)90053-7  0.501
1998 Jain M, Liao R, Ngoy S, Apstein CS, Eberli FR. Gender and hypertension independently influence susceptibility to ischemia-reperfusion injury post-myocardial infarction Journal of Cardiac Failure. 4: 14. DOI: 10.1016/S1071-9164(98)90052-5  0.436
1998 Jain M, Liao R, Ngoy S, Apstein CS, Eberli FR. Hypertension post-myocardial infarction causes additional deleterious remodeling in males versus females Journal of Cardiac Failure. 4: 14. DOI: 10.1016/S1071-9164(98)90051-3  0.385
1998 Lim C, Liao R, Varma N, Suter TM, Apstein CS. Decreased contractility in response to increased heart rate in the senescent mouse heart Journal of Cardiac Failure. 4: 13. DOI: 10.1016/S1071-9164(98)90048-3  0.398
1998 Sam F, Sawyer DB, Ngoy S, Siwik DA, Apstein CS, Colucci WS. Absence of NOS2 does not affect cell death, infarct size or early ventricular remodeling in the infarcted mouse Journal of Cardiac Failure. 4: 10. DOI: 10.1016/S1071-9164(98)90038-0  0.433
1998 Guazzi M, Jain M, Liao R, Suter T, Brenner DA, Ngoy S, Colucci WS, Apstein CS. Exercise intolerance due to increased left ventricular diastolic chamber stiffness in rats with hypertensive hypertrophy Journal of Cardiac Failure. 4: 10. DOI: 10.1016/S1071-9164(98)90036-7  0.377
1998 Sam F, Sawyer DB, Eberli FR, Chang DL, Ngoy S, Apstein CS, Colucci WS. Increased cell death coincides with remodeling late after myocardial infarction in the mouse Journal of Cardiac Failure. 4: 10. DOI: 10.1016/S1071-9164(98)90035-5  0.482
1998 Eberli F, Sam F, Ngoy S, Chang D, Apstein C, Colucci W. Progressive molecular and physiologic remodeling in murine hearts after myocardial infarction Journal of the American College of Cardiology. 31: 288. DOI: 10.1016/S0735-1097(98)81897-4  0.504
1998 Sam F, Eberli F, Ngoy S, Sivvik D, Chang D, Apstein C, Colucci W. Expression of the inducible isoform of nitric oxide synthase in murine myocardium following a myocardial infarction Journal of the American College of Cardiology. 31: 187. DOI: 10.1016/S0735-1097(98)81453-8  0.383
1998 Orlandi QG, Davidoff R, Aldea GS, Apstein CS, Pimental D, Hesselvik JF, Shemin RJ, Shapira OM. Diastolic dysfunction post coronary artery bypass grafting: a consistent finding of clinical relevance Journal of the American College of Cardiology. 31: 426. DOI: 10.1016/S0735-1097(98)80198-8  0.324
1998 Podesser BK, Apstein CS, Ngoy S, Jain M, Eberti FR. Hypertension induced left ventricular hypertrophy in females is associated with reduced tolerance to ischemia and reperfusion Journal of the American College of Cardiology. 31: 409. DOI: 10.1016/S0735-1097(98)80122-8  0.441
1998 Sam F, Ruidera J, Ngoy S, Suter T, Colucci W, Apstein C, Eberli F. Beneficial effects during ischemia-reperfusion: synergistic action of levosimendan and dobutamine Journal of the American College of Cardiology. 31: 279. DOI: 10.1016/S0735-1097(97)84924-8  0.389
1997 Cave AC, Silverman AS, Apstein CS. Ischemic Preconditioning Does Not Protect Against Contractile Dysfunction in the Presence of Residual Flow Studies in the Isolated, Blood-Perfused Rat Heart Circulation. 96: 3087-3093. PMID 9386179 DOI: 10.1161/01.Cir.96.9.3087  0.418
1997 Apstein CS, Taegtmeyer H. Glucose-Insulin-Potassium in Acute Myocardial Infarction The Time Has Come for a Large, Prospective Trial Circulation. 96: 1074-1077. PMID 9286931 DOI: 10.1161/01.Cir.96.4.1074  0.368
1997 Libonati JR, Eberli FR, Sesselberg HW, Apstein CS. Effects of low-flow ischemia on the positive inotropic action of angiotensin II in isolated rabbit and rat hearts. Cardiovascular Research. 33: 71-81. PMID 9059530 DOI: 10.1016/S0008-6363(96)00185-X  0.353
1997 Lazar HL, Philippides G, Fitzgerald C, Lancaster D, Shemin RJ, Apstein C. Glucose-insulin-potassium solutions enhance recovery after urgent coronary artery bypass grafting ☆ ☆☆ ★ ★★ The Journal of Thoracic and Cardiovascular Surgery. 113: 354-362. PMID 9040630 DOI: 10.1016/S0022-5223(97)70333-7  0.347
1996 Brooks WW, Apstein CS. Effect of treppe on isovolumic function in the isolated blood-perfused mouse heart. Journal of Molecular and Cellular Cardiology. 28: 1817-1822. PMID 8877791 DOI: 10.1006/Jmcc.1996.0171  0.478
1996 Bernstein EA, Eberli FR, Silverman AM, Horowitz GL, Apstein CS. Beneficial effects of felodipine on myocardial and coronary function during low-flow ischemia and reperfusion. Cardiovascular Drugs and Therapy. 10: 167-178. PMID 8842509 DOI: 10.1007/Bf00823595  0.494
1996 Cave AC, Apstein CS. Polymyxin B, a Protein Kinase C Inhibitor, Abolishes Preconditioning-induced Protection against Contractile Dysfunction in the Isolated Blood Perfused Rat Heart Journal of Molecular and Cellular Cardiology. 28: 977-987. PMID 8762036 DOI: 10.1006/Jmcc.1996.0091  0.435
1996 Varma N, Eberli FR, Apstein CS. Myocardial stunning can occur during acute hibernation Journal of the American College of Cardiology. 27: 365. DOI: 10.1016/S0735-1097(96)82598-8  0.414
1996 Libonati JR, Apstein CS, Ngoy S, Sessleberg HW, Herrick B, Eberli FR. No effect of angiotensin II on ischemic diastolic dysfunction in hypertrophied and infarcted rat hearts Journal of the American College of Cardiology. 27: 140. DOI: 10.1016/S0735-1097(96)80780-7  0.462
1996 Varma N, Eberli FR, Apstein CS. Increased diastolic chamber stiffness occurring during supply, demand, and zero-flow ischemia is determined by common subcellular mechanisms Journal of the American College of Cardiology. 27: 140. DOI: 10.1016/S0735-1097(96)80779-0  0.35
1996 Brooks WW, Conrad CH, Hayes JA, Apstein CS. Effect of isoproterenol induced fibrosis on left ventricular function in the isolated blood perfused mouse heart Journal of the American College of Cardiology. 27: 86. DOI: 10.1016/S0735-1097(96)80548-1  0.459
1995 Friedrich J, Apstein CS, Ingwall JS. 31P nuclear magnetic resonance spectroscopic imaging of regions of remodeled myocardium in the infarcted rat heart. Circulation. 92: 3527-38. PMID 8521576 DOI: 10.1161/01.Cir.92.12.3527  0.468
1995 Libonati JR, Apstein CS, Ngoy S, Sesselberg H, Herrick B, Balady G, Dempsey A, Davidoff R, Eberli FR. EXERCISE TRAINING FOLLOWING MYOCARDIAL INFARCTION DOES NOT ADVERSELY AFFECT LEFT VENTRICULAR GEOMETRY OR FUNCTION. Medicine & Science in Sports & Exercise. 27: S157. DOI: 10.1249/00005768-199505001-00885  0.43
1995 McKenney PA, Davidoff R, Mendes LA, Connelly GP, Aldea GS, Shemin RJ, Apstein CS. 1019-28 Retrograde Cardioplegia Increases Diastolic Chamber Stiffness After Coronary Artery Bypass Surgery Journal of the American College of Cardiology. 25: 396. DOI: 10.1016/0735-1097(95)93100-Q  0.359
1995 Varma N, Eberli FR, Apstein CS. 901-91 Diastolic Dysfunction During Demand Ischemia is due to a Reversible Rigor Force and is not a Calcium (Ca2+) Activated Tension Journal of the American College of Cardiology. 25: 27. DOI: 10.1016/0735-1097(95)91568-I  0.343
1994 McKenney PA, Apstein CS, Mendes LA, Connelly GP, Aldea GS, Shemin RJ, Davidoff R. Increased left ventricular diastolic chamber stiffness immediately after coronary artery bypass surgery Journal of the American College of Cardiology. 24: 1189-1194. PMID 7930238 DOI: 10.1016/0735-1097(94)90097-3  0.421
1994 Cave AC, Horowitz GL, Apstein CS. Can ischemic preconditioning protect against hypoxia-induced damage? Studies of contractile function in isolated perfused rat hearts. Journal of Molecular and Cellular Cardiology. 26: 1471-1486. PMID 7897671 DOI: 10.1006/Jmcc.1994.1166  0.446
1993 Plehn JF, Foster E, Grice WN, Huntington-Coats M, Apstein CS. Echocardiographic assessment of LV mass in rabbits: models of pressure and volume overload hypertrophy American Journal of Physiology-Heart and Circulatory Physiology. 265. PMID 8285245 DOI: 10.1152/Ajpheart.1993.265.6.H2066  0.333
1992 Mochizuki T, Eberli FR, Apstein CS, Lorell BH. Exacerbation of ischemic dysfunction by angiotensin II in red cell-perfused rabbit hearts. Effects on coronary flow, contractility, and high-energy phosphate metabolism. Journal of Clinical Investigation. 89: 490-498. PMID 1737839 DOI: 10.1172/Jci115611  0.466
1992 Connelly CM, Ngoy S, Schoen FJ, Apstein CS. Biomechanical properties of reperfused transmural myocardial infarcts in rabbits during the first week after infarction: Implications for left ventricular rupture Circulation Research. 71: 401-413. PMID 1628396 DOI: 10.1161/01.Res.71.2.401  0.498
1992 Knowlton AA, Connelly CM, Romo GM, Mamuya W, Apstein CS, Brecher P, Ngoy S. Rapid expression of fibronectin in the rabbit heart after myocardial infarction with and without reperfusion Journal of Clinical Investigation. 89: 1060-1068. PMID 1556175 DOI: 10.1172/Jci115685  0.443
1992 Frohlich ED, Apstein C, Chobanian AV, Devereux RB, Dustan HP, Dzau V, Fauad-Tarazi F, Horan MJ, Marcus M, Massie B, Pfeffer MA, Re RN, Roccella EJ, Savage D, Shub C. The heart in hypertension. The New England Journal of Medicine. 327: 998-1008. PMID 1518549 DOI: 10.1056/Nejm199210013271406  0.454
1992 Foster E, Plehn JF, Bernard SA, Battinelli NJ, Huntington-Coats M, Apstein CS. Regression of left ventricular hypertrophy in "Previously untreated" hypertensive blacks after 6 months of blood pressure reduction with alpha- and beta-adrenergic blockade and thiazide therapy Cardiovascular Drugs and Therapy. 6: 147-151. PMID 1390327 DOI: 10.1007/Bf00054563  0.301
1992 Eberli FR, Apstein CS, Ngoy S, Lorell BH. Exacerbation of left ventricular ischemic diastolic dysfunction by pressure-overload hypertrophy. Modification by specific inhibition of cardiac angiotensin converting enzyme. Circulation Research. 70: 931-943. PMID 1314716 DOI: 10.1161/01.Res.70.5.931  0.54
1991 Connelly CM, McLaughlin RJ, Vogel WM, Apstein CS. Reversible and irreversible elongation of ischemic, infarcted, and healed myocardium in response to increases in preload and afterload. Circulation. 84: 387-99. PMID 2060109 DOI: 10.1161/01.Cir.84.1.387  0.461
1991 Eberli FR, Weinberg EO, Grice WN, Horowitz GL, Apstein CS. Protective effect of increased glycolytic substrate against systolic and diastolic dysfunction and increased coronary resistance from prolonged global underperfusion and reperfusion in isolated rabbit hearts perfused with erythrocyte suspensions. Circulation Research. 68: 466-481. PMID 1991351 DOI: 10.1161/01.Res.68.2.466  0.505
1991 Knowlton AA, Brecher P, Apstein CS. Rapid expression of heat shock protein in the rabbit after brief cardiac ischemia Journal of Clinical Investigation. 87: 139-147. PMID 1985091 DOI: 10.1172/Jci114963  0.408
1991 Knowlton AA, Eberli FR, Brecher P, Romo GM, Owen A, Apstein CS, Ngoy S. A single myocardial stretch or decreased systolic fiber shortening stimulates the expression of heat shock protein 70 in the isolated, erythrocyte-perfused rabbit heart Journal of Clinical Investigation. 88: 2018-2025. PMID 1752959 DOI: 10.1172/Jci115529  0.43
1991 Konishi T, Apstein CS. Deleterious effects of digitalis on newborn rabbit myocardium after simulated cardiac surgery. The Journal of Thoracic and Cardiovascular Surgery. 101: 337-341. DOI: 10.1016/S0022-5223(19)36769-8  0.452
1991 Apstein CS. Tolerance of hypertrophied hearts to ischemia and hypoxia Journal of Molecular and Cellular Cardiology. 23. DOI: 10.1016/0022-2828(91)91377-4  0.468
1990 Lorell BH, Apstein CS, Cunningham MJ, Schoen FJ, Weinberg EO, Peeters GA, Barry WH. Contribution of endothelial cells to calcium-dependent fluorescence transients in rabbit hearts loaded with indo 1. Circulation Research. 67: 415-25. PMID 2376080 DOI: 10.1161/01.Res.67.2.415  0.35
1990 Schunkert H, Dzau VJ, Tang SS, Hirsch AT, Apstein CS, Lorell BH. Increased rat cardiac angiotensin converting enzyme activity and mRNA expression in pressure overload left ventricular hypertrophy. Effects on coronary resistance, contractility, and relaxation. Journal of Clinical Investigation. 86: 1913-1920. PMID 2174912 DOI: 10.1172/Jci114924  0.48
1990 Lorell BH, Apstein CS, Weinberg EO, Cunningham MJ. Diastolic function in left ventricular hypertrophy: clinical and experimental relationships. European Heart Journal. 11: 54-64. PMID 2150037 DOI: 10.1093/Eurheartj/11.Suppl_G.54  0.478
1990 Gaasch WH, Zile MR, Hoshino PK, Weinberg EO, Rhodes DR, Apstein CS. Tolerance of the hypertrophic heart to ischemia. Studies in compensated and failing dog hearts with pressure overload hypertrophy. Circulation. 81: 1644-1653. PMID 2139593 DOI: 10.1161/01.Cir.81.5.1644  0.508
1990 Cunningham MJ, Apstein CS, Weinberg EO, Vogel WM, Lorell BH. Influence of glucose and insulin on the exaggerated diastolic and systolic dysfunction of hypertrophied rat hearts during hypoxia. Circulation Research. 66: 406-415. PMID 2137038 DOI: 10.1161/01.Res.66.2.406  0.44
1990 Gaasch WH, Zile MR, Apstein CS. Glycolytic flux and the tolerance to ischemic arrest in hypertrophied-failing canine hearts Journal of the American College of Cardiology. 15. DOI: 10.1016/0735-1097(90)92740-S  0.433
1990 Eberli FR, Ferrell MA, Apstein CS. Failure of calcium overload to exacerbate ischemia and hypoxia induced diastolic contracture Journal of the American College of Cardiology. 15. DOI: 10.1016/0735-1097(90)91757-L  0.356
1989 Knowlton AA, Apstein CS, Saouf R, Brecher P. Leakage of heart fatty acid binding protein with ischemia and reperfusion in the rat Journal of Molecular and Cellular Cardiology. 21: 577-583. PMID 2778809 DOI: 10.1016/0022-2828(89)90823-7  0.427
1989 Connelly CM, Leppo JA, Weitzman PW, Vogel WM, Apstein CS. Effect of coronary occlusion and reperfusion on myocardial blood flow during infarct healing American Journal of Physiology - Heart and Circulatory Physiology. 257. PMID 2764125 DOI: 10.1152/Ajpheart.1989.257.2.H365  0.464
1989 Isoyama S, Lorell BH, Grice WN, Apstein CS. Contrast Effects Of Isoproterenol And Ouabain On Left Ventricular Diastolic Relaxation Dysfunction In Isolated, Blood-Perfused Rabbit Hearts Japanese Circulation Journal-English Edition. 53: 261-269. PMID 2746841 DOI: 10.1253/Jcj.53.261  0.498
1989 Wexler LF, Grice WN, Huntington M, Plehn JF, Apstein CS. Coronary Hypertension and Diastolic Compliance in Isolated Rabbit Hearts Hypertension. 13: 598-606. PMID 2737708 DOI: 10.1161/01.Hyp.13.6.598  0.476
1989 Lorell BH, Grice WN, Apstein CS. Influence of hypertension with minimal hypertrophy on diastolic function during demand ischemia. Hypertension. 13: 361-370. PMID 2522416 DOI: 10.1161/01.Hyp.13.4.361  0.505
1989 Gaasch WH, Zile MR, Hoshino PK, Apstein CS, Blaustein AS. Stress-shortening relations and myocardial blood flow in compensated and failing canine hearts with pressure-overload hypertrophy. Circulation. 79: 872-883. PMID 2522357 DOI: 10.1161/01.Cir.79.4.872  0.415
1989 Konishi T, Apstein CS. Comparison of three cardioplegic solutions during hypothermic ischemic arrest in neonatal blood-perfused rabbit hearts. The Journal of Thoracic and Cardiovascular Surgery. 98: 1132-1137. DOI: 10.1016/S0022-5223(19)34330-2  0.403
1988 Lorell BH, Isoyama S, Grice WN, Weinberg EO, Apstein CS. Effects of ouabain and isoproterenol on left ventricular diastolic function during low-flow ischemia in isolated, blood-perfused rabbit hearts. Circulation Research. 63: 457-467. PMID 3396161 DOI: 10.1161/01.Res.63.2.457  0.545
1988 Vogel WM, Apstein CS. Effects of alloxan-induced diabetes on ischemia-reperfusion injury in rabbit hearts Circulation Research. 62: 975-982. PMID 3359580 DOI: 10.1161/01.Res.62.5.975  0.37
1988 Wexler LF, Lorell BH, Momomura SI, Weinberg EO, Ingwall JS, Apstein CS. Enhanced sensitivity to hypoxia-induced diastolic dysfunction in pressure-overload left ventricular hypertrophy in the rat: Role of high-energy phosphate depletion Circulation Research. 62: 766-775. PMID 2964946 DOI: 10.1161/01.Res.62.4.766  0.48
1987 Przyklenk K, Connelly CM, McLaughlin RJ, Kloner RA, Apstein CS. Effect of myocyte necrosis on strength, strain, and stiffness of isolated myocardial strips. American Heart Journal. 114: 1349-59. PMID 3687688 DOI: 10.1016/0002-8703(87)90536-9  0.441
1987 Isoyama S, Apstein CS, Wexler LF, Grice WN, Lorell BH. Acute decrease in left ventricular diastolic chamber distensibility during simulated angina in isolated hearts. Circulation Research. 61: 925-933. PMID 3677344 DOI: 10.1161/01.Res.61.6.925  0.532
1987 Vogel WM, Hsia JC, Briggs LL, Er SS, Cassidy G, Apstein CS, Valeri CR. Reduced coronary vasoconstrictor activity of hemoglobin solutions purified by ATP-agarose affinity chromatography. Life Sciences. 41: 89-93. PMID 3600177 DOI: 10.1016/0024-3205(87)90560-1  0.36
1987 Apstein CS, Grossman W. Opposite initial effects of supply and demand ischemia on left ventricular diastolic compliance: the ischemia-diastolic paradox. Journal of Molecular and Cellular Cardiology. 19: 119-128. PMID 3550105 DOI: 10.1016/S0022-2828(87)80551-5  0.497
1987 Zile MR, Neill WA, Gaasch WH, Oxendine J, Apstein CS, Weinberg E, Bing OHL. Distribution of a neutral cardioplegic vehicle during the development of ischemic myocardial contracture Journal of Molecular and Cellular Cardiology. 19: 977-989. PMID 2449532 DOI: 10.1016/S0022-2828(87)80570-9  0.484
1987 Konishi T, Grice WN, Apstein CS. Effect of ouabain on recovery from hypothermic ischemic arrest in neonatal bloodperfused hearts Journal of Molecular and Cellular Cardiology. 19. DOI: 10.1016/S0022-2828(87)80833-7  0.423
1987 Konishi T, Knowlton AA, Grice WN, Apstein CS. Brief periods of repetitive reperfusion increase reperfusion Journal of Molecular and Cellular Cardiology. 19. DOI: 10.1016/S0022-2828(87)80825-8  0.407
1987 Lorell BH, Grice WN, Apstein CS. Which is more sensitive to ischemia, contractility or relaxation Journal of Molecular and Cellular Cardiology. 19. DOI: 10.1016/S0022-2828(87)80824-6  0.364
1987 Grice WN, Vogel WM, Apstein CS. Benefits of reperfusion in ischemic hypertrophied myocardium Journal of Molecular and Cellular Cardiology. 19. DOI: 10.1016/S0022-2828(87)80822-2  0.444
1987 Lorell BH, Grice WN, Apstein CS. Effects of demand ischemia on relaxation in isolated hypertrophied rabbit hearts Journal of Molecular and Cellular Cardiology. 19. DOI: 10.1016/S0022-2828(87)80821-0  0.447
1986 Wexler LF, Weinberg EO, Ingwall JS, Apstein CS. Acute alterations in diastolic left ventricular chamber distensibility: Mechanistic differences between hypoxemia and ischemia in isolated perfused rabbit and rat hearts Circulation Research. 59: 515-528. PMID 3802427 DOI: 10.1161/01.Res.59.5.515  0.532
1986 Vogel WM, Dennis RC, Cassidy G, Apstein CS, Valeri CR. Coronary constrictor effect of stroma-free hemoglobin solutions American Journal of Physiology-Heart and Circulatory Physiology. 251. PMID 3740293 DOI: 10.1152/Ajpheart.1986.251.2.H413  0.395
1986 Lorell BH, Wexler LF, Momomura S, Weinberg E, Apstein CS. The influence of pressure overload left ventricular hypertrophy on diastolic properties during hypoxia in isovolumically contracting rat hearts. Circulation Research. 58: 653-663. PMID 3708763 DOI: 10.1161/01.Res.58.5.653  0.505
1986 Nakamura Y, BlNG OH, Wiegner AW, Konishi T, Apstein CS, Pfeffer MA, Kawai C. Effects of hypertrophy and allylamine-induced fibrosis on mechanical properties of isolated rat heart muscles with references to the pumping function of the intact heart in the same models. Japanese Circulation Journal-English Edition. 50: 998-1006. PMID 2949093 DOI: 10.1253/Jcj.50.998  0.431
1985 Apstein CS, Dennis RC, Briggs L, Vogel WM, Frazer J, Valeri CR. Effect of erythrocyte storage and oxyhemoglobin affinity changes on cardiac function. The American Journal of Physiology. 248: H508-15. PMID 3985174 DOI: 10.1152/Ajpheart.1985.248.4.H508  0.399
1985 Vogel WM, Briggs LL, Apstein CS. Separation of inherent diastolic myocardial fiber tension and coronary vascular erectile contributions to wall stiffness of rabbit hearts damaged by ischemia, hypoxia, calcium paradox and reperfusion. Journal of Molecular and Cellular Cardiology. 17: 57-70. PMID 2580987 DOI: 10.1016/S0022-2828(85)80092-4  0.514
1984 Foster E, DeJong D, Connelly C, Apstein CS. Failure of nifedipine and reperfusion to reduce infarct size relative to region at risk as measured by NADH fluorophotography. Circulation. 70: 506-512. PMID 6744554 DOI: 10.1161/01.Cir.70.3.506  0.434
1984 Swynghedauw B, Schwartz K, Apstein CS. Decreased contractility after myocardial hypertrophy: cardiac failure or successful adaptation? American Journal of Cardiology. 54: 437-440. PMID 6235737 DOI: 10.1016/0002-9149(84)90212-1  0.464
1983 Lerman RH, Apstein CS, Kagan HM, Osmers EL, Chichester CO, Vogel WM, Connelly CM, Steffee WP. Myocardial healing and repair after experimental infarction in the rabbit. Circulation Research. 53: 378-88. PMID 6136345 DOI: 10.1161/01.Res.53.3.378  0.463
1983 Lecarpentier Y, Apstein C, Mercadier JJ, Martin JL, Wisnewsky C, Swynghedauw B, Schwartz K. Relaxation during cardiac hypertrophy after aortic insufficiency Journal of Molecular and Cellular Cardiology. 15: 16. DOI: 10.1016/0022-2828(83)90162-1  0.345
1982 Connelly C, Vogel WM, Hernandez YM, Apstein CS. Movement of necrotic wavefront after coronary artery occlusion in rabbit. American Journal of Physiology-Heart and Circulatory Physiology. 243. PMID 7137361 DOI: 10.1152/Ajpheart.1982.243.5.H682  0.455
1982 Vogel WM, Apstein CS, Briggs LL, Gaasch WH, Ahn J. Acute alterations in left ventricular diastolic chamber stiffness. Role of the "erectile" effect of coronary arterial pressure and flow in normal and damaged hearts. Circulation Research. 51: 465-78. PMID 7127681 DOI: 10.1161/01.Res.51.4.465  0.483
1981 Serizawa T, Vogel WM, Apstein CS, Grossman W. Comparison of Acute Alterations in Left Ventricular Relaxation and Diastolic Chamber Stiffness Induced by Hypoxia and Ischemia: ROLE OF MYOCARDIAL OXYGEN SUPPLY-DEMAND IMBALANCE Journal of Clinical Investigation. 68: 91-102. PMID 7251868 DOI: 10.1172/Jci110258  0.544
1980 Ogilby JD, Apstein CS. Preservation of myocardial compliance and reversal of contracture ("stone heart") during ischemic arrest by applied intermittent ventricular stretch. American Journal of Cardiology. 46: 397-404. PMID 7415984 DOI: 10.1016/0002-9149(80)90007-7  0.446
1980 Apstein CS, Dennis R, Vecchione JJ, Frazer J, Valeri CR. Improved cardiac function during coronary perfusion with low oxy-hemoglobin affinity human red blood cells American Journal of Cardiology. 45: 479. DOI: 10.1016/0002-9149(80)91024-3  0.395
1980 Briggs L, Ogilby JD, Apstein CS. Preservation of myocardial compliance during ischemic arrest by applied intermittent ventricular stretch American Journal of Cardiology. 45: 393. DOI: 10.1016/0002-9149(80)90680-3  0.51
1978 Apstein CS, Deckelbaum L, Hagopian L, Hood WB. Acute cardiac ischemia and reperfusion: contractility, relaxation, and glycolysis American Journal of Physiology-Heart and Circulatory Physiology. 235: 637-648. PMID 736151 DOI: 10.1152/Ajpheart.1978.235.6.H637  0.492
1978 Boden WE, Chang-Seng L, Apstein CS, Hood WB. Experimental myocardial infarction. XVI. The detection of inotropic contractile reserve with postextrasystolic potentiation in acutely ischemic canine myocardium American Journal of Cardiology. 41: 523-530. PMID 75688 DOI: 10.1016/0002-9149(78)90010-3  0.477
1978 Mieszala JR, Apstein CS, Yarnoz MD, Vecchione JJ, Gilman HR, Valeri CR, Berger RL. Abstract of paper to be presented at the 27th Annual Scientific Session of the American College of Cardiology Anaheim, California, March 6 to 9, 1978The effect of coronary perfusion pressure on diastolic wall stiffness in the isolated, blood-perfused dog heart American Journal of Cardiology. 41: 362. DOI: 10.1016/0002-9149(78)90221-7  0.419
1977 Apstein CS, Mueller M, Hood WB. Ventricular contracture and compliance changes with global ischemia and reperfusion, and their effect on coronary resistance in the rat. Circulation Research. 41: 206-217. PMID 872295 DOI: 10.1161/01.Res.41.2.206  0.439
1977 Apstein CS, Deckelbaum L, Mueller M, Hagopian L, Hood WB. Graded global ischemia and reperfusion. Cardiac function and lactate metabolism. Circulation. 55: 864-872. PMID 870244 DOI: 10.1161/01.Cir.55.6.864  0.503
1977 Apstein CS, Kline SA, Levin DC, Baltaxe HA, Killip T. Left ventricular performance and graft patency after coronary artery-saphenous vein bypass surgery: early and late follow-up. American Heart Journal. 93: 547-555. PMID 300555 DOI: 10.1016/S0002-8703(77)80002-1  0.356
1976 Pirzada FA, Ekong EA, Vokonas PS, Apstein CS, Hood WB. Experimental myocardial infarction. XIII. Sequential changes in left ventricular pressure length relationships in the acute phase Circulation. 53: 970-975. PMID 1269134 DOI: 10.1161/01.Cir.53.6.970  0.467
1976 Apstein CS, Bing OHL, Levine HJ. Cardiac muscle function during and after hypoxia: Effects of glucose concentration, mannitol and isoproterenol Journal of Molecular and Cellular Cardiology. 8: 627-640. PMID 972409 DOI: 10.1016/0022-2828(76)90048-1  0.34
1976 Apstein CS, Mueller M, Hood WB. Increase in post-ischemic (reperfusion) coronary vascular resistance due to cardiac contracture American Journal of Cardiology. 37: 118. DOI: 10.1016/0002-9149(76)90521-X  0.444
1975 Pirzada FA, Weiner JM, Vokonas PS, Apstein CS, Hood WB. Segmental myocardial stiffness as a determinant of dyskinesis in the acutely ischemic left ventricle American Journal of Cardiology. 35: 162. DOI: 10.1016/0002-9149(75)90754-7  0.458
1975 Deckelbaum L, Green R, Mueller M, Hood WB, Apstein CS. Acute hypoxic heart failure: Comparison of hypoxemia and ischemia American Journal of Cardiology. 35: 131. DOI: 10.1016/0002-9149(75)90628-1  0.417
1974 Weiner JM, Apstein CS, Arthur JH, Hood WB. Persistence of myocardial injury following brief periods of coronary occlusion American Journal of Cardiology. 33: 177. DOI: 10.1016/0002-9149(74)90972-2  0.398
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