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Harold L. Moses, M.D. - Publications

Vanderbilt University, Nashville, TN 
Cell Biology

67 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2017 Pickup MW, Owens P, Gorska AE, Chytil A, Ye F, Shi C, Weaver VM, Kalluri R, Moses HL, Novitskiy SV. Development of aggressive pancreatic ductal adenocarcinomas depends on granulocyte-colony stimulating factor secretion in carcinoma cells. Cancer Immunology Research. PMID 28775207 DOI: 10.1158/2326-6066.CIR-16-0311  0.48
2017 Biswas S, Guix M, Rinehart C, Dugger TC, Chytil A, Moses HL, Freeman ML, Arteaga CL. Inhibition of TGF-β with neutralizing antibodies prevents radiation-induced acceleration of metastatic cancer progression. The Journal of Clinical Investigation. 127: 1116. PMID 28248204 DOI: 10.1172/JCI93333  0.4
2017 Pickup MW, Owens P, Moses HL. TGF-β, Bone Morphogenetic Protein, and Activin Signaling and the Tumor Microenvironment. Cold Spring Harbor Perspectives in Biology. PMID 28062564 DOI: 10.1101/cshperspect.a022285  0.36
2016 Jovanović B, Pickup MW, Chytil A, Gorska AE, Johnson KC, Moses HL, Owens P. TβRIII Expression in Human Breast Cancer Stroma and the Role of Soluble TβRIII in Breast Cancer Associated Fibroblasts. Cancers. 8. PMID 27827906 DOI: 10.3390/cancers8110100  0.48
2016 Laklai H, Miroshnikova YA, Pickup MW, Collisson EA, Kim GE, Barrett AS, Hill RC, Lakins JN, Schlaepfer DD, Mouw JK, LeBleu VS, Roy N, Novitskiy SV, Johansen JS, Poli V, ... ... Moses HL, et al. Genotype tunes pancreatic ductal adenocarcinoma tissue tension to induce matricellular fibrosis and tumor progression. Nature Medicine. PMID 27089513 DOI: 10.1038/nm.4082  0.36
2015 Pickup MW, Hover LD, Guo Y, Gorska AE, Chytil A, Novitskiy SV, Moses HL, Owens P. Deletion of the BMP receptor BMPR1a impairs mammary tumor formation and metastasis. Oncotarget. PMID 26274893  0.48
2015 Shaw AK, Pickup MW, Chytil A, Aakre M, Owens P, Moses HL, Novitskiy SV. TGFβ signaling in myeloid cells regulates mammary carcinoma cell invasion through fibroblast interactions. Plos One. 10: e0117908. PMID 25629162 DOI: 10.1371/journal.pone.0117908  0.4
2015 Huh SJ, Clement K, Jee D, Merlini A, Choudhury S, Maruyama R, Yoo R, Chytil A, Boyle P, Ran FA, Moses HL, Barcellos-Hoff MH, Jackson-Grusby L, Meissner A, Polyak K. Age- and pregnancy-associated DNA methylation changes in mammary epithelial cells. Stem Cell Reports. 4: 297-311. PMID 25619437 DOI: 10.1016/j.stemcr.2014.12.009  0.4
2015 Pickup MW, Hover LD, Polikowsky ER, Chytil A, Gorska AE, Novitskiy SV, Moses HL, Owens P. BMPR2 loss in fibroblasts promotes mammary carcinoma metastasis via increased inflammation. Molecular Oncology. 9: 179-91. PMID 25205038 DOI: 10.1016/j.molonc.2014.08.004  0.48
2014 Novitskiy SV, Forrester E, Pickup MW, Gorska AE, Chytil A, Aakre M, Polosukhina D, Owens P, Yusupova DR, Zhao Z, Ye F, Shyr Y, Moses HL. Attenuated transforming growth factor beta signaling promotes metastasis in a model of HER2 mammary carcinogenesis. Breast Cancer Research : Bcr. 16: 425. PMID 25280532 DOI: 10.1186/s13058-014-0425-7  0.48
2014 Ryzhov SV, Pickup MW, Chytil A, Gorska AE, Zhang Q, Owens P, Feoktistov I, Moses HL, Novitskiy SV. Role of TGF-β signaling in generation of CD39+CD73+ myeloid cells in tumors. Journal of Immunology (Baltimore, Md. : 1950). 193: 3155-64. PMID 25127858 DOI: 10.4049/jimmunol.1400578  0.48
2014 Jovanovi? B, Beeler JS, Pickup MW, Chytil A, Gorska AE, Ashby WJ, Lehmann BD, Zijlstra A, Pietenpol JA, Moses HL. Transforming growth factor beta receptor type III is a tumor promoter in mesenchymal-stem like triple negative breast cancer. Breast Cancer Research : Bcr. 16: R69. PMID 24985072 DOI: 10.1186/bcr3684  0.48
2013 Pickup MW, Laklai H, Acerbi I, Owens P, Gorska AE, Chytil A, Aakre M, Weaver VM, Moses HL. Stromally derived lysyl oxidase promotes metastasis of transforming growth factor-β-deficient mouse mammary carcinomas. Cancer Research. 73: 5336-46. PMID 23856251 DOI: 10.1158/0008-5472.CAN-13-0012  0.48
2013 Owens P, Polikowsky H, Pickup MW, Gorska AE, Jovanovic B, Shaw AK, Novitskiy SV, Hong CC, Moses HL. Bone Morphogenetic Proteins stimulate mammary fibroblasts to promote mammary carcinoma cell invasion. Plos One. 8: e67533. PMID 23840733 DOI: 10.1371/journal.pone.0067533  0.48
2012 Matise LA, Palmer TD, Ashby WJ, Nashabi A, Chytil A, Aakre M, Pickup MW, Gorska AE, Zijlstra A, Moses HL. Lack of transforming growth factor-β signaling promotes collective cancer cell invasion through tumor-stromal crosstalk. Breast Cancer Research : Bcr. 14: R98. PMID 22748014 DOI: 10.1186/bcr3217  0.48
2012 Novitskiy SV, Pickup MW, Chytil A, Polosukhina D, Owens P, Moses HL. Deletion of TGF-β signaling in myeloid cells enhances their anti-tumorigenic properties. Journal of Leukocyte Biology. 92: 641-51. PMID 22685318 DOI: 10.1189/jlb.1211639  0.4
2012 Kurley SJ, Bierie B, Carnahan RH, Lobdell NA, Davis MA, Hofmann I, Moses HL, Muller WJ, Reynolds AB. p120-catenin is essential for terminal end bud function and mammary morphogenesis. Development (Cambridge, England). 139: 1754-64. PMID 22461563 DOI: 10.1242/dev.072769  1
2012 Owens P, Pickup MW, Novitskiy SV, Chytil A, Gorska AE, Aakre ME, West J, Moses HL. Disruption of bone morphogenetic protein receptor 2 (BMPR2) in mammary tumors promotes metastases through cell autonomous and paracrine mediators. Proceedings of the National Academy of Sciences of the United States of America. 109: 2814-9. PMID 21576484 DOI: 10.1073/pnas.1101139108  0.48
2011 Novitskiy SV, Pickup MW, Gorska AE, Owens P, Chytil A, Aakre M, Wu H, Shyr Y, Moses HL. TGF-β receptor II loss promotes mammary carcinoma progression by Th17 dependent mechanisms. Cancer Discovery. 1: 430-41. PMID 22408746 DOI: 10.1158/2159-8290.CD-11-0100  0.48
2011 Ijichi H, Chytil A, Gorska AE, Aakre ME, Bierie B, Tada M, Mohri D, Miyabayashi K, Asaoka Y, Maeda S, Ikenoue T, Tateishi K, Wright CV, Koike K, Omata M, ... Moses HL, et al. Inhibiting Cxcr2 disrupts tumor-stromal interactions and improves survival in a mouse model of pancreatic ductal adenocarcinoma. The Journal of Clinical Investigation. 121: 4106-17. PMID 21926469 DOI: 10.1172/JCI42754  1
2011 Fang WB, Jokar I, Chytil A, Moses HL, Abel T, Cheng N. Loss of one Tgfbr2 allele in fibroblasts promotes metastasis in MMTV: polyoma middle T transgenic and transplant mouse models of mammary tumor progression. Clinical & Experimental Metastasis. 28: 351-66. PMID 21374085 DOI: 10.1007/s10585-011-9373-0  0.4
2010 Xu BJ, Yan W, Jovanovic B, Shaw AK, An QA, Eng J, Chytil A, Link AJ, Moses HL. Microdialysis combined with proteomics for protein identification in breast tumor microenvironment in vivo. Cancer Microenvironment : Official Journal of the International Cancer Microenvironment Society. 4: 61-71. PMID 21505562 DOI: 10.1007/s12307-010-0046-3  0.4
2010 Yan HH, Pickup M, Pang Y, Gorska AE, Li Z, Chytil A, Geng Y, Gray JW, Moses HL, Yang L. Gr-1+CD11b+ myeloid cells tip the balance of immune protection to tumor promotion in the premetastatic lung. Cancer Research. 70: 6139-49. PMID 20631080 DOI: 10.1158/0008-5472.CAN-10-0706  0.48
2010 Bierie B, Moses HL. Transforming growth factor beta (TGF-beta) and inflammation in cancer. Cytokine & Growth Factor Reviews. 21: 49-59. PMID 20018551 DOI: 10.1016/j.cytogfr.2009.11.008  1
2009 Matise LA, Pickup MW, Moses HL. TGF-beta helps cells fly solo. Nature Cell Biology. 11: 1281-4. PMID 19838176 DOI: 10.1038/ncb1109-1281  0.36
2009 Bierie B, Moses HL. Gain or loss of TGFbeta signaling in mammary carcinoma cells can promote metastasis. Cell Cycle (Georgetown, Tex.). 8: 3319-27. PMID 19806012 DOI: 10.4161/cc.8.20.9727  1
2009 Bierie B, Chung CH, Parker JS, Stover DG, Cheng N, Chytil A, Aakre M, Shyr Y, Moses HL. Abrogation of TGF-beta signaling enhances chemokine production and correlates with prognosis in human breast cancer. The Journal of Clinical Investigation. 119: 1571-82. PMID 19451693 DOI: 10.1172/JCI37480  1
2009 Abel TW, Clark C, Bierie B, Chytil A, Aakre M, Gorska A, Moses HL. GFAP-Cre-mediated activation of oncogenic K-ras results in expansion of the subventricular zone and infiltrating glioma. Molecular Cancer Research : McR. 7: 645-53. PMID 19435821 DOI: 10.1158/1541-7786.MCR-08-0477  1
2009 Bierie B, Gorska AE, Stover DG, Moses HL. TGF-beta promotes cell death and suppresses lactation during the second stage of mammary involution. Journal of Cellular Physiology. 219: 57-68. PMID 19086032 DOI: 10.1002/jcp.21646  1
2008 Cheng N, Chytil A, Shyr Y, Joly A, Moses HL. Transforming growth factor-beta signaling-deficient fibroblasts enhance hepatocyte growth factor signaling in mammary carcinoma cells to promote scattering and invasion. Molecular Cancer Research : McR. 6: 1521-33. PMID 18922968 DOI: 10.1158/1541-7786.MCR-07-2203  0.4
2008 Brown KA, Ham AJ, Clark CN, Meller N, Law BK, Chytil A, Cheng N, Pietenpol JA, Moses HL. Identification of novel Smad2 and Smad3 associated proteins in response to TGF-beta1. Journal of Cellular Biochemistry. 105: 596-611. PMID 18729074 DOI: 10.1002/jcb.21860  0.72
2008 Bierie B, Stover DG, Abel TW, Chytil A, Gorska AE, Aakre M, Forrester E, Yang L, Wagner KU, Moses HL. Transforming growth factor-beta regulates mammary carcinoma cell survival and interaction with the adjacent microenvironment. Cancer Research. 68: 1809-19. PMID 18339861 DOI: 10.1158/0008-5472.CAN-07-5597  1
2008 Yang L, Huang J, Ren X, Gorska AE, Chytil A, Aakre M, Carbone DP, Matrisian LM, Richmond A, Lin PC, Moses HL. Abrogation of TGF beta signaling in mammary carcinomas recruits Gr-1+CD11b+ myeloid cells that promote metastasis. Cancer Cell. 13: 23-35. PMID 18167337 DOI: 10.1016/j.ccr.2007.12.004  0.48
2007 Spagnoli A, O'Rear L, Chandler RL, Granero-Molto F, Mortlock DP, Gorska AE, Weis JA, Longobardi L, Chytil A, Shimer K, Moses HL. TGF-beta signaling is essential for joint morphogenesis. The Journal of Cell Biology. 177: 1105-17. PMID 17576802 DOI: 10.1083/jcb.200611031  0.48
2007 Cheng N, Chytil A, Shyr Y, Joly A, Moses HL. Enhanced hepatocyte growth factor signaling by type II transforming growth factor-beta receptor knockout fibroblasts promotes mammary tumorigenesis. Cancer Research. 67: 4869-77. PMID 17495323 DOI: 10.1158/0008-5472.CAN-06-3381  0.4
2007 Stover DG, Bierie B, Moses HL. A delicate balance: TGF-beta and the tumor microenvironment. Journal of Cellular Biochemistry. 101: 851-61. PMID 17486574 DOI: 10.1002/jcb.21149  1
2007 Biswas S, Guix M, Rinehart C, Dugger TC, Chytil A, Moses HL, Freeman ML, Arteaga CL. Inhibition of TGF-beta with neutralizing antibodies prevents radiation-induced acceleration of metastatic cancer progression. The Journal of Clinical Investigation. 117: 1305-13. PMID 17415413 DOI: 10.1172/JCI30740  0.4
2007 Labbé E, Lock L, Letamendia A, Gorska AE, Gryfe R, Gallinger S, Moses HL, Attisano L. Transcriptional cooperation between the transforming growth factor-beta and Wnt pathways in mammary and intestinal tumorigenesis. Cancer Research. 67: 75-84. PMID 17210685 DOI: 10.1158/0008-5472.CAN-06-2559  0.48
2006 Ijichi H, Chytil A, Gorska AE, Aakre ME, Fujitani Y, Fujitani S, Wright CV, Moses HL. Aggressive pancreatic ductal adenocarcinoma in mice caused by pancreas-specific blockade of transforming growth factor-beta signaling in cooperation with active Kras expression. Genes & Development. 20: 3147-60. PMID 17114585 DOI: 10.1101/gad.1475506  0.48
2006 Muñoz NM, Upton M, Rojas A, Washington MK, Lin L, Chytil A, Sozmen EG, Madison BB, Pozzi A, Moon RT, Moses HL, Grady WM. Transforming growth factor beta receptor type II inactivation induces the malignant transformation of intestinal neoplasms initiated by Apc mutation. Cancer Research. 66: 9837-44. PMID 17047044 DOI: 10.1158/0008-5472.CAN-06-0890  0.4
2006 Bierie B, Moses HL. Tumour microenvironment: TGFbeta: the molecular Jekyll and Hyde of cancer. Nature Reviews. Cancer. 6: 506-20. PMID 16794634 DOI: 10.1038/nrc1926  1
2006 Halder SK, Anumanthan G, Maddula R, Mann J, Chytil A, Gonzalez AL, Washington MK, Moses HL, Beauchamp RD, Datta PK. Oncogenic function of a novel WD-domain protein, STRAP, in human carcinogenesis. Cancer Research. 66: 6156-66. PMID 16778189 DOI: 10.1158/0008-5472.CAN-05-3261  0.4
2006 Longobardi L, O'Rear L, Aakula S, Johnstone B, Shimer K, Chytil A, Horton WA, Moses HL, Spagnoli A. Effect of IGF-I in the chondrogenesis of bone marrow mesenchymal stem cells in the presence or absence of TGF-beta signaling. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. 21: 626-36. PMID 16598383 DOI: 10.1359/jbmr.051213  0.4
2006 Bierie B, Moses HL. TGF-beta and cancer. Cytokine & Growth Factor Reviews. 17: 29-40. PMID 16289860 DOI: 10.1016/j.cytogfr.2005.09.006  1
2005 Bierie B, Moses HL. Under pressure: stromal fibroblasts change their ways. Cell. 123: 985-7. PMID 16360028 DOI: 10.1016/j.cell.2005.11.029  1
2005 Xie L, Xu BJ, Gorska AE, Shyr Y, Schwartz SA, Cheng N, Levy S, Bierie B, Caprioli RM, Moses HL. Genomic and proteomic analysis of mammary tumors arising in transgenic mice. Journal of Proteome Research. 4: 2088-98. PMID 16335954 DOI: 10.1021/pr050214l  1
2005 Cheng N, Bhowmick NA, Chytil A, Gorksa AE, Brown KA, Muraoka R, Arteaga CL, Neilson EG, Hayward SW, Moses HL. Loss of TGF-beta type II receptor in fibroblasts promotes mammary carcinoma growth and invasion through upregulation of TGF-alpha-, MSP- and HGF-mediated signaling networks. Oncogene. 24: 5053-68. PMID 15856015 DOI: 10.1038/sj.onc.1208685  0.4
2005 Means AL, Chytil A, Moses HL, Coffey RJ, Wright CV, Taketo MM, Grady WM. Keratin 19 gene drives Cre recombinase expression throughout the early postimplantation mouse embryo. Genesis (New York, N.Y. : 2000). 42: 23-7. PMID 15828001 DOI: 10.1002/gene.20119  0.4
2005 Forrester E, Chytil A, Bierie B, Aakre M, Gorska AE, Sharif-Afshar AR, Muller WJ, Moses HL. Effect of conditional knockout of the type II TGF-beta receptor gene in mammary epithelia on mammary gland development and polyomavirus middle T antigen induced tumor formation and metastasis. Cancer Research. 65: 2296-302. PMID 15781643 DOI: 10.1158/0008-5472.CAN-04-3272  1
2005 Romero-Gallo J, Sozmen EG, Chytil A, Russell WE, Whitehead R, Parks WT, Holdren MS, Her MF, Gautam S, Magnuson M, Moses HL, Grady WM. Inactivation of TGF-beta signaling in hepatocytes results in an increased proliferative response after partial hepatectomy. Oncogene. 24: 3028-41. PMID 15735717 DOI: 10.1038/sj.onc.1208475  0.4
2004 Xie L, Law BK, Chytil AM, Brown KA, Aakre ME, Moses HL. Activation of the Erk pathway is required for TGF-beta1-induced EMT in vitro. Neoplasia (New York, N.Y.). 6: 603-10. PMID 15548370 DOI: 10.1593/neo.04241  0.72
2004 Baffi MO, Slattery E, Sohn P, Moses HL, Chytil A, Serra R. Conditional deletion of the TGF-beta type II receptor in Col2a expressing cells results in defects in the axial skeleton without alterations in chondrocyte differentiation or embryonic development of long bones. Developmental Biology. 276: 124-42. PMID 15531369 DOI: 10.1016/j.ydbio.2004.08.027  0.4
2004 Biswas S, Chytil A, Washington K, Romero-Gallo J, Gorska AE, Wirth PS, Gautam S, Moses HL, Grady WM. Transforming growth factor beta receptor type II inactivation promotes the establishment and progression of colon cancer. Cancer Research. 64: 4687-92. PMID 15256431 DOI: 10.1158/0008-5472.CAN-03-3255  0.48
2004 Brown KA, Aakre ME, Gorska AE, Price JO, Eltom SE, Pietenpol JA, Moses HL. Induction by transforming growth factor-beta1 of epithelial to mesenchymal transition is a rare event in vitro. Breast Cancer Research : Bcr. 6: R215-31. PMID 15084245 DOI: 10.1186/bcr778  0.48
2004 Bhowmick NA, Chytil A, Plieth D, Gorska AE, Dumont N, Shappell S, Washington MK, Neilson EG, Moses HL. TGF-beta signaling in fibroblasts modulates the oncogenic potential of adjacent epithelia. Science (New York, N.Y.). 303: 848-51. PMID 14764882 DOI: 10.1126/science.1090922  0.48
2003 Bhowmick NA, Ghiassi M, Aakre M, Brown K, Singh V, Moses HL. TGF-beta-induced RhoA and p160ROCK activation is involved in the inhibition of Cdc25A with resultant cell-cycle arrest. Proceedings of the National Academy of Sciences of the United States of America. 100: 15548-53. PMID 14657354 DOI: 10.1073/pnas.2536483100  0.4
2003 Muraoka RS, Koh Y, Roebuck LR, Sanders ME, Brantley-Sieders D, Gorska AE, Moses HL, Arteaga CL. Increased malignancy of Neu-induced mammary tumors overexpressing active transforming growth factor beta1. Molecular and Cellular Biology. 23: 8691-703. PMID 14612410  0.48
2003 Xie L, Law BK, Aakre ME, Edgerton M, Shyr Y, Bhowmick NA, Moses HL. Transforming growth factor beta-regulated gene expression in a mouse mammary gland epithelial cell line. Breast Cancer Research : Bcr. 5: R187-98. PMID 14580254 DOI: 10.1186/bcr640  0.72
2003 Gorska AE, Jensen RA, Shyr Y, Aakre ME, Bhowmick NA, Moses HL. Transgenic mice expressing a dominant-negative mutant type II transforming growth factor-beta receptor exhibit impaired mammary development and enhanced mammary tumor formation. The American Journal of Pathology. 163: 1539-49. PMID 14507660  0.48
2003 Ito Y, Yeo JY, Chytil A, Han J, Bringas P, Nakajima A, Shuler CF, Moses HL, Chai Y. Conditional inactivation of Tgfbr2 in cranial neural crest causes cleft palate and calvaria defects. Development (Cambridge, England). 130: 5269-80. PMID 12975342 DOI: 10.1242/dev.00708  0.4
2003 Tu WH, Thomas TZ, Masumori N, Bhowmick NA, Gorska AE, Shyr Y, Kasper S, Case T, Roberts RL, Shappell SB, Moses HL, Matusik RJ. The loss of TGF-beta signaling promotes prostate cancer metastasis. Neoplasia (New York, N.Y.). 5: 267-77. PMID 12869309  0.48
2002 Law BK, Chytil A, Dumont N, Hamilton EG, Waltner-Law ME, Aakre ME, Covington C, Moses HL. Rapamycin potentiates transforming growth factor beta-induced growth arrest in nontransformed, oncogene-transformed, and human cancer cells. Molecular and Cellular Biology. 22: 8184-98. PMID 12417722 DOI: 10.1128/MCB.22.23.8184-8198.2002  0.72
2002 Chytil A, Magnuson MA, Wright CV, Moses HL. Conditional inactivation of the TGF-beta type II receptor using Cre:Lox. Genesis (New York, N.Y. : 2000). 32: 73-5. PMID 11857781 DOI: 10.1002/gene.10046  0.4
2001 Entingh AJ, Law BK, Moses HL. Induction of the C/EBP Homologous Protein (CHOP) by Amino Acid Deprivation Requires Insulin-Like Growth Factor I, Phosphatidylinositol 3-Kinase, and Mammalian Target of Rapamycin Signaling* * This work was supported by NIH Grants CA-42572 and CA-85492. Sequencing was carried out by the DNA Sequencing Shared Resource (Grant P30-CA-68485). Data presentation was performed in part through the use of the Vanderbilt University Medical Center Cell Imaging Resource (Grants CA-68485 and DK-20593). Endocrinology. 142: 221-228. PMID 28201340 DOI: 10.1210/endo.142.1.7906  0.72
2001 Bragg AD, Moses HL, Serra R. Signaling to the epithelium is not sufficient to mediate all of the effects of transforming growth factor beta and bone morphogenetic protein 4 on murine embryonic lung development. Mechanisms of Development. 109: 13-26. PMID 11677049  0.32
2001 Entingh AJ, Law BK, Moses HL. Induction of the C/EBP homologous protein (CHOP) by amino acid deprivation requires insulin-like growth factor I, phosphatidylinositol 3-kinase, and mammalian target of rapamycin signaling. Endocrinology. 142: 221-8. PMID 11145585 DOI: 10.1210/endo.142.1.7906  0.72
2000 Law BK, Waltner-Law ME, Entingh AJ, Chytil A, Aakre ME, Nørgaard P, Moses HL. Salicylate-induced growth arrest is associated with inhibition of p70s6k and down-regulation of c-myc, cyclin D1, cyclin A, and proliferating cell nuclear antigen. The Journal of Biological Chemistry. 275: 38261-7. PMID 10993886 DOI: 10.1074/jbc.M005545200  0.72
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