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Leonard S. Jefferson - Publications

Affiliations: 
Pennsylvania State University, State College, PA, United States 
Area:
Cell Biology
Website:
https://medschool.vanderbilt.edu/mpb/person/leonard-s-jim-jefferson-phd

138 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Xu D, Shimkus KL, Lacko HA, Kutzler L, Jefferson LS, Kimball SR. Evidence for a Role for Sestrin1 in Mediating Leucine-Induced Activation of mTORC1 in Skeletal Muscle. American Journal of Physiology. Endocrinology and Metabolism. PMID 30835510 DOI: 10.1152/ajpendo.00522.2018  0.8
2019 Dierschke SK, Miller WP, Favate JS, Shah P, Imamura Kawasawa Y, Salzberg AC, Kimball SR, Jefferson LS, Dennis MD. O-GlcNAcylation alters the selection of mRNAs for translation and promotes 4E-BP1-dependent mitochondrial dysfunction in retina. The Journal of Biological Chemistry. PMID 30733333 DOI: 10.1074/jbc.RA119.007494  0.8
2018 Shimkus KL, Jefferson LS, Gordon BS, Kimball SR. Repressors of mTORC1 act to blunt the anabolic response to feeding in the soleus muscle of a cast-immobilized mouse hindlimb. Physiological Reports. 6: e13891. PMID 30338657 DOI: 10.14814/phy2.13891  0.8
2017 Black AJ, Ravi S, Jefferson LS, Kimball SR, Schilder RJ. Dietary Fat Quantity and Type Induce Transcriptome-Wide Effects on Alternative Splicing of Pre-mRNA in Rat Skeletal Muscle. The Journal of Nutrition. PMID 28768832 DOI: 10.3945/jn.117.254482  0.8
2016 Black AJ, Gordon BS, Dennis MD, Jefferson LS, Kimball SR. Regulation of protein and mRNA expression of the mTORC1 repressor REDD1 in response to leucine and serum. Biochemistry and Biophysics Reports. 8: 296-301. PMID 28367506 DOI: 10.1016/j.bbrep.2016.10.003  0.8
2016 Gordon BS, Liu C, Steiner JL, Nader GA, Jefferson LS, Kimball SR. Loss of REDD1 Augments the Rate of the Overload-Induced Increase in Muscle Mass. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. ajpregu.00159.2016. PMID 27465734 DOI: 10.1152/ajpregu.00159.2016  0.68
2016 Kimball SR, Gordon BS, Moyer JE, Dennis MD, Jefferson LS. Leucine induced dephosphorylation of Sestrin2 promotes mTORC1 activation. Cellular Signalling. PMID 27010498 DOI: 10.1016/j.cellsig.2016.03.008  0.68
2016 Miller WP, Mihailescu ML, Yang C, Barber AJ, Kimball SR, Jefferson LS, Dennis MD. The Translational Repressor 4E-BP1 Contributes to Diabetes-Induced Visual Dysfunction. Investigative Ophthalmology & Visual Science. 57: 1327-1337. PMID 26998719 DOI: 10.1167/iovs.15-18719  0.68
2015 Kimball SR, Ravi S, Gordon BS, Dennis MD, Jefferson LS. Amino Acid-Induced Activation of mTORC1 in Rat Liver Is Attenuated by Short-Term Consumption of a High-Fat Diet. The Journal of Nutrition. 145: 2496-502. PMID 26400964 DOI: 10.3945/jn.115.215491  0.68
2015 Gordon BS, Williamson DL, Lang CH, Jefferson LS, Kimball SR. Nutrient-induced stimulation of protein synthesis in mouse skeletal muscle is limited by the mTORC1 repressor REDD1. The Journal of Nutrition. 145: 708-13. PMID 25716553 DOI: 10.3945/jn.114.207621  0.68
2015 Dennis MD, Kimball SR, Fort PE, Jefferson LS. Regulated in development and DNA damage 1 is necessary for hyperglycemia-induced vascular endothelial growth factor expression in the retina of diabetic rodents. The Journal of Biological Chemistry. 290: 3865-74. PMID 25548280 DOI: 10.1074/jbc.M114.623058  0.68
2015 Kelleher AR, Pereira SL, Jefferson LS, Kimball SR. REDD2 expression in rat skeletal muscle correlates with nutrient-induced activation of mTORC1: responses to aging, immobilization, and remobilization. American Journal of Physiology. Endocrinology and Metabolism. 308: E122-9. PMID 25406262 DOI: 10.1152/ajpendo.00341.2014  0.68
2015 Wang L, Liu X, Nie J, Zhang J, Kimball SR, Zhang H, Zhang WJ, Jefferson LS, Cheng Z, Ji Q, Shi Y. ALCAT1 controls mitochondrial etiology of fatty liver diseases, linking defective mitophagy to steatosis. Hepatology (Baltimore, Md.). 61: 486-96. PMID 25203315 DOI: 10.1002/hep.27420  0.68
2014 Gordon BS, Steiner JL, Lang CH, Jefferson LS, Kimball SR. Reduced REDD1 expression contributes to activation of mTORC1 following electrically induced muscle contraction. American Journal of Physiology. Endocrinology and Metabolism. 307: E703-11. PMID 25159324 DOI: 10.1152/ajpendo.00250.2014  0.68
2014 Dennis MD, Coleman CS, Berg A, Jefferson LS, Kimball SR. REDD1 enhances protein phosphatase 2A-mediated dephosphorylation of Akt to repress mTORC1 signaling. Science Signaling. 7: ra68. PMID 25056877 DOI: 10.1126/scisignal.2005103  0.68
2014 Martin TD, Dennis MD, Gordon BS, Kimball SR, Jefferson LS. mTORC1 and JNK coordinate phosphorylation of the p70S6K1 autoinhibitory domain in skeletal muscle following functional overloading. American Journal of Physiology. Endocrinology and Metabolism. 306: E1397-405. PMID 24801387 DOI: 10.1152/ajpendo.00064.2014  0.68
2014 Kelleher AR, Gordon BS, Kimball SR, Jefferson LS. Changes in REDD1, REDD2, and atrogene mRNA expression are prevented in skeletal muscle fixed in a stretched position during hindlimb immobilization. Physiological Reports. 2: e00246. PMID 24744910 DOI: 10.1002/phy2.246  0.8
2014 Fort PE, Losiewicz MK, Pennathur S, Jefferson LS, Kimball SR, Abcouwer SF, Gardner TW. mTORC1-independent reduction of retinal protein synthesis in type 1 diabetes. Diabetes. 63: 3077-90. PMID 24740573 DOI: 10.2337/db14-0235  0.68
2014 Gordon BS, Kazi AA, Coleman CS, Dennis MD, Chau V, Jefferson LS, Kimball SR. RhoA modulates signaling through the mechanistic target of rapamycin complex 1 (mTORC1) in mammalian cells. Cellular Signalling. 26: 461-7. PMID 24316235 DOI: 10.1016/j.cellsig.2013.11.035  0.68
2013 Dennis MD, McGhee NK, Jefferson LS, Kimball SR. Regulated in DNA damage and development 1 (REDD1) promotes cell survival during serum deprivation by sustaining repression of signaling through the mechanistic target of rapamycin in complex 1 (mTORC1). Cellular Signalling. 25: 2709-16. PMID 24018049 DOI: 10.1016/j.cellsig.2013.08.038  0.68
2013 Nie J, Liu X, Lilley BN, Zhang H, Pan YA, Kimball SR, Zhang J, Zhang W, Wang L, Jefferson LS, Sanes JR, Han X, Shi Y. SAD-A kinase controls islet β-cell size and function as a mediator of mTORC1 signaling. Proceedings of the National Academy of Sciences of the United States of America. 110: 13857-62. PMID 23922392 DOI: 10.1073/pnas.1307698110  0.68
2013 Tuckow AP, Kazi AA, Kimball SR, Jefferson LS. Identification of ubiquitin-modified lysine residues and novel phosphorylation sites on eukaryotic initiation factor 2B epsilon. Biochemical and Biophysical Research Communications. 436: 41-6. PMID 23707720 DOI: 10.1016/j.bbrc.2013.05.053  0.68
2013 Dennis MD, Shenberger JS, Stanley BA, Kimball SR, Jefferson LS. Hyperglycemia mediates a shift from cap-dependent to cap-independent translation via a 4E-BP1-dependent mechanism. Diabetes. 62: 2204-14. PMID 23434932 DOI: 10.2337/db12-1453  0.68
2013 Kelleher AR, Kimball SR, Dennis MD, Schilder RJ, Jefferson LS. The mTORC1 signaling repressors REDD1/2 are rapidly induced and activation of p70S6K1 by leucine is defective in skeletal muscle of an immobilized rat hindlimb. American Journal of Physiology. Endocrinology and Metabolism. 304: E229-36. PMID 23193052 DOI: 10.1152/ajpendo.00409.2012  0.68
2013 Dennis MD, Kimball SR, Jefferson LS. Mechanistic target of rapamycin complex 1 (mTORC1)-mediated phosphorylation is governed by competition between substrates for interaction with raptor. The Journal of Biological Chemistry. 288: 10-9. PMID 23184952 DOI: 10.1074/jbc.M112.402461  0.68
2013 Cheng Y, Ren X, Zhang Y, Shan Y, Huber-Keener KJ, Zhang L, Kimball SR, Harvey H, Jefferson LS, Yang JM. Integrated regulation of autophagy and apoptosis by EEF2K controls cellular fate and modulates the efficacy of curcumin and velcade against tumor cells. Autophagy. 9: 208-19. PMID 23182879 DOI: 10.4161/auto.22801  0.68
2012 Dennis MD, Jefferson LS, Kimball SR. Role of p70S6K1-mediated phosphorylation of eIF4B and PDCD4 proteins in the regulation of protein synthesis. The Journal of Biological Chemistry. 287: 42890-9. PMID 23105104 DOI: 10.1074/jbc.M112.404822  0.68
2012 Kimball SR, Jefferson LS. Induction of REDD1 gene expression in the liver in response to endoplasmic reticulum stress is mediated through a PERK, eIF2α phosphorylation, ATF4-dependent cascade. Biochemical and Biophysical Research Communications. 427: 485-9. PMID 23000413 DOI: 10.1016/j.bbrc.2012.09.074  0.68
2012 Schilder RJ, Kimball SR, Jefferson LS. Cell-autonomous regulation of fast troponin T pre-mRNA alternative splicing in response to mechanical stretch. American Journal of Physiology. Cell Physiology. 303: C298-307. PMID 22592404 DOI: 10.1152/ajpcell.00400.2011  0.68
2011 Kumari R, Willing LB, Jefferson LS, Simpson IA, Kimball SR. REDD1 (regulated in development and DNA damage response 1) expression in skeletal muscle as a surrogate biomarker of the efficiency of glucocorticoid receptor blockade. Biochemical and Biophysical Research Communications. 412: 644-7. PMID 21856283 DOI: 10.1016/j.bbrc.2011.08.017  0.68
2011 Dennis MD, Schrufer TL, Bronson SK, Kimball SR, Jefferson LS. Hyperglycemia-induced O-GlcNAcylation and truncation of 4E-BP1 protein in liver of a mouse model of type 1 diabetes. The Journal of Biological Chemistry. 286: 34286-97. PMID 21840999 DOI: 10.1074/jbc.M111.259457  0.68
2011 Schilder RJ, Kimball SR, Marden JH, Jefferson LS. Body weight-dependent troponin T alternative splicing is evolutionarily conserved from insects to mammals and is partially impaired in skeletal muscle of obese rats. The Journal of Experimental Biology. 214: 1523-32. PMID 21490260 DOI: 10.1242/jeb.051763  0.68
2011 Winter JN, Jefferson LS, Kimball SR. ERK and Akt signaling pathways function through parallel mechanisms to promote mTORC1 signaling. American Journal of Physiology. Cell Physiology. 300: C1172-80. PMID 21289294 DOI: 10.1152/ajpcell.00504.2010  0.68
2011 Dennis MD, Baum JI, Kimball SR, Jefferson LS. Mechanisms involved in the coordinate regulation of mTORC1 by insulin and amino acids. The Journal of Biological Chemistry. 286: 8287-96. PMID 21239491 DOI: 10.1074/jbc.M110.209171  0.68
2011 Tuckow AP, Jefferson SJ, Kimball SR, Jefferson LS. Simvastatin represses protein synthesis in the muscle-derived C₂C₁₂ cell line with a concomitant reduction in eukaryotic initiation factor 2B expression. American Journal of Physiology. Endocrinology and Metabolism. 300: E564-70. PMID 21224482 DOI: 10.1152/ajpendo.00383.2010  0.68
2011 Fox TE, Bewley MC, Unrath KA, Pedersen MM, Anderson RE, Jung DY, Jefferson LS, Kim JK, Bronson SK, Flanagan JM, Kester M. Circulating sphingolipid biomarkers in models of type 1 diabetes. Journal of Lipid Research. 52: 509-17. PMID 21068007 DOI: 10.1194/jlr.M010595  0.68
2010 Li J, Romestaing C, Han X, Li Y, Hao X, Wu Y, Sun C, Liu X, Jefferson LS, Xiong J, Lanoue KF, Chang Z, Lynch CJ, Wang H, Shi Y. Cardiolipin remodeling by ALCAT1 links oxidative stress and mitochondrial dysfunction to obesity. Cell Metabolism. 12: 154-65. PMID 20674860 DOI: 10.1016/j.cmet.2010.07.003  0.68
2010 Kimball SR, Jefferson LS. Control of translation initiation through integration of signals generated by hormones, nutrients, and exercise. The Journal of Biological Chemistry. 285: 29027-32. PMID 20576612 DOI: 10.1074/jbc.R110.137208  0.68
2010 Schrufer TL, Antonetti DA, Sonenberg N, Kimball SR, Gardner TW, Jefferson LS. Ablation of 4E-BP1/2 prevents hyperglycemia-mediated induction of VEGF expression in the rodent retina and in Muller cells in culture. Diabetes. 59: 2107-16. PMID 20547975 DOI: 10.2337/db10-0148  0.68
2010 Tuckow AP, Vary TC, Kimball SR, Jefferson LS. Ectopic expression of eIF2Bepsilon in rat skeletal muscle rescues the sepsis-induced reduction in guanine nucleotide exchange activity and protein synthesis. American Journal of Physiology. Endocrinology and Metabolism. 299: E241-8. PMID 20484009 DOI: 10.1152/ajpendo.00151.2010  0.8
2010 Winter JN, Fox TE, Kester M, Jefferson LS, Kimball SR. Phosphatidic acid mediates activation of mTORC1 through the ERK signaling pathway. American Journal of Physiology. Cell Physiology. 299: C335-44. PMID 20427710 DOI: 10.1152/ajpcell.00039.2010  0.68
2010 Harding SV, Adegoke OA, Fraser KG, Marliss EB, Chevalier S, Kimball SR, Jefferson LS, Wykes LJ. Maintaining adequate nutrition, not probiotic administration, prevents growth stunting and maintains skeletal muscle protein synthesis rates in a piglet model of colitis. Pediatric Research. 67: 268-73. PMID 19952868 DOI: 10.1203/PDR.0b013e3181cb8e49  0.8
2009 Freeman WM, Bixler GV, Brucklacher RM, Walsh E, Kimball SR, Jefferson LS, Bronson SK. Transcriptomic comparison of the retina in two mouse models of diabetes. Journal of Ocular Biology, Diseases, and Informatics. 2: 202-213. PMID 20157355 DOI: 10.1007/s12177-009-9045-3  0.8
2009 Baum JI, Kimball SR, Jefferson LS. Glucagon acts in a dominant manner to repress insulin-induced mammalian target of rapamycin complex 1 signaling in perfused rat liver. American Journal of Physiology. Endocrinology and Metabolism. 297: E410-5. PMID 19509187 DOI: 10.1152/ajpendo.00042.2009  0.68
2009 Dang Do AN, Kimball SR, Cavener DR, Jefferson LS. eIF2alpha kinases GCN2 and PERK modulate transcription and translation of distinct sets of mRNAs in mouse liver. Physiological Genomics. 38: 328-41. PMID 19509078 DOI: 10.1152/physiolgenomics.90396.2008  0.68
2009 McGhee NK, Jefferson LS, Kimball SR. Elevated corticosterone associated with food deprivation upregulates expression in rat skeletal muscle of the mTORC1 repressor, REDD1. The Journal of Nutrition. 139: 828-34. PMID 19297425 DOI: 10.3945/jn.108.099846  0.68
2009 Zhang L, Kimball SR, Jefferson LS, Shenberger JS. Hydrogen peroxide impairs insulin-stimulated assembly of mTORC1. Free Radical Biology & Medicine. 46: 1500-9. PMID 19281842 DOI: 10.1016/j.freeradbiomed.2009.03.001  0.8
2009 Whitney ML, Jefferson LS, Kimball SR. ATF4 is necessary and sufficient for ER stress-induced upregulation of REDD1 expression. Biochemical and Biophysical Research Communications. 379: 451-5. PMID 19114033 DOI: 10.1016/j.bbrc.2008.12.079  0.68
2009 Adegoke OA, Chevalier S, Morais JA, Gougeon R, Kimball SR, Jefferson LS, Wing SS, Marliss EB. Fed-state clamp stimulates cellular mechanisms of muscle protein anabolism and modulates glucose disposal in normal men. American Journal of Physiology. Endocrinology and Metabolism. 296: E105-13. PMID 18957614 DOI: 10.1152/ajpendo.90752.2008  0.8
2008 Gallagher JW, Kubica N, Kimball SR, Jefferson LS. Reduced eukaryotic initiation factor 2Bepsilon-subunit expression suppresses the transformed phenotype of cells overexpressing the protein. Cancer Research. 68: 8752-60. PMID 18974117 DOI: 10.1158/0008-5472.CAN-08-1042  0.8
2008 Dardevet D, Kimball SR, Jefferson LS, Cherrington AD, Rémond D, DiCostanzo CA, Moore MC. Portal infusion of amino acids is more efficient than peripheral infusion in stimulating liver protein synthesis at the same hepatic amino acid load in dogs. The American Journal of Clinical Nutrition. 88: 986-96. PMID 18842785  0.8
2008 Reiter AK, Bolster DR, Crozier SJ, Kimball SR, Jefferson LS. AMPK represses TOP mRNA translation but not global protein synthesis in liver. Biochemical and Biophysical Research Communications. 374: 345-50. PMID 18638456 DOI: 10.1016/j.bbrc.2008.07.025  0.68
2008 Orellana RA, Suryawan A, Kimball SR, Wu G, Nguyen HV, Jefferson LS, Davis TA. Insulin signaling in skeletal muscle and liver of neonatal pigs during endotoxemia. Pediatric Research. 64: 505-10. PMID 18596577 DOI: 10.1203/PDR.0b013e318183fd4c  0.8
2008 Kubica N, Crispino JL, Gallagher JW, Kimball SR, Jefferson LS. Activation of the mammalian target of rapamycin complex 1 is both necessary and sufficient to stimulate eukaryotic initiation factor 2Bvarepsilon mRNA translation and protein synthesis. The International Journal of Biochemistry & Cell Biology. 40: 2522-33. PMID 18556237 DOI: 10.1016/j.biocel.2008.04.010  0.8
2008 Kimball SR, Abbas A, Jefferson LS. Melatonin represses oxidative stress-induced activation of the MAP kinase and mTOR signaling pathways in H4IIE hepatoma cells through inhibition of Ras. Journal of Pineal Research. 44: 379-86. PMID 18410586 DOI: 10.1111/j.1600-079X.2007.00539.x  0.68
2008 Kimball SR, Do AN, Kutzler L, Cavener DR, Jefferson LS. Rapid turnover of the mTOR complex 1 (mTORC1) repressor REDD1 and activation of mTORC1 signaling following inhibition of protein synthesis. The Journal of Biological Chemistry. 283: 3465-75. PMID 18070882 DOI: 10.1074/jbc.M706643200  0.68
2007 Manni A, Rager T, Kimball SR, Jefferson LS, Washington S, Hu X, Verderame MF. Effects of alpha-difluoromethylornithine on thrombospondin-1 production by human breast cancer cells. International Journal of Oncology. 31: 1187-91. PMID 17912446  0.8
2007 Shaheen HH, Horetsky RL, Kimball SR, Murthi A, Jefferson LS, Hopper AK. Retrograde nuclear accumulation of cytoplasmic tRNA in rat hepatoma cells in response to amino acid deprivation. Proceedings of the National Academy of Sciences of the United States of America. 104: 8845-50. PMID 17502605 DOI: 10.1073/pnas.0700765104  0.68
2007 Vary TC, Anthony JC, Jefferson LS, Kimball SR, Lynch CJ. Rapamycin blunts nutrient stimulation of eIF4G, but not PKCepsilon phosphorylation, in skeletal muscle. American Journal of Physiology. Endocrinology and Metabolism. 293: E188-96. PMID 17389711 DOI: 10.1152/ajpendo.00037.2007  0.68
2007 Krawiec BJ, Nystrom GJ, Frost RA, Jefferson LS, Lang CH. AMP-activated protein kinase agonists increase mRNA content of the muscle-specific ubiquitin ligases MAFbx and MuRF1 in C2C12 cells. American Journal of Physiology. Endocrinology and Metabolism. 292: E1555-67. PMID 17264220 DOI: 10.1152/ajpendo.00622.2006  0.4
2007 Orellana RA, Kimball SR, Suryawan A, Escobar J, Nguyen HV, Jefferson LS, Davis TA. Insulin stimulates muscle protein synthesis in neonates during endotoxemia despite repression of translation initiation. American Journal of Physiology. Endocrinology and Metabolism. 292: E629-36. PMID 17047163 DOI: 10.1152/ajpendo.00214.2006  0.8
2007 Ramesh G, Kimball SR, Jefferson LS, Reeves WB. Endotoxin and cisplatin synergistically stimulate TNF-alpha production by renal epithelial cells. American Journal of Physiology. Renal Physiology. 292: F812-9. PMID 17032936 DOI: 10.1152/ajprenal.00277.2006  0.8
2007 Frost RA, Nystrom GJ, Jefferson LS, Lang CH. Hormone, cytokine, and nutritional regulation of sepsis-induced increases in atrogin-1 and MuRF1 in skeletal muscle. American Journal of Physiology. Endocrinology and Metabolism. 292: E501-12. PMID 17003238 DOI: 10.1152/ajpendo.00359.2006  0.4
2006 Wang H, Kubica N, Ellisen LW, Jefferson LS, Kimball SR. Dexamethasone represses signaling through the mammalian target of rapamycin in muscle cells by enhancing expression of REDD1. The Journal of Biological Chemistry. 281: 39128-34. PMID 17074751 DOI: 10.1074/jbc.M610023200  0.8
2006 Antonetti DA, Barber AJ, Bronson SK, Freeman WM, Gardner TW, Jefferson LS, Kester M, Kimball SR, Krady JK, LaNoue KF, Norbury CC, Quinn PG, Sandirasegarane L, Simpson IA. Diabetic retinopathy: seeing beyond glucose-induced microvascular disease. Diabetes. 55: 2401-11. PMID 16936187 DOI: 10.2337/db05-1635  0.68
2006 Kubica N, Jefferson LS, Kimball SR. Eukaryotic initiation factor 2B and its role in alterations in mRNA translation that occur under a number of pathophysiological and physiological conditions. Progress in Nucleic Acid Research and Molecular Biology. 81: 271-96. PMID 16891174 DOI: 10.1016/S0079-6603(06)81007-X  0.68
2006 Williamson DL, Bolster DR, Kimball SR, Jefferson LS. Time course changes in signaling pathways and protein synthesis in C2C12 myotubes following AMPK activation by AICAR. American Journal of Physiology. Endocrinology and Metabolism. 291: E80-9. PMID 16760336 DOI: 10.1152/ajpendo.00566.2005  0.68
2006 Crozier SJ, Zhang X, Wang J, Cheung J, Kimball SR, Jefferson LS. Activation of signaling pathways and regulatory mechanisms of mRNA translation following myocardial ischemia-reperfusion. Journal of Applied Physiology (Bethesda, Md. : 1985). 101: 576-82. PMID 16690784 DOI: 10.1152/japplphysiol.01122.2005  0.8
2006 Williamson DL, Kubica N, Kimball SR, Jefferson LS. Exercise-induced alterations in extracellular signal-regulated kinase 1/2 and mammalian target of rapamycin (mTOR) signalling to regulatory mechanisms of mRNA translation in mouse muscle. The Journal of Physiology. 573: 497-510. PMID 16543272 DOI: 10.1113/jphysiol.2005.103481  0.68
2006 Kimball SR, Jefferson LS. New functions for amino acids: effects on gene transcription and translation. The American Journal of Clinical Nutrition. 83: 500S-507S. PMID 16470021  0.68
2006 Palmer LK, Rannels SL, Kimball SR, Jefferson LS, Keil RL. Inhibition of mammalian translation initiation by volatile anesthetics. American Journal of Physiology. Endocrinology and Metabolism. 290: E1267-75. PMID 16434554 DOI: 10.1152/ajpendo.00463.2005  0.8
2006 Kimball SR, Jefferson LS. Signaling pathways and molecular mechanisms through which branched-chain amino acids mediate translational control of protein synthesis. The Journal of Nutrition. 136: 227S-31S. PMID 16365087  0.68
2006 Kline CL, Schrufer TL, Jefferson LS, Kimball SR. Glucosamine-induced phosphorylation of the alpha-subunit of eukaryotic initiation factor 2 is mediated by the protein kinase R-like endoplasmic-reticulum associated kinase. The International Journal of Biochemistry & Cell Biology. 38: 1004-14. PMID 16324875 DOI: 10.1016/j.biocel.2005.10.015  0.8
2006 Escobar J, Frank JW, Suryawan A, Nguyen HV, Kimball SR, Jefferson LS, Davis TA. Regulation of cardiac and skeletal muscle protein synthesis by individual branched-chain amino acids in neonatal pigs. American Journal of Physiology. Endocrinology and Metabolism. 290: E612-21. PMID 16278252 DOI: 10.1152/ajpendo.00402.2005  0.8
2006 Frank JW, Escobar J, Suryawan A, Nguyen HV, Kimball SR, Jefferson LS, Davis TA. Dietary protein and lactose increase translation initiation factor activation and tissue protein synthesis in neonatal pigs. American Journal of Physiology. Endocrinology and Metabolism. 290: E225-33. PMID 16144813 DOI: 10.1152/ajpendo.00351.2005  0.8
2005 Krawiec BJ, Frost RA, Vary TC, Jefferson LS, Lang CH. Hindlimb casting decreases muscle mass in part by proteasome-dependent proteolysis but independent of protein synthesis. American Journal of Physiology. Endocrinology and Metabolism. 289: E969-80. PMID 16046454 DOI: 10.1152/ajpendo.00126.2005  0.44
2005 Frank JW, Escobar J, Suryawan A, Kimball SR, Nguyen HV, Jefferson LS, Davis TA. Protein synthesis and translation initiation factor activation in neonatal pigs fed increasing levels of dietary protein. The Journal of Nutrition. 135: 1374-81. PMID 15930440  0.8
2005 Crozier SJ, Vary TC, Kimball SR, Jefferson LS. Cellular energy status modulates translational control mechanisms in ischemic-reperfused rat hearts. American Journal of Physiology. Heart and Circulatory Physiology. 289: H1242-50. PMID 15894572 DOI: 10.1152/ajpheart.00859.2004  0.8
2005 Crozier SJ, Kimball SR, Emmert SW, Anthony JC, Jefferson LS. Oral leucine administration stimulates protein synthesis in rat skeletal muscle. The Journal of Nutrition. 135: 376-82. PMID 15735066  0.68
2005 Reiter AK, Crozier SJ, Kimball SR, Jefferson LS. Meal feeding alters translational control of gene expression in rat liver. The Journal of Nutrition. 135: 367-75. PMID 15735065  0.8
2005 Williamson DL, Kimball SR, Jefferson LS. Acute treatment with TNF-alpha attenuates insulin-stimulated protein synthesis in cultures of C2C12 myotubes through a MEK1-sensitive mechanism. American Journal of Physiology. Endocrinology and Metabolism. 289: E95-104. PMID 15701678 DOI: 10.1152/ajpendo.00397.2004  0.68
2005 Kimball SR, Jefferson LS. Role of amino acids in the translational control of protein synthesis in mammals. Seminars in Cell & Developmental Biology. 16: 21-7. PMID 15659336 DOI: 10.1016/j.semcdb.2004.11.009  0.68
2005 Escobar J, Frank JW, Suryawan A, Nguyen HV, Kimball SR, Jefferson LS, Davis TA. Physiological rise in plasma leucine stimulates muscle protein synthesis in neonatal pigs by enhancing translation initiation factor activation. American Journal of Physiology. Endocrinology and Metabolism. 288: E914-21. PMID 15644455 DOI: 10.1152/ajpendo.00510.2004  0.8
2005 Reiter AK, Bolster DR, Crozier SJ, Kimball SR, Jefferson LS. Repression of protein synthesis and mTOR signaling in rat liver mediated by the AMPK activator aminoimidazole carboxamide ribonucleoside. American Journal of Physiology. Endocrinology and Metabolism. 288: E980-8. PMID 15613684 DOI: 10.1152/ajpendo.00333.2004  0.68
2005 Kubica N, Bolster DR, Farrell PA, Kimball SR, Jefferson LS. Resistance exercise increases muscle protein synthesis and translation of eukaryotic initiation factor 2Bepsilon mRNA in a mammalian target of rapamycin-dependent manner. The Journal of Biological Chemistry. 280: 7570-80. PMID 15591312 DOI: 10.1074/jbc.M413732200  0.68
2004 Kimball SR, Jefferson LS. Amino acids as regulators of gene expression. Nutrition & Metabolism. 1: 3. PMID 15507151 DOI: 10.1186/1743-7075-1-3  0.68
2004 Kimball SR, Siegfried BA, Jefferson LS. Glucagon represses signaling through the mammalian target of rapamycin in rat liver by activating AMP-activated protein kinase. The Journal of Biological Chemistry. 279: 54103-9. PMID 15494402 DOI: 10.1074/jbc.M410755200  0.68
2004 Goggin MM, Nelsen CJ, Kimball SR, Jefferson LS, Morley SJ, Albrecht JH. Rapamycin-sensitive induction of eukaryotic initiation factor 4F in regenerating mouse liver. Hepatology (Baltimore, Md.). 40: 537-44. PMID 15349891 DOI: 10.1002/hep.20338  0.68
2004 Reiter AK, Anthony TG, Anthony JC, Jefferson LS, Kimball SR. The mTOR signaling pathway mediates control of ribosomal protein mRNA translation in rat liver. The International Journal of Biochemistry & Cell Biology. 36: 2169-79. PMID 15313464 DOI: 10.1016/j.biocel.2004.04.004  0.68
2004 Bolster DR, Jefferson LS, Kimball SR. Regulation of protein synthesis associated with skeletal muscle hypertrophy by insulin-, amino acid- and exercise-induced signalling. The Proceedings of the Nutrition Society. 63: 351-6. PMID 15294054 DOI: 10.1079/PNS2004355  0.68
2004 Bolster DR, Vary TC, Kimball SR, Jefferson LS. Leucine regulates translation initiation in rat skeletal muscle via enhanced eIF4G phosphorylation. The Journal of Nutrition. 134: 1704-10. PMID 15226457  0.68
2004 Kimball SR, O'Malley JP, Anthony JC, Crozier SJ, Jefferson LS. Assessment of biomarkers of protein anabolism in skeletal muscle during the life span of the rat: sarcopenia despite elevated protein synthesis. American Journal of Physiology. Endocrinology and Metabolism. 287: E772-80. PMID 15187001 DOI: 10.1152/ajpendo.00535.2003  0.68
2004 Kimball SR, Jefferson LS. Molecular mechanisms through which amino acids mediate signaling through the mammalian target of rapamycin. Current Opinion in Clinical Nutrition and Metabolic Care. 7: 39-44. PMID 15090902 DOI: 10.1097/00075197-200401000-00008  0.68
2004 O'Connor PM, Kimball SR, Suryawan A, Bush JA, Nguyen HV, Jefferson LS, Davis TA. Regulation of neonatal liver protein synthesis by insulin and amino acids in pigs. American Journal of Physiology. Endocrinology and Metabolism. 286: E994-E1003. PMID 14761876 DOI: 10.1152/ajpendo.00391.2003  0.68
2004 Kimball SR, Horetsky RL, Jefferson LS. A microtiter plate assay for assessing the interaction of eukaryotic initiation factor eIF4E with eIF4G and eIF4E binding protein-1. Analytical Biochemistry. 325: 364-8. PMID 14751272 DOI: 10.1016/j.ab.2003.11.016  0.68
2004 Suryawan A, O'Connor PM, Kimball SR, Bush JA, Nguyen HV, Jefferson LS, Davis TA. Amino acids do not alter the insulin-induced activation of the insulin signaling pathway in neonatal pigs. The Journal of Nutrition. 134: 24-30. PMID 14704288  0.68
2004 Kimball SR, Jefferson LS. Regulation of global and specific mRNA translation by oral administration of branched-chain amino acids. Biochemical and Biophysical Research Communications. 313: 423-7. PMID 14684179 DOI: 10.1016/j.bbrc.2003.07.014  0.68
2004 Orellana RA, Kimball SR, Nguyen HV, Bush JA, Suryawan A, Thivierge MC, Jefferson LS, Davis TA. Regulation of muscle protein synthesis in neonatal pigs during prolonged endotoxemia. Pediatric Research. 55: 442-9. PMID 14681494 DOI: 10.1203/01.PDR.0000110526.02282.F3  0.68
2004 Wu X, Reiter CE, Antonetti DA, Kimball SR, Jefferson LS, Gardner TW. Insulin promotes rat retinal neuronal cell survival in a p70S6K-dependent manner. The Journal of Biological Chemistry. 279: 9167-75. PMID 14660591 DOI: 10.1074/jbc.M312397200  0.68
2004 Kubica N, Kimball SR, Jefferson LS, Farrell PA. Alterations in the expression of mRNAs and proteins that code for species relevant to eIF2B activity after an acute bout of resistance exercise. Journal of Applied Physiology (Bethesda, Md. : 1985). 96: 679-87. PMID 14565967 DOI: 10.1152/japplphysiol.00962.2003  0.8
2003 Lang CH, Frost RA, Deshpande N, Kumar V, Vary TC, Jefferson LS, Kimball SR. Alcohol impairs leucine-mediated phosphorylation of 4E-BP1, S6K1, eIF4G, and mTOR in skeletal muscle. American Journal of Physiology. Endocrinology and Metabolism. 285: E1205-15. PMID 12944322 DOI: 10.1152/ajpendo.00177.2003  0.8
2003 Bolster DR, Kubica N, Crozier SJ, Williamson DL, Farrell PA, Kimball SR, Jefferson LS. Immediate response of mammalian target of rapamycin (mTOR)-mediated signalling following acute resistance exercise in rat skeletal muscle. The Journal of Physiology. 553: 213-20. PMID 12937293 DOI: 10.1113/jphysiol.2003.047019  0.68
2003 Bolster DR, Kimball SR, Jefferson LS. Translational control mechanisms modulate skeletal muscle gene expression during hypertrophy. Exercise and Sport Sciences Reviews. 31: 111-6. PMID 12882475  0.68
2003 Crozier SJ, Anthony JC, Schworer CM, Reiter AK, Anthony TG, Kimball SR, Jefferson LS. Tissue-specific regulation of protein synthesis by insulin and free fatty acids. American Journal of Physiology. Endocrinology and Metabolism. 285: E754-62. PMID 12837665 DOI: 10.1152/ajpendo.00063.2003  0.68
2003 Kimball SR, Orellana RA, O'Connor PM, Suryawan A, Bush JA, Nguyen HV, Thivierge MC, Jefferson LS, Davis TA. Endotoxin induces differential regulation of mTOR-dependent signaling in skeletal muscle and liver of neonatal pigs. American Journal of Physiology. Endocrinology and Metabolism. 285: E637-44. PMID 12773308 DOI: 10.1152/ajpendo.00340.2002  0.68
2003 Jefferson LS, Kimball SR. Amino acids as regulators of gene expression at the level of mRNA translation. The Journal of Nutrition. 133: 2046S-2051S. PMID 12771363  0.68
2003 Bush JA, Kimball SR, O'Connor PM, Suryawan A, Orellana RA, Nguyen HV, Jefferson LS, Davis TA. Translational control of protein synthesis in muscle and liver of growth hormone-treated pigs. Endocrinology. 144: 1273-83. PMID 12639910 DOI: 10.1210/en.2002-220983  0.68
2003 O'Connor PM, Kimball SR, Suryawan A, Bush JA, Nguyen HV, Jefferson LS, Davis TA. Regulation of translation initiation by insulin and amino acids in skeletal muscle of neonatal pigs. American Journal of Physiology. Endocrinology and Metabolism. 285: E40-53. PMID 12637260 DOI: 10.1152/ajpendo.00563.2002  0.68
2003 Kobayashi H, Børsheim E, Anthony TG, Traber DL, Badalamenti J, Kimball SR, Jefferson LS, Wolfe RR. Reduced amino acid availability inhibits muscle protein synthesis and decreases activity of initiation factor eIF2B. American Journal of Physiology. Endocrinology and Metabolism. 284: E488-98. PMID 12556349 DOI: 10.1152/ajpendo.00094.2002  0.8
2003 Kimball SR, Horetsky RL, Ron D, Jefferson LS, Harding HP. Mammalian stress granules represent sites of accumulation of stalled translation initiation complexes. American Journal of Physiology. Cell Physiology. 284: C273-84. PMID 12388085 DOI: 10.1152/ajpcell.00314.2002  0.8
2002 Crozier SJ, Bolster DR, Reiter AK, Kimball SR, Jefferson LS. Beta -oxidation of free fatty acids is required to maintain translational control of protein synthesis in heart. American Journal of Physiology. Endocrinology and Metabolism. 283: E1144-50. PMID 12388121 DOI: 10.1152/ajpendo.00277.2002  0.68
2002 Zhang P, McGrath BC, Reinert J, Olsen DS, Lei L, Gill S, Wek SA, Vattem KM, Wek RC, Kimball SR, Jefferson LS, Cavener DR. The GCN2 eIF2alpha kinase is required for adaptation to amino acid deprivation in mice. Molecular and Cellular Biology. 22: 6681-8. PMID 12215525 DOI: 10.1128/MCB.22.19.6681-6688.2002  0.68
2002 Kimball SR, Farrell PA, Jefferson LS. Invited Review: Role of insulin in translational control of protein synthesis in skeletal muscle by amino acids or exercise. Journal of Applied Physiology (Bethesda, Md. : 1985). 93: 1168-80. PMID 12183515 DOI: 10.1152/japplphysiol.00221.2002  0.68
2002 Lynch CJ, Patson BJ, Anthony J, Vaval A, Jefferson LS, Vary TC. Leucine is a direct-acting nutrient signal that regulates protein synthesis in adipose tissue. American Journal of Physiology. Endocrinology and Metabolism. 283: E503-13. PMID 12169444 DOI: 10.1152/ajpendo.00084.2002  0.68
2002 Shah OJ, Kimball SR, Jefferson LS. The Src-family tyrosine kinase inhibitor PP1 interferes with the activation of ribosomal protein S6 kinases. The Biochemical Journal. 366: 57-62. PMID 12014987 DOI: 10.1042/BJ20020198  0.68
2002 Bolster DR, Crozier SJ, Kimball SR, Jefferson LS. AMP-activated protein kinase suppresses protein synthesis in rat skeletal muscle through down-regulated mammalian target of rapamycin (mTOR) signaling. The Journal of Biological Chemistry. 277: 23977-80. PMID 11997383 DOI: 10.1074/jbc.C200171200  0.68
2002 Anthony JC, Lang CH, Crozier SJ, Anthony TG, MacLean DA, Kimball SR, Jefferson LS. Contribution of insulin to the translational control of protein synthesis in skeletal muscle by leucine. American Journal of Physiology. Endocrinology and Metabolism. 282: E1092-101. PMID 11934675 DOI: 10.1152/ajpendo.00208.2001  0.8
2002 Anthony JC, Reiter AK, Anthony TG, Crozier SJ, Lang CH, MacLean DA, Kimball SR, Jefferson LS. Orally administered leucine enhances protein synthesis in skeletal muscle of diabetic rats in the absence of increases in 4E-BP1 or S6K1 phosphorylation. Diabetes. 51: 928-36. PMID 11916909  0.8
2002 Kimball SR, Farrell PA, Nguyen HV, Jefferson LS, Davis TA. Developmental decline in components of signal transduction pathways regulating protein synthesis in pig muscle. American Journal of Physiology. Endocrinology and Metabolism. 282: E585-92. PMID 11832361 DOI: 10.1152/ajpendo.00269.2001  0.8
2002 Kimball SR, Jefferson LS. Control of protein synthesis by amino acid availability. Current Opinion in Clinical Nutrition and Metabolic Care. 5: 63-7. PMID 11790952  0.68
2002 Shah OJ, Iniguez-Lluhi JA, Romanelli A, Kimball SR, Jefferson LS. The activated glucocorticoid receptor modulates presumptive autoregulation of ribosomal protein S6 protein kinase, p70 S6K. The Journal of Biological Chemistry. 277: 2525-33. PMID 11705993 DOI: 10.1074/jbc.M105935200  0.8
2001 Anthony TG, Reiter AK, Anthony JC, Kimball SR, Jefferson LS. Deficiency of dietary EAA preferentially inhibits mRNA translation of ribosomal proteins in liver of meal-fed rats. American Journal of Physiology. Endocrinology and Metabolism. 281: E430-9. PMID 11500297  0.8
2001 Anthony TG, Anthony JC, Yoshizawa F, Kimball SR, Jefferson LS. Oral administration of leucine stimulates ribosomal protein mRNA translation but not global rates of protein synthesis in the liver of rats. The Journal of Nutrition. 131: 1171-6. PMID 11285321  0.8
2001 Anthony JC, Anthony TG, Kimball SR, Jefferson LS. Signaling pathways involved in translational control of protein synthesis in skeletal muscle by leucine. The Journal of Nutrition. 131: 856S-860S. PMID 11238774  0.8
2000 Shah OJ, Anthony JC, Kimball SR, Jefferson LS. Glucocorticoids oppose translational control by leucine in skeletal muscle. American Journal of Physiology. Endocrinology and Metabolism. 279: E1185-90. PMID 11052975  0.8
2000 Anthony JC, Yoshizawa F, Anthony TG, Vary TC, Jefferson LS, Kimball SR. Leucine stimulates translation initiation in skeletal muscle of postabsorptive rats via a rapamycin-sensitive pathway. The Journal of Nutrition. 130: 2413-9. PMID 11015466  0.8
2000 Shah OJ, Anthony JC, Kimball SR, Jefferson LS. 4E-BP1 and S6K1: translational integration sites for nutritional and hormonal information in muscle. American Journal of Physiology. Endocrinology and Metabolism. 279: E715-29. PMID 11001751  0.8
2000 Shah OJ, Kimball SR, Jefferson LS. Glucocorticoids abate p70(S6k) and eIF4E function in L6 skeletal myoblasts. American Journal of Physiology. Endocrinology and Metabolism. 279: E74-82. PMID 10893325  0.68
2000 Shah OJ, Kimball SR, Jefferson LS. Among translational effectors, p70S6k is uniquely sensitive to inhibition by glucocorticoids. The Biochemical Journal. 347: 389-97. PMID 10749668 DOI: 10.1042/0264-6021:3470389  0.68
2000 Anthony JC, Anthony TG, Kimball SR, Vary TC, Jefferson LS. Orally administered leucine stimulates protein synthesis in skeletal muscle of postabsorptive rats in association with increased eIF4F formation. The Journal of Nutrition. 130: 139-45. PMID 10720160  0.8
2000 Shah OJ, Kimball SR, Jefferson LS. Acute attenuation of translation initiation and protein synthesis by glucocorticoids in skeletal muscle. American Journal of Physiology. Endocrinology and Metabolism. 278: E76-82. PMID 10644539  0.68
1999 Farrell PA, Fedele MJ, Vary TC, Kimball SR, Lang CH, Jefferson LS. Regulation of protein synthesis after acute resistance exercise in diabetic rats. American Journal of Physiology. Endocrinology and Metabolism. 276: E721-E727. PMID 29591055 DOI: 10.1152/ajpendo.1999.276.4.E721  0.8
1999 Shah OJ, Antonetti DA, Kimball SR, Jefferson LS. Leucine, glutamine, and tyrosine reciprocally modulate the translation initiation factors eIF4F and eIF2B in perfused rat liver. The Journal of Biological Chemistry. 274: 36168-75. PMID 10593901 DOI: 10.1074/jbc.274.51.36168  0.68
1998 Fox HL, Pham PT, Kimball SR, Jefferson LS, Lynch CJ. Amino acid effects on translational repressor 4E-BP1 are mediated primarily by l-leucine in isolated adipocytes. American Journal of Physiology. Cell Physiology. 275: C1232-C1238. PMID 29585386 DOI: 10.1152/ajpcell.1998.275.5.C1232  0.8
1998 Yoshizawa F, Kimball SR, Vary TC, Jefferson LS. Effect of dietary protein on translation initiation in rat skeletal muscle and liver. American Journal of Physiology. Endocrinology and Metabolism. 275: E814-E820. PMID 29585217 DOI: 10.1152/ajpendo.1998.275.5.E814  0.8
1998 Fox HL, Kimball SR, Jefferson LS, Lynch CJ. Amino acids stimulate phosphorylation of p70and organization of rat adipocytes into multicellular clusters. American Journal of Physiology. Cell Physiology. 274: C206-C213. PMID 29585028 DOI: 10.1152/ajpcell.1998.274.1.C206  0.8
1998 Kimball SR, Horetsky RL, Jefferson LS. Signal transduction pathways involved in the regulation of protein synthesis by insulin in L6 myoblasts. American Journal of Physiology. Cell Physiology. 274: C221-C228. PMID 29585022 DOI: 10.1152/ajpcell.1998.274.1.C221  0.8
1998 Gautsch TA, Anthony JC, Kimball SR, Paul GL, Layman DK, Jefferson LS. Availability of eIF4E regulates skeletal muscle protein synthesis during recovery from exercise. The American Journal of Physiology. 274: C406-14. PMID 9486130  0.68
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