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Leonard S. Jefferson - Publications

Affiliations: 
Pennsylvania State University, State College, PA, United States 
Area:
Cell Biology
Website:
https://medschool.vanderbilt.edu/mpb/person/leonard-s-jim-jefferson-phd

244 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Kincheloe GN, Roberson PA, Toro AL, Stanley BA, Stanley AE, Jefferson LS, Dennis MD, Kimball SR. Loss of 4E-BPs Prevents the Hindlimb Immobilization-Induced Decrease in Protein Synthesis in Skeletal Muscle. Journal of Applied Physiology (Bethesda, Md. : 1985). PMID 36454675 DOI: 10.1152/japplphysiol.00563.2022  0.331
2022 Welles JE, Lacko H, Kawasawa YI, Dennis MD, Jefferson LS, Kimball SR. An integrative approach to assessing effects of a short-term Western diet on gene expression in rat liver. Frontiers in Endocrinology. 13: 1032293. PMID 36387860 DOI: 10.3389/fendo.2022.1032293  0.321
2022 Roberson PA, Jefferson LS, Kimball SR. Convergence of Signaling Pathways in Mediating Actions of Leucine and IGF-1 on mTORC1 in L6 Myoblasts. American Journal of Physiology. Cell Physiology. PMID 35912992 DOI: 10.1152/ajpcell.00183.2022  0.441
2020 Welles JE, Dennis MD, Jefferson LS, Kimball SR. Glucagon-Dependent Suppression of mTORC1 is Associated with Upregulation of Hepatic FGF21 mRNA Translation. American Journal of Physiology. Endocrinology and Metabolism. PMID 32421369 DOI: 10.1152/Ajpendo.00555.2019  0.428
2020 Roberson PA, Shimkus KL, Welles JE, Xu D, Whitsell AL, Kimball EM, Jefferson LS, Kimball SR. A Time Course for Markers of Protein Synthesis and Degradation with Hindlimb Unloading and the Accompanying Anabolic Resistance to Refeeding. Journal of Applied Physiology (Bethesda, Md. : 1985). PMID 32407240 DOI: 10.1152/Japplphysiol.00155.2020  0.407
2019 Xu D, Dai W, Kutzler L, Lacko HA, Jefferson LS, Dennis MD, Kimball SR. ATF4-Mediated Upregulation of REDD1 and Sestrin2 Suppresses mTORC1 Activity during Prolonged Leucine Deprivation. The Journal of Nutrition. PMID 31875479 DOI: 10.1093/Jn/Nxz309  0.372
2019 Xu D, Shimkus KL, Lacko HA, Kutzler L, Jefferson LS, Kimball SR. Evidence for a Role for Sestrin1 in Mediating Leucine-Induced Activation of mTORC1 in Skeletal Muscle. American Journal of Physiology. Endocrinology and Metabolism. PMID 30835510 DOI: 10.1152/Ajpendo.00522.2018  0.452
2019 Dierschke SK, Miller WP, Favate JS, Shah P, Imamura Kawasawa Y, Salzberg AC, Kimball SR, Jefferson LS, Dennis MD. O-GlcNAcylation alters the selection of mRNAs for translation and promotes 4E-BP1-dependent mitochondrial dysfunction in retina. The Journal of Biological Chemistry. PMID 30733333 DOI: 10.1074/Jbc.Ra119.007494  0.414
2018 Shimkus KL, Jefferson LS, Gordon BS, Kimball SR. Repressors of mTORC1 act to blunt the anabolic response to feeding in the soleus muscle of a cast-immobilized mouse hindlimb. Physiological Reports. 6: e13891. PMID 30338657 DOI: 10.14814/Phy2.13891  0.477
2016 Black AJ, Gordon BS, Dennis MD, Jefferson LS, Kimball SR. Regulation of protein and mRNA expression of the mTORC1 repressor REDD1 in response to leucine and serum. Biochemistry and Biophysics Reports. 8: 296-301. PMID 28367506 DOI: 10.1016/J.Bbrep.2016.10.003  0.456
2016 Gordon BS, Liu C, Steiner JL, Nader GA, Jefferson LS, Kimball SR. Loss of REDD1 Augments the Rate of the Overload-Induced Increase in Muscle Mass. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. ajpregu.00159.2016. PMID 27465734 DOI: 10.1152/Ajpregu.00159.2016  0.471
2016 Kimball SR, Gordon BS, Moyer JE, Dennis MD, Jefferson LS. Leucine induced dephosphorylation of Sestrin2 promotes mTORC1 activation. Cellular Signalling. PMID 27010498 DOI: 10.1016/J.Cellsig.2016.03.008  0.422
2016 Miller WP, Mihailescu ML, Yang C, Barber AJ, Kimball SR, Jefferson LS, Dennis MD. The Translational Repressor 4E-BP1 Contributes to Diabetes-Induced Visual Dysfunction. Investigative Ophthalmology & Visual Science. 57: 1327-1337. PMID 26998719 DOI: 10.1167/Iovs.15-18719  0.41
2016 Black AJ, Gordon BS, Dennis MD, Jefferson LS, Kimball SR. Regulation of protein and mRNA expression of the mTORC1 repressor REDD1 in response to leucine and serum Biochemistry and Biophysics Reports. 8: 296-301. DOI: 10.1016/j.bbrep.2016.10.003  0.352
2015 Kimball SR, Ravi S, Gordon BS, Dennis MD, Jefferson LS. Amino Acid-Induced Activation of mTORC1 in Rat Liver Is Attenuated by Short-Term Consumption of a High-Fat Diet. The Journal of Nutrition. 145: 2496-502. PMID 26400964 DOI: 10.3945/Jn.115.215491  0.315
2015 Gordon BS, Williamson DL, Lang CH, Jefferson LS, Kimball SR. Nutrient-induced stimulation of protein synthesis in mouse skeletal muscle is limited by the mTORC1 repressor REDD1. The Journal of Nutrition. 145: 708-13. PMID 25716553 DOI: 10.3945/Jn.114.207621  0.478
2015 Dennis MD, Kimball SR, Fort PE, Jefferson LS. Regulated in development and DNA damage 1 is necessary for hyperglycemia-induced vascular endothelial growth factor expression in the retina of diabetic rodents. The Journal of Biological Chemistry. 290: 3865-74. PMID 25548280 DOI: 10.1074/Jbc.M114.623058  0.443
2015 Kelleher AR, Pereira SL, Jefferson LS, Kimball SR. REDD2 expression in rat skeletal muscle correlates with nutrient-induced activation of mTORC1: responses to aging, immobilization, and remobilization. American Journal of Physiology. Endocrinology and Metabolism. 308: E122-9. PMID 25406262 DOI: 10.1152/Ajpendo.00341.2014  0.415
2014 Gordon BS, Steiner JL, Lang CH, Jefferson LS, Kimball SR. Reduced REDD1 expression contributes to activation of mTORC1 following electrically induced muscle contraction. American Journal of Physiology. Endocrinology and Metabolism. 307: E703-11. PMID 25159324 DOI: 10.1152/Ajpendo.00250.2014  0.464
2014 Dennis MD, Coleman CS, Berg A, Jefferson LS, Kimball SR. REDD1 enhances protein phosphatase 2A-mediated dephosphorylation of Akt to repress mTORC1 signaling. Science Signaling. 7: ra68. PMID 25056877 DOI: 10.1126/Scisignal.2005103  0.462
2014 Martin TD, Dennis MD, Gordon BS, Kimball SR, Jefferson LS. mTORC1 and JNK coordinate phosphorylation of the p70S6K1 autoinhibitory domain in skeletal muscle following functional overloading. American Journal of Physiology. Endocrinology and Metabolism. 306: E1397-405. PMID 24801387 DOI: 10.1152/Ajpendo.00064.2014  0.435
2014 Kelleher AR, Gordon BS, Kimball SR, Jefferson LS. Changes in REDD1, REDD2, and atrogene mRNA expression are prevented in skeletal muscle fixed in a stretched position during hindlimb immobilization. Physiological Reports. 2: e00246. PMID 24744910 DOI: 10.1002/Phy2.246  0.39
2014 Fort PE, Losiewicz MK, Pennathur S, Jefferson LS, Kimball SR, Abcouwer SF, Gardner TW. mTORC1-independent reduction of retinal protein synthesis in type 1 diabetes. Diabetes. 63: 3077-90. PMID 24740573 DOI: 10.2337/Db14-0235  0.468
2014 Gordon BS, Kazi AA, Coleman CS, Dennis MD, Chau V, Jefferson LS, Kimball SR. RhoA modulates signaling through the mechanistic target of rapamycin complex 1 (mTORC1) in mammalian cells. Cellular Signalling. 26: 461-7. PMID 24316235 DOI: 10.1016/J.Cellsig.2013.11.035  0.415
2014 Martin T, Dennis M, Gordon B, Kimball S, Jefferson L. An investigation of kinases responsible for site-specific phosphorylation of p70S6K1 in skeletal muscle following chronic functional overloading (1163.13) The Faseb Journal. 28. DOI: 10.1096/Fasebj.28.1_Supplement.1163.13  0.382
2013 Dennis MD, McGhee NK, Jefferson LS, Kimball SR. Regulated in DNA damage and development 1 (REDD1) promotes cell survival during serum deprivation by sustaining repression of signaling through the mechanistic target of rapamycin in complex 1 (mTORC1). Cellular Signalling. 25: 2709-16. PMID 24018049 DOI: 10.1016/J.Cellsig.2013.08.038  0.385
2013 Nie J, Liu X, Lilley BN, Zhang H, Pan YA, Kimball SR, Zhang J, Zhang W, Wang L, Jefferson LS, Sanes JR, Han X, Shi Y. SAD-A kinase controls islet β-cell size and function as a mediator of mTORC1 signaling. Proceedings of the National Academy of Sciences of the United States of America. 110: 13857-62. PMID 23922392 DOI: 10.1073/Pnas.1307698110  0.485
2013 Tuckow AP, Kazi AA, Kimball SR, Jefferson LS. Identification of ubiquitin-modified lysine residues and novel phosphorylation sites on eukaryotic initiation factor 2B epsilon. Biochemical and Biophysical Research Communications. 436: 41-6. PMID 23707720 DOI: 10.1016/J.Bbrc.2013.05.053  0.781
2013 Dennis MD, Shenberger JS, Stanley BA, Kimball SR, Jefferson LS. Hyperglycemia mediates a shift from cap-dependent to cap-independent translation via a 4E-BP1-dependent mechanism. Diabetes. 62: 2204-14. PMID 23434932 DOI: 10.2337/Db12-1453  0.487
2013 Kelleher AR, Kimball SR, Dennis MD, Schilder RJ, Jefferson LS. The mTORC1 signaling repressors REDD1/2 are rapidly induced and activation of p70S6K1 by leucine is defective in skeletal muscle of an immobilized rat hindlimb. American Journal of Physiology. Endocrinology and Metabolism. 304: E229-36. PMID 23193052 DOI: 10.1152/Ajpendo.00409.2012  0.528
2013 Dennis MD, Kimball SR, Jefferson LS. Mechanistic target of rapamycin complex 1 (mTORC1)-mediated phosphorylation is governed by competition between substrates for interaction with raptor. The Journal of Biological Chemistry. 288: 10-9. PMID 23184952 DOI: 10.1074/Jbc.M112.402461  0.376
2012 Dennis MD, Jefferson LS, Kimball SR. Role of p70S6K1-mediated phosphorylation of eIF4B and PDCD4 proteins in the regulation of protein synthesis. The Journal of Biological Chemistry. 287: 42890-9. PMID 23105104 DOI: 10.1074/Jbc.M112.404822  0.575
2012 Kimball SR, Jefferson LS. Induction of REDD1 gene expression in the liver in response to endoplasmic reticulum stress is mediated through a PERK, eIF2α phosphorylation, ATF4-dependent cascade. Biochemical and Biophysical Research Communications. 427: 485-9. PMID 23000413 DOI: 10.1016/J.Bbrc.2012.09.074  0.416
2012 Schilder RJ, Kimball SR, Jefferson LS. Cell-autonomous regulation of fast troponin T pre-mRNA alternative splicing in response to mechanical stretch. American Journal of Physiology. Cell Physiology. 303: C298-307. PMID 22592404 DOI: 10.1152/Ajpcell.00400.2011  0.435
2011 Kumari R, Willing LB, Jefferson LS, Simpson IA, Kimball SR. REDD1 (regulated in development and DNA damage response 1) expression in skeletal muscle as a surrogate biomarker of the efficiency of glucocorticoid receptor blockade. Biochemical and Biophysical Research Communications. 412: 644-7. PMID 21856283 DOI: 10.1016/J.Bbrc.2011.08.017  0.37
2011 Dennis MD, Schrufer TL, Bronson SK, Kimball SR, Jefferson LS. Hyperglycemia-induced O-GlcNAcylation and truncation of 4E-BP1 protein in liver of a mouse model of type 1 diabetes. The Journal of Biological Chemistry. 286: 34286-97. PMID 21840999 DOI: 10.1074/Jbc.M111.259457  0.798
2011 Winter JN, Jefferson LS, Kimball SR. ERK and Akt signaling pathways function through parallel mechanisms to promote mTORC1 signaling. American Journal of Physiology. Cell Physiology. 300: C1172-80. PMID 21289294 DOI: 10.1152/Ajpcell.00504.2010  0.671
2011 Dennis MD, Baum JI, Kimball SR, Jefferson LS. Mechanisms involved in the coordinate regulation of mTORC1 by insulin and amino acids. The Journal of Biological Chemistry. 286: 8287-96. PMID 21239491 DOI: 10.1074/Jbc.M110.209171  0.411
2011 Tuckow AP, Jefferson SJ, Kimball SR, Jefferson LS. Simvastatin represses protein synthesis in the muscle-derived C₂C₁₂ cell line with a concomitant reduction in eukaryotic initiation factor 2B expression. American Journal of Physiology. Endocrinology and Metabolism. 300: E564-70. PMID 21224482 DOI: 10.1152/Ajpendo.00383.2010  0.822
2011 Jefferson LS, Vary TC, Kimball SR. Regulation of Protein Metabolism in Muscle Comprehensive Physiology. 529-552. DOI: 10.1002/Cphy.Cp070216  0.497
2010 Kimball SR, Jefferson LS. Control of translation initiation through integration of signals generated by hormones, nutrients, and exercise. The Journal of Biological Chemistry. 285: 29027-32. PMID 20576612 DOI: 10.1074/Jbc.R110.137208  0.523
2010 Schrufer TL, Antonetti DA, Sonenberg N, Kimball SR, Gardner TW, Jefferson LS. Ablation of 4E-BP1/2 prevents hyperglycemia-mediated induction of VEGF expression in the rodent retina and in Muller cells in culture. Diabetes. 59: 2107-16. PMID 20547975 DOI: 10.2337/Db10-0148  0.785
2010 Tuckow AP, Vary TC, Kimball SR, Jefferson LS. Ectopic expression of eIF2Bepsilon in rat skeletal muscle rescues the sepsis-induced reduction in guanine nucleotide exchange activity and protein synthesis. American Journal of Physiology. Endocrinology and Metabolism. 299: E241-8. PMID 20484009 DOI: 10.1152/Ajpendo.00151.2010  0.808
2010 Winter JN, Fox TE, Kester M, Jefferson LS, Kimball SR. Phosphatidic acid mediates activation of mTORC1 through the ERK signaling pathway. American Journal of Physiology. Cell Physiology. 299: C335-44. PMID 20427710 DOI: 10.1152/Ajpcell.00039.2010  0.659
2010 Harding SV, Adegoke OA, Fraser KG, Marliss EB, Chevalier S, Kimball SR, Jefferson LS, Wykes LJ. Maintaining adequate nutrition, not probiotic administration, prevents growth stunting and maintains skeletal muscle protein synthesis rates in a piglet model of colitis. Pediatric Research. 67: 268-73. PMID 19952868 DOI: 10.1203/Pdr.0B013E3181Cb8E49  0.431
2009 Baum JI, Kimball SR, Jefferson LS. Glucagon acts in a dominant manner to repress insulin-induced mammalian target of rapamycin complex 1 signaling in perfused rat liver. American Journal of Physiology. Endocrinology and Metabolism. 297: E410-5. PMID 19509187 DOI: 10.1152/Ajpendo.00042.2009  0.447
2009 Dang Do AN, Kimball SR, Cavener DR, Jefferson LS. eIF2alpha kinases GCN2 and PERK modulate transcription and translation of distinct sets of mRNAs in mouse liver. Physiological Genomics. 38: 328-41. PMID 19509078 DOI: 10.1152/Physiolgenomics.90396.2008  0.797
2009 McGhee NK, Jefferson LS, Kimball SR. Elevated corticosterone associated with food deprivation upregulates expression in rat skeletal muscle of the mTORC1 repressor, REDD1. The Journal of Nutrition. 139: 828-34. PMID 19297425 DOI: 10.3945/Jn.108.099846  0.439
2009 Zhang L, Kimball SR, Jefferson LS, Shenberger JS. Hydrogen peroxide impairs insulin-stimulated assembly of mTORC1. Free Radical Biology & Medicine. 46: 1500-9. PMID 19281842 DOI: 10.1016/J.Freeradbiomed.2009.03.001  0.461
2009 Whitney ML, Jefferson LS, Kimball SR. ATF4 is necessary and sufficient for ER stress-induced upregulation of REDD1 expression. Biochemical and Biophysical Research Communications. 379: 451-5. PMID 19114033 DOI: 10.1016/J.Bbrc.2008.12.079  0.311
2009 Adegoke OA, Chevalier S, Morais JA, Gougeon R, Kimball SR, Jefferson LS, Wing SS, Marliss EB. Fed-state clamp stimulates cellular mechanisms of muscle protein anabolism and modulates glucose disposal in normal men. American Journal of Physiology. Endocrinology and Metabolism. 296: E105-13. PMID 18957614 DOI: 10.1152/Ajpendo.90752.2008  0.472
2008 Gallagher JW, Kubica N, Kimball SR, Jefferson LS. Reduced eukaryotic initiation factor 2Bepsilon-subunit expression suppresses the transformed phenotype of cells overexpressing the protein. Cancer Research. 68: 8752-60. PMID 18974117 DOI: 10.1158/0008-5472.Can-08-1042  0.793
2008 Dardevet D, Kimball SR, Jefferson LS, Cherrington AD, Rémond D, DiCostanzo CA, Moore MC. Portal infusion of amino acids is more efficient than peripheral infusion in stimulating liver protein synthesis at the same hepatic amino acid load in dogs. The American Journal of Clinical Nutrition. 88: 986-96. PMID 18842785 DOI: 10.1093/Ajcn/88.4.986  0.316
2008 Reiter AK, Bolster DR, Crozier SJ, Kimball SR, Jefferson LS. AMPK represses TOP mRNA translation but not global protein synthesis in liver. Biochemical and Biophysical Research Communications. 374: 345-50. PMID 18638456 DOI: 10.1016/J.Bbrc.2008.07.025  0.852
2008 Orellana RA, Suryawan A, Kimball SR, Wu G, Nguyen HV, Jefferson LS, Davis TA. Insulin signaling in skeletal muscle and liver of neonatal pigs during endotoxemia. Pediatric Research. 64: 505-10. PMID 18596577 DOI: 10.1203/Pdr.0B013E318183Fd4C  0.459
2008 Kubica N, Crispino JL, Gallagher JW, Kimball SR, Jefferson LS. Activation of the mammalian target of rapamycin complex 1 is both necessary and sufficient to stimulate eukaryotic initiation factor 2Bvarepsilon mRNA translation and protein synthesis. The International Journal of Biochemistry & Cell Biology. 40: 2522-33. PMID 18556237 DOI: 10.1016/J.Biocel.2008.04.010  0.829
2008 Kimball SR, Abbas A, Jefferson LS. Melatonin represses oxidative stress-induced activation of the MAP kinase and mTOR signaling pathways in H4IIE hepatoma cells through inhibition of Ras. Journal of Pineal Research. 44: 379-86. PMID 18410586 DOI: 10.1111/J.1600-079X.2007.00539.X  0.361
2008 Kimball SR, Do AN, Kutzler L, Cavener DR, Jefferson LS. Rapid turnover of the mTOR complex 1 (mTORC1) repressor REDD1 and activation of mTORC1 signaling following inhibition of protein synthesis. The Journal of Biological Chemistry. 283: 3465-75. PMID 18070882 DOI: 10.1074/Jbc.M706643200  0.523
2007 Shaheen HH, Horetsky RL, Kimball SR, Murthi A, Jefferson LS, Hopper AK. Retrograde nuclear accumulation of cytoplasmic tRNA in rat hepatoma cells in response to amino acid deprivation. Proceedings of the National Academy of Sciences of the United States of America. 104: 8845-50. PMID 17502605 DOI: 10.1073/Pnas.0700765104  0.315
2007 Vary TC, Anthony JC, Jefferson LS, Kimball SR, Lynch CJ. Rapamycin blunts nutrient stimulation of eIF4G, but not PKCepsilon phosphorylation, in skeletal muscle. American Journal of Physiology. Endocrinology and Metabolism. 293: E188-96. PMID 17389711 DOI: 10.1152/Ajpendo.00037.2007  0.775
2007 Krawiec BJ, Nystrom GJ, Frost RA, Jefferson LS, Lang CH. AMP-activated protein kinase agonists increase mRNA content of the muscle-specific ubiquitin ligases MAFbx and MuRF1 in C2C12 cells. American Journal of Physiology. Endocrinology and Metabolism. 292: E1555-67. PMID 17264220 DOI: 10.1152/Ajpendo.00622.2006  0.492
2007 Orellana RA, Kimball SR, Suryawan A, Escobar J, Nguyen HV, Jefferson LS, Davis TA. Insulin stimulates muscle protein synthesis in neonates during endotoxemia despite repression of translation initiation. American Journal of Physiology. Endocrinology and Metabolism. 292: E629-36. PMID 17047163 DOI: 10.1152/Ajpendo.00214.2006  0.455
2007 Frost RA, Nystrom GJ, Jefferson LS, Lang CH. Hormone, cytokine, and nutritional regulation of sepsis-induced increases in atrogin-1 and MuRF1 in skeletal muscle. American Journal of Physiology. Endocrinology and Metabolism. 292: E501-12. PMID 17003238 DOI: 10.1152/Ajpendo.00359.2006  0.479
2007 Manni A, Rager T, Kimball SR, Jefferson LS, Washington S, Hu X, Verderame MF. Effects of α-difluoromethylornithine on thrombospondin-1 production by human breast cancer cells International Journal of Oncology. 31: 1187-1191. DOI: 10.3892/Ijo.31.5.1187  0.399
2007 Gallagher JW, Kubica N, Kimball S, Jefferson L. eIF2B‐epsilon is translationally regulated through a mTOR‐dependent signaling pathway The Faseb Journal. 21. DOI: 10.1096/Fasebj.21.5.A651-C  0.761
2007 Gallagher JW, Kubica N, Kimball SR, Jefferson LS. Repressed eIF2B‐epsilon expression delays tumor growth in transformed mouse embryonic fibroblasts (TMEF) The Faseb Journal. 21. DOI: 10.1096/Fasebj.21.5.A651-B  0.737
2007 Kimball SR, Wang H, Kubica N, Ellisen LW, Jefferson LS. Dexamethasone represses signaling through mammalian target of rapamycin (mTOR) in muscle cells by enhancing expression of REDD1 The Faseb Journal. 21. DOI: 10.1096/Fasebj.21.5.A651-A  0.781
2006 Wang H, Kubica N, Ellisen LW, Jefferson LS, Kimball SR. Dexamethasone represses signaling through the mammalian target of rapamycin in muscle cells by enhancing expression of REDD1. The Journal of Biological Chemistry. 281: 39128-34. PMID 17074751 DOI: 10.1074/Jbc.M610023200  0.819
2006 Antonetti DA, Barber AJ, Bronson SK, Freeman WM, Gardner TW, Jefferson LS, Kester M, Kimball SR, Krady JK, LaNoue KF, Norbury CC, Quinn PG, Sandirasegarane L, Simpson IA. Diabetic retinopathy: seeing beyond glucose-induced microvascular disease. Diabetes. 55: 2401-11. PMID 16936187 DOI: 10.2337/Db05-1635  0.568
2006 Kubica N, Jefferson LS, Kimball SR. Eukaryotic initiation factor 2B and its role in alterations in mRNA translation that occur under a number of pathophysiological and physiological conditions. Progress in Nucleic Acid Research and Molecular Biology. 81: 271-96. PMID 16891174 DOI: 10.1016/S0079-6603(06)81007-X  0.816
2006 Williamson DL, Bolster DR, Kimball SR, Jefferson LS. Time course changes in signaling pathways and protein synthesis in C2C12 myotubes following AMPK activation by AICAR. American Journal of Physiology. Endocrinology and Metabolism. 291: E80-9. PMID 16760336 DOI: 10.1152/Ajpendo.00566.2005  0.574
2006 Crozier SJ, Zhang X, Wang J, Cheung J, Kimball SR, Jefferson LS. Activation of signaling pathways and regulatory mechanisms of mRNA translation following myocardial ischemia-reperfusion. Journal of Applied Physiology (Bethesda, Md. : 1985). 101: 576-82. PMID 16690784 DOI: 10.1152/Japplphysiol.01122.2005  0.524
2006 Williamson DL, Kubica N, Kimball SR, Jefferson LS. Exercise-induced alterations in extracellular signal-regulated kinase 1/2 and mammalian target of rapamycin (mTOR) signalling to regulatory mechanisms of mRNA translation in mouse muscle. The Journal of Physiology. 573: 497-510. PMID 16543272 DOI: 10.1113/Jphysiol.2005.103481  0.835
2006 Kimball SR, Jefferson LS. New functions for amino acids: effects on gene transcription and translation. The American Journal of Clinical Nutrition. 83: 500S-507S. PMID 16470021 DOI: 10.1093/Ajcn/83.2.500S  0.479
2006 Palmer LK, Rannels SL, Kimball SR, Jefferson LS, Keil RL. Inhibition of mammalian translation initiation by volatile anesthetics. American Journal of Physiology. Endocrinology and Metabolism. 290: E1267-75. PMID 16434554 DOI: 10.1152/Ajpendo.00463.2005  0.499
2006 Kimball SR, Jefferson LS. Signaling pathways and molecular mechanisms through which branched-chain amino acids mediate translational control of protein synthesis. The Journal of Nutrition. 136: 227S-31S. PMID 16365087 DOI: 10.1093/Jn/136.1.227S  0.581
2006 Kline CL, Schrufer TL, Jefferson LS, Kimball SR. Glucosamine-induced phosphorylation of the alpha-subunit of eukaryotic initiation factor 2 is mediated by the protein kinase R-like endoplasmic-reticulum associated kinase. The International Journal of Biochemistry & Cell Biology. 38: 1004-14. PMID 16324875 DOI: 10.1016/J.Biocel.2005.10.015  0.804
2006 Escobar J, Frank JW, Suryawan A, Nguyen HV, Kimball SR, Jefferson LS, Davis TA. Regulation of cardiac and skeletal muscle protein synthesis by individual branched-chain amino acids in neonatal pigs. American Journal of Physiology. Endocrinology and Metabolism. 290: E612-21. PMID 16278252 DOI: 10.1152/Ajpendo.00402.2005  0.501
2006 Frank JW, Escobar J, Suryawan A, Nguyen HV, Kimball SR, Jefferson LS, Davis TA. Dietary protein and lactose increase translation initiation factor activation and tissue protein synthesis in neonatal pigs. American Journal of Physiology. Endocrinology and Metabolism. 290: E225-33. PMID 16144813 DOI: 10.1152/Ajpendo.00351.2005  0.487
2005 Krawiec BJ, Frost RA, Vary TC, Jefferson LS, Lang CH. Hindlimb casting decreases muscle mass in part by proteasome-dependent proteolysis but independent of protein synthesis. American Journal of Physiology. Endocrinology and Metabolism. 289: E969-80. PMID 16046454 DOI: 10.1152/Ajpendo.00126.2005  0.474
2005 Frank JW, Escobar J, Suryawan A, Kimball SR, Nguyen HV, Jefferson LS, Davis TA. Protein synthesis and translation initiation factor activation in neonatal pigs fed increasing levels of dietary protein. The Journal of Nutrition. 135: 1374-81. PMID 15930440 DOI: 10.1093/Jn/135.6.1374  0.503
2005 Crozier SJ, Vary TC, Kimball SR, Jefferson LS. Cellular energy status modulates translational control mechanisms in ischemic-reperfused rat hearts. American Journal of Physiology. Heart and Circulatory Physiology. 289: H1242-50. PMID 15894572 DOI: 10.1152/Ajpheart.00859.2004  0.411
2005 Crozier SJ, Kimball SR, Emmert SW, Anthony JC, Jefferson LS. Oral leucine administration stimulates protein synthesis in rat skeletal muscle. The Journal of Nutrition. 135: 376-82. PMID 15735066 DOI: 10.1093/Jn/135.3.376  0.808
2005 Reiter AK, Crozier SJ, Kimball SR, Jefferson LS. Meal feeding alters translational control of gene expression in rat liver. The Journal of Nutrition. 135: 367-75. PMID 15735065 DOI: 10.1093/Jn/135.3.367  0.848
2005 Williamson DL, Kimball SR, Jefferson LS. Acute treatment with TNF-alpha attenuates insulin-stimulated protein synthesis in cultures of C2C12 myotubes through a MEK1-sensitive mechanism. American Journal of Physiology. Endocrinology and Metabolism. 289: E95-104. PMID 15701678 DOI: 10.1152/Ajpendo.00397.2004  0.491
2005 Kimball SR, Jefferson LS. Role of amino acids in the translational control of protein synthesis in mammals. Seminars in Cell & Developmental Biology. 16: 21-7. PMID 15659336 DOI: 10.1016/J.Semcdb.2004.11.009  0.45
2005 Escobar J, Frank JW, Suryawan A, Nguyen HV, Kimball SR, Jefferson LS, Davis TA. Physiological rise in plasma leucine stimulates muscle protein synthesis in neonatal pigs by enhancing translation initiation factor activation. American Journal of Physiology. Endocrinology and Metabolism. 288: E914-21. PMID 15644455 DOI: 10.1152/Ajpendo.00510.2004  0.538
2005 Reiter AK, Bolster DR, Crozier SJ, Kimball SR, Jefferson LS. Repression of protein synthesis and mTOR signaling in rat liver mediated by the AMPK activator aminoimidazole carboxamide ribonucleoside. American Journal of Physiology. Endocrinology and Metabolism. 288: E980-8. PMID 15613684 DOI: 10.1152/Ajpendo.00333.2004  0.85
2005 Kubica N, Bolster DR, Farrell PA, Kimball SR, Jefferson LS. Resistance exercise increases muscle protein synthesis and translation of eukaryotic initiation factor 2Bepsilon mRNA in a mammalian target of rapamycin-dependent manner. The Journal of Biological Chemistry. 280: 7570-80. PMID 15591312 DOI: 10.1074/Jbc.M413732200  0.842
2004 Prod'homme M, Balage M, Debras E, Farges MC, Kimball S, Jefferson L, Grizard J. Differential effects of insulin and dietary amino acids on muscle protein synthesis in adult and old rats. The Journal of Physiology. 563: 235-48. PMID 15513948 DOI: 10.1113/Jphysiol.2004.068841  0.509
2004 Kimball SR, Jefferson LS. Amino acids as regulators of gene expression. Nutrition & Metabolism. 1: 3. PMID 15507151 DOI: 10.1186/1743-7075-1-3  0.407
2004 Kimball SR, Siegfried BA, Jefferson LS. Glucagon represses signaling through the mammalian target of rapamycin in rat liver by activating AMP-activated protein kinase. The Journal of Biological Chemistry. 279: 54103-9. PMID 15494402 DOI: 10.1074/Jbc.M410755200  0.529
2004 Goggin MM, Nelsen CJ, Kimball SR, Jefferson LS, Morley SJ, Albrecht JH. Rapamycin-sensitive induction of eukaryotic initiation factor 4F in regenerating mouse liver. Hepatology (Baltimore, Md.). 40: 537-44. PMID 15349891 DOI: 10.1002/Hep.20338  0.499
2004 Reiter AK, Anthony TG, Anthony JC, Jefferson LS, Kimball SR. The mTOR signaling pathway mediates control of ribosomal protein mRNA translation in rat liver. The International Journal of Biochemistry & Cell Biology. 36: 2169-79. PMID 15313464 DOI: 10.1016/J.Biocel.2004.04.004  0.834
2004 Bolster DR, Jefferson LS, Kimball SR. Regulation of protein synthesis associated with skeletal muscle hypertrophy by insulin-, amino acid- and exercise-induced signalling. The Proceedings of the Nutrition Society. 63: 351-6. PMID 15294054 DOI: 10.1079/PNS2004355  0.437
2004 Bolster DR, Vary TC, Kimball SR, Jefferson LS. Leucine regulates translation initiation in rat skeletal muscle via enhanced eIF4G phosphorylation. The Journal of Nutrition. 134: 1704-10. PMID 15226457 DOI: 10.1093/Jn/134.7.1704  0.553
2004 Kimball SR, O'Malley JP, Anthony JC, Crozier SJ, Jefferson LS. Assessment of biomarkers of protein anabolism in skeletal muscle during the life span of the rat: sarcopenia despite elevated protein synthesis. American Journal of Physiology. Endocrinology and Metabolism. 287: E772-80. PMID 15187001 DOI: 10.1152/Ajpendo.00535.2003  0.778
2004 Kimball SR, Jefferson LS. Molecular mechanisms through which amino acids mediate signaling through the mammalian target of rapamycin. Current Opinion in Clinical Nutrition and Metabolic Care. 7: 39-44. PMID 15090902 DOI: 10.1097/00075197-200401000-00008  0.424
2004 O'Connor PM, Kimball SR, Suryawan A, Bush JA, Nguyen HV, Jefferson LS, Davis TA. Regulation of neonatal liver protein synthesis by insulin and amino acids in pigs. American Journal of Physiology. Endocrinology and Metabolism. 286: E994-E1003. PMID 14761876 DOI: 10.1152/Ajpendo.00391.2003  0.443
2004 Kimball SR, Horetsky RL, Jefferson LS. A microtiter plate assay for assessing the interaction of eukaryotic initiation factor eIF4E with eIF4G and eIF4E binding protein-1. Analytical Biochemistry. 325: 364-8. PMID 14751272 DOI: 10.1016/J.Ab.2003.11.016  0.465
2004 Suryawan A, O'Connor PM, Kimball SR, Bush JA, Nguyen HV, Jefferson LS, Davis TA. Amino acids do not alter the insulin-induced activation of the insulin signaling pathway in neonatal pigs. The Journal of Nutrition. 134: 24-30. PMID 14704288 DOI: 10.1093/Jn/134.1.24  0.469
2004 Kimball SR, Jefferson LS. Regulation of global and specific mRNA translation by oral administration of branched-chain amino acids. Biochemical and Biophysical Research Communications. 313: 423-7. PMID 14684179 DOI: 10.1016/J.Bbrc.2003.07.014  0.6
2004 Orellana RA, Kimball SR, Nguyen HV, Bush JA, Suryawan A, Thivierge MC, Jefferson LS, Davis TA. Regulation of muscle protein synthesis in neonatal pigs during prolonged endotoxemia. Pediatric Research. 55: 442-9. PMID 14681494 DOI: 10.1203/01.Pdr.0000110526.02282.F3  0.523
2004 Wu X, Reiter CE, Antonetti DA, Kimball SR, Jefferson LS, Gardner TW. Insulin promotes rat retinal neuronal cell survival in a p70S6K-dependent manner. The Journal of Biological Chemistry. 279: 9167-75. PMID 14660591 DOI: 10.1074/Jbc.M312397200  0.655
2004 Kubica N, Kimball SR, Jefferson LS, Farrell PA. Alterations in the expression of mRNAs and proteins that code for species relevant to eIF2B activity after an acute bout of resistance exercise. Journal of Applied Physiology (Bethesda, Md. : 1985). 96: 679-87. PMID 14565967 DOI: 10.1152/Japplphysiol.00962.2003  0.819
2004 Farrell PA, Kubica N, Bolster DR, Crozier SJ, Kimball SR, Jefferson LS. Phosphorylation of Ser535 on eIF2Bϵ may be Important for Elevations in Muscle Protein Synthesis After Resistance Exercise in Rats Medicine & Science in Sports & Exercise. 36: S183. DOI: 10.1097/00005768-200405001-00878  0.811
2003 Lang CH, Frost RA, Deshpande N, Kumar V, Vary TC, Jefferson LS, Kimball SR. Alcohol impairs leucine-mediated phosphorylation of 4E-BP1, S6K1, eIF4G, and mTOR in skeletal muscle. American Journal of Physiology. Endocrinology and Metabolism. 285: E1205-15. PMID 12944322 DOI: 10.1152/Ajpendo.00177.2003  0.555
2003 Bolster DR, Kubica N, Crozier SJ, Williamson DL, Farrell PA, Kimball SR, Jefferson LS. Immediate response of mammalian target of rapamycin (mTOR)-mediated signalling following acute resistance exercise in rat skeletal muscle. The Journal of Physiology. 553: 213-20. PMID 12937293 DOI: 10.1113/Jphysiol.2003.047019  0.824
2003 Bolster DR, Kimball SR, Jefferson LS. Translational control mechanisms modulate skeletal muscle gene expression during hypertrophy. Exercise and Sport Sciences Reviews. 31: 111-6. PMID 12882475 DOI: 10.1097/00003677-200307000-00002  0.432
2003 Crozier SJ, Anthony JC, Schworer CM, Reiter AK, Anthony TG, Kimball SR, Jefferson LS. Tissue-specific regulation of protein synthesis by insulin and free fatty acids. American Journal of Physiology. Endocrinology and Metabolism. 285: E754-62. PMID 12837665 DOI: 10.1152/Ajpendo.00063.2003  0.825
2003 Kimball SR, Orellana RA, O'Connor PM, Suryawan A, Bush JA, Nguyen HV, Thivierge MC, Jefferson LS, Davis TA. Endotoxin induces differential regulation of mTOR-dependent signaling in skeletal muscle and liver of neonatal pigs. American Journal of Physiology. Endocrinology and Metabolism. 285: E637-44. PMID 12773308 DOI: 10.1152/Ajpendo.00340.2002  0.553
2003 Jefferson LS, Kimball SR. Amino acids as regulators of gene expression at the level of mRNA translation. The Journal of Nutrition. 133: 2046S-2051S. PMID 12771363 DOI: 10.1093/Jn/133.6.2046S  0.495
2003 Bush JA, Kimball SR, O'Connor PM, Suryawan A, Orellana RA, Nguyen HV, Jefferson LS, Davis TA. Translational control of protein synthesis in muscle and liver of growth hormone-treated pigs. Endocrinology. 144: 1273-83. PMID 12639910 DOI: 10.1210/En.2002-220983  0.546
2003 O'Connor PM, Kimball SR, Suryawan A, Bush JA, Nguyen HV, Jefferson LS, Davis TA. Regulation of translation initiation by insulin and amino acids in skeletal muscle of neonatal pigs. American Journal of Physiology. Endocrinology and Metabolism. 285: E40-53. PMID 12637260 DOI: 10.1152/Ajpendo.00563.2002  0.495
2003 Kobayashi H, Børsheim E, Anthony TG, Traber DL, Badalamenti J, Kimball SR, Jefferson LS, Wolfe RR. Reduced amino acid availability inhibits muscle protein synthesis and decreases activity of initiation factor eIF2B. American Journal of Physiology. Endocrinology and Metabolism. 284: E488-98. PMID 12556349 DOI: 10.1152/Ajpendo.00094.2002  0.447
2003 Kimball SR, Horetsky RL, Ron D, Jefferson LS, Harding HP. Mammalian stress granules represent sites of accumulation of stalled translation initiation complexes. American Journal of Physiology. Cell Physiology. 284: C273-84. PMID 12388085 DOI: 10.1152/Ajpcell.00314.2002  0.393
2003 Kubica N, Kimball SR, Jefferson LS, Farrell PA. ALTERATIONS IN mRNA CODING FOR EIF2B EPSILON AND ITS UPSTREAM KINASES FOLLOWING AN ACUTE BOUT OF RESISTANCE EXERCISE Medicine & Science in Sports & Exercise. 35: S196. DOI: 10.1097/00005768-200305001-01092  0.781
2002 Crozier SJ, Bolster DR, Reiter AK, Kimball SR, Jefferson LS. Beta -oxidation of free fatty acids is required to maintain translational control of protein synthesis in heart. American Journal of Physiology. Endocrinology and Metabolism. 283: E1144-50. PMID 12388121 DOI: 10.1152/Ajpendo.00277.2002  0.843
2002 Zhang P, McGrath BC, Reinert J, Olsen DS, Lei L, Gill S, Wek SA, Vattem KM, Wek RC, Kimball SR, Jefferson LS, Cavener DR. The GCN2 eIF2alpha kinase is required for adaptation to amino acid deprivation in mice. Molecular and Cellular Biology. 22: 6681-8. PMID 12215525 DOI: 10.1128/Mcb.22.19.6681-6688.2002  0.328
2002 Kimball SR, Farrell PA, Jefferson LS. Invited Review: Role of insulin in translational control of protein synthesis in skeletal muscle by amino acids or exercise. Journal of Applied Physiology (Bethesda, Md. : 1985). 93: 1168-80. PMID 12183515 DOI: 10.1152/Japplphysiol.00221.2002  0.523
2002 Lynch CJ, Patson BJ, Anthony J, Vaval A, Jefferson LS, Vary TC. Leucine is a direct-acting nutrient signal that regulates protein synthesis in adipose tissue. American Journal of Physiology. Endocrinology and Metabolism. 283: E503-13. PMID 12169444 DOI: 10.1152/Ajpendo.00084.2002  0.767
2002 Shah OJ, Kimball SR, Jefferson LS. The Src-family tyrosine kinase inhibitor PP1 interferes with the activation of ribosomal protein S6 kinases. The Biochemical Journal. 366: 57-62. PMID 12014987 DOI: 10.1042/Bj20020198  0.73
2002 Bolster DR, Crozier SJ, Kimball SR, Jefferson LS. AMP-activated protein kinase suppresses protein synthesis in rat skeletal muscle through down-regulated mammalian target of rapamycin (mTOR) signaling. The Journal of Biological Chemistry. 277: 23977-80. PMID 11997383 DOI: 10.1074/Jbc.C200171200  0.559
2002 Anthony JC, Lang CH, Crozier SJ, Anthony TG, MacLean DA, Kimball SR, Jefferson LS. Contribution of insulin to the translational control of protein synthesis in skeletal muscle by leucine. American Journal of Physiology. Endocrinology and Metabolism. 282: E1092-101. PMID 11934675 DOI: 10.1152/Ajpendo.00208.2001  0.798
2002 Anthony JC, Reiter AK, Anthony TG, Crozier SJ, Lang CH, MacLean DA, Kimball SR, Jefferson LS. Orally administered leucine enhances protein synthesis in skeletal muscle of diabetic rats in the absence of increases in 4E-BP1 or S6K1 phosphorylation. Diabetes. 51: 928-36. PMID 11916909 DOI: 10.2337/Diabetes.51.4.928  0.838
2002 Kimball SR, Farrell PA, Nguyen HV, Jefferson LS, Davis TA. Developmental decline in components of signal transduction pathways regulating protein synthesis in pig muscle. American Journal of Physiology. Endocrinology and Metabolism. 282: E585-92. PMID 11832361 DOI: 10.1152/Ajpendo.00269.2001  0.526
2002 Kimball SR, Jefferson LS. Control of protein synthesis by amino acid availability. Current Opinion in Clinical Nutrition and Metabolic Care. 5: 63-7. PMID 11790952 DOI: 10.1097/00075197-200201000-00012  0.558
2002 Shah OJ, Iniguez-Lluhi JA, Romanelli A, Kimball SR, Jefferson LS. The activated glucocorticoid receptor modulates presumptive autoregulation of ribosomal protein S6 protein kinase, p70 S6K. The Journal of Biological Chemistry. 277: 2525-33. PMID 11705993 DOI: 10.1074/Jbc.M105935200  0.77
2001 Jefferson LS, Kimball SR. Translational control of protein synthesis: Implications for understanding changes in skeletal muscle mass International Journal of Sport Nutrition. 11. PMID 11915913 DOI: 10.1123/Ijsnem.11.S1.S143  0.527
2001 Vary TC, Jefferson LS, Kimball SR. Insulin fails to stimulate muscle protein synthesis in sepsis despite unimpaired signaling to 4E-BP1 and S6K1 American Journal of Physiology - Endocrinology and Metabolism. 281. PMID 11595662 DOI: 10.1152/Ajpendo.2001.281.5.E1045  0.53
2001 Jefferson LS, Kimball SR. Amino acid regulation of gene expression Journal of Nutrition. 131. PMID 11533294 DOI: 10.1093/Jn/131.9.2460S  0.373
2001 Balage M, Sinaud S, Prod'homme M, Dardevet D, Vary TC, Kimball SR, Jefferson LS, Grizard J. Amino acids and insulin are both required to regulate assembly of the eIF4E. eIF4G complex in rat skeletal muscle. American Journal of Physiology. Endocrinology and Metabolism. 281: E565-74. PMID 11500312 DOI: 10.1152/Ajpendo.2001.281.3.E565  0.532
2001 Anthony TG, Reiter AK, Anthony JC, Kimball SR, Jefferson LS. Deficiency of dietary EAA preferentially inhibits mRNA translation of ribosomal proteins in liver of meal-fed rats. American Journal of Physiology. Endocrinology and Metabolism. 281: E430-9. PMID 11500297 DOI: 10.1152/Ajpendo.2001.281.3.E430  0.824
2001 Kostyak JC, Kimball SR, Jefferson LS, Farrell PA. Severe diabetes inhibits resistance exercise-induced increase in eukaryotic initiation factor 2B activity. Journal of Applied Physiology (Bethesda, Md. : 1985). 91: 79-84. PMID 11408416 DOI: 10.1152/Jappl.2001.91.1.79  0.399
2001 Anthony TG, Anthony JC, Yoshizawa F, Kimball SR, Jefferson LS. Oral administration of leucine stimulates ribosomal protein mRNA translation but not global rates of protein synthesis in the liver of rats. The Journal of Nutrition. 131: 1171-6. PMID 11285321 DOI: 10.1093/Jn/131.4.1171  0.803
2001 Anthony JC, Anthony TG, Kimball SR, Jefferson LS. Signaling pathways involved in translational control of protein synthesis in skeletal muscle by leucine. The Journal of Nutrition. 131: 856S-860S. PMID 11238774 DOI: 10.1093/Jn/131.3.856S  0.82
2001 Kimball SR, Clemens MJ, Tilleray VJ, Wek RC, Horetsky RL, Jefferson LS. The double-stranded RNA-activated protein kinase PKR is dispensable for regulation of translation initiation in response to either calcium mobilization from the endoplasmic reticulum or essential amino acid starvation Biochemical and Biophysical Research Communications. 280: 293-300. PMID 11162513 DOI: 10.1006/Bbrc.2000.4103  0.51
2001 Kimball SR, Jefferson LS. Regulation of protein synthesis by branched-chain amino acids Current Opinion in Clinical Nutrition and Metabolic Care. 4: 39-43. PMID 11122558 DOI: 10.1097/00075197-200101000-00008  0.49
2001 Vary TC, Jefferson LS, Kimball SR. SKELETAL MUSCLE PROTEIN SYNTHESIS IS NOT STIMULATED BY INSULIN DESPITE UNIMPAIRED SIGNALING TO 4E-BP1 AND S6K1 DURING SEPSIS. Shock. 15: 65. DOI: 10.1097/00024382-200106001-00193  0.361
2000 Davis TA, Nguyen HV, Suryawan A, Bush JA, Jefferson LS, Kimball SR. Developmental changes in the feeding-induced stimulation of translation initiation in muscle of neonatal pigs. American Journal of Physiology. Endocrinology and Metabolism. 279: E1226-34. PMID 11093908 DOI: 10.1152/Ajpendo.2000.279.6.E1226  0.481
2000 Shah OJ, Anthony JC, Kimball SR, Jefferson LS. Glucocorticoids oppose translational control by leucine in skeletal muscle. American Journal of Physiology. Endocrinology and Metabolism. 279: E1185-90. PMID 11052975 DOI: 10.1152/Ajpendo.2000.279.5.E1185  0.851
2000 Svanberg E, Frost RA, Lang CH, Isgaard J, Jefferson LS, Kimball SR, Vary TC. IGF-I/IGFBP-3 binary complex modulates sepsis-induced inhibition of protein synthesis in skeletal muscle. American Journal of Physiology. Endocrinology and Metabolism. 279: E1145-58. PMID 11052971 DOI: 10.1152/Ajpendo.2000.279.5.E1145  0.504
2000 Kimball SR, Jefferson LS, Nguyen HV, Suryawan A, Bush JA, Davis TA. Feeding stimulates protein synthesis in muscle and liver of neonatal pigs through an mTOR-dependent process. American Journal of Physiology. Endocrinology and Metabolism. 279: E1080-7. PMID 11052963 DOI: 10.1152/Ajpendo.2000.279.5.E1080  0.532
2000 Hannan KM, Hannan RD, Smith SD, Jefferson LS, Lun M, Rothblum LI. Rb and p130 regulate RNA polymerase I transcription: Rb disrupts the interaction between UBF and SL-1 Oncogene. 19: 4988-4999. PMID 11042686 DOI: 10.1038/Sj.Onc.1203875  0.357
2000 Anthony JC, Yoshizawa F, Anthony TG, Vary TC, Jefferson LS, Kimball SR. Leucine stimulates translation initiation in skeletal muscle of postabsorptive rats via a rapamycin-sensitive pathway. The Journal of Nutrition. 130: 2413-9. PMID 11015466 DOI: 10.1093/Jn/130.10.2413  0.795
2000 Shah OJ, Anthony JC, Kimball SR, Jefferson LS. 4E-BP1 and S6K1: translational integration sites for nutritional and hormonal information in muscle. American Journal of Physiology. Endocrinology and Metabolism. 279: E715-29. PMID 11001751 DOI: 10.1152/Ajpendo.2000.279.4.E715  0.845
2000 Pham PT, Heydrick SJ, Fox HL, Kimball SR, Jefferson LS, Lynch CJ. Assessment of cell-signaling pathways in the regulation of mammalian target of rapamycin (mTOR) by amino acids in rat adipocytes. Journal of Cellular Biochemistry. 79: 427-41. PMID 10972980 DOI: 10.1002/1097-4644(20001201)79:3<427::Aid-Jcb80>3.0.Co;2-0  0.479
2000 Hannan KM, Kennedy BK, Cavanaugh AH, Hannan RD, Hirschler-Laszkiewicz I, Jefferson LS, Rothblum LI. RNA polymerase I transcription in confluent cells: Rb downregulates rDNA transcription during confluence-induced cell cycle arrest Oncogene. 19: 3487-3497. PMID 10918607 DOI: 10.1038/Sj.Onc.1203690  0.326
2000 Shah OJ, Kimball SR, Jefferson LS. Glucocorticoids abate p70(S6k) and eIF4E function in L6 skeletal myoblasts. American Journal of Physiology. Endocrinology and Metabolism. 279: E74-82. PMID 10893325 DOI: 10.1152/Ajpendo.2000.279.1.E74  0.769
2000 Anthony TG, Fabian JR, Kimball SR, Jefferson LS. Identification of domains within the epsilon-subunit of the translation initiation factor eIF2B that are necessary for guanine nucleotide exchange activity and eIF2B holoprotein formation. Biochimica Et Biophysica Acta. 1492: 56-62. PMID 10858531 DOI: 10.1016/S0167-4781(00)00062-2  0.323
2000 Lang CH, Frost RA, Jefferson LS, Kimball SR, Vary TC. Endotoxin-induced decrease in muscle protein synthesis is associated with changes in eIF2B, eIF4E, and IGF-I. American Journal of Physiology. Endocrinology and Metabolism. 278: E1133-43. PMID 10827017 DOI: 10.1152/Ajpendo.2000.278.6.E1133  0.488
2000 Shah OJ, Kimball SR, Jefferson LS. Among translational effectors, p70S6k is uniquely sensitive to inhibition by glucocorticoids. The Biochemical Journal. 347: 389-97. PMID 10749668 DOI: 10.1042/0264-6021:3470389  0.763
2000 Lynch CJ, Fox HL, Vary TC, Jefferson LS, Kimball SR. Regulation of amino acid-sensitive TOR signaling by leucine analogues in adipocytes. Journal of Cellular Biochemistry. 77: 234-51. PMID 10723090 DOI: 10.1002/(Sici)1097-4644(20000501)77:2<234::Aid-Jcb7>3.0.Co;2-I  0.411
2000 Anthony JC, Anthony TG, Kimball SR, Vary TC, Jefferson LS. Orally administered leucine stimulates protein synthesis in skeletal muscle of postabsorptive rats in association with increased eIF4F formation. The Journal of Nutrition. 130: 139-45. PMID 10720160 DOI: 10.1093/Jn/130.2.139  0.773
2000 Farrell PA, Hernandez JM, Fedele MJ, Vary TC, Kimball SR, Jefferson LS. Eukaryotic initiation factors and protein synthesis after resistance exercise in rats. Journal of Applied Physiology (Bethesda, Md. : 1985). 88: 1036-42. PMID 10710401 DOI: 10.1152/Jappl.2000.88.3.1036  0.441
2000 Shah OJ, Kimball SR, Jefferson LS. Acute attenuation of translation initiation and protein synthesis by glucocorticoids in skeletal muscle. American Journal of Physiology. Endocrinology and Metabolism. 278: E76-82. PMID 10644539 DOI: 10.1152/Ajpendo.2000.278.1.E76  0.792
2000 Vary TC, Jefferson LS, Kimball SR. Role of eIF4E in stimulation of protein synthesis by IGF-I in perfused rat skeletal muscle. American Journal of Physiology. Endocrinology and Metabolism. 278: E58-64. PMID 10644537 DOI: 10.1152/Ajpendo.2000.278.1.E58  0.534
2000 Fedele MJ, Hernandez JM, Lang CH, Vary TC, Kimball SR, Jefferson LS, Farrell PA. Severe diabetes prohibits elevations in muscle protein synthesis after acute resistance exercise in rats. Journal of Applied Physiology (Bethesda, Md. : 1985). 88: 102-8. PMID 10642368 DOI: 10.1152/Jappl.2000.88.1.102  0.402
2000 Kimball SR, Jefferson LS. 16 Regulation of Translation Initiation in Mammalian Cells by Amino Acids Cold Spring Harbor Monograph Archive. 39: 561-579. DOI: 10.1101/087969618.39.561  0.46
1999 Vary TC, Jefferson LS, Kimball SR. Amino acid-induced stimulation of translation initiation in rat skeletal muscle American Journal of Physiology - Endocrinology and Metabolism. 277. PMID 10600798 DOI: 10.1152/Ajpendo.1999.277.6.E1077  0.524
1999 Shah OJ, Antonetti DA, Kimball SR, Jefferson LS. Leucine, glutamine, and tyrosine reciprocally modulate the translation initiation factors eIF4F and eIF2B in perfused rat liver. The Journal of Biological Chemistry. 274: 36168-75. PMID 10593901 DOI: 10.1074/Jbc.274.51.36168  0.813
1999 Lang CH, Wu D, Frost RA, Jefferson LS, Vary TC, Kimball SR. Chronic alcohol feeding impairs hepatic translation initiation by modulating eIF2 and eIF4E. The American Journal of Physiology. 277: E805-14. PMID 10567006 DOI: 10.1152/Ajpendo.1999.277.5.E805  0.32
1999 Farrell PA, Fedele MJ, Hernandez J, Fluckey JD, Miller JL, Lang CH, Vary TC, Kimball SR, Jefferson LS. Hypertrophy of skeletal muscle in diabetic rats in response to chronic resistance exercise. Journal of Applied Physiology (Bethesda, Md. : 1985). 87: 1075-82. PMID 10484579 DOI: 10.1152/Jappl.1999.87.3.1075  0.36
1999 Lang CH, Wu D, Frost RA, Jefferson LS, Kimball SR, Vary TC. Inhibition of muscle protein synthesis by alcohol is associated with modulation of eIF2B and eIF4E. The American Journal of Physiology. 277: E268-76. PMID 10444422 DOI: 10.1152/Ajpendo.1999.277.2.E268  0.401
1999 Jefferson LS, Fabian JR, Kimball SR. Glycogen synthase kinase-3 is the predominant insulin-regulated eukaryotic initiation factor 2B kinase in skeletal muscle International Journal of Biochemistry and Cell Biology. 31: 191-200. PMID 10216953 DOI: 10.1016/S1357-2725(98)00141-1  0.496
1999 Kimball SR, Shantz LM, Horetsky RL, Jefferson LS. Leucine regulates translation of specific mRNAs in L6 myoblasts through mTOR-mediated changes in availability of eIF4E and phosphorylation of ribosomal protein S6. The Journal of Biological Chemistry. 274: 11647-52. PMID 10206976 DOI: 10.1074/Jbc.274.17.11647  0.566
1999 Farrell PA, Fedele MJ, Vary TC, Kimball SR, Lang CH, Jefferson LS. Regulation of protein synthesis after acute resistance exercise in diabetic rats. The American Journal of Physiology. 276: E721-7. PMID 10198309 DOI: 10.1152/Ajpendo.1999.276.4.E721  0.411
1999 Sinaud S, Balage M, Bayle G, Dardevet D, Vary TC, Kimball SR, Jefferson LS, Grizard J. Diazoxide-induced insulin deficiency greatly reduced muscle protein synthesis in rats: involvement of eIF4E. The American Journal of Physiology. 276: E50-61. PMID 9886950 DOI: 10.1152/Ajpendo.1999.276.1.E50  0.544
1999 Fedele MJ, Fluckey JD, Hernandez JM, Vary TC, Kimball SR, Jefferson LS, Farrell PA. REDUCED SKELETAL MUSCLE MASS IN MODERATELY DIABETIC RATS IS PARTIALLY RESTORED BY RESISTANCE EXERCISE Medicine & Science in Sports & Exercise. 31: S267. DOI: 10.1097/00005768-199905001-01298  0.347
1998 Yoshizawa F, Kimball SR, Vary TC, Jefferson LS. Effect of dietary protein on translation initiation in rat skeletal muscle and liver. American Journal of Physiology. Endocrinology and Metabolism. 275: E814-E820. PMID 29585217 DOI: 10.1152/ajpendo.1998.275.5.E814  0.376
1998 Kimball SR, Horetsky RL, Jefferson LS. Signal transduction pathways involved in the regulation of protein synthesis by insulin in L6 myoblasts. American Journal of Physiology. Cell Physiology. 274: C221-C228. PMID 29585022 DOI: 10.1152/ajpcell.1998.274.1.C221  0.382
1998 Farrell PA, Fedele MJ, Vary TC, Kimball SR, Jefferson LS. Effects of intensity of acute-resistance exercise on rates of protein synthesis in moderately diabetic rats. Journal of Applied Physiology (Bethesda, Md. : 1985). 85: 2291-7. PMID 9843555 DOI: 10.1152/Jappl.1998.85.6.2291  0.398
1998 Yoshizawa F, Kimball SR, Vary TC, Jefferson LS. Effect of dietary protein on translation initiation in rat skeletal muscle and liver American Journal of Physiology - Endocrinology and Metabolism. 275. PMID 9815001 DOI: 10.1152/Ajpendo.1998.275.5.E814  0.484
1998 Fox HL, Pham PT, Kimball SR, Jefferson LS, Lynch CJ. Amino acid effects on translational repressor 4E-BP1 are mediated primarily by L-leucine in isolated adipocytes. The American Journal of Physiology. 275: C1232-8. PMID 9814971 DOI: 10.1152/Ajpcell.1998.275.5.C1232  0.39
1998 Kimball SR, Horetsky RL, Jefferson LS. Implication of eIF2B rather than eIF4E in the regulation of global protein synthesis by amino acids in L6 myoblasts Journal of Biological Chemistry. 273: 30945-30953. PMID 9812990 DOI: 10.1074/Jbc.273.47.30945  0.53
1998 Hannan KM, Rothblum LI, Jefferson LS. Regulation of ribosomal DNA transcription by insulin American Journal of Physiology - Cell Physiology. 275. PMID 9688843 DOI: 10.1152/Ajpcell.1998.275.1.C130  0.376
1998 Fabian JR, Kimball SR, Jefferson LS. Reconstitution and purification of eukaryotic initiation factor 2B (eIF2B) expressed in Sf21 insect cells Protein Expression and Purification. 13: 16-22. PMID 9631509 DOI: 10.1006/Prep.1998.0860  0.389
1998 Kimball SR, Horetsky RL, Jagus R, Jefferson LS. Expression and purification of the α-subunit of eukaryotic initiation factor eIF2: Use as a kinase substrate Protein Expression and Purification. 12: 415-419. PMID 9535710 DOI: 10.1006/Prep.1998.0863  0.504
1998 Gautsch TA, Anthony JC, Kimball SR, Paul GL, Layman DK, Jefferson LS. Availability of eIF4E regulates skeletal muscle protein synthesis during recovery from exercise. The American Journal of Physiology. 274: C406-14. PMID 9486130 DOI: 10.1152/Ajpcell.1998.274.2.C406  0.776
1998 Kimball SR, Horetsky RL, Jefferson LS. Signal transduction pathways involved in the regulation of protein synthesis by insulin in L6 myoblasts American Journal of Physiology - Cell Physiology. 274. PMID 9458731 DOI: 10.1152/Ajpcell.1998.274.1.C221  0.483
1998 Fox HL, Kimball SR, Jefferson LS, Lynch CJ. Amino acids stimulate phosphorylation of p70(S6k) and organization of rat adipocytes into multicellular clusters American Journal of Physiology - Cell Physiology. 274. PMID 9458729 DOI: 10.1152/Ajpcell.1998.274.1.C206  0.368
1998 Kimball SR, Heinzinger NK, Horetsky RL, Jefferson LS. Identification of interprotein interactions between the subunits of eukaryotic initiation factors eIF2 and eIF2B. The Journal of Biological Chemistry. 273: 3039-44. PMID 9446619 DOI: 10.1074/Jbc.273.5.3039  0.448
1998 Vary TC, Eckman RA, Kimball SR, Jefferson LS. REGULATION OF SKELETAL MUSCLE PROTEIN SYNTHESIS BY EUKARYOTIC INITIATION FACTORS IN RESPONSE TO AMINO ACIDS. Shock. 9: 9-10. DOI: 10.1097/00024382-199806001-00031  0.347
1998 Farrell PA, Fedele M, Vary TC, Kimball SR, Jefferson LS. EFFECT OF DIABETES ON RATES OF PROTEIN SYNTHESIS IN SKELETAL MUSCLE AFTER RESISTANCE EXERCISE IN RATS Medicine & Science in Sports & Exercise. 30: 23. DOI: 10.1097/00005768-199805001-00131  0.426
1997 Yoshizawa F, Kimball SR, Jefferson LS. Modulation of translation initiation in rat skeletal muscle and liver in response to food intake Biochemical and Biophysical Research Communications. 240: 825-831. PMID 9398653 DOI: 10.1006/Bbrc.1997.7652  0.525
1997 Svanberg E, Jefferson LS, Lundholm K, Kimball SR. Postprandial stimulation of muscle protein synthesis is independent of changes in insulin. The American Journal of Physiology. 272: E841-7. PMID 9176184 DOI: 10.1152/Ajpendo.1997.272.5.E841  0.352
1997 Fabian JR, Kimball SR, Heinzinger NK, Jefferson LS. Subunit assembly and guanine nucleotide exchange activity of eukaryotic initiation factor-2B expressed in Sf9 cells. The Journal of Biological Chemistry. 272: 12359-65. PMID 9139680 DOI: 10.1074/Jbc.272.19.12359  0.368
1997 Kimball SR, Jurasinski CV, Lawrence JC, Jefferson LS. Insulin stimulates protein synthesis in skeletal muscle by enhancing the association of eIF-4E and eIF-4G. The American Journal of Physiology. 272: C754-9. PMID 9124320 DOI: 10.1152/AJPCELL.1997.272.2.C754  0.398
1996 Price NT, Mellor H, Craddock BL, Flowers KM, Kimball SR, Wilmer T, Jefferson LS, Proud CG. eIF2B, the guanine nucleotide-exchange factor for eukaryotic initiation factor 2. Sequence conservation between the alpha, beta and delta subunits of eIF2B from mammals and yeast. The Biochemical Journal. 318: 637-43. PMID 8929216 DOI: 10.1042/Bj3180637  0.346
1996 Kimball SR, Yancisin M, Horetsky RL, Jefferson LS. Translational and pretranslational regulation of protein synthesis by amino acid availability in primary cultures of rat hepatocytes International Journal of Biochemistry and Cell Biology. 28: 285-294. PMID 8920637 DOI: 10.1016/1357-2725(95)00143-3  0.467
1996 Price NT, Kimball SR, Jefferson LS, Proud CG. Cloning of cDNA for the gamma-subunit of mammalian translation initiation factor 2B, the guanine nucleotide-exchange factor for eukaryotic initiation factor 2. The Biochemical Journal. 631-6. PMID 8809057 DOI: 10.1042/Bj3180631  0.37
1996 Fluckey JD, Vary TC, Jefferson LS, Evans WJ, Farrell PA. Insulin stimulation of protein synthesis in rat skeletal muscle following resistance exercise is maintained with advancing age Journals of Gerontology - Series a Biological Sciences and Medical Sciences. 51. PMID 8808980 DOI: 10.1093/Gerona/51A.5.B323  0.423
1996 Fluckey JD, Vary TC, Jefferson LS, Farrell PA. Augmented insulin action on rates of protein synthesis after resistance exercise in rats American Journal of Physiology - Endocrinology and Metabolism. 270. PMID 8779954 DOI: 10.1152/Ajpendo.1996.270.2.E313  0.446
1996 Kimball SR, Jefferson LS, Fadden P, Haystead TAJ, Lawrence JC. Insulin and diabetes cause reciprocal changes in the association of eIF-4E and PHAS-I in rat skeletal muscle American Journal of Physiology - Cell Physiology. 270. PMID 8779938 DOI: 10.1152/Ajpcell.1996.270.2.C705  0.328
1996 Voisin L, Gray K, Flowers KM, Kimball SR, Jefferson LS, Vary TC. Altered expression of eukaryotic initiation factor 2B in skeletal muscle during sepsis. The American Journal of Physiology. 270: E43-50. PMID 8772472 DOI: 10.1152/Ajpendo.1996.270.1.E43  0.431
1996 Kimball SR, Mellor H, Flowers KM, Jefferson LS. Role of translation initiation factor eIF-2B in the regulation of protein synthesis in mammalian cells. Progress in Nucleic Acid Research and Molecular Biology. 54: 165-96. PMID 8768075 DOI: 10.1016/S0079-6603(08)60363-3  0.453
1996 Flowers KM, Mellor H, Matts RL, Kimball SR, Jefferson LS. Cloning and characterization of complementary and genomic DNAs encoding the epsilon-subunit of rat translation initiation factor-2B. Biochimica Et Biophysica Acta. 1307: 318-24. PMID 8688467 DOI: 10.1016/0167-4781(96)00055-3  0.424
1995 Kimball SR, Chen SJ, Risica R, Jefferson LS, Leure-duPree AE. Effects of zinc deficiency on protein synthesis and expression of specific mRNAs in rat liver. Metabolism: Clinical and Experimental. 44: 126-33. PMID 7854157 DOI: 10.1016/0026-0495(95)90299-6  0.503
1995 Kimball SR, Horetsky RL, Jefferson LS. Hormonal regulation of albumin gene expression in primary cultures of rat hepatocytes American Journal of Physiology - Endocrinology and Metabolism. 268. PMID 7840183 DOI: 10.1152/Ajpendo.1995.268.1.E6  0.415
1995 Flowers KM, Kimball SR, Feldhoff RC, Hinnebusch AG, Jefferson LS. Molecular cloning and characterization of cDNA encoding the α subunit of the rat protein synthesis initiation factor eIF-2B Proceedings of the National Academy of Sciences of the United States of America. 92: 4274-4278. PMID 7753796 DOI: 10.1073/Pnas.92.10.4274  0.371
1995 Kimball SR, Jefferson LS. Allosteric regulation of eukaryotic initiation factor eIF-2B by adenine nucleotides Biochemical and Biophysical Research Communications. 212: 1074-1081. PMID 7626095 DOI: 10.1006/Bbrc.1995.2079  0.334
1995 Flowers KM, Mellor H, Kimball SR, Jefferson LS. Structure and sequence of the gene encoding the alpha-subunit of rat translation initiation factor-2B. Biochimica Et Biophysica Acta. 1264: 163-7. PMID 7495858 DOI: 10.1016/0167-4781(95)00160-I  0.348
1994 Dahn MS, Hsu CJ, Lange MP, Jefferson LS. Effects of tumor necrosis factor-alpha on glucose and albumin production in primary cultures of rat hepatocytes. Metabolism: Clinical and Experimental. 43: 476-80. PMID 8159107 DOI: 10.1016/0026-0495(94)90080-9  0.303
1994 Mellor H, Kimball SR, Jefferson LS. Brefeldin A inhibits protein synthesis through the phosphorylation of the α-subunit of eukaryotic initiation factor-2 Febs Letters. 350: 143-146. PMID 8062914 DOI: 10.1016/0014-5793(94)00756-X  0.468
1994 Kimball SR, Vary TC, Jefferson LS. Regulation of protein synthesis by insulin Annual Review of Physiology. 56: 321-348. PMID 8010743 DOI: 10.1146/Annurev.Ph.56.030194.001541  0.446
1994 Mellor H, Flowers KM, Kimball SR, Jefferson LS. Cloning and characterization of a cDNA encoding rat PKR, the double-stranded RNA-dependent eukaryotic initiation factor-2 kinase. Biochimica Et Biophysica Acta. 1219: 693-6. PMID 7948027 DOI: 10.1016/0167-4781(94)90229-1  0.401
1994 Kimball SR, Jefferson LS. Mechanisms of translational control in liver and skeletal muscle Biochimie. 76: 729-736. PMID 7893823 DOI: 10.1016/0300-9084(94)90077-9  0.526
1994 Kimball SR, Karinch AM, Feldhoff RC, Mellor H, Jefferson LS. Purification and characterization of eukaryotic translational initiation factor eIF-2B from liver. Biochimica Et Biophysica Acta. 1201: 473-81. PMID 7803480 DOI: 10.1016/0304-4165(94)90079-5  0.312
1993 Dahn MS, Hsu CJ, Lange MP, Kimball SR, Jefferson LS. Factors affecting secretory protein production in primary cultures of rat hepatocytes. Proceedings of the Society For Experimental Biology and Medicine. Society For Experimental Biology and Medicine (New York, N.Y.). 203: 38-44. PMID 8475137 DOI: 10.3181/00379727-203-43570  0.394
1993 Ojamaa KM, Kimball SR, Jefferson LS. Aminoacylation of initiator methionyl-tRNA(i) under conditions inhibitory to initiation of protein synthesis American Journal of Physiology - Endocrinology and Metabolism. 264. PMID 8447393 DOI: 10.1152/Ajpendo.1993.264.2.E257  0.346
1993 Karinch AM, Kimball SR, Vary TC, Jefferson LS. Regulation of eukaryotic initiation factor-2B activity in muscle of diabetic rats. The American Journal of Physiology. 264: E101-8. PMID 8430778 DOI: 10.1152/Ajpendo.1993.264.1.E101  0.429
1993 Feldhoff R, Karinch AM, Kimball S, Jefferson L. Purification of eukaryotic initiation factors elf-2, elf-2b and elfb1; kinase from bovine liver Preparative Biochemistry. 23: 363-374. PMID 8103216 DOI: 10.1080/10826069308544562  0.336
1992 Kimball SR, Vary TC, Jefferson LS. Age-dependent decrease in the amount of eukaryotic initiation factor 2 in various rat tissues Biochemical Journal. 286: 263-268. PMID 1381583 DOI: 10.1042/Bj2860263  0.473
1992 Kimball SR, Jefferson LS. Regulation of protein synthesis by modulation of intracellular calcium in rat liver American Journal of Physiology - Endocrinology and Metabolism. 263. PMID 1359794 DOI: 10.1152/Ajpendo.1992.263.5.E958  0.441
1992 Hsu CJ, Kimball SR, Antonetti DA, Jefferson LS. Effects of insulin on total RNA, poly(A)+ RNA, and mRNA in primary cultures of rat hepatocytes American Journal of Physiology - Endocrinology and Metabolism. 263. PMID 1282301 DOI: 10.1152/Ajpendo.1992.263.6.E1106  0.675
1992 Hsu CJ, Kimball SR, Antonetti DA, Jefferson LS. Effects of insulin on total RNA, poly(A)+ RNA, and mRNA in primary cultures of rat hepatocytes American Journal of Physiology-Endocrinology and Metabolism. 263: E1106-E1112. DOI: 10.1152/AJPENDO.1992.263.6.E1106  0.335
1991 Kimball SR, Jefferson LS. Inhibition of microsomal calcium sequestration causes an impairment of initiation of protein synthesis in perfused rat liver Biochemical and Biophysical Research Communications. 177: 1082-1086. PMID 2059198 DOI: 10.1016/0006-291X(91)90649-R  0.327
1991 Kimball SR, Jefferson LS. Regulation of initiation of protein synthesis by insulin in skeletal muscle Acta Diabetologica. 28: 134-139. PMID 1777648 DOI: 10.1007/Bf00579715  0.492
1991 Kent JD, Kimball SR, Jefferson LS. Effect of diabetes and insulin treatment of diabetic rats on total RNA, poly(A)+ RNA, and mRNA in skeletal muscle American Journal of Physiology - Cell Physiology. 260. PMID 1706142 DOI: 10.1152/Ajpcell.1991.260.3.C409  0.373
1989 Everson WV, Flaim KE, Susco DM, Kimball SR, Jefferson LS. Effect of amino acid deprivation on initiation of protein synthesis in rat hepatocytes. The American Journal of Physiology. 256: C18-27. PMID 2492151 DOI: 10.1152/AJPCELL.1989.256.1.C18  0.346
1989 Kimball SR, Everson WV, Flaim KE, Jefferson LS. Initiation of protein synthesis in a cell-free system prepared from rat hepatocytes. The American Journal of Physiology. 256: C28-34. PMID 2463762 DOI: 10.1152/AJPCELL.1989.256.1.C28  0.342
1988 Lewandowski AE, Liao WS, Stinson-Fisher CA, Kent JD, Jefferson LS. Effects of experimentally induced nephrosis on protein synthesis in rat liver. The American Journal of Physiology. 254: C634-42. PMID 3364551 DOI: 10.1152/Ajpcell.1988.254.5.C634  0.486
1988 Kimball SR, Rannels SL, Elensky MB, Jefferson LS. Quantitation of proteins by dot-immunobinding assay A comparison of visualization methods using eukaryotic initiation factor 2 and a monospecific antibody Journal of Immunological Methods. 106: 217-223. PMID 3276793 DOI: 10.1016/0022-1759(88)90200-1  0.313
1988 Kimball SR, Jefferson LS. Cellular mechanisms involved in the action of insulin on protein synthesis Diabetes/Metabolism Reviews. 4: 773-787. PMID 3069402 DOI: 10.1002/Dmr.5610040806  0.408
1987 Hutson SM, Stinson-Fisher C, Shiman R, Jefferson LS. Regulation of albumin synthesis by hormones and amino acids in primary cultures of rat hepatocytes American Journal of Physiology - Endocrinology and Metabolism. 252. PMID 3548426 DOI: 10.1152/Ajpendo.1987.252.3.E291  0.366
1987 Lloyd CE, Kalinyak JE, Hutson SM, Jefferson LS. Stimulation of albumin gene transcription by insulin in primary cultures of rat hepatocytes American Journal of Physiology - Cell Physiology. 252. PMID 3548414 DOI: 10.1152/Ajpcell.1987.252.2.C205  0.394
1986 Liao WS, Jefferson LS, Taylor JM. Changes in plasma albumin concentration, synthesis rate, and mRNA level during acute inflammation. The American Journal of Physiology. 251: C928-34. PMID 3789133 DOI: 10.1152/Ajpcell.1986.251.6.C928  0.395
1985 Elshourbagy NA, Boguski MS, Liao WS, Jefferson LS, Gordon JI, Taylor JM. Expression of rat apolipoprotein A-IV and A-I genes: mRNA induction during development and in response to glucocorticoids and insulin. Proceedings of the National Academy of Sciences of the United States of America. 82: 8242-6. PMID 3934672 DOI: 10.1073/Pnas.82.23.8242  0.429
1984 Bylund-Fellenius AC, Ojamaa KM, Flaim KE, Li JB, Wassner SJ, Jefferson LS. Protein synthesis versus energy state in contracting muscles of perfused rat hindlimb. The American Journal of Physiology. 246: E297-305. PMID 6720885 DOI: 10.1152/Ajpendo.1984.246.4.E297  0.456
1984 Foulkes JG, Jefferson LS. Protein phosphatase-1 and -2A activities in heart, liver, and skeletal muscle extracts from control and diabetic rats Diabetes. 33: 576-579. PMID 6327437 DOI: 10.2337/diab.33.6.576  0.353
1982 Abumrad NN, Jefferson LS, Rannels SR, Williams PE, Cherrington AD, Lacy WW. Role of insulin in the regulation of leucine kinetics in the conscious dog. The Journal of Clinical Investigation. 70: 1031-41. PMID 6127347 DOI: 10.1172/Jci110690  0.32
1982 Rannels D, Flaim K, Jefferson L. HALOTHANE INHIBITS SYNTHESIS OF RETAINED AND SECRETED PROTEINS IN PERFUSED RAT LIVER Anesthesiology. 57: A231-A231. DOI: 10.1097/00000542-198209001-00231  0.304
1981 Peavy DE, Taylor JM, Jefferson LS. Protein synthesis in perfused rat liver following thyroidectomy and hormone treatment The American Journal of Physiology. 240. PMID 7457595 DOI: 10.1152/Ajpendo.1981.240.1.E18  0.456
1981 Peavy DE, Taylor JM, Jefferson LS. Alterations in albumin secretion and total protein synthesis in livers of thyroidectomized rats. The Biochemical Journal. 198: 289-99. PMID 7326007 DOI: 10.1042/Bj1980289  0.502
1980 Jefferson LS. Role of insulin in the regulation of protein synthesis Diabetes. 29: 487-496. PMID 6991336 DOI: 10.2337/Diab.29.6.487  0.507
1980 Klingensmith MR, Freifeld AG, Pegg AE, Jefferson LS. Effects of growth hormone and glucagon on ornithine decarboxylase activity and adenosine 3',5'-monophosphate levels in isolated rat hepatocytes. Endocrinology. 106: 125-32. PMID 6243092 DOI: 10.1210/Endo-106-1-125  0.329
1980 Jefferson LS, Boyd TA, Flaim KE, Peavy DE. Regulation of protein synthesis in perfused preparations of rat heart, skeletal muscle and liver Biochemical Society Transactions. 8: 282-283. PMID 6156866 DOI: 10.1042/Bst0080282  0.453
1978 Li JB, Jefferson LS. Influence of amino acid availability on protein turnover in perfused skeletal muscle Bba - General Subjects. 544: 351-359. PMID 719005 DOI: 10.1016/0304-4165(78)90103-4  0.414
1978 Flaim KE, Li JB, Jefferson LS. Effects of thyroxine on protein turnover in rat skeletal muscle. The American Journal of Physiology. 235: E231-6. PMID 686169 DOI: 10.1152/AJPENDO.1978.235.2.E231  0.367
1978 Rannels DE, Pegg AE, Rannels SR, Jefferson LS. Effect of starvation on initiation of protein synthesis in skeletal muscle and heart. The American Journal of Physiology. 235: E126-33. PMID 686162 DOI: 10.1152/Ajpendo.1978.235.2.E126  0.3
1978 Flaim KE, Li JB, Jefferson LS. Protein turnover in rat skeletal muscle: effects of hypophysectomy and growth hormone. The American Journal of Physiology. 234: E38-43. PMID 623246 DOI: 10.1152/AJPENDO.1978.234.1.E38  0.391
1978 Peavy DE, Taylor JM, Jefferson LS. Correlation of albumin production rates and albumin mRNA levels in livers of normal, diabetic, and insulin-treated diabetic rats Proceedings of the National Academy of Sciences of the United States of America. 75: 5879-5883. PMID 282608 DOI: 10.1073/Pnas.75.12.5879  0.431
1972 Jefferson LS, Koehler JO, Morgan HE. Effect of insulin on protein synthesis in skeletal muscle of an isolated perfused preparation of rat hemicorpus Proceedings of the National Academy of Sciences of the United States of America. 69: 816-820. PMID 4502934 DOI: 10.1073/pnas.69.4.816  0.336
1966 Exton JH, Jefferson LS, Butcher RW, Park CR. Gluconeogenesis in the perfused liver. The effects of fasting, alloxan diabetes, glucagon, epinephrine, adenosine 3',5'-monophosphate and insulin. The American Journal of Medicine. 40: 709-15. PMID 5941966 DOI: 10.1016/0002-9343(66)90151-3  0.305
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