Sean Egan - Publications

University of Toronto, Toronto, ON, Canada 
Molecular Biology, Cell Biology

41 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2018 An Y, Adams JR, Hollern DP, Zhao A, Chang SG, Gams MS, Chung PED, He X, Jangra R, Shah JS, Yang J, Beck LA, Raghuram N, Kozma KJ, Loch AJ, ... ... Egan SE, et al. Cdh1 and Pik3ca Mutations Cooperate to Induce Immune-Related Invasive Lobular Carcinoma of the Breast. Cell Reports. 25: 702-714.e6. PMID 30332649 DOI: 10.1016/j.celrep.2018.09.056  0.36
2018 Liu JC, Granieri L, Shrestha M, Wang DY, Vorobieva I, Rubie EA, Jones R, Ju Y, Pellecchia G, Jiang Z, Palmerini CA, Ben-David Y, Egan SE, Woodgett JR, Bader GD, et al. Identification of CDC25 as a Common Therapeutic Target for Triple-Negative Breast Cancer. Cell Reports. 23: 112-126. PMID 29617654 DOI: 10.1016/j.celrep.2018.03.039  0.36
2016 Jones RA, Robinson TJ, Liu JC, Shrestha M, Voisin V, Ju Y, Chung PE, Pellecchia G, Fell VL, Bae S, Muthuswamy L, Datti A, Egan SE, Jiang Z, Leone G, et al. RB1 deficiency in triple-negative breast cancer induces mitochondrial protein translation. The Journal of Clinical Investigation. PMID 27571409 DOI: 10.1172/JCI81568  0.84
2016 Liu JC, Wang DY, Egan SE, Zacksenhaus E. Common and distinct features of mammary tumors driven by Pten-deletion or activating Pik3ca mutation. Oncotarget. PMID 26814435 DOI: 10.18632/oncotarget.6985  0.84
2015 Wright KL, Adams JR, Liu JC, Loch AJ, Wong RG, Jo CE, Beck LA, Santhanam DR, Weiss L, Mei X, Lane TF, Koralov SB, Done SJ, Woodgett JR, Zacksenhaus E, ... ... Egan SE, et al. Ras signaling is a key determinant of metastatic dissemination and poor survival of luminal breast cancer patients. Cancer Research. PMID 26400062 DOI: 10.1158/0008-5472.CAN-14-2992  0.84
2015 Zhang S, Chung WC, Wu G, Egan SE, Miele L, Xu K. Manic fringe promotes a claudin-low breast cancer phenotype through notch-mediated PIK3CG induction. Cancer Research. 75: 1936-43. PMID 25808869 DOI: 10.1158/0008-5472.CAN-14-3303  0.84
2014 Jiang Z, Liu JC, Chung PE, Egan SE, Zacksenhaus E. Targeting HER2(+) breast cancer: the TBK1/IKKε axis. Oncoscience. 1: 180-2. PMID 25594009  0.36
2014 Jiang K, Wright KL, Zhu P, Szego MJ, Bramall AN, Hauswirth WW, Li Q, Egan SE, McInnes RR. STAT3 promotes survival of mutant photoreceptors in inherited photoreceptor degeneration models. Proceedings of the National Academy of Sciences of the United States of America. 111: E5716-23. PMID 25512545 DOI: 10.1073/pnas.1411248112  0.84
2014 Liu JC, Voisin V, Wang S, Wang DY, Jones RA, Datti A, Uehling D, Al-awar R, Egan SE, Bader GD, Tsao M, Mak TW, Zacksenhaus E. Combined deletion of Pten and p53 in mammary epithelium accelerates triple-negative breast cancer with dependency on eEF2K. Embo Molecular Medicine. 6: 1542-60. PMID 25330770 DOI: 10.15252/emmm.201404402  0.84
2014 Wu AM, Yang M, Dalvi P, Turinsky AL, Wang W, Butcher D, Egan SE, Weksberg R, Harper PA, Ito S. Role of STAT5 and epigenetics in lactation-associated upregulation of multidrug transporter ABCG2 in the mammary gland. American Journal of Physiology. Endocrinology and Metabolism. 307: E596-610. PMID 25117410 DOI: 10.1152/ajpendo.00323.2014  0.84
2014 Zhang S, Chung WC, Wu G, Egan SE, Xu K. Tumor-suppressive activity of Lunatic Fringe in prostate through differential modulation of Notch receptor activation. Neoplasia (New York, N.Y.). 16: 158-67. PMID 24709423 DOI: 10.1593/neo.131870  0.84
2014 Deng T, Liu JC, Chung PE, Uehling D, Aman A, Joseph B, Ketela T, Jiang Z, Schachter NF, Rottapel R, Egan SE, Al-Awar R, Moffat J, Zacksenhaus E. shRNA kinome screen identifies TBK1 as a therapeutic target for HER2+ breast cancer. Cancer Research. 74: 2119-30. PMID 24487029 DOI: 10.1158/0008-5472.CAN-13-2138  0.84
2013 Robinson TJ, Liu JC, Vizeacoumar F, Sun T, Maclean N, Egan SE, Schimmer AD, Datti A, Zacksenhaus E. RB1 status in triple negative breast cancer cells dictates response to radiation treatment and selective therapeutic drugs. Plos One. 8: e78641. PMID 24265703 DOI: 10.1371/journal.pone.0078641  0.84
2013 Pfefferle AD, Herschkowitz JI, Usary J, Harrell JC, Spike BT, Adams JR, Torres-Arzayus MI, Brown M, Egan SE, Wahl GM, Rosen JM, Perou CM. Transcriptomic classification of genetically engineered mouse models of breast cancer identifies human subtype counterparts. Genome Biology. 14: R125. PMID 24220145 DOI: 10.1186/gb-2013-14-11-r125  0.84
2013 Robinson TJ, Pai M, Liu JC, Vizeacoumar F, Sun T, Egan SE, Datti A, Huang J, Zacksenhaus E. High-throughput screen identifies disulfiram as a potential therapeutic for triple-negative breast cancer cells: interaction with IQ motif-containing factors. Cell Cycle (Georgetown, Tex.). 12: 3013-24. PMID 23974104 DOI: 10.4161/cc.26063  0.84
2013 Liu JC, Egan SE, Zacksenhaus E. A Tumor initiating cell-enriched prognostic signature for HER2+:ERα- breast cancer; rationale, new features, controversies and future directions. Oncotarget. 4: 1317-28. PMID 23945331 DOI: 10.18632/oncotarget.1170  0.84
2013 Sargin D, Botly LC, Higgs G, Marsolais A, Frankland PW, Egan SE, Josselyn SA. Reprint of: disrupting Jagged1-Notch signaling impairs spatial memory formation in adult mice. Neurobiology of Learning and Memory. 105: 20-30. PMID 23850596 DOI: 10.1016/j.nlm.2013.07.001  0.84
2013 Sargin D, Botly LC, Higgs G, Marsolais A, Frankland PW, Egan SE, Josselyn SA. Disrupting Jagged1-Notch signaling impairs spatial memory formation in adult mice. Neurobiology of Learning and Memory. 103: 39-49. PMID 23567106 DOI: 10.1016/j.nlm.2013.03.001  0.84
2013 Zhang S, Loch AJ, Radtke F, Egan SE, Xu K. Jagged1 is the major regulator of notch-dependent cell fate in proximal airways Developmental Dynamics. 242: 678-686. PMID 23526493 DOI: 10.1002/dvdy.23965  0.84
2013 Sengar AS, Ellegood J, Yiu AP, Wang H, Wang W, Juneja SC, Lerch JP, Josselyn SA, Henkelman RM, Salter MW, Egan SE. Vertebrate intersectin1 is repurposed to facilitate cortical midline connectivity and higher order cognition. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 4055-65. PMID 23447614 DOI: 10.1523/JNEUROSCI.4428-12.2013  0.84
2012 Xu K, Usary J, Kousis PC, Prat A, Wang DY, Adams JR, Wang W, Loch AJ, Deng T, Zhao W, Cardiff RD, Yoon K, Gaiano N, Ling V, Beyene J, ... ... Egan SE, et al. Lunatic fringe deficiency cooperates with the Met/Caveolin gene amplicon to induce basal-like breast cancer. Cancer Cell. 21: 626-41. PMID 22624713 DOI: 10.1016/j.ccr.2012.03.041  0.84
2012 Liu JC, Voisin V, Bader GD, Deng T, Pusztai L, Symmans WF, Esteva FJ, Egan SE, Zacksenhaus E. Seventeen-gene signature from enriched Her2/Neu mammary tumor-initiating cells predicts clinical outcome for human HER2+:ERα- breast cancer. Proceedings of the National Academy of Sciences of the United States of America. 109: 5832-7. PMID 22460789 DOI: 10.1073/pnas.1201105109  0.84
2012 Li Y, Vecchiarelli-Federico LM, Li YJ, Egan SE, Spaner D, Hough MR, Ben-David Y. The miR-17-92 cluster expands multipotent hematopoietic progenitors whereas imbalanced expression of its individual oncogenic miRNAs promotes leukemia in mice. Blood. 119: 4486-98. PMID 22451425 DOI: 10.1182/blood-2011-09-378687  0.84
2012 Xu K, Moghal N, Egan SE. Notch signaling in lung development and disease. Advances in Experimental Medicine and Biology. 727: 89-98. PMID 22399341 DOI: 10.1007/978-1-4614-0899-4_7  0.84
2012 Waters AM, Wu MY, Huang YW, Liu GY, Holmyard D, Onay T, Jones N, Egan SE, Robinson LA, Piscione TD. Notch promotes dynamin-dependent endocytosis of nephrin. Journal of the American Society of Nephrology : Jasn. 23: 27-35. PMID 22052054 DOI: 10.1681/ASN.2011010027  0.84
2011 Suliman S, Tan J, Xu K, Kousis PC, Kowalski PE, Chang G, Egan SE, Guidos C. Notch3 is dispensable for thymocyte β-selection and Notch1-induced T cell leukemogenesis. Plos One. 6: e24937. PMID 21931869 DOI: 10.1371/journal.pone.0024937  0.84
2011 Adams JR, Schachter NF, Liu JC, Zacksenhaus E, Egan SE. Elevated PI3K signaling drives multiple breast cancer subtypes Oncotarget. 2: 435-447. PMID 21646685  0.84
2011 Raafat A, Goldhar AS, Klauzinska M, Xu K, Amirjazil I, McCurdy D, Lashin K, Salomon D, Vonderhaar BK, Egan S, Callahan R. Expression of Notch receptors, ligands, and target genes during development of the mouse mammary gland. Journal of Cellular Physiology. 226: 1940-52. PMID 21506125 DOI: 10.1002/jcp.22526  0.84
2011 Jiang Z, Jones R, Liu JC, Deng T, Robinson T, Chung PE, Wang S, Herschkowitz JI, Egan SE, Perou CM, Zacksenhaus E. RB1 and p53 at the crossroad of EMT and triple-negative breast cancer. Cell Cycle (Georgetown, Tex.). 10: 1563-70. PMID 21502814 DOI: 10.4161/cc.10.10.15703  0.84
2011 Adams JR, Xu K, Liu JC, Agamez NM, Loch AJ, Wong RG, Wang W, Wright KL, Lane TF, Zacksenhaus E, Egan SE. Cooperation between Pik3ca and p53 mutations in mouse mammary tumor formation. Cancer Research. 71: 2706-17. PMID 21324922 DOI: 10.1158/0008-5472.CAN-10-0738  0.84
2011 Yuan JS, Tan JB, Visan I, Matei IR, Urbanellis P, Xu K, Danska JS, Egan SE, Guidos CJ. Lunatic Fringe prolongs Delta/Notch-induced self-renewal of committed αβ T-cell progenitors. Blood. 117: 1184-95. PMID 21097675 DOI: 10.1182/blood-2010-07-296616  0.84
2010 Xu K, Nieuwenhuis E, Cohen BL, Wang W, Canty AJ, Danska JS, Coultas L, Rossant J, Wu MY, Piscione TD, Nagy A, Gossler A, Hicks GG, Hui CC, Henkelman RM, ... ... Egan SE, et al. Lunatic Fringe-mediated Notch signaling is required for lung alveogenesis. American Journal of Physiology. Lung Cellular and Molecular Physiology. 298: L45-56. PMID 19897741 DOI: 10.1152/ajplung.90550.2008  0.84
2008 Wang W, Bouhours M, Gracheva EO, Liao EH, Xu K, Sengar AS, Xin X, Roder J, Boone C, Richmond JE, Zhen M, Egan SE. ITSN-1 controls vesicle recycling at the neuromuscular junction and functions in parallel with DAB-1. Traffic (Copenhagen, Denmark). 9: 742-54. PMID 18298590 DOI: 10.1111/j.1600-0854.2008.00712.x  0.84
2008 Jiang X, Tian F, Du Y, Copeland NG, Jenkins NA, Tessarollo L, Wu X, Pan H, Hu XZ, Xu K, Kenney H, Egan SE, Turley H, Harris AL, Marini AM, et al. BHLHB2 controls Bdnf promoter 4 activity and neuronal excitability. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 1118-30. PMID 18234890 DOI: 10.1523/JNEUROSCI.2262-07.2008  0.84
2004 St-Pierre B, Jiang Z, Egan SE, Zacksenhaus E. High expression during neurogenesis but not mammogenesis of a murine homologue of the Deleted in Breast Cancer2/Rhobtb2 tumor suppressor. Gene Expression Patterns : Gep. 5: 245-51. PMID 15567721 DOI: 10.1016/j.modgep.2004.07.009  0.84
2004 Callahan R, Egan SE. Notch signaling in mammary development and oncogenesis. Journal of Mammary Gland Biology and Neoplasia. 9: 145-63. PMID 15300010 DOI: 10.1023/B:JOMG.0000037159.63644.81  0.84
2004 Hughes M, Dobric N, Scott IC, Su L, Starovic M, St-Pierre B, Egan SE, Kingdom JC, Cross JC. The Hand1, Stra13 and Gcm1 transcription factors override FGF signaling to promote terminal differentiation of trophoblast stem cells. Developmental Biology. 271: 26-37. PMID 15196947 DOI: 10.1016/j.ydbio.2004.03.029  0.84
2004 St-Pierre B, Cooper M, Jiang Z, Zacksenhaus E, Egan SE. Dynamic regulation of the Stra13/Sharp/Dec bHLH repressors in mammary epithelium. Developmental Dynamics : An Official Publication of the American Association of Anatomists. 230: 124-30. PMID 15108316 DOI: 10.1002/dvdy.20013  0.84
2002 St-Pierre B, Flock G, Zacksenhaus E, Egan SE. Stra13 homodimers repress transcription through class B E-box elements. The Journal of Biological Chemistry. 277: 46544-51. PMID 12297495 DOI: 10.1074/jbc.M111652200  0.84
1998 Egan SE, St-Pierre B, Leow CC. Notch receptors, partners and regulators: from conserved domains to powerful functions. Current Topics in Microbiology and Immunology. 228: 273-324. PMID 9401210  0.84
1997 Cohen B, Bashirullah A, Dagnino L, Campbell C, Fisher WW, Leow CC, Whiting E, Ryan D, Zinyk D, Boulianne G, Hui CC, Gallie B, Phillips RA, Lipshitz HD, Egan SE. Fringe boundaries coincide with Notch-dependent patterning centres in mammals and alter Notch-dependent development in Drosophila. Nature Genetics. 16: 283-8. PMID 9207795 DOI: 10.1038/ng0797-283  0.84
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