Keith Humphries - Publications

Affiliations: 
University of British Columbia, Vancouver, Vancouver, BC, Canada 
Area:
Genetics, Cell Biology

27 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Barbosa K, Deshpande A, Perales ME, Xiang P, Murad R, Pramod AB, Minkina A, Robertson NA, Schischlik F, Lei X, Sun Y, Brown A, Amend D, Jeremias I, Doench JG, ... Humphries KK, et al. TRANSCRIPTIONAL CONTROL OF LEUKEMOGENESIS BY THE CHROMATIN READER SGF29. Blood. PMID 38048593 DOI: 10.1182/blood.2023021234  0.442
2019 Sun AC, Kusakabe M, Tyshchenko K, Wei K, Kyroglou E, Huynh T, Gutierrez G, Nanda A, Gusscott S, Humphries K, Hirst M, Eaves C, Weng A. 3169 – ONCOGENE CONTRIBUTIONS IN A SYNTHETIC MODEL OF DE NOVO GENERATED HUMAN T-CELL ACUTE LYMPHOBLASTIC LEUKEMIA Experimental Hematology. 76: e3. DOI: 10.1016/J.Exphem.2019.09.011  0.362
2019 Coulombe P, Xiang P, Parker J, Humphries K, Karsan A. MEIS1 EXPRESSION IN MOUSE EMBRYONIC HEMATOPOIESIS Experimental Hematology. 76: S62. DOI: 10.1016/J.Exphem.2019.06.344  0.462
2017 Gasparetto M, Pei S, Minhajuddin M, Khan N, Pollyea DA, Myers JR, Ashton JM, Becker MW, Vasiliou V, Humphries KR, Jordan CT, Smith CA. Targeted therapy for a subset of acute myeloid leukemias that lack expression of aldehyde dehydrogenase 1A1. Haematologica. PMID 28280079 DOI: 10.3324/Haematol.2016.159053  0.389
2017 Zhao HF, Abraham A, Kim YS, Wang YD, Pestina T, Zhan J, Humphries K, Nienhuis AW, Persons DA. Lentiviral Transfer of γ-Globin with Fusion Gene NUP98-HOXA10HD Expands Hematopoietic Stem Cells and Ameliorates Murine β-Thalassemia. Molecular Therapy : the Journal of the American Society of Gene Therapy. PMID 28190779 DOI: 10.1016/j.ymthe.2017.01.019  0.472
2016 Cusan M, Vegi NM, Mulaw MA, Bamezai S, Kaiser LM, Deshpande AJ, Greif PA, Quintanilla-Fend L, Göllner S, Müller-Tidow C, Humphries KR, Armstrong SA, Hiddemann W, Feuring-Buske M, Buske C. Controlled stem cell amplification by HOXB4 depends on its unique proline-rich region near the N-terminus. Blood. PMID 27827825 DOI: 10.1182/Blood-2016-04-706978  0.485
2016 Samudio I, Rezvani K, Shaim H, Hofs E, Ngom M, Bu L, Liu G, Lee JT, Imren S, Lam V, Poon GF, Ghaedi M, Takei F, Humphries K, Jia W, et al. UV-inactivated HSV-1 potently activates NK cell killing of leukemic cells. Blood. PMID 26941401 DOI: 10.1182/Blood-2015-04-639088  0.321
2016 Pabst C, Bergeron A, Lavallée VP, Yeh J, Gendron P, Norddahl GL, Krosl J, Boivin I, Deneault E, Simard J, Imren S, Boucher G, Eppert K, Herold T, Bohlander SK, ... Humphries K, et al. GPR56 identifies primary human acute myeloid leukemia cells with high repopulating potential in vivo. Blood. PMID 26834243 DOI: 10.1182/Blood-2015-11-683649  0.69
2016 Abraham A, Kim YS, Zhao H, Humphries K, Persons DA. Increased Engraftment of Human Short Term Repopulating Hematopoietic Cells in NOD/SCID/IL2rγnull Mice by Lentiviral Expression of NUP98-HOXA10HD. Plos One. 11: e0147059. PMID 26761813 DOI: 10.1371/journal.pone.0147059  0.337
2015 Ruschmann J, Maetzig T, Krowiorz K, Kuchenbauer F, Petriv O, Hansen C, Humphries K. Assessment of candidate microRNAs to supress leukemic cell function using an inducible lentiviral vector system Experimental Hematology. 43: S92. DOI: 10.1016/J.Exphem.2015.06.242  0.397
2015 Lin H, Rothe K, Ruschmann J, Petriv O, O'Neill K, Knapp D, Brinkman R, Birol I, Forrest D, Hansen C, Eaves C, Humphries K, Jiang X. Comparative RNA-seq analyses identify new microRNA biomarkers and candidate target genes in patients’ drug-resistant CD34+ CML stem/progenitor cells Experimental Hematology. 43: S63. DOI: 10.1016/J.Exphem.2015.06.122  0.355
2014 Smith C, Gasparetto M, Humphries K, Pollyea DA, Vasiliou V, Jordan CT. Aldehyde dehydrogenases in acute myeloid leukemia. Annals of the New York Academy of Sciences. 1310: 58-68. PMID 24641679 DOI: 10.1111/Nyas.12414  0.446
2014 Xiang P, Wei W, Lo C, Rosten P, Hou J, Hoodless PA, Bilenky M, Bonifer C, Cockerill PN, Kirkpatrick A, Gottgens B, Hirst M, Humphries KR. Delineating MEIS1 cis-regulatory elements active in hematopoietic cells. Leukemia. 28: 433-6. PMID 24097337 DOI: 10.1038/Leu.2013.287  0.446
2013 Cellot S, Hope KJ, Chagraoui J, Sauvageau M, Deneault É, MacRae T, Mayotte N, Wilhelm BT, Landry JR, Ting SB, Krosl J, Humphries K, Thompson A, Sauvageau G. RNAi screen identifies Jarid1b as a major regulator of mouse HSC activity. Blood. 122: 1545-55. PMID 23777767 DOI: 10.1182/Blood-2013-04-496281  0.577
2011 Skrti? M, Sriskanthadevan S, Jhas B, Gebbia M, Wang X, Wang Z, Hurren R, Jitkova Y, Gronda M, Maclean N, Lai CK, Eberhard Y, Bartoszko J, Spagnuolo P, Rutledge AC, ... ... Humphries K, et al. Inhibition of mitochondrial translation as a therapeutic strategy for human acute myeloid leukemia. Cancer Cell. 20: 674-88. PMID 22094260 DOI: 10.1016/J.Ccr.2011.10.015  0.347
2011 Ji J, Risueño RM, Hong S, Allan D, Rosten P, Humphries K, Bhatia M. Brief report: ectopic expression of NUP98-HOXA10 augments erythroid differentiation of human embryonic stem cells. Stem Cells (Dayton, Ohio). 29: 736-41. PMID 21328509 DOI: 10.1002/Stem.622  0.505
2009 Reindl C, Quentmeier H, Petropoulos K, Greif PA, Benthaus T, Argiropoulos B, Mellert G, Vempati S, Duyster J, Buske C, Bohlander SK, Humphries KR, Hiddemann W, Spiekermann K. CBL exon 8/9 mutants activate the FLT3 pathway and cluster in core binding factor/11q deletion acute myeloid leukemia/myelodysplastic syndrome subtypes. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 15: 2238-47. PMID 19276253 DOI: 10.1158/1078-0432.CCR-08-1325  0.325
2008 Sekulovic S, Imren S, Humphries K. High level in vitro expansion of murine hematopoietic stem cells. Current Protocols in Stem Cell Biology. Unit 2A.7. PMID 18770636 DOI: 10.1002/9780470151808.sc02a07s4  0.439
2008 Sloma I, Imren S, Zhao Y, Humphries K, Eaves CJ. A Novel Strategy for Expanding Primitive Leukemic Cells from Chronic Phase CML Patients by Forced Overexpression of a NUP98-HOXA10 Homeodomain Fusion Gene. Blood. 112: 1078-1078. DOI: 10.1182/Blood.V112.11.1078.1078  0.405
2005 Cellot S, Krosl J, Humphries K, Sauvageau G. Deterministic Trigger of Self-Renewal in Expanded HSCs Expressing Hoxb4 + Antisense Pbx1. Blood. 106: 800-800. DOI: 10.1182/Blood.V106.11.800.800  0.728
2005 Krosl G, Giard M, Krosl J, Beauchemin S, Humphries K, Sauvageau G, Roy DC. Ex Vivo Expansion of Human SCID-Repopulating Cells Using Recombinant TAT-HOXB4 Protein. Blood. 106: 3159-3159. DOI: 10.1182/Blood.V106.11.3159.3159  0.634
2004 Beslu N, Krosl J, Laurin M, Mayotte N, Humphries KR, Sauvageau G. Molecular interactions involved in HOXB4-induced activation of HSC self-renewal. Blood. 104: 2307-14. PMID 15226173 DOI: 10.1182/Blood-2004-04-1653  0.599
2004 Cellot S, Krosl J, Humphries K, Sauvageau G. Revealing the Interplay of Extrinsic Versus Intrinsic Regulators of Self-Renewal in Hoxb4-Transduced HSCs. Blood. 104: 367-367. DOI: 10.1182/Blood.V104.11.367.367  0.726
2004 Palmqvist L, Pineault N, Argiropoulos B, Wan A, Humphries KR. FLT3 Expression Is Increased by MEIS1 and Collaborates with NUP98-HOX Fusion Genes in the Induction of Acute Myeloid Leukemia. Blood. 104: 2552-2552. DOI: 10.1182/Blood.V104.11.2552.2552  0.684
2004 Palmqvist L, Pineault N, Rosten P, Humphries KR. Redundant Leukemogenicity of NUP98-HOX Fusion Genes in Primary Murine Bone Marrow Cells Correlates with Gene Expression Changes Consistent with Common Key Target Genes. Blood. 104: 1134-1134. DOI: 10.1182/Blood.V104.11.1134.1134  0.638
2004 Humphries K. More complexity in MLL-associated leukemias Blood. 103: 1566-1567. DOI: 10.1182/Blood-2003-12-4282  0.356
2002 Thorsteinsdottir U, Mamo A, Kroon E, Jerome L, Bijl J, Lawrence HJ, Humphries K, Sauvageau G. Overexpression of the myeloid leukemia-associated Hoxa9 gene in bone marrow cells induces stem cell expansion. Blood. 99: 121-9. PMID 11756161 DOI: 10.1182/Blood.V99.1.121  0.656
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