A C. Karaplis - Publications

McGill University, Montreal, QC, Canada 
Cell Biology, Molecular Biology

37/126 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Bai X, Miao D, Xiao S, Qiu D, St-Arnaud R, Petkovich M, Gupta A, Goltzman D, Karaplis AC. CYP24 inhibition as a therapeutic target in FGF23-mediated renal phosphate wasting disorders. The Journal of Clinical Investigation. PMID 26784541 DOI: 10.1172/Jci81928  0.68
2015 Jiang M, Chen G, Lu N, Zhang Y, Jin S, Karaplis A, Goltzman D, Miao D. Deficiency of the PTHrP Nuclear Localization and Carboxyl Terminal Sequences Leads to Pre-mature Skin Aging Partially Mediated by the Upregulation of p27. Experimental Dermatology. PMID 26121068 DOI: 10.1111/Exd.12789  0.68
2015 Zhu M, Zhang J, Dong Z, Zhang Y, Wang R, Karaplis A, Goltzman D, Miao D. The p27 Pathway Modulates the Regulation of Skeletal Growth and Osteoblastic Bone Formation by Parathyroid Hormone-Related Peptide. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. PMID 25917430 DOI: 10.1002/Jbmr.2544  0.68
2014 Ma Y, Samaraweera M, Cooke-Hubley S, Kirby BJ, Karaplis AC, Lanske B, Kovacs CS. Neither absence nor excess of FGF23 disturbs murine fetal-placental phosphorus homeostasis or prenatal skeletal development and mineralization. Endocrinology. 155: 1596-605. PMID 24601885 DOI: 10.1210/En.2013-2061  0.68
2013 Raison D, Coquard C, Hochane M, Steger J, Massfelder T, Moulin B, Karaplis AC, Metzger D, Chambon P, Helwig JJ, Barthelmebs M. Knockdown of parathyroid hormone related protein in smooth muscle cells alters renal hemodynamics but not blood pressure. American Journal of Physiology. Renal Physiology. 305: F333-42. PMID 23720345 DOI: 10.1152/Ajprenal.00503.2012  0.68
2013 Romero JR, Youte R, Brown EM, Pollak MR, Goltzman D, Karaplis A, Pong LC, Chien L, Chattopadhyay N, Rivera A. Parathyroid hormone ablation alters erythrocyte parameters that are rescued by calcium-sensing receptor gene deletion European Journal of Haematology. 91: 37-45. PMID 23528155 DOI: 10.1111/Ejh.12110  0.68
2013 Kirby BJ, Ma Y, Martin HM, Buckle Favaro KL, Karaplis AC, Kovacs CS. Upregulation of calcitriol during pregnancy and skeletal recovery after lactation do not require parathyroid hormone. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. 28: 1987-2000. PMID 23505097 DOI: 10.1002/Jbmr.1925  0.68
2012 Panda DK, Goltzman D, Karaplis AC. Defective postnatal endochondral bone development by chondrocyte-specific targeted expression of parathyroid hormone type 2 receptor. American Journal of Physiology. Endocrinology and Metabolism. 303: E1489-501. PMID 23092913 DOI: 10.1152/Ajpendo.00254.2012  0.68
2012 Xue Y, Xiao Y, Liu J, Karaplis AC, Pollak MR, Brown EM, Miao D, Goltzman D. The calcium-sensing receptor complements parathyroid hormone-induced bone turnover in discrete skeletal compartments in mice. American Journal of Physiology. Endocrinology and Metabolism. 302: E841-51. PMID 22275754 DOI: 10.1152/Ajpendo.00599.2011  0.68
2011 Shu L, Ji J, Zhu Q, Cao G, Karaplis A, Pollak MR, Brown E, Goltzman D, Miao D. The calcium-sensing receptor mediates bone turnover induced by dietary calcium and parathyroid hormone in neonates. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. 26: 1057-71. PMID 21542007 DOI: 10.1002/Jbmr.300  0.68
2011 Karaplis AC, Chouha F, Djandji M, Sampalis JS, Hanley DA. Vitamin d status and response to daily 400 iu vitamin d3 and weekly alendronate 70 mg in men and women with osteoporosis | Niveles de vitamina d y respuesta a dosis diarias de 400 iu de vitamina d3 y semanales de 70 mg de alendronato en hombres y mujeres canadienses con osteoporosis Annals of Pharmacotherapy. 45: 561-568. PMID 21521859 DOI: 10.1345/Aph.1P439  0.68
2011 Kirby BJ, Ardeshirpour L, Woodrow JP, Wysolmerski JJ, Sims NA, Karaplis AC, Kovacs CS. Skeletal recovery after weaning does not require PTHrP. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. 26: 1242-51. PMID 21308774 DOI: 10.1002/Jbmr.339  0.68
2010 Sun W, Sun W, Liu J, Zhou X, Xiao Y, Karaplis A, Pollak MR, Brown E, Goltzman D, Miao D. Alterations in phosphorus, calcium and PTHrP contribute to defects in dental and dental alveolar bone formation in calcium-sensing receptor-deficient mice. Development (Cambridge, England). 137: 985-92. PMID 20150282 DOI: 10.1242/Dev.045898  0.68
2010 Simmonds CS, Karsenty G, Karaplis AC, Kovacs CS. Parathyroid hormone regulates fetal-placental mineral homeostasis. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. 25: 594-605. PMID 19968565 DOI: 10.1359/Jbmr.090825  0.68
2006 Hendy GN, Li T, Girard M, Feldstein RC, Mulay S, Desjardins R, Day R, Karaplis AC, Tremblay ML, Canaff L. Targeted ablation of the chromogranin A (Chga) gene: Normal neuroendocrine dense-core secretory granules and increased expression of other granins Molecular Endocrinology. 20: 1935-1947. PMID 16556729 DOI: 10.1210/Me.2005-0398  0.68
2003 Chan GK, Miao D, Deckelbaum R, Bolivar I, Karaplis A, Goltzman D. Parathyroid hormone-related peptide interacts with bone morphogenetic protein 2 to increase osteoblastogenesis and decrease adipogenesis in pluripotent C3H10T 1/2 mesenchymal cells. Endocrinology. 144: 5511-20. PMID 12960089 DOI: 10.1210/En.2003-0273  0.68
2003 Kos CH, Karaplis AC, Peng JB, Hediger MA, Goltzman D, Mohammad KS, Guise TA, Pollak MR. The calcium-sensing receptor is required for normal calcium homeostasis independent of parathyroid hormone. The Journal of Clinical Investigation. 111: 1021-8. PMID 12671051 DOI: 10.1172/Jci17416  0.68
2002 Deckelbaum RA, Chan G, Miao D, Goltzman D, Karaplis AC. Ihh enhances differentiation of CFK-2 chondrocytic cells and antagonizes PTHrP-mediated activation of PKA. Journal of Cell Science. 115: 3015-25. PMID 12082161  0.68
2001 Clemens TL, Cormier S, Eichinger A, Endlich K, Fiaschi-Taesch N, Fischer E, Friedman PA, Karaplis AC, Massfelder T, Rossert J, Schlüter KD, Silve C, Stewart AF, Takane K, Helwig JJ. Parathyroid hormone-related protein and its receptors: Nuclear functions and roles in the renal and cardiovascular systems, the placental trophoblasts and the pancreatic islets British Journal of Pharmacology. 134: 1113-1136. PMID 11704631 DOI: 10.1038/Sj.Bjp.0704378  0.68
2001 Chan GK, Deckelbaum RA, Bolivar I, Goltzman D, Karaplis AC. PTHrP inhibits adipocyte differentiation by down-regulating PPAR gamma activity via a MAPK-dependent pathway. Endocrinology. 142: 4900-9. PMID 11606458 DOI: 10.1210/Endo.142.11.8515  0.68
2001 He B, Deckelbaum RA, Miao D, Lipman ML, Pollak M, Goltzman D, Karaplis AC. Tissue-specific targeting of the pthrp gene: the generation of mice with floxed alleles. Endocrinology. 142: 2070-7. PMID 11316774 DOI: 10.1210/Endo.142.5.8146  0.68
2001 Chen Z, Karaplis AC, Ackerman SL, Pogribny IP, Melnyk S, Lussier-Cacan S, Chen MF, Pai A, John SW, Smith RS, Bottiglieri T, Bagley P, Selhub J, Rudnicki MA, James SJ, et al. Mice deficient in methylenetetrahydrofolate reductase exhibit hyperhomocysteinemia and decreased methylation capacity, with neuropathology and aortic lipid deposition. Human Molecular Genetics. 10: 433-43. PMID 11181567 DOI: 10.1093/Hmg/10.5.433  0.68
2000 Amizuka N, Henderson JE, White JH, Karaplis AC, Goltzman D, Sasaki T, Ozawa H. Recent studies on the biological action of parathyroid hormone (PTH)-related peptide (PTHrP) and PTH/PTHrP receptor in cartilage and bone Histology and Histopathology. 15: 957-970. PMID 10963138 DOI: 10.14670/Hh-15.957  0.68
1998 Karaplis AC, Deckelbaum RA. Role of PTHrP and PTH-1 receptor in endochondral bone development. Frontiers in Bioscience : a Journal and Virtual Library. 3: d795-803. PMID 9683888  0.68
1998 Lipman ML, Panda D, Bennett HPJ, Henderson JE, Shane E, Shen Y, Goltzman D, Karaplis AC. Cloning of human PEX cDNA: Expression, subcellular localization, and endopeptidase activity Journal of Biological Chemistry. 273: 13729-13737. PMID 9593714 DOI: 10.1074/Jbc.273.22.13729  0.68
1997 Shane E, Parisien M, Henderson JE, Dempster DW, Feldman F, Hardy MA, Tohme JF, Karaplis AC, Clemens TL. Tumor-induced osteomalacia: Clinical and basic studies Journal of Bone and Mineral Research. 12: 1502-1511. PMID 9286768 DOI: 10.1359/Jbmr.1997.12.9.1502  0.68
1997 Rabbani SA, Harakidas P, Gladu J, Srivastava S, Diarra A, Sauvé R, Karaplis AC, Henderson JE, Goltzman D, Hendy GN. Expression and characterization of recombinant rat parathyroid hormone-related peptide (1-141) and an amino-terminally-truncated analogue (38-141) Molecular and Cellular Endocrinology. 130: 13-21. PMID 9220017 DOI: 10.1016/S0303-7207(97)00068-3  0.68
1996 Lee K, Lanske B, Karaplis AC, Deeds JD, Kohno H, Nissenson RA, Kronenberg HM, Segre GV. Parathyroid hormone-related peptide delays terminal differentiation of chondrocytes during endochondral bone development. Endocrinology. 137: 5109-18. PMID 8895385 DOI: 10.1210/Endo.137.11.8895385  0.68
1996 Amizuka N, Henderson JE, Hoshi K, Warshawsky H, Ozawa H, Goltzman D, Karaplis AC. Programmed cell death of chondrocytes and aberrant chondrogenesis in mice homozygous for parathyroid hormone-related peptide gene deletion Endocrinology. 137: 5055-5067. PMID 8895380 DOI: 10.1210/Endo.137.11.8895380  0.68
1996 Henderson JE, He B, Goltzman D, Karaplis AC. Constitutive expression of parathyroid hormone-related peptide (PTHrP) stimulates growth and inhibit differentiation of CFK2 chondrocytes Journal of Cellular Physiology. 169: 33-41. PMID 8841420 DOI: 10.1002/(Sici)1097-4652(199610)169:1<33::Aid-Jcp4>3.0.Co;2-F  0.68
1996 Sidler B, Alpert L, Henderson JE, Deckelbaum R, Amizuka N, Silva JE, Goltzman D, Karaplis AC. Amplification of the parathyroid hormone-related peptide gene in a colonic carcinoma Journal of Clinical Endocrinology and Metabolism. 81: 2841-2847. PMID 8768840 DOI: 10.1210/Jcem.81.8.8768840  0.68
1996 Amizuka N, Karaplis AC, Henderson JE, Warshawsky H, Lipman ML, Matsuki Y, Ejiri S, Tanaka M, Izumi N, Ozawa H, Goltzman D. Haploinsufficiency of parathyroid hormone-related peptide (PTHrP) results in abnormal postnatal bone development Developmental Biology. 175: 166-176. PMID 8608863 DOI: 10.1006/Dbio.1996.0104  0.68
1995 Henderson JE, Amizuka N, Warshawsky H, Biasotto D, Lanske BMK, Goltzman D, Karaplis AC. Nucleolar localization of parathyroid hormone-related peptide enhances survival of chondrocytes under conditions that promote apoptotic cell death Molecular and Cellular Biology. 15: 4064-4075. PMID 7623802 DOI: 10.1128/Mcb.15.8.4064  0.68
1994 Karaplis AC, Luz A, Glowacki J, Bronson RT, Tybulewicz VL, Kronenberg HM, Mulligan RC. Lethal skeletal dysplasia from targeted disruption of the parathyroid hormone-related peptide gene. Genes & Development. 8: 277-89. PMID 8314082 DOI: 10.1101/Gad.8.3.277  0.68
1994 Amizuka N, Warshawsky H, Henderson JE, Goltzman D, Karaplis AC. Parathyroid hormone-related peptide-depleted mice show abnormal epiphyseal cartilage development and altered endochondral bone formation Journal of Cell Biology. 126: 1611-1623. PMID 8089190 DOI: 10.1083/Jcb.126.6.1611  0.68
1992 Baba H, Karaplis AC, Wiren KM, Keutmann HT, Kronenberg HM. Interaction of nascent preproparathyroid hormone molecules with microsomal membranes Journal of Bone and Mineral Research. 7: 199-206. PMID 1570764 DOI: 10.1002/Jbmr.5650070211  0.68
1991 Kremer R, Karaplis AC, Henderson J, Gulliver W, Banville D, Hendy GN, Goltzman D. Regulation of parathyroid hormone-like peptide in cultured normal human keratinocytes: Effect of growth factors and 1,25 dihydroxyvitamin D3 on gene expression and secretion Journal of Clinical Investigation. 87: 884-893. PMID 1999499 DOI: 10.1172/Jci115094  0.68
Low-probability matches
2018 Zhu Q, Zhou X, Zhu M, Wang Q, Goltzman D, Karaplis A, Miao D. Endogenous Parathyroid Hormone-Related Protein Compensates for the Absence of Parathyroid Hormone in Promoting Bone Accrual In Vivo in a Model of Bone Marrow Ablation. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. 33: 2239-2241. PMID 30521118 DOI: 10.1002/Jbmr.3582  0.2
2018 Zhang Y, Chen G, Gu Z, Sun H, Karaplis A, Goltzman D, Miao D. DNA damage checkpoint pathway modulates the regulation of skeletal growth and osteoblastic bone formation by parathyroid hormone-related peptide. International Journal of Biological Sciences. 14: 508-517. PMID 29805302 DOI: 10.7150/Ijbs.23318  0.2
2017 Nguyen-Yamamoto L, Karaplis AC, St-Arnaud R, Goltzman D. Fibroblast Growth Factor 23 Regulation by Systemic and Local Osteoblast-Synthesized 1,25-Dihydroxyvitamin D. Journal of the American Society of Nephrology : Jasn. 28: 586-597. PMID 27535551 DOI: 10.1681/Asn.2016010066  0.2
2016 Camirand A, Goltzman D, Gupta A, Kaouass M, Panda D, Karaplis A. The Role of Parathyroid Hormone-Related Protein (PTHrP) in Osteoblast Response to Microgravity: Mechanistic Implications for Osteoporosis Development. Plos One. 11: e0160034. PMID 27463808 DOI: 10.1371/Journal.Pone.0160034  0.2
2016 Zhou X, Dai X, Wu X, Ji J, Karaplis A, Goltzman D, Yang X, Miao D. Overexpression of Bmi1 in Lymphocytes Stimulates Skeletogenesis by Improving the Osteogenic Microenvironment. Scientific Reports. 6: 29171. PMID 27373231 DOI: 10.1038/Srep29171  0.2
2016 Sun W, Wu J, Huang L, Liu H, Wang R, Karaplis A, Goltzman D, Miao D. PTHrP nuclear localization and carboxyl terminus sequences modulate dental and mandibular development in part via the action of p27. Endocrinology. en20151555. PMID 26859332 DOI: 10.1210/En.2015-1555  0.2
2015 Hirai T, Kobayashi T, Nishimori S, Karaplis AC, Goltzman D, Kronenberg HM. Bone Is a Major Target of PTH/PTHrP Receptor Signaling in Regulation of Fetal Blood Calcium Homeostasis. Endocrinology. 156: 2774-80. PMID 26052897 DOI: 10.1210/En.2014-1835  0.2
2013 Zhu Q, Zhou X, Zhu M, Wang Q, Goltzman D, Karaplis A, Miao D. Endogenous parathyroid hormone-related protein compensates for the absence of parathyroid hormone in promoting bone accrual in vivo in a model of bone marrow ablation. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. 28: 1898-911. PMID 23716486 DOI: 10.1002/Jbmr.2000  0.2
2013 Liu XL, Lu YS, Gao JY, Marshall C, Xiao M, Miao DS, Karaplis A, Goltzman D, Ding J. Calcium sensing receptor absence delays postnatal brain development via direct and indirect mechanisms. Molecular Neurobiology. 48: 590-600. PMID 23564401 DOI: 10.1007/S12035-013-8448-0  0.2
2012 Gu Z, Liu Y, Zhang Y, Jin S, Chen Q, Goltzman D, Karaplis A, Miao D. Absence of PTHrP nuclear localization and carboxyl terminus sequences leads to abnormal brain development and function. Plos One. 7: e41542. PMID 22844494 DOI: 10.1371/Journal.Pone.0041542  0.2
2011 Liu J, Lv F, Sun W, Tao C, Ding G, Karaplis A, Brown E, Goltzman D, Miao D. The abnormal phenotypes of cartilage and bone in calcium-sensing receptor deficient mice are dependent on the actions of calcium, phosphorus, and PTH. Plos Genetics. 7: e1002294. PMID 21966280 DOI: 10.1371/Journal.Pgen.1002294  0.2
2011 Ren Y, Liu B, Feng Y, Shu L, Cao X, Karaplis A, Goltzman D, Miao D. Endogenous PTH deficiency impairs fracture healing and impedes the fracture-healing efficacy of exogenous PTH(1-34). Plos One. 6: e23060. PMID 21829585 DOI: 10.1371/Journal.Pone.0023060  0.2
2011 Chen L, Liu H, Sun W, Bai X, Karaplis AC, Goltzman D, Miao D. Fibroblast growth factor 23 overexpression impacts negatively on dentin mineralization and dentinogenesis in mice. Clinical and Experimental Pharmacology & Physiology. 38: 395-402. PMID 21488937 DOI: 10.1111/J.1440-1681.2011.05526.X  0.2
2010 Zhang HW, Ding J, Jin JL, Guo J, Liu JN, Karaplis A, Goltzman D, Miao D. Defects in mesenchymal stem cell self-renewal and cell fate determination lead to an osteopenic phenotype in Bmi-1 null mice. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. 25: 640-52. PMID 19653817 DOI: 10.1359/Jbmr.090812  0.2
2009 Liu H, Guo J, Wang L, Chen N, Karaplis A, Goltzman D, Miao D. Distinctive anabolic roles of 1,25-dihydroxyvitamin D(3) and parathyroid hormone in teeth and mandible versus long bones. The Journal of Endocrinology. 203: 203-13. PMID 19713218 DOI: 10.1677/Joe-09-0247  0.2
2009 Panda D, Goltzman D, Jüppner H, Karaplis AC. TIP39/parathyroid hormone type 2 receptor signaling is a potent inhibitor of chondrocyte proliferation and differentiation. American Journal of Physiology. Endocrinology and Metabolism. 297: E1125-36. PMID 19706789 DOI: 10.1152/Ajpendo.00254.2009  0.2
2009 Liu P, Bai X, Wang H, Karaplis A, Goltzman D, Miao D. Hypophosphatemia-mediated hypotension in transgenic mice overexpressing human FGF-23. American Journal of Physiology. Heart and Circulatory Physiology. 297: H1514-20. PMID 19684183 DOI: 10.1152/Ajpheart.00581.2009  0.2
2009 Bai X, Dinghong Q, Miao D, Goltzman D, Karaplis AC. Klotho ablation converts the biochemical and skeletal alterations in FGF23 (R176Q) transgenic mice to a Klotho-deficient phenotype. American Journal of Physiology. Endocrinology and Metabolism. 296: E79-88. PMID 18984852 DOI: 10.1152/Ajpendo.90539.2008  0.2
2009 Cao G, Gu Z, Ren Y, Shu L, Tao C, Karaplis A, Goltzman D, Miao D. Parathyroid hormone contributes to regulating milk calcium content and modulates neonatal bone formation cooperatively with calcium. Endocrinology. 150: 561-9. PMID 18832101 DOI: 10.1210/En.2008-0654  0.2
2008 Miao D, Su H, He B, Gao J, Xia Q, Zhu M, Gu Z, Goltzman D, Karaplis AC. Severe growth retardation and early lethality in mice lacking the nuclear localization sequence and C-terminus of PTH-related protein. Proceedings of the National Academy of Sciences of the United States of America. 105: 20309-14. PMID 19091948 DOI: 10.1073/Pnas.0805690105  0.2
2008 Gupta A, Välimäki VV, J Välimäki M, Löyttyniemi E, Richard M, L Bukka P, Goltzman D, Karaplis AC. Variable number of tandem repeats polymorphism in parathyroid hormone-related protein as predictor of peak bone mass in young healthy Finnish males. European Journal of Endocrinology / European Federation of Endocrine Societies. 158: 755-64. PMID 18426836 DOI: 10.1530/Eje-07-0886  0.2
2007 Bai X, Miao D, Goltzman D, Karaplis AC. Early lethality in Hyp mice with targeted deletion of Pth gene. Endocrinology. 148: 4974-83. PMID 17615144 DOI: 10.1210/En.2007-0243  0.2
2007 Gao J, Tiwari-Pandey R, Samadfam R, Yang Y, Miao D, Karaplis AC, Sairam MR, Goltzman D. Altered ovarian function affects skeletal homeostasis independent of the action of follicle-stimulating hormone. Endocrinology. 148: 2613-21. PMID 17332067 DOI: 10.1210/En.2006-1404  0.2
2006 Xue Y, Karaplis AC, Hendy GN, Goltzman D, Miao D. Exogenous 1,25-dihydroxyvitamin D3 exerts a skeletal anabolic effect and improves mineral ion homeostasis in mice that are homozygous for both the 1alpha-hydroxylase and parathyroid hormone null alleles. Endocrinology. 147: 4801-10. PMID 16857747 DOI: 10.1210/En.2006-0403  0.2
2005 Xue Y, Zhang Z, Karaplis AC, Hendy GN, Goltzman D, Miao D. Exogenous PTH-related protein and PTH improve mineral and skeletal status in 25-hydroxyvitamin D-1alpha-hydroxylase and PTH double knockout mice. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. 20: 1766-77. PMID 16160734 DOI: 10.1359/Jbmr.050608  0.2
2005 Miao D, He B, Jiang Y, Kobayashi T, Sorocéanu MA, Zhao J, Su H, Tong X, Amizuka N, Gupta A, Genant HK, Kronenberg HM, Goltzman D, Karaplis AC. Osteoblast-derived PTHrP is a potent endogenous bone anabolic agent that modifies the therapeutic efficacy of administered PTH 1-34. The Journal of Clinical Investigation. 115: 2402-11. PMID 16138191 DOI: 10.1172/Jci24918  0.2
2005 Xue Y, Karaplis AC, Hendy GN, Goltzman D, Miao D. Genetic models show that parathyroid hormone and 1,25-dihydroxyvitamin D3 play distinct and synergistic roles in postnatal mineral ion homeostasis and skeletal development. Human Molecular Genetics. 14: 1515-28. PMID 15843402 DOI: 10.1093/Hmg/Ddi160  0.2
2004 Sorocéanu MA, Miao D, Bai XY, Su H, Goltzman D, Karaplis AC. Rosiglitazone impacts negatively on bone by promoting osteoblast/osteocyte apoptosis. The Journal of Endocrinology. 183: 203-16. PMID 15525588 DOI: 10.1677/Joe.1.05723  0.2
2004 Bai X, Miao D, Li J, Goltzman D, Karaplis AC. Transgenic mice overexpressing human fibroblast growth factor 23 (R176Q) delineate a putative role for parathyroid hormone in renal phosphate wasting disorders. Endocrinology. 145: 5269-79. PMID 15284207 DOI: 10.1210/En.2004-0233  0.2
2004 Miao D, Li J, Xue Y, Su H, Karaplis AC, Goltzman D. Parathyroid hormone-related peptide is required for increased trabecular bone volume in parathyroid hormone-null mice. Endocrinology. 145: 3554-62. PMID 15090463 DOI: 10.1210/En.2003-1695  0.2
2004 Miao D, Bai X, Panda DK, Karaplis AC, Goltzman D, McKee MD. Cartilage abnormalities are associated with abnormal Phex expression and with altered matrix protein and MMP-9 localization in Hyp mice. Bone. 34: 638-47. PMID 15050894 DOI: 10.1016/J.Bone.2003.12.015  0.2
2004 Miao D, He B, Lanske B, Bai XY, Tong XK, Hendy GN, Goltzman D, Karaplis AC. Skeletal abnormalities in Pth-null mice are influenced by dietary calcium. Endocrinology. 145: 2046-53. PMID 14701672 DOI: 10.1210/En.2003-1097  0.2
2003 Bai XY, Miao D, Goltzman D, Karaplis AC. The autosomal dominant hypophosphatemic rickets R176Q mutation in fibroblast growth factor 23 resists proteolytic cleavage and enhances in vivo biological potency. The Journal of Biological Chemistry. 278: 9843-9. PMID 12519781 DOI: 10.1074/Jbc.M210490200  0.2
2002 Bai X, Miao D, Panda D, Grady S, McKee MD, Goltzman D, Karaplis AC. Partial rescue of the Hyp phenotype by osteoblast-targeted PHEX (phosphate-regulating gene with homologies to endopeptidases on the X chromosome) expression. Molecular Endocrinology (Baltimore, Md.). 16: 2913-25. PMID 12456809 DOI: 10.1210/Me.2002-0113  0.2
2002 Miao D, He B, Karaplis AC, Goltzman D. Parathyroid hormone is essential for normal fetal bone formation. The Journal of Clinical Investigation. 109: 1173-82. PMID 11994406 DOI: 10.1172/Jci14817  0.2
2001 Miao D, Bai X, Panda D, McKee MD, Karaplis AC, Goltzman D. Osteomalacia in Hyp Mice Is Associated with Abnormal Phex Expression and with Altered Bone Matrix Protein Expression and Deposition* *This work was support by Grants MT-5775 (to D.G.) and GR-13297 (to A.C.K.) from the Medical Research Council of Canada, Grant 00731 (to D.G.) from the NCI of Canada, and Grant MT-11360 (to M.D.M.) from the Canadian Institutes for Health Research. Endocrinology. 142: 926-939. PMID 28201145 DOI: 10.1210/Endo.142.2.7976  0.2
2000 Karaplis AC, Goltzman D. PTH and PTHrP effects on the skeleton. Reviews in Endocrine & Metabolic Disorders. 1: 331-41. PMID 11706747 DOI: 10.1023/A:1026526703898  0.2
2000 Goltzman D, Karaplis AC, Kremer R, Rabbani SA. Molecular basis of the spectrum of skeletal complications of neoplasia. Cancer. 88: 2903-8. PMID 10898332 DOI: 10.1002/1097-0142(20000615)88:12+<2903::AID-CNCR4>3.0.CO;2-G  0.2
1990 Karaplis AC, Yasuda T, Hendy GN, Goltzman D, Banville D. Gene-encoding parathyroid hormone-like peptide: nucleotide sequence of the rat gene and comparison with the human homologue. Molecular Endocrinology (Baltimore, Md.). 4: 441-6. PMID 2342478 DOI: 10.1210/Mend-4-3-441  0.2
2020 Xue Y, Zhang Z, Karaplis AC, Hendy GN, Goltzman And D, Miao D. Exogenous PTH-Related Protein and PTH Improve Mineral and Skeletal Status in 25-Hydroxyvitamin D-1α-Hydroxylase and PTH Double Knockout Mice. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. 35: 1614-1616. PMID 32790166 DOI: 10.1002/jbmr.4093  0.16
2011 Liu P, Chen L, Bai X, Karaplis A, Miao D, Gu N. Impairment of spatial learning and memory in transgenic mice overexpressing human fibroblast growth factor-23. Brain Research. 1412: 9-17. PMID 21824606 DOI: 10.1016/J.Brainres.2011.07.028  0.16
2004 Shin HI, Divieti P, Sims NA, Kobayashi T, Miao D, Karaplis AC, Baron R, Bringhurst R, Kronenberg HM. Gp130-mediated signaling is necessary for normal osteoblastic function in vivo and in vitro. Endocrinology. 145: 1376-85. PMID 14617570 DOI: 10.1210/En.2003-0839  0.16
2003 VanHouten JN, Dann P, Stewart AF, Watson CJ, Pollak M, Karaplis AC, Wysolmerski JJ. Mammary-specific deletion of parathyroid hormone-related protein preserves bone mass during lactation. The Journal of Clinical Investigation. 112: 1429-36. PMID 14597768 DOI: 10.1172/Jci19504  0.12
2002 He B, Tong TK, Hiou-Tim FF, Al-Akad B, Kronenberg HM, Karaplis AC. The murine gene encoding parathyroid hormone: genomic organization, nucleotide sequence and transcriptional regulation. Journal of Molecular Endocrinology. 29: 193-203. PMID 12370121 DOI: 10.1677/Jme.0.0290193  0.12
2001 Nguyen MT, He B, Karaplis AC. Nuclear Forms of Parathyroid Hormone-Related Peptide Are Translated from Non-AUG Start Sites Downstream from the Initiator Methionine**This work was supported by the Canadian Arthritis Network and the Medical Research Council (MRC) of Canada. Endocrinology. 142: 694-703. PMID 28201336 DOI: 10.1210/Endo.142.2.7944  0.12
1998 Karaplis AC, He B, Nguyen MT, Young ID, Semeraro D, Ozawa H, Amizuka N. Inactivating mutation in the human parathyroid hormone receptor type 1 gene in Blomstrand chondrodysplasia. Endocrinology. 139: 5255-8. PMID 9832466 DOI: 10.1210/Endo.139.12.6522  0.12
1998 Beck L, Karaplis AC, Amizuka N, Hewson AS, Ozawa H, Tenenhouse HS. Targeted inactivation of Npt2 in mice leads to severe renal phosphate wasting, hypercalciuria, and skeletal abnormalities. Proceedings of the National Academy of Sciences of the United States of America. 95: 5372-7. PMID 9560283 DOI: 10.1073/PNAS.95.9.5372  0.04
2019 Zhang R, Li J, Assaker G, Camirand A, Sabri S, Karaplis AC, Kremer R. Parathyroid Hormone-Related Protein (PTHrP): An Emerging Target in Cancer Progression and Metastasis. Advances in Experimental Medicine and Biology. 1164: 161-178. PMID 31576548 DOI: 10.1007/978-3-030-22254-3_13  0.01
2018 Panda D, Bai X, Sabbagh Y, Zhang Y, Zaun HC, Karellis A, Koromilas AE, Lipman M, Karaplis AC. Defective Interplay Between mTORC1 Activity and Endoplasmic Reticulum Stress-Unfolded Protein Response in Uremic Vascular Calcification. American Journal of Physiology. Renal Physiology. PMID 29357413 DOI: 10.1152/Ajprenal.00350.2017  0.01
2018 Zhang R, Li J, Badescu D, Karaplis A, Ragoussis J, Kremer R. Abstract 1995: PTHrP drives tumor initiation signaling pathways in the PyMT model of breast cancer progression Tumor Biology. DOI: 10.1158/1538-7445.Am2018-1995  0.01
2017 Okumura K, Saito M, Yoshizawa Y, Munakata H, Isogai E, Miura I, Wakana S, Yamaguchi M, Shitara H, Taya C, Karaplis AC, Kominami R, Wakabayashi Y. The parathyroid hormone regulates skin tumour susceptibility in mice. Scientific Reports. 7: 11208. PMID 28894263 DOI: 10.1038/S41598-017-11561-X  0.01
2017 Radi S, Karaplis AC. A Case of Male Osteoporosis: A 37-Year-Old Man with Multiple Vertebral Compression Fractures. Case Reports in Endocrinology. 2017: 6328524. PMID 28791186 DOI: 10.1155/2017/6328524  0.01
2017 Zhang R, Li J, Karaplis AC, Kremer R. Abstract 4775: PTHrP regulate CSC and promote EMT in the PyMT model of breast cancer progression Cancer Research. 77: 4775-4775. DOI: 10.1158/1538-7445.Am2017-4775  0.01
2016 Ma Y, Kirby BJ, Fairbridge NA, Karaplis AC, Lanske B, Kovacs CS. FGF23 is not required to regulate fetal phosphorus metabolism but exerts effects within 12 hours after birth. Endocrinology. en20161369. PMID 27929669 DOI: 10.1210/En.2016-1369  0.01
2016 Ma Y, Kirby BJ, Lanske B, Karaplis AC, Kovacs CS. Fibroblast Growth Factor-23 (FGF23) Exerts its Effects on Phosphorus Metabolism Starting 12 Hours after Birth, but not During Fetal Fevelopment Canadian Journal of Diabetes. 40: S2-S3. DOI: 10.1016/J.JCJD.2016.08.006  0.01
2014 Boras-Granic K, Dann P, VanHouten J, Karaplis A, Wysolmerski J. Deletion of the Nuclear Localization Sequences and C-Terminus of PTHrP Impairs Embryonic Mammary Development but also Inhibits PTHrP Production Plos One. 9. PMID 24785493 DOI: 10.1371/Journal.Pone.0090418  0.01
2013 Wang YH, Qiu Y, Han XD, Xiong J, Chen YX, Shi HF, Karaplis A. Haploinsufficiency of endogenous parathyroid hormone-related peptide impairs bone fracture healing. Clinical and Experimental Pharmacology & Physiology. 40: 715-23. PMID 23937065 DOI: 10.1111/1440-1681.12161  0.01
2013 Morin SN, Godbout B, Wall M, Belzile EL, Michou L, Ste-Marie L, Karaplis AC, de GJA, Brown JP. Femur geometrical parameters in the pathogenesis of atypical femur fractures Bone Abstracts. DOI: 10.1530/Boneabs.01.Oc1.6  0.01
2013 Li J, Karaplis AC, Huang DC, Siegel PM, Camirand A, Yang XF, Muller WJ, Kremer R. Abstract 89: Parathyroid Hormone-related Protein (PTHrP) is critical for breast tumour metastasis and may constitute a novel target for therapeutic intervention. Cancer Research. 73: 89-89. DOI: 10.1158/1538-7445.Am2013-89  0.01
2012 Karaplis AC, Bai X, Falet JP, Macica CM. Mineralizing enthesopathy is a common feature of renal phosphate-wasting disorders attributed to FGF23 and is exacerbated by standard therapy in hyp mice. Endocrinology. 153: 5906-17. PMID 23038738 DOI: 10.1016/J.Semarthrit.2012.12.019  0.01
2011 Li J, Karaplis AC, Huang DC, Siegel PM, Camirand A, Yang XF, Muller WJ, Kremer R. PTHrP drives breast tumor initiation, progression, and metastasis in mice and is a potential therapy target. The Journal of Clinical Investigation. 121: 4655-69. PMID 22056386 DOI: 10.1172/Jci46134  0.01
2011 Kremer R, Li J, Camirand A, Karaplis AC. Parathyroid hormone related protein (PTHrP) in tumor progression. Advances in Experimental Medicine and Biology. 720: 145-60. PMID 21901625 DOI: 10.1007/978-1-4614-0254-1_12  0.01
2011 Kirby B, Karaplis A, Kovacs C. Calcitriol increases during pregnancy and bone formation upregulates post-lactation without parathyroid hormone Bone. 48: S101-S102. DOI: 10.1016/J.Bone.2011.03.155  0.01
2010 Ji J, Miao D, He B, Karaplis A, Goltzman D. The coordinated action of parathyroid hormone and parathyroid hormone related peptide is essential for normal fetal axial skeletal development Bone. 47: S363. DOI: 10.1016/J.Bone.2010.09.095  0.01
2008 Shu L, Cao G, Ren Y, Karaplis A, Goltzman D, Miao D. The calcium sensing receptor mediates bone turnover induced by dietary calcium and parathyroid hormone Bone. 43: S49. DOI: 10.1016/J.Bone.2008.08.033  0.01
2008 Sun W, Liu J, Karaplis A, Goltzman D, Miao D. Alterations in phosphorus, calcium and PTHrP appear to contribute to defects of dental formation in calcium-sensing receptor deficient mice Bone. 43: S49. DOI: 10.1016/J.Bone.2008.08.032  0.01
2008 Liu J, Tao C, Sun W, Karaplis A, Goltzman D, Miao D. The abnormal phenotypes of cartilage and bone in calcium-sensing receptor deficient mice are dependent on the actions of calcium, phosphorus and parathyroid hormone Bone. 43: S31. DOI: 10.1016/J.Bone.2008.07.034  0.01
2005 Bedard N, Hingamp P, Pang Z, Karaplis A, Morales C, Trasler J, Cyr D, Gagnon C, Wing SS. Mice lacking the UBC4-testis gene have a delay in postnatal testis development but normal spermatogenesis and fertility. Molecular and Cellular Biology. 25: 6346-54. PMID 16024774 DOI: 10.1128/Mcb.25.15.6346-6354.2005  0.01
2004 Amizuka N, Henderson JE, White JH, Oda K, Li M, Nozawa-Inoue K, Kawano Y, Suzuki A, Karaplis AC, Goltzman D, Maeda T. Morphological Approach to Biological Action of PTHrP and Vitamin D3 on Endochondral Ossification Journal of Oral Biosciences. 46: 79-96. DOI: 10.1016/S1349-0079(04)80020-3  0.01
2001 Garfield N, Karaplis AC. Genetics and animal models of hypoparathyroidism. Trends in Endocrinology and Metabolism: Tem. 12: 288-94. PMID 11504667 DOI: 10.1016/S1043-2760(01)00435-0  0.01
2001 Karaplis AC. PTHrP: novel roles in skeletal biology. Current Pharmaceutical Design. 7: 655-70. PMID 11375774  0.01
2000 Karaplis AC. Metabolic bone disease: Lessons from knockout mice Drug Development Research. 49: 159-166. DOI: 10.1002/(Sici)1098-2299(200003)49:3<159::Aid-Ddr6>3.0.Co;2-L  0.01
1999 Serra R, Karaplis A, Sohn P. Parathyroid hormone-related peptide (PTHrP)-dependent and -independent effects of transforming growth factor beta (TGF-beta) on endochondral bone formation. The Journal of Cell Biology. 145: 783-94. PMID 10330406 DOI: 10.1083/Jcb.145.4.783  0.01
1998 Dunbar ME, Young P, Zhang J, McCaughern-Carucci J, Lanske B, Orloff JJ, Karaplis A, Cunha G, Wysolmerski JJ. Stromal Cells Are Critical Targets in the Regulation of Mammary Ductal Morphogenesis by Parathyroid Hormone-Related Protein Developmental Biology. 203: 75-89. PMID 9806774 DOI: 10.1006/Dbio.1998.9029  0.01
1998 Philbrick WM, Dreyer BE, Nakchbandi IA, Karaplis AC. Parathyroid hormone-related protein is required for tooth eruption. Proceedings of the National Academy of Sciences of the United States of America. 95: 11846-51. PMID 9751753 DOI: 10.1073/Pnas.95.20.11846  0.01
1998 Nguyen MT, Karaplis AC. The nucleus: a target site for parathyroid hormone-related peptide (PTHrP) action. Journal of Cellular Biochemistry. 70: 193-9. PMID 9671225 DOI: 10.1002/(Sici)1097-4644(19980801)70:2<193::Aid-Jcb5>3.0.Co;2-J  0.01
1997 Karaplis AC, Vautour L. Parathyroid hormone-related peptide and the parathyroid hormone/parathyroid hormone-related peptide receptor in skeletal development. Current Opinion in Nephrology and Hypertension. 6: 308-13. PMID 9263678 DOI: 10.1097/00041552-199707000-00002  0.01
1996 Kovacs CS, Lanske B, Hunzelman JL, Guo J, Karaplis AC, Kronenberg HM. Parathyroid hormone-related peptide (PTHrP) regulates fetal-placental calcium transport through a receptor distinct from the PTH/PTHrP receptor. Proceedings of the National Academy of Sciences of the United States of America. 93: 15233-8. PMID 8986793 DOI: 10.1073/Pnas.93.26.15233  0.01
1996 Karaplis AC, Kronenberg HM. Physiological roles for parathyroid hormone-related protein: lessons from gene knockout mice. Vitamins and Hormones. 52: 177-93. PMID 8909161 DOI: 10.1016/S0083-6729(08)60411-2  0.01
1996 Kronenberg HM, Karaplis AC, Lanske B. Role of parathyroid hormone-related protein in skeletal development. Annals of the New York Academy of Sciences. 785: 119-23. PMID 8702116 DOI: 10.1111/J.1749-6632.1996.Tb56249.X  0.01
1996 Lanske B, Karaplis AC, Lee K, Luz A, Vortkamp A, Pirro A, Karperien M, Defize LH, Ho C, Mulligan RC, Abou-Samra AB, Jüppner H, Segre GV, Kronenberg HM. PTH/PTHrP receptor in early development and Indian hedgehog-regulated bone growth. Science (New York, N.Y.). 273: 663-6. PMID 8662561 DOI: 10.1126/Science.273.5275.663  0.01
1996 Katchan B, Karaplis AC, Bégin LR, Trifiro M. Hypercalcaemia with lymphoedema. Lancet (London, England). 347: 161. PMID 8544552  0.01
1995 Karaplis AC, Lim SK, Baba H, Arnold A, Kronenberg HM. Inefficient membrane targeting, translocation, and proteolytic processing by signal peptidase of a mutant preproparathyroid hormone protein. The Journal of Biological Chemistry. 270: 1629-35. PMID 7829495 DOI: 10.1074/Jbc.270.4.1629  0.01
1993 Schipani E, Karga H, Karaplis AC, Potts JT, Kronenberg HM, Segre GV, Abou-Samra AB, Jüppner H. Identical complementary deoxyribonucleic acids encode a human renal and bone parathyroid hormone (PTH)/PTH-related peptide receptor. Endocrinology. 132: 2157-65. PMID 8386612 DOI: 10.1210/Endo.132.5.8386612  0.01
1992 Schipani E, Abou-Samra A, Karaplis A, Kronenberg H, Segre G, Jüppner H. Molecular cloning of human PTH/PTHrP receptor cDNAs Bone and Mineral. 17: 126. DOI: 10.1016/0169-6009(92)91843-8  0.01
1989 Karaplis AC, Funk CD, Powell WS. Binding of prostaglandin E2 to cultured bovine adrenal chromaffin cells and its effect on catecholamine secretion. Biochimica Et Biophysica Acta. 1010: 369-76. PMID 2537658 DOI: 10.1016/0167-4889(89)90064-5  0.01
1984 Karaplis AC, Powell WS. Subcellular localization of prostaglandin E2 binding sites in bovine adrenal medulla. Biochimica Et Biophysica Acta. 801: 189-96. PMID 6148108 DOI: 10.1016/0304-4165(84)90067-9  0.01
1981 Karaplis AC, Powell WS. Prostaglandin E-binding sites in the fetal adrenal. Endocrinology. 109: 2124-8. PMID 6118260 DOI: 10.1210/Endo-109-6-2124  0.01
1981 Karaplis AC, Powell WS. Specific binding of prostaglandins E1 and E2 to adrenal medulla. The Journal of Biological Chemistry. 256: 2414-9. PMID 6109728  0.01
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