Luke J. Whitesell - Publications

University of Arizona, Tucson, AZ 
Oncology, Cell Biology, Molecular Biology

91 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Nishida Y, Zhao R, Heese LE, Akiyama H, Patel S, Jaeger AM, Jacamo RO, Kojima K, Ma MCJ, Ruvolo VR, Chachad D, Devine W, Lindquist S, Davis RE, Porco JA, ... Whitesell L, et al. Inhibition of translation initiation factor eIF4a inactivates heat shock factor 1 (HSF1) and exerts anti-leukemia activity in AML. Leukemia. PMID 34127794 DOI: 10.1038/s41375-021-01308-z  1
2020 Iyer KR, Camara K, Daniel-Ivad M, Trilles R, Pimentel-Elardo SM, Fossen JL, Marchillo K, Liu Z, Singh S, Muñoz JF, Kim SH, Porco JA, Cuomo CA, Williams NS, Ibrahim AS, ... ... Whitesell L, et al. An oxindole efflux inhibitor potentiates azoles and impairs virulence in the fungal pathogen Candida auris. Nature Communications. 11: 6429. PMID 33353950 DOI: 10.1038/s41467-020-20183-3  1
2020 Gaglia G, Rashid R, Yapp C, Joshi GN, Li CG, Lindquist SL, Sarosiek KA, Whitesell L, Sorger PK, Santagata S. HSF1 phase transition mediates stress adaptation and cell fate decisions. Nature Cell Biology. PMID 32015439 DOI: 10.1038/S41556-019-0458-3  1
2019 Jaeger AM, Stopfer L, Lee S, Gaglia G, Sandel D, Santagata S, Lin NU, Trepel JB, White FM, Jacks T, Lindquist S, Whitesell L. Rebalancing protein homeostasis enhances tumor antigen presentation. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 31213460 DOI: 10.1158/1078-0432.Ccr-19-0596  1
2019 Tsvetkov P, Detappe A, Cai K, Keys HR, Brune Z, Ying W, Thiru P, Reidy M, Kugener G, Rossen J, Kocak M, Kory N, Tsherniak A, Santagata S, Whitesell L, et al. Author Correction: Mitochondrial metabolism promotes adaptation to proteotoxic stress. Nature Chemical Biology. PMID 31164776 DOI: 10.1038/S41589-019-0315-5  1
2019 Tsvetkov P, Detappe A, Cai K, Keys HR, Brune Z, Ying W, Thiru P, Reidy M, Kugener G, Rossen J, Kocak M, Kory N, Tsherniak A, Santagata S, Whitesell L, et al. Mitochondrial metabolism promotes adaptation to proteotoxic stress. Nature Chemical Biology. PMID 31133756 DOI: 10.1038/S41589-019-0291-9  1
2019 Whitesell L, Robbins N, Huang DS, McLellan CA, Shekhar-Guturja T, LeBlanc EV, Nation CS, Hui R, Hutchinson A, Collins C, Chatterjee S, Trilles R, Xie JL, Krysan DJ, Lindquist S, et al. Structural basis for species-selective targeting of Hsp90 in a pathogenic fungus. Nature Communications. 10: 402. PMID 30679438 DOI: 10.1038/s41467-018-08248-w  1
2018 Wijeratne EMK, Oliveira MCF, Mafezoli J, Xu YM, Minguzzi S, Batista PHJ, Pessoa ODL, Whitesell L, Gunatilaka AAL. Withaferin A and Withanolide D Analogues with Dual Heat-Shock-Inducing and Cytotoxic Activities: Semisynthesis and Biological Evaluation. Journal of Natural Products. PMID 29537263 DOI: 10.1021/Acs.Jnatprod.7B00918  1
2017 Caraveo G, Soste M, Cappelleti V, Fanning S, van Rossum DB, Whitesell L, Huang Y, Chung CY, Baru V, Zaichick S, Picotti P, Lindquist S. FKBP12 contributes to α-synuclein toxicity by regulating the calcineurin-dependent phosphoproteome. Proceedings of the National Academy of Sciences of the United States of America. PMID 29229832 DOI: 10.1073/pnas.1711926115  1
2017 McLellan CA, Vincent BM, Solis NV, Lancaster AK, Sullivan LB, Hartland CL, Youngsaye W, Filler SG, Whitesell L, Lindquist S. Inhibiting mitochondrial phosphate transport as an unexploited antifungal strategy. Nature Chemical Biology. PMID 29227471 DOI: 10.1038/Nchembio.2534  1
2017 Karras GI, Yi S, Sahni N, Fischer M, Xie J, Vidal M, D'Andrea AD, Whitesell L, Lindquist S. HSP90 Shapes the Consequences of Human Genetic Variation. Cell. PMID 28215707 DOI: 10.1016/J.Cell.2017.01.023  1
2017 Tsvetkov P, Sokol E, Jin D, Gupta P, Santagata S, Whitesell L, Lindquist S. Abstract A28: Targeting the epigenetic state regulating cancer cell vulnerability to proteasome inhibition Clinical Cancer Research. 23. DOI: 10.1158/1557-3265.Pmccavuln16-A28  1
2016 Tsvetkov P, Sokol E, Jin D, Brune Z, Thiru P, Ghandi M, Garraway LA, Gupta PB, Santagata S, Whitesell L, Lindquist S. Suppression of 19S proteasome subunits marks emergence of an altered cell state in diverse cancers. Proceedings of the National Academy of Sciences of the United States of America. PMID 28028240 DOI: 10.1073/Pnas.1619067114  1
2016 Whitesell L, Santagata S. Susan Lindquist (1949-2016). Science (New York, N.Y.). 354: 974. PMID 27884995 DOI: 10.1126/Science.Aal3609  1
2016 Vincent BM, Langlois JB, Srinivas R, Lancaster AK, Scherz-Shouval R, Whitesell L, Tidor B, Buchwald SL, Lindquist S. A Fungal-Selective Cytochrome bc1 Inhibitor Impairs Virulence and Prevents the Evolution of Drug Resistance. Cell Chemical Biology. 23: 978-991. PMID 27524297 DOI: 10.1016/J.Chembiol.2016.06.016  1
2016 Scherz-Shouval R, Mendillo ML, Gaglia G, Ben-Aharon I, Beck AH, Whitesell L, Lindquist S. Abstract PR07: Mechanisms of stromal reprogramming mediated by heat shock factor 1 Cancer Research. 76. DOI: 10.1158/1538-7445.Tme16-Pr07  1
2015 Bagley AF, Scherz-Shouval R, Galie PA, Zhang AQ, Wyckoff J, Whitesell L, Chen CS, Lindquist S, Bhatia SN. Endothelial thermotolerance impairs nanoparticle transport in tumors. Cancer Research. PMID 26122846 DOI: 10.1158/0008-5472.Can-15-0325  1
2015 Davis SA, Vincent BM, Endo MM, Whitesell L, Marchillo K, Andes DR, Lindquist S, Burke MD. Nontoxic antimicrobials that evade drug resistance. Nature Chemical Biology. 11: 481-7. PMID 26030729 DOI: 10.1038/Nchembio.1821  1
2015 Sahni N, Yi S, Taipale M, Fuxman Bass JI, Coulombe-Huntington J, Yang F, Peng J, Weile J, Karras GI, Wang Y, Kovács IA, Kamburov A, Krykbaeva I, Lam MH, Tucker G, ... ... Whitesell LJ, et al. Widespread macromolecular interaction perturbations in human genetic disorders. Cell. 161: 647-60. PMID 25910212 DOI: 10.1016/J.Cell.2015.04.013  1
2014 Whitesell L, Santagata S, Mendillo ML, Lin NU, Proia DA, Lindquist S. HSP90 empowers evolution of resistance to hormonal therapy in human breast cancer models. Proceedings of the National Academy of Sciences of the United States of America. 111: 18297-302. PMID 25489079 DOI: 10.1073/Pnas.1421323111  1
2014 Caraveo G, Auluck PK, Whitesell L, Chung CY, Baru V, Mosharov EV, Yan X, Ben-Johny M, Soste M, Picotti P, Kim H, Caldwell KA, Caldwell GA, Sulzer D, Yue DT, et al. Calcineurin determines toxic versus beneficial responses to α-synuclein. Proceedings of the National Academy of Sciences of the United States of America. 111: E3544-52. PMID 25122673 DOI: 10.1073/Pnas.1413201111  1
2014 Scherz-Shouval R, Santagata S, Mendillo ML, Sholl LM, Ben-Aharon I, Beck AH, Dias-Santagata D, Koeva M, Stemmer SM, Whitesell L, Lindquist S. The reprogramming of tumor stroma by HSF1 is a potent enabler of malignancy. Cell. 158: 564-78. PMID 25083868 DOI: 10.1016/J.Cell.2014.05.045  1
2014 Wijeratne EM, Xu YM, Scherz-Shouval R, Marron MT, Rocha DD, Liu MX, Costa-Lotufo LV, Santagata S, Lindquist S, Whitesell L, Gunatilaka AA. Structure-activity relationships for withanolides as inducers of the cellular heat-shock response. Journal of Medicinal Chemistry. 57: 2851-63. PMID 24625088 DOI: 10.1021/Jm401279N  1
2013 Vincent BM, Lancaster AK, Scherz-Shouval R, Whitesell L, Lindquist S. Fitness trade-offs restrict the evolution of resistance to amphotericin B. Plos Biology. 11: e1001692. PMID 24204207 DOI: 10.1371/Journal.Pbio.1001692  1
2013 Youngsaye W, Hartland CL, Morgan BJ, Ting A, Nag PP, Vincent B, Mosher CA, Bittker JA, Dandapani S, Palmer M, Whitesell L, Lindquist S, Schreiber SL, Munoz B. ML212: A small-molecule probe for investigating fluconazole resistance mechanisms in Candida albicans. Beilstein Journal of Organic Chemistry. 9: 1501-7. PMID 23946849 DOI: 10.3762/Bjoc.9.171  1
2013 Santagata S, Mendillo ML, Tang YC, Subramanian A, Perley CC, Roche SP, Wong B, Narayan R, Kwon H, Koeva M, Amon A, Golub TR, Porco JA, Whitesell L, Lindquist S. Tight coordination of protein translation and HSF1 activation supports the anabolic malignant state. Science (New York, N.Y.). 341: 1238303. PMID 23869022 DOI: 10.1126/Science.1238303  1
2013 Gunaherath GMKB, Marron MT, Wijeratne EMK, Whitesell L, Gunatilaka AAL. Synthesis and biological evaluation of novobiocin analogues as potential heat shock protein 90 inhibitors Bioorganic and Medicinal Chemistry. 21: 5118-5129. PMID 23859777 DOI: 10.1016/J.Bmc.2013.06.042  1
2013 Taipale M, Krykbaeva I, Whitesell L, Santagata S, Zhang J, Liu Q, Gray NS, Lindquist S. Chaperones as thermodynamic sensors of drug-target interactions reveal kinase inhibitor specificities in living cells. Nature Biotechnology. 31: 630-7. PMID 23811600 DOI: 10.1038/Nbt.2620  1
2013 Scherz-Shouval R, Santagata S, Koeva M, Whitesell L, Lindquist S. Abstract A23: Cell autonomous and nonautonomous activities of heat shock factor 1 support tumor initiation, progression, and metastasis Cancer Research. 73. DOI: 10.1158/1538-7445.Tim2013-A23  1
2013 Scherz-Shouval R, Bagley AF, Whitesell L, Bhatia SN, Lindquist S. Abstract C132: Targeting heat shock factor 1 improves the antitumor efficiency of hyperthermia. Molecular Cancer Therapeutics. 12. DOI: 10.1158/1535-7163.Targ-13-C132  1
2013 Lin N, Whitesell L, Gelman R, Mayer E, Krop I, Santagata S, Lowe A, Proia D, Farooq S, Brown M, Iannone M, Lindquist S, Winer E. Abstract OT3-2-05: Randomized phase II study of fulvestrant with or without ganetespib in patients (pts) with hormone receptor (HR)-positive metastatic breast cancer Cancer Research. 73. DOI: 10.1158/0008-5472.Sabcs13-Ot3-2-05  1
2012 Dai C, Santagata S, Tang Z, Shi J, Cao J, Kwon H, Bronson RT, Whitesell L, Lindquist S. Loss of tumor suppressor NF1 activates HSF1 to promote carcinogenesis. The Journal of Clinical Investigation. 122: 3742-54. PMID 22945628 DOI: 10.1172/Jci62727  1
2012 Mendillo ML, Santagata S, Koeva M, Bell GW, Hu R, Tamimi RM, Fraenkel E, Ince TA, Whitesell L, Lindquist S. HSF1 drives a transcriptional program distinct from heat shock to support highly malignant human cancers. Cell. 150: 549-62. PMID 22863008 DOI: 10.1016/J.Cell.2012.06.031  1
2012 Whitesell L, Santagata S, Lin NU. Inhibiting HSP90 to treat cancer: a strategy in evolution. Current Molecular Medicine. 12: 1108-24. PMID 22804235 DOI: 10.2174/156652412803306657  1
2012 McLellan CA, Whitesell L, King OD, Lancaster AK, Mazitschek R, Lindquist S. Inhibiting GPI anchor biosynthesis in fungi stresses the endoplasmic reticulum and enhances immunogenicity. Acs Chemical Biology. 7: 1520-8. PMID 22724584 DOI: 10.1021/Cb300235M  1
2012 Youngsaye W, Dockendorff C, Vincent B, Hartland CL, Bittker JA, Dandapani S, Palmer M, Whitesell L, Lindquist S, Schreiber SL, Munoz B. Overcoming fluconazole resistance in Candida albicans clinical isolates with tetracyclic indoles. Bioorganic & Medicinal Chemistry Letters. 22: 3362-5. PMID 22497765 DOI: 10.1016/J.Bmcl.2012.02.035  1
2012 Wijeratne EM, Bashyal BP, Liu MX, Rocha DD, Gunaherath GM, U'Ren JM, Gunatilaka MK, Arnold AE, Whitesell L, Gunatilaka AA. Geopyxins A-E, ent-kaurane diterpenoids from endolichenic fungal strains Geopyxis aff. majalis and Geopyxis sp. AZ0066: structure-activity relationships of geopyxins and their analogues. Journal of Natural Products. 75: 361-9. PMID 22264149 DOI: 10.1021/Np200769Q  1
2012 Santagata S, Xu YM, Wijeratne EM, Kontnik R, Rooney C, Perley CC, Kwon H, Clardy J, Kesari S, Whitesell L, Lindquist S, Gunatilaka AA. Using the heat-shock response to discover anticancer compounds that target protein homeostasis. Acs Chemical Biology. 7: 340-9. PMID 22050377 DOI: 10.1021/Cb200353M  1
2011 Santagata S, Hu R, Lin NU, Mendillo ML, Collins LC, Hankinson SE, Schnitt SJ, Whitesell L, Tamimi RM, Lindquist S, Ince TA. High levels of nuclear heat-shock factor 1 (HSF1) are associated with poor prognosis in breast cancer. Proceedings of the National Academy of Sciences of the United States of America. 108: 18378-83. PMID 22042860 DOI: 10.1073/Pnas.1115031108  1
2011 Youngsaye W, Vincent B, Hartland CL, Morgan BJ, Buhrlage SJ, Johnston S, Bittker JA, MacPherson L, Dandapani S, Palmer M, Whitesell L, Lindquist S, Schreiber SL, Munoz B. Piperazinyl quinolines as chemosensitizers to increase fluconazole susceptibility of Candida albicans clinical isolates. Bioorganic & Medicinal Chemistry Letters. 21: 5502-5. PMID 21802942 DOI: 10.1016/J.Bmcl.2011.06.105  1
2011 Santagata S, Hu R, Lin N, Mendillo M, Collins L, Hankinson S, Schnitt S, Whitesell L, Lindquist S, Tamimi R, Ince T. P5-01-13: High Levels of Nuclear Heat Shock Factor 1 (HSF1) Are Associated with Poor Prognosis in Breast Cancer: Results from the Nurses' Health Study. Cancer Research. 71. DOI: 10.1158/0008-5472.Sabcs11-P5-01-13  1
2011 Mendillo M, Santagata S, Koeva M, Fraenkel E, Ince T, Whitesell L, Lindquist S. P3-01-09: Oncogenic Activation of HSF1 Enables the Malignant Progression of Breast Carcinoma. Cancer Research. 71. DOI: 10.1158/0008-5472.Sabcs11-P3-01-09  1
2010 Lin N, Beliakoff J, Foley K, Whitesell L, Lindquist S. Abstract P6-15-06: Heat Shock Protein 90 Inhibition Limits the Emergence of Tamoxifen Resistance Cancer Research. 70. DOI: 10.1158/0008-5472.Sabcs10-P6-15-06  1
2009 Whitesell L, Lindquist S. Inhibiting the transcription factor HSF1 as an anticancer strategy Expert Opinion On Therapeutic Targets. 13: 469-478. PMID 19335068 DOI: 10.1517/14728220902832697  1
2009 Cowen LE, Singh SD, Köhler JR, Collins C, Zaas AK, Schell WA, Aziz H, Mylonakis E, Perfect JR, Whitesell L, Lindquist S. Harnessing Hsp90 function as a powerful, broadly effective therapeutic strategy for fungal infectious disease Proceedings of the National Academy of Sciences of the United States of America. 106: 2818-2823. PMID 19196973 DOI: 10.1073/Pnas.0813394106  1
2009 Xu YM, Marron MT, Seddon E, McLaughlin SP, Ray DT, Whitesell L, Gunatilaka AA. 2,3-Dihydrowithaferin A-3beta-O-sulfate, a new potential prodrug of withaferin A from aeroponically grown Withania somnifera. Bioorganic & Medicinal Chemistry. 17: 2210-4. PMID 19056281 DOI: 10.1016/J.Bmc.2008.10.091  1
2008 Hargreaves RH, David CL, Whitesell LJ, Labarbera DV, Jamil A, Chapuis JC, Skibo EB. Discovery of quinolinediones exhibiting a heat shock response and angiogenesis inhibition. Journal of Medicinal Chemistry. 51: 2492-501. PMID 18363347 DOI: 10.1021/Jm7014099  1
2007 Dai C, Whitesell L, Rogers AB, Lindquist S. Heat shock factor 1 is a powerful multifaceted modifier of carcinogenesis. Cell. 130: 1005-18. PMID 17889646 DOI: 10.1016/J.Cell.2007.07.020  1
2007 McLellan CA, Turbyville TJ, Wijeratne EM, Kerschen A, Vierling E, Queitsch C, Whitesell L, Gunatilaka AA. A rhizosphere fungus enhances Arabidopsis thermotolerance through production of an HSP90 inhibitor. Plant Physiology. 145: 174-82. PMID 17631526 DOI: 10.1104/Pp.107.101808  1
2007 Weigel BJ, Blaney SM, Reid JM, Safgren SL, Bagatell R, Kersey J, Neglia JP, Ivy SP, Ingle AM, Whitesell L, Gilbertson RJ, Krailo M, Ames M, Adamson PC. A phase I study of 17-allylaminogeldanamycin in relapsed/refractory pediatric patients with solid tumors: a Children's Oncology Group study. Clinical Cancer Research. 13: 1789-1793. PMID 17363534 DOI: 10.1158/1078-0432.Ccr-06-2270  1
2007 Bagatell R, Gore L, Egorin MJ, Ho R, Heller G, Boucher N, Zuhowski EG, Whitlock JA, Hunger SP, Narendran A, Katzenstein HM, Arceci RJ, Boklan J, Herzog CE, Whitesell L, et al. Phase I pharmacokinetic and pharmacodynamic study of 17-N-allylamino-17-demethoxygeldanamycin in pediatric patients with recurrent or refractory solid tumors: a pediatric oncology experimental therapeutics investigators consortium study. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 13: 1783-8. PMID 17363533 DOI: 10.1158/1078-0432.Ccr-06-1892  1
2006 Wijeratne EM, Turbyville TJ, Fritz A, Whitesell L, Gunatilaka AA. A new dihydroxanthenone from a plant-associated strain of the fungus Chaetomium globosum demonstrates anticancer activity. Bioorganic & Medicinal Chemistry. 14: 7917-23. PMID 16904330 DOI: 10.1016/J.Bmc.2006.07.048  1
2006 Cullinan SB, Whitesell L. Heat shock protein 90: a unique chemotherapeutic target. Seminars in Oncology. 33: 457-65. PMID 16890800 DOI: 10.1053/J.Seminoncol.2006.04.001  1
2006 Turbyville TJ, Wijeratne EM, Liu MX, Burns AM, Seliga CJ, Luevano LA, David CL, Faeth SH, Whitesell L, Gunatilaka AA. Search for Hsp90 inhibitors with potential anticancer activity: isolation and SAR studies of radicicol and monocillin I from two plant-associated fungi of the Sonoran desert. Journal of Natural Products. 69: 178-84. PMID 16499313 DOI: 10.1021/Np058095B  1
2006 Falsey RR, Marron MT, Gunaherath GM, Shirahatti N, Mahadevan D, Gunatilaka AA, Whitesell L. Actin microfilament aggregation induced by withaferin A is mediated by annexin II. Nature Chemical Biology. 2: 33-8. PMID 16408090 DOI: 10.1038/Nchembio755  1
2005 Jeffy BD, Hockings JK, Kemp MQ, Morgan SS, Hager JA, Beliakoff J, Whitesell LJ, Bowden GT, Romagnolo DF. An estrogen receptor-alpha/p300 complex activates the BRCA-1 promoter at an AP-1 site that binds Jun/Fos transcription factors: repressive effects of p53 on BRCA-1 transcription. Neoplasia (New York, N.Y.). 7: 873-82. PMID 16229810 DOI: 10.1593/Neo.05256  1
2005 Turbyville TJ, Wijeratne EM, Whitesell L, Gunatilaka AA. The anticancer activity of the fungal metabolite terrecyclic acid A is associated with modulation of multiple cellular stress response pathways. Molecular Cancer Therapeutics. 4: 1569-76. PMID 16227407 DOI: 10.1158/1535-7163.Mct-05-0050  1
2005 Whitesell L, Lindquist SL. HSP90 and the chaperoning of cancer. Nature Reviews. Cancer. 5: 761-72. PMID 16175177 DOI: 10.1038/nrc1716  1
2005 Devaney E, O'neill K, Harnett W, Whitesell L, Kinnaird JH. Hsp90 is essential in the filarial nematode Brugia pahangi. International Journal For Parasitology. 35: 627-36. PMID 15862576 DOI: 10.1016/J.Ijpara.2005.01.007  0.01
2005 Bagatell R, Beliakoff J, David CL, Marron MT, Whitesell L. Hsp90 inhibitors deplete key anti-apoptotic proteins in pediatric solid tumor cells and demonstrate synergistic anticancer activity with cisplatin International Journal of Cancer. 113: 179-188. PMID 15455381 DOI: 10.1002/Ijc.20611  1
2004 Wijeratne EM, Carbonezi CA, Takahashi JA, Seliga CJ, Turbyville TJ, Pierson EE, Pierson LS, VanEtten HD, Whitesell L, Bolzani Vda S, Gunatilaka AA. Isolation, optimization of production and structure-activity relationship studies of monocillin I, the cytotoxic constituent of Paraphaeosphaeria quadriseptata. The Journal of Antibiotics. 57: 541-6. PMID 15515894 DOI: 10.7164/Antibiotics.57.541  1
2004 Beliakoff J, Whitesell L. Hsp90: an emerging target for breast cancer therapy. Anti-Cancer Drugs. 15: 651-662. PMID 15269596 DOI: 10.1097/01.Cad.0000136876.11928.Be  1
2004 Feng H, Zeng Y, Graner MW, Whitesell L, Katsanis E. Evidence for a Novel, Caspase-8-Independent, Fas Death Domain-Mediated Apoptotic Pathway. Journal of Biomedicine & Biotechnology. 2004: 41-51. PMID 15123887 DOI: 10.1155/S1110724304308041  1
2004 Meade-Tollin LC, Wijeratne EMK, Cooper D, Guild M, Jon E, Fritz A, Zhou GX, Whitesell L, Liang JY, Gunatilaka AAL. Ponicidin and Oridonin Are Responsible for the Antiangiogenic Activity of Rabdosia rubescens, a Constituent of the Herbal Supplement PC SPES Journal of Natural Products. 67: 2-4. PMID 14738375 DOI: 10.1021/Np0304114  1
2003 Wijeratne EM, Turbyville TJ, Zhang Z, Bigelow D, Pierson LS, VanEtten HD, Whitesell L, Canfield LM, Gunatilaka AA. Cytotoxic constituents of Aspergillus terreus from the rhizosphere of Opuntia versicolor of the Sonoran Desert. Journal of Natural Products. 66: 1567-73. PMID 14695798 DOI: 10.1021/Np030266U  1
2003 Whitesell L, Bagatell R, Falsey R. The stress response: implications for the clinical development of hsp90 inhibitors. Current Cancer Drug Targets. 3: 349-358. PMID 14529386 DOI: 10.2174/1568009033481787  1
2003 Hargreaves R, David CL, Whitesell L, Skibo EB. Design of quinolinedione-based geldanamycin analogues. Bioorganic & Medicinal Chemistry Letters. 13: 3075-8. PMID 12941337 DOI: 10.1016/S0960-894X(03)00650-4  1
2003 David CL, Smith HE, Raynes DA, Pulcini EJ, Whitesell L. Expression of a unique drug-resistant Hsp90 ortholog by the nematode Caenorhabditis elegans. Cell Stress & Chaperones. 8: 93-104. PMID 12820659 DOI: 10.1379/1466-1268(2003)8<93:Eoaudh>2.0.Co;2  1
2003 Kobie JJ, Wu RS, Kurt RA, Lou S, Adelman MK, Whitesell LJ, Ramanathapuram LV, Arteaga CL, Akporiaye ET. Transforming growth factor beta inhibits the antigen-presenting functions and antitumor activity of dendritic cell vaccines. Cancer Research. 63: 1860-4. PMID 12702574  1
2002 Bagatell R, Morgan E, Cosentino C, Whitesell L. Two cases of pediatric neuroblastoma with tumor thrombus in the inferior vena cava. Journal of Pediatric Hematology Oncology. 24: 397-400. PMID 12142791 DOI: 10.1097/00043426-200206000-00015  1
2001 Feng H, Zeng Y, Whitesell L, Katsanis E. Stressed apoptotic tumor cells express heat shock proteins and elicit tumor-specific immunity. Blood. 97: 3505-12. PMID 11369644 DOI: 10.1182/Blood.V97.11.3505  1
2001 He L, Feng H, Raymond A, Kreeger M, Zeng Y, Graner M, Whitesell L, Katsanis E. Dendritic-cell-peptide immunization provides immunoprotection against bcr-abl-positive leukemia in mice. Cancer Immunology, Immunotherapy : Cii. 50: 31-40. PMID 11315508 DOI: 10.1007/Pl00006680  1
2001 Bennett CL, Christie J, Ramsdell F, Brunkow ME, Ferguson PJ, Whitesell L, Kelly TE, Saulsbury FT, Chance PF, Ochs HD. The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3. Nature Genetics. 27: 20-21. PMID 11137993 DOI: 10.1038/83713  0.01
2000 Yorgin PD, Hartson SD, Fellah AM, Scroggins BT, Huang W, Katsanis E, Couchman JM, Matts RL, Whitesell L. Effects of geldanamycin, a heat-shock protein 90-binding agent, on T cell function and T cell nonreceptor protein tyrosine kinases. Journal of Immunology (Baltimore, Md. : 1950). 164: 2915-23. PMID 10706677 DOI: 10.4049/Jimmunol.164.6.2915  1
2000 Yorgin PD, Eklund DK, Al-Uzri A, Whitesell L, Theodorou AA. Concurrent centrifugation plasmapheresis and continuous venovenous hemodiafiltration Pediatric Nephrology. 14: 18-21. PMID 10654323 DOI: 10.1007/S004670050004  1
1999 Whitesell L, Liu X, Bagatell R. Inhibition of Oncogene Expression Using Vector-Generated RNA Antisense Methods. 18: 296-303. PMID 10454988 DOI: 10.1006/Meth.1999.0787  1
1999 Lele Z, Hartson SD, Martin CC, Whitesell L, Matts RL, Krone PH. Disruption of zebrafish somite development by pharmacologic inhibition of Hsp90 Developmental Biology. 210: 56-70. PMID 10364427 DOI: 10.1006/Dbio.1999.9262  1
1999 Hartson SD, Thulasiraman V, Huang W, Whitesell L, Matts RL. Molybdate inhibits hsp90, induces structural changes in its C-terminal domain, and alters its interactions with substrates. Biochemistry. 38: 3837-49. PMID 10090774 DOI: 10.1021/Bi983027S  1
1998 Slepian MJ, Massia SP, Dehdashti B, Fritz A, Whitesell L. β3-Integrins rather than β1-integrins dominate integrin-matrix interactions involved in postinjury smooth muscle cell migration Circulation. 97: 1818-1827. PMID 9603537 DOI: 10.1161/01.Cir.97.18.1818  1
1998 Whitesell L, Sutphin PD, Pulcini EJ, Martinez JD, Cook PH. The physical association of multiple molecular chaperone proteins with mutant p53 is altered by geldanamycin, an hsp90-binding agent. Molecular and Cellular Biology. 18: 1517-24. PMID 9488468 DOI: 10.1128/Mcb.18.3.1517  0.04
1997 Whitesell L, Sutphin P, An WG, Schulte T, Blagosklonny MV, Neckers L. Geldanamycin-stimulated destabilization of mutated p53 is mediated by the proteasome in vivo. Oncogene. 14: 2809-2816. PMID 9190897 DOI: 10.1038/Sj.Onc.1201120  0.01
1996 Whitesell L, Cook P. Stable and Specific Binding of Heat Shock Protein 90 by Geldanamycin Disrupts Glucocorticoid Receptor Function in Intact Cells Molecular Endocrinology. 10: 705-712. PMID 8776730 DOI: 10.1210/Mend.10.6.8776730  0.01
1996 Slepian MJ, Massia SP, Whitesell L. Pre-conditioning of smooth muscle cells via induction of the heat shock response limits proliferation following mechanical injury Biochemical and Biophysical Research Communications. 225: 600-607. PMID 8753806 DOI: 10.1006/Bbrc.1996.1217  1
1996 Sei Y, Whitesell L, Kustova Y, Paul IA, Morse HC, Skolnick P, Basile AS. Altered brain fyn kinase in a murine acquired immunodeficiency syndrome. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 10: 339-44. PMID 8641568 DOI: 10.1096/Fasebj.10.2.8641568  1
1996 Chavany C, Mimnaugh E, Miller P, Bitton R, Nguyen P, Trepel J, Whitesell L, Schnur R, Moyer JD, Neckers L. p185 Binds to GRP94 in Vivo DISSOCIATION OF THE p185/GRP94 HETEROCOMPLEX BY BENZOQUINONE ANSAMYCINS PRECEDES DEPLETION OF p185 Journal of Biological Chemistry. 271: 4974-4977. PMID 8617772 DOI: 10.1074/Jbc.271.9.4974  0.01
1995 Mimnaugh EG, Worland PJ, Whitesell L, Neckers LM. Possible role for serine/threonine phosphorylation in the regulation of the heteroprotein complex between the hsp90 stress protein and the pp60v-src tyrosine kinase. Journal of Biological Chemistry. 270: 28654-28659. PMID 7499384 DOI: 10.1074/Jbc.270.48.28654  0.01
1994 Bang YJ, Pirnia F, Fang WG, Kang WK, Sartor O, Whitesell L, Ha MJ, Tsokos M, Sheahan MD, Nguyen P, Niklinski WT, Myers CE, Trepel JB. Terminal neuroendocrine differentiation of human prostate carcinoma cells in response to increased intracellular cyclic AMP Proceedings of the National Academy of Sciences of the United States of America. 91: 5330-5334. PMID 8202489 DOI: 10.1073/pnas.91.12.5330  1
1993 Whitesell L, Geselowitz D, Chavany C, Fahmy B, Walbridge S, Alger JR, Neckers LM. Stability, clearance, and disposition of intraventricularly administered oligodeoxynucleotides: implications for therapeutic application within the central nervous system. Proceedings of the National Academy of Sciences of the United States of America. 90: 4665-9. PMID 8506315 DOI: 10.1073/Pnas.90.10.4665  1
1992 Neckers LM, Rosolen A, Whitesell L. Antisense inhibition of gene expression: a tool for studying the role of NMYC in the growth and differentiation of neuroectoderm-derived cells. Journal of Immunotherapy. 12: 162-166. PMID 1332744 DOI: 10.1097/00002371-199210000-00003  0.04
1991 Whitesell L, Rosolen A, Neckers L. Episome-generated N-myc antisense RNA restricts the differentiation potential of primitive neuroectodermal cell lines. Molecular and Cellular Biology. 11: 1360-1371. PMID 1996098 DOI: 10.1128/Mcb.11.3.1360  0.01
1991 Whitesell L, Rosolen A, Neckers LM. In Vivo Modulation of N-myc Expression by Continuous Perfusion with an Antisense Oligonucleotide Antisense Research and Development. 1: 343-350. PMID 1821655 DOI: 10.1089/Ard.1991.1.343  0.01
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