Simeon I. Taylor - Publications

Affiliations: 
The George Washington University, Washington, DC, United States 
 2013- University of Maryland School of Medicine, Baltimore, MD, United States 
Area:
Molecular Biology, Genetics, Entomology Biology
Website:
http://www.medschool.umaryland.edu/profiles/Taylor-Simeon/

138 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2003 Shi Y, Taylor SI, Tan SL, Sonenberg N. When translation meets metabolism: multiple links to diabetes. Endocrine Reviews. 24: 91-101. PMID 12588811 DOI: 10.1210/Er.2002-0018  1
2002 Petersen KF, Oral EA, Dufour S, Befroy D, Ariyan C, Yu C, Cline GW, DePaoli AM, Taylor SI, Gorden P, Shulman GI. Leptin reverses insulin resistance and hepatic steatosis in patients with severe lipodystrophy. The Journal of Clinical Investigation. 109: 1345-50. PMID 12021250 DOI: 10.1172/Jci15001  1
2002 Agarwal AK, Arioglu E, De Almeida S, Akkoc N, Taylor SI, Bowcock AM, Barnes RI, Garg A. AGPAT2 is mutated in congenital generalized lipodystrophy linked to chromosome 9q34. Nature Genetics. 31: 21-3. PMID 11967537 DOI: 10.1038/Ng880  1
2002 Arioglu E, Andewelt A, Diabo C, Bell M, Taylor SI, Gorden P. Clinical course of the syndrome of autoantibodies to the insulin receptor (type B insulin resistance): a 28-year perspective. Medicine. 81: 87-100. PMID 11889410 DOI: 10.1097/00005792-200203000-00001  1
2002 Oral EA, Simha V, Ruiz E, Andewelt A, Premkumar A, Snell P, Wagner AJ, DePaoli AM, Reitman ML, Taylor SI, Gorden P, Garg A. Leptin-replacement therapy for lipodystrophy. The New England Journal of Medicine. 346: 570-8. PMID 11856796 DOI: 10.1056/Nejmoa012437  1
2002 Faletti CJ, Perrotti N, Taylor SI, Blazer-Yost BL. sgk: an essential convergence point for peptide and steroid hormone regulation of ENaC-mediated Na+ transport. American Journal of Physiology. Cell Physiology. 282: C494-500. PMID 11832334 DOI: 10.1152/Ajpcell.00408.2001  1
2002 Bolan C, Oral EA, Gorden P, Taylor S, Leitman SF. Intensive, long-term plasma exchange therapy for severe hypertriglyceridemia in acquired generalized lipoatrophy. The Journal of Clinical Endocrinology and Metabolism. 87: 380-4. PMID 11788680 DOI: 10.1210/Jcem.87.1.8176  1
2002 Berger JR, Oral EA, Taylor SI. Familial lipodystrophy associated with neurodegeneration and congenital cataracts. Neurology. 58: 43-7. PMID 11781404 DOI: 10.1212/Wnl.58.1.43  1
2001 Jacobs AR, LeRoith D, Taylor SI. Insulin receptor substrate-1 pleckstrin homology and phosphotyrosine-binding domains are both involved in plasma membrane targeting. The Journal of Biological Chemistry. 276: 40795-802. PMID 11526109 DOI: 10.1074/Jbc.M105194200  1
2001 Parks WT, Frank DB, Huff C, Renfrew Haft C, Martin J, Meng X, de Caestecker MP, McNally JG, Reddi A, Taylor SI, Roberts AB, Wang T, Lechleider RJ. Sorting nexin 6, a novel SNX, interacts with the transforming growth factor-beta family of receptor serine-threonine kinases. The Journal of Biological Chemistry. 276: 19332-9. PMID 11279102 DOI: 10.1074/Jbc.M100606200  1
2001 Perrotti N, He RA, Phillips SA, Haft CR, Taylor SI. Activation of Serum- and Glucocorticoid-induced Protein Kinase (Sgk) by Cyclic AMP and Insulin Journal of Biological Chemistry. 276: 9406-9412. DOI: 10.1074/jbc.M007052200  1
2001 Phillips SA, Barr VA, Haft DH, Taylor SI, Haft CR. Identification and Characterization of SNX15, a Novel Sorting Nexin Involved in Protein Trafficking Journal of Biological Chemistry. 276: 5074-5084. DOI: 10.1074/jbc.M004671200  1
2000 Haft CR, De la Luz Sierra M, Bafford R, Lesniak MA, Barr VA, Taylor SI. Human orthologs of yeast vacuolar protein sorting proteins Vps26, 29, and 35: Assembly into multimeric complexes Molecular Biology of the Cell. 11: 4105-4116. PMID 11102511 DOI: 10.1091/Mbc.11.12.4105  1
2000 Reitman ML, Arioglu E, Gavrilova O, Taylor SI. Lipoatrophy revisited. Trends in Endocrinology and Metabolism: Tem. 11: 410-6. PMID 11091118 DOI: 10.1016/S1043-2760(00)00309-X  1
2000 Kubota N, Tobe K, Terauchi Y, Eto K, Yamauchi T, Suzuki R, Tsubamoto Y, Komeda K, Nakano R, Miki H, Satoh S, Sekihara H, Sciacchitano S, Lesniak M, Aizawa S, ... ... Taylor SI, et al. Disruption of insulin receptor substrate 2 causes type 2 diabetes because of liver insulin resistance and lack of compensatory β-cell hyperplasia Diabetes. 49: 1880-1889. PMID 11078455 DOI: 10.2337/Diabetes.49.11.1880  1
2000 Arioglu E, Duncan-Morin J, Sebring N, Rother KI, Gottlieb N, Lieberman J, Herion D, Kleiner DE, Reynolds J, Premkumar A, Sumner AE, Hoofnagle J, Reitman ML, Taylor SI. Efficacy and safety of troglitazone in the treatment of lipodystrophy syndromes. Annals of Internal Medicine. 133: 263-74. PMID 10929166 DOI: 10.7326/0003-4819-133-4-200008150-00009  1
2000 Poltilove RM, Jacobs AR, Haft CR, Xu P, Taylor SI. Characterization of Drosophila insulin receptor substrate. The Journal of Biological Chemistry. 275: 23346-54. PMID 10801879 DOI: 10.1074/jbc.M003579200  1
2000 Speckman RA, Garg A, Du F, Bennett L, Veile R, Arioglu E, Taylor SI, Lovett M, Bowcock AM. Mutational and haplotype analyses of families with familial partial lipodystrophy (Dunnigan variety) reveal recurrent missense mutations in the globular C-terminal domain of lamin A/C. American Journal of Human Genetics. 66: 1192-8. PMID 10739751 DOI: 10.1086/302836  1
2000 Taylor SI. Rational design of peptide agonists of cell-surface receptors Trends in Pharmacological Sciences. 21: 9-10. PMID 10637647 DOI: 10.1016/S0165-6147(99)01414-5  1
1999 Taylor SI, Arioglu E. Genetically defined forms of diabetes in children. The Journal of Clinical Endocrinology and Metabolism. 84: 4390-6. PMID 10599693 DOI: 10.1210/Jcem.84.12.6237  1
1999 Garg A, Wilson R, Barnes R, Arioglu E, Zaidi Z, Gurakan F, Kocak N, O'Rahilly S, Taylor SI, Patel SB, Bowcock AM. A gene for congenital generalized lipodystrophy maps to human chromosome 9q34. The Journal of Clinical Endocrinology and Metabolism. 84: 3390-4. PMID 10487716 DOI: 10.1210/Jcem.84.9.6103  1
1999 Barr VA, Lane K, Taylor SI. Subcellular localization and internalization of the four human leptin receptor isoforms Journal of Biological Chemistry. 274: 21416-21424. PMID 10409704 DOI: 10.1074/Jbc.274.30.21416  1
1999 Xu P, Jacobs AR, Taylor SI. Interaction of insulin receptor substrate 3 with insulin receptor, insulin receptor-related receptor, insulin-like growth factor-1 receptor, and downstream signaling proteins. The Journal of Biological Chemistry. 274: 15262-70. PMID 10329736 DOI: 10.1074/Jbc.274.21.15262  1
1999 Taylor SI. Deconstructing type 2 diabetes Cell. 97: 9-12. PMID 10199397 DOI: 10.1016/S0092-8674(00)80709-6  1
1999 Zhou L, Chen H, Xu P, Cong LN, Sciacchitano S, Li Y, Graham D, Jacobs AR, Taylor SI, Quon MJ. Action of insulin receptor substrate-3 (IRS-3) and IRS-4 to stimulate translocation of GLUT4 in rat adipose cells. Molecular Endocrinology (Baltimore, Md.). 13: 505-14. PMID 10077007 DOI: 10.1210/Mend.13.3.0242  1
1998 Taylor SI, Arioglu E. Syndromes associated with insulin resistance and acanthosis nigricans. Journal of Basic and Clinical Physiology and Pharmacology. 9: 419-39. PMID 10212846 DOI: 10.1515/Jbcpp.1998.9.2-4.419  1
1998 Haft CR, De La Luz Sierra M, Barr VA, Haft DH, Taylor SI. Identification of a family of sorting nexin molecules and characterization of their association with receptors Molecular and Cellular Biology. 18: 7278-7287. PMID 9819414 DOI: 10.1128/Mcb.18.12.7278  1
1998 Wertheimer E, Taylor SI, Tennenbaum T. Insulin receptor regulation of cell surface integrins: A possible mechanism contributing to the development of diabetic complications Proceedings of the Association of American Physicians. 110: 333-339. PMID 9686681  1
1998 Haft CR, De La Luz Sierra M, Hamer I, Carpentier JL, Taylor SI. Analysis of the juxtamembrane dileucine motif in the insulin receptor Endocrinology. 139: 1618-1629. PMID 9528942 DOI: 10.1210/Endo.139.4.5939  1
1998 Taylor SI. Chapter 15 Molecular mechanisms in the pathophysiology of noninsulin-dependent diabetes mellitus: Insulin resistance and insulin deficiency Principles of Medical Biology. 10: 365-386. DOI: 10.1016/S1569-2582(97)80160-2  1
1997 Cong LN, Chen H, Li Y, Zhou L, McGibbon MA, Taylor SI, Quon MJ. Physiological role of AKT in insulin-stimulated translocation of GLUT4 in transfected rat adipose cells Molecular Endocrinology. 11: 1881-1890. PMID 9415393 DOI: 10.1210/Mend.11.13.0027  1
1997 Imai Y, Philippe N, Sesti G, Accili D, Taylor SI. Expression of variant forms of insulin receptor substrate-1 identified in patients with noninsulin-dependent diabetes mellitus Journal of Clinical Endocrinology and Metabolism. 82: 4201-4207. PMID 9398740 DOI: 10.1210/Jcem.82.12.4429  1
1997 Zhou L, Chen H, Lin CH, Cong LN, McGibbon MA, Sciacchitano S, Lesniak MA, Quon MJ, Taylor SI. Insulin receptor substrate-2 (IRS-2) can mediate the action of insulin of stimulate translocation of GLUT4 to the cell surface in rat adipose cells Journal of Biological Chemistry. 272: 29829-29833. PMID 9368055 DOI: 10.1074/Jbc.272.47.29829  1
1997 Sciacchitano S, Taylor SI. Cloning, tissue expression, and chromosomal localization of the mouse IRS-3 gene Endocrinology. 138: 4931-4940. PMID 9348224 DOI: 10.1210/Endo.138.11.5518  1
1997 Silver K, Walston J, Plotnick L, Taylor SI, Kahn CR, Shuldiner AR. Molecular scanning of β-3-adrenergic receptor gene in total congenital lipoatrophic diabetes mellitus Journal of Clinical Endocrinology and Metabolism. 82: 3395-3398. PMID 9329375 DOI: 10.1210/Jcem.82.10.4314  1
1997 Barr VA, Malide D, Zarnowski MJ, Taylor SI, Cushman SW. Insulin stimulates both leptin secretion and production by rat white adipose tissue Endocrinology. 138: 4463-4472. PMID 9322964 DOI: 10.1210/Endo.138.10.5451  1
1997 Kadowaki H, Takahashi Y, Ando A, Momomura K, Kaburagi Y, Quin JD, MacCuish AC, Koda N, Fukushima Y, Taylor SI, Akanuma Y, Yazaki Y, Kadowaki T. Four mutant alleles of the insulin receptor gene associated with genetic syndromes of extreme insulin resistance Biochemical and Biophysical Research Communications. 237: 516-520. PMID 9299395 DOI: 10.1006/Bbrc.1997.7181  1
1997 Hamer I, Haft CR, Paccaud JP, Maeder C, Taylor S, Carpentier JL. Dual role of a dileucine motif in insulin receptor endocytosis. The Journal of Biological Chemistry. 272: 21685-91. PMID 9268295 DOI: 10.1074/Jbc.272.35.21685  1
1997 Brüning JC, Winnay J, Bonner-Weir S, Taylor SI, Accili D, Kahn CR. Development of a novel polygenic model of NIDDM in mice heterozygous for IR and IRS-1 null alleles Cell. 88: 561-572. PMID 9038347 DOI: 10.1016/S0092-8674(00)81896-6  1
1996 Taylor SI, Barr V, Reitman M. Does leptin contribute to diabetes caused by obesity? Science. 274: 1151-1152. PMID 8966588 DOI: 10.1126/Science.274.5290.1151  1
1996 Taouis M, Taylor SI, Reitman M. Cloning of the chicken insulin receptor substrate 1 gene Gene. 178: 51-55. PMID 8921891 DOI: 10.1016/0378-1119(96)00333-2  1
1996 Jui HY, Accili D, Taylor SI. Characterization of a hybrid receptor formed by dimerization of the insulin receptor-related receptor (IRR) with the insulin receptor (IR): Coexpression of cDNAs encoding human IRR and human IR in NIH-3T3 cells Biochemistry. 35: 14326-14330. PMID 8916919 DOI: 10.1021/Bi9613032  1
1996 Quon MJ, Chen H, Lin CH, Zhou L, Ing BL, Zarnowski MJ, Klinghoffer R, Kazlauskas A, Cushman SW, Taylor SI. Effects of overexpressing wild-type and mutant PDGF receptors on translocation of GLUT4 in transfected rat adipose cells. Biochemical and Biophysical Research Communications. 226: 587-94. PMID 8831662 DOI: 10.1006/Bbrc.1996.1400  1
1996 Accili D, Drago J, Lee EJ, Johnson MD, Cool MH, Salvatore P, Asico LD, Jose PA, Taylor SI, Westphal H. Early neonatal death in mice homozygous for a null allele of the insulin receptor gene Nature Genetics. 12: 106-109. PMID 8528241 DOI: 10.1038/Ng0196-106  1
1995 Levy-Toledano R, Blaettler DH, Larochelle WJ, Taylor SI. Insulin-induced activation of phosphatidylinositol (PI) 3-kinase: Insulin-induced phosphorylation of insulin receptors and insulin receptor substrate-1 displaces phosphorylated platelet-derived growth factor receptors from binding sites on PI 3-kinase Journal of Biological Chemistry. 270: 30018-30022. PMID 8530404 DOI: 10.1074/Jbc.270.50.30018  1
1995 Cama A, de la Luz Sierra M, Kadowaki T, Kadowaki H, Quon MJ, Rüdiger HW, Dreyer M, Taylor SI. Two mutant alleles of the insulin receptor gene in a family with a genetic form of insulin resistance: a 10 base pair deletion in exon 1 and a mutation substituting serine for asparagine-462 Human Genetics. 95: 174-182. PMID 7860063 DOI: 10.1007/Bf00209397  1
1995 Suzuki Y, Hatanaka Y, Taira M, Shimada F, Hashimoto N, Takayanagi M, Taylor SI, Makino H, Yoshida S. Insulin resistance associated with decreased levels of insulin-receptor messenger ribonucleic acid: evidence of a de novo mutation in the maternal allele. The Journal of Clinical Endocrinology and Metabolism. 80: 1214-20. PMID 7714091 DOI: 10.1210/jcem.80.4.7714091  1
1995 Voliovitch H, Schindler DG, Hadari YR, Taylor SI, Accili D, Zick Y. Tyrosine phosphorylation of insulin receptor substrate-1 in vivo depends upon the presence of its pleckstrin homology region. The Journal of Biological Chemistry. 270: 18083-7. PMID 7629118 DOI: 10.1074/Jbc.270.30.18083  1
1995 Najjar SM, Philippe N, Suzuki Y, Ignacio GA, Formisano P, Accili D, Taylor SI. Insulin-stimulated phosphorylation of recombinant pp120/HA4, an endogenous substrate of the insulin receptor tyrosine kinase. Biochemistry. 34: 9341-9. PMID 7626603 DOI: 10.1021/Bi00029A009  1
1995 Quon MJ, Chen H, Ing BL, Liu ML, Zarnowski MJ, Yonezawa K, Kasuga M, Cushman SW, Taylor SI. Roles of 1-phosphatidylinositol 3-kinase and ras in regulating translocation of GLUT4 in transfected rat adipose cells Molecular and Cellular Biology. 15: 5403-5411. PMID 7565691 DOI: 10.1128/Mcb.15.10.5403  1
1995 Hone J, Accili D, Psiachou H, Alghband‐Zadeh J, Mitton S, Wertheimer E, Sinclair L, Taylor SI. Homozygosity for a null allele of the insulin receptor gene in a patient with leprechaunism Human Mutation. 6: 17-22. PMID 7550226 DOI: 10.1002/Humu.1380060105  1
1995 Taylor SI. Editorial: Prenatal screening for mutations in the insulin receptor gene. How reliably does genotype predict phenotype? Journal of Clinical Endocrinology and Metabolism. 80: 1493-1495. PMID 7538142 DOI: 10.1210/jcem.80.5.7538142  1
1994 Quon MJ, Guerre-Millo M, Zarnowski MJ, Butte AJ, Em M, Cushman SW, Taylor SI. Tyrosine kinase-deficient mutant human insulin receptors (Met1153 → Ile) overexpressed in transfected rat adipose cells fail to mediate translocation of epitope-tagged GLUT4 Proceedings of the National Academy of Sciences of the United States of America. 91: 5587-5591. PMID 8202531 DOI: 10.1073/Pnas.91.12.5587  1
1994 Taouis M, Levy-Toledano R, Roach P, Taylor SI, Gorden P. Structural basis by which a recessive mutation in the α-subunit of the insulin receptor affects insulin binding Journal of Biological Chemistry. 269: 14912-14918. PMID 8195122  1
1994 Taylor SI, Accili D, Imai Y. Insulin resistance or insulin deficiency: Which is the primary cause of NIDDM? Diabetes. 43: 735-740. PMID 8194657 DOI: 10.2337/Diab.43.6.735  1
1994 Wertheimer E, Litvin Y, Ebstein RP, Bennet ER, Barbetti F, Accili D, Taylor SI. Deletion of exon 3 of the insulin receptor gene in a kindred with a familial form of insulin resistance. The Journal of Clinical Endocrinology and Metabolism. 78: 1153-8. PMID 8175972 DOI: 10.1210/Jcem.78.5.8175972  1
1994 Accili D, Mosthaf L, Levy-Toledano R, Ullrich A, Taylor SI. Mutagenesis of Phe381 and Phe382 in the extracellular domain of the insulin receptor: effects on receptor biosynthesis, processing, and ligand-dependent internalization Febs Letters. 341: 104-108. PMID 8137907 DOI: 10.1016/0014-5793(94)80249-1  1
1994 Wertheimer E, Barbetti F, Muggeo M, Roth J, Taylor SI. Two mutations in a conserved structural motif in the insulin receptor inhibit normal folding and intracellular transport of the receptor Journal of Biological Chemistry. 269: 7587-7592. PMID 8125981  1
1994 Levy-Toledano R, Caro LHP, Accili D, Taylor SI. Investigation of the mechanism of the dominant negative effect of mutations in the tyrosine kinase domain of the insulin receptor Embo Journal. 13: 835-842. PMID 8112298 DOI: 10.1002/J.1460-2075.1994.Tb06326.X  1
1994 Jui HY, Suzuki Y, Accili D, Taylor SI. Expression of a cDNA encoding the human insulin receptor-related receptor Journal of Biological Chemistry. 269: 22446-22452. PMID 8071374  1
1994 Roach P, Zick Y, Formisano P, Accili D, Taylor SI, Gorden P. A novel human insulin receptor gene mutation uniquely inhibits insulin binding without impairing posttranslational processing Diabetes. 43: 1096-1102. PMID 8070609 DOI: 10.2337/Diab.43.9.1096  1
1994 Haft CR, Taylor SI. Deletion of 343 amino acids from the carboxyl terminus of the β-subunit of the insulin receptor inhibits insulin signaling Biochemistry. 33: 9143-9151. PMID 8049217 DOI: 10.1021/Bi00197A017  1
1994 Quon MJ, Cochran C, Taylor SI, Eastman RC. Non-insulin-mediated glucose disappearance in subjects with IDDM: Discordance between experimental results and minimal model analysis Diabetes. 43: 890-896. PMID 8013753  1
1994 Chen H, Walker GE, Taylor SI, McKeon C. Proximal enhancer of the human insulin receptor gene binds the transcription factor Sp1 Diabetes. 43: 884-889. PMID 8013752 DOI: 10.2337/Diab.43.7.884  1
1994 Sorbara LR, Zhichun Tang, Cama A, Jinru Xia, Schenker E, Kohanski RA, Poretsky L, Koller E, Taylor SI, Dunaif A. Absence of insulin receptor gene mutations in three insulin-resistant women with the polycystic ovary syndrome Metabolism. 43: 1568-1574. PMID 7990713 DOI: 10.1016/0026-0495(94)90018-3  1
1994 Imai Y, Fusco A, Suzuki Y, Lesniak MA, D'Alfonso R, Sesti G, Bertoli A, Lauro R, Accili D, Taylor SI. Variant sequences of insulin receptor substrate-1 in patients with noninsulin-dependent diabetes mellitus Journal of Clinical Endocrinology and Metabolism. 79: 1655-1658. PMID 7989470 DOI: 10.1210/Jcem.79.6.7989470  1
1994 Levy-Toledano R, Taouis M, Blaettler DH, Gorden P, Taylor SI. Insulin-induced activation of phosphatidyl inositol 3-kinase. Demonstration that the p85 subunit binds directly to the COOH terminus of the insulin receptor in intact cells Journal of Biological Chemistry. 269: 31178-31182. PMID 7983060  1
1994 Taylor SI, Accili D, Haft CR, Hone J, Imai Y, Levy-Toledano R, Quon MJ, Suzuki Y, Wertheimer E. Mechanisms of hormone resistance: lessons from insulin-resistant patients Acta Paediatrica (Oslo, Norway : 1992). Supplement. 399: 95-104. PMID 7949626 DOI: 10.1111/J.1651-2227.1994.Tb13300.X  1
1994 Haft CR, Klausner RD, Taylor SI. Involvement of dileucine motifs in the internalization and degradation of the insulin receptor. The Journal of Biological Chemistry. 269: 26286-94. PMID 7929346  1
1994 Hone J, Accili D, Al-Gazali LI, Lestringant G, Orban T, Taylor SI. Homozygosity for a new mutation (Ile119 → Met) in the insulin receptor gene in five sibs with familial insulin resistance Journal of Medical Genetics. 31: 715-716. PMID 7815442  1
1994 Quon MJ, Cochran C, Taylor SI, Eastman RC. Direct comparison of standard and insulin modified protocols for minimal model estimation of insulin sensitivity in normal subjects Diabetes Research (Edinburgh, Lothian). 25: 139-149. PMID 7648784  1
1994 Quon MJ, Butte AJ, Zarnowski MJ, Sesti G, Cushman SW, Taylor SI. Insulin receptor substrate 1 mediates the stimulatory effect of insulin on GLUT4 translocation in transfected rat adipose cells Journal of Biological Chemistry. 269: 27920-27924. PMID 7525563  1
1994 Taouis M, Levy-Toledano R, Roach P, Taylor SI, Gorden P. Rescue and activation of a binding-deficient insulin receptor: Evidence for intermolecular transphosphorylation Journal of Biological Chemistry. 269: 27762-27766. PMID 7525562  1
1994 Quon MJ, Butte AJ, Taylor SI. Insulin signal transduction pathways Trends in Endocrinology and Metabolism. 5: 369-376. DOI: 10.1016/1043-2760(94)90104-X  1
1993 Levy-Toledano R, Caro LHP, Hindman N, Taylor SI. Streptavidin blotting: A sensitive technique to study cell surface proteins; Application to investigate autophosphorylation and endocytosis of biotin-labeled insulin receptors Endocrinology. 133: 1803-1808. PMID 8404622 DOI: 10.1210/Endo.133.4.8404622  1
1993 Quon MJ, Zarnowski MJ, Guerremillo M, Sierra MD, Taylor SI, Cushman SW. Transfection of DNA into Isolated Rat Adipose Cells by Electroporation:. Evaluation of Promoter Activity in Transfected Adipose Cells Which Are Highly Responsive to Insulin after 1 Day in Culture Biochemical and Biophysical Research Communications. 194: 338-346. PMID 8392839 DOI: 10.1006/Bbrc.1993.1825  1
1993 Najjar SM, Accili D, Philippe N, Jernberg J, Margolis R, Taylor SI. pp120/ecto-ATPase, an endogenous substrate of the insulin receptor tyrosine kinase, is expressed as two variably spliced isoforms Journal of Biological Chemistry. 268: 1201-1206. PMID 8380406  1
1993 Collier E, Carpentier JL, Beitz L, Carol H, Taylor SI, Gorden P. Specific glycosylation site mutations of the insulin receptor alpha subunit impair intracellular transport. Biochemistry. 32: 7818-23. PMID 8347587  1
1993 Levy-Toledano R, Accili D, Taylor SI. Deletion of C-terminal 113 amino acids impairs processing and internalization of human insulin receptor: Comparison of receptors expressed in CHO and NIH-3T3 cells Bba - Molecular Cell Research. 1220: 1-14. PMID 8268238 DOI: 10.1016/0167-4889(93)90090-C  1
1993 Carrera P, Cordera R, Ferrarl M, Cremonesl L, Taramelli R, Andraghettl G, Carduccl C, Dozio N, Pozza G, Taylor SI, Mlcossl P, Barbettl F. Substitution of leu for pro-193 in the insulin receptor in a patient with a genetic form of severe insulin resistance Human Molecular Genetics. 2: 1437-1441. PMID 8242067 DOI: 10.1093/hmg/2.9.1437  1
1993 Najjar SM, Philippe N, Taylor SI, Accili D. Molecular cloning of pp120/ ecto-ATPase, an endogenous substrate of the insulin receptor kinase Advances in Experimental Medicine and Biology. 343: 169-174. PMID 8184737 DOI: 10.1007/978-1-4615-2988-0_17  1
1993 Cama A, De la Luz Sierra M, Quon MJ, Ottini L, Gorden P, Taylor SI. Substitution of glutamic acid for alanine 1135 in the putative 'catalytic loop' of the tyrosine kinase domain of the human insulin receptor. A mutation that impairs proteolytic processing into subunits and inhibits receptor tyrosine kinase activity Journal of Biological Chemistry. 268: 8060-8069. PMID 8096518  1
1993 Wertheimer E, Lu SP, Backeljauw PF, Davenport ML, Taylor SI. Homozygous deletion of the human insulin receptor gene results in leprechaunism Nature Genetics. 5: 71-73. PMID 7693131 DOI: 10.1038/Ng0993-71  1
1993 Kato H, Faria TN, Stannard B, Levy-Toledano R, Taylor SI, Roberts CT, LeRoith D. Paradoxical biological effects of overexpressed insulin-Like growth factor-1 receptors in Chinese hamster ovary cells Journal of Cellular Physiology. 156: 145-152. PMID 7686165 DOI: 10.1002/Jcp.1041560120  1
1992 Accili D, Kadowaki T, Kadowaki H, Mosthaf L, Ullrich A, Taylor SI. Immunoglobulin heavy chain-binding protein binds to misfolded mutant insulin receptors with mutations in the extracellular domain Journal of Biological Chemistry. 267: 586-590. PMID 1730618  1
1992 Barbetti F, Gejman PV, Taylor SI, Raben N, Cama A, Bonora E, Pizzo P, Moghetti P, Muggeo M, Roth J. Detection of mutations in insulin receptor gene by denaturing gradient gel electrophoresis. Diabetes. 41: 408-15. PMID 1607067 DOI: 10.2337/Diab.41.4.408  1
1992 Accili D, Barbetti F, Cama A, Kadowaki H, Kadowaki T, Imano E, Levy-Toledano R, Taylor SI. Mutations in the insulin receptor gene in patients with genetic syndromes of insulin resistance and acanthosis nigricans Journal of Investigative Dermatology. 98. PMID 1588128 DOI: 10.1111/1523-1747.Ep12462281  1
1992 Kim H, Kadowaki H, Sakura H, Odawara M, Momomura K, Takahashi Y, Miyazaki Y, Ohtani T, Akanuma Y, Yazaki Y, Kasuga M, Taylor SI, Kadowaki T. Detection of mutations in the insulin receptor gene in patients with insulin resistance by analysis of single-stranded conformational polymorphisms Diabetologia. 35: 261-266. PMID 1563582 DOI: 10.1007/Bf00400927  1
1992 Taylor SI. Editorial: The hunt for mutations causing noninsulin-dependent diabetes mellitus Journal of Clinical Endocrinology and Metabolism. 75: 1401-1403. PMID 1464639 DOI: 10.1210/jcem.75.6.1464639  1
1992 Quon MJ, Cama A, Taylor SI. Postbinding characterization of five naturally occurring mutations in the human insulin receptor gene: Impaired insulin-stimulated c-jun expression and thymidine incorporation Despite normal receptor autophosphorylation Biochemistry. 31: 9947-9954. PMID 1390778 DOI: 10.1021/Bi00156A013  1
1992 Taylor SI, Cama A, Accili D, Barbetti F, Quon MJ, De La Luz Sierra M, Suzuki Y, Koller E, Levy-Toledano R, Wertheimer E, Moncada VY, Kadowaki H, Kadowaki T. Mutations in the insulin receptor gene Endocrine Reviews. 13: 566-595. PMID 1330507 DOI: 10.1210/Edrv-13-3-566  1
1992 Taylor SI. Lilly lecture: Molecular mechanisms of insulin resistance: Lessons from patients with mutations in the insulin-receptor gene Diabetes. 41: 1473-1490. PMID 1327927 DOI: 10.2337/Diab.41.11.1473  1
1992 Cama A, Quon MJ, De La Luz Sierra M, Taylor SI. Substitution of isoleucine for methionine at position 1153 in the β-subunit of the human insulin receptor: A mutation that impairs receptor tyrosine kinase activity, receptor endocytosis, and insulin action Journal of Biological Chemistry. 267: 8383-8389. PMID 1314826  1
1992 Accili D, Cama A, Barbetti F, Kadowaki H, Kadowaki T, Taylor SI. Insulin resistance due to mutations of the insulin receptor gene: An overview Journal of Endocrinological Investigation: Official Journal of the Italian Scociety of Endocrinology. 15: 857-864. PMID 1291599 DOI: 10.1007/Bf03348820  1
1991 Taylor SI, Kadowaki T, Accili D, Cama A, Kadowaki H, McKeon C, Moncada V, Marcus-Samuels B, Bevins C, Ojamaa K, Frapier C, Beitz L, Perrotti N, Rees-Jones R, Margolis R, et al. Mutations in the insulin receptor gene in genetic forms of insulin resistance Recent Progress in Hormone Research. 46: 185-213. PMID 2177906 DOI: 10.1016/B978-0-12-571146-3.50011-0  1
1991 Accili D, Taylor SI. Targeted inactivation of the insulin receptor gene in mouse 3T3-L1 fibroblasts via homologous recombination Proceedings of the National Academy of Sciences of the United States of America. 88: 4708-4712. PMID 2052553  1
1991 Taylor SI, Accili D, Cama A, Imano E, Kadowaki H, Kadowaki T. Unusual forms of insulin resistance Annual Review of Medicine. 42: 373-379. PMID 2035982 DOI: 10.1146/Annurev.Me.42.020191.002105  1
1991 Raben N, Barbetti F, Cama A, Lesniak MA, Lillioja S, Zimmet P, Serjeantson SW, Taylor SI, Roth J. Normal coding sequence of insulin gene in Pima Indians and Nauruans, two groups with highest prevalence of type II diabetes Diabetes. 40: 118-122. PMID 2015966 DOI: 10.2337/Diab.40.1.118  1
1991 Taylor SI, Cama A, Accili D, Barbetti F, Imano E, Kadowaki H, Kadowaki T. Genetic basis of endocrine disease 1: Molecular genetics of insulin resistant diabetes mellitus Journal of Clinical Endocrinology and Metabolism. 73: 1158-1163. PMID 1955495 DOI: 10.1210/Jcem-73-6-1158  1
1991 Cama A, De la luz Sierra M, Ottini L, Kadowaki T, Gorden P, Imperato-McGinley J, Taylor SI. A mutation in the tyrosine kinase domain of the insulin receptor associated with insulin resistance in an obese woman Journal of Clinical Endocrinology and Metabolism. 73: 894-901. PMID 1890161 DOI: 10.1210/Jcem-73-4-894  1
1991 Accili D, Mosthaf L, Ullrich A, Taylor SI. A mutation in the extracellular domain of the insulin receptor impairs the ability of insulin to stimulate receptor autophosphorylation Journal of Biological Chemistry. 266: 434-439. PMID 1845971  1
1991 Taylor SI, Accili D, Cama A, Kadowaki H, Kadowaki T, Imano E, Sierra ML. Mutations in the insulin receptor gene in patients with genetic syndromes of insulin resistance. Advances in Experimental Medicine and Biology. 293: 197-213. PMID 1767731 DOI: 10.1007/978-1-4684-5949-4_19  1
1991 Hurley DM, Accili D, Stratakis CA, Karl M, Vamvakopoulos N, Rorer E, Constantine K, Taylor SI, Chrousos GP. Point mutation causing a single amino acid substitution in the hormone binding domain of the glucocorticoid receptor in familial glucocorticoid resistance Journal of Clinical Investigation. 87: 680-686. PMID 1704018 DOI: 10.1172/Jci115046  1
1991 Imano E, Kadowaki H, Kadowaki T, Iwama N, Watarai T, Kawamori R, Kamada T, Taylor SI. Two patients with insulin resistance due to decreased levels of insulin-receptor mRNA Diabetes. 40: 548-557. PMID 1673662 DOI: 10.2337/Diab.40.5.548  1
1991 Kadowaki T, Kadowaki H, Accili D, Yazaki Y, Taylor SI. Substitution of arginine for histidine at position 209 in the α-subunit of the human insulin receptor: A mutation that impairs receptor dimerization and transport of receptors to the cell surface Journal of Biological Chemistry. 266: 21224-21231. PMID 1657953  1
1990 Kadowaki T, Kadowaki H, Rechler MM, Serrano-Rios M, Roth J, Gorden P, Taylor SI. Five mutant alleles of the insulin receptor gene in patients with genetic forms of insulin resistance Journal of Clinical Investigation. 86: 254-264. PMID 2365819 DOI: 10.1172/Jci114693  1
1990 Cama A, Patterson AP, Kadowaki T, Kadowaki H, Siegel G, D'Ambrosio D, Lillioja S, Roth J, Taylor SI. The amino acid sequence of the insulin receptor is normal in an insulin-resistant Pima Indian Journal of Clinical Endocrinology and Metabolism. 70: 1155-1161. PMID 2318937 DOI: 10.1210/Jcem-70-4-1155  1
1990 Kadowaki T, Kadowaki H, Taylor SI. A nonsense mutation causing decreased levels of insulin receptor mRNA: Detection by a simplified technique for direct sequencing of genomic DNA amplified by the polymerase chain reaction Proceedings of the National Academy of Sciences of the United States of America. 87: 658-662. PMID 2300553 DOI: 10.1073/Pnas.87.2.658  1
1990 McKeon C, Moncada V, Pham T, Salvatore P, Kadowaki T, Accili D, Taylor SI. Structural and functional analysis of the insulin receptor promoter Molecular Endocrinology. 4: 647-656. PMID 2280779 DOI: 10.1210/Mend-4-4-647  1
1990 Barbetti F, Raben N, Kadowaki T, Cama A, Accili D, Gabbay KH, Merenich JA, Taylor SI, Roth J. Two unrelated patients with familial hyperproinsulinemia due to a mutation substituting histidine for arginine at position 65 in the proinsulin molecule: Identification of the mutation by direct sequencing of genomic deoxyribonucleic acid amplified by polymerase chain reaction Journal of Clinical Endocrinology and Metabolism. 71: 164-169. PMID 2196279 DOI: 10.1210/Jcem-71-1-164  1
1990 Gorden DL, Robert A, Moncada VY, Taylor SI, Mühlhauser J, Carpentier JL. Cell surface alteration in Epstein-Barr virus-transformed cells from patients with extreme insulin resistance Diabetes. 39: 924-927. PMID 2165004 DOI: 10.2337/diab.39.8.924  1
1990 Margolis RN, Tanner K, Seminara D, Taylor SI. Insulin receptors in developing rat liver. Receptor autophosphorylation and phosphorylation of the endogenous substrate pp120/HA4 (ecto-ATPase) in fetal and neonatal liver Biology of the Neonate. 58: 227-235. PMID 2148694 DOI: 10.1159/000243272  1
1990 Margolis RN, Schell MJ, Taylor SI, Hubbard AL. Hepatocyte plasma membrane ECTO-ATPase (pp120/HA4) is a substrate for tyrosine kinase activity of the insulin receptor. Biochemical and Biophysical Research Communications. 166: 562-6. PMID 2137339 DOI: 10.1016/0006-291X(90)90845-E  1
1990 Taylor SI, Kadowaki T, Kadowaki H, Accili D, Cama A, McKeon C. Mutations in insulin-receptor gene in insulin-resistant patients Diabetes Care. 13: 257-279. PMID 1968373 DOI: 10.2337/Diacare.13.3.257  1
1990 Taylor SI, Cama A, Kadowaki H, Kadowaki T, Accili D. Mutations of the human insulin receptor gene Trends in Endocrinology and Metabolism. 1: 134-139. DOI: 10.1016/1043-2760(90)90024-W  1
1989 Kadowaki H, Kadowaki T, Wondisford FE, Taylor SI. Use of polymerase chain reaction catalyzed by Taq DNA polymerase for site-specific mutagenesis Gene. 76: 161-166. PMID 2744478 DOI: 10.1016/0378-1119(89)90018-8  1
1989 Bloise W, Wajchenberg BL, Moncada VY, Marcus-Samuels B, Taylor SI. Atypical antiinsulin receptor antibodies in a patient with type B insulin resistance and scleroderma Journal of Clinical Endocrinology and Metabolism. 68: 227-231. PMID 2642487 DOI: 10.1210/Jcem-68-1-227  1
1989 Accili D, Elbein S, Mckeon C, Taylor SI. A new EcoRI polymorphism for the insulin receptor gene Nucleic Acids Research. 17: 821. PMID 2563580 DOI: 10.1093/nar/17.2.821  1
1989 Fanciulli M, Paggi MG, Mancini A, Del Carlo C, Floridi A, Taylor SI, Perrotti N. pp-120: A common endogenous substrate for insulin and IGF-1 receptor-associated tyrosine kinase activity in the highly malignant AS-30D rat hepatoma cells Biochemical and Biophysical Research Communications. 160: 168-173. PMID 2469417 DOI: 10.1016/0006-291X(89)91636-7  1
1988 Grunberger G, Weiner JL, Silverman R, Taylor S, Gorden P. Factitious hypoglycemia due to surreptitious administration of insulin. Diagnosis, treatment, and long-term follow-up. Annals of Internal Medicine. 108: 252-7. PMID 3277509 DOI: 10.7326/0003-4819-108-2-252  1
1988 Moller DE, Ratner RE, Borenstein DG, Taylor SI. Autoantibodies to the insulin receptor as a cause of autoimmune hypoglycemia in systemic lupus erythematosus The American Journal of Medicine. 84: 334-338. PMID 3044073 DOI: 10.1016/0002-9343(88)90436-6  1
1988 Margolis RN, Taylor SI, Seminara D, Hubbard AL. Identification of pp120, an endogenous substrate for the hepatocyte insulin receptor tyrosine kinase, as an integral membrane glycoprotein of the bile canalicular domain. Proceedings of the National Academy of Sciences of the United States of America. 85: 7256-9. PMID 2845403 DOI: 10.1073/Pnas.85.19.7256  1
1988 Perrotti N, Accili D, Phillips SA, Taylor SI. Protein phosphorylation and insulin action Advances in Experimental Medicine and Biology. 231: 495-502. PMID 2843011 DOI: 10.1007/978-1-4684-9042-8_42  1
1988 Ojamaa K, Hedo JA, Roberts CT, Moncada VY, Gorden P, Ullrich A, Taylor SI. Defects in human insulin receptor gene expression Molecular Endocrinology. 2: 242-247. PMID 2840573 DOI: 10.1210/Mend-2-3-242  1
1988 Kadowaki T, Bevins CL, Cama A, Ojamaa K, Marcus-Samuels B, Kadowaki H, Beitz L, Mckeon C, Taylor SI. Two mutant alleles of the insulin receptor gene in a patient with extreme insulin resistance Science. 240: 787-790. PMID 2834824 DOI: 10.1126/Science.2834824  1
1988 Cama A, Marcus-Samuels B, Taylor SI. Immunological abnormalities in insulin receptors on cultured EBV-transformed lymphocytes from insulin-resistant patient with leprechaunism Diabetes. 37: 982-988. PMID 2454859 DOI: 10.2337/Diab.37.7.982  1
1987 Selinger S, Tsai J, Pulini M, Saperstein A, Taylor S. Autoimmune thrombocytopenia and primary biliary cirrhosis with hypoglycemia and insulin receptor autoantibodies. A case report Annals of Internal Medicine. 107: 686-688. PMID 3310794 DOI: 10.7326/0003-4819-107-5-686  1
1986 Taylor SI, Marcus-Samuels B, Ryan-Young J, Leventhal S, Elders MJ. Genetics of the insulin receptor defect in a patient with extreme insulin resistance. The Journal of Clinical Endocrinology and Metabolism. 62: 1130-5. PMID 3009519 DOI: 10.1210/jcem-62-6-1130  1
1985 Whittaker J, Zick Y, Roth J, Taylor SI. Insulin-stimulated receptor phosphorylation appears normal in cultured Epstein-Barr virus-transformed lymphocyte cell lines derived from patients with extreme insulin resistance Journal of Clinical Endocrinology and Metabolism. 60: 381-386. PMID 2981245 DOI: 10.1210/Jcem-60-2-381  1
1984 Wagman LD, Lambert SR, McElduff A, Roth J, Gorden P, Taylor SI. Downregulation occurs normally in cultured Epstein-Barr virus-transformed lymphocytes from patients with extreme insulin resistance. Discrepancy between downregulation in vivo and in vitro Diabetes. 33: 421-427. PMID 6327434 DOI: 10.2337/Diab.33.5.421  1
1984 Grunberger G, Zick Y, Taylor SI, Gorden P. Tumor-promoting phorbol ester stimulates tyrosine phosphorylation in U-937 monocytes Proceedings of the National Academy of Sciences of the United States of America. 81: 2762-2766. PMID 6201862 DOI: 10.1073/Pnas.81.9.2762  1
1983 Zick Y, Rees-Jones RW, Grunberger G, Taylor SI, Moncada V, Gorden P, Roth J. The insulin-stimulated receptor kinase is a tyrosine-specific casein kinase European Journal of Biochemistry. 137: 631-637. PMID 6363065 DOI: 10.1111/J.1432-1033.1983.Tb07872.X  1
1983 Taylor SI, Leventhal S. Defect in cooperativity in insulin receptors from a patient with a congenital form of extreme insulin resistance. The Journal of Clinical Investigation. 71: 1676-85. PMID 6345588 DOI: 10.1172/JCI110922  1
1983 Zick Y, Grunberger G, Podskalny JM, Moncada V, Taylor SI, Gorden P, Roth J. Insulin stimulates phosphorylation of serine residues in soluble insulin receptors Biochemical and Biophysical Research Communications. 116: 1129-1135. PMID 6316966 DOI: 10.1016/S0006-291X(83)80260-5  1
1981 Taylor SI, Roth J, Blizzard RM, Elders MJ. Qualitative abnormalities in insulin binding in a patient with extreme insulin resistance: decreased sensitivity to alterations in temperature and pH Proceedings of the National Academy of Sciences of the United States of America. 78: 7157-7161. PMID 7031672 DOI: 10.1073/Pnas.78.11.7157  1
1975 Taylor SI, Mukherjee C, Jungas RL. Regulation of pyruvate dehydrogenase in isolated rat liver mitochondria. Effects of octanoate, oxidation-reduction state, and adenosine triphosphate to adenosine diphosphate ratio. The Journal of Biological Chemistry. 250: 2028-35. PMID 1116996  1
1974 Taylor SI, Jungas RL. Regulation of lipogenesis in adipose tissue: the significance of the activation of pyruvate dehydrogenase by insulin. Archives of Biochemistry and Biophysics. 164: 12-9. PMID 4279624 DOI: 10.1016/0003-9861(74)90002-2  1
1973 Taylor SI, Mukherjee C, Jungas RL. Studies on the mechanism of activation of adipose tissue pyruvate dehydrogenase by insulin. The Journal of Biological Chemistry. 248: 73-81. PMID 4735008  1
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