Roland Stein - Publications

Affiliations: 
Vanderbilt University, Nashville, TN 
Area:
Molecular Biology, Animal Physiology Biology, Genetics

65 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

PUBLICATION UPDATES TEMPORARILY DISABLED DURING DATABASE UPDATE, SORRY!

Year Citation  Score
2020 Tellez K, Hang Y, Gu X, Chang CA, Stein RW, Kim SK. In vivo studies of glucagon secretion by human islets transplanted in mice. Nature Metabolism. 2: 547-557. PMID 32694729 DOI: 10.1038/s42255-020-0213-x  1
2020 Hu R, Walker E, Huang C, Xu Y, Weng C, Erickson GE, Coldren A, Yang X, Brissova M, Kaverina I, Balamurugan AN, Wright CVE, Li Y, Stein R, Gu G. Myt Transcription Factors Prevent Stress-Response Gene Overactivation to Enable Postnatal Pancreatic β Cell Proliferation, Function, and Survival. Developmental Cell. 53: 754. PMID 32574594 DOI: 10.1016/j.devcel.2020.06.007  0.56
2020 Hu R, Walker E, Huang C, Xu Y, Weng C, Erickson GE, Coldren A, Yang X, Brissova M, Kaverina I, Appakalai BN, Wright CVE, Li Y, Stein R, Gu G. Myt Transcription Factors Prevent Stress-Response Gene Overactivation to Enable Postnatal Pancreatic β Cell Proliferation, Function, and Survival. Developmental Cell. PMID 32359405 DOI: 10.1016/j.devcel.2020.04.003  0.56
2019 Spaeth JM, Liu JH, Peters D, Guo M, Osipovich AB, Mohammadi F, Roy N, Bhushan A, Magnuson MA, Hebrok M, Wright CVE, Stein R. The Pdx1 Bound Swi/Snf Chromatin Remodeling Complex Regulates Pancreatic Progenitor Cell Proliferation and Mature Islet β Cell Function. Diabetes. PMID 31201281 DOI: 10.2337/db19-0349  0.56
2018 Cyphert HA, Walker EM, Hang Y, Dhawan S, Haliyur R, Bonatakis L, Avrahami D, Brissova M, Kaestner KH, Bhushan A, Powers AC, Stein R. "Examining How the MAFB Transcription Factor Affects Islet β Cell Function Postnatally". Diabetes. PMID 30425060 DOI: 10.2337/db18-0903  1
2018 Huang C, Walker EM, Dadi PK, Hu R, Xu Y, Zhang W, Sanavia T, Mun J, Liu J, Nair GG, Tan HYA, Wang S, Magnuson MA, Stoeckert CJ, Hebrok M, ... ... Stein R, et al. Synaptotagmin 4 Regulates Pancreatic β Cell Maturation by Modulating the Ca Sensitivity of Insulin Secretion Vesicles. Developmental Cell. PMID 29656931 DOI: 10.1016/j.devcel.2018.03.013  0.56
2018 Iacovazzo D, Flanagan SE, Walker E, Quezado R, de Sousa Barros FA, Caswell R, Johnson MB, Wakeling M, Brändle M, Guo M, Dang MN, Gabrovska P, Niederle B, Christ E, Jenni S, ... ... Stein R, et al. MAFA missense mutation causes familial insulinomatosis and diabetes mellitus. Proceedings of the National Academy of Sciences of the United States of America. PMID 29339498 DOI: 10.1073/pnas.1712262115  0.56
2017 Spaeth JM, Gupte M, Perelis M, Yang YP, Cyphert H, Guo S, Liu JH, Guo M, Bass J, Magnuson MA, Wright C, Stein R. Defining a Novel Role for the PDX1 Transcription Factor in Islet β Cell Maturation and Proliferation During Weaning. Diabetes. PMID 28705881 DOI: 10.2337/db16-1516  0.56
2016 Banerjee RR, Cyphert HA, Walker EM, Chakravarthy H, Peiris H, Gu X, Liu Y, Conrad E, Goodrich L, Stein RW, Kim SK. Gestational diabetes from inactivation of prolactin receptor and MafB in islet β-cells. Diabetes. PMID 27217483 DOI: 10.2337/db15-1527  0.56
2016 Dai C, Kayton NS, Shostak A, Poffenberger G, Cyphert HA, Aramandla R, Thompson C, Papagiannis IG, Emfinger C, Shiota M, Stafford JM, Greiner DL, Herrera PL, Shultz LD, Stein R, et al. Stress-impaired transcription factor expression and insulin secretion in transplanted human islets. The Journal of Clinical Investigation. PMID 27064285 DOI: 10.1172/JCI83657  0.56
2016 Ganic E, Singh T, Luan C, Fadista J, Johansson JK, Cyphert HA, Bennet H, Storm P, Prost G, Ahlenius H, Renström E, Stein R, Groop L, Fex M, Artner I. MafA-Controlled Nicotinic Receptor Expression Is Essential for Insulin Secretion and Is Impaired in Patients with Type 2 Diabetes. Cell Reports. 14: 1991-2002. PMID 26904947 DOI: 10.1016/j.celrep.2016.02.002  0.56
2015 Paul L, Walker EM, Drosos Y, Cyphert HA, Neale G, Stein R, South J, Grosveld G, Herrera PL, Sosa-Pineda B. Lack of Prox1 Downregulation Disrupts the Expansion and Maturation of Postnatal Murine β-cells. Diabetes. PMID 26631740 DOI: 10.2337/db15-0713  0.56
2015 Conrad E, Dai C, Spaeth J, Guo M, Cyphert HA, Scoville D, Carroll J, Yu WM, Goodrich LV, Harlan DM, Grove KL, Roberts CT, Powers AC, Gu G, Stein R. The MAFB transcription factor impacts islet α-cell function in rodents and represents a unique signature of primate islet β-cells. American Journal of Physiology. Endocrinology and Metabolism. ajpendo.00285.2015. PMID 26554594 DOI: 10.1152/ajpendo.00285.2015  0.56
2015 Zhu X, Hu R, Brissova M, Stein RW, Powers AC, Gu G, Kaverina I. Microtubules Negatively Regulate Insulin Secretion in Pancreatic β Cells. Developmental Cell. 34: 656-68. PMID 26418295 DOI: 10.1016/j.devcel.2015.08.020  0.56
2015 Scoville DW, Cyphert HA, Liao L, Xu J, Reynolds A, Guo S, Stein R. MLL3 and MLL4 Methyltransferases Bind to the MAFA and MAFB Transcription Factors to Regulate Islet β-Cell Function. Diabetes. 64: 3772-83. PMID 26180087 DOI: 10.2337/db15-0281  0.56
2015 Spaeth JM, Hunter CS, Bonatakis L, Guo M, French CA, Slack I, Hara M, Fisher SE, Ferrer J, Morrisey EE, Stanger BZ, Stein R. The FOXP1, FOXP2 and FOXP4 transcription factors are required for islet alpha cell proliferation and function in mice. Diabetologia. PMID 26021489 DOI: 10.1007/s00125-015-3635-3  0.56
2015 McKenna B, Guo M, Reynolds A, Hara M, Stein R. Dynamic recruitment of functionally distinct Swi/Snf chromatin remodeling complexes modulates Pdx1 activity in islet β cells. Cell Reports. 10: 2032-42. PMID 25801033 DOI: 10.1016/j.celrep.2015.02.054  0.56
2015 Maganti AV, Maier B, Tersey SA, Sampley ML, Mosley AL, Özcan S, Pachaiyappan B, Woster PM, Hunter CS, Stein R, Mirmira RG. Transcriptional activity of the islet β cell factor Pdx1 is augmented by lysine methylation catalyzed by the methyltransferase Set7/9. The Journal of Biological Chemistry. 290: 9812-22. PMID 25713082 DOI: 10.1074/jbc.M114.616219  0.56
2015 Matsuoka TA, Kaneto H, Kawashima S, Miyatsuka T, Tochino Y, Yoshikawa A, Imagawa A, Miyazaki J, Gannon M, Stein R, Shimomura I. Preserving Mafa expression in diabetic islet β-cells improves glycemic control in vivo. The Journal of Biological Chemistry. 290: 7647-57. PMID 25645923 DOI: 10.1074/jbc.M114.595579  0.56
2014 Ediger BN, Du A, Liu J, Hunter CS, Walp ER, Schug J, Kaestner KH, Stein R, Stoffers DA, May CL. Islet-1 Is essential for pancreatic β-cell function. Diabetes. 63: 4206-17. PMID 25028525 DOI: 10.2337/db14-0096  0.56
2014 Stahnke MJ, Dickel C, Schröder S, Kaiser D, Blume R, Stein R, Pouponnot C, Oetjen E. Inhibition of human insulin gene transcription and MafA transcriptional activity by the dual leucine zipper kinase. Cellular Signalling. 26: 1792-9. PMID 24726898 DOI: 10.1016/j.cellsig.2014.04.006  0.56
2014 Hang Y, Yamamoto T, Benninger RK, Brissova M, Guo M, Bush W, Piston DW, Powers AC, Magnuson M, Thurmond DC, Stein R. The MafA transcription factor becomes essential to islet β-cells soon after birth. Diabetes. 63: 1994-2005. PMID 24520122 DOI: 10.2337/db13-1001  0.56
2014 Gao T, McKenna B, Li C, Reichert M, Nguyen J, Singh T, Yang C, Pannikar A, Doliba N, Zhang T, Stoffers DA, Edlund H, Matschinsky F, Stein R, Stanger BZ. Pdx1 maintains β cell identity and function by repressing an α cell program. Cell Metabolism. 19: 259-71. PMID 24506867 DOI: 10.1016/j.cmet.2013.12.002  0.56
2013 Guo S, Dai C, Guo M, Taylor B, Harmon JS, Sander M, Robertson RP, Powers AC, Stein R. Inactivation of specific β cell transcription factors in type 2 diabetes. The Journal of Clinical Investigation. 123: 3305-16. PMID 23863625 DOI: 10.1172/JCI65390  0.56
2012 Yan L, Guo S, Brault M, Harmon J, Robertson RP, Hamid R, Stein R, Yang E. The B55α-containing PP2A holoenzyme dephosphorylates FOXO1 in islet β-cells under oxidative stress. The Biochemical Journal. 444: 239-47. PMID 22417654 DOI: 10.1042/BJ20111606  0.56
2012 Dai C, Brissova M, Hang Y, Thompson C, Poffenberger G, Shostak A, Chen Z, Stein R, Powers AC. Islet-enriched gene expression and glucose-induced insulin secretion in human and mouse islets. Diabetologia. 55: 707-18. PMID 22167125 DOI: 10.1007/s00125-011-2369-0  1
2011 Hang Y, Stein R. MafA and MafB activity in pancreatic β cells. Trends in Endocrinology and Metabolism: Tem. 22: 364-73. PMID 21719305 DOI: 10.1016/j.tem.2011.05.003  1
2011 Chen C, Chai J, Singh L, Kuo CY, Jin L, Feng T, Marzano S, Galeni S, Zhang N, Iacovino M, Qin L, Hara M, Stein R, Bromberg JS, Kyba M, et al. Characterization of an in vitro differentiation assay for pancreatic-like cell development from murine embryonic stem cells: detailed gene expression analysis. Assay and Drug Development Technologies. 9: 403-19. PMID 21395400 DOI: 10.1089/adt.2010.0314  0.56
2011 Liu J, Hunter CS, Du A, Ediger B, Walp E, Murray J, Stein R, May CL. Islet-1 regulates Arx transcription during pancreatic islet alpha-cell development. The Journal of Biological Chemistry. 286: 15352-60. PMID 21388963 DOI: 10.1074/jbc.M111.231670  0.56
2011 Hunter CS, Maestro MA, Raum JC, Guo M, Thompson FH, Ferrer J, Stein R. Hnf1α (MODY3) regulates β-cell-enriched MafA transcription factor expression. Molecular Endocrinology (Baltimore, Md.). 25: 339-47. PMID 21193557 DOI: 10.1210/me.2010-0362  0.56
2011 Pound LD, Hang Y, Sarkar SA, Wang Y, Milam LA, Oeser JK, Printz RL, Lee CE, Stein R, Hutton JC, O'Brien RM. The pancreatic islet β-cell-enriched transcription factor Pdx-1 regulates Slc30a8 gene transcription through an intronic enhancer. The Biochemical Journal. 433: 95-105. PMID 20942803 DOI: 10.1042/BJ20101488  1
2010 Artner I, Hang Y, Mazur M, Yamamoto T, Guo M, Lindner J, Magnuson MA, Stein R. MafA and MafB regulate genes critical to beta-cells in a unique temporal manner. Diabetes. 59: 2530-9. PMID 20627934 DOI: 10.2337/db10-0190  1
2010 Raum JC, Hunter CS, Artner I, Henderson E, Guo M, Elghazi L, Sosa-Pineda B, Ogihara T, Mirmira RG, Sussel L, Stein R. Islet β-cell-specific MafA transcription requires the 5′-Flanking conserved region 3 control domain Molecular and Cellular Biology. 30: 4234-4244. PMID 20584984 DOI: 10.1128/MCB.01396-09  0.56
2010 Guo S, Vanderford NL, Stein R. Phosphorylation within the MafA N terminus regulates C-terminal dimerization and DNA binding. The Journal of Biological Chemistry. 285: 12655-61. PMID 20208071 DOI: 10.1074/jbc.M110.105759  0.56
2009 Ogihara T, Vanderford NL, Maier B, Stein RW, Mirmira RG. Expression and function of Set7/9 in pancreatic islets. Islets. 1: 269-72. PMID 21099283 DOI: 10.4161/isl.1.3.9779  0.56
2009 Fernandez-Zapico ME, van Velkinburgh JC, Gutiérrez-Aguilar R, Neve B, Froguel P, Urrutia R, Stein R. MODY7 gene, KLF11, is a novel p300-dependent regulator of Pdx-1 (MODY4) transcription in pancreatic islet beta cells. The Journal of Biological Chemistry. 284: 36482-90. PMID 19843526 DOI: 10.1074/jbc.M109.028852  0.56
2009 Pechhold S, Stouffer M, Walker G, Martel R, Seligmann B, Hang Y, Stein R, Harlan DM, Pechhold K. Transcriptional analysis of intracytoplasmically stained, FACS-purified cells by high-throughput, quantitative nuclease protection. Nature Biotechnology. 27: 1038-42. PMID 19838197 DOI: 10.1038/nbt.1579  1
2009 Du A, Hunter CS, Murray J, Noble D, Cai CL, Evans SM, Stein R, May CL. Islet-1 is required for the maturation, proliferation, and survival of the endocrine pancreas. Diabetes. 58: 2059-69. PMID 19502415 DOI: 10.2337/db08-0987  0.56
2009 Guo S, Burnette R, Zhao L, Vanderford NL, Poitout V, Hagman DK, Henderson E, Ozcan S, Wadzinski BE, Stein R. The stability and transactivation potential of the mammalian MafA transcription factor are regulated by serine 65 phosphorylation. The Journal of Biological Chemistry. 284: 759-65. PMID 19004825 DOI: 10.1074/jbc.M806314200  0.56
2008 Vanhoose AM, Samaras S, Artner I, Henderson E, Hang Y, Stein R. MafA and MafB regulate Pdx1 transcription through the Area II control region in pancreatic beta cells. The Journal of Biological Chemistry. 283: 22612-9. PMID 18522939 DOI: 10.1074/jbc.M802902200  0.56
2008 Artner I, Hang Y, Guo M, Gu G, Stein R. MafA is a dedicated activator of the insulin gene in vivo. The Journal of Endocrinology. 198: 271-9. PMID 18515495 DOI: 10.1677/JOE-08-0063  1
2007 Matsuoka TA, Kaneto H, Stein R, Miyatsuka T, Kawamori D, Henderson E, Kojima I, Matsuhisa M, Hori M, Yamasaki Y. MafA regulates expression of genes important to islet beta-cell function. Molecular Endocrinology (Baltimore, Md.). 21: 2764-74. PMID 17636040 DOI: 10.1210/me.2007-0028  0.56
2007 Wiebe PO, Kormish JD, Roper VT, Fujitani Y, Alston NI, Zaret KS, Wright CV, Stein RW, Gannon M. Ptf1a binds to and activates area III, a highly conserved region of the Pdx1 promoter that mediates early pancreas-wide Pdx1 expression. Molecular and Cellular Biology. 27: 4093-104. PMID 17403901 DOI: 10.1128/MCB.01978-06  0.56
2007 Artner I, Blanchi B, Raum JC, Guo M, Kaneko T, Cordes S, Sieweke M, Stein R. MafB is required for islet beta cell maturation. Proceedings of the National Academy of Sciences of the United States of America. 104: 3853-8. PMID 17360442 DOI: 10.1073/pnas.0700013104  0.56
2006 Tweedie E, Artner I, Crawford L, Poffenberger G, Thorens B, Stein R, Powers AC, Gannon M. Maintenance of hepatic nuclear factor 6 in postnatal islets impairs terminal differentiation and function of beta-cells. Diabetes. 55: 3264-70. PMID 17130469 DOI: 10.2337/db06-0090  0.56
2006 Boyer DF, Fujitani Y, Gannon M, Powers AC, Stein RW, Wright CV. Complementation rescue of Pdx1 null phenotype demonstrates distinct roles of proximal and distal cis-regulatory sequences in pancreatic and duodenal expression. Developmental Biology. 298: 616-31. PMID 16962573 DOI: 10.1016/j.ydbio.2006.07.020  0.56
2006 Raum JC, Gerrish K, Artner I, Henderson E, Guo M, Sussel L, Schisler JC, Newgard CB, Stein R. FoxA2, Nkx2.2, and PDX-1 regulate islet beta-cell-specific mafA expression through conserved sequences located between base pairs -8118 and -7750 upstream from the transcription start site. Molecular and Cellular Biology. 26: 5735-43. PMID 16847327 DOI: 10.1128/MCB.00249-06  0.56
2006 Ueki K, Okada T, Hu J, Liew CW, Assmann A, Dahlgren GM, Peters JL, Shackman JG, Zhang M, Artner I, Satin LS, Stein R, Holzenberger M, Kennedy RT, Kahn CR, et al. Total insulin and IGF-I resistance in pancreatic beta cells causes overt diabetes. Nature Genetics. 38: 583-8. PMID 16642022 DOI: 10.1038/ng1787  0.56
2006 Poitout V, Hagman D, Stein R, Artner I, Robertson RP, Harmon JS. Regulation of the insulin gene by glucose and fatty acids. The Journal of Nutrition. 136: 873-6. PMID 16549443  0.56
2006 Artner I, Le Lay J, Hang Y, Elghazi L, Schisler JC, Henderson E, Sosa-Pineda B, Stein R. MafB: an activator of the glucagon gene expressed in developing islet alpha- and beta-cells. Diabetes. 55: 297-304. PMID 16443760 DOI: 10.2337/DIABETES.55.02.06.DB05-0946  1
2006 Fujitani Y, Fujitani S, Boyer DF, Gannon M, Kawaguchi Y, Ray M, Shiota M, Stein RW, Magnuson MA, Wright CV. Targeted deletion of a cis-regulatory region reveals differential gene dosage requirements for Pdx1 in foregut organ differentiation and pancreas formation. Genes & Development. 20: 253-66. PMID 16418487 DOI: 10.1101/gad.1360106  0.56
2005 Van Velkinburgh JC, Samaras SE, Gerrish K, Artner I, Stein R. Interactions between areas I and II direct pdx-1 expression specifically to islet cell types of the mature and developing pancreas. The Journal of Biological Chemistry. 280: 38438-44. PMID 16147997 DOI: 10.1074/jbc.M508594200  0.56
2005 Zhao L, Guo M, Matsuoka TA, Hagman DK, Parazzoli SD, Poitout V, Stein R. The islet beta cell-enriched MafA activator is a key regulator of insulin gene transcription. The Journal of Biological Chemistry. 280: 11887-94. PMID 15665000 DOI: 10.1074/jbc.M409475200  0.56
2004 Le Lay J, Matsuoka TA, Henderson E, Stein R. Identification of a novel PDX-1 binding site in the human insulin gene enhancer. The Journal of Biological Chemistry. 279: 22228-35. PMID 15028719 DOI: 10.1074/jbc.M312673200  0.56
2004 Matsuoka TA, Artner I, Henderson E, Means A, Sander M, Stein R. The MafA transcription factor appears to be responsible for tissue-specific expression of insulin. Proceedings of the National Academy of Sciences of the United States of America. 101: 2930-3. PMID 14973194 DOI: 10.1073/pnas.0306233101  0.56
2004 Gerrish K, Van Velkinburgh JC, Stein R. Conserved transcriptional regulatory domains of the pdx-1 gene. Molecular Endocrinology (Baltimore, Md.). 18: 533-48. PMID 14701942 DOI: 10.1210/me.2003-0371  0.4
2004 Qiu Y, Guo M, Huang S, Stein R. Acetylation of the BETA2 transcription factor by p300-associated factor is important in insulin gene expression. The Journal of Biological Chemistry. 279: 9796-802. PMID 14701848 DOI: 10.1074/jbc.M307577200  0.56
2003 Griffin D, Penberthy WT, Lum H, Stein RW, Taylor WL. Isolation of the B3 transcription factor of the Xenopus TFIIIA gene. Gene. 313: 179-88. PMID 12957389 DOI: 10.1016/S0378-1119(03)00678-4  0.56
2003 Matsuoka TA, Zhao L, Artner I, Jarrett HW, Friedman D, Means A, Stein R. Members of the large Maf transcription family regulate insulin gene transcription in islet beta cells. Molecular and Cellular Biology. 23: 6049-62. PMID 12917329 DOI: 10.1128/MCB.23.17.6049-6062.2003  0.56
2003 Samaras SE, Zhao L, Means A, Henderson E, Matsuoka TA, Stein R. The islet beta cell-enriched RIPE3b1/Maf transcription factor regulates pdx-1 expression. The Journal of Biological Chemistry. 278: 12263-70. PMID 12551916 DOI: 10.1074/jbc.M210801200  0.56
2003 Martin CC, Svitek CA, Oeser JK, Henderson E, Stein R, O'Brien RM. Upstream stimulatory factor (USF) and neurogenic differentiation/beta-cell E box transactivator 2 (NeuroD/BETA2) contribute to islet-specific glucose-6-phosphatase catalytic-subunit-related protein (IGRP) gene expression. The Biochemical Journal. 371: 675-86. PMID 12540293 DOI: 10.1042/BJ20021585  0.56
2003 Cissell MA, Zhao L, Sussel L, Henderson E, Stein R. Transcription factor occupancy of the insulin gene in vivo. Evidence for direct regulation by Nkx2.2. The Journal of Biological Chemistry. 278: 751-6. PMID 12426319 DOI: 10.1074/jbc.M205905200  0.56
2002 Petersen HV, Jensen JN, Stein R, Serup P. Glucose induced MAPK signalling influences NeuroD1-mediated activation and nuclear localization. Febs Letters. 528: 241-5. PMID 12297313 DOI: 10.1016/S0014-5793(02)03318-5  0.56
2002 Samaras SE, Cissell MA, Gerrish K, Wright CV, Gannon M, Stein R. Conserved sequences in a tissue-specific regulatory region of the pdx-1 gene mediate transcription in Pancreatic beta cells: role for hepatocyte nuclear factor 3 beta and Pax6. Molecular and Cellular Biology. 22: 4702-13. PMID 12052878  0.4
2002 Qiu Y, Guo M, Huang S, Stein R. Insulin gene transcription is mediated by interactions between the p300 coactivator and PDX-1, BETA2, and E47. Molecular and Cellular Biology. 22: 412-20. PMID 11756538  0.56
Show low-probability matches.