Kenneth R. Chien - Publications

Affiliations: 
University of California, San Diego, La Jolla, CA 
Area:
Molecular Biology

217 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Grote Beverborg N, Später D, Knöll R, Hidalgo A, Yeh ST, Elbeck Z, Silljé HHW, Eijgenraam TR, Siga H, Zurek M, Palmér M, Pehrsson S, Albery T, Bomer N, Hoes MF, ... ... Chien KR, et al. Phospholamban antisense oligonucleotides improve cardiac function in murine cardiomyopathy. Nature Communications. 12: 5180. PMID 34462437 DOI: 10.1038/s41467-021-25439-0  1
2021 Yang R, Goedel A, Kang Y, Si C, Chu C, Zheng Y, Chen Z, Gruber PJ, Xiao Y, Zhou C, Witman N, Eroglu E, Leung CY, Chen Y, Fu J, ... ... Chien KR, et al. Amnion signals are essential for mesoderm formation in primates. Nature Communications. 12: 5126. PMID 34446705 DOI: 10.1038/s41467-021-25186-2  1
2021 Eroglu E, Schell JP, Chien KR. PHF7 directs cardiac reprogramming. Nature Cell Biology. 23: 440-442. PMID 33941893 DOI: 10.1038/s41556-021-00684-z  1
2021 Santoro F, Chien KR, Sahara M. Isolation of human ESC-derived cardiac derivatives and embryonic heart cells for population and single-cell RNA-seq analysis. Star Protocols. 2: 100339. PMID 33644774 DOI: 10.1016/j.xpro.2021.100339  1
2020 Foo KS, Lehtinen ML, Leung CY, Lian X, Xu J, Keung W, Geng L, Kolstad TRS, Thams S, Wong AO, Wong N, Bylund K, Zhou C, He X, Jin SB, ... ... Chien KR, et al. Human ISL1 Ventricular Progenitors Self-Assemble into an In Vivo Functional Heart Patch and Preserve Cardiac Function Post Infarction. Molecular Therapy : the Journal of the American Society of Gene Therapy. PMID 33296664 DOI: 10.1016/j.ymthe.2020.11.015  1
2020 Witman N, Zhou C, Beverborg NG, Sahara M, Chien KR. Corrigendum to "Cardiac progenitors and paracrine mediators in cardiogenesis and heart regeneration" [Semin. Cell Dev. Biol. Vol.100 (2020) 29-51]. Seminars in Cell & Developmental Biology. PMID 33039299 DOI: 10.1016/j.semcdb.2020.09.008  1
2020 Mononen MM, Leung CY, Chien KR. Trajectory mapping of human embryonic stem cell cardiogenesis reveals lineage branch points and an ISL1 progenitor-derived cardiac fibroblast lineage. Stem Cells (Dayton, Ohio). PMID 32497389 DOI: 10.1002/Stem.3236  1
2020 Almquist J, Rikard M, Wågberg M, Bruce AC, Gennemark P, Fritsche-Danielson R, Chien KR, Peirce SM, Hansson K, Lundahl A. Model-based analysis reveals a sustained and dose-dependent acceleration of wound healing by VEGF-A mRNA (AZD8601). Cpt: Pharmacometrics & Systems Pharmacology. PMID 32438492 DOI: 10.1002/psp4.12516  1
2020 Xu J, Zhou C, Foo KS, Yang R, Xiao Y, Bylund K, Sahara M, Chien KR. Genome-Wide CRISPR Screen Identifies ZIC2 As An Essential Gene That Controls The Cell-Fate of Early Mesodermal Precursors To Human Heart Progenitors. Stem Cells (Dayton, Ohio). PMID 32129551 DOI: 10.1002/Stem.3168  1
2019 Witman N, Zhou C, Grote Beverborg N, Sahara M, Chien KR. Cardiac progenitors and paracrine mediators in cardiogenesis and heart regeneration. Seminars in Cell & Developmental Biology. PMID 31862220 DOI: 10.1016/J.Semcdb.2019.10.011  1
2019 Goedel A, Grote Beverborg N, Sahara M, Chien KR. In search of the next super models. Embo Molecular Medicine. e11502. PMID 31736275 DOI: 10.15252/Emmm.201911502  1
2019 Yu Z, Witman N, Wang W, Li D, Yan B, Deng M, Wang X, Wang H, Zhou G, Liu W, Sahara M, Cao Y, Fritsche-Danielson R, Zhang W, Fu W, ... Chien KR, et al. Cell-mediated delivery of VEGF modified mRNA enhances blood vessel regeneration and ameliorates murine critical limb ischemia. Journal of Controlled Release : Official Journal of the Controlled Release Society. PMID 31425721 DOI: 10.1016/J.Jconrel.2019.08.014  1
2019 Gan LM, Lagerström-Fermér M, Carlsson LG, Arfvidsson C, Egnell AC, Rudvik A, Kjaer M, Collén A, Thompson JD, Joyal J, Chialda L, Koernicke T, Fuhr R, Chien KR, Fritsche-Danielson R. Intradermal delivery of modified mRNA encoding VEGF-A in patients with type 2 diabetes. Nature Communications. 10: 871. PMID 30787295 DOI: 10.1038/S41467-019-08852-4  1
2019 Chien KR, Frisén J, Fritsche-Danielson R, Melton DA, Murry CE, Weissman IL. Regenerating the field of cardiovascular cell therapy. Nature Biotechnology. PMID 30778231 DOI: 10.1038/S41587-019-0042-1  1
2019 Sahara M, Santoro F, Sohlmér J, Zhou C, Witman N, Leung CY, Mononen M, Bylund K, Gruber P, Chien KR. Population and Single-Cell Analysis of Human Cardiogenesis Reveals Unique LGR5 Ventricular Progenitors in Embryonic Outflow Tract. Developmental Cell. PMID 30713072 DOI: 10.1016/J.Devcel.2019.01.005  1
2018 Sun N, Ning B, Hansson KM, Bruce AC, Seaman SA, Zhang C, Rikard M, DeRosa CA, Fraser CL, Wågberg M, Fritsche-Danielson R, Wikström J, Chien KR, Lundahl A, Hölttä M, et al. Modified VEGF-A mRNA induces sustained multifaceted microvascular response and accelerates diabetic wound healing. Scientific Reports. 8: 17509. PMID 30504800 DOI: 10.1038/S41598-018-35570-6  1
2018 Xu J, Gruber PJ, Chien KR. SMAD4 is essential for human cardiac mesodermal precursor cell formation. Stem Cells (Dayton, Ohio). PMID 30376214 DOI: 10.1002/Stem.2943  1
2018 Grankvist R, Jensen-Urstad M, Clarke J, Lehtinen M, Little P, Lundberg J, Arnberg F, Jonsson S, Chien KR, Holmin S. Superselective Endovascular Tissue Access Using Trans-Vessel Wall Technique - Feasibility Study for Treatment Applications in Heart, Pancreas, and Kidney in Swine. Journal of Internal Medicine. PMID 30289186 DOI: 10.1111/Joim.12841  0.01
2018 Carlsson L, Clarke JC, Yen C, Gregoire F, Albery T, Billger M, Egnell AC, Gan LM, Jennbacken K, Johansson E, Linhardt G, Martinsson S, Sadiq MW, Witman N, Wang QD, ... ... Chien KR, et al. Biocompatible, Purified mRNA Improves Cardiac Function after Intracardiac Injection 1 Week Post-myocardial Infarction in Swine. Molecular Therapy. Methods & Clinical Development. 9: 330-346. PMID 30038937 DOI: 10.1016/J.Omtm.2018.04.003  1
2018 Sahara M, Eroglu E, Chien KR. Lnc'ed in to Cardiogenesis. Cell Stem Cell. 22: 787-789. PMID 29859167 DOI: 10.1016/J.Stem.2018.05.012  1
2018 Foo KS, Lehtinen ML, Leung CY, Lian X, Xu J, Keung W, Geng L, Kolstad TRS, Thams S, Wong AO, Wong N, Bylund K, Zhou C, He X, Jin SB, ... ... Chien KR, et al. Human ISL1Ventricular Progenitors Self-Assemble into an In Vivo Functional Heart Patch and Preserve Cardiac Function Post Infarction. Molecular Therapy : the Journal of the American Society of Gene Therapy. PMID 29606507 DOI: 10.1016/J.Ymthe.2018.02.012  1
2017 Eroglu E, Chien KR. Heart Regeneration 4.0: Matrix Medicine. Developmental Cell. 42: 7-8. PMID 28697334 DOI: 10.1016/J.Devcel.2017.06.017  1
2016 Zangi L, Oliveira MS, Ye LY, Ma Q, Sultana N, Hadas Y, Chepurko E, Später D, Zhou B, Chew WL, Ebina W, Abrial M, Wang QD, Pu WT, Chien KR. An IGF1R-Dependent Pathway Drives Epicardial Adipose Tissue Formation After Myocardial Injury. Circulation. PMID 27803039 DOI: 10.1161/Circulationaha.116.022064  1
2016 Soh BS, Ng SY, Wu H, Buac K, Park JH, Lian X, Xu J, Foo KS, Felldin U, He X, Nichane M, Yang H, Bu L, Li RA, Lim B, ... Chien KR, et al. Corrigendum: Endothelin-1 supports clonal derivation and expansion of cardiovascular progenitors derived from human embryonic stem cells. Nature Communications. 7: 12118. PMID 27431579 DOI: 10.1038/Ncomms12118  1
2016 Soh BS, Ng SY, Wu H, Buac K, Park JH, Lian X, Xu J, Foo KS, Felldin U, He X, Nichane M, Yang H, Bu L, Li RA, Lim B, ... Chien KR, et al. Endothelin-1 supports clonal derivation and expansion of cardiovascular progenitors derived from human embryonic stem cells. Nature Communications. 7: 10774. PMID 26952167 DOI: 10.1038/Ncomms10774  1
2015 Ljunggren HG, Chien KR. Next generation partnerships in translational science and medicine: Partnerships between academics, big pharma, biotech firms, philanthropists and patients look set to change the way science advances. Embo Reports. 16: 1246-9. PMID 26358954 DOI: 10.15252/Embr.201541065  0.01
2015 Sahara M, Santoro F, Chien KR. Programming and reprogramming a human heart cell. The Embo Journal. 34: 710-38. PMID 25712211 DOI: 10.15252/Embj.201490563  1
2015 Sahara M, Hansson EM, Wernet O, Lui KO, Später D, Chien KR. Manipulation of a VEGF-Notch signaling circuit drives formation of functional vascular endothelial progenitors from human pluripotent stem cells. Cell Research. 25: 148. PMID 25553820 DOI: 10.1038/Cr.2015.2  1
2015 Chien KR, Zangi L, Lui KO. Synthetic chemically modified mRNA (modRNA): toward a new technology platform for cardiovascular biology and medicine. Cold Spring Harbor Perspectives in Medicine. 5: a014035. PMID 25301935 DOI: 10.1101/Cshperspect.A014035  1
2014 Drawnel FM, Boccardo S, Prummer M, Delobel F, Graff A, Weber M, Gérard R, Badi L, Kam-Thong T, Bu L, Jiang X, Hoflack JC, Kiialainen A, Jeworutzki E, Aoyama N, ... ... Chien KR, et al. Disease modeling and phenotypic drug screening for diabetic cardiomyopathy using human induced pluripotent stem cells. Cell Reports. 9: 810-21. PMID 25437537 DOI: 10.1016/J.Celrep.2014.09.055  1
2014 Lui KO, Howie D, Ng SW, Liu S, Chien KR, Waldmann H. Tolerance induction to human stem cell transplants with extension to their differentiated progeny. Nature Communications. 5: 5629. PMID 25434740 DOI: 10.1038/Ncomms6629  1
2014 Später D, Hansson EM, Zangi L, Chien KR. How to make a cardiomyocyte. Development (Cambridge, England). 141: 4418-31. PMID 25406392 DOI: 10.1242/Dev.091538  1
2014 Soh BS, Buac K, Xu H, Li E, Ng SY, Wu H, Chmielowiec J, Jiang X, Bu L, Li RA, Cowan C, Chien KR. N-cadherin prevents the premature differentiation of anterior heart field progenitors in the pharyngeal mesodermal microenvironment. Cell Research. 24: 1420-32. PMID 25367124 DOI: 10.1038/Cr.2014.142  1
2014 Lian X, Xu J, Li J, Chien KR. Next-generation models of human cardiogenesis via genome editing. Cold Spring Harbor Perspectives in Medicine. 4: a013920. PMID 25237142 DOI: 10.1101/Cshperspect.A013920  1
2014 Lui KO, Zangi L, Chien KR. Cardiovascular regenerative therapeutics via synthetic paracrine factor modified mRNA. Stem Cell Research. 13: 693-704. PMID 25043723 DOI: 10.1016/J.Scr.2014.06.007  1
2014 Wang G, McCain ML, Yang L, He A, Pasqualini FS, Agarwal A, Yuan H, Jiang D, Zhang D, Zangi L, Geva J, Roberts AE, Ma Q, Ding J, Chen J, ... ... Chien KR, et al. Modeling the mitochondrial cardiomyopathy of Barth syndrome with induced pluripotent stem cell and heart-on-chip technologies. Nature Medicine. 20: 616-23. PMID 24813252 DOI: 10.1038/Nm.3545  1
2014 Sahara M, Hansson EM, Wernet O, Lui KO, Später D, Chien KR. Manipulation of a VEGF-Notch signaling circuit drives formation of functional vascular endothelial progenitors from human pluripotent stem cells. Cell Research. 24: 820-41. PMID 24810299 DOI: 10.1038/Cr.2014.59  1
2014 Bang ML, Gu Y, Dalton ND, Peterson KL, Chien KR, Chen J. The muscle ankyrin repeat proteins CARP, Ankrd2, and DARP are not essential for normal cardiac development and function at basal conditions and in response to pressure overload. Plos One. 9: e93638. PMID 24736439 DOI: 10.1371/Journal.Pone.0093638  0.36
2013 Feinberg AW, Ripplinger CM, van der Meer P, Sheehy SP, Domian I, Chien KR, Parker KK. Functional differences in engineered myocardium from embryonic stem cell-derived versus neonatal cardiomyocytes. Stem Cell Reports. 1: 387-96. PMID 24286027 DOI: 10.1016/J.Stemcr.2013.10.004  1
2013 Brade T, Pane LS, Moretti A, Chien KR, Laugwitz KL. Embryonic heart progenitors and cardiogenesis. Cold Spring Harbor Perspectives in Medicine. 3: a013847. PMID 24086063 DOI: 10.1101/Cshperspect.A013847  1
2013 Lui KO, Zangi L, Silva EA, Bu L, Sahara M, Li RA, Mooney DJ, Chien KR. Driving vascular endothelial cell fate of human multipotent Isl1+ heart progenitors with VEGF modified mRNA. Cell Research. 23: 1172-86. PMID 24018375 DOI: 10.1038/Cr.2013.112  1
2013 Zangi L, Lui KO, von Gise A, Ma Q, Ebina W, Ptaszek LM, Später D, Xu H, Tabebordbar M, Gorbatov R, Sena B, Nahrendorf M, Briscoe DM, Li RA, Wagers AJ, ... ... Chien KR, et al. Modified mRNA directs the fate of heart progenitor cells and induces vascular regeneration after myocardial infarction. Nature Biotechnology. 31: 898-907. PMID 24013197 DOI: 10.1038/Nbt.2682  1
2013 Yi BA, Mummery CL, Chien KR. Direct cardiomyocyte reprogramming: a new direction for cardiovascular regenerative medicine. Cold Spring Harbor Perspectives in Medicine. 3: a014050. PMID 24003244 DOI: 10.1101/cshperspect.a014050  1
2013 Später D, Abramczuk MK, Buac K, Zangi L, Stachel MW, Clarke J, Sahara M, Ludwig A, Chien KR. A HCN4+ cardiomyogenic progenitor derived from the first heart field and human pluripotent stem cells. Nature Cell Biology. 15: 1098-106. PMID 23974038 DOI: 10.1038/Ncb2824  1
2013 Lian X, Chien KR. The years of the monkey. Cell Research. 23: 1161-2. PMID 23958583 DOI: 10.1038/Cr.2013.111  1
2013 Chien K. Body, heal thyself. An interview with Kenneth Chien, Professor of Cardiovascular Research at the Department of Cell & Molecular Biology, and the Department of Medicine at Karolinska Institutet in Sweden. Interview by Holger Breithaupt. Embo Reports. 14: 755-758. PMID 23938329 DOI: 10.1038/Embor.2013.115  0.01
2013 Chien KR. Regenerative biology: heartbroken embryos heal. Nature. 498: 439-40. PMID 23783518 DOI: 10.1038/Nature12262  0.01
2013 Soh BS, Wu H, Chien KR. Cardiac regenerative medicine 2.0. Nature Biotechnology. 31: 209-11. PMID 23471068 DOI: 10.1038/Nbt.2524  1
2012 Hansson EM, Chien KR. Reprogramming a broken heart. Cell Stem Cell. 11: 3-4. PMID 22770235 DOI: 10.1016/J.Stem.2012.06.014  1
2012 Xu H, Yi BA, Chien KR. In vivo reprogramming for heart disease. Cell Research. 22: 1521-3. PMID 22751090 DOI: 10.1038/Cr.2012.101  1
2012 Chien KR, Yi BA, Xu H, Mummery CL. Cardiomyocyte reprogramming and the new age of cellular alchemy. Journal of Molecular and Cellular Cardiology. 53: 311-3. PMID 22749824 DOI: 10.1016/J.Yjmcc.2012.06.010  1
2012 Ptaszek LM, Mansour M, Ruskin JN, Chien KR. Towards regenerative therapy for cardiac disease. Lancet (London, England). 379: 933-42. PMID 22405796 DOI: 10.1016/S0140-6736(12)60075-0  1
2012 Xu H, Yi BA, Wu H, Bock C, Gu H, Lui KO, Park JH, Shao Y, Riley AK, Domian IJ, Hu E, Willette R, Lepore J, Meissner A, Wang Z, ... Chien KR, et al. Highly efficient derivation of ventricular cardiomyocytes from induced pluripotent stem cells with a distinct epigenetic signature. Cell Research. 22: 142-54. PMID 22064699 DOI: 10.1038/Cr.2011.171  1
2011 Chmielowiec J, Chang YS, Chien KR. A GPS for heart progenitor cell lineages. Molecular Therapy : the Journal of the American Society of Gene Therapy. 19: 1576-8. PMID 21886115 DOI: 10.1038/Mt.2011.158  0.01
2011 Knöll R, Linke WA, Zou P, Miocic S, Kostin S, Buyandelger B, Ku CH, Neef S, Bug M, Schäfer K, Knöll G, Felkin LE, Wessels J, Toischer K, Hagn F, ... ... Chien KR, et al. Telethonin deficiency is associated with maladaptation to biomechanical stress in the mammalian heart. Circulation Research. 109: 758-69. PMID 21799151 DOI: 10.1161/Circresaha.111.245787  1
2011 Vunjak-Novakovic G, Lui KO, Tandon N, Chien KR. Bioengineering heart muscle: a paradigm for regenerative medicine. Annual Review of Biomedical Engineering. 13: 245-67. PMID 21568715 DOI: 10.1146/Annurev-Bioeng-071910-124701  1
2011 Xu H, Yi BA, Chien KR. Shortcuts to making cardiomyocytes. Nature Cell Biology. 13: 191-3. PMID 21364566 DOI: 10.1038/Ncb0311-191  1
2011 Terada R, Warren S, Lu JT, Chien KR, Wessels A, Kasahara H. Ablation of Nkx2-5 at mid-embryonic stage results in premature lethality and cardiac malformation. Cardiovascular Research. 91: 289-99. PMID 21285290 DOI: 10.1093/Cvr/Cvr037  1
2011 Nakano H, Williams E, Hoshijima M, Sasaki M, Minamisawa S, Chien KR, Nakano A. Cardiac origin of smooth muscle cells in the inflow tract. Journal of Molecular and Cellular Cardiology. 50: 337-45. PMID 20974149 DOI: 10.1016/J.Yjmcc.2010.10.009  1
2010 Musunuru K, Domian IJ, Chien KR. Stem cell models of cardiac development and disease. Annual Review of Cell and Developmental Biology. 26: 667-87. PMID 20604707 DOI: 10.1146/Annurev-Cellbio-100109-103948  1
2010 Rodin S, Domogatskaya A, Ström S, Hansson EM, Chien KR, Inzunza J, Hovatta O, Tryggvason K. Long-term self-renewal of human pluripotent stem cells on human recombinant laminin-511. Nature Biotechnology. 28: 611-5. PMID 20512123 DOI: 10.1038/Nbt.1620  1
2010 Bu L, Gao X, Jiang X, Chien KR, Wang Z. Targeted conditional gene knockout in human embryonic stem cells Cell Research. 20: 379-382. PMID 20142843 DOI: 10.1038/Cr.2010.23  1
2010 Yi BA, Wernet O, Chien KR. Pregenerative medicine: developmental paradigms in the biology of cardiovascular regeneration. The Journal of Clinical Investigation. 120: 20-8. PMID 20051633 DOI: 10.1172/Jci40820  1
2010 Knöll R, Kostin S, Klede S, Savvatis K, Klinge L, Stehle I, Gunkel S, Kötter S, Babicz K, Sohns M, Miocic S, Didié M, Knöll G, Zimmermann WH, Thelen P, ... ... Chien KR, et al. A common MLP (muscle LIM protein) variant is associated with cardiomyopathy. Circulation Research. 106: 695-704. PMID 20044516 DOI: 10.1161/Circresaha.109.206243  1
2009 Domian IJ, Chiravuri M, van der Meer P, Feinberg AW, Shi X, Shao Y, Wu SM, Parker KK, Chien KR. Generation of functional ventricular heart muscle from mouse ventricular progenitor cells. Science (New York, N.Y.). 326: 426-9. PMID 19833966 DOI: 10.1126/Science.1177350  1
2009 Hansson EM, Lindsay ME, Chien KR. Regeneration next: toward heart stem cell therapeutics. Cell Stem Cell. 5: 364-77. PMID 19796617 DOI: 10.1016/J.Stem.2009.09.004  1
2009 Andersson KB, Finsen AV, Sjåland C, Winer LH, Sjaastad I, Odegaard A, Louch WE, Wang Y, Chen J, Chien KR, Sejersted OM, Christensen G. Mice carrying a conditional Serca2(flox) allele for the generation of Ca(2+) handling-deficient mouse models. Cell Calcium. 46: 219-25. PMID 19692123 DOI: 10.1016/J.Ceca.2009.07.004  1
2009 Bu L, Jiang X, Martin-Puig S, Caron L, Zhu S, Shao Y, Roberts DJ, Huang PL, Domian IJ, Chien KR. Human ISL1 heart progenitors generate diverse multipotent cardiovascular cell lineages. Nature. 460: 113-7. PMID 19571884 DOI: 10.1038/Nature08191  1
2009 Takeda M, Briggs LE, Wakimoto H, Marks MH, Warren SA, Lu JT, Weinberg EO, Robertson KD, Chien KR, Kasahara H. Slow progressive conduction and contraction defects in loss of Nkx2-5 mice after cardiomyocyte terminal differentiation. Laboratory Investigation; a Journal of Technical Methods and Pathology. 89: 983-93. PMID 19546853 DOI: 10.1038/Labinvest.2009.59  1
2009 Andersson KB, Birkeland JA, Finsen AV, Louch WE, Sjaastad I, Wang Y, Chen J, Molkentin JD, Chien KR, Sejersted OM, Christensen G. Moderate heart dysfunction in mice with inducible cardiomyocyte-specific excision of the Serca2 gene. Journal of Molecular and Cellular Cardiology. 47: 180-7. PMID 19328205 DOI: 10.1016/J.Yjmcc.2009.03.013  1
2009 Risebro CA, Searles RG, Melville AA, Ehler E, Jina N, Shah S, Pallas J, Hubank M, Dillard M, Harvey NL, Schwartz RJ, Chien KR, Oliver G, Riley PR. Prox1 maintains muscle structure and growth in the developing heart. Development (Cambridge, England). 136: 495-505. PMID 19091769 DOI: 10.1242/Dev.030007  1
2009 Risebro CA, Searles RG, Melville AAD, Ehler E, Jina N, Shah S, Pallas J, Hubank M, Dillard M, Harvey NL, Schwartz RJ, Chien KR, Oliver G, Riley PR. Erratum: Prox1 maintains muscle structure and growth in the developing heart (Development (2008) vol. 136 (495-505)) Development. 136. DOI: 10.1242/Dev.034264  1
2009 Chien K. S13-01 Master heart progenitor cells Mechanisms of Development. 126. DOI: 10.1016/J.Mod.2009.06.1024  0.01
2008 Nakano A, Nakano H, Chien KR. Multipotent Islet-1 cardiovascular progenitors in development and disease Cold Spring Harbor Symposia On Quantitative Biology. 73: 297-306. PMID 19204066 DOI: 10.1101/Sqb.2008.73.055  1
2008 Chien KR, Domian IJ, Parker KK. Cardiogenesis and the complex biology of regenerative cardiovascular medicine. Science (New York, N.Y.). 322: 1494-7. PMID 19056974 DOI: 10.1126/Science.1163267  1
2008 Briggs LE, Takeda M, Cuadra AE, Wakimoto H, Marks MH, Walker AJ, Seki T, Oh SP, Lu JT, Sumners C, Raizada MK, Horikoshi N, Weinberg EO, Yasui K, Ikeda Y, ... Chien KR, et al. Perinatal loss of Nkx2-5 results in rapid conduction and contraction defects. Circulation Research. 103: 580-90. PMID 18689573 DOI: 10.1161/Circresaha.108.171835  1
2008 Zhou B, Ma Q, Rajagopal S, Wu SM, Domian I, Rivera-Feliciano J, Jiang D, von Gise A, Ikeda S, Chien KR, Pu WT. Epicardial progenitors contribute to the cardiomyocyte lineage in the developing heart. Nature. 454: 109-13. PMID 18568026 DOI: 10.1038/Nature07060  1
2008 Adams JW, Wang J, Davis JR, Liaw C, Gaidarov I, Gatlin J, Dalton ND, Gu Y, Ross J, Behan D, Chien K, Connolly D. Myocardial expression, signaling, and function of GPR22: a protective role for an orphan G protein-coupled receptor. American Journal of Physiology. Heart and Circulatory Physiology. 295: H509-21. PMID 18539757 DOI: 10.1152/Ajpheart.00368.2008  1
2008 Geier C, Gehmlich K, Ehler E, Hassfeld S, Perrot A, Hayess K, Cardim N, Wenzel K, Erdmann B, Krackhardt F, Posch MG, Osterziel KJ, Bublak A, Nägele H, Scheffold T, ... ... Chien KR, et al. Beyond the sarcomere: CSRP3 mutations cause hypertrophic cardiomyopathy. Human Molecular Genetics. 17: 2753-65. PMID 18505755 DOI: 10.1093/Hmg/Ddn160  1
2008 Chien KR. Regenerative medicine and human models of human disease. Nature. 453: 302-5. PMID 18480810 DOI: 10.1038/Nature07037  0.01
2008 Martin-Puig S, Wang Z, Chien KR. Lives of a Heart Cell: Tracing the Origins of Cardiac Progenitors Cell Stem Cell. 2: 320-331. PMID 18397752 DOI: 10.1016/J.Stem.2008.03.010  1
2008 Wu SM, Chien KR, Mummery C. Origins and fates of cardiovascular progenitor cells. Cell. 132: 537-43. PMID 18295570 DOI: 10.1016/J.Cell.2008.02.002  1
2008 Osafune K, Caron L, Borowiak M, Martinez RJ, Fitz-Gerald CS, Sato Y, Cowan CA, Chien KR, Melton DA. Marked differences in differentiation propensity among human embryonic stem cell lines. Nature Biotechnology. 26: 313-5. PMID 18278034 DOI: 10.1038/Nbt1383  1
2008 Ikeda Y, Hoshijima M, Chien KR. Toward biologically targeted therapy of calcium cycling defects in heart failure. Physiology (Bethesda, Md.). 23: 6-16. PMID 18268360 DOI: 10.1152/Physiol.00033.2007  1
2008 Chan JY, Takeda M, Briggs LE, Graham ML, Lu JT, Horikoshi N, Weinberg EO, Aoki H, Sato N, Chien KR, Kasahara H. Identification of cardiac-specific myosin light chain kinase. Circulation Research. 102: 571-80. PMID 18202317 DOI: 10.1161/Circresaha.107.161687  1
2008 Kaye DM, Hoshijima M, Chien KR. Reversing advanced heart failure by targeting Ca2+ cycling. Annual Review of Medicine. 59: 13-28. PMID 18186701 DOI: 10.1146/Annurev.Med.59.052407.103237  1
2008 Laugwitz KL, Moretti A, Caron L, Nakano A, Chien KR. Islet1 cardiovascular progenitors: a single source for heart lineages? Development (Cambridge, England). 135: 193-205. PMID 18156162 DOI: 10.1242/Dev.001883  1
2008 Amand TRS, Lu JT, Chien KR. Defects in cardiac conduction system lineages and malignant arrhythmias: developmental pathways and disease. Novartis Foundation Symposium. 250: 260-275. DOI: 10.1002/0470868066.Ch16  1
2007 Qyang Y, Martin-Puig S, Chiravuri M, Chen S, Xu H, Bu L, Jiang X, Lin L, Granger A, Moretti A, Caron L, Wu X, Clarke J, Taketo MM, Laugwitz KL, ... ... Chien KR, et al. The renewal and differentiation of Isl1+ cardiovascular progenitors are controlled by a Wnt/beta-catenin pathway. Cell Stem Cell. 1: 165-79. PMID 18371348 DOI: 10.1016/J.Stem.2007.05.018  1
2007 Yamamoto R, Akazawa H, Ito K, Toko H, Sano M, Yasuda N, Qin Y, Kudo Y, Sugaya T, Chien KR, Komuro I. Angiotensin II type 1a receptor signals are involved in the progression of heart failure in MLP-deficient mice. Circulation Journal : Official Journal of the Japanese Circulation Society. 71: 1958-64. PMID 18037754 DOI: 10.1253/Circj.71.1958  0.01
2007 Knöll R, Postel R, Wang J, Krätzner R, Hennecke G, Vacaru AM, Vakeel P, Schubert C, Murthy K, Rana BK, Kube D, Knöll G, Schäfer K, Hayashi T, Holm T, ... ... Chien KR, et al. Laminin-alpha4 and integrin-linked kinase mutations cause human cardiomyopathy via simultaneous defects in cardiomyocytes and endothelial cells. Circulation. 116: 515-25. PMID 17646580 DOI: 10.1161/Circulationaha.107.689984  1
2007 Kaye DM, Preovolos A, Marshall T, Byrne M, Hoshijima M, Hajjar R, Mariani JA, Pepe S, Chien KR, Power JM. Percutaneous cardiac recirculation-mediated gene transfer of an inhibitory phospholamban peptide reverses advanced heart failure in large animals. Journal of the American College of Cardiology. 50: 253-60. PMID 17631218 DOI: 10.1016/J.Jacc.2007.03.047  1
2007 Hirai M, Horiguchi M, Ohbayashi T, Kita T, Chien KR, Nakamura T. Latent TGF-beta-binding protein 2 binds to DANCE/fibulin-5 and regulates elastic fiber assembly. The Embo Journal. 26: 3283-95. PMID 17581631 DOI: 10.1038/Sj.Emboj.7601768  1
2007 Chien KR. Molecular medicine: microRNAs and the tell-tale heart. Nature. 447: 389-90. PMID 17522664 DOI: 10.1038/447389A  0.01
2007 Smart N, Risebro CA, Melville AA, Moses K, Schwartz RJ, Chien KR, Riley PR. Thymosin beta-4 is essential for coronary vessel development and promotes neovascularization via adult epicardium. Annals of the New York Academy of Sciences. 1112: 171-88. PMID 17495252 DOI: 10.1016/J.Yjmcc.2007.03.685  1
2007 Hirai M, Ohbayashi T, Horiguchi M, Okawa K, Hagiwara A, Chien KR, Kita T, Nakamura T. Fibulin-5/DANCE has an elastogenic organizer activity that is abrogated by proteolytic cleavage in vivo. The Journal of Cell Biology. 176: 1061-71. PMID 17371835 DOI: 10.1083/Jcb.200611026  1
2007 Prall OW, Menon MK, Solloway MJ, Watanabe Y, Zaffran S, Bajolle F, Biben C, McBride JJ, Robertson BR, Chaulet H, Stennard FA, Wise N, Schaft D, Wolstein O, Furtado MB, ... ... Chien KR, et al. An Nkx2-5/Bmp2/Smad1 negative feedback loop controls heart progenitor specification and proliferation. Cell. 128: 947-59. PMID 17350578 DOI: 10.1016/J.Cell.2007.01.042  1
2007 Pomiès P, Pashmforoush M, Vegezzi C, Chien KR, Auffray C, Beckerle MC. The cytoskeleton-associated PDZ-LIM protein, ALP, acts on serum response factor activity to regulate muscle differentiation. Molecular Biology of the Cell. 18: 1723-33. PMID 17332502 DOI: 10.1091/Mbc.E06-09-0815  1
2007 Teutsch C, Kondo RP, Dederko DA, Chrast J, Chien KR, Giles WR. Spatial distributions of Kv4 channels and KChip2 isoforms in the murine heart based on laser capture microdissection. Cardiovascular Research. 73: 739-49. PMID 17289005 DOI: 10.1016/J.Cardiores.2006.11.034  0.01
2007 Muller O, Pradervand S, Berger S, Centeno G, Milet A, Nicod P, Pedrazzini T, Tronche F, Schütz G, Chien K, Rossier BC, Firsov D. Identification of corticosteroid-regulated genes in cardiomyocytes by serial analysis of gene expression. Genomics. 89: 370-7. PMID 17174066 DOI: 10.1016/J.Ygeno.2006.11.001  1
2007 Smart N, Risebro CA, Melville AA, Moses K, Schwartz RJ, Chien KR, Riley PR. Thymosin beta4 induces adult epicardial progenitor mobilization and neovascularization. Nature. 445: 177-82. PMID 17108969 DOI: 10.1038/Nature05383  1
2007 Andersson KB, Finsen AV, Sjaastad I, Wang Y, Chen J, Molkentin JD, Chien KR, Sejersted OM, Christensen G. WITHDRAWN: Heart function in adult cardiac Serca2null mice Journal of Molecular and Cellular Cardiology. DOI: 10.1016/J.Yjmcc.2007.03.841  1
2006 Moretti A, Caron L, Nakano A, Lam JT, Bernshausen A, Chen Y, Qyang Y, Bu L, Sasaki M, Martin-Puig S, Sun Y, Evans SM, Laugwitz KL, Chien KR. Multipotent embryonic isl1+ progenitor cells lead to cardiac, smooth muscle, and endothelial cell diversification. Cell. 127: 1151-65. PMID 17123592 DOI: 10.1016/J.Cell.2006.10.029  1
2006 Yajima T, Yasukawa H, Jeon ES, Xiong D, Dorner A, Iwatate M, Nara M, Zhou H, Summers-Torres D, Hoshijima M, Chien KR, Yoshimura A, Knowlton KU. Innate defense mechanism against virus infection within the cardiac myocyte requiring gp130-STAT3 signaling. Circulation. 114: 2364-73. PMID 17101849 DOI: 10.1161/Circulationaha.106.642454  1
2006 Hoshijima M, Knöll R, Pashmforoush M, Chien KR. Reversal of calcium cycling defects in advanced heart failure toward molecular therapy. Journal of the American College of Cardiology. 48: A15-23. PMID 17084280 DOI: 10.1016/J.Jacc.2006.06.070  1
2006 Chien KR. Beyond small molecule drugs for heart failure: prospects for gene therapy. Novartis Foundation Symposium. 274: 244-56; discussion 2. PMID 17019816 DOI: 10.1002/0470029331.Ch15  0.01
2006 Weissgerber P, Held B, Bloch W, Kaestner L, Chien KR, Fleischmann BK, Lipp P, Flockerzi V, Freichel M. Reduced cardiac L-type Ca2+ current in Ca(V)beta2-/- embryos impairs cardiac development and contraction with secondary defects in vascular maturation. Circulation Research. 99: 749-57. PMID 16946137 DOI: 10.1161/01.Res.0000243978.15182.C1  1
2006 Ricote M, Snyder CS, Leung HY, Chen J, Chien KR, Glass CK. Normal hematopoiesis after conditional targeting of RXRalpha in murine hematopoietic stem/progenitor cells. Journal of Leukocyte Biology. 80: 850-61. PMID 16888087 DOI: 10.1189/Jlb.0206097  1
2006 Chien KR. Lost and found: cardiac stem cell therapy revisited. The Journal of Clinical Investigation. 116: 1838-40. PMID 16823485 DOI: 10.1172/Jci29050  0.01
2006 Chien KR. Herceptin and the heart--a molecular modifier of cardiac failure. The New England Journal of Medicine. 354: 789-90. PMID 16495390 DOI: 10.1056/Nejmp058315  0.01
2006 St Amand TR, Lu JT, Zamora M, Gu Y, Stricker J, Hoshijima M, Epstein JA, Ross JJ, Ruiz-Lozano P, Chien KR. Distinct roles of HF-1b/Sp4 in ventricular and neural crest cells lineages affect cardiac conduction system development. Developmental Biology. 291: 208-17. PMID 16430881 DOI: 10.1016/J.Ydbio.2005.10.018  1
2006 Peng X, Kraus MS, Wei H, Shen TL, Pariaut R, Alcaraz A, Ji G, Cheng L, Yang Q, Kotlikoff MI, Chen J, Chien K, Gu H, Guan JL. Inactivation of focal adhesion kinase in cardiomyocytes promotes eccentric cardiac hypertrophy and fibrosis in mice. The Journal of Clinical Investigation. 116: 217-27. PMID 16374517 DOI: 10.1172/Jci24497  1
2006 Kondo RP, Dederko DA, Teutsch C, Chrast J, Catalucci D, Chien KR, Giles WR. Comparison of contraction and calcium handling between right and left ventricular myocytes from adult mouse heart: a role for repolarization waveform. The Journal of Physiology. 571: 131-46. PMID 16357014 DOI: 10.1113/Jphysiol.2005.101428  0.01
2006 Wang J, Hoshijima M, Lam J, Zhou Z, Jokiel A, Dalton ND, Hultenby K, Ruiz-Lozano P, Ross J, Tryggvason K, Chien KR. Cardiomyopathy associated with microcirculation dysfunction in laminin alpha4 chain-deficient mice. The Journal of Biological Chemistry. 281: 213-20. PMID 16204254 DOI: 10.1074/Jbc.M505061200  1
2005 Merki E, Zamora M, Raya A, Kawakami Y, Wang J, Zhang X, Burch J, Kubalak SW, Kaliman P, Izpisua Belmonte JC, Chien KR, Ruiz-Lozano P. Epicardial retinoid X receptor alpha is required for myocardial growth and coronary artery formation. Proceedings of the National Academy of Sciences of the United States of America. 102: 18455-60. PMID 16352730 DOI: 10.1073/Pnas.0504343102  1
2005 Lorenzen-Schmidt I, Stuyvers BD, ter Keurs HE, Date MO, Hoshijima M, Chien KR, McCulloch AD, Omens JH. Young MLP deficient mice show diastolic dysfunction before the onset of dilated cardiomyopathy. Journal of Molecular and Cellular Cardiology. 39: 241-50. PMID 15978612 DOI: 10.1016/J.Yjmcc.2005.05.006  1
2005 Chien KR. Alchemy and the new age of cardiac muscle cell biology. Plos Biology. 3: e131. PMID 15819607 DOI: 10.1371/Journal.Pbio.0030131  0.01
2005 Chien KR, Karsenty G. Longevity and lineages: toward the integrative biology of degenerative diseases in heart, muscle, and bone. Cell. 120: 533-44. PMID 15734685 DOI: 10.1016/J.Cell.2005.02.006  0.01
2005 Laugwitz KL, Moretti A, Lam J, Gruber P, Chen Y, Woodard S, Lin LZ, Cai CL, Lu MM, Reth M, Platoshyn O, Yuan JX, Evans S, Chien KR. Postnatal isl1+ cardioblasts enter fully differentiated cardiomyocyte lineages. Nature. 433: 647-53. PMID 15703750 DOI: 10.1038/Nature03215  1
2005 Kaliman P, Catalucci D, Lam JT, Kondo R, Gutiérrez JC, Reddy S, Palacín M, Zorzano A, Chien KR, Ruiz-Lozano P. Myotonic dystrophy protein kinase phosphorylates phospholamban and regulates calcium uptake in cardiomyocyte sarcoplasmic reticulum. The Journal of Biological Chemistry. 280: 8016-21. PMID 15598648 DOI: 10.1074/Jbc.M412845200  1
2005 Zhou X, Long JM, Geyer MA, Masliah E, Kelsoe JR, Wynshaw-Boris A, Chien KR. Reduced expression of the Sp4 gene in mice causes deficits in sensorimotor gating and memory associated with hippocampal vacuolization. Molecular Psychiatry. 10: 393-406. PMID 15558077 DOI: 10.1038/Sj.Mp.4001621  1
2005 Kaye DM, Chien K, Hoshijima M, Zsebo K, Power J. 41. High Efficiency, Catheter-Based, Gene Transfer to the Large Animal Heart Molecular Therapy. 11. DOI: 10.1016/J.Ymthe.2005.06.069  1
2004 Hayashi T, Arimura T, Itoh-Satoh M, Ueda K, Hohda S, Inagaki N, Takahashi M, Hori H, Yasunami M, Nishi H, Koga Y, Nakamura H, Matsuzaki M, Choi BY, Bae SW, ... ... Chien KR, et al. Tcap gene mutations in hypertrophic cardiomyopathy and dilated cardiomyopathy. Journal of the American College of Cardiology. 44: 2192-201. PMID 15582318 DOI: 10.1016/J.Jacc.2004.08.058  1
2004 Nishida K, Yamaguchi O, Hirotani S, Hikoso S, Higuchi Y, Watanabe T, Takeda T, Osuka S, Morita T, Kondoh G, Uno Y, Kashiwase K, Taniike M, Nakai A, Matsumura Y, ... ... Chien KR, et al. p38alpha mitogen-activated protein kinase plays a critical role in cardiomyocyte survival but not in cardiac hypertrophic growth in response to pressure overload. Molecular and Cellular Biology. 24: 10611-20. PMID 15572667 DOI: 10.1128/Mcb.24.24.10611-10620.2004  0.01
2004 Minamisawa S, Oshikawa J, Takeshima H, Hoshijima M, Wang Y, Chien KR, Ishikawa Y, Matsuoka R. Junctophilin type 2 is associated with caveolin-3 and is down-regulated in the hypertrophic and dilated cardiomyopathies Biochemical and Biophysical Research Communications. 325: 852-856. PMID 15541368 DOI: 10.1016/J.Bbrc.2004.10.107  1
2004 Pradervand S, Yasukawa H, Muller OG, Kjekshus H, Nakamura T, St Amand TR, Yajima T, Matsumura K, Duplain H, Iwatate M, Woodard S, Pedrazzini T, Ross J, Firsov D, Rossier BC, ... ... Chien KR, et al. Small proline-rich protein 1A is a gp130 pathway- and stress-inducible cardioprotective protein. The Embo Journal. 23: 4517-25. PMID 15510217 DOI: 10.1038/Sj.Emboj.7600454  1
2004 Conrad M, Jakupoglu C, Moreno SG, Lippl S, Banjac A, Schneider M, Beck H, Hatzopoulos AK, Just U, Sinowatz F, Schmahl W, Chien KR, Wurst W, Bornkamm GW, Brielmeier M. Essential role for mitochondrial thioredoxin reductase in hematopoiesis, heart development, and heart function. Molecular and Cellular Biology. 24: 9414-23. PMID 15485910 DOI: 10.1128/Mcb.24.21.9414-9423.2004  0.01
2004 Chien KR, Moretti A, Laugwitz KL. Development. ES cells to the rescue. Science (New York, N.Y.). 306: 239-40. PMID 15472069 DOI: 10.1126/Science.1104769  1
2004 Yamaguchi O, Watanabe T, Nishida K, Kashiwase K, Higuchi Y, Takeda T, Hikoso S, Hirotani S, Asahi M, Taniike M, Nakai A, Tsujimoto I, Matsumura Y, Miyazaki J, Chien KR, et al. Cardiac-specific disruption of the c-raf-1 gene induces cardiac dysfunction and apoptosis. The Journal of Clinical Investigation. 114: 937-43. PMID 15467832 DOI: 10.1172/Jci20317  0.01
2004 Chien KR, Hoshijima M. Unravelling Ras signals in cardiovascular disease. Nature Cell Biology. 6: 807-8. PMID 15340447 DOI: 10.1038/Ncb0904-807  1
2004 Smith RM, Suleman N, Lacerda L, Opie LH, Akira S, Chien KR, Sack MN. Genetic depletion of cardiac myocyte STAT-3 abolishes classical preconditioning. Cardiovascular Research. 63: 611-6. PMID 15306216 DOI: 10.1016/J.Cardiores.2004.06.019  0.01
2004 Carrier L, Knöll R, Vignier N, Keller DI, Bausero P, Prudhon B, Isnard R, Ambroisine ML, Fiszman M, Ross J, Schwartz K, Chien KR. Asymmetric septal hypertrophy in heterozygous cMyBP-C null mice. Cardiovascular Research. 63: 293-304. PMID 15249187 DOI: 10.1016/J.Cardiores.2004.04.009  1
2004 Mori H, Hanada R, Hanada T, Aki D, Mashima R, Nishinakamura H, Torisu T, Chien KR, Yasukawa H, Yoshimura A. Socs3 deficiency in the brain elevates leptin sensitivity and confers resistance to diet-induced obesity. Nature Medicine. 10: 739-43. PMID 15208705 DOI: 10.1038/Nm1071  1
2004 Pashmforoush M, Lu JT, Chen H, Amand TS, Kondo R, Pradervand S, Evans SM, Clark B, Feramisco JR, Giles W, Ho SY, Benson DW, Silberbach M, Shou W, Chien KR. Nkx2-5 pathways and congenital heart disease; loss of ventricular myocyte lineage specification leads to progressive cardiomyopathy and complete heart block. Cell. 117: 373-86. PMID 15109497 DOI: 10.1016/S0092-8674(04)00405-2  1
2004 Chen H, Shi S, Acosta L, Li W, Lu J, Bao S, Chen Z, Yang Z, Schneider MD, Chien KR, Conway SJ, Yoder MC, Haneline LS, Franco D, Shou W. BMP10 is essential for maintaining cardiac growth during murine cardiogenesis. Development (Cambridge, England). 131: 2219-31. PMID 15073151 DOI: 10.1242/Dev.01094  1
2004 Chien KR. Stem cells: lost in translation. Nature. 428: 607-8. PMID 15034595 DOI: 10.1038/Nature02500  0.01
2004 Chien K, Chien L. The new Silk Road Nature. 428: 208-209. PMID 15014508 DOI: 10.1038/428208A  1
2004 Iwanaga Y, Hoshijima M, Gu Y, Iwatate M, Dieterle T, Ikeda Y, Date MO, Chrast J, Matsuzaki M, Peterson KL, Chien KR, Ross J. Chronic phospholamban inhibition prevents progressive cardiac dysfunction and pathological remodeling after infarction in rats. The Journal of Clinical Investigation. 113: 727-36. PMID 14991071 DOI: 10.1172/Jci18716  1
2004 Bale TL, Hoshijima M, Gu Y, Dalton N, Anderson KR, Lee KF, Rivier J, Chien KR, Vale WW, Peterson KL. The cardiovascular physiologic actions of urocortin II: acute effects in murine heart failure. Proceedings of the National Academy of Sciences of the United States of America. 101: 3697-702. PMID 14990799 DOI: 10.1073/Pnas.0307324101  1
2004 Zheng M, Dilly K, Dos Santos Cruz J, Li M, Gu Y, Ursitti JA, Chen J, Ross J, Chien KR, Lederer JW, Wang Y. Sarcoplasmic reticulum calcium defect in Ras-induced hypertrophic cardiomyopathy heart American Journal of Physiology - Heart and Circulatory Physiology. 286: H424-H433. PMID 12969887 DOI: 10.1152/Ajpheart.00110.2003  1
2004 Gourdie RG, Kubalak SW, O'Brien TX, Chien KR, Mikawa T. Development of Cardiac Pacemaking and Conduction System Lineages Molecular Basis of Cardiovascular Disease: a Companion to Braunwald's Heart Disease. 225-237. DOI: 10.1016/B978-0-7216-9428-3.50016-0  1
2003 Knöll R, Hoshijima M, Chien K. Cardiac mechanotransduction and implications for heart disease. Journal of Molecular Medicine (Berlin, Germany). 81: 750-6. PMID 14551702 DOI: 10.1007/S00109-003-0488-X  1
2003 Iwatate M, Gu Y, Dieterle T, Iwanaga Y, Peterson KL, Hoshijima M, Chien KR, Ross J. In vivo high-efficiency transcoronary gene delivery and Cre-LoxP gene switching in the adult mouse heart. Gene Therapy. 10: 1814-20. PMID 12960971 DOI: 10.1038/Sj.Gt.3302077  1
2003 Minamisawa S, Wang Y, Chen J, Ishikawa Y, Chien KR, Matsuoka R. Atrial chamber-specific expression of sarcolipin is regulated during development and hypertrophic remodeling Journal of Biological Chemistry. 278: 9570-9575. PMID 12645548 DOI: 10.1074/Jbc.M213132200  1
2003 Yasukawa H, Yajima T, Duplain H, Iwatate M, Kido M, Hoshijima M, Weitzman MD, Nakamura T, Woodard S, Xiong D, Yoshimura A, Chien KR, Knowlton KU. The suppressor of cytokine signaling-1 (SOCS1) is a novel therapeutic target for enterovirus-induced cardiac injury. The Journal of Clinical Investigation. 111: 469-78. PMID 12588885 DOI: 10.1172/Jci16491  1
2003 Gopalan SM, Flaim C, Bhatia SN, Hoshijima M, Knoell R, Chien KR, Omens JH, McCulloch AD. Anisotropic stretch-induced hypertrophy in neonatal ventricular myocytes micropatterned on deformable elastomers. Biotechnology and Bioengineering. 81: 578-87. PMID 12514807 DOI: 10.1002/Bit.10506  1
2003 Ludwig A, Budde T, Stieber J, Moosmang S, Wahl C, Holthoff K, Langebartels A, Wotjak C, Munsch T, Zong X, Feil S, Feil R, Lancel M, Chien KR, Konnerth A, et al. Absence epilepsy and sinus dysrhythmia in mice lacking the pacemaker channel HCN2. The Embo Journal. 22: 216-24. PMID 12514127 DOI: 10.1093/Emboj/Cdg032  1
2002 Knöll R, Hoshijima M, Hoffman HM, Person V, Lorenzen-Schmidt I, Bang ML, Hayashi T, Shiga N, Yasukawa H, Schaper W, McKenna W, Yokoyama M, Schork NJ, Omens JH, McCulloch AD, ... ... Chien KR, et al. The cardiac mechanical stretch sensor machinery involves a Z disc complex that is defective in a subset of human dilated cardiomyopathy. Cell. 111: 943-55. PMID 12507422 DOI: 10.1016/S0092-8674(02)01226-6  1
2002 Hamblet NS, Lijam N, Ruiz-Lozano P, Wang J, Yang Y, Luo Z, Mei L, Chien KR, Sussman DJ, Wynshaw-Boris A. Dishevelled 2 is essential for cardiac outflow tract development, somite segmentation and neural tube closure. Development (Cambridge, England). 129: 5827-38. PMID 12421720 DOI: 10.1242/Dev.00164  1
2002 Jiang X, Choudhary B, Merki E, Chien KR, Maxson RE, Sucov HM. Normal fate and altered function of the cardiac neural crest cell lineage in retinoic acid receptor mutant embryos. Mechanisms of Development. 117: 115-22. PMID 12204252 DOI: 10.1016/S0925-4773(02)00206-X  1
2002 Zhao YY, Liu Y, Stan RV, Fan L, Gu Y, Dalton N, Chu PH, Peterson K, Ross J, Chien KR. Defects in caveolin-1 cause dilated cardiomyopathy and pulmonary hypertension in knockout mice Proceedings of the National Academy of Sciences of the United States of America. 99: 11375-11380. PMID 12177436 DOI: 10.1073/Pnas.172360799  1
2002 Ozcelik C, Erdmann B, Pilz B, Wettschureck N, Britsch S, Hübner N, Chien KR, Birchmeier C, Garratt AN. Conditional mutation of the ErbB2 (HER2) receptor in cardiomyocytes leads to dilated cardiomyopathy. Proceedings of the National Academy of Sciences of the United States of America. 99: 8880-5. PMID 12072561 DOI: 10.1073/Pnas.122249299  1
2002 Crone SA, Zhao YY, Fan L, Gu Y, Minamisawa S, Liu Y, Peterson KL, Chen J, Kahn R, Condorelli G, Ross J, Chien KR, Lee KF. ErbB2 is essential in the prevention of dilated cardiomyopathy. Nature Medicine. 8: 459-65. PMID 11984589 DOI: 10.1038/Nm0502-459  1
2002 Ikeda Y, Gu Y, Iwanaga Y, Hoshijima M, Oh SS, Giordano FJ, Chen J, Nigro V, Peterson KL, Chien KR, Ross J. Restoration of deficient membrane proteins in the cardiomyopathic hamster by in vivo cardiac gene transfer. Circulation. 105: 502-8. PMID 11815435 DOI: 10.1161/Hc0402.102953  1
2002 Nakamura T, Lozano PR, Ikeda Y, Iwanaga Y, Hinek A, Minamisawa S, Cheng CF, Kobuke K, Dalton N, Takada Y, Tashiro K, Ross Jr J, Honjo T, Chien KR. Fibulin-5/DANCE is essential for elastogenesis in vivo. Nature. 415: 171-5. PMID 11805835 DOI: 10.1038/415171A  1
2001 Yasukawa H, Hoshijima M, Gu Y, Nakamura T, Pradervand S, Hanada T, Hanakawa Y, Yoshimura A, Ross J, Chien KR. Suppressor of cytokine signaling-3 is a biomechanical stress-inducible gene that suppresses gp130-mediated cardiac myocyte hypertrophy and survival pathways. The Journal of Clinical Investigation. 108: 1459-67. PMID 11714737 DOI: 10.1172/Jci13939  1
2001 Wettschureck N, Rütten H, Zywietz A, Gehring D, Wilkie TM, Chen J, Chien KR, Offermanns S. Absence of pressure overload induced myocardial hypertrophy after conditional inactivation of Gαq/Gα11 in cardiomyocytes Nature Medicine. 7: 1236-1240. PMID 11689889 DOI: 10.1038/Nm1101-1236  1
2001 Williams SP, Gerber HP, Giordano FJ, Peale FV, Bernstein LJ, Bunting S, Chien KR, Ferrara N, van Bruggen N. Dobutamine stress cine-MRI of cardiac function in the hearts of adult cardiomyocyte-specific VEGF knockout mice. Journal of Magnetic Resonance Imaging : Jmri. 14: 374-82. PMID 11599061 DOI: 10.1002/Jmri.1197  1
2001 Liao P, Georgakopoulos D, Kovacs A, Zheng M, Lerner D, Pu H, Saffitz J, Chien K, Xiao RP, Kass DA, Wang Y. The in vivo role of p38 MAP kinases in cardiac remodeling and restrictive cardiomyopathy Proceedings of the National Academy of Sciences of the United States of America. 98: 12283-12288. PMID 11593045 DOI: 10.1073/Pnas.211086598  1
2001 Su Z, Yao A, Zubair I, Sugishita K, Ritter M, Li F, Hunter JJ, Chien KR, Barry WH. Effects of deletion of muscle LIM protein on myocyte function. American Journal of Physiology. Heart and Circulatory Physiology. 280: H2665-73. PMID 11356623 DOI: 10.1152/Ajpheart.2001.280.6.H2665  1
2001 Giordano FJ, Gerber HP, Williams SP, VanBruggen N, Bunting S, Ruiz-Lozano P, Gu Y, Nath AK, Huang Y, Hickey R, Dalton N, Peterson KL, Ross J, Chien KR, Ferrara N. A cardiac myocyte vascular endothelial growth factor paracrine pathway is required to maintain cardiac function. Proceedings of the National Academy of Sciences of the United States of America. 98: 5780-5. PMID 11331753 DOI: 10.1073/Pnas.091415198  1
2001 Pashmforoush M, Pomiès P, Peterson KL, Kubalak S, Ross J, Hefti A, Aebi U, Beckerle MC, Chien KR. Adult mice deficient in actinin-associated LIM-domain protein reveal a developmental pathway for right ventricular cardiomyopathy. Nature Medicine. 7: 591-7. PMID 11329061 DOI: 10.1038/87920  1
2000 Hongo M, Ryoke T, Schoenfeld J, Hunter J, Dalton N, Clark R, Lowe D, Chien K, Ross J. Effects of growth hormone on cardiac dysfunction and gene expression in genetic murine dilated cardiomyopathy. Basic Research in Cardiology. 95: 431-441. PMID 11192363 DOI: 10.1007/S003950070018  1
2000 Nguyên-Trân VT, Kubalak SW, Minamisawa S, Fiset C, Wollert KC, Brown AB, Ruiz-Lozano P, Barrere-Lemaire S, Kondo R, Norman LW, Gourdie RG, Rahme MM, Feld GK, Clark RB, Giles WR, ... Chien KR, et al. A novel genetic pathway for sudden cardiac death via defects in the transition between ventricular and conduction system cell lineages. Cell. 102: 671-82. PMID 11007485 DOI: 10.1016/S0092-8674(00)00089-1  1
2000 Hart A, Melet F, Grossfeld P, Chien K, Jones C, Tunnacliffe A, Favier R, Bernstein A. Fli-1 is required for murine vascular and megakaryocytic development and is hemizygously deleted in patients with thrombocytopenia Immunity. 13: 167-177. PMID 10981960 DOI: 10.1016/S1074-7613(00)00017-0  1
2000 Wan YJ, An D, Cai Y, Repa JJ, Hung-Po Chen T, Flores M, Postic C, Magnuson MA, Chen J, Chien KR, French S, Mangelsdorf DJ, Sucov HM. Hepatocyte-specific mutation establishes retinoid X receptor alpha as a heterodimeric integrator of multiple physiological processes in the liver. Molecular and Cellular Biology. 20: 4436-44. PMID 10825207 DOI: 10.1128/Mcb.20.12.4436-4444.2000  1
2000 Doevendans PA, Kubalak SW, An RH, Becker DK, Chien KR, Kass RS. Differentiation of cardiomyocytes in floating embryoid bodies is comparable to fetal cardiomyocytes. Journal of Molecular and Cellular Cardiology. 32: 839-51. PMID 10775488 DOI: 10.1006/Jmcc.2000.1128  1
2000 Jones C, Müllenbach R, Grossfeld P, Auer R, Favier R, Chien K, James M, Tunnacliffe A, Cotter F. Co-localisation of CCG repeats and chromosome deletion breakpoints in Jacobsen syndrome: evidence for a common mechanism of chromosome breakage Human Molecular Genetics. 9: 1201-1208. PMID 10767345 DOI: 10.1093/Hmg/9.8.1201  1
2000 Chien KR. Mentors for the New Millennium Advice to a Young Cardiologist Circulation. 101: 1616-1618. PMID 10747357 DOI: 10.1161/01.Cir.101.13.1616  0.01
1999 Minamisawa S, Hoshijima M, Chu G, Ward CA, Frank K, Gu Y, Martone ME, Wang Y, Ross J, Kranias EG, Giles WR, Chien KR. Chronic phospholamban-sarcoplasmic reticulum calcium ATPase interaction is the critical calcium cycling defect in dilated cardiomyopathy. Cell. 99: 313-22. PMID 10555147 DOI: 10.1016/S0092-8674(00)81662-1  1
1999 Barak Y, Nelson MC, Ong ES, Jones YZ, Ruiz-Lozano P, Chien KR, Koder A, Evans RM. PPAR gamma is required for placental, cardiac, and adipose tissue development. Molecular Cell. 4: 585-95. PMID 10549290 DOI: 10.1016/S1097-2765(00)80209-9  1
1999 Tsukui T, Capdevila J, Tamura K, Ruiz-Lozano P, Rodriguez-Esteban C, Yonei-Tamura S, Magallón J, Chandraratna RA, Chien K, Blumberg B, Evans RM, Belmonte JC. Multiple left-right asymmetry defects in Shh(-/-) mutant mice unveil a convergence of the shh and retinoic acid pathways in the control of Lefty-1. Proceedings of the National Academy of Sciences of the United States of America. 96: 11376-81. PMID 10500184 DOI: 10.1073/Pnas.96.20.11376  1
1999 Marszalek JR, Ruiz-Lozano P, Roberts E, Chien KR, Goldstein LS. Situs inversus and embryonic ciliary morphogenesis defects in mouse mutants lacking the KIF3A subunit of kinesin-II. Proceedings of the National Academy of Sciences of the United States of America. 96: 5043-8. PMID 10220415 DOI: 10.1073/Pnas.96.9.5043  1
1998 Liu X, Hwang H, Cao L, Buckland M, Cunningham A, Chen J, Chien KR, Graham RM, Zhou M. Domain-specific gene disruption reveals critical regulation of neuregulin signaling by its cytoplasmic tail. Proceedings of the National Academy of Sciences of the United States of America. 95: 13024-9. PMID 9789034 DOI: 10.1073/Pnas.95.22.13024  1
1998 Hongo M, Sentianin EM, Tanaka N, Mao L, McKirnan MD, Clark RG, Won W, Chien KR, Ross J. Angiotensin II blockade followed by growth hormone as adjunctive therapy after experimental myocardial infarction. Journal of Cardiac Failure. 4: 213-24. PMID 9754592 DOI: 10.1016/S1071-9164(98)80008-0  1
1998 Adams JW, Sakata Y, Davis MG, Sah VP, Wang Y, Liggett SB, Chien KR, Brown JH, Dorn GW. Enhanced Galphaq signaling: a common pathway mediates cardiac hypertrophy and apoptotic heart failure. Proceedings of the National Academy of Sciences of the United States of America. 95: 10140-5. PMID 9707614 DOI: 10.1073/Pnas.95.17.10140  1
1998 Rockman HA, Chien KR, Choi DJ, Iaccarino G, Hunter JJ, Ross J, Lefkowitz RJ, Koch WJ. Expression of a beta-adrenergic receptor kinase 1 inhibitor prevents the development of myocardial failure in gene-targeted mice. Proceedings of the National Academy of Sciences of the United States of America. 95: 7000-5. PMID 9618528 DOI: 10.1073/Pnas.95.12.7000  1
1998 Hoshijima M, Sah VP, Wang Y, Chien KR, Brown JH. The low molecular weight GTPase Rho regulates myofibril formation and organization in neonatal rat ventricular myocytes. Involvement of Rho kinase. The Journal of Biological Chemistry. 273: 7725-30. PMID 9516480 DOI: 10.1074/Jbc.273.13.7725  1
1998 Wang Y, Su B, Sah VP, Brown JH, Han J, Chien KR. Cardiac hypertrophy induced by mitogen-activated protein kinase kinase 7, a specific activator for c-Jun NH2-terminal kinase in ventricular muscle cells. The Journal of Biological Chemistry. 273: 5423-6. PMID 9488659 DOI: 10.1074/Jbc.273.10.5423  1
1998 Wang Y, Huang S, Sah VP, Ross J, Brown JH, Han J, Chien KR. Cardiac muscle cell hypertrophy and apoptosis induced by distinct members of the p38 mitogen-activated protein kinase family. The Journal of Biological Chemistry. 273: 2161-8. PMID 9442057 DOI: 10.1074/Jbc.273.4.2161  1
1997 Harris AN, Ruiz-Lozano P, Chen YF, Sionit P, Yu YT, Lilly B, Olson EN, Chien KR. A novel A/T-rich element mediates ANF gene expression during cardiac myocyte hypertrophy. Journal of Molecular and Cellular Cardiology. 29: 515-25. PMID 9140811 DOI: 10.1006/Jmcc.1996.0295  1
1997 Chien KR, Shimizu M, Hoshijima M, Minamisawa S, Grace AA. Toward molecular strategies for heart disease--past, present, future. Japanese Circulation Journal. 61: 91-118. PMID 9070966 DOI: 10.1253/Jcj.61.91  1
1997 Cohn JN, Bristow MR, Chien KR, Colucci WS, Frazier OH, Leinwand LA, Lorell BH, Moss AJ, Sonnenblick EH, Walsh RA, Mockrin SC, Reinlib L. Report of the National Heart, Lung, and Blood Institute special emphasis panel on heart failure research Circulation. 95: 766-770. PMID 9054723 DOI: 10.1161/01.Cir.95.4.766  1
1997 Arber S, Hunter JJ, Ross J, Hongo M, Sansig G, Borg J, Perriard JC, Chien KR, Caroni P. MLP-deficient mice exhibit a disruption of cardiac cytoarchitectural organization, dilated cardiomyopathy, and heart failure. Cell. 88: 393-403. PMID 9039266 DOI: 10.1016/S0092-8674(00)81878-4  1
1996 Lembo G, Rockman HA, Hunter JJ, Steinmetz H, Koch WJ, Ma L, Prinz MP, Ross J, Chien KR, Powell-Braxton L. Elevated blood pressure and enhanced myocardial contractility in mice with severe IGF-1 deficiency Journal of Clinical Investigation. 98: 2648-2655. PMID 8958230 DOI: 10.1172/Jci119086  1
1996 Gruber PJ, Kubalak SW, Pexieder T, Sucov HM, Evans RM, Chien KR. RXRα deficiency confers genetic susceptibility for aortic sac, conotruncal, atrioventricular cushion, and ventricular muscle defects in mice Journal of Clinical Investigation. 98: 1332-1343. PMID 8823298 DOI: 10.1172/Jci118920  1
1996 Tanaka N, Dalton N, Mao L, Rockman HA, Peterson KL, Gottshall KR, Hunter JJ, Chien KR, Ross J. Transthoracic echocardiography in models of cardiac disease in the mouse Circulation. 94: 1109-1117. PMID 8790053 DOI: 10.1161/01.Cir.94.5.1109  1
1996 Engelmann GL, Worrell RA, Duff RA, Grutkoski PS, Chien KR, Harvey RP. Expression of cardiac muscle markers in rat myocyte cell lines. Molecular and Cellular Biochemistry. 157: 87-91. PMID 8739232 DOI: 10.1007/Bf00227884  1
1996 Wollert KC, Taga T, Saito M, Narazaki M, Kishimoto T, Glembotski CC, Vernallis AB, Heath JK, Pennica D, Wood WI, Chien KR. Cardiotrophin-1 activates a distinct form of cardiac muscle cell hypertrophy. Assembly of sarcomeric units in series VIA gp130/leukemia inhibitory factor receptor-dependent pathways. The Journal of Biological Chemistry. 271: 9535-45. PMID 8621626 DOI: 10.1074/Jbc.271.16.9535  1
1996 Davies MP, An RH, Doevendans P, Kubalak S, Chien KR, Kass RS. Developmental changes in ionic channel activity in the embryonic murine heart. Circulation Research. 78: 15-25. PMID 8603498 DOI: 10.1161/01.Res.78.1.15  1
1996 An RH, Davies MP, Doevendans PA, Kubalak SW, Bangalore R, Chien KR, Kass RS. Developmental changes in beta-adrenergic modulation of L-type Ca2+ channels in embryonic mouse heart. Circulation Research. 78: 371-8. PMID 8593695 DOI: 10.1161/01.Res.78.3.371  1
1996 Kubalak SW, Hunter JJ, Chien KR, Doevendans PA, Rockman HA, Tanaka N, Ross J. [26]Molecular analysis of cardiac muscle diseases based on mouse genetics Methods in Molecular Genetics. 8: 470-487. DOI: 10.1016/S1067-2389(96)80059-8  1
1995 Pennica D, King KL, Shaw KJ, Luis E, Rullamas J, Luoh SM, Darbonne WC, Knutzon DS, Yen R, Chien KR, Baker JB, Wood WI. Expression cloning of cardiotrophin 1, a cytokine that induces cardiac myocyte hypertrophy Proceedings of the National Academy of Sciences of the United States of America. 92: 1142-1146. PMID 7862649 DOI: 10.1073/Pnas.92.4.1142  1
1995 Knowlton KU, Rockman HA, Itani M, Vovan A, Seidman CE, Chien KR. Divergent pathways mediate the induction of ANF transgenes in neonatal and hypertrophic ventricular myocardium Journal of Clinical Investigation. 96: 1311-1318. PMID 7657806 DOI: 10.1172/Jci118166  1
1995 Zhou MD, Sucov HM, Evans RM, Chien KR. Retinoid-dependent pathways suppress myocardial cell hypertrophy Proceedings of the National Academy of Sciences of the United States of America. 92: 7391-7395. PMID 7638203 DOI: 10.1073/Pnas.92.16.7391  1
1995 Dyson E, Sucov HM, Kubalak SW, Schmid-Schonbein GW, DeLano FA, Evans RM, Ross J, Chien KR. Atrial-like phenotype is associated with embryonic ventricular failure in retinoid X receptor α -/- mice Proceedings of the National Academy of Sciences of the United States of America. 92: 7386-7390. PMID 7638202 DOI: 10.1073/Pnas.92.16.7386  1
1995 Grace AA, Chien KR. Congenital long QT syndromes. Toward molecular dissection of arrhythmia substrates. Circulation. 92: 2786-9. PMID 7586240 DOI: 10.1161/01.Cir.92.10.2786  0.01
1995 Lin MC, Rockman HA, Chien KR. Heart and lung disease in engineered mice Nature Medicine. 1: 749-751. PMID 7585174 DOI: 10.1038/Nm0895-749  1
1995 Hunter JJ, Tanaka N, Rockman HA, Ross J, Chien KR. Ventricular expression of a mlc-2v-ras fusion gene induces cardiac hypertrophy selective diastolic dysfunction in transgenic mice Journal of Biological Chemistry. 270: 23173-23178. PMID 7559464 DOI: 10.1074/Jbc.270.39.23173  1
1994 Lee KJ, Hickey R, Zhu H, Chien KR. Positive regulatory elements (HF-1a and HF-1b) and a novel negative regulatory element (HF-3) mediate ventricular muscle-specific expression of myosin light-chain 2-luciferase fusion genes in transgenic mice Molecular and Cellular Biology. 14: 1220-1229. PMID 8289802 DOI: 10.1128/Mcb.14.2.1220  1
1994 Evans SM, Tai LJ, Tan VP, Newton CB, Chien KR. Heterokaryons of cardiac myocytes and fibroblasts reveal the lack of dominance of the cardiac muscle phenotype. Molecular and Cellular Biology. 14: 4269-79. PMID 8196663 DOI: 10.1128/Mcb.14.6.4269  0.01
1994 Milano CA, Allen LF, Rockman HA, Dolber PC, McMinn TR, Chien KR, Johnson TD, Bond RA, Lefkowitz RJ. Enhanced myocardial function in transgenic mice overexpressing the β2-adrenergic receptor Science. 264: 582-586. PMID 8160017 DOI: 10.1126/Science.8160017  1
1994 Rockman HA, Ono S, Ross RS, Jones LR, Karimi M, Bhargava V, Ross J, Chien KR. Molecular and physiological alterations in murine ventricular dysfunction Proceedings of the National Academy of Sciences of the United States of America. 91: 2694-2698. PMID 8146176 DOI: 10.1073/Pnas.91.7.2694  1
1994 Navankasattusas S, Sawadogo M, Van Bilsen M, Dang CV, Chien KR. The basic helix-loop-helix protein upstream stimulating factor regulates the cardiac ventricular myosin light-chain 2 gene via independent cis regulatory elements Molecular and Cellular Biology. 14: 7331-7339. PMID 7935447 DOI: 10.1128/Mcb.14.11.7331  1
1994 Sucov HM, Dyson E, Gumeringer CL, Price J, Chien KR, Evans RM. RXRα mutant mice establish a genetic basis for vitamin A signaling in heart morphogenesis Genes and Development. 8: 1007-1018. PMID 7926783 DOI: 10.1101/Gad.8.9.1007  1
1993 O'Brien TX, Lee KJ, Chien KR. Positional specification of ventricular myosin light chain 2 expression in the primitive murine heart tube Proceedings of the National Academy of Sciences of the United States of America. 90: 5157-5161. PMID 8506363 DOI: 10.1073/Pnas.90.11.5157  1
1993 Hunter JJ, Zhu H, Lee KJ, Kubalak S, Chien KR. Targeting gene expression to specific cardiovascular cell types in transgenic mice Hypertension. 22: 608-617. PMID 8406667 DOI: 10.1161/01.Hyp.22.4.608  1
1993 Feldman ST, Gjerset R, Gately D, Chien KR, Feramisco JR. Expression of SV40 virus large T antigen by recombinant adenoviruses activates proliferation of corneal endothelium in vitro. The Journal of Clinical Investigation. 91: 1713-20. PMID 8386193 DOI: 10.1172/Jci116381  1
1993 Zhu H, Van Nguyen TB, Brown AB, Pourhosseini A, Garcia AV, Van Bilsen M, Chien KR. A novel, tissue-restricted zinc finger protein (HF-1b) binds to the cardiac regulatory element (HF-1b/MEF-2) in the rat myosin light-chain 2 gene Molecular and Cellular Biology. 13: 4432-4444. PMID 8321243 DOI: 10.1128/Mcb.13.7.4432  1
1992 Shubeita HE, Martinson EA, Van Bilsen M, Chien KR, Brown JH. Transcriptional activation of the cardiac myosin light chain 2 and atrial natriuretic factor genes by protein kinase C in neonatal rat ventricular myocytes Proceedings of the National Academy of Sciences of the United States of America. 89: 1305-1309. PMID 1531537 DOI: 10.1073/Pnas.89.4.1305  1
1992 Franz W, Drem G, Rudolph W, Chien KR, Hofschneidor PH, Kandolf R. Characterization of a cardiac-selective and developmentally upregulated promoter in tranagenic mice Journal of Molecular and Cellular Cardiology. 24. DOI: 10.1016/0022-2828(92)91695-2  0.01
1992 Zhu H, Navankasattusas S, Garcia AV, Evans SM, Chien KR. Synergistic interaction between a ubiquitous and a distinct muscle factor form an e box independent pathway for cardiac muscle gene expression Journal of Molecular and Cellular Cardiology. 24: 99. DOI: 10.1016/0022-2828(92)90324-S  1
1991 Rockman HA, Ross RS, Harris AN, Knowlton KU, Steinhelper ME, Field LJ, Ross J, Chien KR. Segregation of atrial-specific and inducible expression of an atrial natriuretic factor transgene in an in vivo murine model of cardiac hypertrophy. Proceedings of the National Academy of Sciences of the United States of America. 88: 8277-81. PMID 1832775 DOI: 10.1073/Pnas.88.18.8277  1
1989 Sills MN, Xu YC, Baracchini E, Goodman RH, Cooperman SS, Mandel G, Chien KR. Expression of diverse Na+ channel messenger RNAs in rat myocardium. Evidence for a cardiac-specific Na+ channel. The Journal of Clinical Investigation. 84: 331-6. PMID 2544627 DOI: 10.1172/Jci114158  1
1987 Chien KR, Meidell R, Gerard R. Tissue plasminogen activator: From molecular biology to myocardial infarction American Journal of the Medical Sciences. 293: 201-207. PMID 3105313 DOI: 10.1097/00000441-198703000-00009  1
1985 Buja LM, Muntz KH, Rosenbaum T, Haghani Z, Buja DK, Sen A, Chien KR, Willerson JT. Characterization of a potentially reversible increase in beta-adrenergic receptors in isolated, neonatal rat cardiac myocytes with impaired energy metabolism. Circulation Research. 57: 640-5. PMID 2994904 DOI: 10.1161/01.Res.57.4.640  0.01
1974 Foreman PB, Chien KR, Kukolich SG. Measurements of rotational relaxation cross sections for H2CO Chemical Physics Letters. 29: 295-297. DOI: 10.1016/0009-2614(74)85035-9  1
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