Kenneth R. Chien - Publications

University of California, San Diego, La Jolla, CA 
Molecular Biology

50 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Soh BS, Ng SY, Wu H, Buac K, Park JH, Lian X, Xu J, Foo KS, Felldin U, He X, Nichane M, Yang H, Bu L, Li RA, Lim B, ... Chien KR, et al. Endothelin-1 supports clonal derivation and expansion of cardiovascular progenitors derived from human embryonic stem cells. Nature Communications. 7: 10774. PMID 26952167 DOI: 10.1038/ncomms10774  0.36
2014 Drawnel FM, Boccardo S, Prummer M, Delobel F, Graff A, Weber M, Gérard R, Badi L, Kam-Thong T, Bu L, Jiang X, Hoflack JC, Kiialainen A, Jeworutzki E, Aoyama N, ... ... Chien KR, et al. Disease modeling and phenotypic drug screening for diabetic cardiomyopathy using human induced pluripotent stem cells. Cell Reports. 9: 810-21. PMID 25437537 DOI: 10.1016/j.celrep.2014.09.055  0.36
2014 Soh BS, Buac K, Xu H, Li E, Ng SY, Wu H, Chmielowiec J, Jiang X, Bu L, Li RA, Cowan C, Chien KR. N-cadherin prevents the premature differentiation of anterior heart field progenitors in the pharyngeal mesodermal microenvironment. Cell Research. 24: 1420-32. PMID 25367124 DOI: 10.1038/cr.2014.142  0.36
2014 Lian X, Xu J, Li J, Chien KR. Next-generation models of human cardiogenesis via genome editing. Cold Spring Harbor Perspectives in Medicine. 4: a013920. PMID 25237142 DOI: 10.1101/cshperspect.a013920  0.36
2014 Bang ML, Gu Y, Dalton ND, Peterson KL, Chien KR, Chen J. The muscle ankyrin repeat proteins CARP, Ankrd2, and DARP are not essential for normal cardiac development and function at basal conditions and in response to pressure overload. Plos One. 9: e93638. PMID 24736439 DOI: 10.1371/journal.pone.0093638  0.36
2013 Feinberg AW, Ripplinger CM, van der Meer P, Sheehy SP, Domian I, Chien KR, Parker KK. Functional differences in engineered myocardium from embryonic stem cell-derived versus neonatal cardiomyocytes. Stem Cell Reports. 1: 387-96. PMID 24286027 DOI: 10.1016/j.stemcr.2013.10.004  0.36
2013 Lui KO, Zangi L, Silva EA, Bu L, Sahara M, Li RA, Mooney DJ, Chien KR. Driving vascular endothelial cell fate of human multipotent Isl1+ heart progenitors with VEGF modified mRNA. Cell Research. 23: 1172-86. PMID 24018375 DOI: 10.1038/cr.2013.112  0.36
2013 Zangi L, Lui KO, von Gise A, Ma Q, Ebina W, Ptaszek LM, Später D, Xu H, Tabebordbar M, Gorbatov R, Sena B, Nahrendorf M, Briscoe DM, Li RA, Wagers AJ, ... ... Chien KR, et al. Modified mRNA directs the fate of heart progenitor cells and induces vascular regeneration after myocardial infarction. Nature Biotechnology. 31: 898-907. PMID 24013197 DOI: 10.1038/nbt.2682  0.36
2013 Yi BA, Mummery CL, Chien KR. Direct cardiomyocyte reprogramming: a new direction for cardiovascular regenerative medicine. Cold Spring Harbor Perspectives in Medicine. 3: a014050. PMID 24003244 DOI: 10.1101/cshperspect.a014050  0.36
2013 Lian X, Chien KR. The years of the monkey. Cell Research. 23: 1161-2. PMID 23958583 DOI: 10.1038/cr.2013.111  0.36
2012 Xu H, Yi BA, Chien KR. In vivo reprogramming for heart disease. Cell Research. 22: 1521-3. PMID 22751090 DOI: 10.1038/cr.2012.101  0.36
2012 Chien KR, Yi BA, Xu H, Mummery CL. Cardiomyocyte reprogramming and the new age of cellular alchemy. Journal of Molecular and Cellular Cardiology. 53: 311-3. PMID 22749824 DOI: 10.1016/j.yjmcc.2012.06.010  0.36
2012 Ptaszek LM, Mansour M, Ruskin JN, Chien KR. Towards regenerative therapy for cardiac disease. Lancet (London, England). 379: 933-42. PMID 22405796 DOI: 10.1016/S0140-6736(12)60075-0  0.36
2012 Xu H, Yi BA, Wu H, Bock C, Gu H, Lui KO, Park JH, Shao Y, Riley AK, Domian IJ, Hu E, Willette R, Lepore J, Meissner A, Wang Z, ... Chien KR, et al. Highly efficient derivation of ventricular cardiomyocytes from induced pluripotent stem cells with a distinct epigenetic signature. Cell Research. 22: 142-54. PMID 22064699 DOI: 10.1038/cr.2011.171  0.36
2011 Knöll R, Linke WA, Zou P, Miocic S, Kostin S, Buyandelger B, Ku CH, Neef S, Bug M, Schäfer K, Knöll G, Felkin LE, Wessels J, Toischer K, Hagn F, ... ... Chien KR, et al. Telethonin deficiency is associated with maladaptation to biomechanical stress in the mammalian heart. Circulation Research. 109: 758-69. PMID 21799151 DOI: 10.1161/CIRCRESAHA.111.245787  0.36
2011 Vunjak-Novakovic G, Lui KO, Tandon N, Chien KR. Bioengineering heart muscle: a paradigm for regenerative medicine. Annual Review of Biomedical Engineering. 13: 245-67. PMID 21568715 DOI: 10.1146/annurev-bioeng-071910-124701  0.36
2011 Xu H, Yi BA, Chien KR. Shortcuts to making cardiomyocytes. Nature Cell Biology. 13: 191-3. PMID 21364566 DOI: 10.1038/ncb0311-191  0.36
2011 Terada R, Warren S, Lu JT, Chien KR, Wessels A, Kasahara H. Ablation of Nkx2-5 at mid-embryonic stage results in premature lethality and cardiac malformation. Cardiovascular Research. 91: 289-99. PMID 21285290 DOI: 10.1093/cvr/cvr037  0.36
2010 Bu L, Gao X, Jiang X, Chien KR, Wang Z. Targeted conditional gene knockout in human embryonic stem cells Cell Research. 20: 379-382. PMID 20142843 DOI: 10.1038/cr.2010.23  0.36
2010 Yi BA, Wernet O, Chien KR. Pregenerative medicine: developmental paradigms in the biology of cardiovascular regeneration. The Journal of Clinical Investigation. 120: 20-8. PMID 20051633 DOI: 10.1172/JCI40820  0.36
2009 Domian IJ, Chiravuri M, van der Meer P, Feinberg AW, Shi X, Shao Y, Wu SM, Parker KK, Chien KR. Generation of functional ventricular heart muscle from mouse ventricular progenitor cells. Science (New York, N.Y.). 326: 426-9. PMID 19833966 DOI: 10.1126/science.1177350  0.36
2009 Hansson EM, Lindsay ME, Chien KR. Regeneration next: toward heart stem cell therapeutics. Cell Stem Cell. 5: 364-77. PMID 19796617 DOI: 10.1016/j.stem.2009.09.004  0.36
2009 Bu L, Jiang X, Martin-Puig S, Caron L, Zhu S, Shao Y, Roberts DJ, Huang PL, Domian IJ, Chien KR. Human ISL1 heart progenitors generate diverse multipotent cardiovascular cell lineages. Nature. 460: 113-7. PMID 19571884 DOI: 10.1038/nature08191  0.36
2009 Takeda M, Briggs LE, Wakimoto H, Marks MH, Warren SA, Lu JT, Weinberg EO, Robertson KD, Chien KR, Kasahara H. Slow progressive conduction and contraction defects in loss of Nkx2-5 mice after cardiomyocyte terminal differentiation. Laboratory Investigation; a Journal of Technical Methods and Pathology. 89: 983-93. PMID 19546853 DOI: 10.1038/labinvest.2009.59  0.36
2008 Chien KR, Domian IJ, Parker KK. Cardiogenesis and the complex biology of regenerative cardiovascular medicine. Science (New York, N.Y.). 322: 1494-7. PMID 19056974 DOI: 10.1126/science.1163267  0.36
2008 Briggs LE, Takeda M, Cuadra AE, Wakimoto H, Marks MH, Walker AJ, Seki T, Oh SP, Lu JT, Sumners C, Raizada MK, Horikoshi N, Weinberg EO, Yasui K, Ikeda Y, ... Chien KR, et al. Perinatal loss of Nkx2-5 results in rapid conduction and contraction defects. Circulation Research. 103: 580-90. PMID 18689573 DOI: 10.1161/CIRCRESAHA.108.171835  0.36
2008 Zhou B, Ma Q, Rajagopal S, Wu SM, Domian I, Rivera-Feliciano J, Jiang D, von Gise A, Ikeda S, Chien KR, Pu WT. Epicardial progenitors contribute to the cardiomyocyte lineage in the developing heart. Nature. 454: 109-13. PMID 18568026 DOI: 10.1038/nature07060  0.36
2008 Geier C, Gehmlich K, Ehler E, Hassfeld S, Perrot A, Hayess K, Cardim N, Wenzel K, Erdmann B, Krackhardt F, Posch MG, Osterziel KJ, Bublak A, Nägele H, Scheffold T, ... ... Chien KR, et al. Beyond the sarcomere: CSRP3 mutations cause hypertrophic cardiomyopathy. Human Molecular Genetics. 17: 2753-65. PMID 18505755 DOI: 10.1093/hmg/ddn160  0.36
2008 Martin-Puig S, Wang Z, Chien KR. Lives of a Heart Cell: Tracing the Origins of Cardiac Progenitors Cell Stem Cell. 2: 320-331. PMID 18397752 DOI: 10.1016/j.stem.2008.03.010  0.36
2008 Osafune K, Caron L, Borowiak M, Martinez RJ, Fitz-Gerald CS, Sato Y, Cowan CA, Chien KR, Melton DA. Marked differences in differentiation propensity among human embryonic stem cell lines. Nature Biotechnology. 26: 313-5. PMID 18278034 DOI: 10.1038/nbt1383  0.36
2008 Chan JY, Takeda M, Briggs LE, Graham ML, Lu JT, Horikoshi N, Weinberg EO, Aoki H, Sato N, Chien KR, Kasahara H. Identification of cardiac-specific myosin light chain kinase. Circulation Research. 102: 571-80. PMID 18202317 DOI: 10.1161/CIRCRESAHA.107.161687  0.36
2008 Laugwitz KL, Moretti A, Caron L, Nakano A, Chien KR. Islet1 cardiovascular progenitors: a single source for heart lineages? Development (Cambridge, England). 135: 193-205. PMID 18156162 DOI: 10.1242/dev.001883  0.36
2007 Qyang Y, Martin-Puig S, Chiravuri M, Chen S, Xu H, Bu L, Jiang X, Lin L, Granger A, Moretti A, Caron L, Wu X, Clarke J, Taketo MM, Laugwitz KL, ... ... Chien KR, et al. The renewal and differentiation of Isl1+ cardiovascular progenitors are controlled by a Wnt/beta-catenin pathway. Cell Stem Cell. 1: 165-79. PMID 18371348 DOI: 10.1016/j.stem.2007.05.018  0.36
2007 Kaye DM, Preovolos A, Marshall T, Byrne M, Hoshijima M, Hajjar R, Mariani JA, Pepe S, Chien KR, Power JM. Percutaneous cardiac recirculation-mediated gene transfer of an inhibitory phospholamban peptide reverses advanced heart failure in large animals. Journal of the American College of Cardiology. 50: 253-60. PMID 17631218 DOI: 10.1016/j.jacc.2007.03.047  0.36
2007 Smart N, Risebro CA, Melville AA, Moses K, Schwartz RJ, Chien KR, Riley PR. Thymosin beta-4 is essential for coronary vessel development and promotes neovascularization via adult epicardium. Annals of the New York Academy of Sciences. 1112: 171-88. PMID 17495252 DOI: 10.1196/annals.1415.000  0.36
2007 Hirai M, Ohbayashi T, Horiguchi M, Okawa K, Hagiwara A, Chien KR, Kita T, Nakamura T. Fibulin-5/DANCE has an elastogenic organizer activity that is abrogated by proteolytic cleavage in vivo. The Journal of Cell Biology. 176: 1061-71. PMID 17371835 DOI: 10.1083/jcb.200611026  0.36
2007 Prall OW, Menon MK, Solloway MJ, Watanabe Y, Zaffran S, Bajolle F, Biben C, McBride JJ, Robertson BR, Chaulet H, Stennard FA, Wise N, Schaft D, Wolstein O, Furtado MB, ... ... Chien KR, et al. An Nkx2-5/Bmp2/Smad1 negative feedback loop controls heart progenitor specification and proliferation. Cell. 128: 947-59. PMID 17350578 DOI: 10.1016/j.cell.2007.01.042  0.36
2007 Pomiès P, Pashmforoush M, Vegezzi C, Chien KR, Auffray C, Beckerle MC. The cytoskeleton-associated PDZ-LIM protein, ALP, acts on serum response factor activity to regulate muscle differentiation. Molecular Biology of the Cell. 18: 1723-33. PMID 17332502 DOI: 10.1091/mbc.E06-09-0815  0.36
2007 Smart N, Risebro CA, Melville AA, Moses K, Schwartz RJ, Chien KR, Riley PR. Thymosin beta4 induces adult epicardial progenitor mobilization and neovascularization. Nature. 445: 177-82. PMID 17108969 DOI: 10.1038/nature05383  0.36
2006 Moretti A, Caron L, Nakano A, Lam JT, Bernshausen A, Chen Y, Qyang Y, Bu L, Sasaki M, Martin-Puig S, Sun Y, Evans SM, Laugwitz KL, Chien KR. Multipotent embryonic isl1+ progenitor cells lead to cardiac, smooth muscle, and endothelial cell diversification. Cell. 127: 1151-65. PMID 17123592 DOI: 10.1016/j.cell.2006.10.029  0.36
2006 Weissgerber P, Held B, Bloch W, Kaestner L, Chien KR, Fleischmann BK, Lipp P, Flockerzi V, Freichel M. Reduced cardiac L-type Ca2+ current in Ca(V)beta2-/- embryos impairs cardiac development and contraction with secondary defects in vascular maturation. Circulation Research. 99: 749-57. PMID 16946137 DOI: 10.1161/01.RES.0000243978.15182.c1  0.36
2005 Merki E, Zamora M, Raya A, Kawakami Y, Wang J, Zhang X, Burch J, Kubalak SW, Kaliman P, Izpisua Belmonte JC, Chien KR, Ruiz-Lozano P. Epicardial retinoid X receptor alpha is required for myocardial growth and coronary artery formation. Proceedings of the National Academy of Sciences of the United States of America. 102: 18455-60. PMID 16352730 DOI: 10.1073/pnas.0504343102  0.36
2005 Lorenzen-Schmidt I, Stuyvers BD, ter Keurs HE, Date MO, Hoshijima M, Chien KR, McCulloch AD, Omens JH. Young MLP deficient mice show diastolic dysfunction before the onset of dilated cardiomyopathy. Journal of Molecular and Cellular Cardiology. 39: 241-50. PMID 15978612 DOI: 10.1016/j.yjmcc.2005.05.006  0.36
2005 Laugwitz KL, Moretti A, Lam J, Gruber P, Chen Y, Woodard S, Lin LZ, Cai CL, Lu MM, Reth M, Platoshyn O, Yuan JX, Evans S, Chien KR. Postnatal isl1+ cardioblasts enter fully differentiated cardiomyocyte lineages. Nature. 433: 647-53. PMID 15703750 DOI: 10.1038/nature03215  0.36
2004 Hayashi T, Arimura T, Itoh-Satoh M, Ueda K, Hohda S, Inagaki N, Takahashi M, Hori H, Yasunami M, Nishi H, Koga Y, Nakamura H, Matsuzaki M, Choi BY, Bae SW, ... ... Chien KR, et al. Tcap gene mutations in hypertrophic cardiomyopathy and dilated cardiomyopathy. Journal of the American College of Cardiology. 44: 2192-201. PMID 15582318 DOI: 10.1016/j.jacc.2004.08.058  0.36
2004 Minamisawa S, Oshikawa J, Takeshima H, Hoshijima M, Wang Y, Chien KR, Ishikawa Y, Matsuoka R. Junctophilin type 2 is associated with caveolin-3 and is down-regulated in the hypertrophic and dilated cardiomyopathies Biochemical and Biophysical Research Communications. 325: 852-856. PMID 15541368 DOI: 10.1016/j.bbrc.2004.10.107  0.36
2004 Pashmforoush M, Lu JT, Chen H, Amand TS, Kondo R, Pradervand S, Evans SM, Clark B, Feramisco JR, Giles W, Ho SY, Benson DW, Silberbach M, Shou W, Chien KR. Nkx2-5 pathways and congenital heart disease; loss of ventricular myocyte lineage specification leads to progressive cardiomyopathy and complete heart block. Cell. 117: 373-86. PMID 15109497 DOI: 10.1016/S0092-8674(04)00405-2  0.36
2004 Chen H, Shi S, Acosta L, Li W, Lu J, Bao S, Chen Z, Yang Z, Schneider MD, Chien KR, Conway SJ, Yoder MC, Haneline LS, Franco D, Shou W. BMP10 is essential for maintaining cardiac growth during murine cardiogenesis. Development (Cambridge, England). 131: 2219-31. PMID 15073151 DOI: 10.1242/dev.01094  0.36
2004 Bale TL, Hoshijima M, Gu Y, Dalton N, Anderson KR, Lee KF, Rivier J, Chien KR, Vale WW, Peterson KL. The cardiovascular physiologic actions of urocortin II: acute effects in murine heart failure. Proceedings of the National Academy of Sciences of the United States of America. 101: 3697-702. PMID 14990799 DOI: 10.1073/pnas.0307324101  0.36
2002 Jiang X, Choudhary B, Merki E, Chien KR, Maxson RE, Sucov HM. Normal fate and altered function of the cardiac neural crest cell lineage in retinoic acid receptor mutant embryos. Mechanisms of Development. 117: 115-22. PMID 12204252 DOI: 10.1016/S0925-4773(02)00206-X  0.36
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