Curtis D. Klaassen - Publications

Affiliations: 
University of Kansas, Lawrence, KS, United States 
Area:
Toxicology, Pharmacology, Molecular Biology

375 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Liu J, Lickteig AJ, Zhang Y, Csanaky IL, Klaassen CD. Activation of Nrf2 decreases bile acid concentrations in livers of female mice. Xenobiotica; the Fate of Foreign Compounds in Biological Systems. 1-11. PMID 33522359 DOI: 10.1080/00498254.2021.1880033  1
2020 Liu J, Lu YF, Corton JC, Klaassen CD. Expression of cytochrome P450 isozyme transcripts and activities in human livers. Xenobiotica; the Fate of Foreign Compounds in Biological Systems. 1-24. PMID 33350342 DOI: 10.1080/00498254.2020.1867929  0.88
2020 Liu J, Cui JY, Lu YF, Corton JC, Klaassen CD. Sex-, age-, and race/ethnicity-dependent variations in drug-processing and NRF2-regulated genes in human livers. Drug Metabolism and Disposition: the Biological Fate of Chemicals. PMID 33162398 DOI: 10.1124/dmd.120.000181  1
2020 Ma C, Guo Y, Klaassen CD. . Drug Metabolism and Disposition: the Biological Fate of Chemicals. PMID 33093018 DOI: 10.1124/dmd.120.000166  0.84
2020 Wu KC, Reisman SA, Klaassen CD. Tissue distribution, hormonal regulation, ontogeny, diurnal expression, and induction of mouse cystine transporters Slc3a1 and Slc7a9. Free Radical Research. 1-10. PMID 32873097 DOI: 10.1080/10715762.2020.1812597  0.88
2020 Zhang Y, Lickteig AJ, Liu J, Csanaky IL, Klaassen CD. Effects of ablation and activation of Nrf2 on bile acid homeostasis in mice. Toxicology and Applied Pharmacology. 115170. PMID 32738332 DOI: 10.1016/J.Taap.2020.115170  1
2020 Csanaky IL, Lickteig AJ, Zhang Y, Klaassen CD. Effects of the patent ductus venosus on bile acid homeostasis in aryl hydrocarbon receptor (AhR)-null mice. Toxicology and Applied Pharmacology. 115136. PMID 32679164 DOI: 10.1016/J.Taap.2020.115136  1
2020 Choudhuri S, Klaassen CD. Elucidation of OATP1B1 and 1B3 transporter function using transgenic rodent models and commonly known single nucleotide polymorphisms. Toxicology and Applied Pharmacology. 399: 115039. PMID 32407928 DOI: 10.1016/J.Taap.2020.115039  0.56
2020 Liu J, Gunewardena S, Yue Cui J, Klaassen CD, Chorley BN, Corton JC. Transplacental arsenic exposure produced 5-methylcytosine methylation changes and aberrant microRNA expressions in livers of male fetal mice. Toxicology. 152409. PMID 32068019 DOI: 10.1016/J.Tox.2020.152409  0.88
2019 Tang C, Fu Q, Chen X, Hu Y, Renaud H, Ma C, Rao T, Chen Y, Tan Z, Klaassen CD, Shi S, Guo Y. The biotransformation of by human gut microbiota. Xenobiotica; the Fate of Foreign Compounds in Biological Systems. 1-30. PMID 31858877 DOI: 10.1080/00498254.2019.1707908  0.84
2019 Wang P, Sachar M, Lu J, Shehu AI, Zhu J, Chen J, Liu K, Anderson KE, Xie W, Gonzalez FJ, Klaassen CD, Ma X. The essential role of the transporter ABCG2 in the pathophysiology of erythropoietic protoporphyria. Science Advances. 5: eaaw6127. PMID 31555729 DOI: 10.1126/Sciadv.Aaw6127  0.8
2019 Li G, Han L, Ma R, Saeed K, Xiong H, Klaassen C, Lu Y, Zhang Y. Glucocorticoids increase renal excretion of urate in mice by down-regulating urate transporter 1. Drug Metabolism and Disposition: the Biological Fate of Chemicals. PMID 31519697 DOI: 10.1124/dmd.119.087700  1
2019 Scialis RJ, Aleksunes LM, Csanaky IL, Klaassen CD, Manautou JE. Identification and Characterization of Efflux Transporters that Modulate the Subtoxic Disposition of Diclofenac and its Metabolites. Drug Metabolism and Disposition: the Biological Fate of Chemicals. PMID 31399506 DOI: 10.1124/dmd.119.086603  0.96
2019 Lickteig AJ, Zhang Y, Klaassen CD, Csanaky IL. Effects of Absence of Constitutive Androstane Receptor (CAR) on Bile Acid Homeostasis in Male and Female Mice. Toxicological Sciences : An Official Journal of the Society of Toxicology. PMID 31225615 DOI: 10.1093/Toxsci/Kfz143  1
2019 Wen X, Baker AA, Klaassen CD, Corton JC, Richardson JR, Aleksunes LM. Hepatic Carboxylesterases are Differentially Regulated in PPARα-Null Mice Treated with Perfluorooctanoic Acid. Toxicology. PMID 30685356 DOI: 10.1016/J.Tox.2019.01.014  0.68
2019 Wu KC, Cui JY, Liu J, Lu H, Zhong XB, Klaassen CD. RNA-Seq provides new insights on the relative mRNA abundance of antioxidant components during mouse liver development. Free Radical Biology & Medicine. PMID 30659941 DOI: 10.1016/J.Freeradbiomed.2019.01.017  1
2018 Rooney J, Oshida K, Vasani N, Vallanat B, Ryan N, Chorley BN, Wang X, Bell DA, Wu KC, Aleksunes LM, Klaassen CD, Kensler TW, Corton JC. Activation of Nrf2 in the liver is associated with stress resistance mediated by suppression of the growth hormone-regulated STAT5b transcription factor. Plos One. 13: e0200004. PMID 30114225 DOI: 10.1371/Journal.Pone.0200004  0.88
2018 Liu J, Lu YF, Wu Q, Xu SF, Shi FG, Klaassen CD. Oleanolic acid reprograms the liver to protect against hepatotoxicants, but is hepatotoxic at high doses. Liver International : Official Journal of the International Association For the Study of the Liver. PMID 30079536 DOI: 10.1111/Liv.13940  0.88
2018 Csanaky IL, Lickteig AJ, Klaassen CD. Aryl hydrocarbon receptor (AhR) mediated short-term effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on bile acid homeostasis in wild-type and AhR-null mice. Toxicology and Applied Pharmacology. PMID 29452137 DOI: 10.1016/J.Taap.2018.02.005  0.96
2018 Zhang Y, Lickteig AJ, Csanaky IL, Klaassen CD. Activation of PPARα decreases bile acids in livers of female mice while maintaining bile flow and biliary bile acid excretion. Toxicology and Applied Pharmacology. 338: 112-123. PMID 29175453 DOI: 10.1016/J.Taap.2017.11.014  1
2017 Zhang Y, Zhang Y, Klaassen CD, Cheng X. Alteration of bile acid and cholesterol biosynthesis and transport by perfluorononanoic acid (PFNA) in mice. Toxicological Sciences : An Official Journal of the Society of Toxicology. PMID 29112762 DOI: 10.1093/Toxsci/Kfx237  1
2017 Wang X, Han L, Li G, Peng W, Gao X, Klaassen CD, Fan G, Zhang Y. Identification of natural products as inhibitors of human organic anion transporters (OAT1 and OAT3) and their protective effect on mercury-induced toxicity. Toxicological Sciences : An Official Journal of the Society of Toxicology. PMID 29045746 DOI: 10.1093/Toxsci/Kfx216  1
2017 Choudhuri S, Patton GW, Chanderbhan RF, Mattia A, Klaassen CD. From Classical Toxicology To TOX21 Some Critical Conceptual and Technological Advances in the Molecular Understanding of the Toxic Response Beginning from the Last Quarter of the 20Th Century. Toxicological Sciences : An Official Journal of the Society of Toxicology. PMID 28973688 DOI: 10.1093/Toxsci/Kfx186  0.56
2017 Zhang Y, Lickteig AJ, Csanaky IL, Klaassen CD. Clofibrate decreases bile acids in livers of male mice by increasing biliary bile acid excretion in a PPARα-dependent manner. Toxicological Sciences : An Official Journal of the Society of Toxicology. PMID 28973556 DOI: 10.1093/Toxsci/Kfx191  1
2017 Fu ZD, Selwyn FP, Cui JY, Klaassen CD. RNA-Seq Profiling of Intestinal Expression of Xenobiotic Processing Genes in Germ-Free Mice. Drug Metabolism and Disposition: the Biological Fate of Chemicals. PMID 28939687 DOI: 10.1124/Dmd.117.077313  1
2017 Yu AM, Ingelman-Sundberg M, Cherrington NJ, Aleksunes LM, Zanger UM, Xie W, Jeong H, Morgan EM, Turnbaugh PJ, Klaassen CD, Bhatt AP, Redinbo MR, Hao P, Waxman DJ, Wang L, et al. Regulation of drug metabolism and toxicity by multiple factors of genetics, epigenetics, lncRNAs, gut microbiota, and diseases: a meeting report of the 21(st) International Symposium on Microsomes and Drug Oxidations (MDO). Acta Pharmaceutica Sinica. B. 7: 241-248. PMID 28388695 DOI: 10.1016/J.Apsb.2016.12.006  0.76
2017 Lu H, Lei X, Liu J, Klaassen C. Regulation of hepatic microRNA expression by hepatocyte nuclear factor 4 alpha. World Journal of Hepatology. 9: 191-208. PMID 28217257 DOI: 10.4254/wjh.v9.i4.191  0.88
2016 Rockwell CE, Turley AE, Cheng X, Fields PE, Klaassen CD. Persistent alterations in immune cell populations and function from a single dose of perfluorononanoic acid (PFNA) in C57Bl/6 mice. Food and Chemical Toxicology : An International Journal Published For the British Industrial Biological Research Association. PMID 27939831 DOI: 10.1016/J.Fct.2016.12.004  1
2016 Guo Y, Zhang Y, Huang W, Selwyn FP, Klaassen CD. Dose-response effect of berberine on bile acid profile and gut microbiota in mice. Bmc Complementary and Alternative Medicine. 16: 394. PMID 27756364 DOI: 10.1186/S12906-016-1367-7  1
2016 Guo Y, Cui JY, Lu H, Klaassen CD. Effect of nine diets on mRNAs of phase-II conjugation enzymes in livers of mice. Xenobiotica; the Fate of Foreign Compounds in Biological Systems. 1-10. PMID 27686132 DOI: 10.1080/00498254.2016.1213926  1
2016 Fiume MM, Heldreth B, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD, Liebler DC, Marks JG, Shank RC, Slaga TJ, Snyder PW, Andersen FA. Safety Assessment of Alkyl PEG/PPG Ethers as Used in Cosmetics. International Journal of Toxicology. 35: 60S-89S. PMID 27383199 DOI: 10.1177/1091581816650626  0.88
2016 Fiume MM, Heldreth B, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD, Liebler DC, Marks JG, Shank RC, Slaga TJ, Snyder PW, Andersen FA. Safety Assessment of Microbial Polysaccharide Gums as Used in Cosmetics. International Journal of Toxicology. 35: 5S-49S. PMID 27383198 DOI: 10.1177/1091581816651606  0.88
2016 Fiume MM, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD, Liebler DC, Marks JG, Shank RC, Slaga TJ, Snyder PW, Andersen FA. Safety Assessment of Nitrocellulose and Collodion as Used in Cosmetics. International Journal of Toxicology. 35: 50S-59S. PMID 27383197 DOI: 10.1177/1091581816651607  0.88
2016 Cui JY, Klaassen CD. RNA-Seq Reveals Common and Unique PXR- and CAR-target Gene Signatures in the Mouse Liver Transcriptome. Biochimica Et Biophysica Acta. PMID 27113289 DOI: 10.1016/J.Bbagrm.2016.04.010  1
2016 Fu ZD, Selwyn FP, Cui JY, Klaassen CD. RNA-Seq Quantification of Xenobiotic Processing Genes in Various Sections of the Intestine in Comparison to the Liver of Male Mice. Drug Metabolism and Disposition: the Biological Fate of Chemicals. PMID 27048750 DOI: 10.1124/Dmd.115.068270  0.88
2016 Lickteig AJ, Csanaky IL, Pratt-Hyatt M, Klaassen CD. Activation of Constitutive Androstane Receptor (CAR) in Mice Results in Maintained Biliary Excretion of Bile Acids Despite a Marked Decrease of Bile Acids in Liver. Toxicological Sciences : An Official Journal of the Society of Toxicology. 151: 403-18. PMID 26984780 DOI: 10.1093/Toxsci/Kfw054  0.96
2016 Renaud HJ, Klaassen CD, Csanaky IL. Calorie Restriction Increases P-Glycoprotein and Decreases Intestinal Absorption of Digoxin in Mice. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 44: 366-9. PMID 26744253 DOI: 10.1124/Dmd.115.064766  0.96
2015 Fiume M, Heldreth B, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD, Liebler DC, Marks JG, Shank RC, Slaga TJ, Snyder PW, Andersen FA. Safety Assessment of Alkyl Ethylhexanoates as Used in Cosmetics. International Journal of Toxicology. 34: 61S-73S. PMID 26684798 DOI: 10.1177/1091581815617794  0.88
2015 Becker LC, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD, Liebler DC, Marks JG, Shank RC, Slaga TJ, Snyder PW, Andersen FA. Safety Assessment of Panax spp Root-Derived Ingredients as Used in Cosmetics. International Journal of Toxicology. 34: 5S-42S. PMID 26684797 DOI: 10.1177/1091581815610508  0.88
2015 Fiume MM, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD, Liebler DC, Marks JG, Shank RC, Slaga TJ, Snyder PW, Andersen FA. Safety Assessment of Boron Nitride as Used in Cosmetics. International Journal of Toxicology. 34: 53S-60S. PMID 26684796 DOI: 10.1177/1091581815617793  0.88
2015 Becker LC, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD, Liebler DC, Marks JG, Shank RC, Slaga TJ, Snyder PW, Andersen FA. Safety Assessment of Synthetic Fluorphlogopite as Used in Cosmetics. International Journal of Toxicology. 34: 43S-52S. PMID 26684795 DOI: 10.1177/1091581815613513  0.88
2015 Selwyn FP, Cheng SL, Klaassen CD, Cui JY. Regulation of Hepatic Drug-metabolizing Enzymes in Germ-free mice by Conventionalization and Probiotics. Drug Metabolism and Disposition: the Biological Fate of Chemicals. PMID 26586378 DOI: 10.1124/Dmd.115.067504  0.92
2015 Li CY, Renaud HJ, Klaassen CD, Cui JY. Age-specific Regulation of Drug-processing Genes in Mouse Liver by Ligands of Xenobiotic-sensing Transcription Factors. Drug Metabolism and Disposition: the Biological Fate of Chemicals. PMID 26577535 DOI: 10.1124/Dmd.115.066639  1
2015 Gunewardena SS, Yoo B, Peng L, Lu H, Zhong X, Klaassen CD, Cui JY. Deciphering the Developmental Dynamics of the Mouse Liver Transcriptome. Plos One. 10: e0141220. PMID 26496202 DOI: 10.1371/Journal.Pone.0141220  0.88
2015 Fu ZD, Cui JY, Klaassen CD. The Role of Sirt1 in Bile Acid Regulation during Calorie Restriction in Mice. Plos One. 10: e0138307. PMID 26372644 DOI: 10.1371/Journal.Pone.0138307  1
2015 Becker LC, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD, Liebler DC, Marks JG, Shank RC, Slaga TJ, Snyder PW, Andersen FA. Safety Assessment of Pentaerythrityl Tetraesters as Used in Cosmetics. International Journal of Toxicology. 34: 99S-112S. PMID 26362123 DOI: 10.1177/1091581815596731  0.88
2015 Fiume MM, Heldreth BA, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD, Liebler DC, Marks JG, Shank RC, Slaga TJ, Snyder PW, Andersen FA. Safety Assessment of Ethanolamine and Ethanolamine Salts as Used in Cosmetics. International Journal of Toxicology. 34: 84S-98S. PMID 26362122 DOI: 10.1177/1091581815596439  0.88
2015 Johnson W, Heldreth B, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD, Liebler DC, Marks JG, Shank RC, Slaga TJ, Snyder PW, Andersen FA. Safety Assessment of Alkyl PEG Sulfosuccinates as Used in Cosmetics. International Journal of Toxicology. 34: 70S-83S. PMID 26362121 DOI: 10.1177/1091581815594755  0.88
2015 Fiume MM, Heldreth BA, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD, Liebler DC, Marks JG, Shank RC, Slaga TJ, Snyder PW, Andersen FA. Safety Assessment of Alkyl Esters as Used in Cosmetics. International Journal of Toxicology. 34: 5S-69S. PMID 26362120 DOI: 10.1177/1091581815594027  0.88
2015 Klaassen CD, Cui JY. Review: Mechanisms of How the Intestinal Microbiota Alters the Effects of Drugs and Bile Acids. Drug Metabolism and Disposition: the Biological Fate of Chemicals. PMID 26261286 DOI: 10.1124/Dmd.115.065698  1
2015 Fiume MM, Boyer I, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD, Liebler DC, Marks JG, Shank RC, Slaga TJ, Snyder PW, Andersen FA. Safety Assessment of Talc as Used in Cosmetics. International Journal of Toxicology. 34: 66S-129S. PMID 26227892 DOI: 10.1177/1091581815586797  0.88
2015 Johnson W, Heldreth B, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD, Liebler DC, Marks JG, Shank RC, Slaga TJ, Snyder PW, Andersen FA. Safety Assessment of Galactomannans as Used in Cosmetics. International Journal of Toxicology. 34: 35S-65S. PMID 26227890 DOI: 10.1177/1091581815586798  0.88
2015 Fiume MM, Heldreth BA, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD, Liebler DC, Marks JG, Shank RC, Slaga TJ, Snyder PW, Andersen FA. Safety Assessment of Ethanolamides as Used in Cosmetics. International Journal of Toxicology. 34: 18S-34S. PMID 26227889 DOI: 10.1177/1091581815586599  0.88
2015 Oshida K, Vasani N, Thomas RS, Applegate D, Gonzalez FJ, Aleksunes LM, Klaassen CD, Corton JC. Screening a mouse liver gene expression compendium identifies modulators of the aryl hydrocarbon receptor (AhR). Toxicology. 336: 99-112. PMID 26215100 DOI: 10.1016/J.Tox.2015.07.005  0.88
2015 Selwyn FP, Csanaky IL, Zhang Y, Klaassen CD. Importance of Large Intestine in Regulating Bile Acids and Glucagon-Like Peptide-1 in Germ-Free Mice. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 43: 1544-56. PMID 26199423 DOI: 10.1124/Dmd.115.065276  1
2015 Selwyn FP, Cheng SL, Bammler TK, Prasad B, Vrana M, Klaassen C, Cui JY. Developmental Regulation of Drug-processing Genes in Livers of Germ-free Mice. Toxicological Sciences : An Official Journal of the Society of Toxicology. PMID 26032512 DOI: 10.1093/Toxsci/Kfv110  0.88
2015 Selwyn FP, Cui JY, Klaassen CD. RNA-Seq Quantification of Hepatic Drug Processing Genes in Germ-Free mice. Drug Metabolism and Disposition: the Biological Fate of Chemicals. PMID 25956306 DOI: 10.1124/Dmd.115.063545  1
2015 Oshida K, Vasani N, Jones C, Moore T, Hester S, Nesnow S, Auerbach S, Geter DR, Aleksunes LM, Thomas RS, Applegate D, Klaassen CD, Corton JC. Identification of chemical modulators of the constitutive activated receptor (CAR) in a gene expression compendium. Nuclear Receptor Signaling. 13: e002. PMID 25949234 DOI: 10.1621/Nrs.13002  0.68
2015 Guo Y, Cui JY, Lu H, Klaassen CD. Effect of various diets on the expression of phase-I drug-metabolizing enzymes in livers of mice. Xenobiotica; the Fate of Foreign Compounds in Biological Systems. 45: 586-97. PMID 25733028 DOI: 10.3109/00498254.2015.1006300  1
2015 Oshida K, Vasani N, Thomas RS, Applegate D, Rosen M, Abbott B, Lau C, Guo G, Aleksunes LM, Klaassen C, Corton JC. Identification of modulators of the nuclear receptor peroxisome proliferator-activated receptor α (PPARα) in a mouse liver gene expression compendium. Plos One. 10: e0112655. PMID 25689681 DOI: 10.1371/Journal.Pone.0112655  0.88
2015 Song P, Rockwell CE, Cui JY, Klaassen CD. Individual bile acids have differential effects on bile acid signaling in mice. Toxicology and Applied Pharmacology. 283: 57-64. PMID 25582706 DOI: 10.1016/J.Taap.2014.12.005  0.88
2015 Guo Y, Cui JY, Lu H, Klaassen CD. Effect of nine diets on xenobiotic transporters in livers of mice. Xenobiotica; the Fate of Foreign Compounds in Biological Systems. 45: 634-41. PMID 25566878 DOI: 10.3109/00498254.2014.1001009  1
2015 Lu YF, Liu J, Wu KC, Klaassen CD. Protection against phalloidin-induced liver injury by oleanolic acid involves Nrf2 activation and suppression of Oatp1b2. Toxicology Letters. 232: 326-32. PMID 25280775 DOI: 10.1016/J.Toxlet.2014.09.027  0.88
2015 Oshida K, Vasani N, Thomas RS, Applegate D, Rosen M, Abbott B, Lau C, Guo G, Aleksunes LM, Klaassen C, Corton JC. Expression of Cyp4a10 and Pdk4 genes in the livers of mice exposed to reference compound activators of CAR, FXR, Nrf2, PPARα, and PXR. Plos One. DOI: 10.1371/Journal.Pone.0112655.G004  0.68
2015 Becker LC, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD, Liebler DC, Marks JG, Shank RC, Slaga TJ, Snyder PW, Andersen FA. Safety Assessment of Dialkyl Malates as Used in Cosmetics International Journal of Toxicology. 34: 5S-17S. DOI: 10.1177/1091581815584625  0.88
2014 Burnett C, Heldreth B, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD, Liebler DC, Marks JG, Shank RC, Slaga TJ, Snyder PW, Andersen FA. Safety assessment of nylon as used in cosmetics. International Journal of Toxicology. 33: 47S-60S. PMID 25568165 DOI: 10.1177/1091581814563524  0.88
2014 Johnson W, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD, Liebler DC, Marks JG, Shank RC, Slaga TJ, Snyder PW, Andersen FA. Safety assessment of Tin(IV) oxide as used in cosmetics. International Journal of Toxicology. 33: 40S-6S. PMID 25568164 DOI: 10.1177/1091581814559309  0.88
2014 Burnett C, Heldreth B, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD, Liebler DC, Marks JG, Shank RC, Slaga TJ, Snyder PW, Andersen FA. Safety assessment of animal- and plant-derived amino acids as used in cosmetics. International Journal of Toxicology. 33: 5S-12S. PMID 25323218 DOI: 10.1177/1091581814554774  0.88
2014 Becker LC, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD, Liebler DC, Marks JG, Shank RC, Slaga TJ, Snyder PW, Andersen FA. Amended safety assessment of Hypericum perforatum-derived ingredients as used in cosmetics. International Journal of Toxicology. 33: 5S-23S. PMID 25297909 DOI: 10.1177/1091581814533354  0.88
2014 Fiume MM, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD, Liebler DC, Marks JG, Shank RC, Slaga TJ, Snyder PW, Andersen FA. Safety assessment of Vitis vinifera (grape)-derived ingredients as used in cosmetics. International Journal of Toxicology. 33: 48S-83S. PMID 25297908 DOI: 10.1177/1091581814545247  0.88
2014 Becker LC, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD, Liebler DC, Marks JG, Shank RC, Slaga TJ, Snyder PW, Andersen FA. Safety assessment of modified terephthalate polymers as used in cosmetics. International Journal of Toxicology. 33: 36S-47S. PMID 25297907 DOI: 10.1177/1091581814537001  0.88
2014 Burnett CL, Heldreth B, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD, Liebler DC, Marks JG, Shank RC, Slaga TJ, Snyder PW, Andersen FA. Safety assessment of 6-hydroxyindole as used in cosmetics. International Journal of Toxicology. 33: 24S-35S. PMID 25297906 DOI: 10.1177/1091581814533972  0.88
2014 Fu ZD, Cui JY, Klaassen CD. Atorvastatin induces bile acid-synthetic enzyme Cyp7a1 by suppressing FXR signaling in both liver and intestine in mice. Journal of Lipid Research. 55: 2576-86. PMID 25278499 DOI: 10.1194/Jlr.M053124  1
2014 Burnett CL, Heldreth B, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD, Liebler DC, Marks JG, Shank RC, Slaga TJ, Snyder PW, Andersen FA. Safety Assessment of PEGylated oils as used in cosmetics. International Journal of Toxicology. 33: 13S-39S. PMID 25163475 DOI: 10.1177/1091581814546337  0.88
2014 Cheng X, Gu J, Klaassen CD. Adaptive hepatic and intestinal alterations in mice after deletion of NADPH-cytochrome P450 Oxidoreductase (Cpr) in hepatocytes. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 42: 1826-33. PMID 25147274 DOI: 10.1124/Dmd.114.060053  1
2014 Renaud HJ, Cui YJ, Lu H, Zhong XB, Klaassen CD. Ontogeny of hepatic energy metabolism genes in mice as revealed by RNA-sequencing. Plos One. 9: e104560. PMID 25102070 DOI: 10.1371/Journal.Pone.0104560  0.96
2014 Liu J, Lu H, Lu YF, Lei X, Cui JY, Ellis E, Strom SC, Klaassen CD. Potency of individual bile acids to regulate bile acid synthesis and transport genes in primary human hepatocyte cultures. Toxicological Sciences : An Official Journal of the Society of Toxicology. 141: 538-46. PMID 25055961 DOI: 10.1093/Toxsci/Kfu151  1
2014 Cheng X, Zhang Y, Klaassen CD. Decreased bile-acid synthesis in livers of hepatocyte-conditional NADPH-cytochrome P450 reductase-null mice results in increased bile acids in serum. The Journal of Pharmacology and Experimental Therapeutics. 351: 105-13. PMID 25034404 DOI: 10.1124/Jpet.114.216796  1
2014 Raveendran VV, Kassel KM, Smith DD, Luyendyk JP, Williams KJ, Cherian R, Reed GA, Flynn CA, Csanaky IL, Lickteig AL, Pratt-Hyatt MJ, Klaassen CD, Dileepan KN. H1-antihistamines exacerbate high-fat diet-induced hepatic steatosis in wild-type but not in apolipoprotein E knockout mice. American Journal of Physiology. Gastrointestinal and Liver Physiology. 307: G219-28. PMID 24852568 DOI: 10.1152/Ajpgi.00027.2014  0.88
2014 Qu Q, Liu J, Zhou HH, Klaassen CD. Nrf2 protects against furosemide-induced hepatotoxicity. Toxicology. 324: 35-42. PMID 24813929 DOI: 10.1016/J.Tox.2014.02.008  0.88
2014 Cazanave SC, Wang X, Zhou H, Rahmani M, Grant S, Durrant DE, Klaassen CD, Yamamoto M, Sanyal AJ. Degradation of Keap1 activates BH3-only proteins Bim and PUMA during hepatocyte lipoapoptosis. Cell Death and Differentiation. 21: 1303-12. PMID 24769730 DOI: 10.1038/Cdd.2014.49  0.88
2014 Cheng X, Vispute SG, Liu J, Cheng C, Kharitonenkov A, Klaassen CD. Fibroblast growth factor (Fgf) 21 is a novel target gene of the aryl hydrocarbon receptor (AhR). Toxicology and Applied Pharmacology. 278: 65-71. PMID 24769090 DOI: 10.1016/J.Taap.2014.04.013  1
2014 Lu YF, Liu J, Wu KC, Qu Q, Fan F, Klaassen CD. Overexpression of Nrf2 protects against microcystin-induced hepatotoxicity in mice. Plos One. 9: e93013. PMID 24667526 DOI: 10.1371/Journal.Pone.0093013  0.88
2014 Zhang Y, Limaye PB, Renaud HJ, Klaassen CD. Effect of various antibiotics on modulation of intestinal microbiota and bile acid profile in mice. Toxicology and Applied Pharmacology. 277: 138-45. PMID 24657338 DOI: 10.1016/J.Taap.2014.03.009  1
2014 Clarke JD, Hardwick RN, Lake AD, Lickteig AJ, Goedken MJ, Klaassen CD, Cherrington NJ. Synergistic interaction between genetics and disease on pravastatin disposition. Journal of Hepatology. 61: 139-47. PMID 24613363 DOI: 10.1016/J.Jhep.2014.02.021  0.88
2014 Renaud HJ, Cui JY, Lu H, Klaassen CD. Effect of diet on expression of genes involved in lipid metabolism, oxidative stress, and inflammation in mouse liver-insights into mechanisms of hepatic steatosis. Plos One. 9: e88584. PMID 24551121 DOI: 10.1371/Journal.Pone.0088584  1
2014 Wu KC, McDonald PR, Liu J, Klaassen CD. Screening of natural compounds as activators of the keap1-nrf2 pathway. Planta Medica. 80: 97-104. PMID 24310212 DOI: 10.1055/S-0033-1351097  0.88
2014 Fu ZD, Klaassen CD. Short-term calorie restriction feminizes the mRNA profiles of drug metabolizing enzymes and transporters in livers of mice. Toxicology and Applied Pharmacology. 274: 137-46. PMID 24240088 DOI: 10.1016/J.Taap.2013.11.003  1
2014 Liu K, Li F, Lu J, Gao Z, Klaassen CD, Ma X. Role of CYP3A in isoniazid metabolism in vivo. Drug Metabolism and Pharmacokinetics. 29: 219-22. PMID 24172716 DOI: 10.2133/Dmpk.Dmpk-13-Nt-089  0.8
2014 Watkins JB, Klaassen CD. Absorption, Enterohepatic Circulation and Fecal Excretion of Toxicants Reference Module in Biomedical Research. DOI: 10.1016/B978-0-12-801238-3.02122-X  0.88
2013 Rockwell CE, Turley AE, Cheng X, Fields PE, Klaassen CD. Acute Immunotoxic Effects of Perfluorononanoic Acid (PFNA) in C57BL/6 Mice. Clinical & Experimental Pharmacology. PMID 25568816 DOI: 10.4172/2161-1459.S4-002  1
2013 Boyer IJ, Heldreth B, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD, Liebler DC, Marks JG, Shank RC, Slaga TJ, Snyder PW, Andersen FA. Amended safety assessment of formaldehyde and methylene glycol as used in cosmetics. International Journal of Toxicology. 32: 5S-32S. PMID 24335968 DOI: 10.1177/1091581813511831  0.88
2013 Burnett CL, Heldreth B, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD, Liebler DC, Marks JG, Shank RC, Slaga TJ, Snyder PW, Andersen FA. Safety assessment of α-amino acids as used in cosmetics. International Journal of Toxicology. 32: 41S-64S. PMID 24335967 DOI: 10.1177/1091581813507090  0.88
2013 Becker LC, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD, Liebler DC, Marks JG, Shank RC, Slaga TJ, Snyder PW, Andersen FA. Safety assessment of ammonium hectorites as used in cosmetics. International Journal of Toxicology. 32: 33S-40S. PMID 24335966 DOI: 10.1177/1091581813507722  0.88
2013 Fu ZD, Klaassen CD. Increased bile acids in enterohepatic circulation by short-term calorie restriction in male mice. Toxicology and Applied Pharmacology. 273: 680-90. PMID 24183703 DOI: 10.1016/J.Taap.2013.10.020  1
2013 Becker LC, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD, Liebler DC, Marks JG, Shank RC, Slaga TJ, Snyder PW, Andersen FA. Safety assessment of borosilicate glasses as used in cosmetics. International Journal of Toxicology. 32: 65S-72S. PMID 24174476 DOI: 10.1177/1091581813507089  0.88
2013 Johnson W, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD, Liebler D, Marks JG, Shank RC, Slaga TJ, Snyder PW, Andersen FA. Safety assessment of alkyl glyceryl ethers as used in cosmetics. International Journal of Toxicology. 32: 5S-21S. PMID 24174475 DOI: 10.1177/1091581813497766  0.88
2013 Fiume MM, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD, Liebler DC, Marks JG, Shank RC, Slaga TJ, Snyder PW, Andersen FA. Safety assessment of bis-diglyceryl polyacyladipate-2 and bis-diglyceryl polyacyladipate-1 as used in cosmetics. International Journal of Toxicology. 32: 56S-64S. PMID 24174474 DOI: 10.1177/1091581813504596  0.88
2013 Burnett CL, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD, Liebler D, Marks JG, Shank RC, Slaga TJ, Snyder PW, Andersen FA. Safety assessment of lauriminodipropionic acid, sodium lauriminodipropionate, and disodium lauriminodipropionate as used in cosmetics. International Journal of Toxicology. 32: 49S-55S. PMID 24174473 DOI: 10.1177/1091581813497765  0.88
2013 Fiume MM, Heldreth B, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD, Liebler D, Marks JG, Shank RC, Slaga TJ, Snyder PW, Andersen FA. Safety assessment of decyl glucoside and other alkyl glucosides as used in cosmetics. International Journal of Toxicology. 32: 22S-48S. PMID 24174472 DOI: 10.1177/1091581813497764  0.88
2013 Peng L, Cui JY, Yoo B, Gunewardena SS, Lu H, Klaassen CD, Zhong XB. RNA-sequencing quantification of hepatic ontogeny of phase-I enzymes in mice. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 41: 2175-86. PMID 24080161 DOI: 10.1124/Dmd.113.054635  1
2013 Liu J, Lu YF, Zhang Y, Wu KC, Fan F, Klaassen CD. Oleanolic acid alters bile acid metabolism and produces cholestatic liver injury in mice. Toxicology and Applied Pharmacology. 272: 816-24. PMID 23948738 DOI: 10.1016/J.Taap.2013.08.003  1
2013 Liu J, Wu KC, Lu YF, Ekuase E, Klaassen CD. Nrf2 protection against liver injury produced by various hepatotoxicants. Oxidative Medicine and Cellular Longevity. 2013: 305861. PMID 23766851 DOI: 10.1155/2013/305861  0.88
2013 Zhang Y, Csanaky IL, Selwyn FP, Lehman-McKeeman LD, Klaassen CD. Organic anion-transporting polypeptide 1a4 (Oatp1a4) is important for secondary bile acid metabolism. Biochemical Pharmacology. 86: 437-45. PMID 23747753 DOI: 10.1016/J.Bcp.2013.05.020  1
2013 Zhang Y, Klaassen CD. Hormonal regulation of Cyp4a isoforms in mouse liver and kidney. Xenobiotica; the Fate of Foreign Compounds in Biological Systems. 43: 1055-63. PMID 23725209 DOI: 10.3109/00498254.2013.797622  1
2013 Becker LC, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD, Liebler D, Marks JG, Shank RC, Slaga TJ, Snyder PW, Andersen FA. Safety assessment of silylates and surface-modified siloxysilicates. International Journal of Toxicology. 32: 5S-24S. PMID 23696579 DOI: 10.1177/1091581813486299  0.88
2013 Fiume MM, Heldreth B, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD, Liebler D, Marks JG, Shank RC, Slaga TJ, Snyder PW, Andersen FA. Safety assessment of triethanolamine and triethanolamine-containing ingredients as used in cosmetics. International Journal of Toxicology. 32: 59S-83S. PMID 23696578 DOI: 10.1177/1091581813488804  0.88
2013 Fiume MM, Heldreth B, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD, Liebler DC, Marks JG, Shank RC, Slaga TJ, Snyder PW, Andersen FA. Safety assessment of diethanolamides as used in cosmetics. International Journal of Toxicology. 32: 36S-58S. PMID 23696577 DOI: 10.1177/1091581813486300  0.88
2013 Burnett CL, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD, Liebler D, Marks JG, Shank RC, Slaga TJ, Snyder PW, Andersen FA. Safety assessment of 2-amino-4-hydroxyethylaminoanisole and 2-amino-4-hydroxyethylaminoanisole sulfate as used in cosmetics. International Journal of Toxicology. 32: 25S-35S. PMID 23696576 DOI: 10.1177/1091581813486301  0.88
2013 Pratt-Hyatt M, Lickteig AJ, Klaassen CD. Tissue distribution, ontogeny, and chemical induction of aldo-keto reductases in mice. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 41: 1480-7. PMID 23660342 DOI: 10.1124/Dmd.113.051904  0.68
2013 Zhang YK, Wu KC, Klaassen CD. Genetic activation of Nrf2 protects against fasting-induced oxidative stress in livers of mice. Plos One. 8: e59122. PMID 23527105 DOI: 10.1371/Journal.Pone.0059122  0.88
2013 Li F, Lu J, Cheng J, Wang L, Matsubara T, Csanaky IL, Klaassen CD, Gonzalez FJ, Ma X. Human PXR modulates hepatotoxicity associated with rifampicin and isoniazid co-therapy. Nature Medicine. 19: 418-20. PMID 23475203 DOI: 10.1038/Nm.3104  0.96
2013 Lu H, Gunewardena S, Cui JY, Yoo B, Zhong XB, Klaassen CD. RNA-sequencing quantification of hepatic ontogeny and tissue distribution of mRNAs of phase II enzymes in mice. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 41: 844-57. PMID 23382457 DOI: 10.1124/Dmd.112.050211  1
2013 Reisman SA, Ward KW, Klaassen CD, Meyer CJ. CDDO-9,11-dihydro-trifluoroethyl amide (CDDO-dhTFEA) induces hepatic cytoprotective genes and increases bile flow in rats. Xenobiotica; the Fate of Foreign Compounds in Biological Systems. 43: 571-8. PMID 23244591 DOI: 10.3109/00498254.2012.750022  0.88
2013 Zhang YK, Lu H, Klaassen CD. Expression of human CAR splicing variants in BAC-transgenic mice. Toxicological Sciences : An Official Journal of the Society of Toxicology. 132: 142-50. PMID 23152187 DOI: 10.1093/Toxsci/Kfs321  0.88
2012 'Becker LC, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD, Liebler D, Marks JG, Shank RC, Slaga TJ, Snyder PW, Andersen FA. Safety assessment of alkyl benzoates as used in cosmetics. International Journal of Toxicology. 31: 342S-72S. PMID 23283706 DOI: 10.1177/1091581812467379  0.88
2012 Becker LC, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD, Liebler D, Marks JG, Shank RC, Slaga TJ, Snyder PW, Andersen FA. Safety assessment of trimoniums as used in cosmetics. International Journal of Toxicology. 31: 296S-341S. PMID 23283705 DOI: 10.1177/1091581812467378  0.88
2012 Johnson W, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD, Liebler D, Marks JG, Shank RC, Slaga TJ, Snyder PW, Andersen FA. Safety assessment of isoparaffins as used in cosmetics. International Journal of Toxicology. 31: 269S-95S. PMID 23283704 DOI: 10.1177/1091581812463087  0.88
2012 Fiume MM, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD, Liebler D, Marks JG, Shank RC, Slaga TJ, Snyder PW, Andersen FA. Safety assessment of propylene glycol, tripropylene glycol, and PPGs as used in cosmetics. International Journal of Toxicology. 31: 245S-60S. PMID 23064775 DOI: 10.1177/1091581812461381  0.88
2012 Fiume MM, Heldreth B, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD, Liebler D, Marks JG, Shank RC, Slaga TJ, Snyder PW, Andersen FA. Safety assessment of alkyl PEG ethers as used in cosmetics. International Journal of Toxicology. 31: 169S-244S. PMID 23064774 DOI: 10.1177/1091581812444141  0.88
2012 Johnson W, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD, Liebler D, Marks JG, Shank RC, Slaga TJ, Snyder PW, Andersen FA. Safety assessment of 1,2-glycols as used in cosmetics. International Journal of Toxicology. 31: 147S-68S. PMID 23064773 DOI: 10.1177/1091581812460409  0.88
2012 Fiume MM, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD, Liebler D, Marks JG, Shank RC, Slaga TJ, Snyder PW, Andersen FA. Safety assessment of stearyl heptanoate and related stearyl alkanoates as used in cosmetics. International Journal of Toxicology. 31: 141S-6S. PMID 23064772 DOI: 10.1177/1091581812460408  0.88
2012 Wu KC, McDonald PR, Liu JJ, Chaguturu R, Klaassen CD. Implementation of a high-throughput screen for identifying small molecules to activate the Keap1-Nrf2-ARE pathway. Plos One. 7: e44686. PMID 23056183 DOI: 10.1371/Journal.Pone.0044686  0.88
2012 Zhang YK, Wu KC, Liu J, Klaassen CD. Nrf2 deficiency improves glucose tolerance in mice fed a high-fat diet. Toxicology and Applied Pharmacology. 264: 305-14. PMID 23017736 DOI: 10.1016/J.Taap.2012.09.014  0.88
2012 Xu YQ, Zhang D, Jin T, Cai DJ, Wu Q, Lu Y, Liu J, Klaassen CD. Diurnal variation of hepatic antioxidant gene expression in mice. Plos One. 7: e44237. PMID 22952936 DOI: 10.1371/Journal.Pone.0044237  0.88
2012 Aleksunes LM, Yeager RL, Wen X, Cui JY, Klaassen CD. Repression of hepatobiliary transporters and differential regulation of classic and alternative bile acid pathways in mice during pregnancy. Toxicological Sciences : An Official Journal of the Society of Toxicology. 130: 257-68. PMID 22903823 DOI: 10.1093/Toxsci/Kfs248  0.88
2012 Burnett CL, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD, Liebler D, Marks JG, Shank RC, Slaga TJ, Snyder PW, Andersen FA. Final report of the Cosmetic Ingredient Review Expert Panel on the safety assessment of cocamidopropyl betaine (CAPB). International Journal of Toxicology. 31: 77S-111S. PMID 22869896 DOI: 10.1177/1091581812447202  0.88
2012 Fiume MM, Heldreth B, Eldreth H, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD, Liebler D, Marks JG, Shank RC, Slaga TJ, Snyder PW, Andersen FA. Final report of the Cosmetic Ingredient Review Expert Panel on the safety assessment of dicarboxylic acids, salts, and esters. International Journal of Toxicology. 31: 5S-76S. PMID 22869895 DOI: 10.1177/1091581812447203  0.88
2012 Heldreth B, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD, Liebler D, Marks JG, Shank RC, Slaga TJ, Snyder PW, Andersen FA. Final report of the Cosmetic Ingredient Review Expert Panel on the safety assessment of methyl acetate. International Journal of Toxicology. 31: 112S-36S. PMID 22869894 DOI: 10.1177/1091581812444142  0.88
2012 Wu KC, Cui JY, Klaassen CD. Effect of graded Nrf2 activation on phase-I and -II drug metabolizing enzymes and transporters in mouse liver. Plos One. 7: e39006. PMID 22808024 DOI: 10.1371/Journal.Pone.0039006  1
2012 Lu H, Cui JY, Gunewardena S, Yoo B, Zhong XB, Klaassen CD. Hepatic ontogeny and tissue distribution of mRNAs of epigenetic modifiers in mice using RNA-sequencing. Epigenetics. 7: 914-29. PMID 22772165 DOI: 10.4161/Epi.21113  1
2012 Wu KC, Zhang Y, Klaassen CD. Nrf2 protects against diquat-induced liver and lung injury. Free Radical Research. 46: 1220-9. PMID 22762311 DOI: 10.3109/10715762.2012.700709  1
2012 Wu KC, Liu JJ, Klaassen CD. Nrf2 activation prevents cadmium-induced acute liver injury. Toxicology and Applied Pharmacology. 263: 14-20. PMID 22677785 DOI: 10.1016/J.Taap.2012.05.017  0.88
2012 Cheng X, Klaassen CD. Hormonal and chemical regulation of paraoxonases in mice. The Journal of Pharmacology and Experimental Therapeutics. 342: 688-95. PMID 22653878 DOI: 10.1124/Jpet.112.194803  1
2012 Wu KC, Liu J, Klaassen CD. Role of Nrf2 in preventing ethanol-induced oxidative stress and lipid accumulation. Toxicology and Applied Pharmacology. 262: 321-9. PMID 22627062 DOI: 10.1016/J.Taap.2012.05.010  0.88
2012 Kong B, Csanaky IL, Aleksunes LM, Patni M, Chen Q, Ma X, Jaeschke H, Weir S, Broward M, Klaassen CD, Guo GL. Gender-specific reduction of hepatic Mrp2 expression by high-fat diet protects female mice from ANIT toxicity. Toxicology and Applied Pharmacology. 261: 189-95. PMID 22521610 DOI: 10.1016/J.Taap.2012.04.001  0.96
2012 Zhang Y, Limaye PB, Lehman-McKeeman LD, Klaassen CD. Dysfunction of organic anion transporting polypeptide 1a1 alters intestinal bacteria and bile acid metabolism in mice. Plos One. 7: e34522. PMID 22496825 DOI: 10.1371/Journal.Pone.0034522  1
2012 Aleksunes LM, Klaassen CD. Coordinated regulation of hepatic phase I and II drug-metabolizing genes and transporters using AhR-, CAR-, PXR-, PPARα-, and Nrf2-null mice. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 40: 1366-79. PMID 22496397 DOI: 10.1124/Dmd.112.045112  0.56
2012 Kong B, Wang L, Chiang JY, Zhang Y, Klaassen CD, Guo GL. Mechanism of tissue-specific farnesoid X receptor in suppressing the expression of genes in bile-acid synthesis in mice. Hepatology (Baltimore, Md.). 56: 1034-43. PMID 22467244 DOI: 10.1002/Hep.25740  1
2012 Zhang Y, Csanaky IL, Cheng X, Lehman-McKeeman LD, Klaassen CD. Organic anion transporting polypeptide 1a1 null mice are sensitive to cholestatic liver injury. Toxicological Sciences : An Official Journal of the Society of Toxicology. 127: 451-62. PMID 22461449 DOI: 10.1093/Toxsci/Kfs123  1
2012 Cui JY, Gunewardena SS, Yoo B, Liu J, Renaud HJ, Lu H, Zhong XB, Klaassen CD. RNA-Seq reveals different mRNA abundance of transporters and their alternative transcript isoforms during liver development. Toxicological Sciences : An Official Journal of the Society of Toxicology. 127: 592-608. PMID 22454430 DOI: 10.1093/Toxsci/Kfs107  1
2012 Cui JY, Renaud HJ, Klaassen CD. Ontogeny of novel cytochrome P450 gene isoforms during postnatal liver maturation in mice. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 40: 1226-37. PMID 22446519 DOI: 10.1124/Dmd.111.042697  1
2012 Fu ZD, Csanaky IL, Klaassen CD. Effects of aging on mRNA profiles for drug-metabolizing enzymes and transporters in livers of male and female mice. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 40: 1216-25. PMID 22446518 DOI: 10.1124/Dmd.111.044461  1
2012 Peng L, Yoo B, Gunewardena SS, Lu H, Klaassen CD, Zhong XB. RNA sequencing reveals dynamic changes of mRNA abundance of cytochromes P450 and their alternative transcripts during mouse liver development. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 40: 1198-209. PMID 22434873 DOI: 10.1124/Dmd.112.045088  0.88
2012 Zhang Y, Cheng X, Aleksunes L, Klaassen CD. Transcription factor-mediated regulation of carboxylesterase enzymes in livers of mice. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 40: 1191-7. PMID 22429928 DOI: 10.1124/Dmd.111.043877  1
2012 Fu ZD, Csanaky IL, Klaassen CD. Gender-divergent profile of bile acid homeostasis during aging of mice. Plos One. 7: e32551. PMID 22403674 DOI: 10.1371/Journal.Pone.0032551  1
2012 Cui JY, Aleksunes LM, Tanaka Y, Fu ZD, Guo Y, Guo GL, Lu H, Zhong XB, Klaassen CD. Bile acids via FXR initiate the expression of major transporters involved in the enterohepatic circulation of bile acids in newborn mice. American Journal of Physiology. Gastrointestinal and Liver Physiology. 302: G979-96. PMID 22268101 DOI: 10.1152/Ajpgi.00370.2011  1
2012 Rockwell CE, Zhang M, Fields PE, Klaassen CD. Th2 skewing by activation of Nrf2 in CD4(+) T cells. Journal of Immunology (Baltimore, Md. : 1950). 188: 1630-7. PMID 22250088 DOI: 10.4049/Jimmunol.1101712  0.88
2012 Haeusler RA, Pratt-Hyatt M, Welch CL, Klaassen CD, Accili D. Impaired generation of 12-hydroxylated bile acids links hepatic insulin signaling with dyslipidemia. Cell Metabolism. 15: 65-74. PMID 22197325 DOI: 10.1016/J.Cmet.2011.11.010  0.88
2012 Martin LA, Wilson DT, Reuhl KR, Gallo MA, Klaassen CD. Polychlorinated biphenyl congeners that increase the glucuronidation and biliary excretion of thyroxine are distinct from the congeners that enhance the serum disappearance of thyroxine. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 40: 588-95. PMID 22187485 DOI: 10.1124/Dmd.111.042796  0.88
2012 Li T, Francl JM, Boehme S, Ochoa A, Zhang Y, Klaassen CD, Erickson SK, Chiang JY. Glucose and insulin induction of bile acid synthesis: mechanisms and implication in diabetes and obesity. The Journal of Biological Chemistry. 287: 1861-73. PMID 22144677 DOI: 10.1074/Jbc.M111.305789  1
2012 Zhang Y, Hong JY, Rockwell CE, Copple BL, Jaeschke H, Klaassen CD. Effect of bile duct ligation on bile acid composition in mouse serum and liver. Liver International : Official Journal of the International Association For the Study of the Liver. 32: 58-69. PMID 22098667 DOI: 10.1111/J.1478-3231.2011.02662.X  0.88
2012 Guo Y, Chen Y, Tan ZR, Klaassen CD, Zhou HH. Repeated administration of berberine inhibits cytochromes P450 in humans. European Journal of Clinical Pharmacology. 68: 213-7. PMID 21870106 DOI: 10.1007/S00228-011-1108-2  0.84
2011 Bergfeld WF, Belsito DV, Klaassen CD, Hill R, Liebler D, Marks JG, Shank RC, Slaga TJ, Snyder PW, Andersen FA. Safety assessment of xylene sulfonic acid, toluene sulfonic acid, and alkyl aryl sulfonate hydrotropes as used in cosmetics. International Journal of Toxicology. 30: 270S-83S. PMID 22247238 DOI: 10.1177/1091581811429085  0.88
2011 Johnson W, Heldreth B, Bergfeld WF, Belsito DV, Klaassen CD, Hill R, Liebler D, Marks JG, Shank RC, Slaga TJ, Snyder PW, Andersen FA. Final report of the Cosmetic Ingredient Review Expert Panel on the safety assessment of pelargonic acid (nonanoic acid) and nonanoate esters. International Journal of Toxicology. 30: 228S-69S. PMID 22247237 DOI: 10.1177/1091581811428980  0.88
2011 Johnson W, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD, Liebler DC, Marks JG, Shank RC, Slaga TJ, Snyder PW, Andersen FA. Safety assessment of cyclomethicone, cyclotetrasiloxane, cyclopentasiloxane, cyclohexasiloxane, and cycloheptasiloxane. International Journal of Toxicology. 30: 149S-227S. PMID 22247236 DOI: 10.1177/1091581811428184  0.88
2011 Burnett CL, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD, Liebler DC, Marks JG, Shank RC, Slaga TJ, Snyder PW, Andersen FA. Final report of the Amended Safety Assessment of PVM/MA copolymer and its related salts and esters as used in cosmetics. International Journal of Toxicology. 30: 128S-44S. PMID 22068629 DOI: 10.1177/1091581811407934  0.88
2011 Renaud HJ, Cui JY, Khan M, Klaassen CD. Tissue distribution and gender-divergent expression of 78 cytochrome P450 mRNAs in mice. Toxicological Sciences : An Official Journal of the Society of Toxicology. 124: 261-77. PMID 21920951 DOI: 10.1093/Toxsci/Kfr240  1
2011 Guo Y, Pope C, Cheng X, Zhou H, Klaassen CD. Dose-response of berberine on hepatic cytochromes P450 mRNA expression and activities in mice. Journal of Ethnopharmacology. 138: 111-8. PMID 21920422 DOI: 10.1016/J.Jep.2011.08.058  1
2011 Zhang Y, Csanaky IL, Lehman-McKeeman LD, Klaassen CD. Loss of organic anion transporting polypeptide 1a1 increases deoxycholic acid absorption in mice by increasing intestinal permeability. Toxicological Sciences : An Official Journal of the Society of Toxicology. 124: 251-60. PMID 21914718 DOI: 10.1093/Toxsci/Kfr236  1
2011 Pacyniak E, Hagenbuch B, Klaassen CD, Lehman-McKeeman L, Guo GL. Organic anion transporting polypeptides in the hepatic uptake of PBDE congeners in mice. Toxicology and Applied Pharmacology. 257: 23-31. PMID 21884716 DOI: 10.1016/J.Taap.2011.08.014  0.76
2011 Lu H, Cui W, Klaassen CD. Nrf2 protects against 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced oxidative injury and steatohepatitis. Toxicology and Applied Pharmacology. 256: 122-35. PMID 21846477 DOI: 10.1016/J.Taap.2011.07.019  0.88
2011 Guo Y, Li F, Ma X, Cheng X, Zhou H, Klaassen CD. CYP2D plays a major role in berberine metabolism in liver of mice and humans. Xenobiotica; the Fate of Foreign Compounds in Biological Systems. 41: 996-1005. PMID 21787170 DOI: 10.3109/00498254.2011.597456  1
2011 Wu KC, Cui JY, Klaassen CD. Beneficial role of Nrf2 in regulating NADPH generation and consumption. Toxicological Sciences : An Official Journal of the Society of Toxicology. 123: 590-600. PMID 21775727 DOI: 10.1093/Toxsci/Kfr183  1
2011 Becker LC, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD, Liebler DC, Marks JG, Shank RC, Slaga TJ, Snyder PW, Andersen FA. Final report of the Cosmetic Ingredient Review Expert Panel safety assessment of polymethyl methacrylate (PMMA), methyl methacrylate crosspolymer, and methyl methacrylate/glycol dimethacrylate crosspolymer. International Journal of Toxicology. 30: 54S-65S. PMID 21772027 DOI: 10.1177/1091581811407352  0.88
2011 Johnson W, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD, Liebler DC, Marks JG, Shank RC, Slaga TJ, Snyder PW, Andersen FA. Amended safety assessment of Sesamum indicum (sesame) seed oil, hydrogenated sesame seed oil, Sesamum indicum (sesame) oil unsaponifiables, and sodium sesameseedate. International Journal of Toxicology. 30: 40S-53S. PMID 21772026 DOI: 10.1177/1091581811406987  0.88
2011 Andersen FA, Bergfeld WF, Belsito DV, Klaassen CD, Marks JG, Shank RC, Slaga TJ, Snyder PW. Final report of the safety assessment of cosmetic ingredients derived from Zea mays (corn). International Journal of Toxicology. 30: 17S-39S. PMID 21772025 DOI: 10.1177/1091581811403832  0.88
2011 Burnett CL, Bergfeld WF, Belsito DV, Klaassen CD, Marks JG, Shank RC, Slaga TJ, Snyder PW, Andersen FA. Final report on the safety assessment of Cocos nucifera (coconut) oil and related ingredients. International Journal of Toxicology. 30: 5S-16S. PMID 21772024 DOI: 10.1177/1091581811400636  0.88
2011 Song P, Zhang Y, Klaassen CD. Dose-response of five bile acids on serum and liver bile Acid concentrations and hepatotoxicty in mice. Toxicological Sciences : An Official Journal of the Society of Toxicology. 123: 359-67. PMID 21747115 DOI: 10.1093/Toxsci/Kfr177  1
2011 Gong L, Aranibar N, Han YH, Zhang Y, Lecureux L, Bhaskaran V, Khandelwal P, Klaassen CD, Lehman-McKeeman LD. Characterization of organic anion-transporting polypeptide (Oatp) 1a1 and 1a4 null mice reveals altered transport function and urinary metabolomic profiles Toxicological Sciences. 122: 587-597. PMID 21561886 DOI: 10.1093/Toxsci/Kfr114  0.88
2011 Klaassen CD, Lu H, Cui JY. Epigenetic regulation of drug processing genes. Toxicology Mechanisms and Methods. 21: 312-24. PMID 21495869 DOI: 10.3109/15376516.2011.562758  1
2011 Zhang YK, Guo GL, Klaassen CD. Diurnal variations of mouse plasma and hepatic bile acid concentrations as well as expression of biosynthetic enzymes and transporters. Plos One. 6: e16683. PMID 21346810 DOI: 10.1371/Journal.Pone.0016683  0.88
2011 Csanaky IL, Lu H, Zhang Y, Ogura K, Choudhuri S, Klaassen CD. Organic anion-transporting polypeptide 1b2 (Oatp1b2) is important for the hepatic uptake of unconjugated bile acids: Studies in Oatp1b2-null mice. Hepatology (Baltimore, Md.). 53: 272-81. PMID 20949553 DOI: 10.1002/Hep.23984  1
2010 Becker LC, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD, Liebler DC, Marks JG, Shank RC, Slaga TJ, Snyder PW, Andersen FA. Amended safety assessment of dodecylbenzenesulfonate, decylbenzenesulfonate, and tridecylbenzenesulfonate salts as used in cosmetics. International Journal of Toxicology. 29: 288S-305. PMID 21164075 DOI: 10.1177/1091581810386124  0.88
2010 Andersen FA, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD, Liebler DC, Marks JG, Shank RC, Slaga TJ, Snyder PW. Final amended safety assessment of hydroquinone as used in cosmetics. International Journal of Toxicology. 29: 274S-87. PMID 21164074 DOI: 10.1177/1091581810385957  0.88
2010 Burnett CL, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD, Liebler DC, Marks JG, Shank RC, Slaga TJ, Snyder PW, Andersen FA. Final report of the safety assessment of Kojic acid as used in cosmetics. International Journal of Toxicology. 29: 244S-73. PMID 21164073 DOI: 10.1177/1091581810385956  0.88
2010 Andersen FA, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD, Liebler DC, Marks JG, Shank RC, Slaga TJ, Snyder PW. Final report of the Cosmetic Ingredient Review Expert Panel amended safety assessment of Calendula officinalis-derived cosmetic ingredients. International Journal of Toxicology. 29: 221S-43. PMID 21164072 DOI: 10.1177/1091581810384883  0.88
2010 Cui JY, Gunewardena SS, Rockwell CE, Klaassen CD. ChIPing the cistrome of PXR in mouse liver. Nucleic Acids Research. 38: 7943-63. PMID 20693526 DOI: 10.1093/Nar/Gkq654  0.88
2010 Zhang Y, Klaassen CD. Effects of feeding bile acids and a bile acid sequestrant on hepatic bile acid composition in mice. Journal of Lipid Research. 51: 3230-42. PMID 20671298 DOI: 10.1194/Jlr.M007641  1
2010 Burnett CL, Bergfeld WF, Belsito DV, Klaassen CD, Marks JG, Shank RC, Slaga TJ, Snyder PW, Alan Andersen F. Final report of the safety assessment of methylisothiazolinone. International Journal of Toxicology. 29: 187S-213S. PMID 20634507 DOI: 10.1177/1091581810374651  0.88
2010 Becker LC, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD, Marks JG, Shank RC, Slaga TJ, Snyder PW, Alan Andersen F. Final report of the amended safety assessment of myristic acid and its salts and esters as used in cosmetics. International Journal of Toxicology. 29: 162S-86S. PMID 20634506 DOI: 10.1177/1091581810374127  0.88
2010 Robinson VC, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD, Marks JG, Shank RC, Slaga TJ, Snyder PW, Alan Andersen F. Final report of the amended safety assessment of sodium laureth sulfate and related salts of sulfated ethoxylated alcohols. International Journal of Toxicology. 29: 151S-61S. PMID 20634505 DOI: 10.1177/1091581810373151  0.88
2010 Diamante C, Fiume MZ, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD, Liebler DC, Marks JG, Shank RC, Slaga TJ, Snyder PW, Alan Andersen F. Final safety assessment of thiodipropionic acid and its dialkyl esters as used in cosmetics. International Journal of Toxicology. 29: 137S-50S. PMID 20634504 DOI: 10.1177/1091581810373150  0.88
2010 Aleksunes LM, Goedken MJ, Rockwell CE, Thomale J, Manautou JE, Klaassen CD. Transcriptional regulation of renal cytoprotective genes by Nrf2 and its potential use as a therapeutic target to mitigate cisplatin-induced nephrotoxicity. The Journal of Pharmacology and Experimental Therapeutics. 335: 2-12. PMID 20605904 DOI: 10.1124/Jpet.110.170084  0.88
2010 Fiume M, Bergfeld WF, Belsito DV, Klaassen CD, Marks JG, Shank RC, Slaga TJ, Snyder PW, Alan Andersen F. Final report on the safety assessment of sodium cetearyl sulfate and related alkyl sulfates as used in cosmetics. International Journal of Toxicology. 29: 115S-32S. PMID 20448271 DOI: 10.1177/1091581810364665  0.88
2010 Becker LC, Bergfeld WF, Belsito DV, Klaassen CD, Hill R, Leibler D, Marks JG, Shank RC, Slaga TJ, Snyder PW, Alan Andersen F. Final report of the amended safety assessment of Quaternium-15 as used in cosmetics. International Journal of Toxicology. 29: 98S-114S. PMID 20448270 DOI: 10.1177/1091581810363915  0.88
2010 Becker LC, Bergfeld WF, Belsito DV, Klaassen CD, Marks JG, Shank RC, Slaga TJ, Snyder PW, Alan Andersen F. Final report of the safety assessment of allantoin and its related complexes. International Journal of Toxicology. 29: 84S-97S. PMID 20448269 DOI: 10.1177/1091581810362805  0.88
2010 Burnett CL, Bergfeld WF, Belsito DV, Klaassen CD, Marks JG, Shank RC, Slaga TJ, Snyder PW, Alan Andersen F. Final amended report of the safety assessment of toluene-2,5-diamine, toluene-2,5-diamine sulfate, and toluene-3,4-diamine as used in cosmetics. International Journal of Toxicology. 29: 61S-83S. PMID 20448268 DOI: 10.1177/1091581810361964  0.88
2010 Cui JY, Choudhuri S, Knight TR, Klaassen CD. Genetic and epigenetic regulation and expression signatures of glutathione S-transferases in developing mouse liver. Toxicological Sciences : An Official Journal of the Society of Toxicology. 116: 32-43. PMID 20395309 DOI: 10.1093/Toxsci/Kfq115  1
2010 Zhang YK, Saupe KW, Klaassen CD. Energy restriction does not compensate for the reduced expression of hepatic drug-processing genes in mice with aging. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 38: 1122-31. PMID 20382754 DOI: 10.1124/Dmd.110.032599  0.88
2010 Choudhuri S, Cui Y, Klaassen CD. Molecular targets of epigenetic regulation and effectors of environmental influences. Toxicology and Applied Pharmacology. 245: 378-93. PMID 20381512 DOI: 10.1016/J.Taap.2010.03.022  0.56
2010 Zhang YK, Yeager RL, Tanaka Y, Klaassen CD. Enhanced expression of Nrf2 in mice attenuates the fatty liver produced by a methionine- and choline-deficient diet. Toxicology and Applied Pharmacology. 245: 326-34. PMID 20350562 DOI: 10.1016/J.Taap.2010.03.016  0.88
2010 Staudinger JL, Xu C, Cui YJ, Klaassen CD. Nuclear receptor-mediated regulation of carboxylesterase expression and activity. Expert Opinion On Drug Metabolism & Toxicology. 6: 261-71. PMID 20163318 DOI: 10.1517/17425250903483215  0.96
2010 Klaassen CD, Reisman SA. Nrf2 the rescue: effects of the antioxidative/electrophilic response on the liver. Toxicology and Applied Pharmacology. 244: 57-65. PMID 20122946 DOI: 10.1016/J.Taap.2010.01.013  0.76
2010 Aleksunes LM, Reisman SA, Yeager RL, Goedken MJ, Klaassen CD. Nuclear factor erythroid 2-related factor 2 deletion impairs glucose tolerance and exacerbates hyperglycemia in type 1 diabetic mice. The Journal of Pharmacology and Experimental Therapeutics. 333: 140-51. PMID 20086057 DOI: 10.1124/Jpet.109.162271  0.88
2010 Lu H, Li Y, Zhong X, Klaassen CD. Abstract 4865: Inhibition of histone methyltransferase G9a as a promising new target for the treatment of liver cancer Cancer Research. 70: 4865-4865. DOI: 10.1158/1538-7445.Am10-4865  0.88
2009 Robinson V, Bergfeld WF, Belsito DV, Klaassen CD, Marks JG, Shank RC, Slaga TJ, Snyder PW, Alan Andersen F. Amended safety assessment of tall oil acid, sodium tallate, potassium tallate, and ammonium tallate. International Journal of Toxicology. 28: 252S-8S. PMID 20086195 DOI: 10.1177/1091581809354652  0.88
2009 Burnett CL, Bergfeld WF, Belsito DV, Klaassen CD, Marks JG, Shank RC, Slaga TJ, Snyder PW, Alan Andersen F. Final report on the safety assessment of amino nitrophenols as used in hair dyes. International Journal of Toxicology. 28: 217S-51S. PMID 20086194 DOI: 10.1177/1091581809354651  0.88
2009 Becker LC, Bergfeld WF, Belsito DV, Klaassen CD, Marks JG, Shank RC, Slaga TJ, Snyder PW, Alan Andersen F. Amended safety assessment of sodium picramate and picramic acid. International Journal of Toxicology. 28: 205S-16S. PMID 20086193 DOI: 10.1177/1091581809354650  0.88
2009 Diamante C, Bergfeld WF, Belsito DV, Klaassen CD, Marks JG, Shank RC, Slaga TJ, Snyder PW, Alan Andersen F. Final report on the safety assessment of Basic Violet 1, Basic Violet 3, and Basic Violet 4. International Journal of Toxicology. 28: 193S-204S. PMID 20086192 DOI: 10.1177/1091581809354649  0.88
2009 Robinson V, Bergfeld WF, Belsito DV, Klaassen CD, Marks JG, Shank RC, Slaga TJ, Snyder PW, Andersen FA. Final report on the safety assessment of Piper methysticum leaf/root/stem extract and Piper methysticum root extract. International Journal of Toxicology. 28: 175S-88S. PMID 19966149 DOI: 10.1177/1091581809350934  0.88
2009 Robinson V, Bergfeld WF, Belsito DV, Klaassen CD, Marks JG, Shank RC, Slaga TJ, Snyder PW, Andersen FA. Final report on the safety assessment of PPG-2 methyl ether, PPG-3 methyl ether, and PPG-2 methyl ether acetate. International Journal of Toxicology. 28: 162S-74S. PMID 19966148 DOI: 10.1177/1091581809350933  0.88
2009 Burnett CL, Bergfeld WF, Belsito DV, Klaassen CD, Marks JG, Shank RC, Slaga TJ, Snyder PW, Andersen FA. Final amended report on safety assessment on aminomethyl propanol and aminomethyl propanediol. International Journal of Toxicology. 28: 141S-61S. PMID 19966147 DOI: 10.1177/1091581809350932  0.88
2009 Cheng X, Klaassen CD. Tissue distribution, ontogeny, and hormonal regulation of xenobiotic transporters in mouse kidneys. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 37: 2178-85. PMID 19679677 DOI: 10.1124/Dmd.109.027177  1
2009 Burnett CL, Bergfeld WF, Belsito DV, Klaassen CD, Marks JG, Shank RC, Slaga TJ, Snyder PW, Andersen FA. Final amended report on the safety assessment of Ammonium Thioglycolate, Butyl Thioglycolate, Calcium Thioglycolate, Ethanolamine Thioglycolate, Ethyl Thioglycolate, Glyceryl Thioglycolate, Isooctyl Thioglycolate, Isopropyl Thioglycolate, Magnesium Thioglycolate, Methyl Thioglycolate, Potassium Thioglycolate, Sodium Thioglycolate, and Thioglycolic Acid. International Journal of Toxicology. 28: 68-133. PMID 19636068 DOI: 10.1177/1091581809339890  0.88
2009 Becker LC, Bergfeld WF, Belsito DV, Klaassen CD, Marks JG, Shank RC, Slaga TJ, Snyder PW, Andersen FA. Final report of the safety assessment of hyaluronic acid, potassium hyaluronate, and sodium hyaluronate. International Journal of Toxicology. 28: 5-67. PMID 19636067 DOI: 10.1177/1091581809337738  0.88
2009 Cui YJ, Yeager RL, Zhong XB, Klaassen CD. Ontogenic expression of hepatic Ahr mRNA is associated with histone H3K4 di-methylation during mouse liver development. Toxicology Letters. 189: 184-90. PMID 19481593 DOI: 10.1016/J.Toxlet.2009.05.017  0.88
2009 Aleksunes LM, Yeager RL, Klaassen CD. Application of multivariate statistical procedures to identify transcription factors that correlate with MRP2, 3, and 4 mRNA in adult human livers Xenobiotica. 39: 514-522. PMID 19480556 DOI: 10.1080/00498250902952514  0.88
2009 Yeager RL, Reisman SA, Aleksunes LM, Klaassen CD. Introducing the "TCDD-inducible AhR-Nrf2 gene battery". Toxicological Sciences : An Official Journal of the Society of Toxicology. 111: 238-46. PMID 19474220 DOI: 10.1093/Toxsci/Kfp115  0.88
2009 Beilke LD, Aleksunes LM, Olson ER, Besselsen DG, Klaassen CD, Dvorak K, Cherrington NJ. Decreased apoptosis during CAR-mediated hepatoprotection against lithocholic acid-induced liver injury in mice. Toxicology Letters. 188: 38-44. PMID 19433268 DOI: 10.1016/J.Toxlet.2009.03.005  0.88
2009 Cui YJ, Aleksunes LM, Tanaka Y, Goedken MJ, Klaassen CD. Compensatory induction of liver efflux transporters in response to ANIT-induced liver injury is impaired in FXR-null mice. Toxicological Sciences : An Official Journal of the Society of Toxicology. 110: 47-60. PMID 19407337 DOI: 10.1093/Toxsci/Kfp094  0.96
2009 Reisman SA, Buckley DB, Tanaka Y, Klaassen CD. CDDO-Im protects from acetaminophen hepatotoxicity through induction of Nrf2-dependent genes. Toxicology and Applied Pharmacology. 236: 109-14. PMID 19371629 DOI: 10.1016/J.Taap.2008.12.024  0.96
2009 Reisman SA, Aleksunes LM, Klaassen CD. Oleanolic acid activates Nrf2 and protects from acetaminophen hepatotoxicity via Nrf2-dependent and Nrf2-independent processes. Biochemical Pharmacology. 77: 1273-82. PMID 19283895 DOI: 10.1016/J.Bcp.2008.12.028  0.76
2009 Reisman SA, Csanaky IL, Aleksunes LM, Klaassen CD. Altered disposition of acetaminophen in Nrf2-null and Keap1-knockdown mice. Toxicological Sciences : An Official Journal of the Society of Toxicology. 109: 31-40. PMID 19246624 DOI: 10.1093/Toxsci/Kfp047  0.96
2009 Reisman SA, Csanaky IL, Yeager RL, Klaassen CD. Nrf2 activation enhances biliary excretion of sulfobromophthalein by inducing glutathione-S-transferase activity. Toxicological Sciences : An Official Journal of the Society of Toxicology. 109: 24-30. PMID 19246623 DOI: 10.1093/Toxsci/Kfp045  0.96
2009 Lecureux L, Dieter MZ, Nelson DM, Watson L, Wong H, Gemzik B, Klaassen CD, Lehman-McKeeman LD. Hepatobiliary disposition of thyroid hormone in Mrp2-deficient TR- rats: reduced biliary excretion of thyroxine glucuronide does not prevent xenobiotic-induced hypothyroidism. Toxicological Sciences : An Official Journal of the Society of Toxicology. 108: 482-91. PMID 19211616 DOI: 10.1093/Toxsci/Kfp026  0.8
2009 Beilke LD, Aleksunes LM, Holland RD, Besselsen DG, Beger RD, Klaassen CD, Cherrington NJ. Constitutive androstane receptor-mediated changes in bile acid composition contributes to hepatoprotection from lithocholic acid-induced liver injury in mice. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 37: 1035-45. PMID 19196849 DOI: 10.1124/Dmd.108.023317  0.76
2009 Li Y, Cui Y, Hart SN, Klaassen CD, Zhong XB. Dynamic patterns of histone methylation are associated with ontogenic expression of the Cyp3a genes during mouse liver maturation. Molecular Pharmacology. 75: 1171-9. PMID 19188337 DOI: 10.1124/Mol.108.052993  0.72
2009 Tanaka Y, Aleksunes LM, Cui YJ, Klaassen CD. ANIT-induced intrahepatic cholestasis alters hepatobiliary transporter expression via Nrf2-dependent and independent signaling. Toxicological Sciences : An Official Journal of the Society of Toxicology. 108: 247-57. PMID 19181614 DOI: 10.1093/Toxsci/Kfp020  0.96
2009 Yang X, Zhang YK, Esterly N, Klaassen CD, Wan YJ. Gender disparity of hepatic lipid homoeostasis regulated by the circadian clock. Journal of Biochemistry. 145: 609-23. PMID 19174548 DOI: 10.1093/Jb/Mvp018  0.88
2009 Buckley DB, Klaassen CD. Induction of mouse UDP-glucuronosyltransferase mRNA expression in liver and intestine by activators of aryl-hydrocarbon receptor, constitutive androstane receptor, pregnane X receptor, peroxisome proliferator-activated receptor alpha, and nuclear factor erythroid 2-related factor 2. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 37: 847-56. PMID 19144771 DOI: 10.1124/Dmd.108.024190  0.96
2009 Buckley DB, Klaassen CD. Mechanism of gender-divergent UDP-glucuronosyltransferase mRNA expression in mouse liver and kidney. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 37: 834-40. PMID 19131521 DOI: 10.1124/Dmd.108.024224  0.96
2009 Reisman SA, Yeager RL, Yamamoto M, Klaassen CD. Increased Nrf2 activation in livers from Keap1-knockdown mice increases expression of cytoprotective genes that detoxify electrophiles more than those that detoxify reactive oxygen species. Toxicological Sciences : An Official Journal of the Society of Toxicology. 108: 35-47. PMID 19129213 DOI: 10.1093/Toxsci/Kfn267  0.88
2009 Gyamfi MA, Tanaka Y, He L, Klaassen CD, Wan YJ. Hepatic effects of a methionine-choline-deficient diet in hepatocyte RXRalpha-null mice. Toxicology and Applied Pharmacology. 234: 166-78. PMID 18952117 DOI: 10.1016/J.Taap.2008.09.022  0.8
2009 Cui YJ, Cheng X, Weaver YM, Klaassen CD. Tissue distribution, gender-divergent expression, ontogeny, and chemical induction of multidrug resistance transporter genes (Mdr1a, Mdr1b, Mdr2) in mice. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 37: 203-10. PMID 18854377 DOI: 10.1124/Dmd.108.023721  1
2009 Zhang YK, Yeager RL, Klaassen CD. Circadian expression profiles of drug-processing genes and transcription factors in mouse liver. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 37: 106-15. PMID 18838502 DOI: 10.1124/Dmd.108.024174  0.88
2008 Maher JM, Aleksunes LM, Dieter MZ, Tanaka Y, Peters JM, Manautou JE, Klaassen CD. Nrf2- and PPAR alpha-mediated regulation of hepatic Mrp transporters after exposure to perfluorooctanoic acid and perfluorodecanoic acid. Toxicological Sciences : An Official Journal of the Society of Toxicology. 106: 319-28. PMID 18757529 DOI: 10.1093/Toxsci/Kfn177  0.88
2008 Cheng X, Klaassen CD. Critical role of PPAR-alpha in perfluorooctanoic acid- and perfluorodecanoic acid-induced downregulation of Oatp uptake transporters in mouse livers. Toxicological Sciences : An Official Journal of the Society of Toxicology. 106: 37-45. PMID 18703564 DOI: 10.1093/Toxsci/Kfn161  1
2008 Cheng X, Klaassen CD. Perfluorocarboxylic acids induce cytochrome P450 enzymes in mouse liver through activation of PPAR-alpha and CAR transcription factors. Toxicological Sciences : An Official Journal of the Society of Toxicology. 106: 29-36. PMID 18648086 DOI: 10.1093/Toxsci/Kfn147  1
2008 Tanaka Y, Aleksunes LM, Goedken MJ, Chen C, Reisman SA, Manautou JE, Klaassen CD. Coordinated induction of Nrf2 target genes protects against iron nitrilotriacetate (FeNTA)-induced nephrotoxicity. Toxicology and Applied Pharmacology. 231: 364-73. PMID 18617210 DOI: 10.1016/J.Taap.2008.05.022  1
2008 Lickteig AJ, Cheng X, Augustine LM, Klaassen CD, Cherrington NJ. Tissue distribution, ontogeny and induction of the transporters Multidrug and toxin extrusion (MATE) 1 and MATE2 mRNA expression levels in mice. Life Sciences. 83: 59-64. PMID 18573474 DOI: 10.1016/J.Lfs.2008.05.004  0.88
2008 Merrell MD, Jackson JP, Augustine LM, Fisher CD, Slitt AL, Maher JM, Huang W, Moore DD, Zhang Y, Klaassen CD, Cherrington NJ. The Nrf2 activator oltipraz also activates the constitutive androstane receptor. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 36: 1716-21. PMID 18474683 DOI: 10.1124/Dmd.108.020867  0.88
2008 Lu H, Choudhuri S, Ogura K, Csanaky IL, Lei X, Cheng X, Song PZ, Klaassen CD. Characterization of organic anion transporting polypeptide 1b2-null mice: essential role in hepatic uptake/toxicity of phalloidin and microcystin-LR. Toxicological Sciences : An Official Journal of the Society of Toxicology. 103: 35-45. PMID 18296417 DOI: 10.1093/Toxsci/Kfn038  1
2008 Tanaka Y, Aleksunes LM, Yeager RL, Gyamfi MA, Esterly N, Guo GL, Klaassen CD. NF-E2-related factor 2 inhibits lipid accumulation and oxidative stress in mice fed a high-fat diet. The Journal of Pharmacology and Experimental Therapeutics. 325: 655-64. PMID 18281592 DOI: 10.1124/Jpet.107.135822  0.88
2008 Tanaka Y, Chen C, Maher JM, Klaassen CD. Ischemia-reperfusion of rat livers decreases liver and increases kidney multidrug resistance associated protein 2 (Mrp2). Toxicological Sciences : An Official Journal of the Society of Toxicology. 101: 171-8. PMID 17959626 DOI: 10.1093/Toxsci/Kfm261  0.88
2008 Aleksunes LM, Slitt AL, Maher JM, Augustine LM, Goedken MJ, Chan JY, Cherrington NJ, Klaassen CD, Manautou JE. Induction of Mrp3 and Mrp4 transporters during acetaminophen hepatotoxicity is dependent on Nrf2. Toxicology and Applied Pharmacology. 226: 74-83. PMID 17935745 DOI: 10.1016/J.Taap.2007.08.022  0.88
2007 Cheng X, Buckley D, Klaassen CD. Regulation of hepatic bile acid transporters Ntcp and Bsep expression. Biochemical Pharmacology. 74: 1665-76. PMID 17897632 DOI: 10.1016/J.Bcp.2007.08.014  1
2007 Maher JM, Dieter MZ, Aleksunes LM, Slitt AL, Guo G, Tanaka Y, Scheffer GL, Chan JY, Manautou JE, Chen Y, Dalton TP, Yamamoto M, Klaassen CD. Oxidative and electrophilic stress induces multidrug resistance-associated protein transporters via the nuclear factor-E2-related factor-2 transcriptional pathway. Hepatology (Baltimore, Md.). 46: 1597-610. PMID 17668877 DOI: 10.1002/Hep.21831  0.88
2007 Fisher CD, Augustine LM, Maher JM, Nelson DM, Slitt AL, Klaassen CD, Lehman-McKeeman LD, Cherrington NJ. Induction of drug-metabolizing enzymes by garlic and allyl sulfide compounds via activation of constitutive androstane receptor and nuclear factor E2-related factor 2. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 35: 995-1000. PMID 17353348 DOI: 10.1124/Dmd.106.014340  0.88
2007 Pacyniak EK, Cheng X, Cunningham ML, Crofton K, Klaassen CD, Guo GL. The flame retardants, polybrominated diphenyl ethers, are pregnane X receptor activators. Toxicological Sciences : An Official Journal of the Society of Toxicology. 97: 94-102. PMID 17324954 DOI: 10.1093/Toxsci/Kfm025  0.88
2007 Nakamoto K, Kidd JR, Jenison RD, Klaassen CD, Wan YJ, Kidd KK, Zhong XB. Genotyping and haplotyping of CYP2C19 functional alleles on thin-film biosensor chips. Pharmacogenetics and Genomics. 17: 103-14. PMID 17301690 DOI: 10.1097/Fpc.0B013E32801152C2  0.72
2007 Alnouti YM, Shelby MK, Chen C, Klaassen CD. Influence of phenobarbital on morphine metabolism and disposition: LC-MS/MS determination of morphine (M) and morphine-3-glucuronide (M3G) in Wistar-Kyoto rat serum, bile, and urine. Current Drug Metabolism. 8: 79-89. PMID 17266525 DOI: 10.2174/138920007779315026  1
2007 Chen C, Cheng X, Dieter MZ, Tanaka Y, Klaassen CD. Activation of cAMP-dependent signaling pathway induces mouse organic anion transporting polypeptide 2 expression. Molecular Pharmacology. 71: 1159-64. PMID 17244698 DOI: 10.1124/Mol.106.030841  1
2007 Moffit JS, Aleksunes LM, Kardas MJ, Slitt AL, Klaassen CD, Manautou JE. Role of NAD(P)H:quinone oxidoreductase 1 in clofibrate-mediated hepatoprotection from acetaminophen. Toxicology. 230: 197-206. PMID 17188792 DOI: 10.1016/J.Tox.2006.11.052  0.68
2007 Tanaka Y, Maher JM, Chen C, Klaassen CD. Hepatic ischemia-reperfusion induces renal heme oxygenase-1 via NF-E2-related factor 2 in rats and mice. Molecular Pharmacology. 71: 817-25. PMID 17151289 DOI: 10.1124/Mol.106.029033  0.88
2007 Slitt AL, Allen K, Morrone J, Aleksunes LM, Chen C, Maher JM, Manautou JE, Cherrington NJ, Klaassen CD. Regulation of transporter expression in mouse liver, kidney, and intestine during extrahepatic cholestasis. Biochimica Et Biophysica Acta. 1768: 637-47. PMID 17141734 DOI: 10.1016/J.Bbamem.2006.10.008  0.88
2007 Buckley DB, Klaassen CD. Tissue- and gender-specific mRNA expression of UDP-glucuronosyltransferases (UGTs) in mice. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 35: 121-7. PMID 17050650 DOI: 10.1124/Dmd.106.012070  0.96
2006 Aleksunes LM, Slitt AL, Maher JM, Dieter MZ, Knight TR, Goedken M, Cherrington NJ, Chan JY, Klaassen CD, Manautou JE. Nuclear factor-E2-related factor 2 expression in liver is critical for induction of NAD(P)H:quinone oxidoreductase 1 during cholestasis. Cell Stress & Chaperones. 11: 356-63. PMID 17278884 DOI: 10.1379/Csc-217.1  0.88
2006 Lu H, Lei X, Klaassen C. Gender differences in renal nuclear receptors and aryl hydrocarbon receptor in 5/6 nephrectomized rats Kidney International. 70: 1920-1928. PMID 16985511 DOI: 10.1038/Sj.Ki.5001880  0.88
2006 Cheng X, Klaassen CD. Regulation of mRNA expression of xenobiotic transporters by the pregnane x receptor in mouse liver, kidney, and intestine. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 34: 1863-7. PMID 16928788 DOI: 10.1124/Dmd.106.010520  1
2006 Tanaka Y, Chen C, Maher JM, Klaassen CD. Kupffer cell-mediated downregulation of hepatic transporter expression in rat hepatic ischemia-reperfusion. Transplantation. 82: 258-66. PMID 16858290 DOI: 10.1097/01.Tp.0000226243.69023.54  0.88
2006 Shelby MK, Klaassen CD. Induction of rat UDP-glucuronosyltransferases in liver and duodenum by microsomal enzyme inducers that activate various transcriptional pathways. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 34: 1772-8. PMID 16855052 DOI: 10.1124/Dmd.106.010397  1
2006 Cheng X, Maher J, Lu H, Klaassen CD. Endocrine regulation of gender-divergent mouse organic anion-transporting polypeptide (Oatp) expression. Molecular Pharmacology. 70: 1291-7. PMID 16807376 DOI: 10.1124/Mol.106.025122  1
2006 Maher JM, Slitt AL, Callaghan TN, Cheng X, Cheung C, Gonzalez FJ, Klaassen CD. Alterations in transporter expression in liver, kidney, and duodenum after targeted disruption of the transcription factor HNF1alpha. Biochemical Pharmacology. 72: 512-22. PMID 16806085 DOI: 10.1016/J.Bcp.2006.03.016  0.88
2006 Nakamoto K, Wang S, Jenison RD, Guo GL, Klaassen CD, Wan YJ, Zhong XB. Linkage disequilibrium blocks, haplotype structure, and htSNPs of human CYP7A1 gene. Bmc Genetics. 7: 29. PMID 16709249 DOI: 10.1186/1471-2156-7-29  0.76
2006 Slitt AL, Cherrington NJ, Fisher CD, Negishi M, Klaassen CD. Induction of genes for metabolism and transport by trans-stilbene oxide in livers of Sprague-Dawley and Wistar-Kyoto rats. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 34: 1190-7. PMID 16621935 DOI: 10.1124/Dmd.105.007542  0.76
2006 Maher JM, Cheng X, Tanaka Y, Scheffer GL, Klaassen CD. Hormonal regulation of renal multidrug resistance-associated proteins 3 and 4 (Mrp3 and Mrp4) in mice. Biochemical Pharmacology. 71: 1470-8. PMID 16529719 DOI: 10.1016/J.Bcp.2006.02.005  0.88
2006 Moffit JS, Aleksunes LM, Maher JM, Scheffer GL, Klaassen CD, Manautou JE. Induction of hepatic transporters multidrug resistance-associated proteins (Mrp) 3 and 4 by clofibrate is regulated by peroxisome proliferator-activated receptor alpha. The Journal of Pharmacology and Experimental Therapeutics. 317: 537-45. PMID 16467456 DOI: 10.1124/Jpet.105.093765  0.88
2006 Leslie EM, Liu J, Klaassen CD, Waalkes MP. Acquired cadmium resistance in metallothionein-I/II(-/-) knockout cells: role of the T-type calcium channel Cacnalpha1G in cadmium uptake. Molecular Pharmacology. 69: 629-39. PMID 16282520 DOI: 10.1124/Mol.105.014241  0.88
2006 Maher JM, Cherrington NJ, Slitt AL, Klaassen CD. Tissue distribution and induction of the rat multidrug resistance-associated proteins 5 and 6. Life Sciences. 78: 2219-25. PMID 16260000 DOI: 10.1016/J.Lfs.2005.09.016  0.88
2005 Dai G, Chou N, He L, Gyamfi MA, Mendy AJ, Slitt AL, Klaassen CD, Wan YJ. Retinoid X receptor alpha Regulates the expression of glutathione s-transferase genes and modulates acetaminophen-glutathione conjugation in mouse liver. Molecular Pharmacology. 68: 1590-6. PMID 16157696 DOI: 10.1124/Mol.105.013680  0.68
2005 Chen C, Slitt AL, Dieter MZ, Tanaka Y, Scheffer GL, Klaassen CD. Up-regulation of Mrp4 expression in kidney of Mrp2-deficient TR- rats. Biochemical Pharmacology. 70: 1088-95. PMID 16099435 DOI: 10.1016/J.Bcp.2005.06.019  1
2005 Cheng X, Maher J, Dieter MZ, Klaassen CD. Regulation of mouse organic anion-transporting polypeptides (Oatps) in liver by prototypical microsomal enzyme inducers that activate distinct transcription factor pathways. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 33: 1276-82. PMID 15919853 DOI: 10.1124/Dmd.105.003988  1
2005 Cheng X, Maher J, Chen C, Klaassen CD. Tissue distribution and ontogeny of mouse organic anion transporting polypeptides (Oatps). Drug Metabolism and Disposition: the Biological Fate of Chemicals. 33: 1062-73. PMID 15843488 DOI: 10.1124/Dmd.105.003640  1
2005 Maher JM, Cheng X, Slitt AL, Dieter MZ, Klaassen CD. Induction of the multidrug resistance-associated protein family of transporters by chemical activators of receptor-mediated pathways in mouse liver. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 33: 956-62. PMID 15833929 DOI: 10.1124/Dmd.105.003798  0.88
2005 Maher JM, Slitt AL, Cherrington NJ, Cheng X, Klaassen CD. Tissue distribution and hepatic and renal ontogeny of the multidrug resistance-associated protein (Mrp) family in mice. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 33: 947-55. PMID 15802388 DOI: 10.1124/Dmd.105.003780  0.88
2005 Tanaka Y, Slitt AL, Leazer TM, Maher JM, Klaassen CD. Tissue distribution and hormonal regulation of the breast cancer resistance protein (Bcrp/Abcg2) in rats and mice. Biochemical and Biophysical Research Communications. 326: 181-7. PMID 15567169 DOI: 10.1016/J.Bbrc.2004.11.012  0.88
2005 Aleksunes LM, Slitt AM, Cherrington NJ, Thibodeau MS, Klaassen CD, Manautou JE. Differential expression of mouse hepatic transporter genes in response to acetaminophen and carbon tetrachloride. Toxicological Sciences : An Official Journal of the Society of Toxicology. 83: 44-52. PMID 15496496 DOI: 10.1093/Toxsci/Kfi013  0.76
2004 Dieter MZ, Maher JM, Cheng X, Klaassen CD. Expression and regulation of the sterol half-transporter genes ABCG5 and ABCG8 in rats. Comparative Biochemistry and Physiology. Toxicology & Pharmacology : Cbp. 139: 209-18. PMID 15683829 DOI: 10.1016/J.Cca.2004.11.002  0.88
2004 Lu H, Chen C, Klaassen C. Tissue distribution of concentrative and equilibrative nucleoside transporters in male and female rats and mice. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 32: 1455-61. PMID 15371301 DOI: 10.1124/Dmd.104.001123  0.36
2004 Li B, Zhong H, Scheuer T, Catterall WA. Functional role of a C-terminal Gbetagamma-binding domain of Ca(v)2.2 channels. Molecular Pharmacology. 66: 761-9. PMID 15322269 DOI: 10.1124/mol.66.3  0.36
2004 Cherrington NJ, Slitt AL, Li N, Klaassen CD. Lipopolysaccharide-mediated regulation of hepatic transporter mRNA levels in rats. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 32: 734-41. PMID 15205389 DOI: 10.1124/Dmd.32.7.734  0.76
2004 Vansell NR, Muppidi JR, Habeebu SM, Klaassen CD. Promotion of thyroid tumors in rats by pregnenolone-16alpha-carbonitrile (PCN) and polychlorinated biphenyl (PCB). Toxicological Sciences : An Official Journal of the Society of Toxicology. 81: 50-9. PMID 15201439 DOI: 10.1093/Toxsci/Kfh197  1
2004 Buist SC, Klaassen CD. Rat and mouse differences in gender-predominant expression of organic anion transporter (Oat1-3; Slc22a6-8) mRNA levels. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 32: 620-5. PMID 15155553 DOI: 10.1124/Dmd.32.6.620  1
2004 Heijne WH, Slitt AL, van Bladeren PJ, Groten JP, Klaassen CD, Stierum RH, van Ommen B. Bromobenzene-induced hepatotoxicity at the transcriptome level. Toxicological Sciences : An Official Journal of the Society of Toxicology. 79: 411-22. PMID 15056800 DOI: 10.1093/Toxsci/Kfh128  0.68
2004 Chen C, Klaassen CD. Rat multidrug resistance protein 4 (Mrp4, Abcc4): molecular cloning, organ distribution, postnatal renal expression, and chemical inducibility. Biochemical and Biophysical Research Communications. 317: 46-53. PMID 15047146 DOI: 10.1016/J.Bbrc.2004.03.014  0.36
2004 Xie Y, Liu J, Liu Y, Klaassen CD, Waalkes MP. Toxicokinetic and genomic analysis of chronic arsenic exposure in multidrug-resistance mdr1a/1b(-/-) double knockout mice. Molecular and Cellular Biochemistry. 255: 11-8. PMID 14971641 DOI: 10.1023/B:Mcbi.0000007256.44450.8C  0.88
2003 Choudhuri S, Cherrington NJ, Li N, Klaassen CD. Constitutive expression of various xenobiotic and endobiotic transporter mRNAs in the choroid plexus of rats. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 31: 1337-45. PMID 14570765 DOI: 10.1124/Dmd.31.11.1337  0.76
2003 Cherrington NJ, Slitt AL, Maher JM, Zhang XX, Zhang J, Huang W, Wan YJ, Moore DD, Klaassen CD. Induction of multidrug resistance protein 3 (mrp3) in vivo is independent of constitutive androstane receptor. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 31: 1315-9. PMID 14570762 DOI: 10.1124/Dmd.31.11.1315  0.88
2003 Slitt AL, Cherrington NJ, Maher JM, Klaassen CD. Induction of multidrug resistance protein 3 in rat liver is associated with altered vectorial excretion of acetaminophen metabolites. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 31: 1176-86. PMID 12920174 DOI: 10.1124/Dmd.31.9.1176  0.88
2003 Chen C, Staudinger JL, Klaassen CD. Nuclear receptor, pregname X receptor, is required for induction of UDP-glucuronosyltranferases in mouse liver by pregnenolone-16 alpha-carbonitrile. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 31: 908-15. PMID 12814968 DOI: 10.1124/Dmd.31.7.908  1
2003 Buist SC, Cherrington NJ, Klaassen CD. Endocrine regulation of rat organic anion transporters. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 31: 559-64. PMID 12695343 DOI: 10.1124/Dmd.31.5.559  1
2003 Hood A, Allen ML, Liu Y, Liu J, Klaassen CD. Induction of T4 UDP-GT activity, serum thyroid stimulating hormone, and thyroid follicular cell proliferation in mice treated with microsomal enzyme inducers Toxicology and Applied Pharmacology. 188: 6-13. PMID 12668117 DOI: 10.1016/S0041-008X(02)00071-6  0.88
2003 Shelby MK, Cherrington NJ, Vansell NR, Klaassen CD. Tissue mRNA expression of the rat UDP-glucuronosyltransferase gene family. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 31: 326-33. PMID 12584160 DOI: 10.1124/Dmd.31.3.326  1
2002 Leazer TM, Liu Y, Klaassen CD. Cadmium absorption and its relationship to divalent metal transporter-1 in the pregnant rat. Toxicology and Applied Pharmacology. 185: 18-24. PMID 12460733 DOI: 10.1006/Taap.2002.9505  0.84
2002 Teuschler L, Klaunig J, Carney E, Chambers J, Conolly R, Gennings C, Giesy J, Hertzberg R, Klaassen C, Kodell R, Paustenbach D, Yang R. Support of science-based decisions concerning the evaluation of the toxicology of mixtures: a new beginning. Regulatory Toxicology and Pharmacology : Rtp. 36: 34-9. PMID 12383716 DOI: 10.1006/Rtph.2002.1570  0.88
2002 Johnson DR, Guo GL, Klaassen CD. Expression of rat Multidrug Resistance Protein 2 (Mrp2) in male and female rats during normal and pregnenolone-16alpha-carbonitrile (PCN)-induced postnatal ontogeny. Toxicology. 178: 209-19. PMID 12167307 DOI: 10.1016/S0300-483X(02)00231-7  0.76
2002 Park JD, Cherrington NJ, Klaassen CD. Intestinal absorption of cadmium is associated with divalent metal transporter 1 in rats. Toxicological Sciences : An Official Journal of the Society of Toxicology. 68: 288-94. PMID 12151624 DOI: 10.1093/Toxsci/68.2.288  0.76
2002 Brady JM, Cherrington NJ, Hartley DP, Buist SC, Li N, Klaassen CD. Tissue distribution and chemical induction of multiple drug resistance genes in rats. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 30: 838-44. PMID 12065443 DOI: 10.1124/Dmd.30.7.838  0.88
2002 Li N, Hartley DP, Cherrington NJ, Klaassen CD. Tissue expression, ontogeny, and inducibility of rat organic anion transporting polypeptide 4. The Journal of Pharmacology and Experimental Therapeutics. 301: 551-60. PMID 11961056 DOI: 10.1124/Jpet.301.2.551  0.76
2002 Liu J, Kadiiska MB, Corton JC, Qu W, Waalkes MP, Mason RP, Liu Y, Klaassen CD. Acute cadmium exposure induces stress-related gene expression in wild-type and metallothionein-I/II-null mice. Free Radical Biology & Medicine. 32: 525-35. PMID 11958953 DOI: 10.1016/S0891-5849(01)00826-7  0.88
2002 Buist SC, Cherrington NJ, Choudhuri S, Hartley DP, Klaassen CD. Gender-specific and developmental influences on the expression of rat organic anion transporters. The Journal of Pharmacology and Experimental Therapeutics. 301: 145-51. PMID 11907168 DOI: 10.1124/Jpet.301.1.145  1
2002 Guo GL, Staudinger J, Ogura K, Klaassen CD. Induction of rat organic anion transporting polypeptide 2 by pregnenolone-16alpha-carbonitrile is via interaction with pregnane X receptor. Molecular Pharmacology. 61: 832-9. PMID 11901222 DOI: 10.1124/Mol.61.4.832  0.76
2002 Guo GL, Johnson DR, Klaassen CD. Postnatal expression and induction by pregnenolone-16alpha-carbonitrile of the organic anion-transporting polypeptide 2 in rat liver. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 30: 283-8. PMID 11854146 DOI: 10.1124/Dmd.30.3.283  0.76
2002 Vansell NR, Klaassen CD. Increase in rat liver UDP-glucuronosyltransferase mRNA by microsomal enzyme inducers that enhance thyroid hormone glucuronidation. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 30: 240-6. PMID 11854140 DOI: 10.1124/Dmd.30.3.240  1
2002 Park JD, Habeebu SS, Klaassen CD. Testicular toxicity of di-(2-ethylhexyl)phthalate in young Sprague-Dawley rats. Toxicology. 171: 105-15. PMID 11836017 DOI: 10.1016/S0300-483X(01)00567-4  0.4
2002 Vansell NR, Klaassen CD. Effect of microsomal enzyme inducers on the biliary excretion of triiodothyronine (T(3)) and its metabolites. Toxicological Sciences : An Official Journal of the Society of Toxicology. 65: 184-91. PMID 11812922 DOI: 10.1093/Toxsci/65.2.184  1
2002 Slitt AL, Cherrington NJ, Hartley DP, Leazer TM, Klaassen CD. Tissue distribution and renal developmental changes in rat organic cation transporter mRNA levels. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 30: 212-9. PMID 11792693 DOI: 10.1124/Dmd.30.2.212  0.76
2002 Guo GL, Choudhuri S, Klaassen CD. Induction profile of rat organic anion transporting polypeptide 2 (oatp2) by prototypical drug-metabolizing enzyme inducers that activate gene expression through ligand-activated transcription factor pathways. The Journal of Pharmacology and Experimental Therapeutics. 300: 206-12. PMID 11752118 DOI: 10.1124/Jpet.300.1.206  0.76
2002 Cherrington NJ, Hartley DP, Li N, Johnson DR, Klaassen CD. Organ distribution of multidrug resistance proteins 1, 2, and 3 (Mrp1, 2, and 3) mRNA and hepatic induction of Mrp3 by constitutive androstane receptor activators in rats. The Journal of Pharmacology and Experimental Therapeutics. 300: 97-104. PMID 11752103 DOI: 10.1124/Jpet.300.1.97  0.76
2002 Liu J, Liu Y, Powell DA, Waalkes MP, Klaassen CD. Multidrug-resistance mdr1a/1b double knockout mice are more sensitive than wild type mice to acute arsenic toxicity, with higher arsenic accumulation in tissues. Toxicology. 170: 55-62. PMID 11750083 DOI: 10.1016/S0300-483X(01)00532-7  0.88
2002 Habeebu SS, Liu Y, Park JD, Klaassen CD. Strain differences in the toxicity of cadmium to trigeminal ganglia in mice. Toxicology and Applied Pharmacology. 177: 200-7. PMID 11749119 DOI: 10.1006/Taap.2001.9311  0.44
2001 Vansell NR, Klaassen CD. Increased biliary excretion of thyroxine by microsomal enzyme inducers. Toxicology and Applied Pharmacology. 176: 187-94. PMID 11714251 DOI: 10.1006/Taap.2001.9278  1
2001 Liu J, Corton C, Dix DJ, Liu Y, Waalkes MP, Klaassen CD. Genetic background but not metallothionein phenotype dictates sensitivity to cadmium-induced testicular injury in mice. Toxicology and Applied Pharmacology. 176: 1-9. PMID 11578143 DOI: 10.1006/Taap.2001.9262  0.4
2001 Liu Y, Liu J, Klaassen CD. Metallothionein-null and wild-type mice show similar cadmium absorption and tissue distribution following oral cadmium administration. Toxicology and Applied Pharmacology. 175: 253-9. PMID 11559024 DOI: 10.1006/Taap.2001.9244  0.4
2001 Takiguchi M, Cherrington NJ, Hartley DP, Klaassen CD, Waalkes MP. Cyproterone acetate induces a cellular tolerance to cadmium in rat liver epithelial cells involving reduced cadmium accumulation. Toxicology. 165: 13-25. PMID 11551428 DOI: 10.1016/S0300-483X(01)00402-4  0.84
2001 Liu J, Chen H, Miller DS, Saavedra JE, Keefer LK, Johnson DR, Klaassen CD, Waalkes MP. Overexpression of glutathione S-transferase II and multidrug resistance transport proteins is associated with acquired tolerance to inorganic arsenic. Molecular Pharmacology. 60: 302-9. PMID 11455017 DOI: 10.1124/Mol.60.2.302  0.88
2001 Rausch-Derra LC, Hartley DP, Meier PJ, Klaassen CD. Differential effects of microsomal enzyme-inducing chemicals on the hepatic expression of rat organic anion transporters, OATP1 and OATP2. Hepatology (Baltimore, Md.). 33: 1469-78. PMID 11391536 DOI: 10.1053/Jhep.2001.25088  0.88
2001 Staudinger JL, Goodwin B, Jones SA, Hawkins-Brown D, MacKenzie KI, LaTour A, Liu Y, Klaassen CD, Brown KK, Reinhard J, Willson TM, Koller BH, Kliewer SA. The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity. Proceedings of the National Academy of Sciences of the United States of America. 98: 3369-74. PMID 11248085 DOI: 10.1073/Pnas.051551698  0.88
2000 Liu Y, Liu J, Habeebu SM, Waalkes MP, Klaassen CD. Metallothionein-I/II null mice are sensitive to chronic oral cadmium-induced nephrotoxicity. Toxicological Sciences : An Official Journal of the Society of Toxicology. 57: 167-76. PMID 10966523 DOI: 10.1093/Toxsci/57.1.167  0.56
2000 Jeong SH, Habeebu SS, Klaassen CD. Cadmium decreases gap junctional intercellular communication in mouse liver. Toxicological Sciences : An Official Journal of the Society of Toxicology. 57: 156-66. PMID 10966522 DOI: 10.1093/Toxsci/57.1.156  0.48
2000 Liu J, Liu Y, Habeebu SM, Waalkes MP, Klaassen CD. Chronic combined exposure to cadmium and arsenic exacerbates nephrotoxicity, particularly in metallothionein-I/II null mice. Toxicology. 147: 157-66. PMID 10924798 DOI: 10.1016/S0300-483X(00)00194-3  0.52
2000 Habeebu SS, Liu J, Liu Y, Klaassen CD. Metallothionein-null mice are more susceptible than wild-type mice to chronic CdCl(2)-induced bone injury. Toxicological Sciences : An Official Journal of the Society of Toxicology. 56: 211-9. PMID 10869470 DOI: 10.1093/Toxsci/56.1.211  0.36
2000 Dunn RT, Klaassen CD. Thyroid hormone modulation of rat sulphotransferase mRNA expression. Xenobiotica; the Fate of Foreign Compounds in Biological Systems. 30: 345-57. PMID 10821164 DOI: 10.1080/004982500237550  0.88
2000 Habeebu SS, Liu J, Liu Y, Klaassen CD. Metallothionein-null mice are more sensitive than wild-type mice to liver injury induced by repeated exposure to cadmium. Toxicological Sciences : An Official Journal of the Society of Toxicology. 55: 223-32. PMID 10788577 DOI: 10.1093/Toxsci/55.1.223  0.36
1999 Rojas P, Klaassen CD. Metallothionein-I and -II knock-out mice are not more sensitive than control mice to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine neurotoxicity. Neuroscience Letters. 273: 113-6. PMID 10505629 DOI: 10.1016/S0304-3940(99)00651-5  0.88
1999 Liu J, Liu Y, Habeebu SS, Klaassen CD. Metallothionein-null mice are highly susceptible to the hematotoxic and immunotoxic effects of chronic CdCl2 exposure. Toxicology and Applied Pharmacology. 159: 98-108. PMID 10495773 DOI: 10.1006/Taap.1999.8718  0.4
1999 Liu Y, Liu J, Habeebu SS, Klaassen CD. Metallothionein protects against the nephrotoxicity produced by chronic CdMT exposure. Toxicological Sciences : An Official Journal of the Society of Toxicology. 50: 221-7. PMID 10478858 DOI: 10.1093/Toxsci/50.2.221  0.52
1999 Dunn RT, Kolaja KL, Klaassen CD. Effect of partial hepatectomy on the expression of seven rat sulphotransferase mRNAs. Xenobiotica; the Fate of Foreign Compounds in Biological Systems. 29: 583-93. PMID 10426557 DOI: 10.1080/004982599238407  0.88
1999 Liu J, Liu Y, Habeebu SS, Klaassen CD. Susceptibility of MT-null mice to chronic CdCl2-induced nephrotoxicity indicates that renal injury is not mediated by the CdMT complex. Toxicological Sciences : An Official Journal of the Society of Toxicology. 46: 197-203. PMID 9928683 DOI: 10.1006/Toxs.1998.2541  0.36
1999 Liu J, Habeebu SS, Liu Y, Klaassen CD. Acute CdMT injection is not a good model to study chronic Cd nephropathy: comparison of chronic CdCl2 and CdMT exposure with acute CdMT injection in rats. Toxicology and Applied Pharmacology. 153: 48-58. PMID 9875299 DOI: 10.1006/Taap.1998.8506  0.44
1999 Liu J, Liu Y, Hartley D, Klaassen CD, Shehin-Johnson SE, Lucas A, Cohen SD. Metallothionein-I/II knockout mice are sensitive to acetaminophen-induced hepatotoxicity. Journal of Pharmacology and Experimental Therapeutics. 289: 580-586. DOI: 10.1007/978-3-0348-8847-9_81  0.88
1998 Habeebu SS, Liu J, Klaassen CD. Cadmium-induced apoptosis in mouse liver. Toxicology and Applied Pharmacology. 149: 203-9. PMID 9571989 DOI: 10.1006/taap.1997.8334  0.4
1998 Klaassen CD, Liu L, Dunn RT. Regulation of sulfotransferase mRNA expression in male and female rats of various ages. Chemico-Biological Interactions. 109: 299-313. PMID 9566754 DOI: 10.1016/S0009-2797(97)00141-5  0.88
1997 Aschner M, Cherian MG, Klaassen CD, Palmiter RD, Erickson JC, Bush AI. Metallothioneins in brain--the role in physiology and pathology. Toxicology and Applied Pharmacology. 142: 229-42. PMID 9070344 DOI: 10.1006/Taap.1996.8054  0.88
1996 Liu L, Klaassen CD. Different mechanism of saturation of acetaminophen sulfate conjugation in mice and rats. Toxicology and Applied Pharmacology. 139: 128-34. PMID 8685895 DOI: 10.1006/Taap.1996.0151  0.36
1996 Liu YP, Liu J, Palmiter RD, Klaassen CD. Metallothionein-I-transgenic mice are not protected from acute cadmium-metallothionein-induced nephrotoxicity. Toxicology and Applied Pharmacology. 137: 307-15. PMID 8661357 DOI: 10.1006/Taap.1996.0085  0.88
1996 Liu J, Liu Y, Michalska AE, Choo KH, Klaassen CD. Distribution and retention of cadmium in metallothionein I and II null mice. Toxicology and Applied Pharmacology. 136: 260-8. PMID 8619234 DOI: 10.1006/Taap.1996.0033  0.52
1996 Zheng H, Liu J, Choo KH, Michalska AE, Klaassen CD. Metallothionein-I and -II knock-out mice are sensitive to cadmium-induced liver mRNA expression of c-jun and p53. Toxicology and Applied Pharmacology. 136: 229-35. PMID 8619230 DOI: 10.1006/Taap.1996.0029  0.44
1996 Choudhuri S, Liu WL, Berman NE, Klaassen CD. Cadmium accumulation and metallothionein expression in brain of mice at different stages of development. Toxicology Letters. 84: 127-33. PMID 8600611 DOI: 10.1016/0378-4274(95)03444-7  0.76
1995 Liu Y, Liu J, Iszard MB, Andrews GK, Palmiter RD, Klaassen CD. Transgenic mice that overexpress metallothionein-I are protected from cadmium lethality and hepatotoxicity. Toxicology and Applied Pharmacology. 135: 222-8. PMID 8545831 DOI: 10.1006/Taap.1995.1227  0.88
1995 Choudhuri S, Kramer KK, Berman NE, Dalton TP, Andrews GK, Klaassen CD. Constitutive expression of metallothionein genes in mouse brain. Toxicology and Applied Pharmacology. 131: 144-54. PMID 7878670 DOI: 10.1006/Taap.1995.1056  0.76
1995 Liu J, Liu Y, Bullock P, Klaassen CD. Suppression of liver cytochrome P450 by alpha-hederin: relevance to hepatoprotection. Toxicology and Applied Pharmacology. 134: 124-31. PMID 7676446 DOI: 10.1006/Taap.1995.1175  0.36
1995 Zheng H, Berman NE, Klaassen CD. Chemical modulation of metallothionein I and III mRNA in mouse brain. Neurochemistry International. 27: 43-58. PMID 7655347 DOI: 10.1016/0197-0186(94)00167-S  0.76
1995 Iszard MB, Liu J, Liu Y, Dalton T, Andrews GK, Palmiter RD, Klaassen CD. Characterization of metallothionein-I-transgenic mice. Toxicology and Applied Pharmacology. 133: 305-12. PMID 7645027 DOI: 10.1006/Taap.1995.1155  0.88
1994 Choudhuri S, McKim JM, Klaassen CD. Induction of metallothionein by superantigenic bacterial exotoxin: probable involvement of the immune system Bba - Molecular Basis of Disease. 1225: 171-179. PMID 8280785 DOI: 10.1016/0925-4439(94)90075-2  0.88
1994 Henry RB, Liu J, Choudhuri S, Klaassen CD. Species variation in hepatic metallothionein. Toxicology Letters. 74: 23-33. PMID 8085268 DOI: 10.1016/0378-4274(94)90071-X  0.88
1994 Liu J, Liu Y, Klaassen CD. Nephrotoxicity of CdCl2 and Cd-metallothionein in cultured rat kidney proximal tubules and LLC-PK1 cells. Toxicology and Applied Pharmacology. 128: 264-70. PMID 7940541 DOI: 10.1006/Taap.1994.1206  0.48
1994 Liu J, Liu Y, Klaassen CD. The effect of Chinese hepatoprotective medicines on experimental liver injury in mice. Journal of Ethnopharmacology. 42: 183-91. PMID 7934088 DOI: 10.1016/0378-8741(94)90084-1  0.4
1994 Klaassen CD, Choudhuri S, McKim JM, Lehman-McKeeman LD, Kershaw WC. In vitro and in vivo studies on the degradation of metallothionein Environmental Health Perspectives. 102: 141-146. PMID 7843089 DOI: 10.1289/Ehp.94102S3141  0.88
1993 Choudhuri S, McKim JM, Klaassen CD. Differential expression of the metallothionein gene in liver and brain of mice and rats Toxicology and Applied Pharmacology. 119: 1-10. PMID 8470112 DOI: 10.1006/Taap.1993.1037  0.88
1993 McKim JM, Naumann S, Hammermeister DE, Hoffman AD, Klaassen CD. In vivo microdialysis sampling of phenol and phenyl glucuronide in the blood of unanesthetized rainbow trout: Implications for toxicokinetic studies Fundamental and Applied Toxicology. 20: 190-198. PMID 8449391 DOI: 10.1006/Faat.1993.1026  0.88
1993 Bauman JW, Liu J, Klaassen CD. Production of metallothionein and heat-shock proteins in response to metals. Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology. 21: 15-22. PMID 8365580 DOI: 10.1006/Faat.1993.1066  0.32
1993 Mckim JM, Naumann S, Hammermeister DE, Hoffman AD, Klaassen CD. In Vivo microdialysis sampling of phenol and phenyl glucuronidein the blood of unanesthetized rainbow trout: Implications for toxicokinetic studies Toxicological Sciences. 20: 190-198. DOI: 10.1093/toxsci/20.2.190  0.88
1993 Kreppel H, Bauman JW, Liu J, Mckim JM, Klaassen CD. Induction of metallothionein by arsenicals in mice Toxicological Sciences. 20: 184-189. DOI: 10.1006/Faat.1993.1025  0.88
1992 Choudhuri S, McKim JM, Klaassen CD. Role of hepatic lysosomes in the degradation of metallothionein Toxicology and Applied Pharmacology. 115: 64-71. PMID 1631896 DOI: 10.1016/0041-008X(92)90368-3  0.88
1992 Bauman JW, McKim JM, Liu J, Klaassen CD. Induction of metallothionein by diethyl maleate Toxicology and Applied Pharmacology. 114: 188-196. PMID 1609410 DOI: 10.1016/0041-008X(92)90068-4  0.88
1992 McKim JM, Liu J, Liu YP, Klaassen CD. Distribution of cadmium chloride and cadmium-metallothionein to liver parenchymal, Kupffer, and endothelial cells: Their relative ability to express metallothionein Toxicology and Applied Pharmacology. 112: 324-330. PMID 1539169 DOI: 10.1016/0041-008X(92)90203-5  0.88
1992 McKim JM, Liu J, Liu YP, Klaassen CD. Induction of metallothionein by cadmium-metallothionein in rat liver: A proposed mechanism Toxicology and Applied Pharmacology. 112: 318-323. PMID 1539168 DOI: 10.1016/0041-008X(92)90202-4  0.88
1992 McKim JM, Choudhuri S, Klaassen CD. In vitro degradation of apo-, zinc-, and cadmium-metallothionein by cathepsins B, C, and D Toxicology and Applied Pharmacology. 116: 117-124. PMID 1529444 DOI: 10.1016/0041-008X(92)90152-I  0.88
1992 Bauman JW, Madhu C, McKim JM, Liu Y, Klaassen CD. Induction of hepatic metallothionein by paraquat Toxicology and Applied Pharmacology. 117: 233-241. PMID 1471156 DOI: 10.1016/0041-008X(92)90242-K  0.88
1992 Liu J, Kershaw WC, Liu YP, Klaassen CD. Cadmium-induced hepatic endothelial cell injury in inbred strains of mice. Toxicology. 75: 51-62. PMID 1455424 DOI: 10.1016/0300-483X(92)90125-X  0.44
1992 Goon D, Klaassen CD. Effects of microsomal enzyme inducers upon UDP-glucuronic acid concentration and UDP-glucuronosyltransferase activity in the rat intestine and liver. Toxicology and Applied Pharmacology. 115: 253-60. PMID 1386480 DOI: 10.1016/0041-008X(92)90330-U  0.36
1991 Liu J, Liu YP, Sendelbach LE, Klaassen CD. Endotoxin induction of hepatic metallothionein is mediated through cytokines. Toxicology and Applied Pharmacology. 109: 235-240. PMID 2068724 DOI: 10.1016/0041-008X(91)90171-A  0.88
1991 Bauman JW, Liu J, Liu YP, Klaassen CD. Increase in metallothionein produced by chemicals that induce oxidative stress. Toxicology and Applied Pharmacology. 110: 347-54. PMID 1891778 DOI: 10.1016/S0041-008X(05)80017-1  0.32
1986 Watkins JB, Klaassen CD. Xenobiotic biotransformation in livestock: comparison to other species commonly used in toxicity testing. Journal of Animal Science. 63: 933-42. PMID 3759720 DOI: 10.2527/Jas1986.633933X  0.88
1985 Dudley RE, Gammal LM, Klaassen CD. Cadmium-induced hepatic and renal injury in chronically exposed rats: Likely role of hepatic cadmium-metallothionein in nephrotoxicity Toxicology and Applied Pharmacology. 77: 414-426. PMID 3975909 DOI: 10.1016/0041-008X(85)90181-4  0.88
1984 Dudley RE, Klaassen CD. Changes in hepatic glutathione concentration modify cadmium-induced hepatotoxicity Toxicology and Applied Pharmacology. 72: 530-538. PMID 6710502 DOI: 10.1016/0041-008X(84)90130-3  0.88
1984 Waalkes MP, Harvey MJ, Klaassen CD. Relative in vitro affinity of hepatic metallothionein for metals. Toxicology Letters. 20: 33-9. PMID 6695394 DOI: 10.1016/0378-4274(84)90179-6  0.88
1984 Dudley RE, Svoboda DJ, Klaassen CD. Time course of cadmium-induced ultrastructural changes in rat liver Toxicology and Applied Pharmacology. 76: 150-160. PMID 6484985 DOI: 10.1016/0041-008X(84)90038-3  0.88
1984 Watkins JB, Siegers CP, Klaassen CD. Effect of diethyl ether on the biliary excretion of acetaminophen. Proceedings of the Society For Experimental Biology and Medicine. Society For Experimental Biology and Medicine (New York, N.Y.). 177: 168-75. PMID 6473352 DOI: 10.3181/00379727-177-41928  0.88
1984 Smith GS, Watkins JB, Thompson TN, Rozman K, Klaassen CD. Oxidative and conjugative metabolism of xenobiotics by livers of cattle, sheep, swine and rats Journal of Animal Science. 58: 386-395. PMID 6423601 DOI: 10.2527/Jas1984.582386X  0.88
1983 Waalkes MP, Watkins JB, Klaassen CD. Minimal role of metallothionein in decreased chelator efficacy for cadmium Toxicology and Applied Pharmacology. 68: 392-398. PMID 6857673 DOI: 10.1016/0041-008X(83)90283-1  0.88
1983 Gregus Z, Watkins JB, Thompson TN, Harvey MJ, Rozman K, Klaassen CD. Hepatic phase I and phase II biotransformations in quail and trout: Comparison to other species commonly used in toxicity testing Toxicology and Applied Pharmacology. 67: 430-441. PMID 6845369 DOI: 10.1016/0041-008X(83)90327-7  0.88
1983 Harvey MJ, Klaassen CD. Interaction of metals and carbon tetrachloride on lipid peroxidation and hepatotoxicity. Toxicology and Applied Pharmacology. 71: 316-22. PMID 6558984 DOI: 10.1016/0041-008X(83)90018-2  0.88
1982 Dudley RE, Svoboda DJ, Klaassen CD. Acute exposure to cadmium causes severe liver injury in rats Toxicology and Applied Pharmacology. 65: 302-313. PMID 7179286 DOI: 10.1016/0041-008X(82)90013-8  0.88
1982 Thompson TN, Watkins JB, Gregus Z, Klaassen CD. Effect of microsomal enzyme inducers on the soluble enzymes of hepatic phase II biotransformation Toxicology and Applied Pharmacology. 66: 400-408. PMID 7167967 DOI: 10.1016/0041-008X(82)90306-4  0.88
1982 Watkins JB, Klaassen CD. Determination of hepatic uridine 5′-diphosphoglucuronic acid concentration by conjugation with diethylstilbestrol Journal of Pharmacological Methods. 7: 145-151. PMID 7098497 DOI: 10.1016/0160-5402(82)90027-4  0.88
1982 Watkins JB, Gregus Z, Thompson TN, Klaassen CD. Induction studies on the functional heterogeneity of rat liver UDP-glucuronosyltransferases Toxicology and Applied Pharmacology. 64: 439-446. PMID 6814015 DOI: 10.1016/0041-008X(82)90240-X  0.88
1982 Elenbaas RM, Ryan JL, Robinson WA, Singsank MJ, Harvey MJ, Klaassen CD. On the disulfiram-like activity of moxalactam. Clinical Pharmacology and Therapeutics. 32: 347-55. PMID 6213349 DOI: 10.1038/Clpt.1982.170  0.88
1981 Watkins JB, Klaassen CD. Choleretic effect of valproic acid in the rat Hepatology. 1: 341-347. PMID 6793496 DOI: 10.1002/Hep.1840010411  0.88
1979 Eaton DL, Klaassen CD. Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin, Kepone, and polybrominated biphenyls on transport systems in isolated rat hepatocytes Toxicology and Applied Pharmacology. 51: 137-144. PMID 93319 DOI: 10.1016/0041-008X(79)90016-4  0.88
1977 Huffman DH, Klaassen CD, Hartman CR. Digoxin in hyperthyroidism. Clinical Pharmacology and Therapeutics. 22: 533-8. PMID 913019 DOI: 10.1002/cpt1977225part1533  0.88
1976 Eaton DL, Klaassen CD. Effects of Acute Administration of Taurocholic and Taurochenodeoxycholic Acid on Biliary Lipid Excretion in the Rat Proceedings of the Society For Experimental Biology and Medicine. 151: 198-202. PMID 1250846 DOI: 10.3181/00379727-151-39173  0.88
1969 Harbison RD, Klaassen CD, Becker BA. Hemodynamics of the isolated perfused liver of hypothyroid and hyperthyroid rats. Proceedings of the Society For Experimental Biology and Medicine. Society For Experimental Biology and Medicine (New York, N.Y.). 132: 96-9. PMID 5344874 DOI: 10.3181/00379727-132-34157  0.88
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