Leszek Ignatowicz - Publications

Affiliations: 
Medical College of Georgia, Augusta, GA, United States 
Area:
Immunology, Molecular Biology

43 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Kuczma MP, Szurek EA, Cebula A, Ngo VL, Pietrzak M, Kraj P, Denning TL, Ignatowicz L. Self and microbiota-derived epitopes induce CD4 T cell anergy and conversion into CD4Foxp3 regulatory cells. Mucosal Immunology. PMID 33139845 DOI: 10.1038/s41385-020-00349-4  0.584
2020 Browning LM, Miller C, Kuczma M, Pietrzak M, Jing Y, Rempala G, Muranski P, Ignatowicz L, Kraj P. Bone Morphogenic Proteins Are Immunoregulatory Cytokines Controlling FOXP3 T Cells. Cell Reports. 33: 108219. PMID 33027660 DOI: 10.1016/j.celrep.2020.108219  0.521
2020 Kuczma MP, Szurek EA, Cebula A, Chassaing B, Jung YJ, Kang SM, Fox JG, Stecher B, Ignatowicz L. Commensal epitopes drive differentiation of colonic T. Science Advances. 6: eaaz3186. PMID 32494613 DOI: 10.1126/sciadv.aaz3186  0.648
2019 Cebula A, Kuczma M, Szurek E, Pietrzak M, Savage N, Elhefnawy WR, Rempala G, Kraj P, Ignatowicz L. Dormant pathogenic CD4 T cells are prevalent in the peripheral repertoire of healthy mice. Nature Communications. 10: 4882. PMID 31653839 DOI: 10.1038/S41467-019-12820-3  0.715
2018 Browning LM, Pietrzak M, Kuczma M, Simms CP, Kurczewska A, Refugia JM, Lowery DJ, Rempala G, Gutkin D, Ignatowicz L, Muranski P, Kraj P. TGF-β-mediated enhancement of T17 cell generation is inhibited by bone morphogenetic protein receptor 1α signaling. Science Signaling. 11. PMID 30154100 DOI: 10.1126/Scisignal.Aar2125  0.505
2018 Wojciech L, Szurek E, Kuczma M, Cebula A, Elhefnawy WR, Pietrzak M, Rempala G, Ignatowicz L. Non-canonicaly recruited TCRαβCD8αα IELs recognize microbial antigens. Scientific Reports. 8: 10848. PMID 30022086 DOI: 10.1038/S41598-018-29073-7  0.579
2017 Kraj P, Ignatowicz L. The mechanisms shaping the repertoire of CD4(+) Foxp3(+) Treg cells. Immunology. PMID 29106696 DOI: 10.1111/imm.12859  0.675
2017 Scirka B, Szurek E, Pietrzak M, Rempala G, Kisielow P, Ignatowicz L, Miazek A. Anti-GITR Antibody Treatment Increases TCR Repertoire Diversity of Regulatory but not Effector T Cells Engaged in the Immune Response Against B16 Melanoma. Archivum Immunologiae Et Therapiae Experimentalis. PMID 28638937 DOI: 10.1007/S00005-017-0479-1  0.483
2015 Szurek E, Cebula A, Wojciech L, Pietrzak M, Rempala G, Kisielow P, Ignatowicz L. Differences in Expression Level of Helios and Neuropilin-1 Do Not Distinguish Thymus-Derived from Extrathymically-Induced CD4+Foxp3+ Regulatory T Cells. Plos One. 10: e0141161. PMID 26495986 DOI: 10.1371/Journal.Pone.0141161  0.674
2015 Kuczma M, Wang CY, Ignatowicz L, Gourdie R, Kraj P. Altered connexin 43 expression underlies age-dependent decrease of regulatory T cell suppressor function in nonobese diabetic mice. Journal of Immunology (Baltimore, Md. : 1950). 194: 5261-71. PMID 25911751 DOI: 10.4049/Jimmunol.1400887  0.633
2015 Wojciech L, Ignatowicz L. Tregs strip dendritic cells of CD70 to regulate Th1 differentiation. The Embo Journal. 34: 1290-2. PMID 25870232 DOI: 10.15252/Embj.201591547  0.664
2014 Wojciech L, Ignatowicz A, Seweryn M, Rempala G, Pabla SS, McIndoe RA, Kisielow P, Ignatowicz L. The same self-peptide selects conventional and regulatory CD4⁺ T cells with identical antigen receptors. Nature Communications. 5: 5061. PMID 25270305 DOI: 10.1038/Ncomms6061  0.718
2014 Goto Y, Panea C, Nakato G, Cebula A, Lee C, Diez MG, Laufer TM, Ignatowicz L, Ivanov II. Segmented filamentous bacteria antigens presented by intestinal dendritic cells drive mucosal Th17 cell differentiation. Immunity. 40: 594-607. PMID 24684957 DOI: 10.1016/J.Immuni.2014.03.005  0.497
2013 Cebula A, Seweryn M, Rempala GA, Pabla SS, McIndoe RA, Denning TL, Bry L, Kraj P, Kisielow P, Ignatowicz L. Thymus-derived regulatory T cells contribute to tolerance to commensal microbiota. Nature. 497: 258-62. PMID 23624374 DOI: 10.1038/Nature12079  0.708
2013 Greene J, Birtwistle MR, Ignatowicz L, Rempala GA. Bayesian multivariate Poisson abundance models for T-cell receptor data. Journal of Theoretical Biology. 326: 1-10. PMID 23467198 DOI: 10.1016/J.Jtbi.2013.02.009  0.491
2012 Sonne S, Shekhawat PS, Matern D, Ganapathy V, Ignatowicz L. Carnitine deficiency in OCTN2-/- newborn mice leads to a severe gut and immune phenotype with widespread atrophy, apoptosis and a pro-inflammatory response. Plos One. 7: e47729. PMID 23112839 DOI: 10.1371/Journal.Pone.0047729  0.449
2011 Vanvalkenburgh J, Albu DI, Bapanpally C, Casanova S, Califano D, Jones DM, Ignatowicz L, Kawamoto S, Fagarasan S, Jenkins NA, Copeland NG, Liu P, Avram D. Critical role of Bcl11b in suppressor function of T regulatory cells and prevention of inflammatory bowel disease. The Journal of Experimental Medicine. 208: 2069-81. PMID 21875956 DOI: 10.1084/Jem.20102683  0.693
2011 Singh N, Pacholczyk R, Iwashima M, Ignatowicz L. Generation of T cell hybridomas from naturally occurring FoxP3+ regulatory T cells. Methods in Molecular Biology (Clifton, N.J.). 707: 39-44. PMID 21287327 DOI: 10.1007/978-1-61737-979-6_3  0.609
2011 Rempala GA, Seweryn M, Ignatowicz L. Model for comparative analysis of antigen receptor repertoires. Journal of Theoretical Biology. 269: 1-15. PMID 20955715 DOI: 10.1016/J.Jtbi.2010.10.001  0.354
2010 Daniely D, Kern J, Cebula A, Ignatowicz L. Diversity of TCRs on natural Foxp3+ T cells in mice lacking Aire expression. Journal of Immunology (Baltimore, Md. : 1950). 184: 6865-73. PMID 20483761 DOI: 10.4049/Jimmunol.0903609  0.636
2009 Kuczma M, Podolsky R, Garge N, Daniely D, Pacholczyk R, Ignatowicz L, Kraj P. Foxp3-deficient regulatory T cells do not revert into conventional effector CD4+ T cells but constitute a unique cell subset. Journal of Immunology (Baltimore, Md. : 1950). 183: 3731-41. PMID 19710455 DOI: 10.4049/Jimmunol.0800601  0.644
2007 Pacholczyk R, Kern J, Singh N, Iwashima M, Kraj P, Ignatowicz L. Nonself-antigens are the cognate specificities of Foxp3+ regulatory T cells. Immunity. 27: 493-504. PMID 17869133 DOI: 10.1016/J.Immuni.2007.07.019  0.704
2006 Pacholczyk R, Ignatowicz H, Kraj P, Ignatowicz L. Origin and T cell receptor diversity of Foxp3+CD4+CD25+ T cells. Immunity. 25: 249-59. PMID 16879995 DOI: 10.1016/J.Immuni.2006.05.016  0.755
2006 Nowak I, Pajtasz-Piasecka E, Chmielowski B, Ignatowicz L, Kuśnierczyk P. The specific T-cell response to antigenic peptides is influenced by bystander peptides. Cellular & Molecular Biology Letters. 11: 70-9. PMID 16847750 DOI: 10.2478/S11658-006-0007-5  0.466
2003 Uz-Zaman T, Ignatowicz L, Sarkar NH. Mouse mammary tumor viruses expressed by RIII/Sa mice with a high incidence of mammary tumors interact with the V beta-2- and V beta-8-specific T cells during viral infection. Virology. 314: 294-304. PMID 14517082 DOI: 10.1016/S0042-6822(03)00429-X  0.508
2003 Stephens GL, Ignatowicz L. Decreasing the threshold for thymocyte activation biases CD4+ T cells toward a regulatory (CD4+CD25+) lineage European Journal of Immunology. 33: 1282-1291. PMID 12731053 DOI: 10.1002/Eji.200323927  0.821
2003 Stephens GL, Ashwell JD, Ignatowicz L. Mutually antagonistic signals regulate selection of the T cell repertoire International Immunology. 15: 623-632. PMID 12697662 DOI: 10.1093/Intimm/Dxg060  0.813
2003 Thayer WP, Dao CT, Ignatowicz L, Jensen PE. A novel single chain I-A(b) molecule can stimulate and stain antigen-specific T cells. Molecular Immunology. 39: 861-70. PMID 12686502 DOI: 10.1016/S0161-5890(03)00010-5  0.441
2002 Chmielowski B, Pacholczyk R, Kraj P, Kisielow P, Ignatowicz L. Presentation of antagonist peptides to naive CD4+ T cells abrogates spatial reorganization of class II MHC peptide complexes on the surface of dendritic cells. Proceedings of the National Academy of Sciences of the United States of America. 99: 15012-7. PMID 12411579 DOI: 10.1073/Pnas.222463499  0.593
2002 Sullivan BA, Kraj P, Weber DA, Ignatowicz L, Jensen PE. Positive selection of a Qa-1-restricted T cell receptor with specificity for insulin. Immunity. 17: 95-105. PMID 12150895 DOI: 10.1016/S1074-7613(02)00343-6  0.666
2002 Pacholczyk R, Kraj P, Ignatowicz L. Peptide specificity of thymic selection of CD4+CD25+ T cells. Journal of Immunology (Baltimore, Md. : 1950). 168: 613-20. PMID 11777953 DOI: 10.4049/Jimmunol.168.2.613  0.647
2001 Kraj P, Pacholczyk R, Ignatowicz H, Kisielow P, Jensen P, Ignatowicz L. Positive Selection of Cd4+ T Cells Is Induced in Vivo by Agonist and Inhibited by Antagonist Peptides Journal of Experimental Medicine. 194: 407-416. PMID 11514598 DOI: 10.1084/Jem.194.4.407  0.634
2001 Pacholczyk R, Kraj P, Ignatowicz L. An Incremental Increase in the Complexity of Peptides Bound to Class II MHC Changes the Diversity of Positively Selected αβ TCRs Journal of Immunology. 166: 2357-2363. PMID 11160293 DOI: 10.4049/Jimmunol.166.4.2357  0.39
2001 Kraj P, Pacholczyk R, Ignatowicz L. αβTCRs Differ in the Degree of Their Specificity for the Positively Selecting MHC/Peptide Ligand Journal of Immunology. 166: 2251-2259. PMID 11160279 DOI: 10.4049/Jimmunol.166.4.2251  0.45
2000 Gaszewska-Mastalarz A, Muranski P, Chmielowski B, Kraj P, Ignatowicz L. Altered Selection of CD4+ T Cells by Class II MHC Bound with Dominant and Low Abundance Self-Peptides Journal of Immunology. 165: 6099-6106. PMID 11086042 DOI: 10.4049/Jimmunol.165.11.6099  0.641
2000 Kovalik JP, Singh N, Mendiratta SK, Martin WD, Ignatowicz L, Kaer LV. The Alloreactive and Self-Restricted CD4+ T Cell Response Directed Against a Single MHC Class II/Peptide Combination Journal of Immunology. 165: 1285-1293. PMID 10903728 DOI: 10.4049/Jimmunol.165.3.1285  0.62
2000 Muranski P, Chmielowski B, Ignatowicz L. Mature CD4+ T Cells Perceive a Positively Selecting Class II MHC/Peptide Complex in the Periphery Journal of Immunology. 164: 3087-3094. PMID 10706698 DOI: 10.4049/Jimmunol.164.6.3087  0.676
2000 Chmielowski B, Muranski P, Kisielow P, Ignatowicz L. On the role of high- and low-abundance class II MHC–peptide complexes in the thymic positive selection of CD4+ T cells International Immunology. 12: 67-72. PMID 10607751 DOI: 10.1093/Intimm/12.1.67  0.561
1997 Ignatowicz L, Rees W, Pacholczyk R, Ignatowicz H, Kushnir E, Kappler J, Marrack P. T cells can be activated by peptides that are unrelated in sequence to their selecting peptide. Immunity. 7: 179-86. PMID 9285403 DOI: 10.1016/S1074-7613(00)80521-X  0.509
1996 Ignatowicz L, Kappler J, Marrack P. The repertoire of T cells shaped by a single MHC/peptide ligand. Cell. 84: 521-9. PMID 8598039 DOI: 10.1016/S0092-8674(00)81028-4  0.499
1993 Scherer MT, Ignatowicz L, Winslow GM, Kappler JW, Marrack P. Superantigens: Bacterial and viral proteins that manipulate the immune system Annual Review of Cell Biology. 9: 101-128. PMID 7506550 DOI: 10.1146/Annurev.Cb.09.110193.000533  0.335
1993 Marrack P, McCormack J, Callahan J, Ignatowicz L, Koppler J. T Cell Tolerance Chest. 103: 76S-78S. DOI: 10.1378/Chest.103.2_Supplement.76S  0.595
1991 Swat W, Ignatowicz L, von Boehmer H, Kisielow P. Clonal deletion of immature CD4+8+ thymocytes in suspension culture by extrathymic antigen-presenting cells. Nature. 351: 150-3. PMID 1903182 DOI: 10.1038/351150a0  0.568
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