| Year |
Citation |
Score |
| 2024 |
Atanasova KR, Perkins CM, Ratnayake R, Jiang J, Chen QY, Schmittgen TD, Luesch H. Epigenetic small-molecule screen for inhibition and reversal of acinar ductal metaplasia in mouse pancreatic organoids. Frontiers in Pharmacology. 15: 1335246. PMID 38510657 DOI: 10.3389/fphar.2024.1335246 |
0.57 |
|
| 2024 |
Kallifidas D, Dhakal D, Chen M, Chen QY, Kokkaliari S, Colon Rosa NA, Ratnayake R, Bruner SD, Paul VJ, Ding Y, Luesch H. Biosynthesis of Dolastatin 10 in Marine Cyanobacteria, a Prototype for Multiple Approved Cancer Drugs. Organic Letters. PMID 38330916 DOI: 10.1021/acs.orglett.3c04083 |
0.521 |
|
| 2023 |
Tang Q, Ratnayake R, Seabra G, Jiang Z, Fang R, Cui L, Ding Y, Kahveci T, Bian J, Li C, Luesch H, Li Y. Morphological Profiling for Drug Discovery in the Era of Deep Learning. Arxiv. PMID 38168460 |
0.476 |
|
| 2023 |
Atanasova KR, Perkins CM, Ratnayake R, Jiang J, Chen QY, Schmittgen TD, Luesch H. Epigenetic Small-Molecule Screen for Inhibition and Reversal of Acinar Ductal Metaplasia in Mouse Pancreatic Organoids. Biorxiv : the Preprint Server For Biology. PMID 38077007 DOI: 10.1101/2023.11.27.567685 |
0.718 |
|
| 2023 |
Al-Awadhi FH, Simon EF, Liu N, Ratnayake R, Paul VJ, Luesch H. Discovery and Anti-Inflammatory Activity of a Cyanobacterial Fatty Acid Targeting the Keap1/Nrf2 Pathway. Marine Drugs. 21. PMID 37999377 DOI: 10.3390/md21110553 |
0.797 |
|
| 2023 |
Luo D, Ratnayake R, Atanasova KR, Paul VJ, Luesch H. Targeted and Functional Genomics Approaches to the Mechanism of Action of Lagunamide D, a Mitochondrial Cytotoxin from Marine Cyanobacteria. Biochemical Pharmacology. 115608. PMID 37201874 DOI: 10.1016/j.bcp.2023.115608 |
0.777 |
|
| 2022 |
da Silva L, Jiang J, Perkins C, Atanasova KR, Bray JK, Bulut G, Azevedo-Pouly A, Campbell-Thompson M, Yang X, Hakimjavadi H, Chamala S, Ratnayake R, Gharaibeh RZ, Li C, Luesch H, et al. Pharmacological inhibition and reversal of pancreatic acinar ductal metaplasia. Cell Death Discovery. 8: 378. PMID 36055991 DOI: 10.1038/s41420-022-01165-4 |
0.545 |
|
| 2022 |
Pohl MO, Martin-Sancho L, Ratnayake R, White KM, Riva L, Chen QY, Lieber G, Busnadiego I, Yin X, Lin S, Pu Y, Pache L, Rosales R, Déjosez M, Qin Y, et al. Sec61 Inhibitor Apratoxin S4 Potently Inhibits SARS-CoV-2 and Exhibits Broad-Spectrum Antiviral Activity. Acs Infectious Diseases. PMID 35766385 DOI: 10.1021/acsinfecdis.2c00008 |
0.727 |
|
| 2022 |
Atanasova KR, Chakraborty S, Ratnayake R, Khare KD, Luesch H, Lele TP. An epigenetic small molecule screen to target abnormal nuclear morphology in human cells. Molecular Biology of the Cell. mbcE21100528. PMID 35323046 DOI: 10.1091/mbc.E21-10-0528 |
0.579 |
|
| 2022 |
Gunasekera SP, Kokkaliari S, Ratnayake R, Sauvage T, Dos Santos LAH, Luesch H, Paul VJ. Anti-Inflammatory Dysidazirine Carboxylic Acid from the Marine Cyanobacterium sp. Collected from the Reefs of Fort Lauderdale, Florida. Molecules (Basel, Switzerland). 27. PMID 35268819 DOI: 10.3390/molecules27051717 |
0.571 |
|
| 2021 |
Cai W, Ratnayake R, Wang M, Chen QY, Raisch KP, Dang LH, Law BK, Luesch H. Inhibition of cotranslational translocation by apratoxin S4: Effects on oncogenic receptor tyrosine kinases and the fate of transmembrane proteins produced in the cytoplasm. Current Research in Pharmacology and Drug Discovery. 2: 100053. PMID 34909679 DOI: 10.1016/j.crphar.2021.100053 |
0.787 |
|
| 2021 |
Matthew S, Chen QY, Ratnayake R, Fermaintt CS, Lucena-Agell D, Bonato F, Prota AE, Lim ST, Wang X, Díaz JF, Risinger AL, Paul VJ, Oliva MÁ, Luesch H. Gatorbulin-1, a distinct cyclodepsipeptide chemotype, targets a seventh tubulin pharmacological site. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 33619102 DOI: 10.1073/pnas.2021847118 |
0.784 |
|
| 2021 |
Grenning AJ, Emmetiere F, Ratnayake R, Schares HAM, Jones KFM, Bevan-Smith E, Luesch H, Harki DA. Function-oriented and modular (+/-)-cis-pseudoguaianolide synthesis: Discovery of new Nrf2 Activators and NF-κB Inhibitors. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 33502811 DOI: 10.1002/chem.202100038 |
0.543 |
|
| 2020 |
Lizarme-Salas Y, Ariawan AD, Ratnayake R, Luesch H, Finch A, Hunter L. Vicinal difluorination as a C=C surrogate: an analog of piperine with enhanced solubility, photostability, and acetylcholinesterase inhibitory activity. Beilstein Journal of Organic Chemistry. 16: 2663-2670. PMID 33178356 DOI: 10.3762/bjoc.16.216 |
0.555 |
|
| 2020 |
Jiang G, Zhang P, Ratnayake R, Yang G, Zhang Y, Zuo R, Powell M, Huguet-Tapia JC, Abboud KA, Dang LH, Teplitski M, Paul V, Xiao R, Zaman KAU, Hu Z, et al. Fungal epithiodiketopiperazines carrying α,β-polysulfide bridges from Penecillium steckii YE, and their chemical interconversion. Chembiochem : a European Journal of Chemical Biology. PMID 32816319 DOI: 10.1002/Cbic.202000403 |
0.611 |
|
| 2020 |
Paciaroni NG, Norwood VM, Ratnayake R, Luesch H, Huigens RW. Yohimbine as a Starting Point to Access Diverse Natural Product-Like Agents with Re-programmed Activities against Cancer-Relevant GPCR Targets. Bioorganic & Medicinal Chemistry. 28: 115546. PMID 32616180 DOI: 10.1016/J.Bmc.2020.115546 |
0.626 |
|
| 2020 |
Al-Awadhi FH, Salvador-Reyes LA, Elsadek LA, Ratnayake R, Chen QY, Luesch H. Largazole is a Brain-Penetrant Class I HDAC Inhibitor with Extended Applicability to Glioblastoma and CNS Diseases. Acs Chemical Neuroscience. PMID 32559056 DOI: 10.1021/Acschemneuro.0C00093 |
0.758 |
|
| 2020 |
Tamashunas AC, Tocco VJ, Matthews J, Zhang Q, Atanasova KR, Paschall L, Pathak S, Ratnayake R, Stephens AD, Luesch H, Licht JD, Lele TP. High-throughput gene screen reveals modulators of nuclear shape. Molecular Biology of the Cell. mbcE19090520. PMID 32320319 DOI: 10.1091/Mbc.E19-09-0520 |
0.723 |
|
| 2020 |
Ratnayake R, Gunasekera SP, Ma JJ, Dang LH, Carney T, Paul VJ, Luesch H. Dolastatin 15 from a Marine Cyanobacterium Suppresses HIF-1α Mediated Cancer Cell Viability and Vascularization. Chembiochem : a European Journal of Chemical Biology. PMID 32237262 DOI: 10.1002/Cbic.202000180 |
0.619 |
|
| 2020 |
Norwood VM, Brice-Tutt A, Eans SO, Stacy H, Shi G, Ratnayake R, Rocca JR, Abboud KA, Li C, Luesch H, McLaughlin JP, Huigens Iii RW. Preventing Morphine Seeking Behavior through the Re-engineering of Vincamine's Biological Activity. Journal of Medicinal Chemistry. PMID 31913038 DOI: 10.1021/Acs.Jmedchem.9B01924 |
0.56 |
|
| 2020 |
Norwood V, Brice-Tutt AC, Eans SO, Stacy HM, Shi G, Ratnayake R, Rocca JR, Abboud KA, Li C, Luesch H, McLaughlin JP, Huigens RW. Preventing Morphine-SeekingBehavior through the Re-Engineeringof Vincamine’s Biological Activity Journal of Medicinal Chemistry. DOI: 10.1021/Acs.Jmedchem.9B01924.S001 |
0.561 |
|
| 2020 |
Liu Q, Liu L, Ratnayake R, Luesch H, Guo Y, Ye T. Nine‐Step Total Synthesis and Biological Evaluation of Rhizonin A Chinese Journal of Chemistry. DOI: 10.1002/Cjoc.202000222 |
0.534 |
|
| 2019 |
Liu L, Guo Y, Liu Q, Ratnayake R, Luesch H, Ye T. Total Synthesis of Endolides A and B. Synlett : Accounts and Rapid Communications in Synthetic Organic Chemistry. 30: 2279-2284. PMID 34163101 DOI: 10.1055/s-0037-1610736 |
0.487 |
|
| 2019 |
Dekan Z, Sianati S, Yousuf A, Sutcliffe KJ, Gillis A, Mallet C, Singh P, Jin AH, Wang AM, Mohammadi SA, Stewart M, Ratnayake R, Fontaine F, Lacey E, Piggott AM, et al. A tetrapeptide class of biased analgesics from an Australian fungus targets the µ-opioid receptor. Proceedings of the National Academy of Sciences of the United States of America. PMID 31611414 DOI: 10.1073/Pnas.1908662116 |
0.666 |
|
| 2019 |
Bousquet MS, Ratnayake R, Pope JL, Chen QY, Zhu F, Chen S, Carney TJ, Gharaibeh RZ, Jobin C, Paul VJ, Luesch H. Seaweed natural products modify the host inflammatory response via Nrf2 signaling and alter colon microbiota composition and gene expression. Free Radical Biology & Medicine. PMID 31536771 DOI: 10.1016/J.Freeradbiomed.2019.09.013 |
0.743 |
|
| 2019 |
Liu L, Guo Y, Liu Q, Ratnayake R, Luesch H, Ye T. Total Synthesis of Endolides A and B Synlett. 30: 2279-2284. DOI: 10.1055/S-0037-1610736 |
0.538 |
|
| 2018 |
Yan JL, Cheng Y, Chen J, Ratnayake R, Dang LH, Luesch H, Guo Y, Ye T. Total Synthesis of Asperphenins A and B. Organic Letters. PMID 30232896 DOI: 10.1021/Acs.Orglett.8B02652 |
0.529 |
|
| 2018 |
Cai W, Ratnayake R, Gerber MH, Chen QY, Yu Y, Derendorf H, Trevino JG, Luesch H. Development of apratoxin S10 (Apra S10) as an anti-pancreatic cancer agent and its preliminary evaluation in an orthotopic patient-derived xenograft (PDX) model. Investigational New Drugs. PMID 30073464 DOI: 10.1007/S10637-018-0647-0 |
0.785 |
|
| 2017 |
Cai W, Salvador-Reyes LA, Zhang W, Chen QY, Matthew S, Ratnayake R, Seo SJ, Dolles S, Gibson DJ, Paul VJ, Luesch H. Apratyramide, a Marine-Derived Peptidic Stimulator of VEGF-A and Other Growth Factors with Potential Application in Wound Healing. Acs Chemical Biology. PMID 29205032 DOI: 10.1021/Acschembio.7B00827 |
0.762 |
|
| 2017 |
Kim B, Ratnayake R, Lee H, Shi G, Zeller SL, Li C, Luesch H, Hong J. Synthesis and biological evaluation of largazole zinc-binding group analogs. Bioorganic & Medicinal Chemistry. PMID 28416100 DOI: 10.1016/J.Bmc.2017.03.071 |
0.594 |
|
| 2017 |
Paciaroni NG, Ratnayake R, Matthews JH, Norwood VM, Arnold AC, Dang LH, Luesch H, Huigens RW. Back Cover: A Tryptoline Ring‐Distortion Strategy Leads to Complex and Diverse Biologically Active Molecules from the Indole Alkaloid Yohimbine (Chem. Eur. J. 18/2017) Chemistry: a European Journal. 23: 4463-4463. DOI: 10.1002/Chem.201605731 |
0.717 |
|
| 2016 |
Paciaroni N, Ratnayake R, Matthews J, Norwood V, Arnold A, Dang L, Luesch H, Huigens Iii RW. A Tryptoline Ring Distortion Strategy Leads to Complex and Diverse Biologically Active Molecules from the Indole Alkaloid Yohimbine. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 27900785 DOI: 10.1002/Chem.201604795 |
0.761 |
|
| 2016 |
Gunasekera SP, Imperial L, Garst C, Ratnayake R, Dang LH, Paul VJ, Luesch H. Caldoramide, a Modified Pentapeptide from the Marine Cyanobacterium Caldora penicillata. Journal of Natural Products. PMID 27380142 DOI: 10.1021/Acs.Jnatprod.6B00203 |
0.773 |
|
| 2016 |
Al-Awadhi FH, Ratnayake R, Paul VJ, Luesch H. Tasiamide F, a potent inhibitor of cathepsins D and E from a marine cyanobacterium. Bioorganic & Medicinal Chemistry. PMID 27211244 DOI: 10.1016/J.Bmc.2016.04.062 |
0.78 |
|
| 2016 |
Gunasekera SP, Li Y, Ratnayake R, Luo D, Lo J, Reibenspies JH, Xu Z, Clare-Salzler MJ, Ye T, Paul VJ, Luesch H. Discovery, Total Synthesis and Key Structural Elements for the Immunosuppressive Activity of Cocosolide, a Symmetrical Glycosylated Macrolide Dimer from Marine Cyanobacteria. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 27139508 DOI: 10.1002/Chem.201600674 |
0.792 |
|
| 2016 |
Caropreso V, Darvishi E, Turbyville TJ, Ratnayake R, Grohar PJ, McMahon JB, Woldemichael G. Englerin A inhibits EWS-FLI1 DNA Binding in Ewings Sarcoma Cells. The Journal of Biological Chemistry. PMID 26961871 DOI: 10.1074/Jbc.M115.701375 |
0.714 |
|
| 2016 |
Bousquet MS, Ma JJ, Ratnayake R, Havre PA, Yao J, Dang NH, Paul VJ, Carney TJ, Dang LH, Luesch H. Multidimensional Screening Platform for Simultaneously Targeting Oncogenic KRAS and Hypoxia-Inducible Factors Pathways in Colorectal Cancer. Acs Chemical Biology. PMID 26938486 DOI: 10.1021/Acschembio.5B00860 |
0.754 |
|
| 2016 |
Vijayasarathy S, Prasad P, Fremlin LJ, Ratnayake R, Salim AA, Khalil Z, Capon RJ. C3 and 2D C3 Marfey's Methods for Amino Acid Analysis in Natural Products. Journal of Natural Products. PMID 26863178 DOI: 10.1021/Acs.Jnatprod.5B01125 |
0.486 |
|
| 2015 |
Cai W, Salvador-Reyes L, Zhang W, Matthew S, Ratnayake R, Paul V, Dang L, Luesch H. Discovery, synthesis, and biological evaluation of apratyramide, a marine-derived transcriptional stimulator of VEGF-A Planta Medica. 81. DOI: 10.1055/S-0035-1556169 |
0.758 |
|
| 2014 |
Kwan JC, Liu Y, Ratnayake R, Hatano R, Kuribara A, Morimoto C, Ohnuma K, Paul VJ, Ye T, Luesch H. Grassypeptolides as natural inhibitors of dipeptidyl peptidase 8 and T-cell activation. Chembiochem : a European Journal of Chemical Biology. 15: 799-804. PMID 24591193 DOI: 10.1002/Cbic.201300762 |
0.788 |
|
| 2013 |
Ratnayake R, Liu Y, Paul VJ, Luesch H. Cultivated sea lettuce is a multiorgan protector from oxidative and inflammatory stress by enhancing the endogenous antioxidant defense system. Cancer Prevention Research (Philadelphia, Pa.). 6: 989-99. PMID 24005795 DOI: 10.1158/1940-6207.Capr-13-0014 |
0.693 |
|
| 2013 |
Sourbier C, Scroggins BT, Ratnayake R, Prince TL, Lee S, Lee MJ, Nagy PL, Lee YH, Trepel JB, Beutler JA, Linehan WM, Neckers L. Englerin A stimulates PKCθ to inhibit insulin signaling and to simultaneously activate HSF1: pharmacologically induced synthetic lethality. Cancer Cell. 23: 228-37. PMID 23352416 DOI: 10.1016/J.Ccr.2012.12.007 |
0.554 |
|
| 2012 |
Diyabalanage T, Ratnayake R, Bokesch HR, Ransom TT, Henrich CJ, Beutler JA, McMahon JB, Gustafson KR. Flabelliferins A and B, sesterterpenoids from the South Pacific sponge Carteriospongia flabellifera. Journal of Natural Products. 75: 1490-4. PMID 22834941 DOI: 10.1021/Np3003518 |
0.55 |
|
| 2012 |
Akee RK, Ransom T, Ratnayake R, McMahon JB, Beutler JA. Chlorinated englerins with selective inhibition of renal cancer cell growth. Journal of Natural Products. 75: 459-63. PMID 22280462 DOI: 10.1021/Np200905U |
0.595 |
|
| 2011 |
Popplewell WL, Ratnayake R, Wilson JA, Beutler JA, Colburn NH, Henrich CJ, McMahon JB, McKee TC. Grassypeptolides F and G, cyanobacterial peptides from Lyngbya majuscula. Journal of Natural Products. 74: 1686-91. PMID 21806011 DOI: 10.1021/Np2005083 |
0.547 |
|
| 2011 |
Diyabalanage T, Ratnayake R, Wilson JA, Henrich CJ, Beutler JA, Colburn NH, McMahon JB, Gustafson KR. Nothospondin, a new AP-1 inhibitory quassinoid from the Cameroonian plant Nothospondias staudtii. Bioorganic & Medicinal Chemistry Letters. 21: 4397-9. PMID 21733691 DOI: 10.1016/J.Bmcl.2011.06.044 |
0.603 |
|
| 2011 |
Devkota KP, Ratnayake R, Colburn NH, Wilson JA, Henrich CJ, McMahon JB, Beutler JA. Inhibitors of the oncogenic transcription factor AP-1 from Podocarpus latifolius. Journal of Natural Products. 74: 374-7. PMID 21306129 DOI: 10.1021/Np100736Y |
0.722 |
|
| 2011 |
Versiani MA, Diyabalanage T, Ratnayake R, Henrich CJ, Bates SE, McMahon JB, Gustafson KR. Flavonoids from eight tropical plant species that inhibit the multidrug resistance transporter ABCG2. Journal of Natural Products. 74: 262-6. PMID 21275386 DOI: 10.1021/Np100797Y |
0.36 |
|
| 2011 |
Sourbier C, Ratnayake R, Scroggins B, Lee M, Lee S, Trepel J, Beutler J, Neckers L, Linehan WM. Abstract 959: Targeting renal cell carcinoma with englerin A Cancer Research. 71: 959-959. DOI: 10.1158/1538-7445.Am2011-959 |
0.602 |
|
| 2010 |
Kwan JC, Ratnayake R, Abboud KA, Paul VJ, Luesch H. Grassypeptolides A-C, cytotoxic bis-thiazoline containing marine cyclodepsipeptides. The Journal of Organic Chemistry. 75: 8012-23. PMID 21047144 DOI: 10.1021/Jo1013564 |
0.744 |
|
| 2010 |
Matthew S, Ratnayake R, Becerro MA, Ritson-Williams R, Paul VJ, Luesch H. Intramolecular modulation of serine protease inhibitor activity in a marine cyanobacterium with antifeedant properties. Marine Drugs. 8: 1803-16. PMID 20631871 DOI: 10.3390/Md8061803 |
0.747 |
|
| 2009 |
Ratnayake R, Covell D, Ransom TT, Gustafson KR, Beutler JA. Englerin A, a selective inhibitor of renal cancer cell growth, from Phyllanthus engleri. Organic Letters. 11: 57-60. PMID 19061394 DOI: 10.1021/Ol802339W |
0.582 |
|
| 2008 |
Ratnayake R, Fremlin LJ, Lacey E, Gill JH, Capon RJ. Acremolides A-D, lipodepsipeptides from an Australian marine-derived fungus, Acremonium sp. Journal of Natural Products. 71: 403-8. PMID 18288804 DOI: 10.1021/Np070589G |
0.52 |
|
| 2007 |
Capon RJ, Stewart M, Ratnayake R, Lacey E, Gill JH. Citromycetins and bilains A-C: new aromatic polyketides and diketopiperazines from Australian marine-derived and terrestrial Penicillium spp. Journal of Natural Products. 70: 1746-52. PMID 17958395 DOI: 10.1021/Np0702483 |
0.499 |
|
| 2007 |
Ratnayake R, Lacey E, Tennant S, Gill JH, Capon RJ. Kibdelones: novel anticancer polyketides from a rare Australian actinomycete. Chemistry (Weinheim An Der Bergstrasse, Germany). 13: 1610-9. PMID 17091523 DOI: 10.1002/Chem.200601236 |
0.509 |
|
| 2006 |
Ratnayake R, Lacey E, Tennant S, Gill JH, Capon RJ. Isokibdelones: novel heterocyclic polyketides from a Kibdelosporangium sp. Organic Letters. 8: 5267-70. PMID 17078694 DOI: 10.1021/Ol062113E |
0.531 |
|
| 2005 |
Capon RJ, Ratnayake R, Stewart M, Lacey E, Tennant S, Gill JH. Aspergillazines A-E: novel heterocyclic dipeptides from an Australian strain of Aspergillus unilateralis. Organic & Biomolecular Chemistry. 3: 123-9. PMID 15602607 DOI: 10.1039/B413440K |
0.523 |
|
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