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A. James Link, Ph.D. - Publications

Affiliations: 
chemical and biological engineering Princeton University, Princeton, NJ 
Area:
protein engineering, natural products
Website:
http://www.princeton.edu/~ajlgroup
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56 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Elashal HE, Koos JD, Cheung-Lee WL, Choi B, Cao L, Richardson MA, White HL, Link AJ. Biosynthesis and characterization of fuscimiditide, an aspartimidylated graspetide. Nature Chemistry. PMID 35982233 DOI: 10.1038/s41557-022-01022-y  0.349
2022 Do T, Link AJ. Protein Engineering in Ribosomally Synthesized and Post-translationally Modified Peptides (RiPPs). Biochemistry. PMID 35006671 DOI: 10.1021/acs.biochem.1c00714  0.398
2021 Cao L, Beiser M, Koos JD, Orlova M, Elashal HE, Schröder HV, Link AJ. Cellulonodin-2 and Lihuanodin: Lasso Peptides with an Aspartimide Post-Translational Modification. Journal of the American Chemical Society. PMID 34283601 DOI: 10.1021/jacs.1c05017  0.312
2020 Chou WK, Vaikunthan M, Schröder HV, Link AJ, Kim H, Brynildsen MP. Synergy Screening Identifies a Compound That Selectively Enhances the Antibacterial Activity of Nitric Oxide. Frontiers in Bioengineering and Biotechnology. 8: 1001. PMID 32984281 DOI: 10.3389/Fbioe.2020.01001  0.309
2020 Montalbán-López M, Scott TA, Ramesh S, Rahman IR, van Heel AJ, Viel JH, Bandarian V, Dittmann E, Genilloud O, Goto Y, Grande Burgos MJ, Hill C, Kim S, Koehnke J, Latham JA, ... Link AJ, et al. New developments in RiPP discovery, enzymology and engineering. Natural Product Reports. PMID 32935693 DOI: 10.1039/D0Np00027B  0.328
2019 Cheung-Lee WL, Parry M, Zong C, Jaramillo Cartagena A, Darst S, Connell N, Russo R, Link AJ. Discovery of ubonodin, an antimicrobial lasso peptide active against members of the Burkholderia cepacia complex. Chembiochem : a European Journal of Chemical Biology. PMID 31765515 DOI: 10.1002/Cbic.201900707  0.386
2019 Cheung-Lee WL, Cao L, Link AJ. Pandonodin: a proteobacterial lasso peptide with an exceptionally long C-terminal tail. Acs Chemical Biology. PMID 31742991 DOI: 10.1021/Acschembio.9B00676  0.41
2019 Cheung-Lee WL, Link AJ. Genome mining for lasso peptides: past, present, and future. Journal of Industrial Microbiology & Biotechnology. PMID 31165971 DOI: 10.1007/S10295-019-02197-Z  0.366
2019 Cheung-Lee WL, Parry ME, Jaramillo Cartagena A, Darst SA, Link AJ. Discovery and structure of the antimicrobial lasso peptide citrocin. The Journal of Biological Chemistry. PMID 30846564 DOI: 10.1074/Jbc.Ra118.006494  0.405
2018 Koos JD, Link AJ. Heterologous and in vitro reconstitution of fuscanodin, a lasso peptide from Thermobifida fusca. Journal of the American Chemical Society. PMID 30532970 DOI: 10.1021/Jacs.8B10724  0.406
2018 Elashal HE, Cohen RD, Elashal HE, Zong C, Link AJ, Raj M. Cyclic and Lasso Peptides: Sequence Determination, Topology Analysis, and Rotaxane Formation. Angewandte Chemie (International Ed. in English). PMID 29645322 DOI: 10.1002/Anie.201801299  0.387
2017 Zong C, Wu MJ, Qin JZ, Link AJ. Lasso peptide benenodin-1 is a thermally actuated [1]rotaxane switch. Journal of the American Chemical Society. PMID 28696674 DOI: 10.1021/Jacs.7B04830  0.375
2016 Chekan JR, Koos JD, Zong C, Maksimov MO, Link AJ, Nair SK. Structure of the Lasso Peptide Isopeptidase Identifies a Topology for Processing Threaded Substrates. Journal of the American Chemical Society. 138: 16452-16458. PMID 27998080 DOI: 10.1021/Jacs.6B10389  0.4
2016 Cheung WL, Chen MY, Maksimov MO, Link AJ. Lasso Peptide Biosynthetic Protein LarB1 Binds Both Leader and Core Peptide Regions of the Precursor Protein LarA. Acs Central Science. 2: 702-709. PMID 27800552 DOI: 10.1021/Acscentsci.6B00184  0.45
2016 Allen CD, Link AJ. Self-Assembly of Catenanes from Lasso Peptides. Journal of the American Chemical Society. PMID 27768305 DOI: 10.1021/Jacs.6B09454  0.372
2016 Allen CD, Chen MY, Trick AY, Le DT, Ferguson AL, Link AJ. Thermal Unthreading of the Lasso Peptides Astexin-2 and Astexin-3. Acs Chemical Biology. PMID 27588549 DOI: 10.1021/Acschembio.6B00588  0.402
2016 Arnaudo AM, Link AJ, Garcia BA. Bioorthogonal Chemistry for the Isolation and Study of Newly Synthesized Histones and their Modifications. Acs Chemical Biology. PMID 26789204 DOI: 10.1021/Acschembio.5B00816  0.314
2015 Maksimov MO, Koos JD, Zong C, Lisko B, Link AJ. Elucidating the Specificity Determinants of the AtxE2 Lasso Peptide Isopeptidase. The Journal of Biological Chemistry. PMID 26534965 DOI: 10.1074/Jbc.M115.694083  0.398
2015 Zong C, Maksimov MO, Link AJ. Construction of Lasso Peptide Fusion Proteins. Acs Chemical Biology. PMID 26492187 DOI: 10.1021/acschembio.5b00745  0.334
2015 Link AJ. Biosynthesis: Leading the way to RiPPs. Nature Chemical Biology. 11: 551-2. PMID 26196773 DOI: 10.1038/Nchembio.1862  0.384
2015 Piscotta FJ, Tharp JM, Liu WR, Link AJ. Expanding the chemical diversity of lasso peptide MccJ25 with genetically encoded noncanonical amino acids. Chemical Communications (Cambridge, England). 51: 409-12. PMID 25407838 DOI: 10.1039/C4Cc07778D  0.449
2014 Abdeljabbar DM, Piscotta FJ, Zhang S, Link AJ. Protein stapling via azide–alkyne ligation Chemical Communications. 50: 14900-14903. PMID 25325394 DOI: 10.1039/C4Cc06528J  0.37
2014 Maksimov MO, Link AJ. Prospecting genomes for lasso peptides. Journal of Industrial Microbiology & Biotechnology. 41: 333-44. PMID 24142336 DOI: 10.1007/S10295-013-1357-4  0.356
2013 Arnison PG, Bibb MJ, Bierbaum G, Bowers AA, Bugni TS, Bulaj G, Camarero JA, Campopiano DJ, Challis GL, Clardy J, Cotter PD, Craik DJ, Dawson M, Dittmann E, Donadio S, ... ... Link AJ, et al. Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature. Natural Product Reports. 30: 108-60. PMID 23165928 DOI: 10.1039/C2Np20085F  0.349
2013 Arnison PG, Bibb MJ, Bierbaum G, Bowers AA, Bugni TS, Bulaj G, Camarero JA, Campopiano DJ, Challis GL, Clardy J, Cotter PD, Craik DJ, Dawson M, Dittmann E, Donadio S, ... ... Link AJ, et al. Erratum: Ribosomally synthesized and post-translationally modified peptide natural products: Overview and recommendations for a universal nomenclature (Natural Product Reports (2013) 30 (108-160) DOI:10.1039/C2NP20085F) Natural Product Reports. 30: 1568-1568. DOI: 10.1039/C3Np90040A  0.337
2013 Pan SJ, Cheung WL, Zhang S, Maksimov M, Link AJ. How to tie a peptide knot Acs Symposium Series. 1125: 113-127. DOI: 10.1021/bk-2013-1125.ch007  0.599
2012 Zhang S, Long A, Link AJ. A comparison of two strategies for affinity maturation of a BH3 peptide toward pro-survival Bcl-2 proteins. Acs Synthetic Biology. 1: 89-98. PMID 23651073 DOI: 10.1021/Sb200002M  0.365
2012 Maksimov MO, Pelczer I, Link AJ. Precursor-centric genome-mining approach for lasso peptide discovery. Proceedings of the National Academy of Sciences of the United States of America. 109: 15223-8. PMID 22949633 DOI: 10.1073/Pnas.1208978109  0.43
2012 Pan SJ, Rajniak J, Maksimov MO, Link AJ. The role of a conserved threonine residue in the leader peptide of lasso peptide precursors. Chemical Communications (Cambridge, England). 48: 1880-2. PMID 22222556 DOI: 10.1039/C2Cc17211A  0.649
2012 Pan SJ, Rajniak J, Cheung WL, Link AJ. Construction of a single polypeptide that matures and exports the lasso peptide microcin J25. Chembiochem : a European Journal of Chemical Biology. 13: 367-70. PMID 22213148 DOI: 10.1002/Cbic.201100596  0.625
2012 Abdeljabbar DM, Song HJ, Link AJ. Trichoderma reesei cellobiohydrolase II is associated with the outer membrane when overexpressed in Escherichia coli. Biotechnology Letters. 34: 91-6. PMID 21956129 DOI: 10.1007/S10529-011-0743-0  0.328
2011 Pan SJ, Link AJ. Sequence diversity in the lasso peptide framework: discovery of functional microcin J25 variants with multiple amino acid substitutions. Journal of the American Chemical Society. 133: 5016-23. PMID 21391585 DOI: 10.1021/Ja1109634  0.68
2011 Pan SJ, Cheung WL, Fung HK, Floudas CA, Link AJ. Computational design of the lasso peptide antibiotic microcin J25. Protein Engineering, Design & Selection : Peds. 24: 275-82. PMID 21106549 DOI: 10.1093/Protein/Gzq108  0.676
2010 Mannoor MS, Zhang S, Link AJ, McAlpine MC. Electrical detection of pathogenic bacteria via immobilized antimicrobial peptides. Proceedings of the National Academy of Sciences of the United States of America. 107: 19207-12. PMID 20956332 DOI: 10.1073/Pnas.1008768107  0.371
2010 Cheung WL, Pan SJ, Link AJ. Much of the microcin J25 leader peptide is dispensable. Journal of the American Chemical Society. 132: 2514-5. PMID 20143810 DOI: 10.1021/Ja910191U  0.667
2010 Pan SJ, Cheung WL, Link AJ. Engineered gene clusters for the production of the antimicrobial peptide microcin J25. Protein Expression and Purification. 71: 200-6. PMID 20035874 DOI: 10.1016/J.Pep.2009.12.010  0.594
2009 Abdeljabbar DM, Klein TJ, Zhang S, Link AJ. A single genomic copy of an engineered methionyl-tRNA synthetase enables robust incorporation of azidonorleucine into recombinant proteins in E. coli. Journal of the American Chemical Society. 131: 17078-9. PMID 19894713 DOI: 10.1021/Ja907969M  0.424
2009 Sun J, Abdeljabbar DM, Clarke N, Bellows ML, Floudas CA, Link AJ. Reconstitution and engineering of apoptotic protein interactions on the bacterial cell surface. Journal of Molecular Biology. 394: 297-305. PMID 19766123 DOI: 10.1016/J.Jmb.2009.09.023  0.391
2009 Tang Y, Wang P, Van Deventer JA, Link AJ, Tirrell DA. Introduction of an aliphatic ketone into recombinant proteins in a bacterial strain that overexpresses an editing-impaired leucyl-tRNA synthetase. Chembiochem : a European Journal of Chemical Biology. 10: 2188-90. PMID 19670197 DOI: 10.1002/Cbic.200900407  0.761
2009 Xu LY, Link AJ. Stress responses to heterologous membrane protein expression in Escherichia coli. Biotechnology Letters. 31: 1775-82. PMID 19588252 DOI: 10.1007/S10529-009-0075-5  0.33
2008 Link AJ, Skretas G, Strauch EM, Chari NS, Georgiou G. Efficient production of membrane-integrated and detergent-soluble G protein-coupled receptors in Escherichia coli. Protein Science : a Publication of the Protein Society. 17: 1857-63. PMID 18593817 DOI: 10.1110/Ps.035980.108  0.654
2008 Strable E, Prasuhn DE, Udit AK, Brown S, Link AJ, Ngo JT, Lander G, Quispe J, Potter CS, Carragher B, Tirrell DA, Finn MG. Unnatural amino acid incorporation into virus-like particles. Bioconjugate Chemistry. 19: 866-75. PMID 18318461 DOI: 10.1021/Bc700390R  0.716
2007 Yoo TH, Link AJ, Tirrell DA. Evolution of a fluorinated green fluorescent protein. Proceedings of the National Academy of Sciences of the United States of America. 104: 13887-90. PMID 17717085 DOI: 10.1073/Pnas.0701904104  0.588
2007 Link AJ, Vink MK, Tirrell DA. Synthesis of the functionalizable methionine surrogate azidohomoalanine using Boc-homoserine as precursor. Nature Protocols. 2: 1884-7. PMID 17703199 DOI: 10.1038/Nprot.2007.269  0.525
2007 Link AJ, Vink MK, Tirrell DA. Preparation of the functionalizable methionine surrogate azidohomoalanine via copper-catalyzed diazo transfer. Nature Protocols. 2: 1879-83. PMID 17703198 DOI: 10.1038/Nprot.2007.268  0.554
2007 Link AJ, Jeong KJ, Georgiou G. Beyond toothpicks: new methods for isolating mutant bacteria. Nature Reviews. Microbiology. 5: 680-8. PMID 17676054 DOI: 10.1038/Nrmicro1715  0.435
2007 Dieterich DC, Lee JJ, Link AJ, Graumann J, Tirrell DA, Schuman EM. Labeling, detection and identification of newly synthesized proteomes with bioorthogonal non-canonical amino-acid tagging. Nature Protocols. 2: 532-40. PMID 17406607 DOI: 10.1038/Nprot.2007.52  0.614
2007 Link AJ, Georgiou G. Advances and challenges in membrane protein expression Aiche Journal. 53: 752-756. DOI: 10.1002/Aic.11107  0.474
2006 Link AJ, Vink MK, Agard NJ, Prescher JA, Bertozzi CR, Tirrell DA. Discovery of aminoacyl-tRNA synthetase activity through cell-surface display of noncanonical amino acids. Proceedings of the National Academy of Sciences of the United States of America. 103: 10180-5. PMID 16801548 DOI: 10.1073/Pnas.0601167103  0.596
2006 Dieterich DC, Link AJ, Graumann J, Tirrell DA, Schuman EM. Selective identification of newly synthesized proteins in mammalian cells using bioorthogonal noncanonical amino acid tagging (BONCAT). Proceedings of the National Academy of Sciences of the United States of America. 103: 9482-7. PMID 16769897 DOI: 10.1073/Pnas.0601637103  0.605
2006 Link AJ, Jeong K, Georgiou G. Expression of soluble and membrane proteins in E. coli Microbial Cell Factories. 5: 1-1. DOI: 10.1186/1475-2859-5-S1-S15  0.49
2005 Link AJ, Tirrell DA. Reassignment of sense codons in vivo. Methods (San Diego, Calif.). 36: 291-8. PMID 16076455 DOI: 10.1016/J.Ymeth.2005.04.005  0.606
2005 Van Deventer JA, Link AJ, Tang Y, Wang P, Tirrell DA. Incorporation and labeling of an aliphatic ketone in recombinant proteins Aiche Annual Meeting, Conference Proceedings. 8700.  0.718
2004 Link AJ, Vink MK, Tirrell DA. Presentation and detection of azide functionality in bacterial cell surface proteins. Journal of the American Chemical Society. 126: 10598-602. PMID 15327317 DOI: 10.1021/Ja047629C  0.525
2003 Link AJ, Tirrell DA. Cell surface labeling of Escherichia coli via copper(I)-catalyzed [3+2] cycloaddition. Journal of the American Chemical Society. 125: 11164-5. PMID 16220915 DOI: 10.1021/Ja036765Z  0.568
2003 Link AJ, Mock ML, Tirrell DA. Non-canonical amino acids in protein engineering. Current Opinion in Biotechnology. 14: 603-9. PMID 14662389 DOI: 10.1016/J.Copbio.2003.10.011  0.756
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