Kevin M. Haigis, Ph.D. - Publications

Affiliations: 
2002 University of Wisconsin, Madison, Madison, WI 
Area:
Genetics, Oncology

45 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Poulin EJ, Bera AK, Lu J, Lin YJ, Strasser SD, Paulo JA, Huang TQ, Morales C, Yan W, Cook J, Nowak JA, Brubaker DK, Joughin BA, Johnson CW, DeStefanis RA, ... ... Haigis KM, et al. Tissue-specific oncogenic activity of K-RasA146T. Cancer Discovery. PMID 30952657 DOI: 10.1158/2159-8290.CD-18-1220  0.68
2018 Lyons J, Ghazi PC, Starchenko A, Tovaglieri A, Baldwin KR, Poulin EJ, Gierut JJ, Genetti C, Yajnik V, Breault DT, Lauffenburger DA, Haigis KM. The colonic epithelium plays an active role in promoting colitis by shaping the tissue cytokine profile. Plos Biology. 16: e2002417. PMID 29596476 DOI: 10.1371/journal.pbio.2002417  0.68
2015 Gierut JJ, Wood LB, Lau KS, Lin YJ, Genetti C, Samatar AA, Lauffenburger DA, Haigis KM. Network-level effects of kinase inhibitors modulate TNF-α-induced apoptosis in the intestinal epithelium. Science Signaling. 8: ra129. PMID 26671150 DOI: 10.1126/scisignal.aac7235  0.36
2015 Wood LB, Winslow AR, Proctor EA, McGuone D, Mordes DA, Frosch MP, Hyman BT, Lauffenburger DA, Haigis KM. Identification of neurotoxic cytokines by profiling Alzheimer's disease tissues and neuron culture viability screening. Scientific Reports. 5: 16622. PMID 26564777 DOI: 10.1038/srep16622  0.36
2015 Gierut JJ, Lyons J, Shah MS, Genetti C, Breault DT, Haigis KM. Oncogenic K-Ras promotes proliferation in quiescent intestinal stem cells. Stem Cell Research. 15: 165-71. PMID 26079371 DOI: 10.1016/j.scr.2015.06.003  0.36
2015 Depeille P, Henricks LM, van de Ven RA, Lemmens E, Wang CY, Matli M, Werb Z, Haigis KM, Donner D, Warren R, Roose JP. RasGRP1 opposes proliferative EGFR-SOS1-Ras signals and restricts intestinal epithelial cell growth. Nature Cell Biology. 17: 804-15. PMID 26005835 DOI: 10.1038/ncb3175  0.36
2015 Bender RH, Haigis KM, Gutmann DH. Activated k-ras, but not h-ras or N-ras, regulates brain neural stem cell proliferation in a raf/rb-dependent manner. Stem Cells (Dayton, Ohio). 33: 1998-2010. PMID 25788415 DOI: 10.1002/stem.1990  0.36
2015 Tsai FD, Lopes MS, Zhou M, Court H, Ponce O, Fiordalisi JJ, Gierut JJ, Cox AD, Haigis KM, Philips MR. K-Ras4A splice variant is widely expressed in cancer and uses a hybrid membrane-targeting motif. Proceedings of the National Academy of Sciences of the United States of America. 112: 779-84. PMID 25561545 DOI: 10.1073/pnas.1412811112  0.36
2014 Burgess MR, Hwang E, Firestone AJ, Huang T, Xu J, Zuber J, Bohin N, Wen T, Kogan SC, Haigis KM, Sampath D, Lowe S, Shannon K, Li Q. Preclinical efficacy of MEK inhibition in Nras-mutant AML. Blood. 124: 3947-55. PMID 25361812 DOI: 10.1182/blood-2014-05-574582  0.36
2014 Jun HJ, Roy J, Smith TB, Wood LB, Lane K, Woolfenden S, Punko D, Bronson RT, Haigis KM, Breton S, Charest A. ROS1 signaling regulates epithelial differentiation in the epididymis. Endocrinology. 155: 3661-73. PMID 24971615 DOI: 10.1210/en.2014-1341  0.36
2014 Imamura Y, Lochhead P, Yamauchi M, Kuchiba A, Qian ZR, Liao X, Nishihara R, Jung S, Wu K, Nosho K, Wang YE, Peng S, Bass AJ, Haigis KM, Meyerhardt JA, et al. Analyses of clinicopathological, molecular, and prognostic associations of KRAS codon 61 and codon 146 mutations in colorectal cancer: cohort study and literature review. Molecular Cancer. 13: 135. PMID 24885062 DOI: 10.1186/1476-4598-13-135  0.36
2014 Gierut JJ, Jacks TE, Haigis KM. Whole-mount X-Gal staining of mouse tissues. Cold Spring Harbor Protocols. 2014: 417-9. PMID 24692489 DOI: 10.1101/pdb.prot073452  0.68
2014 Gierut JJ, Jacks TE, Haigis KM. Strategies to achieve conditional gene mutation in mice. Cold Spring Harbor Protocols. 2014: 339-49. PMID 24692485 DOI: 10.1101/pdb.top069807  0.68
2014 Gierut JJ, Jacks TE, Haigis KM. In vivo delivery of lenti-Cre or adeno-Cre into mice using intranasal instillation. Cold Spring Harbor Protocols. 2014: 307-9. PMID 24591689 DOI: 10.1101/pdb.prot073445  0.68
2014 Gierut JJ, Jacks TE, Haigis KM. Producing and concentrating lenti-Cre for mouse infections. Cold Spring Harbor Protocols. 2014: 304-6. PMID 24591688 DOI: 10.1101/pdb.prot073437  0.68
2014 Russo AL, Borger DR, Szymonifka J, Ryan DP, Wo JY, Blaszkowsky LS, Kwak EL, Allen JN, Wadlow RC, Zhu AX, Murphy JE, Faris JE, Dias-Santagata D, Haigis KM, Ellisen LW, et al. Mutational analysis and clinical correlation of metastatic colorectal cancer. Cancer. 120: 1482-90. PMID 24500602 DOI: 10.1002/cncr.28599  0.36
2014 Russo AL, Ryan DP, Borger DR, Wo JY, Szymonifka J, Liang WY, Kwak EL, Blaszkowsky LS, Clark JW, Allen JN, Zhu AX, Berger DL, Cusack JC, Mamon HJ, Haigis KM, et al. Mutational and clinical predictors of pathologic complete response in the treatment of locally advanced rectal cancer. Journal of Gastrointestinal Cancer. 45: 34-9. PMID 24006244 DOI: 10.1007/s12029-013-9546-y  0.36
2013 Lau KS, Schrier SB, Gierut J, Lyons J, Lauffenburger DA, Haigis KM. Network analysis of differential Ras isoform mutation effects on intestinal epithelial responses to TNF-α. Integrative Biology : Quantitative Biosciences From Nano to Macro. 5: 1355-65. PMID 24084984 DOI: 10.1039/c3ib40062j  0.36
2013 Yang MH, Laurent G, Bause AS, Spang R, German N, Haigis MC, Haigis KM. HDAC6 and SIRT2 regulate the acetylation state and oncogenic activity of mutant K-RAS. Molecular Cancer Research : McR. 11: 1072-7. PMID 23723075 DOI: 10.1158/1541-7786.MCR-13-0040-T  0.36
2013 Miraldi ER, Sharfi H, Friedline RH, Johnson H, Zhang T, Lau KS, Ko HJ, Curran TG, Haigis KM, Yaffe MB, Bonneau R, Lauffenburger DA, Kahn BB, Kim JK, Neel BG, et al. Molecular network analysis of phosphotyrosine and lipid metabolism in hepatic PTP1b deletion mice. Integrative Biology : Quantitative Biosciences From Nano to Macro. 5: 940-63. PMID 23685806 DOI: 10.1039/c3ib40013a  0.36
2013 Cho H, Hashimoto T, Wong E, Hori Y, Wood LB, Zhao L, Haigis KM, Hyman BT, Irimia D. Microfluidic chemotaxis platform for differentiating the roles of soluble and bound amyloid-β on microglial accumulation. Scientific Reports. 3: 1823. PMID 23665843 DOI: 10.1038/srep01823  0.36
2013 Wang Y, Velho S, Vakiani E, Peng S, Bass AJ, Chu GC, Gierut J, Bugni JM, Der CJ, Philips M, Solit DB, Haigis KM. Mutant N-RAS protects colorectal cancer cells from stress-induced apoptosis and contributes to cancer development and progression. Cancer Discovery. 3: 294-307. PMID 23274911 DOI: 10.1158/2159-8290.CD-12-0198  0.36
2012 Mitra D, Luo X, Morgan A, Wang J, Hoang MP, Lo J, Guerrero CR, Lennerz JK, Mihm MC, Wargo JA, Robinson KC, Devi SP, Vanover JC, D'Orazio JA, McMahon M, ... ... Haigis KM, et al. An ultraviolet-radiation-independent pathway to melanoma carcinogenesis in the red hair/fair skin background. Nature. 491: 449-53. PMID 23123854 DOI: 10.1038/nature11624  0.36
2012 Lau KS, Cortez-Retamozo V, Philips SR, Pittet MJ, Lauffenburger DA, Haigis KM. Multi-scale in vivo systems analysis reveals the influence of immune cells on TNF-α-induced apoptosis in the intestinal epithelium. Plos Biology. 10: e1001393. PMID 23055830 DOI: 10.1371/journal.pbio.1001393  0.36
2012 Yang MH, Nickerson S, Kim ET, Liot C, Laurent G, Spang R, Philips MR, Shan Y, Shaw DE, Bar-Sagi D, Haigis MC, Haigis KM. Regulation of RAS oncogenicity by acetylation. Proceedings of the National Academy of Sciences of the United States of America. 109: 10843-8. PMID 22711838 DOI: 10.1073/pnas.1201487109  0.36
2012 Hong TS, Clark JW, Haigis KM. Cancers of the colon and rectum: identical or fraternal twins? Cancer Discovery. 2: 117-21. PMID 22585856 DOI: 10.1158/2159-8290.CD-11-0315  0.36
2012 Powell AE, Wang Y, Li Y, Poulin EJ, Means AL, Washington MK, Higginbotham JN, Juchheim A, Prasad N, Levy SE, Guo Y, Shyr Y, Aronow BJ, Haigis KM, Franklin JL, et al. The pan-ErbB negative regulator Lrig1 is an intestinal stem cell marker that functions as a tumor suppressor. Cell. 149: 146-58. PMID 22464327 DOI: 10.1016/j.cell.2012.02.042  0.36
2012 Xu J, Hedberg C, Dekker FJ, Li Q, Haigis KM, Hwang E, Waldmann H, Shannon K. Inhibiting the palmitoylation/depalmitoylation cycle selectively reduces the growth of hematopoietic cells expressing oncogenic Nras. Blood. 119: 1032-5. PMID 22144181 DOI: 10.1182/blood-2011-06-358960  0.36
2011 Lau KS, Juchheim AM, Cavaliere KR, Philips SR, Lauffenburger DA, Haigis KM. In vivo systems analysis identifies spatial and temporal aspects of the modulation of TNF-α-induced apoptosis and proliferation by MAPKs. Science Signaling. 4: ra16. PMID 21427409 DOI: 10.1126/scisignal.2001338  0.36
2011 Haigis KM, Sweet-Cordero A. New insights into oncogenic stress. Nature Genetics. 43: 177-8. PMID 21350495 DOI: 10.1038/ng0311-177  0.44
2011 Li Q, Haigis KM, McDaniel A, Harding-Theobald E, Kogan SC, Akagi K, Wong JC, Braun BS, Wolff L, Jacks T, Shannon K. Hematopoiesis and leukemogenesis in mice expressing oncogenic NrasG12D from the endogenous locus. Blood. 117: 2022-32. PMID 21163920 DOI: 10.1182/blood-2010-04-280750  0.36
2010 Tanaka N, Huttenhower C, Nosho K, Baba Y, Shima K, Quackenbush J, Haigis KM, Giovannucci E, Fuchs CS, Ogino S. Novel application of structural equation modeling to correlation structure analysis of CpG island methylation in colorectal cancer. The American Journal of Pathology. 177: 2731-40. PMID 21037082 DOI: 10.2353/ajpath.2010.100361  0.36
2010 Kreeger PK, Wang Y, Haigis KM, Lauffenburger DA. Integration of multiple signaling pathway activities resolves K-RAS/N-RAS mutation paradox in colon epithelial cell response to inflammatory cytokine stimulation. Integrative Biology : Quantitative Biosciences From Nano to Macro. 2: 202-8. PMID 20473400 DOI: 10.1039/b925935j  0.36
2010 Kirsch DG, Santiago PM, di Tomaso E, Sullivan JM, Hou WS, Dayton T, Jeffords LB, Sodha P, Mercer KL, Cohen R, Takeuchi O, Korsmeyer SJ, Bronson RT, Kim CF, Haigis KM, et al. p53 controls radiation-induced gastrointestinal syndrome in mice independent of apoptosis. Science (New York, N.Y.). 327: 593-6. PMID 20019247 DOI: 10.1126/science.1166202  0.36
2010 Cheung AF, Carter AM, Kostova KK, Woodruff JF, Crowley D, Bronson RT, Haigis KM, Jacks T. Complete deletion of Apc results in severe polyposis in mice. Oncogene. 29: 1857-64. PMID 20010873 DOI: 10.1038/onc.2009.457  0.36
2009 Lau KS, Haigis KM. Non-redundancy within the RAS oncogene family: insights into mutational disparities in cancer. Molecules and Cells. 28: 315-20. PMID 19812895 DOI: 10.1007/s10059-009-0143-7  0.36
2009 Kreeger PK, Mandhana R, Alford SK, Haigis KM, Lauffenburger DA. RAS mutations affect tumor necrosis factor-induced apoptosis in colon carcinoma cells via ERK-modulatory negative and positive feedback circuits along with non-ERK pathway effects. Cancer Research. 69: 8191-9. PMID 19789336 DOI: 10.1158/0008-5472.CAN-09-1921  0.36
2009 Matharu KS, Mizoguchi E, Cotoner CA, Nguyen DD, Mingle B, Iweala OI, McBee ME, Stefka AT, Prioult G, Haigis KM, Bhan AK, Snapper SB, Murakami H, Schauer DB, Reinecker HC, et al. Toll-Like Receptor 4-Mediated Regulation of Spontaneous Helicobacter-Dependent Colitis in IL-10-Deficient Mice Gastroenterology. 137: 1380-1390.e3. PMID 19596011 DOI: 10.1053/j.gastro.2009.07.004  0.36
2008 Morris EJ, Ji JY, Yang F, Di Stefano L, Herr A, Moon NS, Kwon EJ, Haigis KM, Näär AM, Dyson NJ. E2F1 represses beta-catenin transcription and is antagonized by both pRB and CDK8. Nature. 455: 552-6. PMID 18794899 DOI: 10.1038/nature07310  0.36
2008 Haigis KM, Kendall KR, Wang Y, Cheung A, Haigis MC, Glickman JN, Niwa-Kawakita M, Sweet-Cordero A, Sebolt-Leopold J, Shannon KM, Settleman J, Giovannini M, Jacks T. Differential effects of oncogenic K-Ras and N-Ras on proliferation, differentiation and tumor progression in the colon. Nature Genetics. 40: 600-8. PMID 18372904 DOI: 10.1038/ng.115  0.36
2007 Kissil JL, Walmsley MJ, Hanlon L, Haigis KM, Bender Kim CF, Sweet-Cordero A, Eckman MS, Tuveson DA, Capobianco AJ, Tybulewicz VL, Jacks T. Requirement for Rac1 in a K-ras induced lung cancer in the mouse. Cancer Research. 67: 8089-94. PMID 17804720 DOI: 10.1158/0008-5472.CAN-07-2300  0.36
2007 Poutahidis T, Haigis KM, Rao VP, Nambiar PR, Taylor CL, Ge Z, Watanabe K, Davidson A, Horwitz BH, Fox JG, Erdman SE. Rapid reversal of interleukin-6-dependent epithelial invasion in a mouse model of microbially induced colon carcinoma. Carcinogenesis. 28: 2614-23. PMID 17724375 DOI: 10.1093/carcin/bgm180  0.36
2007 Keller JW, Haigis KM, Franklin JL, Whitehead RH, Jacks T, Coffey RJ. Oncogenic K-RAS subverts the antiapoptotic role of N-RAS and alters modulation of the N-RAS:gelsolin complex. Oncogene. 26: 3051-9. PMID 17130841 DOI: 10.1038/sj.onc.1210103  0.36
2006 Haigis MC, Mostoslavsky R, Haigis KM, Fahie K, Christodoulou DC, Murphy AJ, Valenzuela DM, Yancopoulos GD, Karow M, Blander G, Wolberger C, Prolla TA, Weindruch R, Alt FW, Guarente L. SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells. Cell. 126: 941-54. PMID 16959573 DOI: 10.1016/j.cell.2006.06.057  0.36
2004 Haigis KM, Hoff PD, White A, Shoemaker AR, Halberg RB, Dove WF. Tumor regionality in the mouse intestine reflects the mechanism of loss of Apc function. Proceedings of the National Academy of Sciences of the United States of America. 101: 9769-73. PMID 15210940 DOI: 10.1073/pnas.0403338101  0.36
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