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Denise A. Chan, Ph.D. - Publications

Affiliations: 
2004 Stanford University, Palo Alto, CA 
Area:
Molecular Biology, Oncology
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46 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2018 Ko SH, Nauta AC, Morrison SD, Hu MS, Zimmermann AS, Chung MT, Glotzbach JP, Wong VW, Walmsley GG, Peter Lorenz H, Chan DA, Gurtner GC, Giaccia AJ, Longaker MT. PHD-2 Suppression in Mesenchymal Stromal Cells Enhances Wound Healing. Plastic and Reconstructive Surgery. 141: 55e-67e. PMID 29280872 DOI: 10.1097/Prs.0000000000003959  0.548
2014 Zimmermann AS, Morrison SD, Hu MS, Li S, Nauta A, Sorkin M, Meyer NP, Walmsley GG, Maan ZN, Chan DA, Gurtner GC, Giaccia AJ, Longaker MT. Epidermal or dermal specific knockout of PHD-2 enhances wound healing and minimizes ischemic injury. Plos One. 9: e93373. PMID 24695462 DOI: 10.1371/Journal.Pone.0093373  0.521
2014 Bonnet M, Flanagan JU, Chan DA, Giaccia AJ, Hay MP. Identifying novel targets in renal cell carcinoma: design and synthesis of affinity chromatography reagents. Bioorganic & Medicinal Chemistry. 22: 711-20. PMID 24387866 DOI: 10.1016/J.Bmc.2013.12.028  0.5
2012 Anbalagan S, Pires IM, Blick C, Hill MA, Ferguson DJ, Chan DA, Hammond EM. Radiosensitization of renal cell carcinoma in vitro through the induction of autophagy. Radiotherapy and Oncology : Journal of the European Society For Therapeutic Radiology and Oncology. 103: 388-93. PMID 22551566 DOI: 10.1016/j.radonc.2012.04.001  0.587
2012 Chan D, Pearson P, Vernier J, Hershenson S, Freddo J, Tabibiazar R, Giaccia A, O'Connor P. 571 Targeting the GLUT1 Transporter as a Novel Therapeutic Approach to Exploit the Dependency of Cancer Cells On the “Warburg Effect” European Journal of Cancer. 48: 175. DOI: 10.1016/S0959-8049(12)72368-7  0.43
2011 Chan DA, Sutphin PD, Nguyen P, Turcotte S, Lai EW, Banh A, Reynolds GE, Chi JT, Wu J, Solow-Cordero DE, Bonnet M, Flanagan JU, Bouley DM, Graves EE, Denny WA, et al. Targeting GLUT1 and the Warburg effect in renal cell carcinoma by chemical synthetic lethality. Science Translational Medicine. 3: 94ra70. PMID 21813754 DOI: 10.1126/Scitranslmed.3002394  0.707
2011 Bonnet M, Flanagan JU, Chan DA, Lai EW, Nguyen P, Giaccia AJ, Hay MP. SAR studies of 4-pyridyl heterocyclic anilines that selectively induce autophagic cell death in von Hippel-Lindau-deficient renal cell carcinoma cells. Bioorganic & Medicinal Chemistry. 19: 3347-56. PMID 21561782 DOI: 10.1016/J.Bmc.2011.04.042  0.53
2011 Chan DA, Giaccia AJ. Harnessing synthetic lethal interactions in anticancer drug discovery. Nature Reviews. Drug Discovery. 10: 351-64. PMID 21532565 DOI: 10.1038/Nrd3374  0.438
2011 Ko S, Nauta A, Huang M, Chan D, Gurtner G, Wu J, Giaccia A, Longaker M. Novel Prolyl Hydroxylase Domain-2 Short Hairpin RNA Interference Therapy For Diabetic Wound Healing Journal of Surgical Research. 165: 187. DOI: 10.1016/J.Jss.2010.11.630  0.36
2010 Patten DA, Lafleur VN, Robitaille GA, Chan DA, Giaccia AJ, Richard DE. Hypoxia-inducible factor-1 activation in nonhypoxic conditions: the essential role of mitochondrial-derived reactive oxygen species. Molecular Biology of the Cell. 21: 3247-57. PMID 20660157 DOI: 10.1091/Mbc.E10-01-0025  0.54
2010 Wiley M, Sweeney KR, Chan DA, Brown KM, McMurtrey C, Howard EW, Giaccia AJ, Blader IJ. Toxoplasma gondii activates hypoxia-inducible factor (HIF) by stabilizing the HIF-1alpha subunit via type I activin-like receptor kinase receptor signaling. The Journal of Biological Chemistry. 285: 26852-60. PMID 20581113 DOI: 10.1074/Jbc.M110.147041  0.617
2010 Chan DA, Giaccia AJ. PHD2 in tumour angiogenesis. British Journal of Cancer. 103: 1-5. PMID 20461086 DOI: 10.1038/Sj.Bjc.6605682  0.545
2010 Hay MP, Turcotte S, Flanagan JU, Bonnet M, Chan DA, Sutphin PD, Nguyen P, Giaccia AJ, Denny WA. 4-Pyridylanilinothiazoles that selectively target von Hippel-Lindau deficient renal cell carcinoma cells by inducing autophagic cell death. Journal of Medicinal Chemistry. 53: 787-97. PMID 19994864 DOI: 10.1021/Jm901457W  0.698
2010 Krieg AJ, Rankin EB, Chan D, Razorenova O, Fernandez S, Giaccia AJ. Regulation of the histone demethylase JMJD1A by hypoxia-inducible factor 1 alpha enhances hypoxic gene expression and tumor growth. Molecular and Cellular Biology. 30: 344-53. PMID 19858293 DOI: 10.1128/Mcb.00444-09  0.607
2010 Lai EW, Chan DA, Hay MP, Giaccia AJ. Abstract 67: Selective cytotoxic targeting of von Hippel-Lindau-deficient renal cell carcinoma cells Cancer Research. 70: 67-67. DOI: 10.1158/1538-7445.Am10-67  0.574
2009 Chan DA, Kawahara TL, Sutphin PD, Chang HY, Chi JT, Giaccia AJ. Tumor vasculature is regulated by PHD2-mediated angiogenesis and bone marrow-derived cell recruitment. Cancer Cell. 15: 527-38. PMID 19477431 DOI: 10.1016/J.Ccr.2009.04.010  0.706
2009 Ghosh AK, Shanafelt TD, Cimmino A, Taccioli C, Volinia S, Liu CG, Calin GA, Croce CM, Chan DA, Giaccia AJ, Secreto C, Wellik LE, Lee YK, Mukhopadhyay D, Kay NE. Aberrant regulation of pVHL levels by microRNA promotes the HIF/VEGF axis in CLL B cells. Blood. 113: 5568-74. PMID 19336759 DOI: 10.1182/Blood-2008-10-185686  0.594
2009 Ko SH, Chan DA, Glotzbach JP, Giaccia AJ, Gurtner GC, Longaker MT. Stabilization of hypoxia-inducible factor-1 enhances proangiogenic potential of bone marrow–derived mesenchymal stem cells Journal of the American College of Surgeons. 209: S88. DOI: 10.1016/J.Jamcollsurg.2009.06.218  0.514
2008 Choi CY, Chan DA, Paulmurugan R, Sutphin PD, Le QT, Koong AC, Zundel W, Gambhir SS, Giaccia AJ. Molecular imaging of hypoxia-inducible factor 1 alpha and von Hippel-Lindau interaction in mice. Molecular Imaging. 7: 139-46. PMID 19123984  0.776
2008 Huang M, Chan DA, Jia F, Xie X, Li Z, Hoyt G, Robbins RC, Chen X, Giaccia AJ, Wu JC. Short hairpin RNA interference therapy for ischemic heart disease. Circulation. 118: S226-33. PMID 18824759 DOI: 10.1161/Circulationaha.107.760785  0.588
2008 Chan DA, Giaccia AJ. Targeting cancer cells by synthetic lethality: autophagy and VHL in cancer therapeutics. Cell Cycle (Georgetown, Tex.). 7: 2987-90. PMID 18818511 DOI: 10.4161/Cc.7.19.6776  0.533
2008 Turcotte S, Chan DA, Sutphin PD, Hay MP, Denny WA, Giaccia AJ. A molecule targeting VHL-deficient renal cell carcinoma that induces autophagy. Cancer Cell. 14: 90-102. PMID 18598947 DOI: 10.1016/J.Ccr.2008.06.004  0.716
2008 Lauzier MC, Robitaille GA, Chan DA, Giaccia AJ, Richard DE. (2R)-[(4-Biphenylylsulfonyl)amino]-N-hydroxy-3-phenylpropionamide (BiPS), a matrix metalloprotease inhibitor, is a novel and potent activator of hypoxia-inducible factors. Molecular Pharmacology. 74: 282-8. PMID 18424552 DOI: 10.1124/Mol.108.045690  0.636
2008 Pagé EL, Chan DA, Giaccia AJ, Levine M, Richard DE. Hypoxia-inducible factor-1alpha stabilization in nonhypoxic conditions: role of oxidation and intracellular ascorbate depletion. Molecular Biology of the Cell. 19: 86-94. PMID 17942596 DOI: 10.1091/Mbc.E07-06-0612  0.631
2008 Giaccia AJ, Choi CYH, Chan DA, Paulmurugan R, Sutphin PD, Le QT, Koong AC, Zundel W, Gambhir SS. Molecular imaging of hypoxia-inducible factor 1α and von Hippel-Lindau interaction in mice Molecular Imaging. 7: 139-146. DOI: 10.2310/7290.2008.00017  0.741
2007 Chang EI, Loh SA, Ceradini DJ, Chang EI, Lin SE, Bastidas N, Aarabi S, Chan DA, Freedman ML, Giaccia AJ, Gurtner GC. Age decreases endothelial progenitor cell recruitment through decreases in hypoxia-inducible factor 1alpha stabilization during ischemia. Circulation. 116: 2818-29. PMID 18040029 DOI: 10.1161/Circulationaha.107.715847  0.542
2007 Chan DA, Krieg AJ, Turcotte S, Giaccia AJ. HIF gene expression in cancer therapy. Methods in Enzymology. 435: 323-45. PMID 17998061 DOI: 10.1016/S0076-6879(07)35016-7  0.631
2007 Cecic I, Chan DA, Sutphin PD, Ray P, Gambhir SS, Giaccia AJ, Graves EE. Oxygen sensitivity of reporter genes: implications for preclinical imaging of tumor hypoxia. Molecular Imaging. 6: 219-28. PMID 17711777 DOI: 10.2310/7290.2007.00017  0.7
2007 Sutphin PD, Chan DA, Li JM, Turcotte S, Krieg AJ, Giaccia AJ. Targeting the loss of the von Hippel-Lindau tumor suppressor gene in renal cell carcinoma cells. Cancer Research. 67: 5896-905. PMID 17575159 DOI: 10.1158/0008-5472.Can-07-0604  0.712
2007 Sutphin PD, Giaccia AJ, Chan DA. Energy regulation: HIF MXIes it up with the C-MYC powerhouse. Developmental Cell. 12: 845-6. PMID 17543856 DOI: 10.1016/J.Devcel.2007.05.006  0.695
2007 Chan DA, Giaccia AJ. Hypoxia, gene expression, and metastasis. Cancer Metastasis Reviews. 26: 333-9. PMID 17458506 DOI: 10.1007/s10555-007-9063-1  0.501
2007 Pan Y, Mansfield KD, Bertozzi CC, Rudenko V, Chan DA, Giaccia AJ, Simon MC. Multiple factors affecting cellular redox status and energy metabolism modulate hypoxia-inducible factor prolyl hydroxylase activity in vivo and in vitro. Molecular and Cellular Biology. 27: 912-25. PMID 17101781 DOI: 10.1128/Mcb.01223-06  0.625
2007 Cecic I, Chan DA, Sutphin PD, Ray P, Gambhir SS, Giaccia AJ, Graves EE. Oxygen Sensitivity of Reporter Genes: Implications for Preclinical Imaging of Tumor Hypoxia Molecular Imaging. 6: 7290.2007.00017. DOI: 10.2310/7290.2007.00017  0.677
2007 Lee P, Chan C, Hua A, Paulmurugan R, Chan D, Gambhir S, Le Q, Giaccia A. Noninvasive Monitoring of Ligand-Dependent VEGF Receptor-2 Dimerization With Split Firefly Luciferase International Journal of Radiation Oncology*Biology*Physics. 69: S96-S97. DOI: 10.1016/J.Ijrobp.2007.07.177  0.455
2006 Spear W, Chan D, Coppens I, Johnson RS, Giaccia A, Blader IJ. The host cell transcription factor hypoxia-inducible factor 1 is required for Toxoplasma gondii growth and survival at physiological oxygen levels. Cellular Microbiology. 8: 339-52. PMID 16441443 DOI: 10.1111/J.1462-5822.2005.00628.X  0.573
2006 Lee YK, Shanafelt T, Chan D, Giaccia A, Mukhopadhyay D, Taccioli C, Calin G, Croce C, Kay NE. Elevated HIF-1α Levels in CLL B Cells May Explain Their Autocrine VEGF Secretion. Blood. 108: 583-583. DOI: 10.1182/Blood.V108.11.583.583  0.546
2006 Choi C, Paulmurugan R, Chan D, Sutphin P, Le Q, Koong A, Gambhir S, Giaccia A. 83 International Journal of Radiation Oncology*Biology*Physics. 66: S48-S49. DOI: 10.1016/J.Ijrobp.2006.07.113  0.691
2005 Chan DA, Sutphin PD, Yen SE, Giaccia AJ. Coordinate regulation of the oxygen-dependent degradation domains of hypoxia-inducible factor 1 alpha. Molecular and Cellular Biology. 25: 6415-26. PMID 16024780 DOI: 10.1128/Mcb.25.15.6415-6426.2005  0.742
2005 Baek JH, Mahon PC, Oh J, Kelly B, Krishnamachary B, Pearson M, Chan DA, Giaccia AJ, Semenza GL. OS-9 interacts with hypoxia-inducible factor 1alpha and prolyl hydroxylases to promote oxygen-dependent degradation of HIF-1alpha. Molecular Cell. 17: 503-12. PMID 15721254 DOI: 10.1016/J.Molcel.2005.01.011  0.635
2005 Lee YK, Strege AK, Bone ND, Wellik LE, Chan DA, Giaccia AJ, Mukhopadhyay D, Kay NE. Hypoxia Inducible Factor-1α Is over Expressed in CLL B Cells Because of an Impaired Proteasome Pathway Associated with Defective Interaction with von Hippel-Landau Protein. Blood. 106: 2115-2115. DOI: 10.1182/Blood.V106.11.2115.2115  0.558
2004 Gerald D, Berra E, Frapart YM, Chan DA, Giaccia AJ, Mansuy D, Pouysségur J, Yaniv M, Mechta-Grigoriou F. JunD reduces tumor angiogenesis by protecting cells from oxidative stress Cell. 118: 781-794. PMID 15369676 DOI: 10.1016/J.Cell.2004.08.025  0.637
2004 Pfander D, Kobayashi T, Knight MC, Zelzer E, Chan DA, Olsen BR, Giaccia AJ, Johnson RS, Haase VH, Schipani E. Deletion of Vhlh in chondrocytes reduces cell proliferation and increases matrix deposition during growth plate development. Development (Cambridge, England). 131: 2497-508. PMID 15128677 DOI: 10.1242/Dev.01138  0.569
2004 Bemis L, Chan DA, Finkielstein CV, Qi L, Sutphin PD, Chen X, Stenmark K, Giaccia AJ, Zundel W. Distinct aerobic and hypoxic mechanisms of HIF-alpha regulation by CSN5. Genes & Development. 18: 739-44. PMID 15082527 DOI: 10.1101/Gad.1180104  0.772
2004 Sutphin PD, Chan DA, Giaccia AJ. Dead cells don't form tumors: HIF-dependent cytotoxins. Cell Cycle (Georgetown, Tex.). 3: 160-3. PMID 14712081  0.716
2004 Sutphin PD, Chan DA, Giaccia AJ. Dead Cells Don’t Form Tumors: HIF-Dependent Cytotoxins Cell Cycle. 3: 160-163. DOI: 10.4161/Cc.3.2.617  0.732
2002 Chan DA, Sutphin PD, Denko NC, Giaccia AJ. Role of prolyl hydroxylation in oncogenically stabilized hypoxia-inducible factor-1alpha. The Journal of Biological Chemistry. 277: 40112-7. PMID 12186875 DOI: 10.1074/Jbc.M206922200  0.744
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