Bradley W. Doble, Ph.D. - Publications

Affiliations: 
2001 University of Manitoba, Winnipeg, Manitoba, Canada 
Area:
Cell Biology, Molecular Biology

53 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Leatherdale A, Parker D, Tasneem S, Wang Y, Bihan D, Bonna A, Hamaia SW, Gross PL, Ni H, Doble BW, Lillicrap D, Farndale RW, Hayward CPM. Multimerin 1 supports platelet function in vivo and binds to specific GPAGPOGPX motifs in fibrillar collagens that enhance platelet adhesion. Journal of Thrombosis and Haemostasis : Jth. PMID 33179420 DOI: 10.1111/jth.15171  0.01
2020 Manoranjan B, Venugopal C, Bakhshinyan D, Adile AA, Richards L, Kameda-Smith MM, Whitley O, Dvorkin-Gheva A, Subapanditha M, Savage N, Tatari N, McKenna D, Bassey-Archibong B, Winegarden N, Hallett R, ... ... Doble BW, et al. Wnt activation as a therapeutic strategy in medulloblastoma. Nature Communications. 11: 4323. PMID 32859895 DOI: 10.1038/S41467-020-17953-4  1
2020 Zhang M, Lai Y, Krupalnik V, Guo P, Guo X, Zhou J, Xu Y, Yu Z, Liu L, Jiang A, Li W, Abdul MM, Ma G, Li N, Fu X, ... ... Doble BW, et al. β-Catenin safeguards the ground state of mousepluripotency by strengthening the robustness of the transcriptional apparatus. Science Advances. 6: eaba1593. PMID 32832621 DOI: 10.1126/Sciadv.Aba1593  1
2019 Manoranjan B, Chokshi C, Venugopal C, Subapanditha M, Savage N, Tatari N, Provias JP, Murty NK, Moffat J, Doble BW, Singh SK. A CD133-AKT-Wnt signaling axis drives glioblastoma brain tumor-initiating cells. Oncogene. PMID 31695152 DOI: 10.1038/S41388-019-1086-X  1
2018 Singh SK, Manoranjan B, Dvorkin-Gheva A, Venugopal C, Moreira S, Kameda-Smith M, Subapanditha M, Adile A, Bakhshinyan D, Savage N, Yarascavitch B, Ajani O, Fleming A, Doble B. Abstract 148: Canonical Wnt activation as a therapeutic strategy in pediatric medulloblastoma Tumor Biology. DOI: 10.1158/1538-7445.Am2018-148  1
2017 Moreira S, Polena E, Gordon V, Abdulla S, Mahendram S, Cao J, Blais A, Wood GA, Dvorkin-Gheva A, Doble BW. A Single TCF Transcription Factor, Regardless of Its Activation Capacity, Is Sufficient for Effective Trilineage Differentiation of ESCs. Cell Reports. 20: 2424-2438. PMID 28877475 DOI: 10.1016/J.Celrep.2017.08.043  1
2017 Manoranjan B, Venugopal C, Pavlovic Z, Bakhshinyan D, Kameda-Smith M, Subapanditha M, Mahendram S, Moffat J, Doble BW, Singh S. Abstract 5831: Activated Wnt signaling for the treatment of recurrent medulloblastoma Cancer Research. 77: 5831-5831. DOI: 10.1158/1538-7445.Am2017-5831  1
2016 Guezguez B, Almakadi M, Benoit YD, Shapovalova Z, Rahmig S, Fiebig-Comyn A, Casado FL, Tanasijevic B, Bresolin S, Masetti R, Doble BW, Bhatia M. GSK3 Deficiencies in Hematopoietic Stem Cells Initiate Pre-neoplastic State that Is Predictive of Clinical Outcomes of Human Acute Leukemia. Cancer Cell. 29: 61-74. PMID 26766591 DOI: 10.1016/J.Ccell.2015.11.012  0.01
2015 Singh SK, Venugopal C, Hallett R, Vora P, Manoranjan B, Mahendram S, Qazi M, McFarlane N, Subapanditha M, Nolte S, Singh M, Bakhshinyan D, Garg N, Vijayakumar T, Lach B, ... ... Doble B, et al. Pyrvinium targets CD133 in human glioblastoma brain tumor-initiating cells. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 26152745 DOI: 10.1158/1078-0432.Ccr-14-3147  1
2015 Khan KA, Dô F, Marineau A, Doyon P, Clément JF, Woodgett JR, Doble BW, Servant MJ. Fine-Tuning of the RIG-I-Like Receptor/Interferon Regulatory Factor 3-Dependent Antiviral Innate Immune Response by the Glycogen Synthase Kinase 3/β-Catenin Pathway. Molecular and Cellular Biology. 35: 3029-43. PMID 26100021 DOI: 10.1128/Mcb.00344-15  1
2015 Meredith GD, D'Ippolito A, Dudas M, Zeidner LC, Hostetter L, Faulds K, Arnold TH, Popkie AP, Doble BW, Marnellos G, Adams C, Wang Y, Phiel CJ. Glycogen synthase kinase-3 (Gsk-3) plays a fundamental role in maintaining DNA methylation at imprinted loci in mouse embryonic stem cells. Molecular Biology of the Cell. 26: 2139-50. PMID 25833708 DOI: 10.1091/Mbc.E15-01-0013  1
2014 Bartman CM, Egelston J, Kattula S, Zeidner LC, D'Ippolito A, Doble BW, Phiel CJ. Gene Expression Profiling in Mouse Embryonic Stem Cells Reveals Glycogen Synthase Kinase-3-Dependent Targets of Phosphatidylinositol 3-Kinase and Wnt/β-Catenin Signaling Pathways. Frontiers in Endocrinology. 5: 133. PMID 25165462 DOI: 10.3389/Fendo.2014.00133  1
2013 Holowacz T, Alexson TO, Coles BL, Doble BW, Kelly KF, Woodgett JR, Van Der Kooy D. The responses of neural stem cells to the level of GSK-3 depend on the tissue of origin. Biology Open. 2: 812-21. PMID 23951407 DOI: 10.1242/Bio.20131941  1
2013 Mahendram S, Kelly KF, Paez-Parent S, Mahmood S, Polena E, Cooney AJ, Doble BW. Ectopic γ-catenin expression partially mimics the effects of stabilized β-catenin on embryonic stem cell differentiation. Plos One. 8: e65320. PMID 23724138 DOI: 10.1371/Journal.Pone.0065320  1
2013 Manoranjan B, Venugopal C, McFarlane N, Doble BW, Dunn SE, Scheinemann K, Singh SK. Medulloblastoma stem cells: modeling tumor heterogeneity. Cancer Letters. 338: 23-31. PMID 22796365 DOI: 10.1016/J.Canlet.2012.07.010  1
2012 Manoranjan B, Venugopal C, McFarlane N, Doble BW, Dunn SE, Scheinemann K, Singh SK. Medulloblastoma stem cells: where development and cancer cross pathways. Pediatric Research. 71: 516-22. PMID 22430388 DOI: 10.1038/Pr.2011.62  1
2011 Kelly KF, Ng DY, Jayakumaran G, Wood GA, Koide H, Doble BW. β-catenin enhances Oct-4 activity and reinforces pluripotency through a TCF-independent mechanism. Cell Stem Cell. 8: 214-27. PMID 21295277 DOI: 10.1016/J.Stem.2010.12.010  1
2010 Popkie AP, Zeidner LC, Albrecht AM, D'Ippolito A, Eckardt S, Newsom DE, Groden J, Doble BW, Aronow B, McLaughlin KJ, White P, Phiel CJ. Phosphatidylinositol 3-kinase (PI3K) signaling via glycogen synthase kinase-3 (Gsk-3) regulates DNA methylation of imprinted loci. The Journal of Biological Chemistry. 285: 41337-47. PMID 21047779 DOI: 10.1074/Jbc.M110.170704  1
2010 Zhou J, Lal H, Chen X, Shang X, Song J, Li Y, Kerkela R, Doble BW, MacAulay K, DeCaul M, Koch WJ, Farber J, Woodgett J, Gao E, Force T. GSK-3α directly regulates β-adrenergic signaling and the response of the heart to hemodynamic stress in mice Journal of Clinical Investigation. 120: 2280-2291. PMID 20516643 DOI: 10.1172/Jci41407  1
2009 Kaidanovich-Beilin O, Lipina TV, Takao K, van Eede M, Hattori S, Laliberté C, Khan M, Okamoto K, Chambers JW, Fletcher PJ, MacAulay K, Doble BW, Henkelman M, Miyakawa T, Roder J, et al. Abnormalities in brain structure and behavior in GSK-3alpha mutant mice. Molecular Brain. 2: 35. PMID 19925672 DOI: 10.1186/1756-6606-2-35  1
2009 Kim WY, Wang X, Wu Y, Doble BW, Patel S, Woodgett JR, Snider WD. GSK-3 is a master regulator of neural progenitor homeostasis. Nature Neuroscience. 12: 1390-7. PMID 19801986 DOI: 10.1038/Nn.2408  1
2009 Doble BW, Woodgett JR. Exploring pluripotency with chemical genetics. Cell Stem Cell. 4: 98-100. PMID 19200796 DOI: 10.1016/J.Stem.2009.01.005  1
2008 Kerkela R, Kockeritz L, Macaulay K, Zhou J, Doble BW, Beahm C, Greytak S, Woulfe K, Trivedi CM, Woodgett JR, Epstein JA, Force T, Huggins GS. Deletion of GSK-3beta in mice leads to hypertrophic cardiomyopathy secondary to cardiomyoblast hyperproliferation. The Journal of Clinical Investigation. 118: 3609-18. PMID 18830417 DOI: 10.1172/Jci36245  1
2008 Patel S, Doble BW, MacAulay K, Sinclair EM, Drucker DJ, Woodgett JR. Tissue-specific role of glycogen synthase kinase 3beta in glucose homeostasis and insulin action. Molecular and Cellular Biology. 28: 6314-28. PMID 18694957 DOI: 10.1128/Mcb.00763-08  1
2008 Ying QL, Wray J, Nichols J, Batlle-Morera L, Doble B, Woodgett J, Cohen P, Smith A. The ground state of embryonic stem cell self-renewal. Nature. 453: 519-23. PMID 18497825 DOI: 10.1038/Nature06968  1
2008 Thornton TM, Pedraza-Alva G, Deng B, Wood CD, Aronshtam A, Clements JL, Sabio G, Davis RJ, Matthews DE, Doble B, Rincon M. Phosphorylation by p38 MAPK as an alternative pathway for GSK3β inactivation Science. 320: 667-670. PMID 18451303 DOI: 10.1126/Science.1156037  1
2008 Tanabe K, Liu Z, Patel S, Doble BW, Li L, Cras-Méneur C, Martinez SC, Welling CM, White MF, Bernal-Mizrachi E, Woodgett JR, Permutt MA. Genetic deficiency of glycogen synthase kinase-3beta corrects diabetes in mouse models of insulin resistance. Plos Biology. 6: e37. PMID 18288891 DOI: 10.1371/Journal.Pbio.0060037  1
2007 MacAulay K, Doble BW, Patel S, Hansotia T, Sinclair EM, Drucker DJ, Nagy A, Woodgett JR. Glycogen synthase kinase 3alpha-specific regulation of murine hepatic glycogen metabolism. Cell Metabolism. 6: 329-37. PMID 17908561 DOI: 10.1016/J.Cmet.2007.08.013  1
2007 Doble BW, Woodgett JR. Role of glycogen synthase kinase-3 in cell fate and epithelial-mesenchymal transitions. Cells, Tissues, Organs. 185: 73-84. PMID 17587811 DOI: 10.1159/000101306  1
2007 Doble BW, Patel S, Wood GA, Kockeritz LK, Woodgett JR. Functional redundancy of GSK-3alpha and GSK-3beta in Wnt/beta-catenin signaling shown by using an allelic series of embryonic stem cell lines. Developmental Cell. 12: 957-71. PMID 17543867 DOI: 10.1016/J.Devcel.2007.04.001  1
2006 Kockeritz L, Doble B, Patel S, Woodgett JR. Glycogen synthase kinase-3--an overview of an over-achieving protein kinase. Current Drug Targets. 7: 1377-88. PMID 17100578 DOI: 10.2174/1389450110607011377  1
2004 Sheikh F, Hirst CJ, Jin Y, Bock ME, Fandrich RR, Nickel BE, Doble BW, Kardami E, Cattini PA. Inhibition of TGFbeta signaling potentiates the FGF-2-induced stimulation of cardiomyocyte DNA synthesis. Cardiovascular Research. 64: 516-25. PMID 15537505 DOI: 10.1016/J.Cardiores.2004.08.009  1
2004 Patel S, Doble B, Woodgett JR. Glycogen synthase kinase-3 in insulin and Wnt signalling: A double-edged sword? Biochemical Society Transactions. 32: 803-808. PMID 15494020 DOI: 10.1042/Bst0320803  1
2004 Doble BW, Dang X, Ping P, Fandrich RR, Nickel BE, Jin Y, Cattini PA, Kardami E. Phosphorylation of serine 262 in the gap junction protein connexin-43 regulates DNA synthesis in cell-cell contact forming cardiomyocytes. Journal of Cell Science. 117: 507-14. PMID 14702389 DOI: 10.1242/Jcs.00889  1
2003 Kardami E, Banerji S, Doble BW, Dang X, Fandrich RR, Jin Y, Cattini PA. PKC-dependent phosphorylation may regulate the ability of connexin43 to inhibit DNA synthesis. Cell Communication & Adhesion. 10: 293-7. PMID 14681031 DOI: 10.1080/Cac.10.4-6.293.297  1
2003 Dang X, Doble BW, Kardami E. The carboxy-tail of connexin-43 localizes to the nucleus and inhibits cell growth. Molecular and Cellular Biochemistry. 242: 35-8. PMID 12619863 DOI: 10.1007/978-1-4757-4712-6_5  1
2003 Doble BW, Woodgett JR. GSK-3: tricks of the trade for a multi-tasking kinase. Journal of Cell Science. 116: 1175-86. PMID 12615961 DOI: 10.1242/Jcs.00384  1
2002 Jiang ZS, Padua RR, Ju H, Doble BW, Jin Y, Hao J, Cattini PA, Dixon IM, Kardami E. Acute protection of ischemic heart by FGF-2: involvement of FGF-2 receptors and protein kinase C. American Journal of Physiology. Heart and Circulatory Physiology. 282: H1071-80. PMID 11834506 DOI: 10.1152/Ajpheart.00290.2001  1
2001 Doble BW, Ping P, Fandrich RR, Cattini PA, Kardami E. Protein kinase C-epsilon mediates phorbol ester-induced phosphorylation of connexin-43. Cell Communication & Adhesion. 8: 253-6. PMID 12064598 DOI: 10.3109/15419060109080733  1
2001 Sun G, Doble BW, Sun JM, Fandrich RR, Florkiewicz R, Kirshenbaum L, Davie JR, Cattini PA, Kardami E. CUG-initiated FGF-2 induces chromatin compaction in cultured cardiac myocytes and in vitro. Journal of Cellular Physiology. 186: 457-67. PMID 11169985 DOI: 10.1002/1097-4652(2000)9999:999<000::Aid-Jcp1044>3.0.Co;2-2  1
2000 Doble BW, Ping P, Kardami E. The epsilon subtype of protein kinase C is required for cardiomyocyte connexin-43 phosphorylation. Circulation Research. 86: 293-301. PMID 10679481 DOI: 10.1161/01.Res.86.3.293  1
1998 Kardami E, Doble BW. Cardiomyocyte gap junctions: a target of growth-promoting signaling. Trends in Cardiovascular Medicine. 8: 180-7. PMID 21235931 DOI: 10.1016/S1050-1738(98)00007-3  1
1998 Padua RR, Merle PL, Doble BW, Yu CH, Zahradka P, Pierce GN, Panagia V, Kardami E. FGF-2-induced negative inotropism and cardioprotection are inhibited by chelerythrine: involvement of sarcolemmal calcium-independent protein kinase C. Journal of Molecular and Cellular Cardiology. 30: 2695-709. PMID 9990540 DOI: 10.1006/Jmcc.1998.0832  1
1997 Nagy JI, Li WE, Roy C, Doble BW, Gilchrist JS, Kardami E, Hertzberg EL. Selective monoclonal antibody recognition and cellular localization of an unphosphorylated form of connexin43. Experimental Cell Research. 236: 127-36. PMID 9344592 DOI: 10.1006/Excr.1997.3716  1
1996 Doble BW, Chen Y, Bosc DG, Litchfield DW, Kardami E. Fibroblast growth factor-2 decreases metabolic coupling and stimulates phosphorylation as well as masking of connexin43 epitopes in cardiac myocytes. Circulation Research. 79: 647-58. PMID 8831488 DOI: 10.1161/01.Res.79.4.647  1
1995 Doble BW, Kardami E. Basic fibroblast growth factor stimulates connexin-43 expression and intercellular communication of cardiac fibroblasts. Molecular and Cellular Biochemistry. 143: 81-7. PMID 7776963 DOI: 10.1007/Bf00925930  1
1995 Kardami E, Liu L, Pasumarthi SK, Doble BW, Cattini PA. Regulation of basic fibroblast growth factor (bFGF) and FGF receptors in the heart. Annals of the New York Academy of Sciences. 752: 353-69. PMID 7755280 DOI: 10.1111/J.1749-6632.1995.Tb17444.X  1
1994 Pasumarthi KB, Doble BW, Kardami E, Cattini PA. Over-expression of CUG- or AUG-initiated forms of basic fibroblast growth factor in cardiac myocytes results in similar effects on mitosis and protein synthesis but distinct nuclear morphologies. Journal of Molecular and Cellular Cardiology. 26: 1045-60. PMID 7799445 DOI: 10.1006/Jmcc.1994.1125  1
1993 Liu L, Doble BW, Kardami E. Perinatal phenotype and hypothyroidism are associated with elevated levels of 21.5- to 22-kDa basic fibroblast growth factor in cardiac ventricles. Developmental Biology. 157: 507-16. PMID 8500657 DOI: 10.1006/Dbio.1993.1153  1
1993 Kardami E, Padua RR, Pasumarthi KBS, Liu L, Doble BW, Davey SE, Cattini PA. Basic fibroblast growth factor in cardiac myocytes: expression and effects Developments in Cardiovascular Medicine. 147: 55-75. DOI: 10.1007/978-1-4615-3098-5_5  1
1991 Kardami E, Stoski RM, Doble BW, Yamamoto T, Hertzberg EL, Nagy JI. Biochemical and ultrastructural evidence for the association of basic fibroblast growth factor with cardiac gap junctions. The Journal of Biological Chemistry. 266: 19551-7. PMID 1918064  1
1991 Kardami E, Liu L, Doble BW. Basic fibroblast growth factor in cultured cardiac myocytes. Annals of the New York Academy of Sciences. 638: 244-55. PMID 1785804 DOI: 10.1111/J.1749-6632.1991.Tb49035.X  1
1990 Doble BW, Fandrich RR, Liu L, Padua RR, Kardami E. Calcium protects pituitary basic fibroblast growth factors from limited proteolysis by co-purifying proteases. Biochemical and Biophysical Research Communications. 173: 1116-22. PMID 2268315 DOI: 10.1016/S0006-291X(05)80901-5  1
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