William B. Guggino - Publications

Affiliations: 
Johns Hopkins University, Baltimore, MD 
Area:
Cell Biology

106 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Yanda MK, Guggino WB, Cebotaru L. A new role for heat shock factor 27 in the pathophysiology of Clostridium difficile toxin B. American Journal of Physiology. Gastrointestinal and Liver Physiology. PMID 31709831 DOI: 10.1152/ajpgi.00166.2019  0.76
2019 Bergbower EAS, Sabirzhanova I, Boinot C, Guggino WB, Cebotaru L. Restoration of F508-del Function by Transcomplementation: The Partners Meet in the Endoplasmic Reticulum. Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology. 52: 1267-1279. PMID 31026390 DOI: 10.33594/000000089  0.76
2018 Sabirzhanova I, Boinot C, Guggino WB, Cebotaru L. Syntaxin 8 and the Endoplasmic Reticulum Processing of ΔF508-CFTR. Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology. 51: 1489-1499. PMID 30485852 DOI: 10.1159/000495596  0.76
2018 Yanda MK, Liu Q, Cebotaru V, Guggino WB, Cebotaru L. Role of calcium in adult onset polycystic kidney disease. Cellular Signalling. PMID 30296477 DOI: 10.1016/j.cellsig.2018.10.003  0.76
2018 Liu Q, Sabirzhanova I, Yanda MK, Bergbower EAS, Boinot C, Guggino WB, Cebotaru L. Rescue of CFTR NBD2 mutants N1303K and S1235R is influenced by the functioning of the autophagosome. Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society. PMID 29936070 DOI: 10.1016/j.jcf.2018.05.016  0.76
2017 Yanda MK, Liu Q, Cebotaru V, Guggino WB, Cebotaru L. Histone deacetylase 6 Inhibition reduces cysts by decreasing via cAMP and Ca2+ in knockout mouse models of polycystic kidney disease. The Journal of Biological Chemistry. PMID 28887310 DOI: 10.1074/jbc.M117.803775  0.76
2017 Guggino W, Benson J, Seagrave J, Yan Z, Engelhardt JF, Gao G, Conlon TJ, Cebotaru L. A PRECLINICAL STUDY IN RHESUS MACAQUES FOR CYSTIC FIBROSIS TO ASSESS GENE TRANSFER AND TRANSDUCTION BY AAV1 AND AAV5 WITH A DUAL-LUCIFERASE REPORTER SYSTEM. Human Gene Therapy. Clinical Development. PMID 28726496 DOI: 10.1089/humc.2017.067  0.76
2017 Guggino WB, Cebotaru L. Adeno-Associated Virus (AAV) gene therapy for cystic fibrosis: current barriers and recent developments. Expert Opinion On Biological Therapy. PMID 28657358 DOI: 10.1080/14712598.2017.1347630  0.76
2016 Wang H, Cebotaru L, Lee HW, Yang Q, Pollard BS, Pollard HB, Guggino WB. CFTR Controls the Activity of NF-κB by Enhancing the Degradation of TRADD. Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology. 40: 1063-1078. PMID 27960153 DOI: 10.1159/000453162  0.88
2016 Cebotaru L, Cebotaru V, Wang H, Arend LJ, Guggino WB. STIM1fl/fl Ksp-Cre Mouse has Impaired Renal Water Balance. Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology. 39: 172-182. PMID 27336410 DOI: 10.1159/000445614  0.88
2016 Cebotaru L, Liu Q, Yanda M, Boinot C, Outeda P, Huso DL, Watnick T, Guggino WB, Cebotaru V. Inhibition of histone deacetylase 6 activity reduces cyst growth in polycystic kidney disease. Kidney International. PMID 27165822 DOI: 10.1016/j.kint.2016.01.026  0.76
2016 Lopes-Pacheco M, Sabirzhanova I, Rapino D, Morales MM, Guggino WB, Cebotaru L. Correctors rescue CFTR mutations in nucleotide-binding domain 1 (NBD1) by modulating proteostasis. Chembiochem : a European Journal of Chemical Biology. PMID 26864378 DOI: 10.1002/cbic.201500620  0.76
2016 Veit G, Avramescu RG, Chiang AN, Houck SA, Cai Z, Peters KW, Hong JS, Pollard HB, Guggino WB, Balch WE, Skach WR, Cutting GR, Frizzell RA, Sheppard DN, Cyr DM, et al. From CFTR biology toward combinatorial pharmacotherapy: expanded classification of cystic fibrosis mutations. Molecular Biology of the Cell. 27: 424-33. PMID 26823392 DOI: 10.1091/mbc.E14-04-0935  0.52
2016 de Lemos Barbosa CM, Souza-Menezes J, Amaral AG, Onuchic LF, Cebotaru L, Guggino WB, Morales MM. Regulation of CFTR Expression and Arginine Vasopressin Activity Are Dependent on Polycystin-1 in Kidney-Derived Cells. Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology. 38: 28-39. PMID 26741910 DOI: 10.1159/000438606  0.76
2015 Lopes-Pacheco M, Boinot C, Sabirzhanova I, Morales MM, Guggino WB, Cebotaru L. Combination of correctors rescue ΔF508-CFTR by reducing its association with Hsp 40 and 27. The Journal of Biological Chemistry. PMID 26336106 DOI: 10.1074/jbc.M115.671925  0.96
2015 Sabirzhanova I, Lopes Pacheco M, Rapino D, Grover R, Handa JT, Guggino WB, Cebotaru L. Rescuing Trafficking Mutants of the ATP-binding Cassette Protein, ABCA4, with Small Molecule Correctors as a Treatment for Stargardt Eye Disease. The Journal of Biological Chemistry. 290: 19743-55. PMID 26092729 DOI: 10.1074/jbc.M115.647685  0.76
2015 Rapino D, Sabirzhanova I, Lopes-Pacheco M, Grover R, Guggino WB, Cebotaru L. Rescue of NBD2 mutants N1303K and S1235R of CFTR by small-molecule correctors and transcomplementation. Plos One. 10: e0119796. PMID 25799511 DOI: 10.1371/journal.pone.0119796  0.96
2014 Cebotaru L, Guggino WB. Complement yourself: Transcomplementation rescues partially folded mutant proteins. Biophysical Reviews. 6: 169-180. PMID 24949105 DOI: 10.1007/s12551-014-0137-3  0.76
2014 Schuster BS, Kim AJ, Kays JC, Kanzawa MM, Guggino WB, Boyle MP, Rowe SM, Muzyczka N, Suk JS, Hanes J. Overcoming the cystic fibrosis sputum barrier to leading adeno-associated virus gene therapy vectors. Molecular Therapy : the Journal of the American Society of Gene Therapy. 22: 1484-93. PMID 24869933 DOI: 10.1038/mt.2014.89  0.96
2014 Peruchetti DB, Cheng J, Caruso-Neves C, Guggino WB. Mis-regulation of mammalian target of rapamycin (mTOR) complexes induced by albuminuria in proximal tubules. The Journal of Biological Chemistry. 289: 16790-801. PMID 24790108 DOI: 10.1074/jbc.M114.549717  0.88
2014 Cebotaru V, Cebotaru L, Kim H, Chiaravalli M, Boletta A, Qian F, Guggino WB. Polycystin-1 negatively regulates Polycystin-2 expression via the aggresome/autophagosome pathway. The Journal of Biological Chemistry. 289: 6404-14. PMID 24459142 DOI: 10.1074/jbc.M113.501205  0.72
2014 Suk JS, Kim AJ, Trehan K, Schneider CS, Cebotaru L, Woodward OM, Boylan NJ, Boyle MP, Lai SK, Guggino WB, Hanes J. Lung gene therapy with highly compacted DNA nanoparticles that overcome the mucus barrier. Journal of Controlled Release : Official Journal of the Controlled Release Society. 178: 8-17. PMID 24440664 DOI: 10.1016/j.jconrel.2014.01.007  0.96
2014 Cebotaru L, Rapino D, Cebotaru V, Guggino WB. Correcting the cystic fibrosis disease mutant, A455E CFTR. Plos One. 9: e85183. PMID 24416359 DOI: 10.1371/journal.pone.0085183  0.76
2013 Lee HW, Cheng J, Kovbasnjuk O, Donowitz M, Guggino WB. Insulin-like growth factor 1 (IGF-1) enhances the protein expression of CFTR. Plos One. 8: e59992. PMID 23555857 DOI: 10.1371/journal.pone.0059992  0.96
2013 Woodward OM, Tukaye DN, Cui J, Greenwell P, Constantoulakis LM, Parker BS, Rao A, Köttgen M, Maloney PC, Guggino WB. Gout-causing Q141K mutation in ABCG2 leads to instability of the nucleotide-binding domain and can be corrected with small molecules. Proceedings of the National Academy of Sciences of the United States of America. 110: 5223-8. PMID 23493553 DOI: 10.1073/pnas.1214530110  0.96
2013 Cebotaru L, Woodward O, Cebotaru V, Guggino WB. Transcomplementation by a truncation mutant of cystic fibrosis transmembrane conductance regulator (CFTR) EnhancesδF508 processing through a biomolecular interaction Journal of Biological Chemistry. 288: 10505-10512. PMID 23463513 DOI: 10.1074/jbc.M112.420489  0.96
2013 Tukaye DN, Kwon SH, Guggino WB. The GAP portion of Pseudomonas aeruginosa type III secreted toxin ExoS upregulates total and surface levels of wild type CFTR. Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology. 31: 153-65. PMID 23428533 DOI: 10.1159/000343357  0.96
2012 Prota LF, Cebotaru L, Cheng J, Wright J, Vij N, Morales MM, Guggino WB. Dexamethasone regulates CFTR expression in Calu-3 cells with the involvement of chaperones HSP70 and HSP90. Plos One. 7: e47405. PMID 23272037 DOI: 10.1371/journal.pone.0047405  0.88
2012 Ramsey BW, Banks-Schlegel S, Accurso FJ, Boucher RC, Cutting GR, Engelhardt JF, Guggino WB, Karp CL, Knowles MR, Kolls JK, LiPuma JJ, Lynch S, McCray PB, Rubenstein RC, Singh PK, et al. Future directions in early cystic fibrosis lung disease research: an NHLBI workshop report. American Journal of Respiratory and Critical Care Medicine. 185: 887-92. PMID 22312017 DOI: 10.1164/rccm.201111-2068WS  0.96
2011 Peruchetti DB, Pinheiro AA, Landgraf SS, Wengert M, Takiya CM, Guggino WB, Caruso-Neves C. (Na+ + K+)-ATPase is a target for phosphoinositide 3-kinase/protein kinase B and protein kinase C pathways triggered by albumin. The Journal of Biological Chemistry. 286: 45041-7. PMID 22057272 DOI: 10.1074/jbc.M111.260737  0.44
2011 Liang L, Woodward OM, Chen Z, Cotter R, Guggino WB. A novel role of protein tyrosine kinase2 in mediating chloride secretion in human airway epithelial cells. Plos One. 6: e21991. PMID 21765932 DOI: 10.1371/journal.pone.0021991  0.96
2011 Santoso NG, Cebotaru L, Guggino WB. Polycystin-1, 2, and STIM1 interact with IP(3)R to modulate ER Ca release through the PI3K/Akt pathway. Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology. 27: 715-26. PMID 21691089 DOI: 10.1159/000330080  0.76
2011 Bomberger JM, Guggino WB, Stanton BA. Methods to monitor cell surface expression and endocytic trafficking of CFTR in polarized epithelial cells. Methods in Molecular Biology (Clifton, N.J.). 741: 271-83. PMID 21594791 DOI: 10.1007/978-1-61779-117-8_18  0.44
2011 Peters KW, Okiyoneda T, Balch WE, Braakman I, Brodsky JL, Guggino WB, Penland CM, Pollard HB, Sorscher EJ, Skach WR, Thomas PJ, Lukacs GL, Frizzell RA. CFTR Folding Consortium: methods available for studies of CFTR folding and correction. Methods in Molecular Biology (Clifton, N.J.). 742: 335-53. PMID 21547742 DOI: 10.1007/978-1-61779-120-8_20  0.96
2010 Lassance-Soares RM, Cheng J, Krasnov K, Cebotaru L, Cutting GR, Souza-Menezes J, Morales MM, Guggino WB. The hypertonic environment differentially regulates wild-type CFTR and TNR-CFTR chloride channels. Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology. 26: 577-86. PMID 21063095 DOI: 10.1159/000322325  0.88
2010 Woodward OM, Li Y, Yu S, Greenwell P, Wodarczyk C, Boletta A, Guggino WB, Qian F. Identification of a polycystin-1 cleavage product, P100, that regulates store operated Ca entry through interactions with STIM1. Plos One. 5: e12305. PMID 20808796 DOI: 10.1371/journal.pone.0012305  0.96
2010 Kwon Y, Kim SH, Ronderos DS, Lee Y, Akitake B, Woodward OM, Guggino WB, Smith DP, Montell C. Drosophila TRPA1 channel is required to avoid the naturally occurring insect repellent citronellal. Current Biology : Cb. 20: 1672-8. PMID 20797863 DOI: 10.1016/j.cub.2010.08.016  0.96
2010 Kim SH, Lee Y, Akitake B, Woodward OM, Guggino WB, Montell C. Drosophila TRPA1 channel mediates chemical avoidance in gustatory receptor neurons. Proceedings of the National Academy of Sciences of the United States of America. 107: 8440-5. PMID 20404155 DOI: 10.1073/pnas.1001425107  0.96
2010 Atwell S, Brouillette CG, Conners K, Emtage S, Gheyi T, Guggino WB, Hendle J, Hunt JF, Lewis HA, Lu F, Protasevich II, Rodgers LA, Romero R, Wasserman SR, Weber PC, et al. Structures of a minimal human CFTR first nucleotide-binding domain as a monomer, head-to-tail homodimer, and pathogenic mutant. Protein Engineering, Design & Selection : Peds. 23: 375-84. PMID 20150177 DOI: 10.1093/protein/gzq004  0.96
2010 Cheng J, Cebotaru V, Cebotaru L, Guggino WB. Syntaxin 6 and CAL mediate the degradation of the cystic fibrosis transmembrane conductance regulator. Molecular Biology of the Cell. 21: 1178-87. PMID 20130090 DOI: 10.1091/mbc.E09-03-0229  0.88
2010 Hoque KM, Woodward OM, van Rossum DB, Zachos NC, Chen L, Leung GP, Guggino WB, Guggino SE, Tse CM. Epac1 mediates protein kinase A-independent mechanism of forskolin-activated intestinal chloride secretion. The Journal of General Physiology. 135: 43-58. PMID 20038525 DOI: 10.1085/jgp.200910339  0.96
2010 Zhou B, Zhuang J, Gu D, Wang H, Cebotaru L, Guggino WB, Cai H. WNK4 enhances the degradation of NCC through a sortilin-mediated lysosomal pathway. Journal of the American Society of Nephrology : Jasn. 21: 82-92. PMID 19875813 DOI: 10.1681/ASN.2008121275  0.88
2010 Flotte TR, Fischer AC, Goetzmann J, Mueller C, Cebotaru L, Yan Z, Wang L, Wilson JM, Guggino WB, Engelhardt JF. Dual reporter comparative indexing of rAAV pseudotyped vectors in chimpanzee airway. Molecular Therapy : the Journal of the American Society of Gene Therapy. 18: 594-600. PMID 19826405 DOI: 10.1038/mt.2009.230  0.96
2009 Li Y, Santoso NG, Yu S, Woodward OM, Qian F, Guggino WB. Polycystin-1 interacts with inositol 1,4,5-trisphosphate receptor to modulate intracellular Ca2+ signaling with implications for polycystic kidney disease. The Journal of Biological Chemistry. 284: 36431-41. PMID 19854836 DOI: 10.1074/jbc.M109.068916  0.96
2009 Woodward OM, Köttgen A, Coresh J, Boerwinkle E, Guggino WB, Köttgen M. Identification of a urate transporter, ABCG2, with a common functional polymorphism causing gout. Proceedings of the National Academy of Sciences of the United States of America. 106: 10338-42. PMID 19506252 DOI: 10.1073/pnas.0901249106  0.96
2009 Fan C, Su Q, Li Y, Liang L, Angelini DJ, Guggino WB, Johns RA. Hypoxia-induced mitogenic factor/FIZZ1 induces intracellular calcium release through the PLC-IP(3) pathway. American Journal of Physiology. Lung Cellular and Molecular Physiology. 297: L263-70. PMID 19429774 DOI: 10.1152/ajplung.90416.2008  0.48
2009 Liang L, MacDonald K, Schwiebert EM, Zeitlin PL, Guggino WB. Spiperone, identified through compound screening, activates calcium-dependent chloride secretion in the airway. American Journal of Physiology. Cell Physiology. 296: C131-41. PMID 18987251 DOI: 10.1152/ajpcell.00346.2008  0.96
2008 Krasnov KV, Tzetis M, Cheng J, Guggino WB, Cutting GR. Localization studies of rare missense mutations in cystic fibrosis transmembrane conductance regulator (CFTR) facilitate interpretation of genotype-phenotype relationships. Human Mutation. 29: 1364-72. PMID 18951463 DOI: 10.1002/humu.20866  0.88
2008 Souza-Menezes J, Tukaye DN, Novaira HJ, Guggino WB, Morales MM. Small nuclear RNAs U11 and U12 modulate expression of TNR-CFTR mRNA in mammalian kidneys. Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology. 22: 93-100. PMID 18769035 DOI: 10.1159/000149786  0.96
2008 Wright J, Morales MM, Sousa-Menzes J, Ornellas D, Sipes J, Cui Y, Cui I, Hulamm P, Cebotaru V, Cebotaru L, Guggino WB, Guggino SE. Transcriptional adaptation to Clcn5 knockout in proximal tubules of mouse kidney. Physiological Genomics. 33: 341-54. PMID 18349385 DOI: 10.1152/physiolgenomics.00024.2008  0.96
2008 Lassance RM, Pássaro CP, Martini SV, Castiglione RC, Gutierrez TM, Abreu SC, Antunes MA, Xisto DG, Cebotaru L, Petrs-Silva H, Zin WA, Guggino WB, Linden R, Rocco PR, Morales MM. Does the use of recombinant AAV2 in pulmonary gene therapy damage lung function? Respiratory Physiology & Neurobiology. 160: 91-8. PMID 17950048 DOI: 10.1016/j.resp.2007.09.002  0.96
2007 Pollard HB, Srivastava M, Eidelman O, Jozwik C, Rothwell SW, Mueller GP, Jacobowitz DM, Darling T, Guggino WB, Wright J, Zeitlin PL, Paweletz CP. Protein microarray platforms for clinical proteomics. Proteomics. Clinical Applications. 1: 934-52. PMID 21136748 DOI: 10.1002/prca.200700154  0.96
2007 Kwon SH, Pollard H, Guggino WB. Knockdown of NHERF1 enhances degradation of temperature rescued DeltaF508 CFTR from the cell surface of human airway cells. Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology. 20: 763-72. PMID 17982258 DOI: 10.1159/000110436  0.96
2007 Souza-Menezes J, Morales MM, Tukaye DN, Guggino SE, Guggino WB. Absence of ClC5 in knockout mice leads to glycosuria, impaired renal glucose handling and low proximal tubule GLUT2 protein expression. Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology. 20: 455-64. PMID 17762172 DOI: 10.1159/000107529  0.96
2007 Liu X, Luo M, Trygg C, Yan Z, Lei-Butters DC, Smith CI, Fischer AC, Munson K, Guggino WB, Bunnell BA, Engelhardt JF. Biological Differences in rAAV Transduction of Airway Epithelia in Humans and in Old World Non-human Primates. Molecular Therapy : the Journal of the American Society of Gene Therapy. 15: 2114-23. PMID 17667945 DOI: 10.1038/sj.mt.6300277  0.96
2007 Fischer AC, Smith CI, Cebotaru L, Zhang X, Askin FB, Wright J, Guggino SE, Adams RJ, Flotte T, Guggino WB. Expression of a truncated cystic fibrosis transmembrane conductance regulator with an AAV5-pseudotyped vector in primates. Molecular Therapy : the Journal of the American Society of Gene Therapy. 15: 756-63. PMID 17299412 DOI: 10.1038/sj.mt.6300059  0.96
2007 Wolde M, Fellows A, Cheng J, Kivenson A, Coutermarsh B, Talebian L, Karlson K, Piserchio A, Mierke DF, Stanton BA, Guggino WB, Madden DR. Targeting CAL as a negative regulator of DeltaF508-CFTR cell-surface expression: an RNA interference and structure-based mutagenetic approach. The Journal of Biological Chemistry. 282: 8099-109. PMID 17158866 DOI: 10.1074/jbc.M611049200  0.96
2006 Caruso-Neves C, Pinheiro AA, Cai H, Souza-Menezes J, Guggino WB. PKB and megalin determine the survival or death of renal proximal tubule cells. Proceedings of the National Academy of Sciences of the United States of America. 103: 18810-5. PMID 17121993 DOI: 10.1073/pnas.0605029103  0.68
2006 Ikeda M, Fong P, Cheng J, Boletta A, Qian F, Zhang XM, Cai H, Germino GG, Guggino WB. A regulatory role of polycystin-1 on cystic fibrosis transmembrane conductance regulator plasma membrane expression. Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology. 18: 9-20. PMID 16914886 DOI: 10.1159/000095133  0.96
2006 Pollard HB, Eidelman O, Jozwik C, Huang W, Srivastava M, Ji XD, McGowan B, Norris CF, Todo T, Darling T, Mogayzel PJ, Zeitlin PL, Wright J, Guggino WB, Metcalf E, et al. De novo biosynthetic profiling of high abundance proteins in cystic fibrosis lung epithelial cells. Molecular & Cellular Proteomics : McP. 5: 1628-37. PMID 16829594 DOI: 10.1074/mcp.M600091-MCP200  0.96
2006 Guggino WB, Stanton BA. New insights into cystic fibrosis: molecular switches that regulate CFTR. Nature Reviews. Molecular Cell Biology. 7: 426-36. PMID 16723978 DOI: 10.1038/nrm1949  0.44
2006 Cai H, Cebotaru V, Wang YH, Zhang XM, Cebotaru L, Guggino SE, Guggino WB. WNK4 kinase regulates surface expression of the human sodium chloride cotransporter in mammalian cells. Kidney International. 69: 2162-70. PMID 16688122 DOI: 10.1038/sj.ki.5000333  0.96
2006 Boyle MP, Enke RA, Reynolds JB, Mogayzel PJ, Guggino WB, Zeitlin PL. Membrane-associated heparan sulfate is not required for rAAV-2 infection of human respiratory epithelia. Virology Journal. 3: 29. PMID 16630361 DOI: 10.1186/1743-422X-3-29  0.96
2006 Wright JM, Merlo CA, Reynolds JB, Zeitlin PL, Garcia JG, Guggino WB, Boyle MP. Respiratory epithelial gene expression in patients with mild and severe cystic fibrosis lung disease. American Journal of Respiratory Cell and Molecular Biology. 35: 327-36. PMID 16614352 DOI: 10.1165/rcmb.2005-0359OC  0.96
2006 van den Hove MF, Croizet-Berger K, Jouret F, Guggino SE, Guggino WB, Devuyst O, Courtoy PJ. The loss of the chloride channel, ClC-5, delays apical iodide efflux and induces a euthyroid goiter in the mouse thyroid gland. Endocrinology. 147: 1287-96. PMID 16306076 DOI: 10.1210/en.2005-1149  0.96
2006 Beitz E, Liu K, Ikeda M, Guggino WB, Agre P, Yasui M. Determinants of AQP6 trafficking to intracellular sites versus the plasma membrane in transfected mammalian cells. Biology of the Cell / Under the Auspices of the European Cell Biology Organization. 98: 101-9. PMID 15892693 DOI: 10.1042/BC20050025  0.44
2005 Caruso-Neves C, Kwon SH, Guggino WB. Albumin endocytosis in proximal tubule cells is modulated by angiotensin II through an AT2 receptor-mediated protein kinase B activation. Proceedings of the National Academy of Sciences of the United States of America. 102: 17513-8. PMID 16293694 DOI: 10.1073/pnas.0507255102  0.96
2005 Li Y, Wright JM, Qian F, Germino GG, Guggino WB. Polycystin 2 interacts with type I inositol 1,4,5-trisphosphate receptor to modulate intracellular Ca2+ signaling. The Journal of Biological Chemistry. 280: 41298-306. PMID 16223735 DOI: 10.1074/jbc.M510082200  0.48
2005 Flotte TR, Schwiebert EM, Zeitlin PL, Carter BJ, Guggino WB. Correlation between DNA transfer and cystic fibrosis airway epithelial cell correction after recombinant adeno-associated virus serotype 2 gene therapy. Human Gene Therapy. 16: 921-8. PMID 16076250 DOI: 10.1089/hum.2005.16.921  0.96
2005 Cebotaru V, Kaul S, Devuyst O, Cai H, Racusen L, Guggino WB, Guggino SE. High citrate diet delays progression of renal insufficiency in the ClC-5 knockout mouse model of Dent's disease. Kidney International. 68: 642-52. PMID 16014041 DOI: 10.1111/j.1523-1755.2005.00442.x  0.96
2005 Wang Y, Cai H, Cebotaru L, Hryciw DH, Weinman EJ, Donowitz M, Guggino SE, Guggino WB. ClC-5: role in endocytosis in the proximal tubule. American Journal of Physiology. Renal Physiology. 289: F850-62. PMID 15942052 DOI: 10.1152/ajprenal.00011.2005  0.96
2005 Hara-Chikuma M, Wang Y, Guggino SE, Guggino WB, Verkman AS. Impaired acidification in early endosomes of ClC-5 deficient proximal tubule. Biochemical and Biophysical Research Communications. 329: 941-6. PMID 15752747 DOI: 10.1016/j.bbrc.2005.02.060  0.96
2005 Rebelo MA, Tostes V, Araújo NC, Martini SV, Botelho BF, Guggino WB, Morales MM. Screening for CLCN5 mutation in renal calcium stone formers patients. Anais Da Academia Brasileira De CiêNcias. 77: 95-101. PMID 15692680  0.4
2005 Cheng J, Wang H, Guggino WB. Regulation of cystic fibrosis transmembrane regulator trafficking and protein expression by a Rho family small GTPase TC10. The Journal of Biological Chemistry. 280: 3731-9. PMID 15546864 DOI: 10.1074/jbc.M410026200  0.88
2005 Lewis HA, Zhao X, Wang C, Sauder JM, Rooney I, Noland BW, Lorimer D, Kearins MC, Conners K, Condon B, Maloney PC, Guggino WB, Hunt JF, Emtage S. Impact of the deltaF508 mutation in first nucleotide-binding domain of human cystic fibrosis transmembrane conductance regulator on domain folding and structure. The Journal of Biological Chemistry. 280: 1346-53. PMID 15528182 DOI: 10.1074/jbc.M410968200  0.96
2004 Hryciw DH, Ekberg J, Lee A, Lensink IL, Kumar S, Guggino WB, Cook DI, Pollock CA, Poronnik P. Nedd4-2 functionally interacts with ClC-5: involvement in constitutive albumin endocytosis in proximal tubule cells. The Journal of Biological Chemistry. 279: 54996-5007. PMID 15489223 DOI: 10.1074/jbc.M411491200  0.96
2004 Kwon SH, Guggino WB. Multiple sequences in the C terminus of MaxiK channels are involved in expression, movement to the cell surface, and apical localization. Proceedings of the National Academy of Sciences of the United States of America. 101: 15237-42. PMID 15469924 DOI: 10.1073/pnas.0404877101  0.96
2004 Sirninger J, Muller C, Braag S, Tang Q, Yue H, Detrisac C, Ferkol T, Guggino WB, Flotte TR. Functional characterization of a recombinant adeno-associated virus 5-pseudotyped cystic fibrosis transmembrane conductance regulator vector Human Gene Therapy. 15: 832-841. PMID 15353038 DOI: 10.1089/1043034041839262  0.96
2004 Karp CL, Flick LM, Park KW, Softic S, Greer TM, Keledjian R, Yang R, Uddin J, Guggino WB, Atabani SF, Belkaid Y, Xu Y, Whitsett JA, Accurso FJ, Wills-Karp M, et al. Defective lipoxin-mediated anti-inflammatory activity in the cystic fibrosis airway. Nature Immunology. 5: 388-92. PMID 15034576 DOI: 10.1038/ni1056  0.96
2004 Zeitlin PL, Boyle MP, Guggino WB, Molina L. A phase I trial of intranasal Moli1901 for cystic fibrosis. Chest. 125: 143-9. PMID 14718433 DOI: 10.1378/chest.125.1.143  0.96
2004 Lewis HA, Buchanan SG, Burley SK, Conners K, Dickey M, Dorwart M, Fowler R, Gao X, Guggino WB, Hendrickson WA, Hunt JF, Kearins MC, Lorimer D, Maloney PC, Post KW, et al. Structure of nucleotide-binding domain 1 of the cystic fibrosis transmembrane conductance regulator. The Embo Journal. 23: 282-93. PMID 14685259 DOI: 10.1038/sj.emboj.7600040  0.96
2004 Wright JM, Zeitlin PL, Cebotaru L, Guggino SE, Guggino WB. Gene expression profile analysis of 4-phenylbutyrate treatment of IB3-1 bronchial epithelial cell line demonstrates a major influence on heat-shock proteins. Physiological Genomics. 16: 204-11. PMID 14583596 DOI: 10.1152/physiolgenomics.00160.2003  0.96
2004 Cheng J, Wang H, Guggino WB. Modulation of mature cystic fibrosis transmembrane regulator protein by the PDZ domain protein CAL. The Journal of Biological Chemistry. 279: 1892-8. PMID 14570915 DOI: 10.1074/jbc.M308640200  0.88
2003 Fischer AC, Beck SE, Smith CI, Laube BL, Askin FB, Guggino SE, Adams RJ, Flotte TR, Guggino WB. Successful transgene expression with serial doses of aerosolized rAAV2 vectors in rhesus macaques. Molecular Therapy : the Journal of the American Society of Gene Therapy. 8: 918-26. PMID 14664794 DOI: 10.1016/j.ymthe.2003.08.015  0.96
2003 Hryciw DH, Wang Y, Devuyst O, Pollock CA, Poronnik P, Guggino WB. Cofilin interacts with ClC-5 and regulates albumin uptake in proximal tubule cell lines Journal of Biological Chemistry. 278: 40169-40176. PMID 12904289 DOI: 10.1074/jbc.M307890200  0.96
2003 Flotte TR, Zeitlin PL, Reynolds TC, Heald AE, Pedersen P, Beck S, Conrad CK, Brass-Ernst L, Humphries M, Sullivan K, Wetzel R, Taylor G, Carter BJ, Guggino WB. Phase I trial of intranasal and endobronchial administration of a recombinant adeno-associated virus serotype 2 (rAAV2)-CFTR vector in adult cystic fibrosis patients: a two-part clinical study. Human Gene Therapy. 14: 1079-88. PMID 12885347 DOI: 10.1089/104303403322124792  0.96
2003 Christensen EI, Devuyst O, Dom G, Nielsen R, Van der Smissen P, Verroust P, Leruth M, Guggino WB, Courtoy PJ. Loss of chloride channel ClC-5 impairs endocytosis by defective trafficking of megalin and cubilin in kidney proximal tubules. Proceedings of the National Academy of Sciences of the United States of America. 100: 8472-7. PMID 12815097 DOI: 10.1073/pnas.1432873100  0.56
2003 Nascimento DS, Reis CU, Goldenberg RC, Ortiga-Carvalho TM, Pazos-Moura CC, Guggino SE, Guggino WB, Morales MM. Estrogen modulates ClC-2 chloride channel gene expression in rat kidney. PflüGers Archiv : European Journal of Physiology. 446: 593-9. PMID 12811561 DOI: 10.1007/s00424-003-1095-y  0.96
2003 Fong P, Argent BE, Guggino WB, Gray MA. Characterization of vectorial chloride transport pathways in the human pancreatic duct adenocarcinoma cell line HPAF. American Journal of Physiology. Cell Physiology. 285: C433-45. PMID 12711595 DOI: 10.1152/ajpcell.00509.2002  0.96
2003 Silva IV, Cebotaru V, Wang H, Wang XT, Wang SS, Guo G, Devuyst O, Thakker RV, Guggino WB, Guggino SE. The ClC-5 knockout mouse model of Dent's disease has renal hypercalciuria and increased bone turnover. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. 18: 615-23. PMID 12674322 DOI: 10.1359/jbmr.2003.18.4.615  0.96
2003 Boyle MP, Enke RA, Mogayzel PJ, Guggino WB, Martin DB, Agarwal S, Zeitlin PL. Effect of adeno-associated virus-specific immunoglobulin G in human amniotic fluid on gene transfer. Human Gene Therapy. 14: 365-73. PMID 12659677 DOI: 10.1089/104303403321208961  0.96
2003 Wang SX, Ikeda M, Guggino WB. The cytoplasmic tail of large conductance, voltage- and Ca2+-activated K+ (MaxiK) channel is necessary for its cell surface expression. The Journal of Biological Chemistry. 278: 2713-22. PMID 12438308 DOI: 10.1074/jbc.M208411200  0.44
2002 Devuyst O, Guggino WB. Chloride channels in the kidney: lessons learned from knockout animals. American Journal of Physiology. Renal Physiology. 283: F1176-91. PMID 12426234 DOI: 10.1152/ajprenal.00184.2002  0.56
2002 Beck SE, Laube BL, Barberena CI, Fischer AC, Adams RJ, Chesnut K, Flotte TR, Guggino WB. Deposition and expression of aerosolized rAAV vectors in the lungs of Rhesus macaques. Molecular Therapy : the Journal of the American Society of Gene Therapy. 6: 546-54. PMID 12387250 DOI: 10.1006/mthe.2002.0698  0.96
2002 Lebeau C, Hanaoka K, Moore-Hoon ML, Guggino WB, Beauwens R, Devuyst O. Basolateral chloride transporters in autosomal dominant polycystic kidney disease. PflüGers Archiv : European Journal of Physiology. 444: 722-31. PMID 12355171 DOI: 10.1007/s00424-002-0880-3  0.56
2002 Ikeda M, Guggino WB. Do polycystins function as cation channels? Current Opinion in Nephrology and Hypertension. 11: 539-45. PMID 12187319  0.44
2002 Ikeda M, Beitz E, Kozono D, Guggino WB, Agre P, Yasui M. Characterization of aquaporin-6 as a nitrate channel in mammalian cells. Requirement of pore-lining residue threonine 63. The Journal of Biological Chemistry. 277: 39873-9. PMID 12177001 DOI: 10.1074/jbc.M207008200  0.44
2002 Swiatecka-Urban A, Duhaime M, Coutermarsh B, Karlson KH, Collawn J, Milewski M, Cutting GR, Guggino WB, Langford G, Stanton BA. PDZ domain interaction controls the endocytic recycling of the cystic fibrosis transmembrane conductance regulator. The Journal of Biological Chemistry. 277: 40099-105. PMID 12167629 DOI: 10.1074/jbc.M206964200  0.44
2002 Wagner JA, Nepomuceno IB, Messner AH, Moran ML, Batson EP, Dimiceli S, Brown BW, Desch JK, Norbash AM, Conrad CK, Guggino WB, Flotte TR, Wine JJ, Carter BJ, Reynolds TC, et al. A phase II, double-blind, randomized, placebo-controlled clinical trial of tgAAVCF using maxillary sinus delivery in patients with cystic fibrosis with antrostomies. Human Gene Therapy. 13: 1349-59. PMID 12162817 DOI: 10.1089/104303402760128577  0.96
2002 Ornellas DS, Nascimento DS, Christoph DH, Guggino WB, Morales MM. Aldosterone and high-NaCl diet modulate ClC-2 chloride channel gene expression in rat kidney. PflüGers Archiv : European Journal of Physiology. 444: 193-201. PMID 11976932 DOI: 10.1007/s00424-002-0788-y  0.4
2002 Schwiebert EM, Wallace DP, Braunstein GM, King SR, Peti-Peterdi J, Hanaoka K, Guggino WB, Guay-Woodford LM, Bell PD, Sullivan LP, Grantham JJ, Taylor AL. Autocrine extracellular purinergic signaling in epithelial cells derived from polycystic kidneys. American Journal of Physiology. Renal Physiology. 282: F763-75. PMID 11880338 DOI: 10.1152/ajprenal.0337.2000  0.96
2002 Edmonds RD, Silva IV, Guggino WB, Butler RB, Zeitlin PL, Blaisdell CJ. ClC-5: ontogeny of an alternative chloride channel in respiratory epithelia. American Journal of Physiology. Lung Cellular and Molecular Physiology. 282: L501-7. PMID 11839544 DOI: 10.1152/ajplung.00207.2001  0.96
2002 Cheng J, Moyer BD, Milewski M, Loffing J, Ikeda M, Mickle JE, Cutting GR, Li M, Stanton BA, Guggino WB. A Golgi-associated PDZ domain protein modulates cystic fibrosis transmembrane regulator plasma membrane expression. The Journal of Biological Chemistry. 277: 3520-9. PMID 11707463 DOI: 10.1074/jbc.M110177200  0.88
2000 Wang SS, Devuyst O, Courtoy PJ, Wang XT, Wang H, Wang Y, Thakker RV, Guggino S, Guggino WB. Mice lacking renal chloride channel, CLC-5, are a model for Dent's disease, a nephrolithiasis disorder associated with defective receptor-mediated endocytosis. Human Molecular Genetics. 9: 2937-45. PMID 11115837  0.96
1998 Woo JS, Inoue CN, Hanaoka K, Schwiebert EM, Guggino SE, Guggino WB. Adenylyl cyclase is involved in desensitization and recovery of ATP-stimulated Clsecretion in MDCK cells. American Journal of Physiology. Cell Physiology. 274: C371-C378. PMID 29590930 DOI: 10.1152/ajpcell.1998.274.2.C371  0.68
1997 Morita T, Hanaoka K, Morales MM, Montrose-Rafizadeh C, Guggino WB. Cloning and characterization of maxi Kchannel α-subunit in rabbit kidney. American Journal of Physiology. Renal Physiology. 273: F615-F624. PMID 29587095 DOI: 10.1152/ajprenal.1997.273.4.F615  0.4
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