Peter H. Backx - Publications

University of Toronto, Toronto, ON, Canada 
Animal Physiology Biology, Cell Biology

157 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Kim KH, Backx PH. Understanding the Role of Iroquois Homeobox Transcription Factor 5 (IRX5) in Cardiac Function: Getting to the (Human) Heart of the Matter. Cardiovascular Research. PMID 33739382 DOI: 10.1093/cvr/cvab098  1
2021 Zheng S, Tan W, Li X, Li B, Gong B, Pyle WG, Wu J, Li L, Luo T, Zou Y, Yang FH, Backx PH. Aged Monkeys Fed a High-Fat/High-Sugar Diet Recapitulate Metabolic Disorders and Cardiac Contractile Dysfunction. Journal of Cardiovascular Translational Research. PMID 33591467 DOI: 10.1007/s12265-021-10105-z  0.44
2020 Oh Y, Yang S, Liu X, Jana S, Izaddoustdar F, Gao X, Debi R, Kim DK, Kim KH, Yang P, Kassiri Z, Lakin R, Backx PH. Transcriptomic Bioinformatic Analyses of Atria Uncover Involvement of Pathways Related to Strain and Post-translational Modification of Collagen in Increased Atrial Fibrillation Vulnerability in Intensely Exercised Mice. Frontiers in Physiology. 11: 605671. PMID 33424629 DOI: 10.3389/fphys.2020.605671  1
2020 Wu J, You J, Wang X, Wang S, Huang J, Xie Q, Gong B, Ding Z, Ye Y, Wang C, Kang L, Xu R, Li Y, Chen R, Sun A, ... ... Backx PH, et al. Left ventricular response in the transition from hypertrophy to failure recapitulates distinct roles of Akt, β-arrestin-2, and CaMKII in mice with aortic regurgitation. Annals of Translational Medicine. 8: 219. PMID 32309366 DOI: 10.21037/Atm.2020.01.51  0.4
2020 Li X, Zheng S, Tan W, Chen H, Li X, Wu J, Luo T, Ren X, Pyle WG, Wang L, Backx PH, Huang R, Yang FH. Slit2 Protects Hearts Against Ischemia-Reperfusion Injury by Inhibiting Inflammatory Responses and Maintaining Myofilament Contractile Properties. Frontiers in Physiology. 11: 228. PMID 32292352 DOI: 10.3389/Fphys.2020.00228  0.44
2020 Siraj MA, Mundil D, Beca S, Momen A, Shikatani EA, Afroze T, Sun X, Liu Y, Ghaffari S, Lee W, Wheeler MB, Keller G, Backx P, Husain M. Cardioprotective GLP-1 metabolite prevents ischemic cardiac injury by inhibiting mitochondrial trifunctional protein-α. The Journal of Clinical Investigation. PMID 31985487 DOI: 10.1172/Jci99934  0.4
2019 Lidington D, Fares JC, Uhl FE, Dinh DD, Kroetsch JT, Sauvé M, Malik FA, Matthes F, Vanherle L, Adel A, Momen A, Zhang H, Aschar-Sobbi R, Foltz WD, Wan H, ... ... Backx PH, et al. CFTR Therapeutics Normalize Cerebral Perfusion Deficits in Mouse Models of Heart Failure and Subarachnoid Hemorrhage. Jacc. Basic to Translational Science. 4: 940-958. PMID 31909302 DOI: 10.1016/J.Jacbts.2019.07.004  0.4
2019 Zhao Y, Rafatian N, Feric NT, Cox BJ, Aschar-Sobbi R, Wang EY, Aggarwal P, Zhang B, Conant G, Ronaldson-Bouchard K, Pahnke A, Protze S, Lee JH, Davenport Huyer L, Jekic D, ... ... Backx PH, et al. A Platform for Generation of Chamber-Specific Cardiac Tissues and Disease Modeling. Cell. PMID 30686581 DOI: 10.1016/J.Cell.2018.11.042  0.4
2018 Liu J, Bayer JD, Aschar-Sobbi R, Wauchop M, Spears D, Gollob M, Vigmond EJ, Tsushima R, Backx PH, Chauhan VS. Complex interactions in a novel SCN5A compound mutation associated with long QT and Brugada syndrome: Implications for Na+ channel blocking pharmacotherapy for de novo conduction disease. Plos One. 13: e0197273. PMID 29791480 DOI: 10.1371/Journal.Pone.0197273  0.36
2018 Barichello S, Roberts JD, Backx P, Boyle P, Laksman Z. Personalizing Therapy for Atrial Fibrillation: the Role of Stem Cell and in Silico Disease Models. Cardiovascular Research. PMID 29648634 DOI: 10.1093/cvr/cvy090  0.4
2018 Sadi AM, Afroze T, Siraj MA, Momen A, White-Dzuro C, Zarrin-Khat D, Handa S, Ban K, Kabir MG, Trivieri MG, Gros R, Backx P, Husain M. Cardiac-specific inducible over-expression of human Plasma Membrane CaATPase 4b is cardioprotective and improves survival in mice following ischemic injury. Clinical Science (London, England : 1979). PMID 29487197 DOI: 10.1042/Cs20171337  0.4
2017 Zeng Y, Du WW, Wu Y, Yang Z, Awan FM, Li X, Yang W, Zhang C, Yang Q, Yee A, Chen Y, Yang F, Sun H, Huang R, Yee AJ, ... ... Backx PH, et al. A Circular RNA Binds To and Activates AKT Phosphorylation and Nuclear Localization Reducing Apoptosis and Enhancing Cardiac Repair. Theranostics. 7: 3842-3855. PMID 29109781 DOI: 10.7150/Thno.19764  0.44
2017 Lee JH, Protze SI, Laksman Z, Backx PH, Keller GM. Human Pluripotent Stem Cell-Derived Atrial and Ventricular Cardiomyocytes Develop from Distinct Mesoderm Populations. Cell Stem Cell. 21: 179-194.e4. PMID 28777944 DOI: 10.1016/j.stem.2017.07.003  0.4
2017 Stanley-Hasnain S, Hauck L, Grothe D, Aschar-Sobbi R, Beca S, Butany J, Backx PH, Mak TW, Billia F. p53 and Mdm2 act synergistically to maintain cardiac homeostasis and mediate cardiomyocyte cell cycle arrest through a network of microRNAs. Cell Cycle (Georgetown, Tex.). 0. PMID 28745540 DOI: 10.1080/15384101.2017.1346758  0.36
2017 Laksman Z, Wauchop M, Lin E, Protze S, Lee J, Yang W, Izaddoustdar F, Shafaattalab S, Gepstein L, Tibbits GF, Keller G, Backx PH. Modeling Atrial Fibrillation using Human Embryonic Stem Cell-Derived Atrial Tissue. Scientific Reports. 7: 5268. PMID 28706272 DOI: 10.1038/S41598-017-05652-Y  0.4
2017 Yin JC, Platt MJ, Tian X, Wu X, Backx PH, Simpson JA, Araki T, Neel BG. Cellular interplay via cytokine hierarchy causes pathological cardiac hypertrophy in RAF1-mutant Noonan syndrome. Nature Communications. 8: 15518. PMID 28548091 DOI: 10.1038/ncomms15518  0.4
2017 Huang J, Wu J, Wang S, You J, Ye Y, Ding Z, Yang F, Wang X, Guo J, Ma L, Yuan J, Shen Y, Yang X, Sun A, Jiang H, ... ... Backx PH, et al. Ultrasound Biomicroscopy Validation of a Murine Model of Cardiac Hypertrophic Preconditioning: Comparison with a Hemodynamic Assessment. American Journal of Physiology. Heart and Circulatory Physiology. ajpheart.00004.2017. PMID 28455286 DOI: 10.1152/Ajpheart.00004.2017  0.4
2017 Kroetsch JT, Levy AS, Zhang H, Aschar-Sobbi R, Lidington D, Offermanns S, Nedospasov SA, Backx PH, Heximer SP, Bolz SS. Constitutive smooth muscle tumour necrosis factor regulates microvascular myogenic responsiveness and systemic blood pressure. Nature Communications. 8: 14805. PMID 28378814 DOI: 10.1038/Ncomms14805  0.36
2016 Protze SI, Liu J, Nussinovitch U, Ohana L, Backx PH, Gepstein L, Keller GM. Sinoatrial node cardiomyocytes derived from human pluripotent cells function as a biological pacemaker. Nature Biotechnology. PMID 27941801 DOI: 10.1038/nbt.3745  0.4
2016 Liu J, Laksman Z, Backx PH. The electrophysiological development of cardiomyocytes. Advanced Drug Delivery Reviews. PMID 26788696 DOI: 10.1016/j.addr.2015.12.023  0.64
2016 Kim KH, Rosen A, Hussein SM, Puviindran V, Korogyi AS, Chiarello C, Nagy A, Hui CC, Backx PH. Irx3 is required for postnatal maturation of the mouse ventricular conduction system. Scientific Reports. 6: 19197. PMID 26786475 DOI: 10.1038/Srep19197  0.64
2016 Panama BK, Korogyi AS, Aschar-Sobbi R, Oh Y, Gray CB, Gang H, Heller Brown J, Kirshenbaum LA, Backx PH. Reductions in the cardiac transient outward K+ current Ito caused by chronic β-adrenergic receptor stimulation are partly rescued by inhibition of nuclear factor kappaB. The Journal of Biological Chemistry. PMID 26742842 DOI: 10.1074/Jbc.M115.694984  0.64
2016 Cordeiro JM, Calloe K, Aschar-Sobbi R, Kim KH, Korogyi A, Occhipinti D, Backx PH, Panama BK. Physiological roles of the transient outward current Ito in normal and diseased hearts. Frontiers in Bioscience (Scholar Edition). 8: 143-59. PMID 26709904 DOI: 10.2741/S454  1
2015 Oudit GY, Backx PH. Amlodipine Therapy for Iron-Overload Cardiomyopathy: The Enduring Value of Translational Research. The Canadian Journal of Cardiology. PMID 27062235 DOI: 10.1016/J.Cjca.2015.11.017  0.56
2015 Liu J, Kim KH, Morales MJ, Heximer SP, Hui CC, Backx PH. Kv4.3-Encoded Fast Transient Outward Current Is Presented in Kv4.2 Knockout Mouse Cardiomyocytes. Plos One. 10: e0133274. PMID 26196737 DOI: 10.1371/Journal.Pone.0133274  0.64
2015 Chung YW, Lagranha C, Chen Y, Sun J, Tong G, Hockman SC, Ahmad F, Esfahani SG, Bae DH, Polidovitch N, Wu J, Rhee DK, Lee BS, Gucek M, Daniels MP, ... ... Backx PH, et al. Targeted disruption of PDE3B, but not PDE3A, protects murine heart from ischemia/reperfusion injury. Proceedings of the National Academy of Sciences of the United States of America. 112: E2253-62. PMID 25877153 DOI: 10.1073/Pnas.1416230112  0.64
2015 Aschar-Sobbi R, Izaddoustdar F, Korogyi AS, Wang Q, Farman GP, Yang F, Yang W, Dorian D, Simpson JA, Tuomi JM, Jones DL, Nanthakumar K, Cox B, Wehrens XH, Dorian P, ... Backx PH, et al. Increased atrial arrhythmia susceptibility induced by intense endurance exercise in mice requires TNFα. Nature Communications. 6: 6018. PMID 25598495 DOI: 10.1038/Ncomms7018  0.64
2015 Jackson N, Massé S, Zamiri N, Azam MA, Lai PFH, Kusha M, Asta J, Quadros K, King B, Backx P, Ideker RE, Nanthakumar K. Mechanisms of long-duration ventricular fibrillation in human hearts and experimental validation in canine Purkinje fibers Jacc: Clinical Electrophysiology. 1: 187-197. DOI: 10.1016/j.jacep.2015.04.003  0.64
2014 Wang DY, Abbasi C, El-Rass S, Li JY, Dawood F, Naito K, Sharma P, Bousette N, Singh S, Backx PH, Cox B, Wen XY, Liu PP, Gramolini AO. Endoplasmic reticulum resident protein 44 (ERp44) deficiency in mice and zebrafish leads to cardiac developmental and functional defects. Journal of the American Heart Association. 3: e001018. PMID 25332179 DOI: 10.1161/Jaha.114.001018  0.64
2014 Perrin MJ, Adler A, Green S, Al-Zoughool F, Doroshenko P, Orr N, Uppal S, Healey JS, Birnie D, Sanatani S, Gardner M, Champagne J, Simpson C, Ahmad K, van den Berg MP, ... ... Backx PH, et al. Evaluation of genes encoding for the transient outward current (Ito) identifies the KCND2 gene as a cause of J-wave syndrome associated with sudden cardiac death. Circulation. Cardiovascular Genetics. 7: 782-9. PMID 25214526 DOI: 10.1161/Circgenetics.114.000623  0.64
2014 Xie L, Liang T, Kang Y, Lin X, Sobbi R, Xie H, Chao C, Backx P, Feng ZP, Shyng SL, Gaisano HY. Phosphatidylinositol 4,5-biphosphate (PIP2) modulates syntaxin-1A binding to sulfonylurea receptor 2A to regulate cardiac ATP-sensitive potassium (KATP) channels. Journal of Molecular and Cellular Cardiology. 75: 100-10. PMID 25073062 DOI: 10.1016/J.Yjmcc.2014.07.012  0.64
2014 Diaz RJ, Harvey K, Boloorchi A, Hossain T, Hinek A, Backx PH, Wilson GJ. Enhanced cell volume regulation: a key mechanism in local and remote ischemic preconditioning. American Journal of Physiology. Cell Physiology. 306: C1191-9. PMID 24760980 DOI: 10.1152/Ajpcell.00259.2013  0.64
2014 Vanderlaan RD, Caldarone CA, Backx PH. Heart failure in congenital heart disease: the role of genes and hemodynamics. PflüGers Archiv : European Journal of Physiology. 466: 1025-35. PMID 24488006 DOI: 10.1007/S00424-014-1447-9  0.32
2014 Zamiri N, Massé S, Ramadeen A, Kusha M, Hu X, Azam MA, Liu J, Lai PF, Vigmond EJ, Boyle PM, Behradfar E, Al-Hesayen A, Waxman MB, Backx P, Dorian P, et al. Dantrolene improves survival after ventricular fibrillation by mitigating impaired calcium handling in animal models. Circulation. 129: 875-85. PMID 24403563 DOI: 10.1161/Circulationaha.113.005443  0.64
2014 Liang W, Huang L, Zhao D, He JZ, Sharma P, Liu J, Gramolini AO, Ward ME, Cho HC, Backx PH. Swelling-activated Cl- currents and intracellular CLC-3 are involved in proliferation of human pulmonary artery smooth muscle cells. Journal of Hypertension. 32: 318-30. PMID 24284495 DOI: 10.1097/Hjh.0000000000000013  0.64
2013 Kelsey L, Flenniken AM, Qu D, Funnell AP, Pearson R, Zhou YQ, Voronina I, Berberovic Z, Wood G, Newbigging S, Weiss ES, Wong M, Quach I, Yeh SY, Deshwar AR, ... ... Backx P, et al. ENU-induced mutation in the DNA-binding domain of KLF3 reveals important roles for KLF3 in cardiovascular development and function in mice. Plos Genetics. 9: e1003612. PMID 23874215 DOI: 10.1371/Journal.Pgen.1003612  0.64
2013 Nunes SS, Miklas JW, Liu J, Aschar-Sobbi R, Xiao Y, Zhang B, Jiang J, Massé S, Gagliardi M, Hsieh A, Thavandiran N, Laflamme MA, Nanthakumar K, Gross GJ, Backx PH, et al. Biowire: a platform for maturation of human pluripotent stem cell-derived cardiomyocytes. Nature Methods. 10: 781-7. PMID 23793239 DOI: 10.1038/Nmeth.2524  0.64
2013 Lai PF, Panama BK, Massé S, Li G, Zhang Y, Kusha M, Farid TA, Asta J, Backx PH, Yau TM, Nanthakumar K. Mesenchymal stem cell transplantation mitigates electrophysiological remodeling in a rat model of myocardial infarction. Journal of Cardiovascular Electrophysiology. 24: 813-21. PMID 23647964 DOI: 10.1111/Jce.12162  0.64
2013 Kim M, Platt MJ, Shibasaki T, Quaggin SE, Backx PH, Seino S, Simpson JA, Drucker DJ. GLP-1 receptor activation and Epac2 link atrial natriuretic peptide secretion to control of blood pressure. Nature Medicine. 19: 567-75. PMID 23542788 DOI: 10.1038/Nm.3128  0.4
2013 Jadhav A, Liang W, Papageorgiou PC, Shoker A, Kanthan SC, Balsevich J, Levy AS, Heximer S, Backx PH, Gopalakrishnan V. Catharanthine dilates small mesenteric arteries and decreases heart rate and cardiac contractility by inhibition of voltage-operated calcium channels on vascular smooth muscle cells and cardiomyocytes. The Journal of Pharmacology and Experimental Therapeutics. 345: 383-92. PMID 23532933 DOI: 10.1124/Jpet.112.199661  0.64
2013 Rose RA, Backx PH. Calcium Channels in the Heart Cardiac Electrophysiology: From Cell to Bedside: Sixth Edition. 13-22. DOI: 10.1016/B978-1-4557-2856-5.00002-9  0.64
2012 Chis R, Sharma P, Bousette N, Miyake T, Wilson A, Backx PH, Gramolini AO. α-Crystallin B prevents apoptosis after H2O2 exposure in mouse neonatal cardiomyocytes. American Journal of Physiology. Heart and Circulatory Physiology. 303: H967-78. PMID 22904156 DOI: 10.1152/Ajpheart.00040.2012  0.64
2012 Wu X, Yin J, Simpson J, Kim KH, Gu S, Hong JH, Bayliss P, Backx PH, Neel BG, Araki T. Increased BRAF heterodimerization is the common pathogenic mechanism for noonan syndrome-associated RAF1 mutants. Molecular and Cellular Biology. 32: 3872-90. PMID 22826437 DOI: 10.1128/Mcb.00751-12  0.64
2012 Nair K, Pekhletski R, Harris L, Care M, Morel C, Farid T, Backx PH, Szabo E, Nanthakumar K. Escape capture bigeminy: phenotypic marker of cardiac sodium channel voltage sensor mutation R222Q. Heart Rhythm : the Official Journal of the Heart Rhythm Society. 9: 1681-1688.e1. PMID 22710484 DOI: 10.1016/J.Hrthm.2012.06.029  0.72
2012 Kim KH, Rosen A, Bruneau BG, Hui CC, Backx PH. Iroquois homeodomain transcription factors in heart development and function. Circulation Research. 110: 1513-24. PMID 22628575 DOI: 10.1161/Circresaha.112.265041  1
2012 Degousee N, Simpson J, Fazel S, Scholich K, Angoulvant D, Angioni C, Schmidt H, Korotkova M, Stefanski E, Wang XH, Lindsay TF, Ofek E, Pierre S, Butany J, Jakobsson PJ, ... ... Backx PH, et al. Lack of microsomal prostaglandin E(2) synthase-1 in bone marrow-derived myeloid cells impairs left ventricular function and increases mortality after acute myocardial infarction. Circulation. 125: 2904-13. PMID 22589381 DOI: 10.1161/Circulationaha.112.099754  0.4
2012 Papageorgiou PC, Yeo EL, Backx PH, Floras JS. A new enzyme-linked immunosorbent assay recognizing both rat and human activated coagulation Factor XII (FXIIa). Journal of Immunological Methods. 376: 132-8. PMID 22251663 DOI: 10.1016/J.Jim.2012.01.002  0.64
2012 Papageorgiou PC, Yeo EL, Backx PH, Floras JS. Activated plasma coagulation β-Factor XII-induced vasoconstriction in rats. Clinical Science (London, England : 1979). 122: 581-90. PMID 22216926 DOI: 10.1042/Cs20110517  0.64
2012 Jadhav A, Liang W, Balsevich J, Bastin G, Kroetsch J, Heximer S, Backx PH, Gopalakrishnan V. L-tryptophan ethyl ester dilates small mesenteric arteries by inhibition of voltage-operated calcium channels in smooth muscle. British Journal of Pharmacology. 166: 232-42. PMID 21951131 DOI: 10.1111/J.1476-5381.2011.01693.X  0.32
2011 Beca S, Aschars-Sobbi R, Panama BK, Backx PH. Regulation of murine cardiac function by phosphodiesterases type 3 and 4. Current Opinion in Pharmacology. 11: 714-9. PMID 22047792 DOI: 10.1016/J.Coph.2011.10.017  0.36
2011 Kim JI, Lee HR, Sim SE, Baek J, Yu NK, Choi JH, Ko HG, Lee YS, Park SW, Kwak C, Ahn SJ, Choi SY, Kim H, Kim KH, Backx PH, et al. PI3Kγ is required for NMDA receptor-dependent long-term depression and behavioral flexibility. Nature Neuroscience. 14: 1447-54. PMID 22019731 DOI: 10.1038/Nn.2937  0.64
2011 Beca S, Helli PB, Simpson JA, Zhao D, Farman GP, Jones PP, Tian X, Wilson LS, Ahmad F, Chen SR, Movsesian MA, Manganiello V, Maurice DH, Conti M, Backx PH. Phosphodiesterase 4D regulates baseline sarcoplasmic reticulum Ca2+ release and cardiac contractility, independently of L-type Ca2+ current. Circulation Research. 109: 1024-30. PMID 21903937 DOI: 10.1161/Circresaha.111.250464  0.64
2011 Zhang SS, Kim KH, Rosen A, Smyth JW, Sakuma R, Delgado-Olguín P, Davis M, Chi NC, Puviindran V, Gaborit N, Sukonnik T, Wylie JN, Brand-Arzamendi K, Farman GP, Kim J, ... ... Backx PH, et al. Iroquois homeobox gene 3 establishes fast conduction in the cardiac His-Purkinje network. Proceedings of the National Academy of Sciences of the United States of America. 108: 13576-81. PMID 21825130 DOI: 10.1073/Pnas.1106911108  0.64
2011 Ramirez RJ, Sah R, Liu J, Rose RA, Backx PH. Intracellular [Na(+)] modulates synergy between Na(+)/Ca (2+) exchanger and L-type Ca (2+) current in cardiac excitation-contraction coupling during action potentials. Basic Research in Cardiology. 106: 967-77. PMID 21779914 DOI: 10.1007/S00395-011-0202-Z  0.64
2011 Rose RA, Sellan M, Simpson JA, Izaddoustdar F, Cifelli C, Panama BK, Davis M, Zhao D, Markhani M, Murphy GG, Striessnig J, Liu PP, Heximer SP, Backx PH. Iron overload decreases CaV1.3-dependent L-type Ca2+ currents leading to bradycardia, altered electrical conduction, and atrial fibrillation. Circulation. Arrhythmia and Electrophysiology. 4: 733-42. PMID 21747058 DOI: 10.1161/Circep.110.960401  0.64
2011 Tupling AR, Bombardier E, Gupta SC, Hussain D, Vigna C, Bloemberg D, Quadrilatero J, Trivieri MG, Babu GJ, Backx PH, Periasamy M, MacLennan DH, Gramolini AO. Enhanced Ca2+ transport and muscle relaxation in skeletal muscle from sarcolipin-null mice. American Journal of Physiology. Cell Physiology. 301: C841-9. PMID 21697544 DOI: 10.1152/Ajpcell.00409.2010  0.64
2011 Martino TA, Tata N, Simpson JA, Vanderlaan R, Dawood F, Kabir MG, Khaper N, Cifelli C, Podobed P, Liu PP, Husain M, Heximer S, Backx PH, Sole MJ. The primary benefits of angiotensin-converting enzyme inhibition on cardiac remodeling occur during sleep time in murine pressure overload hypertrophy. Journal of the American College of Cardiology. 57: 2020-8. PMID 21565639 DOI: 10.1016/J.Jacc.2010.11.022  0.64
2011 Wu X, Simpson J, Hong JH, Kim KH, Thavarajah NK, Backx PH, Neel BG, Araki T. MEK-ERK pathway modulation ameliorates disease phenotypes in a mouse model of Noonan syndrome associated with the Raf1(L613V) mutation. The Journal of Clinical Investigation. 121: 1009-25. PMID 21339642 DOI: 10.1172/Jci44929  0.64
2011 Liu J, Kim KH, London B, Morales MJ, Backx PH. Dissection of the voltage-activated potassium outward currents in adult mouse ventricular myocytes: I(to,f), I(to,s), I(K,slow1), I(K,slow2), and I(ss). Basic Research in Cardiology. 106: 189-204. PMID 21253754 DOI: 10.1007/S00395-010-0134-Z  0.64
2011 Panama BK, Latour-Villamil D, Farman GP, Zhao D, Bolz SS, Kirshenbaum LA, Backx PH. Nuclear factor kappaB downregulates the transient outward potassium current I(to,f) through control of KChIP2 expression. Circulation Research. 108: 537-43. PMID 21252158 DOI: 10.1161/Circresaha.110.229112  0.64
2011 Ye L, Zhu W, Backx PH, Cortez MA, Wu J, Chow YH, McKerlie C, Wang A, Tsui LC, Gross GJ, Hu J. Arrhythmia and sudden death associated with elevated cardiac chloride channel activity. Journal of Cellular and Molecular Medicine. 15: 2307-16. PMID 21155978 DOI: 10.1111/J.1582-4934.2010.01243.X  0.64
2011 Vanderlaan RD, Hardy WR, Kabir MG, Pasculescu A, Jones N, deTombe PP, Backx PH, Pawson T. The ShcA phosphotyrosine docking protein uses distinct mechanisms to regulate myocyte and global heart function. Circulation Research. 108: 184-93. PMID 21148430 DOI: 10.1161/Circresaha.110.233924  0.32
2011 Li J, Xuan W, Yan R, Tropak MB, Jean-St-Michel E, Liang W, Gladstone R, Backx PH, Kharbanda RK, Redington AN. Remote preconditioning provides potent cardioprotection via PI3K/Akt activation and is associated with nuclear accumulation of β-catenin. Clinical Science (London, England : 1979). 120: 451-62. PMID 21143191 DOI: 10.1042/Cs20100466  0.32
2011 Mueller EE, Momen A, Massé S, Zhou YQ, Liu J, Backx PH, Henkelman RM, Nanthakumar K, Stewart DJ, Husain M. Electrical remodelling precedes heart failure in an endothelin-1-induced model of cardiomyopathy. Cardiovascular Research. 89: 623-33. PMID 21062919 DOI: 10.1093/Cvr/Cvq351  0.64
2010 Farman GP, Allen EJ, Schoenfelt KQ, Backx PH, de Tombe PP. The role of thin filament cooperativity in cardiac length-dependent calcium activation. Biophysical Journal. 99: 2978-86. PMID 21044595 DOI: 10.1016/J.Bpj.2010.09.003  0.64
2010 Bousette N, Chugh S, Fong V, Isserlin R, Kim KH, Volchuk A, Backx PH, Liu P, Kislinger T, MacLennan DH, Emili A, Gramolini AO. Constitutively active calcineurin induces cardiac endoplasmic reticulum stress and protects against apoptosis that is mediated by alpha-crystallin-B. Proceedings of the National Academy of Sciences of the United States of America. 107: 18481-6. PMID 20937869 DOI: 10.1073/Pnas.1013555107  0.64
2010 Guo D, Kassiri Z, Basu R, Chow FL, Kandalam V, Damilano F, Liang W, Izumo S, Hirsch E, Penninger JM, Backx PH, Oudit GY. Loss of PI3Kγ enhances cAMP-dependent MMP remodeling of the myocardial N-cadherin adhesion complexes and extracellular matrix in response to early biomechanical stress. Circulation Research. 107: 1275-89. PMID 20847309 DOI: 10.1161/Circresaha.110.229054  0.64
2010 Liang W, Oudit GY, Patel MM, Shah AM, Woodgett JR, Tsushima RG, Ward ME, Backx PH. Role of phosphoinositide 3-kinase {alpha}, protein kinase C, and L-type Ca2+ channels in mediating the complex actions of angiotensin II on mouse cardiac contractility. Hypertension. 56: 422-9. PMID 20696985 DOI: 10.1161/Hypertensionaha.109.149344  0.64
2010 Belik J, Stevens D, Pan J, McIntyre BA, Kantores C, Ivanovska J, Xu EZ, Ibrahim C, Panama BK, Backx PH, McNamara PJ, Jankov RP. Pulmonary vascular and cardiac effects of peroxynitrite decomposition in newborn rats. Free Radical Biology & Medicine. 49: 1306-14. PMID 20688155 DOI: 10.1016/J.Freeradbiomed.2010.07.021  0.64
2010 Ban K, Kim KH, Cho CK, Sauvé M, Diamandis EP, Backx PH, Drucker DJ, Husain M. Glucagon-like peptide (GLP)-1(9-36)amide-mediated cytoprotection is blocked by exendin(9-39) yet does not require the known GLP-1 receptor. Endocrinology. 151: 1520-31. PMID 20172966 DOI: 10.1210/En.2009-1197  1
2009 D'Avanzo N, Pekhletski R, Backx PH. P-loop residues critical for selectivity in K channels fail to confer selectivity to rabbit HCN4 channels. Plos One. 4: e7712. PMID 19890386 DOI: 10.1371/Journal.Pone.0007712  0.72
2009 Liang W, Ray JB, He JZ, Backx PH, Ward ME. Regulation of proliferation and membrane potential by chloride currents in rat pulmonary artery smooth muscle cells. Hypertension. 54: 286-93. PMID 19581510 DOI: 10.1161/Hypertensionaha.109.130138  0.32
2008 Rose RA, Keating A, Backx PH. Do mesenchymal stromal cells transdifferentiate into functional cardiomyocytes? Circulation Research. 103: e120. PMID 18948624 DOI: 10.1161/Circresaha.108.186908  0.64
2008 Ban K, Cooper AJ, Samuel S, Bhatti A, Patel M, Izumo S, Penninger JM, Backx PH, Oudit GY, Tsushima RG. Phosphatidylinositol 3-kinase gamma is a critical mediator of myocardial ischemic and adenosine-mediated preconditioning. Circulation Research. 103: 643-53. PMID 18688045 DOI: 10.1161/Circresaha.108.175018  0.64
2008 Rose RA, Jiang H, Wang X, Helke S, Tsoporis JN, Gong N, Keating SC, Parker TG, Backx PH, Keating A. Bone marrow-derived mesenchymal stromal cells express cardiac-specific markers, retain the stromal phenotype, and do not become functional cardiomyocytes in vitro. Stem Cells (Dayton, Ohio). 26: 2884-92. PMID 18687994 DOI: 10.1634/Stemcells.2008-0329  0.64
2008 Lovren F, Pan Y, Quan A, Teoh H, Wang G, Shukla PC, Levitt KS, Oudit GY, Al-Omran M, Stewart DJ, Slutsky AS, Peterson MD, Backx PH, Penninger JM, Verma S. Angiotensin converting enzyme-2 confers endothelial protection and attenuates atherosclerosis. American Journal of Physiology. Heart and Circulatory Physiology. 295: H1377-84. PMID 18660448 DOI: 10.1152/Ajpheart.00331.2008  0.64
2008 Cifelli C, Rose RA, Zhang H, Voigtlaender-Bolz J, Bolz SS, Backx PH, Heximer SP. RGS4 regulates parasympathetic signaling and heart rate control in the sinoatrial node. Circulation Research. 103: 527-35. PMID 18658048 DOI: 10.1161/Circresaha.108.180984  0.64
2008 Zhu Y, Gramolini AO, Walsh MA, Zhou YQ, Slorach C, Friedberg MK, Takeuchi JK, Sun H, Henkelman RM, Backx PH, Redington AN, Maclennan DH, Bruneau BG. Tbx5-dependent pathway regulating diastolic function in congenital heart disease. Proceedings of the National Academy of Sciences of the United States of America. 105: 5519-24. PMID 18378906 DOI: 10.1073/Pnas.0801779105  0.64
2008 Eremina V, Jefferson JA, Kowalewska J, Hochster H, Haas M, Weisstuch J, Richardson C, Kopp JB, Kabir MG, Backx PH, Gerber HP, Ferrara N, Barisoni L, Alpers CE, Quaggin SE. VEGF inhibition and renal thrombotic microangiopathy. The New England Journal of Medicine. 358: 1129-36. PMID 18337603 DOI: 10.1056/Nejmoa0707330  0.64
2008 Oudit GY, Kassiri Z, Zhou J, Liu QC, Liu PP, Backx PH, Dawood F, Crackower MA, Scholey JW, Penninger JM. Loss of PTEN attenuates the development of pathological hypertrophy and heart failure in response to biomechanical stress. Cardiovascular Research. 78: 505-14. PMID 18281373 DOI: 10.1093/Cvr/Cvn041  0.64
2008 Martino TA, Oudit GY, Herzenberg AM, Tata N, Koletar MM, Kabir GM, Belsham DD, Backx PH, Ralph MR, Sole MJ. Circadian rhythm disorganization produces profound cardiovascular and renal disease in hamsters. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 294: R1675-83. PMID 18272659 DOI: 10.1152/Ajpregu.00829.2007  0.64
2008 Gramolini AO, Kislinger T, Alikhani-Koopaei R, Fong V, Thompson NJ, Isserlin R, Sharma P, Oudit GY, Trivieri MG, Fagan A, Kannan A, Higgins DG, Huedig H, Hess G, Arab S, ... ... Backx PH, et al. Comparative proteomics profiling of a phospholamban mutant mouse model of dilated cardiomyopathy reveals progressive intracellular stress responses. Molecular & Cellular Proteomics : McP. 7: 519-33. PMID 18056057 DOI: 10.1074/Mcp.M700245-Mcp200  0.64
2008 Kim KH, Oudit GY, Backx PH. Erythropoietin protects against doxorubicin-induced cardiomyopathy via a phosphatidylinositol 3-kinase-dependent pathway. The Journal of Pharmacology and Experimental Therapeutics. 324: 160-9. PMID 17928571 DOI: 10.1124/Jpet.107.125773  1
2007 Rose RA, Kabir MG, Backx PH. Altered heart rate and sinoatrial node function in mice lacking the cAMP regulator phosphoinositide 3-kinase-gamma. Circulation Research. 101: 1274-82. PMID 17975110 DOI: 10.1161/Circresaha.107.158428  0.64
2007 Kerfant BG, Zhao D, Lorenzen-Schmidt I, Wilson LS, Cai S, Chen SR, Maurice DH, Backx PH. PI3Kgamma is required for PDE4, not PDE3, activity in subcellular microdomains containing the sarcoplasmic reticular calcium ATPase in cardiomyocytes. Circulation Research. 101: 400-8. PMID 17615371 DOI: 10.1161/Circresaha.107.156422  0.64
2007 Wong DW, Oudit GY, Reich H, Kassiri Z, Zhou J, Liu QC, Backx PH, Penninger JM, Herzenberg AM, Scholey JW. Loss of angiotensin-converting enzyme-2 (Ace2) accelerates diabetic kidney injury. The American Journal of Pathology. 171: 438-51. PMID 17600118 DOI: 10.2353/Ajpath.2007.060977  0.64
2007 Mu J, Qu D, Bartczak A, Phillips MJ, Manuel J, He W, Koscik C, Mendicino M, Zhang L, Clark DA, Grant DR, Backx PH, Levy GA, Adamson SL. Fgl2 deficiency causes neonatal death and cardiac dysfunction during embryonic and postnatal development in mice. Physiological Genomics. 31: 53-62. PMID 17550996 DOI: 10.1152/Physiolgenomics.00026.2007  0.64
2007 Oudit GY, Kassiri Z, Patel MP, Chappell M, Butany J, Backx PH, Tsushima RG, Scholey JW, Khokha R, Penninger JM. Angiotensin II-mediated oxidative stress and inflammation mediate the age-dependent cardiomyopathy in ACE2 null mice. Cardiovascular Research. 75: 29-39. PMID 17499227 DOI: 10.1016/J.Cardiores.2007.04.007  0.64
2007 Oudit GY, Korley V, Backx PH, Dorian P. Lithium-induced sinus node disease at therapeutic concentrations: linking lithium-induced blockade of sodium channels to impaired pacemaker activity. The Canadian Journal of Cardiology. 23: 229-32. PMID 17347696 DOI: 10.1016/S0828-282X(07)70750-X  0.56
2007 Martino TA, Tata N, Belsham DD, Chalmers J, Straume M, Lee P, Pribiag H, Khaper N, Liu PP, Dawood F, Backx PH, Ralph MR, Sole MJ. Disturbed diurnal rhythm alters gene expression and exacerbates cardiovascular disease with rescue by resynchronization. Hypertension. 49: 1104-13. PMID 17339537 DOI: 10.1161/Hypertensionaha.106.083568  0.64
2007 Anini Y, Izzo A, Oudit GY, Backx PH, Brubaker PL. Role of phosphatidylinositol-3 kinase-gamma in the actions of glucagon-like peptide-2 on the murine small intestine. American Journal of Physiology. Endocrinology and Metabolism. 292: E1599-606. PMID 17284578 DOI: 10.1152/Ajpendo.00429.2006  0.56
2006 Gong N, Bodi I, Zobel C, Schwartz A, Molkentin JD, Backx PH. Calcineurin increases cardiac transient outward K+ currents via transcriptional up-regulation of Kv4.2 channel subunits. The Journal of Biological Chemistry. 281: 38498-506. PMID 17060317 DOI: 10.1074/Jbc.M607774200  0.64
2006 Kerfant BG, Rose RA, Sun H, Backx PH. Phosphoinositide 3-kinase gamma regulates cardiac contractility by locally controlling cyclic adenosine monophosphate levels. Trends in Cardiovascular Medicine. 16: 250-6. PMID 16980183 DOI: 10.1016/J.Tcm.2006.04.006  0.64
2006 Oudit GY, Herzenberg AM, Kassiri Z, Wong D, Reich H, Khokha R, Crackower MA, Backx PH, Penninger JM, Scholey JW. Loss of angiotensin-converting enzyme-2 leads to the late development of angiotensin II-dependent glomerulosclerosis. The American Journal of Pathology. 168: 1808-20. PMID 16723697 DOI: 10.2353/Ajpath.2006.051091  0.64
2006 Sun H, Kerfant BG, Zhao D, Trivieri MG, Oudit GY, Penninger JM, Backx PH. Insulin-like growth factor-1 and PTEN deletion enhance cardiac L-type Ca2+ currents via increased PI3Kalpha/PKB signaling. Circulation Research. 98: 1390-7. PMID 16627784 DOI: 10.1161/01.Res.0000223321.34482.8C  0.56
2006 Oudit GY, Trivieri MG, Khaper N, Liu PP, Backx PH. Role of L-type Ca2+ channels in iron transport and iron-overload cardiomyopathy. Journal of Molecular Medicine (Berlin, Germany). 84: 349-64. PMID 16604332 DOI: 10.1007/S00109-005-0029-X  0.56
2006 Trivieri MG, Oudit GY, Sah R, Kerfant BG, Sun H, Gramolini AO, Pan Y, Wickenden AD, Croteau W, Morreale de Escobar G, Pekhletski R, St Germain D, Maclennan DH, Backx PH. Cardiac-specific elevations in thyroid hormone enhance contractility and prevent pressure overload-induced cardiac dysfunction. Proceedings of the National Academy of Sciences of the United States of America. 103: 6043-8. PMID 16595628 DOI: 10.1073/Pnas.0601072103  0.64
2006 Li LX, MacDonald PE, Ahn DS, Oudit GY, Backx PH, Brubaker PL. Role of phosphatidylinositol 3-kinasegamma in the beta-cell: interactions with glucagon-like peptide-1. Endocrinology. 147: 3318-25. PMID 16574789 DOI: 10.1210/En.2006-0155  0.56
2006 So PP, Hu XD, Backx PH, Puglisi JL, Dorian P. Blockade of IKs by HMR 1556 increases the reverse rate-dependence of refractoriness prolongation by dofetilide in isolated rabbit ventricles. British Journal of Pharmacology. 148: 255-63. PMID 16565733 DOI: 10.1038/Sj.Bjp.0706721  0.64
2006 Xu J, Gong NL, Bodi I, Aronow BJ, Backx PH, Molkentin JD. Myocyte enhancer factors 2A and 2C induce dilated cardiomyopathy in transgenic mice. The Journal of Biological Chemistry. 281: 9152-62. PMID 16469744 DOI: 10.1074/Jbc.M510217200  0.36
2006 Gramolini AO, Trivieri MG, Oudit GY, Kislinger T, Li W, Patel MM, Emili A, Kranias EG, Backx PH, Maclennan DH. Cardiac-specific overexpression of sarcolipin in phospholamban null mice impairs myocyte function that is restored by phosphorylation. Proceedings of the National Academy of Sciences of the United States of America. 103: 2446-51. PMID 16461894 DOI: 10.1073/Pnas.0510883103  0.64
2005 Joza N, Oudit GY, Brown D, Bénit P, Kassiri Z, Vahsen N, Benoit L, Patel MM, Nowikovsky K, Vassault A, Backx PH, Wada T, Kroemer G, Rustin P, Penninger JM. Muscle-specific loss of apoptosis-inducing factor leads to mitochondrial dysfunction, skeletal muscle atrophy, and dilated cardiomyopathy. Molecular and Cellular Biology. 25: 10261-72. PMID 16287843 DOI: 10.1128/Mcb.25.23.10261-10272.2005  0.64
2005 Hui K, Gardzinski P, Sun HS, Backx PH, Feng ZP. Permeable ions differentially affect gating kinetics and unitary conductance of L-type calcium channels. Biochemical and Biophysical Research Communications. 338: 783-92. PMID 16243294 DOI: 10.1016/J.Bbrc.2005.10.014  0.64
2005 Costantini DL, Arruda EP, Agarwal P, Kim KH, Zhu Y, Zhu W, Lebel M, Cheng CW, Park CY, Pierce SA, Guerchicoff A, Pollevick GD, Chan TY, Kabir MG, Cheng SH, ... ... Backx PH, et al. The homeodomain transcription factor Irx5 establishes the mouse cardiac ventricular repolarization gradient. Cell. 123: 347-58. PMID 16239150 DOI: 10.1016/J.Cell.2005.08.004  1
2005 Kassiri Z, Oudit GY, Sanchez O, Dawood F, Mohammed FF, Nuttall RK, Edwards DR, Liu PP, Backx PH, Khokha R. Combination of tumor necrosis factor-alpha ablation and matrix metalloproteinase inhibition prevents heart failure after pressure overload in tissue inhibitor of metalloproteinase-3 knock-out mice. Circulation Research. 97: 380-90. PMID 16037568 DOI: 10.1161/01.Res.0000178789.16929.Cf  0.64
2005 Kerfant BG, Gidrewicz D, Sun H, Oudit GY, Penninger JM, Backx PH. Cardiac sarcoplasmic reticulum calcium release and load are enhanced by subcellular cAMP elevations in PI3Kgamma-deficient mice. Circulation Research. 96: 1079-86. PMID 15860757 DOI: 10.1161/01.Res.0000168066.06333.Df  0.56
2005 D'Avanzo N, Cho HC, Tolokh I, Pekhletski R, Tolokh I, Gray C, Goldman S, Backx PH. Conduction through the inward rectifier potassium channel, Kir2.1, is increased by negatively charged extracellular residues. The Journal of General Physiology. 125: 493-503. PMID 15824191 DOI: 10.1085/Jgp.200409175  0.64
2005 Tolokh IS, Tolokh II, Cho HC, D'Avanzo N, Backx PH, Goldman S, Gray CG. Non-Michaelis-Menten kinetics model for conductance of low-conductance potassium ion channels. Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics. 71: 021912. PMID 15783357 DOI: 10.1103/Physreve.71.021912  0.64
2005 Tsang SY, Tsushima RG, Tomaselli GF, Li RA, Backx PH. A multifunctional aromatic residue in the external pore vestibule of Na+ channels contributes to the local anesthetic receptor. Molecular Pharmacology. 67: 424-34. PMID 15659774 DOI: 10.1124/Mol.67.2  0.64
2005 Ricci R, Eriksson U, Oudit GY, Eferl R, Akhmedov A, Sumara I, Sumara G, Kassiri Z, David JP, Bakiri L, Sasse B, Idarraga MH, Rath M, Kurz D, Theussl HC, ... ... Backx P, et al. Distinct functions of junD in cardiac hypertrophy and heart failure. Genes & Development. 19: 208-13. PMID 15655111 DOI: 10.1101/Gad.327005  0.64
2004 Oudit GY, Sun H, Kerfant BG, Crackower MA, Penninger JM, Backx PH. The role of phosphoinositide-3 kinase and PTEN in cardiovascular physiology and disease. Journal of Molecular and Cellular Cardiology. 37: 449-71. PMID 15276015 DOI: 10.1016/J.Yjmcc.2004.05.015  0.56
2004 Diaz RJ, Zobel C, Cho HC, Batthish M, Hinek A, Backx PH, Wilson GJ. Selective inhibition of inward rectifier K+ channels (Kir2.1 or Kir2.2) abolishes protection by ischemic preconditioning in rabbit ventricular cardiomyocytes. Circulation Research. 95: 325-32. PMID 15231687 DOI: 10.1161/01.Res.0000137727.34938.35  0.56
2004 Asahi M, Otsu K, Nakayama H, Hikoso S, Takeda T, Gramolini AO, Trivieri MG, Oudit GY, Morita T, Kusakari Y, Hirano S, Hongo K, Hirotani S, Yamaguchi O, Peterson A, ... Backx PH, et al. Cardiac-specific overexpression of sarcolipin inhibits sarco(endo)plasmic reticulum Ca2+ ATPase (SERCA2a) activity and impairs cardiac function in mice. Proceedings of the National Academy of Sciences of the United States of America. 101: 9199-204. PMID 15201433 DOI: 10.1073/Pnas.0402596101  0.64
2004 Sun H, Oudit GY, Ramirez RJ, Costantini D, Backx PH. The phosphoinositide 3-kinase inhibitor LY294002 enhances cardiac myocyte contractility via a direct inhibition of Ik,slow currents. Cardiovascular Research. 62: 509-20. PMID 15158143 DOI: 10.1016/J.Cardiores.2004.01.029  0.6
2004 Oudit GY, Trivieri MG, Khaper N, Husain T, Wilson GJ, Liu P, Sole MJ, Backx PH. Taurine supplementation reduces oxidative stress and improves cardiovascular function in an iron-overload murine model. Circulation. 109: 1877-85. PMID 15037530 DOI: 10.1161/01.Cir.0000124229.40424.80  0.64
2003 Oudit GY, Crackower MA, Eriksson U, Sarao R, Kozieradzki I, Sasaki T, Irie-Sasaki J, Gidrewicz D, Rybin VO, Wada T, Steinberg SF, Backx PH, Penninger JM. Phosphoinositide 3-kinase gamma-deficient mice are protected from isoproterenol-induced heart failure. Circulation. 108: 2147-52. PMID 12963636 DOI: 10.1161/01.Cir.0000091403.62293.2B  0.56
2003 Oudit GY, Sun H, Trivieri MG, Koch SE, Dawood F, Ackerley C, Yazdanpanah M, Wilson GJ, Schwartz A, Liu PP, Backx PH. L-type Ca2+ channels provide a major pathway for iron entry into cardiomyocytes in iron-overload cardiomyopathy. Nature Medicine. 9: 1187-94. PMID 12937413 DOI: 10.1038/Nm920  0.64
2003 Vanderlaan RD, Oudit GY, Backx PH. Electrophysiological profiling of cardiomyocytes in embryonic bodies derived from human embryonic stem cells: therapeutic implications. Circulation Research. 93: 1-3. PMID 12855668 DOI: 10.1161/01.Res.0000082767.38055.03  0.56
2003 Zobel C, Cho HC, Nguyen TT, Pekhletski R, Diaz RJ, Wilson GJ, Backx PH. Molecular dissection of the inward rectifier potassium current (IK1) in rabbit cardiomyocytes: evidence for heteromeric co-assembly of Kir2.1 and Kir2.2. The Journal of Physiology. 550: 365-72. PMID 12794173 DOI: 10.1113/Jphysiol.2002.036400  0.72
2003 Oudit GY, Crackower MA, Backx PH, Penninger JM. The role of ACE2 in cardiovascular physiology. Trends in Cardiovascular Medicine. 13: 93-101. PMID 12691672 DOI: 10.1016/S1050-1738(02)00233-5  0.56
2003 Diaz RJ, Armstrong SC, Batthish M, Backx PH, Ganote CE, Wilson GJ. Enhanced cell volume regulation: a key protective mechanism of ischemic preconditioning in rabbit ventricular myocytes. Journal of Molecular and Cellular Cardiology. 35: 45-58. PMID 12623299 DOI: 10.1016/S0022-2828(02)00277-8  0.36
2003 Oudit GY, Trivieri MG, Backx PH. Sulfhydryl modulation of K+ currents: a possible cross-link between oxidative stress and altered cardiovascular function. Journal of Molecular and Cellular Cardiology. 35: 1-4. PMID 12623295 DOI: 10.1016/S0022-2828(02)00285-7  0.56
2003 Sah R, Ramirez RJ, Oudit GY, Gidrewicz D, Trivieri MG, Zobel C, Backx PH. Regulation of cardiac excitation-contraction coupling by action potential repolarization: role of the transient outward potassium current (I(to)). The Journal of Physiology. 546: 5-18. PMID 12509475 DOI: 10.1113/Jphysiol.2002.026468  0.6
2002 Zobel C, Kassiri Z, Nguyen TT, Meng Y, Backx PH. Prevention of hypertrophy by overexpression of Kv4.2 in cultured neonatal cardiomyocytes. Circulation. 106: 2385-91. PMID 12403671 DOI: 10.1161/01.Cir.0000033970.22130.93  0.64
2002 Crackower MA, Oudit GY, Kozieradzki I, Sarao R, Sun H, Sasaki T, Hirsch E, Suzuki A, Shioi T, Irie-Sasaki J, Sah R, Cheng HY, Rybin VO, Lembo G, Fratta L, ... ... Backx PH, et al. Regulation of myocardial contractility and cell size by distinct PI3K-PTEN signaling pathways. Cell. 110: 737-49. PMID 12297047 DOI: 10.1016/S0092-8674(02)00969-8  0.6
2002 Kaprielian R, Sah R, Nguyen T, Wickenden AD, Backx PH. Myocardial infarction in rat eliminates regional heterogeneity of AP profiles, I(to) K(+) currents, and [Ca(2+)](i) transients. American Journal of Physiology. Heart and Circulatory Physiology. 283: H1157-68. PMID 12181147 DOI: 10.1152/Ajpheart.00518.2001  0.64
2002 Batthish M, Diaz RJ, Zeng HP, Backx PH, Wilson GJ. Pharmacological preconditioning in rabbit myocardium is blocked by chloride channel inhibition. Cardiovascular Research. 55: 660-71. PMID 12160963 DOI: 10.1016/S0008-6363(02)00454-6  0.36
2002 Crackower MA, Sarao R, Oudit GY, Yagil C, Kozieradzki I, Scanga SE, Oliveira-dos-Santos AJ, da Costa J, Zhang L, Pei Y, Scholey J, Ferrario CM, Manoukian AS, Chappell MC, Backx PH, et al. Angiotensin-converting enzyme 2 is an essential regulator of heart function. Nature. 417: 822-8. PMID 12075344 DOI: 10.1038/Nature00786  0.64
2002 Kassiri Z, Hajjar R, Backx PH. Molecular components of transient outward potassium current in cultured neonatal rat ventricular myocytes. Journal of Molecular Medicine (Berlin, Germany). 80: 351-8. PMID 12072910 DOI: 10.1007/S00109-002-0325-7  0.64
2002 Sah R, Oudit GY, Nguyen TT, Lim HW, Wickenden AD, Wilson GJ, Molkentin JD, Backx PH. Inhibition of calcineurin and sarcolemmal Ca2+ influx protects cardiac morphology and ventricular function in K(v)4.2N transgenic mice. Circulation. 105: 1850-6. PMID 11956130 DOI: 10.1161/01.Cir.0000014211.47830.4D  0.6
2002 Kassiri Z, Zobel C, Nguyen TT, Molkentin JD, Backx PH. Reduction of I(to) causes hypertrophy in neonatal rat ventricular myocytes. Circulation Research. 90: 578-85. PMID 11909822 DOI: 10.1161/01.Res.0000012223.86441.A1  0.64
2002 Sah R, Ramirez RJ, Backx PH. Modulation of Ca(2+) release in cardiac myocytes by changes in repolarization rate: role of phase-1 action potential repolarization in excitation-contraction coupling. Circulation Research. 90: 165-73. PMID 11834709 DOI: 10.1161/Hh0202.103315  0.6
2002 Edwards L, Nashmi R, Jones O, Backx P, Ackerley C, Becker L, Fehlings MG. Upregulation of Kv 1.4 protein and gene expression after chronic spinal cord injury. The Journal of Comparative Neurology. 443: 154-67. PMID 11793353 DOI: 10.1002/Cne.10115  0.64
2001 Nishiyama A, Ishii DN, Backx PH, Pulford BE, Birks BR, Tamkun MM. Altered K(+) channel gene expression in diabetic rat ventricle: isoform switching between Kv4.2 and Kv1.4. American Journal of Physiology. Heart and Circulatory Physiology. 281: H1800-7. PMID 11557574 DOI: 10.1152/Ajpheart.2001.281.4.H1800  0.64
2001 Macdonald PE, Ha XF, Wang J, Smukler SR, Sun AM, Gaisano HY, Salapatek AMF, Backx PH, Wheeler MB. Members of the Kv1 and Kv2 voltage-dependent K+ channel families regulate insulin secretion Molecular Endocrinology. 15: 1423-1435. PMID 11463864 DOI: 10.1210/Mend.15.8.0685  0.64
2001 Sah R, Ramirez RJ, Kaprielian R, Backx PH. Alterations in action potential profile enhance excitation-contraction coupling in rat cardiac myocytes. The Journal of Physiology. 533: 201-14. PMID 11351028 DOI: 10.1111/J.1469-7793.2001.0201B.X  0.64
2001 Oudit GY, Kassiri Z, Sah R, Ramirez RJ, Zobel C, Backx PH. The molecular physiology of the cardiac transient outward potassium current (I(to)) in normal and diseased myocardium. Journal of Molecular and Cellular Cardiology. 33: 851-72. PMID 11343410 DOI: 10.1006/Jmcc.2001.1376  0.64
2000 Zvaritch E, Backx PH, Jirik F, Kimura Y, de Leon S, Schmidt AG, Hoit BD, Lester JW, Kranias EG, MacLennan DH. The transgenic expression of highly inhibitory monomeric forms of phospholamban in mouse heart impairs cardiac contractility. The Journal of Biological Chemistry. 275: 14985-91. PMID 10809743 DOI: 10.1074/Jbc.275.20.14985  0.64
2000 Wickenden AD, Kaprielian R, You XM, Backx PH. The thyroid hormone analog DITPA restores I(to) in rats after myocardial infarction. American Journal of Physiology. Heart and Circulatory Physiology. 278: H1105-16. PMID 10749704 DOI: 10.1152/Ajpheart.2000.278.4.H1105  0.64
2000 Kassiri Z, Myers R, Kaprielian R, Banijamali HS, Backx PH. Rate-dependent changes of twitch force duration in rat cardiac trabeculae: a property of the contractile system. The Journal of Physiology. 524: 221-31. PMID 10747194 DOI: 10.1111/J.1469-7793.2000.T01-3-00221.X  0.64
1999 Bartfay WJ, Dawood F, Wen WH, Lehotay DC, Hou D, Bartfay E, Luo X, Backx PH, Liu PP. Cardiac function and cytotoxic aldehyde production in a murine model of chronic iron-overload. Cardiovascular Research. 43: 892-900. PMID 10615416 DOI: 10.1016/S0008-6363(99)00040-1  0.44
1999 Wickenden AD, Lee P, Sah R, Huang Q, Fishman GI, Backx PH. Targeted expression of a dominant-negative K(v)4.2 K(+) channel subunit in the mouse heart. Circulation Research. 85: 1067-76. PMID 10571538 DOI: 10.1161/01.Res.85.11.1067  0.6
1999 Wickenden AD, Tsushima RG, Losito VA, Kaprielian R, Backx PH. Effect of Cd2+ on Kv4.2 and Kv1.4 expressed in Xenopus oocytes and on the transient outward currents in rat and rabbit ventricular myocytes. Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology. 9: 11-28. PMID 10352341 DOI: 10.1159/000016299  0.64
1999 Wickenden AD, Jegla TJ, Kaprielian R, Backx PH. Regional contributions of Kv1.4, Kv4.2, and Kv4.3 to transient outward K+ current in rat ventricle. The American Journal of Physiology. 276: H1599-607. PMID 10330244 DOI: 10.1152/Ajpheart.1999.276.5.H1599  0.64
1999 Kaprielian R, Wickenden AD, Kassiri Z, Parker TG, Liu PP, Backx PH. Relationship between K+ channel down-regulation and [Ca2+]i in rat ventricular myocytes following myocardial infarction. The Journal of Physiology. 517: 229-45. PMID 10226162 DOI: 10.1111/J.1469-7793.1999.0229Z.X  0.64
1998 Sah RL, Tsushima RG, Backx PH. Effects of local anesthetics on Nachannels containing the equine hyperkalemic periodic paralysis mutation. American Journal of Physiology. Cell Physiology. 275: C389-C400. PMID 29585668 DOI: 10.1152/ajpcell.1998.275.2.C389  0.64
1998 Sah RL, Tsushima RG, Backx PH. Effects of local anesthetics on Na+ channels containing the equine hyperkalemic periodic paralysis mutation. The American Journal of Physiology. 275: C389-400. PMID 9688593 DOI: 10.1152/Ajpcell.1998.275.2.C389  0.64
1998 Wickenden AD, Kaprielian R, Kassiri Z, Tsoporis JN, Tsushima R, Fishman GI, Backx PH. The role of action potential prolongation and altered intracellular calcium handling in the pathogenesis of heart failure. Cardiovascular Research. 37: 312-23. PMID 9614488 DOI: 10.1016/S0008-6363(97)00256-3  0.64
1997 Wickenden AD, Kaprielian R, Parker TG, Jones OT, Backx PH. Effects of development and thyroid hormone on K+ currents and K+ channel gene expression in rat ventricle. The Journal of Physiology. 504: 271-86. PMID 9365903 DOI: 10.1111/J.1469-7793.1997.271Be.X  0.64
1996 Hanna WJ, Tsushima RG, Sah R, McCutcheon LJ, Marban E, Backx PH. The equine periodic paralysis Na+ channel mutation alters molecular transitions between the open and inactivated states. The Journal of Physiology. 497: 349-64. PMID 8961180  0.64
1995 Dobrunz LE, Backx PH, Yue DT. Steady-state [Ca2+]i-force relationship in intact twitching cardiac muscle: direct evidence for modulation by isoproterenol and EMD 53998. Biophysical Journal. 69: 189-201. PMID 7669896 DOI: 10.1016/S0006-3495(95)79889-7  0.64
1995 Tomaselli GF, Chiamvimonvat N, Nuss HB, Balser JR, Perez-Garcia MT, Ruo Hui Xu, Orias DW, Backx PH, Marban E. A mutation in the pore of the sodium channel alters gating Biophysical Journal. 68: 1814-1827. PMID 7612823 DOI: 10.1016/S0006-3495(95)80358-9  0.64
1992 Backx PH, Yue DT, Lawrence JH, Marban E, Tomaselli GF. Molecular localization of an ion-binding site within the pore of mammalian sodium channels. Science (New York, N.Y.). 257: 248-51. PMID 1321496 DOI: 10.1126/Science.1321496  0.64
1991 Ter Keurs HEDJ, De Tombe PP, Backx PHM, Iwazumi T. Rheology of myocardium. The relation between force, velocity, sarcomere length and activation in rat cardiac muscle Biorheology. 28: 161-170. PMID 1932708  0.64
1990 Yue DT, Backx PH, Imredy JP. Calcium-sensitive inactivation in the gating of single calcium channels. Science (New York, N.Y.). 250: 1735-8. PMID 2176745 DOI: 10.1126/Science.2176745  0.64
1989 Backx PH, De Tombe PP, Van Deen JHK, Mulder BJM, Ter Keurs HEDJ. A model of propagating calcium-induced calcium release mediated by calcium diffusion Journal of General Physiology. 93: 963-977. PMID 2738577  0.64
1988 Ter Keurs HEDJ, Backx PH, De Tombe PP, Mulder BJ. Aftercontractions and excitation-contraction coupling in rat cardiac muscle Canadian Journal of Physiology and Pharmacology. 66: 1239-1245. PMID 3219666 DOI: 10.1139/Y88-204  0.64
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