| Year |
Citation |
Score |
| 2022 |
Teng ACT, Gu L, Di Paola M, Lakin R, Williams ZJ, Au A, Chen W, Callaghan NI, Zadeh FH, Zhou YQ, Fatah M, Chatterjee D, Jourdan LJ, Liu J, Simmons CA, ... ... Backx PH, et al. Tmem65 is critical for the structure and function of the intercalated discs in mouse hearts. Nature Communications. 13: 6166. PMID 36257954 DOI: 10.1038/s41467-022-33303-y |
0.337 |
|
| 2022 |
Kim KH, Oh Y, Liu J, Dababneh S, Xia Y, Kim RY, Kim DK, Ban K, Husain M, Hui CC, Backx PH. Irx5 and transient outward K currents contribute to transmural contractile heterogeneities in the mouse ventricle. American Journal of Physiology. Heart and Circulatory Physiology. 322: H725-H741. PMID 35245131 DOI: 10.1152/ajpheart.00572.2021 |
0.751 |
|
| 2021 |
Kim KH, Backx PH. Understanding the Role of Iroquois Homeobox Transcription Factor 5 (IRX5) in Cardiac Function: Getting to the (Human) Heart of the Matter. Cardiovascular Research. PMID 33739382 DOI: 10.1093/cvr/cvab098 |
0.709 |
|
| 2020 |
Oh Y, Yang S, Liu X, Jana S, Izaddoustdar F, Gao X, Debi R, Kim DK, Kim KH, Yang P, Kassiri Z, Lakin R, Backx PH. Transcriptomic Bioinformatic Analyses of Atria Uncover Involvement of Pathways Related to Strain and Post-translational Modification of Collagen in Increased Atrial Fibrillation Vulnerability in Intensely Exercised Mice. Frontiers in Physiology. 11: 605671. PMID 33424629 DOI: 10.3389/fphys.2020.605671 |
0.746 |
|
| 2019 |
Polidovitch N, Yang S, Sun H, Lakin R, Ahmad F, Gao X, Turnbull PC, Chiarello C, Perry CGR, Manganiello V, Yang P, Backx PH. Phosphodiesterase type 3A (PDE3A), but not type 3B (PDE3B), contributes to the adverse cardiac remodeling induced by pressure overload. Journal of Molecular and Cellular Cardiology. PMID 31051182 DOI: 10.1016/j.yjmcc.2019.04.028 |
0.318 |
|
| 2018 |
Sadi AM, Afroze T, Siraj MA, Momen A, White-Dzuro C, Zarrin-Khat D, Handa S, Ban K, Kabir MG, Trivieri MG, Gros R, Backx P, Husain M. Cardiac-specific inducible over-expression of human Plasma Membrane CaATPase 4b is cardioprotective and improves survival in mice following ischemic injury. Clinical Science (London, England : 1979). PMID 29487197 DOI: 10.1042/Cs20171337 |
0.344 |
|
| 2017 |
Yin JC, Platt MJ, Tian X, Wu X, Backx PH, Simpson JA, Araki T, Neel BG. Cellular interplay via cytokine hierarchy causes pathological cardiac hypertrophy in RAF1-mutant Noonan syndrome. Nature Communications. 8: 15518. PMID 28548091 DOI: 10.1038/ncomms15518 |
0.313 |
|
| 2017 |
Huang J, Wu J, Wang S, You J, Ye Y, Ding Z, Yang F, Wang X, Guo J, Ma L, Yuan J, Shen Y, Yang X, Sun A, Jiang H, ... ... Backx PH, et al. Ultrasound Biomicroscopy Validation of a Murine Model of Cardiac Hypertrophic Preconditioning: Comparison with a Hemodynamic Assessment. American Journal of Physiology. Heart and Circulatory Physiology. ajpheart.00004.2017. PMID 28455286 DOI: 10.1152/Ajpheart.00004.2017 |
0.341 |
|
| 2016 |
Kim KH, Rosen A, Hussein SM, Puviindran V, Korogyi AS, Chiarello C, Nagy A, Hui CC, Backx PH. Irx3 is required for postnatal maturation of the mouse ventricular conduction system. Scientific Reports. 6: 19197. PMID 26786475 DOI: 10.1038/Srep19197 |
0.724 |
|
| 2016 |
Cordeiro JM, Calloe K, Aschar-Sobbi R, Kim KH, Korogyi A, Occhipinti D, Backx PH, Panama BK. Physiological roles of the transient outward current Ito in normal and diseased hearts. Frontiers in Bioscience (Scholar Edition). 8: 143-59. PMID 26709904 DOI: 10.2741/S454 |
0.744 |
|
| 2015 |
Liu J, Kim KH, Morales MJ, Heximer SP, Hui CC, Backx PH. Kv4.3-Encoded Fast Transient Outward Current Is Presented in Kv4.2 Knockout Mouse Cardiomyocytes. Plos One. 10: e0133274. PMID 26196737 DOI: 10.1371/Journal.Pone.0133274 |
0.729 |
|
| 2015 |
Dadson K, Turdi S, Hashemi S, Zhao J, Polidovitch N, Beca S, Backx PH, McDermott JC, Sweeney G. Adiponectin is required for cardiac MEF2 activation during pressure overload induced hypertrophy. Journal of Molecular and Cellular Cardiology. 86: 102-9. PMID 26196305 DOI: 10.1016/J.Yjmcc.2015.06.020 |
0.386 |
|
| 2015 |
Aschar-Sobbi R, Izaddoustdar F, Korogyi AS, Wang Q, Farman GP, Yang F, Yang W, Dorian D, Simpson JA, Tuomi JM, Jones DL, Nanthakumar K, Cox B, Wehrens XH, Dorian P, ... Backx PH, et al. Increased atrial arrhythmia susceptibility induced by intense endurance exercise in mice requires TNFα. Nature Communications. 6: 6018. PMID 25598495 DOI: 10.1038/Ncomms7018 |
0.305 |
|
| 2015 |
Song Z, Adam K, Backx PH, Qu Z. Subcellular Ca Channel Distribution and Ca Alternans in Atrial Myocytes Biophysical Journal. 108: 261a. DOI: 10.1016/J.Bpj.2014.11.1444 |
0.38 |
|
| 2014 |
Wang DY, Abbasi C, El-Rass S, Li JY, Dawood F, Naito K, Sharma P, Bousette N, Singh S, Backx PH, Cox B, Wen XY, Liu PP, Gramolini AO. Endoplasmic reticulum resident protein 44 (ERp44) deficiency in mice and zebrafish leads to cardiac developmental and functional defects. Journal of the American Heart Association. 3: e001018. PMID 25332179 DOI: 10.1161/Jaha.114.001018 |
0.381 |
|
| 2014 |
Backx PH. Complexity, confusion and controversy continue complicating the contribution of RyR2 channel phosphorylation to heart function. The Journal of Physiology. 592: 1911-2. PMID 24786150 DOI: 10.1113/Jphysiol.2014.272575 |
0.426 |
|
| 2014 |
Diaz RJ, Harvey K, Boloorchi A, Hossain T, Hinek A, Backx PH, Wilson GJ. Enhanced cell volume regulation: a key mechanism in local and remote ischemic preconditioning. American Journal of Physiology. Cell Physiology. 306: C1191-9. PMID 24760980 DOI: 10.1152/Ajpcell.00259.2013 |
0.349 |
|
| 2014 |
Vanderlaan RD, Caldarone CA, Backx PH. Heart failure in congenital heart disease: the role of genes and hemodynamics. PflüGers Archiv : European Journal of Physiology. 466: 1025-35. PMID 24488006 DOI: 10.1007/S00424-014-1447-9 |
0.353 |
|
| 2014 |
Zamiri N, Massé S, Ramadeen A, Kusha M, Hu X, Azam MA, Liu J, Lai PF, Vigmond EJ, Boyle PM, Behradfar E, Al-Hesayen A, Waxman MB, Backx P, Dorian P, et al. Dantrolene improves survival after ventricular fibrillation by mitigating impaired calcium handling in animal models. Circulation. 129: 875-85. PMID 24403563 DOI: 10.1161/Circulationaha.113.005443 |
0.336 |
|
| 2014 |
Liang W, Huang L, Zhao D, He JZ, Sharma P, Liu J, Gramolini AO, Ward ME, Cho HC, Backx PH. Swelling-activated Cl- currents and intracellular CLC-3 are involved in proliferation of human pulmonary artery smooth muscle cells. Journal of Hypertension. 32: 318-30. PMID 24284495 DOI: 10.1097/Hjh.0000000000000013 |
0.519 |
|
| 2013 |
Strandberg LS, Cui X, Rath A, Liu J, Silverman ED, Liu X, Siragam V, Ackerley C, Su BB, Yan JY, Capecchi M, Biavati L, Accorroni A, Yuen W, Quattrone F, ... ... Backx PH, et al. Congenital heart block maternal sera autoantibodies target an extracellular epitope on the α1G T-type calcium channel in human fetal hearts. Plos One. 8: e72668. PMID 24039792 DOI: 10.1371/Journal.Pone.0072668 |
0.322 |
|
| 2013 |
Kelsey L, Flenniken AM, Qu D, Funnell AP, Pearson R, Zhou YQ, Voronina I, Berberovic Z, Wood G, Newbigging S, Weiss ES, Wong M, Quach I, Yeh SY, Deshwar AR, ... ... Backx P, et al. ENU-induced mutation in the DNA-binding domain of KLF3 reveals important roles for KLF3 in cardiovascular development and function in mice. Plos Genetics. 9: e1003612. PMID 23874215 DOI: 10.1371/Journal.Pgen.1003612 |
0.368 |
|
| 2013 |
Nunes SS, Miklas JW, Liu J, Aschar-Sobbi R, Xiao Y, Zhang B, Jiang J, Massé S, Gagliardi M, Hsieh A, Thavandiran N, Laflamme MA, Nanthakumar K, Gross GJ, Backx PH, et al. Biowire: a platform for maturation of human pluripotent stem cell-derived cardiomyocytes. Nature Methods. 10: 781-7. PMID 23793239 DOI: 10.1038/Nmeth.2524 |
0.313 |
|
| 2013 |
Kim M, Platt MJ, Shibasaki T, Quaggin SE, Backx PH, Seino S, Simpson JA, Drucker DJ. GLP-1 receptor activation and Epac2 link atrial natriuretic peptide secretion to control of blood pressure. Nature Medicine. 19: 567-75. PMID 23542788 DOI: 10.1038/Nm.3128 |
0.324 |
|
| 2013 |
Jadhav A, Liang W, Papageorgiou PC, Shoker A, Kanthan SC, Balsevich J, Levy AS, Heximer S, Backx PH, Gopalakrishnan V. Catharanthine dilates small mesenteric arteries and decreases heart rate and cardiac contractility by inhibition of voltage-operated calcium channels on vascular smooth muscle cells and cardiomyocytes. The Journal of Pharmacology and Experimental Therapeutics. 345: 383-92. PMID 23532933 DOI: 10.1124/Jpet.112.199661 |
0.585 |
|
| 2013 |
Beca S, Ahmad F, Shen W, Liu J, Makary S, Polidovitch N, Sun J, Hockman S, Chung YW, Movsesian M, Murphy E, Manganiello V, Backx PH. Phosphodiesterase type 3A regulates basal myocardial contractility through interacting with sarcoplasmic reticulum calcium ATPase type 2a signaling complexes in mouse heart. Circulation Research. 112: 289-97. PMID 23168336 DOI: 10.1161/Circresaha.111.300003 |
0.363 |
|
| 2012 |
Backx PH. Could plugging the oxidation-mediated Ca2+ leak stem the tide of the atrial fibrillation epidemic? Circulation Research. 111: 662-5. PMID 22935529 DOI: 10.1161/Circresaha.112.275453 |
0.316 |
|
| 2012 |
Wu X, Yin J, Simpson J, Kim KH, Gu S, Hong JH, Bayliss P, Backx PH, Neel BG, Araki T. Increased BRAF heterodimerization is the common pathogenic mechanism for noonan syndrome-associated RAF1 mutants. Molecular and Cellular Biology. 32: 3872-90. PMID 22826437 DOI: 10.1128/Mcb.00751-12 |
0.704 |
|
| 2012 |
Kim KH, Rosen A, Bruneau BG, Hui CC, Backx PH. Iroquois homeodomain transcription factors in heart development and function. Circulation Research. 110: 1513-24. PMID 22628575 DOI: 10.1161/Circresaha.112.265041 |
0.742 |
|
| 2012 |
Degousee N, Simpson J, Fazel S, Scholich K, Angoulvant D, Angioni C, Schmidt H, Korotkova M, Stefanski E, Wang XH, Lindsay TF, Ofek E, Pierre S, Butany J, Jakobsson PJ, ... ... Backx PH, et al. Lack of microsomal prostaglandin E(2) synthase-1 in bone marrow-derived myeloid cells impairs left ventricular function and increases mortality after acute myocardial infarction. Circulation. 125: 2904-13. PMID 22589381 DOI: 10.1161/Circulationaha.112.099754 |
0.356 |
|
| 2012 |
Jadhav A, Liang W, Balsevich J, Bastin G, Kroetsch J, Heximer S, Backx PH, Gopalakrishnan V. L-tryptophan ethyl ester dilates small mesenteric arteries by inhibition of voltage-operated calcium channels in smooth muscle. British Journal of Pharmacology. 166: 232-42. PMID 21951131 DOI: 10.1111/J.1476-5381.2011.01693.X |
0.512 |
|
| 2012 |
Abbasi C, Wang D, El-Rass S, Li J, Backx P, Cox B, Wen X, Gramolini A. 375 ERp44 Expression During Zebrafish and Mouse Embryogenesis and Heart Development Canadian Journal of Cardiology. 28: S238-S239. DOI: 10.1016/J.Cjca.2012.07.353 |
0.348 |
|
| 2011 |
Beca S, Aschars-Sobbi R, Panama BK, Backx PH. Regulation of murine cardiac function by phosphodiesterases type 3 and 4. Current Opinion in Pharmacology. 11: 714-9. PMID 22047792 DOI: 10.1016/J.Coph.2011.10.017 |
0.376 |
|
| 2011 |
Kim JI, Lee HR, Sim SE, Baek J, Yu NK, Choi JH, Ko HG, Lee YS, Park SW, Kwak C, Ahn SJ, Choi SY, Kim H, Kim KH, Backx PH, et al. PI3Kγ is required for NMDA receptor-dependent long-term depression and behavioral flexibility. Nature Neuroscience. 14: 1447-54. PMID 22019731 DOI: 10.1038/Nn.2937 |
0.669 |
|
| 2011 |
Beca S, Helli PB, Simpson JA, Zhao D, Farman GP, Jones PP, Tian X, Wilson LS, Ahmad F, Chen SR, Movsesian MA, Manganiello V, Maurice DH, Conti M, Backx PH. Phosphodiesterase 4D regulates baseline sarcoplasmic reticulum Ca2+ release and cardiac contractility, independently of L-type Ca2+ current. Circulation Research. 109: 1024-30. PMID 21903937 DOI: 10.1161/Circresaha.111.250464 |
0.421 |
|
| 2011 |
Zhang SS, Kim KH, Rosen A, Smyth JW, Sakuma R, Delgado-OlguÃn P, Davis M, Chi NC, Puviindran V, Gaborit N, Sukonnik T, Wylie JN, Brand-Arzamendi K, Farman GP, Kim J, ... ... Backx PH, et al. Iroquois homeobox gene 3 establishes fast conduction in the cardiac His-Purkinje network. Proceedings of the National Academy of Sciences of the United States of America. 108: 13576-81. PMID 21825130 DOI: 10.1073/Pnas.1106911108 |
0.721 |
|
| 2011 |
Ramirez RJ, Sah R, Liu J, Rose RA, Backx PH. Intracellular [Na(+)] modulates synergy between Na(+)/Ca (2+) exchanger and L-type Ca (2+) current in cardiac excitation-contraction coupling during action potentials. Basic Research in Cardiology. 106: 967-77. PMID 21779914 DOI: 10.1007/S00395-011-0202-Z |
0.76 |
|
| 2011 |
Rose RA, Sellan M, Simpson JA, Izaddoustdar F, Cifelli C, Panama BK, Davis M, Zhao D, Markhani M, Murphy GG, Striessnig J, Liu PP, Heximer SP, Backx PH. Iron overload decreases CaV1.3-dependent L-type Ca2+ currents leading to bradycardia, altered electrical conduction, and atrial fibrillation. Circulation. Arrhythmia and Electrophysiology. 4: 733-42. PMID 21747058 DOI: 10.1161/Circep.110.960401 |
0.435 |
|
| 2011 |
Tupling AR, Bombardier E, Gupta SC, Hussain D, Vigna C, Bloemberg D, Quadrilatero J, Trivieri MG, Babu GJ, Backx PH, Periasamy M, MacLennan DH, Gramolini AO. Enhanced Ca2+ transport and muscle relaxation in skeletal muscle from sarcolipin-null mice. American Journal of Physiology. Cell Physiology. 301: C841-9. PMID 21697544 DOI: 10.1152/Ajpcell.00409.2010 |
0.321 |
|
| 2011 |
Martino TA, Tata N, Simpson JA, Vanderlaan R, Dawood F, Kabir MG, Khaper N, Cifelli C, Podobed P, Liu PP, Husain M, Heximer S, Backx PH, Sole MJ. The primary benefits of angiotensin-converting enzyme inhibition on cardiac remodeling occur during sleep time in murine pressure overload hypertrophy. Journal of the American College of Cardiology. 57: 2020-8. PMID 21565639 DOI: 10.1016/J.Jacc.2010.11.022 |
0.307 |
|
| 2011 |
Backx PH. Serving up the ping-pong mechanisms for biventricular ventricular tachycardia. Heart Rhythm : the Official Journal of the Heart Rhythm Society. 8: 606-7. PMID 21354333 DOI: 10.1016/J.Hrthm.2011.02.031 |
0.324 |
|
| 2011 |
Wu X, Simpson J, Hong JH, Kim KH, Thavarajah NK, Backx PH, Neel BG, Araki T. MEK-ERK pathway modulation ameliorates disease phenotypes in a mouse model of Noonan syndrome associated with the Raf1(L613V) mutation. The Journal of Clinical Investigation. 121: 1009-25. PMID 21339642 DOI: 10.1172/Jci44929 |
0.713 |
|
| 2011 |
Liu J, Kim KH, London B, Morales MJ, Backx PH. Dissection of the voltage-activated potassium outward currents in adult mouse ventricular myocytes: I(to,f), I(to,s), I(K,slow1), I(K,slow2), and I(ss). Basic Research in Cardiology. 106: 189-204. PMID 21253754 DOI: 10.1007/S00395-010-0134-Z |
0.725 |
|
| 2011 |
Panama BK, Latour-Villamil D, Farman GP, Zhao D, Bolz SS, Kirshenbaum LA, Backx PH. Nuclear factor kappaB downregulates the transient outward potassium current I(to,f) through control of KChIP2 expression. Circulation Research. 108: 537-43. PMID 21252158 DOI: 10.1161/Circresaha.110.229112 |
0.329 |
|
| 2011 |
Ye L, Zhu W, Backx PH, Cortez MA, Wu J, Chow YH, McKerlie C, Wang A, Tsui LC, Gross GJ, Hu J. Arrhythmia and sudden death associated with elevated cardiac chloride channel activity. Journal of Cellular and Molecular Medicine. 15: 2307-16. PMID 21155978 DOI: 10.1111/J.1582-4934.2010.01243.X |
0.421 |
|
| 2011 |
Vanderlaan RD, Hardy WR, Kabir MG, Pasculescu A, Jones N, deTombe PP, Backx PH, Pawson T. The ShcA phosphotyrosine docking protein uses distinct mechanisms to regulate myocyte and global heart function. Circulation Research. 108: 184-93. PMID 21148430 DOI: 10.1161/Circresaha.110.233924 |
0.344 |
|
| 2011 |
Li J, Xuan W, Yan R, Tropak MB, Jean-St-Michel E, Liang W, Gladstone R, Backx PH, Kharbanda RK, Redington AN. Remote preconditioning provides potent cardioprotection via PI3K/Akt activation and is associated with nuclear accumulation of β-catenin. Clinical Science (London, England : 1979). 120: 451-62. PMID 21143191 DOI: 10.1042/Cs20100466 |
0.543 |
|
| 2011 |
Mueller EE, Momen A, Massé S, Zhou YQ, Liu J, Backx PH, Henkelman RM, Nanthakumar K, Stewart DJ, Husain M. Electrical remodelling precedes heart failure in an endothelin-1-induced model of cardiomyopathy. Cardiovascular Research. 89: 623-33. PMID 21062919 DOI: 10.1093/Cvr/Cvq351 |
0.373 |
|
| 2011 |
Panama B, Lai P, Massé S, Li G, Zhang Y, Kusha M, Asta J, Farid T, Backx P, Yau T, Nanthakumar K. 685 Anti-arrhythmic cell therapy for the failing heart: Mesenchymal stem cell transplantation mitigates electrophysiological remodelling in a rat model of myocardial infarction Canadian Journal of Cardiology. 27: S312-S313. DOI: 10.1016/J.Cjca.2011.07.570 |
0.302 |
|
| 2011 |
Sharma P, Bousette N, Ignatchenko A, Noronha M, Ignatchenko V, Dubois N, Miyake T, Liu J, Hamilton R, Backx P, Keller G, Kislinger T, Gramolini A. 280 Proteomic profiling of mouse and human cardiac membrane proteins reveals novel cardiac proteins Canadian Journal of Cardiology. 27: S163. DOI: 10.1016/J.Cjca.2011.07.208 |
0.336 |
|
| 2010 |
Farman GP, Allen EJ, Schoenfelt KQ, Backx PH, de Tombe PP. The role of thin filament cooperativity in cardiac length-dependent calcium activation. Biophysical Journal. 99: 2978-86. PMID 21044595 DOI: 10.1016/J.Bpj.2010.09.003 |
0.61 |
|
| 2010 |
Bousette N, Chugh S, Fong V, Isserlin R, Kim KH, Volchuk A, Backx PH, Liu P, Kislinger T, MacLennan DH, Emili A, Gramolini AO. Constitutively active calcineurin induces cardiac endoplasmic reticulum stress and protects against apoptosis that is mediated by alpha-crystallin-B. Proceedings of the National Academy of Sciences of the United States of America. 107: 18481-6. PMID 20937869 DOI: 10.1073/Pnas.1013555107 |
0.737 |
|
| 2010 |
Guo D, Kassiri Z, Basu R, Chow FL, Kandalam V, Damilano F, Liang W, Izumo S, Hirsch E, Penninger JM, Backx PH, Oudit GY. Loss of PI3Kγ enhances cAMP-dependent MMP remodeling of the myocardial N-cadherin adhesion complexes and extracellular matrix in response to early biomechanical stress. Circulation Research. 107: 1275-89. PMID 20847309 DOI: 10.1161/Circresaha.110.229054 |
0.677 |
|
| 2010 |
Liang W, Oudit GY, Patel MM, Shah AM, Woodgett JR, Tsushima RG, Ward ME, Backx PH. Role of phosphoinositide 3-kinase {alpha}, protein kinase C, and L-type Ca2+ channels in mediating the complex actions of angiotensin II on mouse cardiac contractility. Hypertension. 56: 422-9. PMID 20696985 DOI: 10.1161/Hypertensionaha.109.149344 |
0.586 |
|
| 2010 |
Ban K, Kim KH, Cho CK, Sauvé M, Diamandis EP, Backx PH, Drucker DJ, Husain M. Glucagon-like peptide (GLP)-1(9-36)amide-mediated cytoprotection is blocked by exendin(9-39) yet does not require the known GLP-1 receptor. Endocrinology. 151: 1520-31. PMID 20172966 DOI: 10.1210/En.2009-1197 |
0.712 |
|
| 2010 |
Papp S, Dziak E, Kabir G, Backx P, Clement S, Opas M. Evidence for calreticulin attenuation of cardiac hypertrophy induced by pressure overload and soluble agonists. The American Journal of Pathology. 176: 1113-21. PMID 20110410 DOI: 10.2353/Ajpath.2010.090392 |
0.423 |
|
| 2010 |
Farman GP, Helli PB, Backx PH. Differential Regulation of β-Adrenergic Signaling Via Phosphoinositide-3-Kinase-γ Biophysical Journal. 98: 99a. DOI: 10.1016/J.Bpj.2009.12.557 |
0.338 |
|
| 2010 |
Panama BK, Latour D, Kirshenbaum L, Bolz S, Backx PH. Regulation of the Transient Outward Potassium Current Itof in Cardiac Hypertrophy by Sphingosine-1-Phosphate Signaling Biophysical Journal. 98: 531a-532a. DOI: 10.1016/J.Bpj.2009.12.2884 |
0.337 |
|
| 2009 |
D'Avanzo N, Pekhletski R, Backx PH. P-loop residues critical for selectivity in K channels fail to confer selectivity to rabbit HCN4 channels. Plos One. 4: e7712. PMID 19890386 DOI: 10.1371/Journal.Pone.0007712 |
0.688 |
|
| 2009 |
Liang W, Ray JB, He JZ, Backx PH, Ward ME. Regulation of proliferation and membrane potential by chloride currents in rat pulmonary artery smooth muscle cells. Hypertension. 54: 286-93. PMID 19581510 DOI: 10.1161/Hypertensionaha.109.130138 |
0.563 |
|
| 2009 |
Farman GP, Allen EJ, Schoenfelt KQ, Gore D, Backx PH, Irving TC, de Pieter Tombe P. Changes in Thick Filament Structure of Isolated Intact Rat Cardiac Muscle During Contraction Determined by 2-D X-ray Diffraction Analysis Biophysical Journal. 96: 619a. DOI: 10.1016/J.Bpj.2008.12.3273 |
0.311 |
|
| 2009 |
Sellan M, Rose RA, Cifelli C, Heximer SP, Backx P. Chronic Iron-overload Causes Sinus Bradycardia By Altering Electrical Activity In Sinoatrial Node Myocytes Biophysical Journal. 96: 259a-260a. DOI: 10.1016/J.Bpj.2008.12.1282 |
0.336 |
|
| 2008 |
Backx PH. Sulfonylurea receptor expression heterogeneity suggests chamber-specific roles for sarcolemmal KATP channels in heart. Circulation Research. 103: 1345-7. PMID 19059835 DOI: 10.1161/Circresaha.108.189738 |
0.357 |
|
| 2008 |
So PP, Backx PH, Dorian P. Slow delayed rectifier K+ current block by HMR 1556 increases dispersion of repolarization and promotes Torsades de Pointes in rabbit ventricles. British Journal of Pharmacology. 155: 1185-94. PMID 18836478 DOI: 10.1038/Bjp.2008.354 |
0.357 |
|
| 2008 |
Ban K, Cooper AJ, Samuel S, Bhatti A, Patel M, Izumo S, Penninger JM, Backx PH, Oudit GY, Tsushima RG. Phosphatidylinositol 3-kinase gamma is a critical mediator of myocardial ischemic and adenosine-mediated preconditioning. Circulation Research. 103: 643-53. PMID 18688045 DOI: 10.1161/Circresaha.108.175018 |
0.392 |
|
| 2008 |
Rose RA, Jiang H, Wang X, Helke S, Tsoporis JN, Gong N, Keating SC, Parker TG, Backx PH, Keating A. Bone marrow-derived mesenchymal stromal cells express cardiac-specific markers, retain the stromal phenotype, and do not become functional cardiomyocytes in vitro. Stem Cells (Dayton, Ohio). 26: 2884-92. PMID 18687994 DOI: 10.1634/Stemcells.2008-0329 |
0.346 |
|
| 2008 |
Cifelli C, Rose RA, Zhang H, Voigtlaender-Bolz J, Bolz SS, Backx PH, Heximer SP. RGS4 regulates parasympathetic signaling and heart rate control in the sinoatrial node. Circulation Research. 103: 527-35. PMID 18658048 DOI: 10.1161/Circresaha.108.180984 |
0.398 |
|
| 2008 |
Zhu Y, Gramolini AO, Walsh MA, Zhou YQ, Slorach C, Friedberg MK, Takeuchi JK, Sun H, Henkelman RM, Backx PH, Redington AN, Maclennan DH, Bruneau BG. Tbx5-dependent pathway regulating diastolic function in congenital heart disease. Proceedings of the National Academy of Sciences of the United States of America. 105: 5519-24. PMID 18378906 DOI: 10.1073/Pnas.0801779105 |
0.457 |
|
| 2008 |
Borchert GH, Giggey M, Kolar F, Wong TM, Backx PH, Escriba PV. 2-hydroxyoleic acid affects cardiomyocyte [Ca2+]i transient and contractility in a region-dependent manner. American Journal of Physiology. Heart and Circulatory Physiology. 294: H1948-55. PMID 18296566 DOI: 10.1152/Ajpheart.01209.2007 |
0.377 |
|
| 2008 |
Oudit GY, Kassiri Z, Zhou J, Liu QC, Liu PP, Backx PH, Dawood F, Crackower MA, Scholey JW, Penninger JM. Loss of PTEN attenuates the development of pathological hypertrophy and heart failure in response to biomechanical stress. Cardiovascular Research. 78: 505-14. PMID 18281373 DOI: 10.1093/Cvr/Cvn041 |
0.592 |
|
| 2008 |
Gramolini AO, Kislinger T, Alikhani-Koopaei R, Fong V, Thompson NJ, Isserlin R, Sharma P, Oudit GY, Trivieri MG, Fagan A, Kannan A, Higgins DG, Huedig H, Hess G, Arab S, ... ... Backx PH, et al. Comparative proteomics profiling of a phospholamban mutant mouse model of dilated cardiomyopathy reveals progressive intracellular stress responses. Molecular & Cellular Proteomics : McP. 7: 519-33. PMID 18056057 DOI: 10.1074/Mcp.M700245-Mcp200 |
0.397 |
|
| 2008 |
Kim KH, Oudit GY, Backx PH. Erythropoietin protects against doxorubicin-induced cardiomyopathy via a phosphatidylinositol 3-kinase-dependent pathway. The Journal of Pharmacology and Experimental Therapeutics. 324: 160-9. PMID 17928571 DOI: 10.1124/Jpet.107.125773 |
0.719 |
|
| 2007 |
Rose RA, Kabir MG, Backx PH. Altered heart rate and sinoatrial node function in mice lacking the cAMP regulator phosphoinositide 3-kinase-gamma. Circulation Research. 101: 1274-82. PMID 17975110 DOI: 10.1161/Circresaha.107.158428 |
0.46 |
|
| 2007 |
Kerfant BG, Zhao D, Lorenzen-Schmidt I, Wilson LS, Cai S, Chen SR, Maurice DH, Backx PH. PI3Kgamma is required for PDE4, not PDE3, activity in subcellular microdomains containing the sarcoplasmic reticular calcium ATPase in cardiomyocytes. Circulation Research. 101: 400-8. PMID 17615371 DOI: 10.1161/Circresaha.107.156422 |
0.395 |
|
| 2007 |
Wong DW, Oudit GY, Reich H, Kassiri Z, Zhou J, Liu QC, Backx PH, Penninger JM, Herzenberg AM, Scholey JW. Loss of angiotensin-converting enzyme-2 (Ace2) accelerates diabetic kidney injury. The American Journal of Pathology. 171: 438-51. PMID 17600118 DOI: 10.2353/Ajpath.2007.060977 |
0.554 |
|
| 2007 |
So PP, Backx PH, Hu XD, Dorian P. I(Ks) block by HMR 1556 lowers ventricular defibrillation threshold and reverses the repolarization shortening by isoproterenol without rate-dependence in rabbits. Journal of Cardiovascular Electrophysiology. 18: 750-6. PMID 17578345 DOI: 10.1111/J.1540-8167.2007.00812.X |
0.383 |
|
| 2007 |
Mu J, Qu D, Bartczak A, Phillips MJ, Manuel J, He W, Koscik C, Mendicino M, Zhang L, Clark DA, Grant DR, Backx PH, Levy GA, Adamson SL. Fgl2 deficiency causes neonatal death and cardiac dysfunction during embryonic and postnatal development in mice. Physiological Genomics. 31: 53-62. PMID 17550996 DOI: 10.1152/Physiolgenomics.00026.2007 |
0.375 |
|
| 2007 |
Oudit GY, Kassiri Z, Patel MP, Chappell M, Butany J, Backx PH, Tsushima RG, Scholey JW, Khokha R, Penninger JM. Angiotensin II-mediated oxidative stress and inflammation mediate the age-dependent cardiomyopathy in ACE2 null mice. Cardiovascular Research. 75: 29-39. PMID 17499227 DOI: 10.1016/J.Cardiores.2007.04.007 |
0.608 |
|
| 2007 |
Oudit GY, Korley V, Backx PH, Dorian P. Lithium-induced sinus node disease at therapeutic concentrations: linking lithium-induced blockade of sodium channels to impaired pacemaker activity. The Canadian Journal of Cardiology. 23: 229-32. PMID 17347696 DOI: 10.1016/S0828-282X(07)70750-X |
0.314 |
|
| 2007 |
Martino TA, Tata N, Belsham DD, Chalmers J, Straume M, Lee P, Pribiag H, Khaper N, Liu PP, Dawood F, Backx PH, Ralph MR, Sole MJ. Disturbed diurnal rhythm alters gene expression and exacerbates cardiovascular disease with rescue by resynchronization. Hypertension. 49: 1104-13. PMID 17339537 DOI: 10.1161/Hypertensionaha.106.083568 |
0.358 |
|
| 2007 |
Anini Y, Izzo A, Oudit GY, Backx PH, Brubaker PL. Role of phosphatidylinositol-3 kinase-gamma in the actions of glucagon-like peptide-2 on the murine small intestine. American Journal of Physiology. Endocrinology and Metabolism. 292: E1599-606. PMID 17284578 DOI: 10.1152/Ajpendo.00429.2006 |
0.31 |
|
| 2007 |
Borchert GH, Giggey M, Kolar F, Wong TM, Backx PH, Escriba PV. 2-Hydroxyoleic acid increases Ca2+-transient and contractility in rat ventricular myocytes in a region-dependent manner Journal of Molecular and Cellular Cardiology. 42: S39. DOI: 10.1016/J.Yjmcc.2007.03.109 |
0.318 |
|
| 2006 |
Gong N, Bodi I, Zobel C, Schwartz A, Molkentin JD, Backx PH. Calcineurin increases cardiac transient outward K+ currents via transcriptional up-regulation of Kv4.2 channel subunits. The Journal of Biological Chemistry. 281: 38498-506. PMID 17060317 DOI: 10.1074/Jbc.M607774200 |
0.373 |
|
| 2006 |
Kerfant BG, Rose RA, Sun H, Backx PH. Phosphoinositide 3-kinase gamma regulates cardiac contractility by locally controlling cyclic adenosine monophosphate levels. Trends in Cardiovascular Medicine. 16: 250-6. PMID 16980183 DOI: 10.1016/J.Tcm.2006.04.006 |
0.442 |
|
| 2006 |
Oudit GY, Herzenberg AM, Kassiri Z, Wong D, Reich H, Khokha R, Crackower MA, Backx PH, Penninger JM, Scholey JW. Loss of angiotensin-converting enzyme-2 leads to the late development of angiotensin II-dependent glomerulosclerosis. The American Journal of Pathology. 168: 1808-20. PMID 16723697 DOI: 10.2353/Ajpath.2006.051091 |
0.565 |
|
| 2006 |
Sun H, Kerfant BG, Zhao D, Trivieri MG, Oudit GY, Penninger JM, Backx PH. Insulin-like growth factor-1 and PTEN deletion enhance cardiac L-type Ca2+ currents via increased PI3Kalpha/PKB signaling. Circulation Research. 98: 1390-7. PMID 16627784 DOI: 10.1161/01.Res.0000223321.34482.8C |
0.406 |
|
| 2006 |
Trivieri MG, Oudit GY, Sah R, Kerfant BG, Sun H, Gramolini AO, Pan Y, Wickenden AD, Croteau W, Morreale de Escobar G, Pekhletski R, St Germain D, Maclennan DH, Backx PH. Cardiac-specific elevations in thyroid hormone enhance contractility and prevent pressure overload-induced cardiac dysfunction. Proceedings of the National Academy of Sciences of the United States of America. 103: 6043-8. PMID 16595628 DOI: 10.1073/Pnas.0601072103 |
0.729 |
|
| 2006 |
So PP, Hu XD, Backx PH, Puglisi JL, Dorian P. Blockade of IKs by HMR 1556 increases the reverse rate-dependence of refractoriness prolongation by dofetilide in isolated rabbit ventricles. British Journal of Pharmacology. 148: 255-63. PMID 16565733 DOI: 10.1038/Sj.Bjp.0706721 |
0.329 |
|
| 2006 |
Xu J, Gong NL, Bodi I, Aronow BJ, Backx PH, Molkentin JD. Myocyte enhancer factors 2A and 2C induce dilated cardiomyopathy in transgenic mice. The Journal of Biological Chemistry. 281: 9152-62. PMID 16469744 DOI: 10.1074/Jbc.M510217200 |
0.42 |
|
| 2006 |
Gramolini AO, Trivieri MG, Oudit GY, Kislinger T, Li W, Patel MM, Emili A, Kranias EG, Backx PH, Maclennan DH. Cardiac-specific overexpression of sarcolipin in phospholamban null mice impairs myocyte function that is restored by phosphorylation. Proceedings of the National Academy of Sciences of the United States of America. 103: 2446-51. PMID 16461894 DOI: 10.1073/Pnas.0510883103 |
0.425 |
|
| 2006 |
Oudit G, Herzenberg A, Kassiri Z, Wong D, Reich H, Khokha R, Crackower M, Backx P, Penninger J, Scholey J. Angiotensin-Converting Enzyme-2 (ACE2)—A New Player in the Genesis of Glomerular Injury? Journal of the American Society of Nephrology. 17: 2637-2643. DOI: 10.1681/Asn.2006080888 |
0.463 |
|
| 2005 |
Joza N, Oudit GY, Brown D, Bénit P, Kassiri Z, Vahsen N, Benoit L, Patel MM, Nowikovsky K, Vassault A, Backx PH, Wada T, Kroemer G, Rustin P, Penninger JM. Muscle-specific loss of apoptosis-inducing factor leads to mitochondrial dysfunction, skeletal muscle atrophy, and dilated cardiomyopathy. Molecular and Cellular Biology. 25: 10261-72. PMID 16287843 DOI: 10.1128/Mcb.25.23.10261-10272.2005 |
0.58 |
|
| 2005 |
Hui K, Gardzinski P, Sun HS, Backx PH, Feng ZP. Permeable ions differentially affect gating kinetics and unitary conductance of L-type calcium channels. Biochemical and Biophysical Research Communications. 338: 783-92. PMID 16243294 DOI: 10.1016/J.Bbrc.2005.10.014 |
0.343 |
|
| 2005 |
Costantini DL, Arruda EP, Agarwal P, Kim KH, Zhu Y, Zhu W, Lebel M, Cheng CW, Park CY, Pierce SA, Guerchicoff A, Pollevick GD, Chan TY, Kabir MG, Cheng SH, ... ... Backx PH, et al. The homeodomain transcription factor Irx5 establishes the mouse cardiac ventricular repolarization gradient. Cell. 123: 347-58. PMID 16239150 DOI: 10.1016/J.Cell.2005.08.004 |
0.76 |
|
| 2005 |
Kassiri Z, Oudit GY, Sanchez O, Dawood F, Mohammed FF, Nuttall RK, Edwards DR, Liu PP, Backx PH, Khokha R. Combination of tumor necrosis factor-alpha ablation and matrix metalloproteinase inhibition prevents heart failure after pressure overload in tissue inhibitor of metalloproteinase-3 knock-out mice. Circulation Research. 97: 380-90. PMID 16037568 DOI: 10.1161/01.Res.0000178789.16929.Cf |
0.588 |
|
| 2005 |
Kerfant BG, Gidrewicz D, Sun H, Oudit GY, Penninger JM, Backx PH. Cardiac sarcoplasmic reticulum calcium release and load are enhanced by subcellular cAMP elevations in PI3Kgamma-deficient mice. Circulation Research. 96: 1079-86. PMID 15860757 DOI: 10.1161/01.Res.0000168066.06333.Df |
0.402 |
|
| 2005 |
D'Avanzo N, Cho HC, Tolokh I, Pekhletski R, Tolokh I, Gray C, Goldman S, Backx PH. Conduction through the inward rectifier potassium channel, Kir2.1, is increased by negatively charged extracellular residues. The Journal of General Physiology. 125: 493-503. PMID 15824191 DOI: 10.1085/Jgp.200409175 |
0.694 |
|
| 2005 |
Tolokh IS, Tolokh II, Cho HC, D'Avanzo N, Backx PH, Goldman S, Gray CG. Non-Michaelis-Menten kinetics model for conductance of low-conductance potassium ion channels. Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics. 71: 021912. PMID 15783357 DOI: 10.1103/Physreve.71.021912 |
0.667 |
|
| 2005 |
Tsang SY, Tsushima RG, Tomaselli GF, Li RA, Backx PH. A multifunctional aromatic residue in the external pore vestibule of Na+ channels contributes to the local anesthetic receptor. Molecular Pharmacology. 67: 424-34. PMID 15659774 DOI: 10.1124/Mol.67.2 |
0.337 |
|
| 2005 |
Ricci R, Eriksson U, Oudit GY, Eferl R, Akhmedov A, Sumara I, Sumara G, Kassiri Z, David JP, Bakiri L, Sasse B, Idarraga MH, Rath M, Kurz D, Theussl HC, ... ... Backx P, et al. Distinct functions of junD in cardiac hypertrophy and heart failure. Genes & Development. 19: 208-13. PMID 15655111 DOI: 10.1101/Gad.327005 |
0.636 |
|
| 2005 |
Zhu W, Ye L, Wu J, Backx PH, Tsui L, Hu J, Gross GJ. Catechol-dependent cardiac arrhythmias associated with chloride channel overexpression in murine heart Heart Rhythm. 2: S294. DOI: 10.1016/J.Hrthm.2005.02.925 |
0.424 |
|
| 2004 |
Oudit GY, Sun H, Kerfant BG, Crackower MA, Penninger JM, Backx PH. The role of phosphoinositide-3 kinase and PTEN in cardiovascular physiology and disease. Journal of Molecular and Cellular Cardiology. 37: 449-71. PMID 15276015 DOI: 10.1016/J.Yjmcc.2004.05.015 |
0.33 |
|
| 2004 |
Diaz RJ, Zobel C, Cho HC, Batthish M, Hinek A, Backx PH, Wilson GJ. Selective inhibition of inward rectifier K+ channels (Kir2.1 or Kir2.2) abolishes protection by ischemic preconditioning in rabbit ventricular cardiomyocytes. Circulation Research. 95: 325-32. PMID 15231687 DOI: 10.1161/01.Res.0000137727.34938.35 |
0.39 |
|
| 2004 |
Asahi M, Otsu K, Nakayama H, Hikoso S, Takeda T, Gramolini AO, Trivieri MG, Oudit GY, Morita T, Kusakari Y, Hirano S, Hongo K, Hirotani S, Yamaguchi O, Peterson A, ... Backx PH, et al. Cardiac-specific overexpression of sarcolipin inhibits sarco(endo)plasmic reticulum Ca2+ ATPase (SERCA2a) activity and impairs cardiac function in mice. Proceedings of the National Academy of Sciences of the United States of America. 101: 9199-204. PMID 15201433 DOI: 10.1073/Pnas.0402596101 |
0.468 |
|
| 2004 |
Sun H, Oudit GY, Ramirez RJ, Costantini D, Backx PH. The phosphoinositide 3-kinase inhibitor LY294002 enhances cardiac myocyte contractility via a direct inhibition of Ik,slow currents. Cardiovascular Research. 62: 509-20. PMID 15158143 DOI: 10.1016/J.Cardiores.2004.01.029 |
0.623 |
|
| 2004 |
Martino T, Tata N, Arab S, Ralph M, Belsham D, Straume M, Lee P, Backx P, Dawood F, Wen W, Liu P, Sole M. Circadian gene expression is essential for remodelling in heart disease Journal of Cardiac Failure. 10: S39. DOI: 10.1016/J.Cardfail.2004.06.076 |
0.332 |
|
| 2003 |
Jiang J, Jiang J, Backx PH, Teoh H, Ward ME. Role of Cl- currents in rat aortic smooth muscle activation by prostaglandin F2 alpha. European Journal of Pharmacology. 481: 133-40. PMID 14642777 DOI: 10.1016/J.Ejphar.2003.09.015 |
0.308 |
|
| 2003 |
Oudit GY, Crackower MA, Eriksson U, Sarao R, Kozieradzki I, Sasaki T, Irie-Sasaki J, Gidrewicz D, Rybin VO, Wada T, Steinberg SF, Backx PH, Penninger JM. Phosphoinositide 3-kinase gamma-deficient mice are protected from isoproterenol-induced heart failure. Circulation. 108: 2147-52. PMID 12963636 DOI: 10.1161/01.Cir.0000091403.62293.2B |
0.39 |
|
| 2003 |
Oudit GY, Sun H, Trivieri MG, Koch SE, Dawood F, Ackerley C, Yazdanpanah M, Wilson GJ, Schwartz A, Liu PP, Backx PH. L-type Ca2+ channels provide a major pathway for iron entry into cardiomyocytes in iron-overload cardiomyopathy. Nature Medicine. 9: 1187-94. PMID 12937413 DOI: 10.1038/Nm920 |
0.313 |
|
| 2003 |
Zobel C, Cho HC, Nguyen TT, Pekhletski R, Diaz RJ, Wilson GJ, Backx PH. Molecular dissection of the inward rectifier potassium current (IK1) in rabbit cardiomyocytes: evidence for heteromeric co-assembly of Kir2.1 and Kir2.2. The Journal of Physiology. 550: 365-72. PMID 12794173 DOI: 10.1113/Jphysiol.2002.036400 |
0.395 |
|
| 2003 |
Oudit GY, Crackower MA, Backx PH, Penninger JM. The role of ACE2 in cardiovascular physiology. Trends in Cardiovascular Medicine. 13: 93-101. PMID 12691672 DOI: 10.1016/S1050-1738(02)00233-5 |
0.329 |
|
| 2003 |
Diaz RJ, Armstrong SC, Batthish M, Backx PH, Ganote CE, Wilson GJ. Enhanced cell volume regulation: a key protective mechanism of ischemic preconditioning in rabbit ventricular myocytes. Journal of Molecular and Cellular Cardiology. 35: 45-58. PMID 12623299 DOI: 10.1016/S0022-2828(02)00277-8 |
0.325 |
|
| 2003 |
Sah R, Ramirez RJ, Oudit GY, Gidrewicz D, Trivieri MG, Zobel C, Backx PH. Regulation of cardiac excitation-contraction coupling by action potential repolarization: role of the transient outward potassium current (I(to)). The Journal of Physiology. 546: 5-18. PMID 12509475 DOI: 10.1113/Jphysiol.2002.026468 |
0.789 |
|
| 2002 |
Zobel C, Kassiri Z, Nguyen TT, Meng Y, Backx PH. Prevention of hypertrophy by overexpression of Kv4.2 in cultured neonatal cardiomyocytes. Circulation. 106: 2385-91. PMID 12403671 DOI: 10.1161/01.Cir.0000033970.22130.93 |
0.642 |
|
| 2002 |
Crackower MA, Oudit GY, Kozieradzki I, Sarao R, Sun H, Sasaki T, Hirsch E, Suzuki A, Shioi T, Irie-Sasaki J, Sah R, Cheng HY, Rybin VO, Lembo G, Fratta L, ... ... Backx PH, et al. Regulation of myocardial contractility and cell size by distinct PI3K-PTEN signaling pathways. Cell. 110: 737-49. PMID 12297047 DOI: 10.1016/S0092-8674(02)00969-8 |
0.702 |
|
| 2002 |
Kaprielian R, Sah R, Nguyen T, Wickenden AD, Backx PH. Myocardial infarction in rat eliminates regional heterogeneity of AP profiles, I(to) K(+) currents, and [Ca(2+)](i) transients. American Journal of Physiology. Heart and Circulatory Physiology. 283: H1157-68. PMID 12181147 DOI: 10.1152/Ajpheart.00518.2001 |
0.805 |
|
| 2002 |
Batthish M, Diaz RJ, Zeng HP, Backx PH, Wilson GJ. Pharmacological preconditioning in rabbit myocardium is blocked by chloride channel inhibition. Cardiovascular Research. 55: 660-71. PMID 12160963 DOI: 10.1016/S0008-6363(02)00454-6 |
0.31 |
|
| 2002 |
Crackower MA, Sarao R, Oudit GY, Yagil C, Kozieradzki I, Scanga SE, Oliveira-dos-Santos AJ, da Costa J, Zhang L, Pei Y, Scholey J, Ferrario CM, Manoukian AS, Chappell MC, Backx PH, et al. Angiotensin-converting enzyme 2 is an essential regulator of heart function. Nature. 417: 822-8. PMID 12075344 DOI: 10.1038/Nature00786 |
0.386 |
|
| 2002 |
Kassiri Z, Hajjar R, Backx PH. Molecular components of transient outward potassium current in cultured neonatal rat ventricular myocytes. Journal of Molecular Medicine (Berlin, Germany). 80: 351-8. PMID 12072910 DOI: 10.1007/S00109-002-0325-7 |
0.581 |
|
| 2002 |
Sah R, Oudit GY, Nguyen TT, Lim HW, Wickenden AD, Wilson GJ, Molkentin JD, Backx PH. Inhibition of calcineurin and sarcolemmal Ca2+ influx protects cardiac morphology and ventricular function in K(v)4.2N transgenic mice. Circulation. 105: 1850-6. PMID 11956130 DOI: 10.1161/01.Cir.0000014211.47830.4D |
0.72 |
|
| 2002 |
Kassiri Z, Zobel C, Nguyen TT, Molkentin JD, Backx PH. Reduction of I(to) causes hypertrophy in neonatal rat ventricular myocytes. Circulation Research. 90: 578-85. PMID 11909822 DOI: 10.1161/01.Res.0000012223.86441.A1 |
0.609 |
|
| 2002 |
Sah R, Ramirez RJ, Backx PH. Modulation of Ca(2+) release in cardiac myocytes by changes in repolarization rate: role of phase-1 action potential repolarization in excitation-contraction coupling. Circulation Research. 90: 165-73. PMID 11834709 DOI: 10.1161/Hh0202.103315 |
0.758 |
|
| 2002 |
Yazdanpanah M, Oudit G, Lee A, Dawood F, Wen W, Backx P, Liu P. Cytotoxic aldehydes aggravate ventricular dysfunction in an injured heart: evidence from an iron overload model of heart failure Journal of the American College of Cardiology. 39: 175. DOI: 10.1016/S0735-1097(02)80775-6 |
0.334 |
|
| 2001 |
Diaz RJ, Batthish M, Backx PH, Wilson GJ. Chloride channel inhibition does block the protection of ischemic preconditioning in myocardium. Journal of Molecular and Cellular Cardiology. 33: 1887-9; author reply. PMID 11603930 DOI: 10.1006/Jmcc.2001.1451 |
0.302 |
|
| 2001 |
Nishiyama A, Ishii DN, Backx PH, Pulford BE, Birks BR, Tamkun MM. Altered K(+) channel gene expression in diabetic rat ventricle: isoform switching between Kv4.2 and Kv1.4. American Journal of Physiology. Heart and Circulatory Physiology. 281: H1800-7. PMID 11557574 DOI: 10.1152/Ajpheart.2001.281.4.H1800 |
0.325 |
|
| 2001 |
Macdonald PE, Ha XF, Wang J, Smukler SR, Sun AM, Gaisano HY, Salapatek AMF, Backx PH, Wheeler MB. Members of the Kv1 and Kv2 voltage-dependent K+ channel families regulate insulin secretion Molecular Endocrinology. 15: 1423-1435. PMID 11463864 DOI: 10.1210/Mend.15.8.0685 |
0.329 |
|
| 2001 |
Sah R, Ramirez RJ, Kaprielian R, Backx PH. Alterations in action potential profile enhance excitation-contraction coupling in rat cardiac myocytes. The Journal of Physiology. 533: 201-14. PMID 11351028 DOI: 10.1111/J.1469-7793.2001.0201B.X |
0.793 |
|
| 2001 |
Oudit GY, Kassiri Z, Sah R, Ramirez RJ, Zobel C, Backx PH. The molecular physiology of the cardiac transient outward potassium current (I(to)) in normal and diseased myocardium. Journal of Molecular and Cellular Cardiology. 33: 851-72. PMID 11343410 DOI: 10.1006/Jmcc.2001.1376 |
0.787 |
|
| 2000 |
Zvaritch E, Backx PH, Jirik F, Kimura Y, de Leon S, Schmidt AG, Hoit BD, Lester JW, Kranias EG, MacLennan DH. The transgenic expression of highly inhibitory monomeric forms of phospholamban in mouse heart impairs cardiac contractility. The Journal of Biological Chemistry. 275: 14985-91. PMID 10809743 DOI: 10.1074/Jbc.275.20.14985 |
0.425 |
|
| 2000 |
Wickenden AD, Kaprielian R, You XM, Backx PH. The thyroid hormone analog DITPA restores I(to) in rats after myocardial infarction. American Journal of Physiology. Heart and Circulatory Physiology. 278: H1105-16. PMID 10749704 DOI: 10.1152/Ajpheart.2000.278.4.H1105 |
0.788 |
|
| 2000 |
Kassiri Z, Myers R, Kaprielian R, Banijamali HS, Backx PH. Rate-dependent changes of twitch force duration in rat cardiac trabeculae: a property of the contractile system. The Journal of Physiology. 524: 221-31. PMID 10747194 DOI: 10.1111/J.1469-7793.2000.T01-3-00221.X |
0.785 |
|
| 1999 |
Bartfay WJ, Dawood F, Wen WH, Lehotay DC, Hou D, Bartfay E, Luo X, Backx PH, Liu PP. Cardiac function and cytotoxic aldehyde production in a murine model of chronic iron-overload. Cardiovascular Research. 43: 892-900. PMID 10615416 DOI: 10.1016/S0008-6363(99)00040-1 |
0.314 |
|
| 1999 |
Wickenden AD, Lee P, Sah R, Huang Q, Fishman GI, Backx PH. Targeted expression of a dominant-negative K(v)4.2 K(+) channel subunit in the mouse heart. Circulation Research. 85: 1067-76. PMID 10571538 DOI: 10.1161/01.Res.85.11.1067 |
0.71 |
|
| 1999 |
Li RA, Tsushima RG, Himmeldirk K, Dime DS, Backx PH. Local anesthetic anchoring to cardiac sodium channels. Implications into tissue-selective drug targeting. Circulation Research. 85: 88-98. PMID 10400914 DOI: 10.1161/01.Res.85.1.88 |
0.376 |
|
| 1999 |
Tsushima RG, Wickenden AD, Bouchard RA, Oudit GY, Liu PP, Backx PH. Modulation of iron uptake in heart by L-type Ca2+ channel modifiers: possible implications in iron overload. Circulation Research. 84: 1302-9. PMID 10364568 DOI: 10.1161/01.Res.84.11.1302 |
0.322 |
|
| 1999 |
Wickenden AD, Tsushima RG, Losito VA, Kaprielian R, Backx PH. Effect of Cd2+ on Kv4.2 and Kv1.4 expressed in Xenopus oocytes and on the transient outward currents in rat and rabbit ventricular myocytes. Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology. 9: 11-28. PMID 10352341 DOI: 10.1159/000016299 |
0.764 |
|
| 1999 |
Wickenden AD, Jegla TJ, Kaprielian R, Backx PH. Regional contributions of Kv1.4, Kv4.2, and Kv4.3 to transient outward K+ current in rat ventricle. The American Journal of Physiology. 276: H1599-607. PMID 10330244 DOI: 10.1152/Ajpheart.1999.276.5.H1599 |
0.768 |
|
| 1999 |
Kaprielian R, Wickenden AD, Kassiri Z, Parker TG, Liu PP, Backx PH. Relationship between K+ channel down-regulation and [Ca2+]i in rat ventricular myocytes following myocardial infarction. The Journal of Physiology. 517: 229-45. PMID 10226162 DOI: 10.1111/J.1469-7793.1999.0229Z.X |
0.819 |
|
| 1999 |
Diaz RJ, Losito VA, Mao GD, Ford MK, Backx PH, Wilson GJ. Chloride channel inhibition blocks the protection of ischemic preconditioning and hypo-osmotic stress in rabbit ventricular myocardium. Circulation Research. 84: 763-75. PMID 10205144 DOI: 10.1161/01.Res.84.7.763 |
0.333 |
|
| 1999 |
Tsushima RG, Borges A, Backx PH. Inactivated state dependence of sodium channel modulation by beta-scorpion toxin. Pflugers Archiv : European Journal of Physiology. 437: 661-8. PMID 10087142 DOI: 10.1007/S004240050830 |
0.324 |
|
| 1998 |
Sah RL, Tsushima RG, Backx PH. Effects of local anesthetics on Nachannels containing the equine hyperkalemic periodic paralysis mutation. American Journal of Physiology. Cell Physiology. 275: C389-C400. PMID 29585668 DOI: 10.1152/ajpcell.1998.275.2.C389 |
0.631 |
|
| 1998 |
Sah RL, Tsushima RG, Backx PH. Effects of local anesthetics on Na+ channels containing the equine hyperkalemic periodic paralysis mutation. The American Journal of Physiology. 275: C389-400. PMID 9688593 DOI: 10.1152/Ajpcell.1998.275.2.C389 |
0.667 |
|
| 1998 |
Wickenden AD, Kaprielian R, Kassiri Z, Tsoporis JN, Tsushima R, Fishman GI, Backx PH. The role of action potential prolongation and altered intracellular calcium handling in the pathogenesis of heart failure. Cardiovascular Research. 37: 312-23. PMID 9614488 DOI: 10.1016/S0008-6363(97)00256-3 |
0.801 |
|
| 1997 |
Wickenden AD, Kaprielian R, Parker TG, Jones OT, Backx PH. Effects of development and thyroid hormone on K+ currents and K+ channel gene expression in rat ventricle. The Journal of Physiology. 504: 271-86. PMID 9365903 DOI: 10.1111/J.1469-7793.1997.271Be.X |
0.781 |
|
| 1997 |
Tsushima RG, Li RA, Backx PH. Altered ionic selectivity of the sodium channel revealed by cysteine mutations within the pore. The Journal of General Physiology. 109: 463-75. PMID 9101405 DOI: 10.1085/Jgp.109.4.463 |
0.329 |
|
| 1996 |
Hanna WJ, Tsushima RG, Sah R, McCutcheon LJ, Marban E, Backx PH. The equine periodic paralysis Na+ channel mutation alters molecular transitions between the open and inactivated states. The Journal of Physiology. 497: 349-64. PMID 8961180 |
0.651 |
|
| 1995 |
Atar D, Backx PH, Appel MM, Gao WD, Marban E. Excitation-transcription coupling mediated by zinc influx through voltage-dependent calcium channels. The Journal of Biological Chemistry. 270: 2473-7. PMID 7852308 DOI: 10.1074/Jbc.270.6.2473 |
0.409 |
|
| 1995 |
Gao WD, Atar D, Backx PH, Marban E. Relationship between intracellular calcium and contractile force in stunned myocardium. Direct evidence for decreased myofilament Ca2+ responsiveness and altered diastolic function in intact ventricular muscle. Circulation Research. 76: 1036-48. PMID 7758158 DOI: 10.1161/01.Res.76.6.1036 |
0.408 |
|
| 1995 |
Backx PH, Gao WD, Azan-Backx MD, Marban E. The relationship between contractile force and intracellular [Ca2+] in intact rat cardiac trabeculae. The Journal of General Physiology. 105: 1-19. PMID 7730787 DOI: 10.1085/Jgp.105.1.1 |
0.345 |
|
| 1995 |
Dobrunz LE, Backx PH, Yue DT. Steady-state [Ca2+]i-force relationship in intact twitching cardiac muscle: direct evidence for modulation by isoproterenol and EMD 53998. Biophysical Journal. 69: 189-201. PMID 7669896 DOI: 10.1016/S0006-3495(95)79889-7 |
0.356 |
|
| 1995 |
Tomaselli GF, Chiamvimonvat N, Nuss HB, Balser JR, Perez-Garcia MT, Ruo Hui Xu, Orias DW, Backx PH, Marban E. A mutation in the pore of the sodium channel alters gating Biophysical Journal. 68: 1814-1827. PMID 7612823 DOI: 10.1016/S0006-3495(95)80358-9 |
0.329 |
|
| 1994 |
Backx PH, Gao WD, Azan-Backx MD, Marban E. Regulation of intracellular calcium in cardiac muscle. Advances in Experimental Medicine and Biology. 346: 3-10. PMID 8184768 DOI: 10.1007/978-1-4615-2946-0_1 |
0.393 |
|
| 1994 |
Gao WD, Backx PH, Azan-Backx M, Marban E. Myofilament Ca2+ sensitivity in intact versus skinned rat ventricular muscle. Circulation Research. 74: 408-15. PMID 8118949 DOI: 10.1161/01.Res.74.3.408 |
0.35 |
|
| 1994 |
Backx PH, Gao WD, Azan-Backx MD, Marban E. Mechanism of force inhibition by 2,3-butanedione monoxime in rat cardiac muscle: roles of [Ca2+]i and cross-bridge kinetics. The Journal of Physiology. 476: 487-500. PMID 8057256 DOI: 10.1113/Jphysiol.1994.Sp020149 |
0.342 |
|
| 1993 |
Backx PH, Ter Keurs HE. Fluorescent properties of rat cardiac trabeculae microinjected with fura-2 salt. The American Journal of Physiology. 264: H1098-110. PMID 8476086 DOI: 10.1152/ajpheart.1993.264.4.H1098 |
0.613 |
|
| 1993 |
Backx PH, Marban E. Background potassium current active during the plateau of the action potential in guinea pig ventricular myocytes. Circulation Research. 72: 890-900. PMID 8443875 DOI: 10.1161/01.Res.72.4.890 |
0.383 |
|
| 1993 |
Kusuoka H, Backx PH, Camilion de Hurtado M, Azan-Backx M, Marban E, Cingolani HE. Relative roles of intracellular Ca2+ and pH in shaping myocardial contractile response to acute respiratory alkalosis. The American Journal of Physiology. 265: H1696-703. PMID 8238582 DOI: 10.1152/Ajpheart.1993.265.5.H1696 |
0.381 |
|
| 1992 |
ter Keurs HE, Backx PH, Banijamali H, MacIntosh B, Gao WD. Calcium release and force development in rat myocardium. Advances in Experimental Medicine and Biology. 311: 199-212. PMID 1529754 DOI: 10.1007/978-1-4615-3362-7_14 |
0.613 |
|
| 1992 |
Backx PH, Yue DT, Lawrence JH, Marban E, Tomaselli GF. Molecular localization of an ion-binding site within the pore of mammalian sodium channels. Science (New York, N.Y.). 257: 248-51. PMID 1321496 DOI: 10.1126/Science.1321496 |
0.34 |
|
| 1992 |
O'Rourke B, Backx PH, Marban E. Phosphorylation-independent modulation of L-type calcium channels by magnesium-nucleotide complexes. Science (New York, N.Y.). 257: 245-8. PMID 1321495 DOI: 10.1126/Science.1321495 |
0.34 |
|
| 1991 |
Stone JA, Backx PH, ter Keurs HE. The effect of atrial natriuretic factor on force development in rat cardiac trabeculae. Canadian Journal of Physiology and Pharmacology. 68: 1247-54. PMID 2148905 DOI: 10.1139/y90-187 |
0.615 |
|
| 1991 |
Backx PH, O'Rourke B, Marban E. Flash photolysis of magnesium-DM-nitrophen in heart cells. A novel approach to probe magnesium- and ATP-dependent regulation of calcium channels. American Journal of Hypertension. 4: 416S-421S. PMID 1654936 DOI: 10.1093/Ajh/4.7.416S |
0.357 |
|
| 1990 |
Yue DT, Backx PH, Imredy JP. Calcium-sensitive inactivation in the gating of single calcium channels. Science (New York, N.Y.). 250: 1735-8. PMID 2176745 DOI: 10.1126/Science.2176745 |
0.316 |
|
| 1989 |
Backx PH, De Tombe PP, Van Deen JHK, Mulder BJM, Ter Keurs HEDJ. A model of propagating calcium-induced calcium release mediated by calcium diffusion Journal of General Physiology. 93: 963-977. PMID 2738577 |
0.485 |
|
| 1988 |
Ter Keurs HEDJ, Backx PH, De Tombe PP, Mulder BJ. Aftercontractions and excitation-contraction coupling in rat cardiac muscle Canadian Journal of Physiology and Pharmacology. 66: 1239-1245. PMID 3219666 DOI: 10.1139/Y88-204 |
0.593 |
|
| Show low-probability matches. |