Connie J. Eaves - Publications

Affiliations: 
University of British Columbia, Vancouver, Vancouver, BC, Canada 
Area:
Cell Biology
Website:
https://www.bme.ubc.ca/person/connie-eaves/

466 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 He Z, Ghorayeb R, Tan S, Chen K, Lorentzian AC, Bottyan J, Aalam SMM, Pujana MA, Lange PF, Kannan N, Eaves CJ, Maxwell CA. Pathogenic BRCA1 variants disrupt PLK1-regulation of mitotic spindle orientation. Nature Communications. 13: 2200. PMID 35459234 DOI: 10.1038/s41467-022-29885-2  0.339
2021 Lefort S, El-Naggar A, Tan S, Colborne S, Negri GL, Pellacani D, Hirst M, Gusterson B, Morin GB, Sorensen PH, Eaves CJ. De novo and cell line models of human mammary cell transformation reveal an essential role for Yb-1 in multiple stages of human breast cancer. Cell Death and Differentiation. PMID 34294889 DOI: 10.1038/s41418-021-00836-6  0.302
2020 Bulaeva E, Pellacani D, Nakamichi N, Hammond CA, Beer PA, Lorzadeh A, Moksa M, Carles A, Bilenky M, Lefort S, Shu J, Wilhelm BT, Weng AP, Hirst M, Eaves CJ. MYC-induced human acute myeloid leukemia requires a continuing IL-3/GM-CSF costimulus. Blood. 136: 2764-2773. PMID 33301029 DOI: 10.1182/blood.2020006374  0.44
2020 Lefort S, Balani S, Pellacani D, Guyot B, Gorski SM, Maguer-Satta V, Eaves CJ. Single-cell analysis of autophagy activity in normal and de novo transformed human mammary cells. Scientific Reports. 10: 20266. PMID 33219251 DOI: 10.1038/s41598-020-77347-w  0.429
2020 Bulaeva E, Pellacani D, Nakamichi N, Hammond CA, Beer P, Lorzadeh A, Moksa M, Carles A, Bilenky M, Lefort S, Shu JY, Wilhelm B, Weng A, Hirst M, Eaves CJ. MYC-induced human acute myeloid leukemia requires a continuing IL3/GM-CSF co-stimulus. Blood. PMID 32599616 DOI: 10.1182/Blood.2020006374  0.509
2020 Rothe K, Babaian A, Nakamichi N, Chen M, Chafe SC, Watanabe A, Forrest DL, Mager DL, Eaves CJ, Dedhar S, Jiang X. Integrin-Linked Kinase Mediates Therapeutic Resistance of Quiescent CML Stem Cells to Tyrosine Kinase Inhibitors. Cell Stem Cell. PMID 32413332 DOI: 10.1016/J.Stem.2020.04.005  0.473
2020 Grants JM, Wegrzyn-Woltosz J, Hui T, O'Neill K, Shadbolt M, Knapp DJHF, Parker JD, Deng D, Gopal A, Docking TR, Fuller M, Li J, Boldin M, Eaves CJ, Hirst M, et al. Altered microRNA expression links IL6 and TNF-induced inflammaging with myeloid malignancy. Blood. PMID 32384151 DOI: 10.1182/Blood.2019003105  0.321
2020 Lin H, Rothe K, Chen M, Wu A, Babaian A, Yen R, Zeng J, Ruschmann J, Petriv OI, O'Neill K, Maetzig T, Knapp DJHF, Nakamichi N, Brinkman R, Birol I, ... ... Eaves CJ, et al. The miR-185/PAK6 Axis Predicts Therapy Response and Regulates Survival of Drug-Resistant Leukemic Stem Cells in CML. Blood. PMID 32270193 DOI: 10.1182/Blood.2019003636  0.371
2020 Eaves CJ, Pera MF. Cancer Stem Cells: Notes for Authors. Stem Cell Reports. 14: 167-168. PMID 32049060 DOI: 10.1016/J.Stemcr.2020.01.011  0.483
2020 Wang K, Yan Z, Zhang S, Bartholdy B, Eaves CJ, Bouhassira EE. Clonal Origin in Normal Adults of All Blood Lineages and Circulating Hematopoietic Stem Cells. Experimental Hematology. PMID 32007476 DOI: 10.1016/J.Exphem.2020.01.005  0.565
2019 Lefort S, Tan S, Balani S, Rafn B, Pellacani D, Hirst M, Sorensen PH, Eaves CJ. Initiation of human mammary cell tumorigenesis by mutant KRAS requires YAP inactivation. Oncogene. PMID 31772328 DOI: 10.1038/S41388-019-1111-0  0.492
2019 Rivera-Mulia JC, Sasaki T, Trevilla-Garcia C, Nakamichi N, Knapp DJHF, Hammond CA, Chang BH, Tyner JW, Devidas M, Zimmerman J, Klein KN, Somasundaram V, Druker BJ, Gruber TA, Koren A, ... Eaves CJ, et al. Replication timing alterations in leukemia affect clinically relevant chromosome domains. Blood Advances. 3: 3201-3213. PMID 31698451 DOI: 10.1182/Bloodadvances.2019000641  0.471
2019 von Palffy S, Landberg N, Sandén C, Zacharaki D, Shah M, Nakamichi N, Hansen N, Askmyr M, Lilljebjörn H, Rissler M, Karlsson C, Scheding S, Richter J, Eaves CJ, Bhatia R, et al. A high-content cytokine screen identifies myostatin propeptide as a positive regulator of primitive chronic myeloid leukemia cells. Haematologica. PMID 31582541 DOI: 10.3324/Haematol.2019.220434  0.528
2019 Lai D, Chen M, Su J, Liu X, Rothe K, Hu K, Forrest DL, Eaves CJ, Morin GB, Jiang X. Response to Comment on "PP2A inhibition sensitizes cancer stem cells to ABL tyrosine kinase inhibitors in BCR-ABL human leukemia". Science Translational Medicine. 11. PMID 31316004 DOI: 10.1126/Scitranslmed.Aav0819  0.498
2019 Pellacani D, Tan S, Lefort S, Eaves CJ. Transcriptional regulation of normal human mammary cell heterogeneity and its perturbation in breast cancer. The Embo Journal. 38: e100330. PMID 31304632 DOI: 10.15252/Embj.2018100330  0.376
2019 Kusakabe M, Sun AC, Tyshchenko K, Wong R, Nanda A, Shanna C, Gusscott S, Chavez EA, Lorzadeh A, Zhu A, Hill A, Hung S, Brown S, Babaian A, Wang X, ... ... Eaves CJ, et al. Synthetic modeling reveals HOXB genes are critical for the initiation and maintenance of human leukemia. Nature Communications. 10: 2913. PMID 31266935 DOI: 10.1038/S41467-019-10510-8  0.451
2019 Knapp DJHF, Hammond CA, Wang F, Aghaeepour N, Miller PH, Beer PA, Pellacani D, VanInsberghe M, Hansen C, Bendall SC, Nolan GP, Eaves CJ. A topological view of human CD34+ cell state trajectories from integrated single-cell output and proteomic data. Blood. PMID 30622121 DOI: 10.1182/Blood-2018-10-878025  0.545
2019 Sloma I, Beer P, Desterke C, Bulaeva E, Bilenky M, Moksa M, Raghuram K, Brimacombe C, Lambie K, Turhan AG, Wagner-Ballon O, Gaulard P, Humphries RK, Hirst M, Eaves CJ. NUP98-HOXA9-Initiates Molecular and Biologic Features of Disease Progression in a Humanized Model of CML Blood. 134: 4139-4139. DOI: 10.1182/Blood-2019-127839  0.521
2019 Bulaeva E, Pellacani D, Nakamichi N, Beer P, Hammond C, Lorzadeh A, Moksa M, Carles A, Bilenky M, Lefort S, Shu J, Wilhelm BT, Weng AP, Hirst M, Eaves CJ. Growth Factor-Dependent Activation of a MYC-Induced Latent AML Program in Human Hematopoietic Cells Blood. 134: 2533-2533. DOI: 10.1182/Blood-2019-122768  0.526
2019 Sun AC, Kusakabe M, Tyshchenko K, Wei K, Kyroglou E, Huynh T, Gutierrez G, Nanda A, Gusscott S, Humphries K, Hirst M, Eaves C, Weng A. 3169 – ONCOGENE CONTRIBUTIONS IN A SYNTHETIC MODEL OF DE NOVO GENERATED HUMAN T-CELL ACUTE LYMPHOBLASTIC LEUKEMIA Experimental Hematology. 76: e3. DOI: 10.1016/J.Exphem.2019.09.011  0.454
2019 Eaves C, Bulaeva E, Knapp D, Hammond C, Pellacani D, Nakamichi N, Sloma I, Lorzadeh A, Beer P, Wilhelm B, Weng A, Hirst M. 1032 - PROSPECTIVE ANALYSIS OF THE HUMAN LEUKEMOGENIC PROCESS Experimental Hematology. 76: S38. DOI: 10.1016/J.Exphem.2019.06.270  0.492
2018 Nguyen LV, Makarem M, Kannan N, Carles A, Balani S, Moksa M, Hirst M, Eaves CJ. Clonal analysis of mouse mammary luminal epithelial cell transplants. Stem Cells and Development. PMID 30572802 DOI: 10.1089/Scd.2018.0158  0.477
2018 Eaves CJ. A Prospective Analysis of Human Leukemogenesis. Stem Cell Reports. 11: 1034-1039. PMID 30428386 DOI: 10.1016/J.Stemcr.2018.10.016  0.453
2018 Giambra V, Gusscott S, Gracias D, Song R, Lam SH, Panelli P, Tyshchenko K, Jenkins CE, Hoofd C, Lorzadeh A, Carles A, Hirst M, Eaves CJ, Weng AP. Epigenetic Restoration of Fetal-like IGF1 Signaling Inhibits Leukemia Stem Cell Activity. Cell Stem Cell. PMID 30269902 DOI: 10.1016/J.Stem.2018.08.018  0.571
2018 Ngom M, Imren S, Maetzig T, Adair JE, Knapp DJHF, Chagraoui J, Fares I, Bordeleau ME, Sauvageau G, Leboulch P, Eaves C, Humphries RK. UM171 Enhances Lentiviral Gene Transfer and Recovery of Primitive Human Hematopoietic Cells. Molecular Therapy. Methods & Clinical Development. 10: 156-164. PMID 30101153 DOI: 10.1016/J.Omtm.2018.06.009  0.554
2018 Hui T, Cao Q, Wegrzyn-Woltosz J, O'Neill K, Hammond CA, Knapp DJHF, Laks E, Moksa M, Aparicio S, Eaves CJ, Karsan A, Hirst M. High-Resolution Single-Cell DNA Methylation Measurements Reveal Epigenetically Distinct Hematopoietic Stem Cell Subpopulations. Stem Cell Reports. PMID 30078558 DOI: 10.1016/J.Stemcr.2018.07.003  0.509
2018 Kannan N, Eaves CJ. Macrophages stimulate mammary stem cells. Science (New York, N.Y.). 360: 1401-1402. PMID 29954968 DOI: 10.1126/Science.Aau1394  0.529
2018 Gusterson B, Eaves CJ. Basal-like Breast Cancers: From Pathology to Biology and Back Again. Stem Cell Reports. 10: 1676-1686. PMID 29874626 DOI: 10.1016/J.Stemcr.2018.04.023  0.414
2018 Aghaeepour N, Simonds EF, Knapp DJHF, Bruggner R, Sachs K, Culos A, Gherardini PF, Samusik N, Fragiadakis G, Bendall S, Gaudilliere B, Angst MS, Eaves CJ, Weiss WA, Fantl W, et al. GateFinder: Projection-based Gating Strategy Optimization for Flow and Mass Cytometry. Bioinformatics (Oxford, England). PMID 29850785 DOI: 10.1093/Bioinformatics/Bty430  0.339
2018 Knapp DJHF, Hammond CA, Hui T, van Loenhout MTJ, Wang F, Aghaeepour N, Miller PH, Moksa M, Rabu GM, Beer PA, Pellacani D, Humphries RK, Hansen C, Hirst M, Eaves CJ. Single-cell analysis identifies a CD33 subset of human cord blood cells with high regenerative potential. Nature Cell Biology. 20: 710-720. PMID 29802403 DOI: 10.1038/S41556-018-0104-5  0.572
2018 Wong PPC, Kariminia A, Jones D, Eaves CJ, Foley R, Ivison S, Couban S, Schultz KR. Plerixafor effectively mobilizes CD56 NK cells in blood providing an allograft predicted to protect against GvHD. Blood. PMID 29728400 DOI: 10.1182/Blood-2018-03-836700  0.482
2018 Lai D, Chen M, Su J, Liu X, Rothe K, Hu K, Forrest DL, Eaves CJ, Morin GB, Jiang X. PP2A inhibition sensitizes cancer stem cells to ABL tyrosine kinase inhibitors in BCR-ABL+ human leukemia. Science Translational Medicine. 10. PMID 29437150 DOI: 10.1126/Scitranslmed.Aan8735  0.445
2018 Kusakabe M, Sun AC, Tyshchenko K, Wong R, Nanda A, Shanna C, Gusscott S, Chavez E, Lorzadeh A, Zhu A, Hill A, Hung S, Brown S, Babaian A, Wang X, ... ... Eaves CJ, et al. Synthetic De Novo Modeling of Human T-Cell Acute Lymphoblastic Leukemia Reveals HOXB Genes Drive Expansion of Leukemia Cells-of-Origin and Established Tumor Clones Blood. 132: 1322-1322. DOI: 10.1182/Blood-2018-99-120120  0.486
2018 Wu A, Hanyang L, Rothe K, Chen M, Ruschmann J, Petriv O, O'Neill K, Maetzig T, Knapp D, Nakamichi N, Brinkman R, Birol I, Forrest DL, Hansen C, Humphries RK, ... Eaves CJ, et al. Global Transcriptome Profiling Identifies a Key Mir-185-PAK6 Axis That Promotes Survival of Leukemic Stem Cells and Drug-Insensitive Blasts in BCR-ABL+ Human Leukemia Blood. 132: 931-931. DOI: 10.1182/Blood-2018-99-113559  0.413
2018 Than H, Nakamichi N, Pomicter AD, O'Shea J, Antelope O, O'Hare T, Eaves CJ, Deininger MW. Genotypic Representation of Myelodysplastic/Myeloproliferative Neoplasms in Nrg, Nrg-3GS and Srg-W41 Mice with Transgenic Expression of Human Cytokines Blood. 132: 2038-2038. DOI: 10.1182/Blood-2018-99-111728  0.525
2017 Chatterjee S, Basak P, Buchel E, Safneck J, Murphy LC, Mowat M, Kung SK, Eirew P, Eaves CJ, Raouf A. Breast Cancers Activate Stromal Fibroblast-Induced Suppression of Progenitors in Adjacent Normal Tissue. Stem Cell Reports. PMID 29233553 DOI: 10.1016/J.Stemcr.2017.11.002  0.481
2017 Knapp DJHF, Kannan N, Pellacani D, Eaves CJ. Mass Cytometric Analysis Reveals Viable Activated Caspase-3(+) Luminal Progenitors in the Normal Adult Human Mammary Gland. Cell Reports. 21: 1116-1126. PMID 29069592 DOI: 10.1016/J.Celrep.2017.09.096  0.477
2017 Lan X, Jörg DJ, Cavalli FMG, Richards LM, Nguyen LV, Vanner RJ, Guilhamon P, Lee L, Kushida MM, Pellacani D, Park NI, Coutinho FJ, Whetstone H, Selvadurai HJ, Che C, ... ... Eaves CJ, et al. Fate mapping of human glioblastoma reveals an invariant stem cell hierarchy. Nature. PMID 28854171 DOI: 10.1038/Nature23666  0.575
2017 Sloma I, Mitjavila-Garcia M, Feraud O, Griscelli F, Oudrhiri N, El Marsafy S, Gobbo E, Divers D, Proust A, Smadja DM, Desterke C, Carles A, Ma Y, Hirst M, Marra MA, ... Eaves CJ, et al. Whole genome analysis reveals unexpected dynamics of mutant subclone development in a patient with JAK2-V617F-positive chronic myeloid leukemia. Experimental Hematology. PMID 28602946 DOI: 10.1016/J.Exphem.2017.05.007  0.454
2017 Balani S, Nguyen LV, Eaves CJ. Modeling the process of human tumorigenesis. Nature Communications. 8: 15422. PMID 28541307 DOI: 10.1038/Ncomms15422  0.447
2017 Sasaki T, Rivera-Mulia JC, Vera D, Zimmerman J, Das S, Padget M, Nakamichi N, Chang BH, Tyner J, Druker BJ, Weng AP, Civin CI, Eaves CJ, Gilbert DM. Stability of patient-specific features of altered DNA replication timing in xenografts of primary human acute lymphoblastic leukemia. Experimental Hematology. PMID 28433605 DOI: 10.1016/J.Exphem.2017.04.004  0.446
2017 He Z, Kannan N, Nemirovsky O, Chen H, Connell M, Taylor B, Jiang J, Pilarski LM, Fleisch MC, Niederacher D, Pujana MA, Eaves CJ, Maxwell CA. BRCA1 controls the cell division axis and governs ploidy and phenotype in human mammary cells. Oncotarget. PMID 28427147 DOI: 10.18632/Oncotarget.15688  0.538
2017 Miller PH, Rabu G, MacAldaz M, Knapp DJ, Cheung AM, Dhillon K, Nakamichi N, Beer PA, Shultz LD, Humphries RK, Eaves CJ. Analysis of parameters that affect human hematopoietic cell outputs in mutant c-kit immunodeficient mice. Experimental Hematology. PMID 28087429 DOI: 10.1016/J.Exphem.2016.12.012  0.467
2017 Knapp DJ, Hammond CA, Miller PH, Rabu GM, Beer PA, Ricicova M, Lecault V, Da Costa D, VanInsberghe M, Cheung AM, Pellacani D, Piret J, Hansen C, Eaves CJ. Dissociation of Survival, Proliferation, and State Control in Human Hematopoietic Stem Cells. Stem Cell Reports. 8: 152-162. PMID 28076756 DOI: 10.1016/J.Stemcr.2016.12.003  0.674
2017 He Z, Nemirovsky O, Kannan N, Eaves C, Maxwell CA. Abstract 3459: BRCA1 controls the cell division axis and governs ploidy and phenotype in human mammary cells Cancer Research. 77: 3459-3459. DOI: 10.1158/1538-7445.Am2017-3459  0.503
2017 Bulaeva E, Nakamichi N, Beer P, Weng A, Eaves C. Generation of a new, human growth factor-dependent, de novo model of AML from c-MYC-transduced normal human CD34+ hematopoietic cells Experimental Hematology. 53: S120. DOI: 10.1016/J.Exphem.2017.06.301  0.434
2017 MacAldaz M, AbolHasani B, Miller P, Kardel M, Welte K, Skokowa J, Bennaceur-Griscelli A, Turhan A, Eaves C. Characterization of hematopoietic cells generated from normal and leukemic human induced pluripotent stem cells (hiPSCs) in teratomas Experimental Hematology. 53: S80-S81. DOI: 10.1016/j.exphem.2017.06.176  0.482
2017 Rothe K, Babaian A, Nakamichi N, Chen M, Forrest D, Dedhar S, Eaves C, Jiang X. Targeting ILK impairs TKI-resistance of quiescent leukemic stem cells in vitro and in vivo Experimental Hematology. 53: S69. DOI: 10.1016/J.Exphem.2017.06.136  0.45
2017 Eaves C, Knapp D, Hammond C, Hui A, van Loenhout M, Pellacani D, Wang F, Miller P, Lorzadeh A, Aghaeepour N, Moksa M, Vaninsberghe M, Rabu G, Beer P, Humphries R, et al. Molecular and biological analysis of human hematopoietic stem cells at single-cell resolution Experimental Hematology. 53: S24. DOI: 10.1016/J.Exphem.2017.06.010  0.557
2016 Lorzadeh A, Bilenky M, Hammond C, Knapp DJ, Li L, Miller PH, Carles A, Heravi-Moussavi A, Gakkhar S, Moksa M, Eaves CJ, Hirst M. Nucleosome Density ChIP-Seq Identifies Distinct Chromatin Modification Signatures Associated with MNase Accessibility. Cell Reports. 17: 2112-2124. PMID 27851972 DOI: 10.1016/J.Celrep.2016.10.055  0.353
2016 Pellacani D, Bilenky M, Kannan N, Heravi-Moussavi A, Knapp DJ, Gakkhar S, Moksa M, Carles A, Moore R, Mungall AJ, Marra MA, Jones SJ, Aparicio S, Hirst M, Eaves CJ. Analysis of Normal Human Mammary Epigenomes Reveals Cell-Specific Active Enhancer States and Associated Transcription Factor Networks. Cell Reports. 17: 2060-2074. PMID 27851968 DOI: 10.1016/J.Celrep.2016.10.058  0.467
2016 Knapp DJ, Hammond CA, Aghaeepour N, Miller PH, Pellacani D, Beer PA, Sachs K, Qiao W, Wang W, Humphries RK, Sauvageau G, Zandstra PW, Bendall SC, Nolan GP, Hansen C, ... Eaves CJ, et al. Distinct signaling programs control human hematopoietic stem cell survival and proliferation. Blood. PMID 27827829 DOI: 10.1182/Blood-2016-09-740654  0.707
2016 Sawai CM, Babovic S, Upadhaya S, Knapp DJ, Lavin Y, Lau CM, Goloborodko A, Feng J, Fujisaki J, Ding L, Mirny LA, Merad M, Eaves CJ, Reizis B. Hematopoietic Stem Cells Are the Major Source of Multilineage Hematopoiesis in Adult Animals. Immunity. PMID 27590115 DOI: 10.1016/J.Immuni.2016.08.007  0.55
2016 Kent DG, Dykstra BJ, Eaves CJ. Isolation and Assessment of Single Long-Term Reconstituting Hematopoietic Stem Cells from Adult Mouse Bone Marrow. Current Protocols in Stem Cell Biology. 38: 2A.4.1-2A.4.24. PMID 27532815 DOI: 10.1002/cpsc.10  0.464
2016 Miller PH, Nakamichi N, Knapp DJ, Rabu G, Schultz KR, Jones DM, Couban S, Eaves CJ. Quantitation of Human Cells That Produce Neutrophils and Platelets in Vivo Obtained From Normal Donors Treated with G-CSF and/or Plerixafor. Biology of Blood and Marrow Transplantation : Journal of the American Society For Blood and Marrow Transplantation. PMID 27496214 DOI: 10.1016/J.Bbmt.2016.07.023  0.514
2016 Miller PH, Knapp DJ, Beer PA, MacAldaz M, Rabu G, Cheung AM, Wei L, Eaves CJ. Early production of human neutrophils and platelets post-transplant is severely compromised by growth factor exposure. Experimental Hematology. PMID 27090409 DOI: 10.1016/J.Exphem.2016.04.003  0.496
2016 Rothe K, Babaian A, Nakamichi N, Chen M, Watanabe A, Mager D, Eaves CJ, Dedhar S, Jiang X. The Focal Adhesion Complex Ilk-Pinch-Parvin Is Key to Niche Interactions and Survival of Quiescent Stem Cells in Chronic Myeloid Leukemia In Vitro and In Vivo Blood. 128: 936-936. DOI: 10.1182/Blood.V128.22.936.936  0.593
2016 Nakamichi N, Hammond CA, Miller PH, Rothe K, Beer PA, Jiang X, Deininger MW, Eaves CJ. Enhanced and Accelerated Repopulation of Mutant C-Kit Immunodeficient Mice By Transplants of Primary Chronic and Acute Myeloid Leukemic Human Cells Blood. 128: 4537-4537. DOI: 10.1182/Blood.V128.22.4537.4537  0.456
2016 Lefort S, Pellacani D, Nguyen L, Eaves CJ. Abstract B45: De novo generation of highly aggressive human breast tumors by rapid serial passaging of oncogene-transduced starting populations of purified normal cells Molecular Cancer Research. 14. DOI: 10.1158/1557-3125.Advbc15-B45  0.494
2016 Balani S, Kannan N, Nguyen LV, Lefort S, Pellacani D, Eaves CJ. Abstract A63: Clonal analysis of normal and malignant human mammary epithelial cell responsiveness to radiation Molecular Cancer Research. 14. DOI: 10.1158/1557-3125.Advbc15-A63  0.496
2016 Kannan N, Shih K, Dong Y, Eirew P, Knapp D, Pellacani D, Wang H, Zeng H, Eaves C. Abstract A23: Human mammary luminal progenitor cells use cKIT-H2O2 interactions to regulate their growth Molecular Cancer Research. 14. DOI: 10.1158/1557-3125.Advbc15-A23  0.479
2016 Eaves CJ, Nguyen L, Pellacani D, Kannan N, Lefort S, Balani S, Cox C, Osako T, Aparicio S, Hirst M. Abstract IA13: Clonal dynamics of normal and malignant human mammary cell growth in xenografts Cancer Research. 76. DOI: 10.1158/1538-7445.Fbcr15-Ia13  0.453
2016 MacAldaz M, Miller P, Kardel M, Eaves C, Bennaceur-Griscelli A, Turhan A. Analysis of hematopoietic cells generated from human induced pluripotent stem cells differentiating in teratomas Experimental Hematology. 44: S88. DOI: 10.1016/J.Exphem.2016.06.181  0.562
2015 Beer PA, Eaves CJ. Modeling Normal and Disordered Human Hematopoiesis. Trends in Cancer. 1: 199-210. PMID 28741474 DOI: 10.1016/J.Trecan.2015.09.002  0.471
2015 Nguyen LV, Pellacani D, Lefort S, Kannan N, Osako T, Makarem M, Cox CL, Kennedy W, Beer P, Carles A, Moksa M, Bilenky M, Balani S, Babovic S, Sun I, ... ... Eaves CJ, et al. Barcoding reveals complex clonal dynamics of de novo transformed human mammary cells. Nature. PMID 26633636 DOI: 10.1038/Nature15742  0.467
2015 Kang SY, Kannan N, Zhang L, Martinez V, Rosin MP, Eaves CJ. Characterization of Epithelial Progenitors in Normal Human Palatine Tonsils and Their HPV16 E6/E7-Induced Perturbation. Stem Cell Reports. PMID 26527383 DOI: 10.1016/J.Stemcr.2015.09.020  0.494
2015 Joshi PA, Waterhouse PD, Kannan N, Narala S, Fang H, Di Grappa MA, Jackson HW, Penninger JM, Eaves C, Khokha R. RANK Signaling Amplifies WNT-Responsive Mammary Progenitors through R-SPONDIN1. Stem Cell Reports. 5: 31-44. PMID 26095608 DOI: 10.1016/J.Stemcr.2015.05.012  0.462
2015 Patenaude A, Woerher S, Umlandt P, Wong F, Ibrahim R, Kyle A, Unger S, Fuller M, Parker J, Minchinton A, Eaves CJ, Karsan A. A novel population of local pericyte precursor cells in tumor stroma that require Notch signaling for differentiation. Microvascular Research. 101: 38-47. PMID 26092680 DOI: 10.1016/J.Mvr.2015.05.004  0.414
2015 Sikorski DJ, Caron NJ, VanInsberghe M, Zahn H, Eaves CJ, Piret JM, Hansen CL. Clonal analysis of individual human embryonic stem cell differentiation patterns in microfluidic cultures. Biotechnology Journal. 10: 1546-54. PMID 26059045 DOI: 10.1002/Biot.201500035  0.68
2015 Cole A, Wang Z, Coyaud E, Voisin V, Gronda M, Jitkova Y, Mattson R, Hurren R, Babovic S, Maclean N, Restall I, Wang X, Jeyaraju DV, Sukhai MA, Prabha S, ... ... Eaves CJ, et al. Inhibition of the Mitochondrial Protease ClpP as a Therapeutic Strategy for Human Acute Myeloid Leukemia. Cancer Cell. 27: 864-76. PMID 26058080 DOI: 10.1016/J.Ccell.2015.05.004  0.396
2015 von Palffy S, Bulaeva E, Babovic S, Kannan N, Knapp DJ, Wei L, Eaves CJ, Beer PA. Dominant-negative IKAROS enhances IL-3-stimulated signaling in wild-type but not BCR-ABL1(+) mouse BA/F3 cells. Experimental Hematology. 43: 514-523.e2. PMID 25951974 DOI: 10.1016/J.Exphem.2015.04.004  0.436
2015 Eaves CJ. Hematopoietic stem cells: concepts, definitions, and the new reality. Blood. 125: 2605-13. PMID 25762175 DOI: 10.1182/Blood-2014-12-570200  0.554
2015 Burleigh A, McKinney S, Brimhall J, Yap D, Eirew P, Poon S, Ng V, Wan A, Prentice L, Annab L, Barrett JC, Caldas C, Eaves C, Aparicio S. A co-culture genome-wide RNAi screen with mammary epithelial cells reveals transmembrane signals required for growth and differentiation. Breast Cancer Research : Bcr. 17: 4. PMID 25572802 DOI: 10.1186/S13058-014-0510-Y  0.374
2015 Eirew P, Steif A, Khattra J, Ha G, Yap D, Farahani H, Gelmon K, Chia S, Mar C, Wan A, Laks E, Biele J, Shumansky K, Rosner J, McPherson A, ... ... Eaves CJ, et al. Dynamics of genomic clones in breast cancer patient xenografts at single-cell resolution. Nature. 518: 422-6. PMID 25470049 DOI: 10.1038/Nature13952  0.328
2015 Beer PA, Knapp DJ, Miller PH, Kannan N, Sloma I, Heel K, Babovic S, Bulaeva E, Rabu G, Terry J, Druker BJ, Loriaux MM, Loeb KR, Radich JP, Erber WN, ... Eaves CJ, et al. Disruption of IKAROS activity in primitive chronic-phase CML cells mimics myeloid disease progression. Blood. 125: 504-15. PMID 25370416 DOI: 10.1182/Blood-2014-06-581173  0.441
2015 Zhang X, Ma W, Cui J, Yao H, Zhou H, Ge Y, Xiao L, Hu X, Liu BH, Yang J, Li YY, Chen S, Eaves CJ, Wu D, Zhao Y. Regulation of p21 by TWIST2 contributes to its tumor-suppressor function in human acute myeloid leukemia. Oncogene. 34: 3000-10. PMID 25088197 DOI: 10.1038/onc.2014.241  0.313
2015 Giambra V, Lam SH, Belmonte M, Gusscott S, Salehi S, Chan FC, Kridel R, Lorzadeh A, Hoofd C, Steidl C, Eaves CJ, Hirst M, Weng AP. NOTCH1 Induces Differential Epigenomic Patterning and Genomic Organization in Fetal Liver- and Adult Bone Marrow-Derived Hematopoietic Progentiors Blood. 126: 3637-3637. DOI: 10.1182/Blood.V126.23.3637.3637  0.437
2015 Lin H, Zeng J, Rothe K, Ruschmann J, Petriv O, O'Neill K, Maetzig T, Knapp D, Brinkman RR, Birol I, Forrest DL, Hansen C, Eaves CJ, Humphries RK, Jiang X. Identification and Characterization of New Microrna Biomarkers and Target Genes in Drug-Insensitive CD34+ CML Stem/Progenitor Cells Using Global Comparative RNA-Seq Analyses Blood. 126: 1567-1567. DOI: 10.1182/Blood.V126.23.1567.1567  0.356
2015 Rothe K, Watanabe A, Forrest D, Dedhar S, Eaves C, Jiang X. The focal adhesion protein ilk is key to niche interactions and survival of CML stem cells Experimental Hematology. 43: S91. DOI: 10.1016/J.Exphem.2015.06.240  0.439
2015 Lin H, Rothe K, Ruschmann J, Petriv O, O'Neill K, Knapp D, Brinkman R, Birol I, Forrest D, Hansen C, Eaves C, Humphries K, Jiang X. Comparative RNA-seq analyses identify new microRNA biomarkers and candidate target genes in patients’ drug-resistant CD34+ CML stem/progenitor cells Experimental Hematology. 43: S63. DOI: 10.1016/J.Exphem.2015.06.122  0.403
2015 Sikorski DJ, Caron NJ, Vaninsberghe M, Zahn H, Eaves CJ, Piret JM, Hansen CL. Clonal analysis of individual human embryonic stem cell differentiation patterns in microfluidic cultures Biotechnology Journal. DOI: 10.1002/biot.201500035  0.672
2014 Nguyen LV, Cox CL, Eirew P, Knapp DJ, Pellacani D, Kannan N, Carles A, Moksa M, Balani S, Shah S, Hirst M, Aparicio S, Eaves CJ. DNA barcoding reveals diverse growth kinetics of human breast tumour subclones in serially passaged xenografts. Nature Communications. 5: 5871. PMID 25532760 DOI: 10.1038/Ncomms6871  0.313
2014 Beer PA, Knapp DJ, Kannan N, Miller PH, Babovic S, Bulaeva E, Aghaeepour N, Rabu G, Rostamirad S, Shih K, Wei L, Eaves CJ. A dominant-negative isoform of IKAROS expands primitive normal human hematopoietic cells. Stem Cell Reports. 3: 841-57. PMID 25418728 DOI: 10.1016/J.Stemcr.2014.09.006  0.578
2014 Lai CK, Moon Y, Kuchenbauer F, Starzcynowski DT, Argiropoulos B, Yung E, Beer P, Schwarzer A, Sharma A, Park G, Leung M, Lin G, Vollett S, Fung S, Eaves CJ, et al. Cell fate decisions in malignant hematopoiesis: leukemia phenotype is determined by distinct functional domains of the MN1 oncogene. Plos One. 9: e112671. PMID 25401736 DOI: 10.1371/Journal.Pone.0112671  0.415
2014 Imren S, Heuser M, Gasparetto M, Beer PA, Norddahl GL, Xiang P, Chen L, Berg T, Rhyasen GW, Rosten P, Park G, Moon Y, Weng AP, Eaves CJ, Humphries RK. Modeling de novo leukemogenesis from human cord blood with MN1 and NUP98HOXD13. Blood. 124: 3608-12. PMID 25339361 DOI: 10.1182/Blood-2014-04-564666  0.534
2014 Chakrabarti R, Wei Y, Hwang J, Hang X, Andres Blanco M, Choudhury A, Tiede B, Romano RA, DeCoste C, Mercatali L, Ibrahim T, Amadori D, Kannan N, Eaves CJ, Sinha S, et al. ΔNp63 promotes stem cell activity in mammary gland development and basal-like breast cancer by enhancing Fzd7 expression and Wnt signalling. Nature Cell Biology. 16: 1004-15, 1-13. PMID 25241036 DOI: 10.1038/Ncb3040  0.483
2014 Fares I, Chagraoui J, Gareau Y, Gingras S, Ruel R, Mayotte N, Csaszar E, Knapp DJ, Miller P, Ngom M, Imren S, Roy DC, Watts KL, Kiem HP, Herrington R, ... ... Eaves CJ, et al. Cord blood expansion. Pyrimidoindole derivatives are agonists of human hematopoietic stem cell self-renewal. Science (New York, N.Y.). 345: 1509-12. PMID 25237102 DOI: 10.1126/Science.1256337  0.707
2014 Babovic S, Eaves CJ. Hierarchical organization of fetal and adult hematopoietic stem cells. Experimental Cell Research. 329: 185-91. PMID 25128815 DOI: 10.1016/J.Yexcr.2014.08.005  0.554
2014 Kannan N, Eaves CJ. Tipping the balance: MTDH-SND1 curbs oncogene-induced apoptosis and promotes tumorigenesis. Cell Stem Cell. 15: 118-20. PMID 25105576 DOI: 10.1016/J.Stem.2014.07.010  0.302
2014 Kannan N, Nguyen LV, Eaves CJ. Integrin β3 links therapy resistance and cancer stem cell properties. Nature Cell Biology. 16: 397-9. PMID 24914436 DOI: 10.1038/Ncb2960  0.444
2014 Wohrer S, Knapp DJ, Copley MR, Benz C, Kent DG, Rowe K, Babovic S, Mader H, Oostendorp RA, Eaves CJ. Distinct stromal cell factor combinations can separately control hematopoietic stem cell survival, proliferation, and self-renewal. Cell Reports. 7: 1956-67. PMID 24910437 DOI: 10.1016/J.Celrep.2014.05.014  0.524
2014 Kannan N, Nguyen LV, Makarem M, Dong Y, Shih K, Eirew P, Raouf A, Emerman JT, Eaves CJ. Glutathione-dependent and -independent oxidative stress-control mechanisms distinguish normal human mammary epithelial cell subsets. Proceedings of the National Academy of Sciences of the United States of America. 111: 7789-94. PMID 24821780 DOI: 10.1073/Pnas.1403813111  0.46
2014 Zhou H, Ge Y, Sun L, Ma W, Wu J, Zhang X, Hu X, Eaves CJ, Wu D, Zhao Y. Growth arrest specific 2 is up-regulated in chronic myeloid leukemia cells and required for their growth. Plos One. 9: e86195. PMID 24465953 DOI: 10.1371/Journal.Pone.0086195  0.525
2014 Nguyen LV, Makarem M, Carles A, Moksa M, Kannan N, Pandoh P, Eirew P, Osako T, Kardel M, Cheung AM, Kennedy W, Tse K, Zeng T, Zhao Y, Humphries RK, ... ... Eaves CJ, et al. Clonal analysis via barcoding reveals diverse growth and differentiation of transplanted mouse and human mammary stem cells. Cell Stem Cell. 14: 253-63. PMID 24440600 DOI: 10.1016/J.Stem.2013.12.011  0.529
2014 Knapp DJ, Eaves CJ. Control of the hematopoietic stem cell state. Cell Research. 24: 3-4. PMID 24100350 DOI: 10.1038/Cr.2013.139  0.505
2014 Fares I, Chagaroui J, Gareau Y, Gingras S, Mayotte N, Csaszar E, Kiem H, Iscove NN, Humphries RK, Eaves CJ, Cohen S, Marinier A, Zandstra PW, Sauvageau G. Pyrimido-Indole Derivatives Are Novel Agonists of Human Cord Blood Hematopoietic Stem Cell Self-Renewal Blood. 124: 650-650. DOI: 10.1182/Blood.V124.21.650.650  0.739
2014 Miller PH, Nakamichi N, Rabu G, Schultz KR, Jones DM, Couban S, Eaves CJ. Prior Granulocyte Colony-Stimulating Factor Treatment Enhances the Immediate and Transient Output of Primitive Hematopoietic Cells in the Blood of Normal Adult Human Donors Treated with Plerixafor Blood. 124: 5787-5787. DOI: 10.1182/Blood.V124.21.5787.5787  0.472
2014 Rothe K, Watanabe A, Forrest DL, Dedhar S, Eaves CJ, Jiang X. Integrin-Linked Kinase As a Key Mediator of Stromal Cell-Enhanced Resistance of Primitive CML Cells to Tyrosine Kinase Inhibitors Blood. 124: 402-402. DOI: 10.1182/Blood.V124.21.402.402  0.557
2014 Lam SSY, Cher CY, Ng NKL, Ho ES, Man CH, Chow HC, Eaves CJ, Cheung AM, Leung AY. Development of a Clinically Relevant in Vitro Drug Screening Platform for Chemo-Refractory AML Patients Blood. 124: 3624-3624. DOI: 10.1182/Blood.V124.21.3624.3624  0.384
2014 Lin H, Rothe K, Ruschmann J, Petriv O, O'Neill K, Knapp DJ, Brinkman RR, Birol I, Forrest DL, Hansen C, Eaves CJ, Humphries RK, Jiang X. Identification of New microRNA Biomarkers and Candidate Target Genes in Primitive CML Cells Using Global Comparative RNA analyses Blood. 124: 3133-3133. DOI: 10.1182/Blood.V124.21.3133.3133  0.392
2014 Miller PH, Rabu G, Knapp DJ, Cheung AM, Dhillon K, Beer PA, Eaves CJ. Longterm Multilineage Human Hematopoietic Repopulation of Untreated KIT-Mutant Immunodeficient Mice Blood. 124: 2415-2415. DOI: 10.1182/Blood.V124.21.2415.2415  0.497
2014 Kannan N, Knapp D, Shih K, Dong Y, Eirew P, Wang H, Nguyen L, Makarem M, Pellacani D, Lefort S, Balani S, Beer P, Zeng H, Eaves C. Elevated ROS Activates KIT, a Lineage-Specific Signaling Receptor in Normal Human Mammary Epithelial Cells Free Radical Biology and Medicine. 76: S149. DOI: 10.1016/J.Freeradbiomed.2014.10.558  0.423
2014 Babovic S, Knapp D, Beer P, Nakamichi N, Copley M, Eaves C. Developmental downregulation of LIN28 and HMGA2 expression in primitive normal human hematopoietic cells Experimental Hematology. 42: S23. DOI: 10.1016/J.Exphem.2014.07.080  0.487
2013 Copley MR, Eaves CJ. Developmental changes in hematopoietic stem cell properties. Experimental & Molecular Medicine. 45: e55. PMID 24232254 DOI: 10.1038/Emm.2013.98  0.556
2013 Kawamura E, Fielding AB, Kannan N, Balgi A, Eaves CJ, Roberge M, Dedhar S. Identification of novel small molecule inhibitors of centrosome clustering in cancer cells. Oncotarget. 4: 1763-76. PMID 24091544 DOI: 10.18632/Oncotarget.1198  0.415
2013 Kannan N, Huda N, Tu L, Droumeva R, Aubert G, Chavez E, Brinkman RR, Lansdorp P, Emerman J, Abe S, Eaves C, Gilley D. The luminal progenitor compartment of the normal human mammary gland constitutes a unique site of telomere dysfunction. Stem Cell Reports. 1: 28-37. PMID 24052939 DOI: 10.1016/J.Stemcr.2013.04.003  0.364
2013 Cheung AM, Nguyen LV, Carles A, Beer P, Miller PH, Knapp DJ, Dhillon K, Hirst M, Eaves CJ. Analysis of the clonal growth and differentiation dynamics of primitive barcoded human cord blood cells in NSG mice. Blood. 122: 3129-37. PMID 24030380 DOI: 10.1182/Blood-2013-06-508432  0.586
2013 Makarem M, Kannan N, Nguyen LV, Knapp DJ, Balani S, Prater MD, Stingl J, Raouf A, Nemirovsky O, Eirew P, Eaves CJ. Developmental changes in the in vitro activated regenerative activity of primitive mammary epithelial cells. Plos Biology. 11: e1001630. PMID 23966837 DOI: 10.1371/Journal.Pbio.1001630  0.577
2013 Sloma I, Beer PA, Saw KM, Chan M, Leung D, Raghuram K, Brimacombe C, Johnston B, Lambie K, Forrest D, Jiang X, Eaves CJ. Genotypic and functional diversity of phenotypically defined primitive hematopoietic cells in patients with chronic myeloid leukemia. Experimental Hematology. 41: 837-47. PMID 23851302 DOI: 10.1016/J.Exphem.2013.07.001  0.562
2013 Copley MR, Babovic S, Benz C, Knapp DJ, Beer PA, Kent DG, Wohrer S, Treloar DQ, Day C, Rowe K, Mader H, Kuchenbauer F, Humphries RK, Eaves CJ. The Lin28b-let-7-Hmga2 axis determines the higher self-renewal potential of fetal haematopoietic stem cells. Nature Cell Biology. 15: 916-25. PMID 23811688 DOI: 10.1038/Ncb2783  0.441
2013 Tubsuwan A, Abed S, Deichmann A, Kardel MD, Bartholomä C, Cheung A, Negre O, Kadri Z, Fucharoen S, von Kalle C, Payen E, Chrétien S, Schmidt M, Eaves CJ, Leboulch P, et al. Parallel assessment of globin lentiviral transfer in induced pluripotent stem cells and adult hematopoietic stem cells derived from the same transplanted β-thalassemia patient. Stem Cells (Dayton, Ohio). 31: 1785-94. PMID 23712774 DOI: 10.1002/Stem.1436  0.489
2013 Zeng F, Huang SZ, Gong ZJ, Chen MJ, Baldwin DA, Hu W, Qian H, Yan JB, Wang J, Xiao YP, Chalandon Y, Ringrose A, Ren ZR, Eaves A, Eaves C, et al. Long-term deregulated human hematopoiesis in goats transplanted in utero with BCR-ABL-transduced lin(-)CD34(+) cord blood cells. Cell Research. 23: 859-62. PMID 23628725 DOI: 10.1038/Cr.2013.60  0.434
2013 Makarem M, Spike BT, Dravis C, Kannan N, Wahl GM, Eaves CJ. Stem cells and the developing mammary gland. Journal of Mammary Gland Biology and Neoplasia. 18: 209-19. PMID 23624881 DOI: 10.1007/S10911-013-9284-6  0.579
2013 Miller PH, Knapp DJ, Eaves CJ. Heterogeneity in hematopoietic stem cell populations: implications for transplantation. Current Opinion in Hematology. 20: 257-64. PMID 23615054 DOI: 10.1097/Moh.0B013E328360Aaf6  0.554
2013 Caron NJ, Gage BK, O'Connor MD, Eaves CJ, Kieffer TJ, Piret JM. A human embryonic stem cell line adapted for high throughput screening. Biotechnology and Bioengineering. 110: 2706-16. PMID 23613129 DOI: 10.1002/Bit.24936  0.684
2013 Chen M, Gallipoli P, DeGeer D, Sloma I, Forrest DL, Chan M, Lai D, Jorgensen H, Ringrose A, Wang HM, Lambie K, Nakamoto H, Saw KM, Turhan A, Arlinghaus R, ... ... Eaves CJ, et al. Targeting primitive chronic myeloid leukemia cells by effective inhibition of a new AHI-1-BCR-ABL-JAK2 complex. Journal of the National Cancer Institute. 105: 405-23. PMID 23446755 DOI: 10.1093/Jnci/Djt006  0.442
2013 Valent P, Bonnet D, Wöhrer S, Andreeff M, Copland M, Chomienne C, Eaves C. Heterogeneity of neoplastic stem cells: theoretical, functional, and clinical implications. Cancer Research. 73: 1037-45. PMID 23345162 DOI: 10.1158/0008-5472.Can-12-3678  0.533
2013 Miller PH, Cheung AM, Beer PA, Knapp DJ, Dhillon K, Rabu G, Rostamirad S, Humphries RK, Eaves CJ. Enhanced normal short-term human myelopoiesis in mice engineered to express human-specific myeloid growth factors. Blood. 121: e1-4. PMID 23233660 DOI: 10.1182/Blood-2012-09-456566  0.507
2013 Sukhai MA, Prabha S, Hurren R, Rutledge AC, Lee AY, Sriskanthadevan S, Sun H, Wang X, Skrtic M, Seneviratne A, Cusimano M, Jhas B, Gronda M, MacLean N, Cho EE, ... ... Eaves C, et al. Lysosomal disruption preferentially targets acute myeloid leukemia cells and progenitors Journal of Clinical Investigation. 123: 315-328. PMID 23202731 DOI: 10.1172/Jci64180  0.5
2013 Woehrer S, Miller CL, Eaves CJ. Long-term culture-initiating cell assay for mouse cells. Methods in Molecular Biology (Clifton, N.J.). 946: 257-66. PMID 23179837 DOI: 10.1007/978-1-62703-128-8_16  0.547
2013 Liu M, Miller CL, Eaves CJ. Human long-term culture initiating cell assay. Methods in Molecular Biology (Clifton, N.J.). 946: 241-56. PMID 23179836 DOI: 10.1007/978-1-62703-128-8_15  0.485
2013 Sloma I, Imren S, Beer PA, Zhao Y, Lecault V, Leung D, Raghuram K, Brimacombe C, Lambie K, Piret J, Hansen C, Humphries RK, Eaves CJ. Ex vivo expansion of normal and chronic myeloid leukemic stem cells without functional alteration using a NUP98HOXA10homeodomain fusion gene. Leukemia. 27: 159-69. PMID 22868969 DOI: 10.1038/Leu.2012.196  0.741
2013 Sloma I, Mitjavila-Garcia MT, Feraud O, Oudrhiri N, Tosca L, El Marsafy S, Gobbo E, Divers D, Proust A, Griscelli F, Tachdjian G, Marra MA, Eaves CJ, Bennaceur-Griscelli A, Turhan AG. Whole Genome Sequencing Of Chronic Myeloid Leukemia (CML)-Derived Induced Pluripotent Stem Cells (iPSC) Reveals Faithful Genocopying Of Highly Mutated Primary Leukemic Cells Blood. 122: 514-514. DOI: 10.1182/Blood.V122.21.514.514  0.495
2013 Beer PA, Sloma I, Miller PH, Knapp DJ, Rabu G, Eaves CJ. Disruption Of Ikaros In Patients’ Chronic Phase CML Cells Induces The Features Of Accelerated Phase Disease Blood. 122: 513-513. DOI: 10.1182/Blood.V122.21.513.513  0.531
2013 Zhao Y, Ma W, Zhang X, Cui J, Sloma I, Zhou H, Wu D, Eaves CJ. A Novel TWIST2-ID2 Axis That Modulates The Growth and Imatinib Sensitivity Of CML CD34+ Cells Blood. 122: 511-511. DOI: 10.1182/Blood.V122.21.511.511  0.523
2013 Kannan N, Makarem M, Nguyen L, Dong J, Eirew P, Eaves C. Abstract 2919: Different ROS control mechanisms and mutagenic consequences in primitive subsets of normal human mammary cells. Cancer Research. 73: 2919-2919. DOI: 10.1158/1538-7445.Am2013-2919  0.447
2013 Kannan N, Makarem M, Nguyen L, Dong J, Shih K, Eirew P, Eaves C. Distinct ROS Control Mechanisms and their Mutagenic Consequences in Progenitor Subsets of Normal Human Mammary Gland Free Radical Biology and Medicine. 65: S21. DOI: 10.1016/J.Freeradbiomed.2013.10.432  0.36
2013 Woltosz JW, Knapp D, Copley M, Ibrahim R, Umlandt P, Fuller M, Baltimore D, Boldin M, Eaves C, Karsan A. miR-146a regulates hematopoietic stem cell maintenance and cell cycle entry Experimental Hematology. 41: S17. DOI: 10.1016/J.Exphem.2013.05.064  0.431
2012 Giambra V, Jenkins CR, Wang H, Lam SH, Shevchuk OO, Nemirovsky O, Wai C, Gusscott S, Chiang MY, Aster JC, Humphries RK, Eaves C, Weng AP. NOTCH1 promotes T cell leukemia-initiating activity by RUNX-mediated regulation of PKC-θ and reactive oxygen species. Nature Medicine. 18: 1693-8. PMID 23086478 DOI: 10.1038/Nm.2960  0.418
2012 Valent P, Bonnet D, De Maria R, Lapidot T, Copland M, Melo JV, Chomienne C, Ishikawa F, Schuringa JJ, Stassi G, Huntly B, Herrmann H, Soulier J, Roesch A, Schuurhuis GJ, ... ... Eaves C, et al. Cancer stem cell definitions and terminology: the devil is in the details. Nature Reviews. Cancer. 12: 767-75. PMID 23051844 DOI: 10.1038/Nrc3368  0.466
2012 Despeaux M, Chicanne G, Rouer E, De Toni-Costes F, Bertrand J, Mansat-De Mas V, Vergnolle N, Eaves C, Payrastre B, Girault JA, Racaud-Sultan C. Focal adhesion kinase splice variants maintain primitive acute myeloid leukemia cells through altered Wnt signaling. Stem Cells (Dayton, Ohio). 30: 1597-610. PMID 22714993 DOI: 10.1002/Stem.1157  0.516
2012 Copley MR, Beer PA, Eaves CJ. Hematopoietic stem cell heterogeneity takes center stage. Cell Stem Cell. 10: 690-7. PMID 22704509 DOI: 10.1016/J.Stem.2012.05.006  0.473
2012 Kardel MD, Eaves CJ. Modeling human hematopoietic cell development from pluripotent stem cells. Experimental Hematology. 40: 601-11. PMID 22510344 DOI: 10.1016/J.Exphem.2012.04.001  0.563
2012 Nieborowska-Skorska M, Kopinski PK, Ray R, Hoser G, Ngaba D, Flis S, Cramer K, Reddy MM, Koptyra M, Penserga T, Glodkowska-Mrowka E, Bolton E, Holyoake TL, Eaves CJ, Cerny-Reiterer S, et al. Rac2-MRC-cIII-generated ROS cause genomic instability in chronic myeloid leukemia stem cells and primitive progenitors. Blood. 119: 4253-63. PMID 22411871 DOI: 10.1182/Blood-2011-10-385658  0.395
2012 Benz C, Copley MR, Kent DG, Wohrer S, Cortes A, Aghaeepour N, Ma E, Mader H, Rowe K, Day C, Treloar D, Brinkman RR, Eaves CJ. Hematopoietic stem cell subtypes expand differentially during development and display distinct lymphopoietic programs. Cell Stem Cell. 10: 273-83. PMID 22385655 DOI: 10.1016/J.Stem.2012.02.007  0.538
2012 Cheung AM, Leung D, Rostamirad S, Dhillon K, Miller PH, Droumeva R, Brinkman RR, Hogge D, Roy DC, Eaves CJ. Distinct but phenotypically heterogeneous human cell populations produce rapid recovery of platelets and neutrophils after transplantation. Blood. 119: 3431-9. PMID 22374695 DOI: 10.1182/Blood-2011-12-398024  0.501
2012 Man CH, Fung TK, Ho C, Han HH, Chow HC, Ma AC, Choi WW, Lok S, Cheung AM, Eaves C, Kwong YL, Leung AY. Sorafenib treatment of FLT3-ITD(+) acute myeloid leukemia: favorable initial outcome and mechanisms of subsequent nonresponsiveness associated with the emergence of a D835 mutation. Blood. 119: 5133-43. PMID 22368270 DOI: 10.1182/Blood-2011-06-363960  0.368
2012 Serber DW, Rogala A, Makarem M, Rosson GB, Simin K, Godfrey V, Van Dyke T, Eaves CJ, Bultman SJ. The BRG1 chromatin remodeler protects against ovarian cysts, uterine tumors, and mammary tumors in a lineage-specific manner. Plos One. 7: e31346. PMID 22363625 DOI: 10.1371/Journal.Pone.0031346  0.386
2012 Nguyen LV, Vanner R, Dirks P, Eaves CJ. Cancer stem cells: an evolving concept. Nature Reviews. Cancer. 12: 133-43. PMID 22237392 DOI: 10.1038/Nrc3184  0.421
2012 Eirew P, Kannan N, Knapp DJ, Vaillant F, Emerman JT, Lindeman GJ, Visvader JE, Eaves CJ. Aldehyde dehydrogenase activity is a biomarker of primitive normal human mammary luminal cells. Stem Cells (Dayton, Ohio). 30: 344-8. PMID 22131125 DOI: 10.1002/Stem.1001  0.498
2012 Cheung AM, Nguyen LV, Carles A, Miller PH, Beer PA, Pandoh P, Knapp D, Dhillon K, Tse K, Zeng T, Zhao Y, Hirst M, Eaves CJ. Time Course Studies of the Progeny of Barcoded CD34+ Human Cord Blood Cells Generated in Transplanted NOD/SCID-IL2Rγ−/− Mice Unveil the Clonal Dynamics of Short Term, Intermediate Term and Long Term Repopulating Cells Blood. 120: 28-28. DOI: 10.1182/Blood.V120.21.28.28  0.578
2012 Sloma I, Beer PA, Saw KM, Chan M, Lambie K, Johnston B, Jiang X, Eaves CJ. Longterm Serial Transplantability of BCR-ABL+ Chronic Phase CML Cells Is Predicted by a 6-Week LTC-IC Assay. Blood. 120: 2770-2770. DOI: 10.1182/Blood.V120.21.2770.2770  0.548
2012 Giambra V, Lam SH, Ng A, Benz C, Shevchuk OO, Eaves CJ, Weng AP. Fetal Vs. Adult Hematopoietic Progenitors Respond Differently to NOTCH1: Implications for Pediatric Vs. Adult T-ALL. Blood. 120: 2381-2381. DOI: 10.1182/Blood.V120.21.2381.2381  0.413
2012 Knapp DJ, Bendall SC, Miller PH, Cheung AM, Imren S, Humphries RK, Brinkman RR, Oostendorp RA, Nolan GP, Eaves CJ. Short Term Signalling Responses of the Most Primitive Subsets of Human Hematopoietic Cells Stimulated in Vitro Correlate with Their Subsequent Self-Renewal Behaviour. Blood. 120: 2341-2341. DOI: 10.1182/Blood.V120.21.2341.2341  0.532
2012 Jiang X, Chen M, Gallipoli P, Lai D, Ringrose A, Turhan A, Eaves C, Holyoake T. 1009 Targeting Chronic Myeloid Leukemia Stem/progenitor Cells by Effective Inhibition of a Novel AHI-1-BCR-ABL-JAK2 Interaction Complex European Journal of Cancer. 48: S244. DOI: 10.1016/S0959-8049(12)71627-1  0.45
2011 Skrti? M, Sriskanthadevan S, Jhas B, Gebbia M, Wang X, Wang Z, Hurren R, Jitkova Y, Gronda M, Maclean N, Lai CK, Eberhard Y, Bartoszko J, Spagnuolo P, Rutledge AC, ... ... Eaves CJ, et al. Inhibition of mitochondrial translation as a therapeutic strategy for human acute myeloid leukemia. Cancer Cell. 20: 674-88. PMID 22094260 DOI: 10.1016/J.Ccr.2011.10.015  0.454
2011 Sekulovic S, Gasparetto M, Lecault V, Hoesli CA, Kent DG, Rosten P, Wan A, Brookes C, Hansen CL, Piret JM, Smith C, Eaves CJ, Humphries RK. Ontogeny stage-independent and high-level clonal expansion in vitro of mouse hematopoietic stem cells stimulated by an engineered NUP98-HOX fusion transcription factor. Blood. 118: 4366-76. PMID 21865344 DOI: 10.1182/Blood-2011-04-350066  0.731
2011 Heuser M, Yun H, Berg T, Yung E, Argiropoulos B, Kuchenbauer F, Park G, Hamwi I, Palmqvist L, Lai CK, Leung M, Lin G, Chaturvedi A, Thakur BK, Iwasaki M, ... ... Eaves C, et al. Cell of origin in AML: susceptibility to MN1-induced transformation is regulated by the MEIS1/AbdB-like HOX protein complex. Cancer Cell. 20: 39-52. PMID 21741595 DOI: 10.1016/J.Ccr.2011.06.020  0.349
2011 Sekulovic S, Gylfadottir V, Vulto I, Gasparetto M, Even Y, Brookes C, Smith C, Eaves CJ, Lansdorp PM, Rossi FM, Humphries RK. Prolonged self-renewal activity unmasks telomerase control of telomere homeostasis and function of mouse hematopoietic stem cells. Blood. 118: 1766-73. PMID 21730353 DOI: 10.1182/Blood-2010-11-319632  0.501
2011 O'Connor MD, Wederell E, Robertson G, Delaney A, Morozova O, Poon SS, Yap D, Fee J, Zhao Y, McDonald H, Zeng T, Hirst M, Marra MA, Aparicio SA, Eaves CJ. Retinoblastoma-binding proteins 4 and 9 are important for human pluripotent stem cell maintenance. Experimental Hematology. 39: 866-79.e1. PMID 21689726 DOI: 10.1016/J.Exphem.2011.05.008  0.542
2011 Eaves C, Eaves A. A fond farewell to Ernest A. McCulloch--a beacon who inspired generations of scientists and framed the foundation of modern stem cell biology. Experimental Hematology. 39: 602-3. PMID 21682007 DOI: 10.1016/J.Exphem.2011.02.012  0.505
2011 Lecault V, Vaninsberghe M, Sekulovic S, Knapp DJ, Wohrer S, Bowden W, Viel F, McLaughlin T, Jarandehei A, Miller M, Falconnet D, White AK, Kent DG, Copley MR, Taghipour F, ... Eaves CJ, et al. High-throughput analysis of single hematopoietic stem cell proliferation in microfluidic cell culture arrays. Nature Methods. 8: 581-6. PMID 21602799 DOI: 10.1038/Nmeth.1614  0.751
2011 Holland DG, Burleigh A, Git A, Goldgraben MA, Perez-Mancera PA, Chin SF, Hurtado A, Bruna A, Ali HR, Greenwood W, Dunning MJ, Samarajiwa S, Menon S, Rueda OM, Lynch AG, ... ... Eaves CJ, et al. ZNF703 is a common Luminal B breast cancer oncogene that differentially regulates luminal and basal progenitors in human mammary epithelium. Embo Molecular Medicine. 3: 167-80. PMID 21337521 DOI: 10.1002/Emmm.201100122  0.38
2011 O'Connor MD, Kardel MD, Eaves CJ. Functional assays for human embryonic stem cell pluripotency. Methods in Molecular Biology (Clifton, N.J.). 690: 67-80. PMID 21042985 DOI: 10.1007/978-1-60761-962-8_4  0.596
2011 Copley MR, Kent DG, Benz C, Wohrer S, Rowe KM, Day CW, Eaves CJ. Inhibition of Let-7 Processing in Adult Murine Hematopoietic Stem Cells Induces a Fetal-Like High Self-Renewal Pattern in Their Progeny Blood. 118: 45-45. DOI: 10.1182/Blood.V118.21.45.45  0.458
2011 Nieborowska-Skorska M, Kopinski P, Ray R, Hoser G, Ngaba D, Flis S, Cramer K, Reddy MM, Koptyra M, Penserga T, Glodkowska-Mrowka E, Ambrozek M, Seferynska I, Niesiobedzka-Krezel J, Bolton E, ... ... Eaves CJ, et al. Targeting Rac2 - Mitochondrial Respiratory Chain Complex III Signaling to Prevent Genomic Instability in Leukemia Stem and Progenitor Cells Blood. 118: 2736-2736. DOI: 10.1182/Blood.V118.21.2736.2736  0.418
2011 Skrtic M, Sriskanthadevan S, Livak B, Gebbia M, Wang X, Wang Z, Hurren R, Jitkova Y, Gronda M, Maclean N, Lai C, Eberhard Y, Bartoszko J, Spagnuolo PA, Rutledge A, ... ... Eaves CJ, et al. Inhibition of Mitochondrial Translation As a Therapeutic Strategy for Acute Myeloid Leukemia (AML) Blood. 118: 233-233. DOI: 10.1182/Blood.V118.21.233.233  0.51
2011 Miller PH, Cheung AM, Imren S, Beer PA, Rostamirad S, Dhillon K, Humphries RK, Eaves CJ. Distinct Human Cell Populations Produce Rapidly Detectable Levels of Neutrophils and Platelets in NOD/SCID-IL-2Receptor Gamma Chain Null Mice Transgenically Engineered to Produce Human Myeloid Growth Factors Blood. 118: 1892-1892. DOI: 10.1182/Blood.V118.21.1892.1892  0.536
2011 Benz C, Copley MR, Kent DG, Wohrer S, Eaves CJ. Early Appearance and Rapid, Selective Expansion of Lymphoid-Deficient Fetal HSCs Associated with Their Preferential Localization in the Marrow Blood. 118: 1271-1271. DOI: 10.1182/Blood.V118.21.1271.1271  0.446
2011 Cheung AM, Wohrer S, Miller PH, Imren S, Rostamirad S, Dhillon K, Knapp D, Oostendorp RA, Humphries RK, Eaves CJ. In Vitro Expansion of Human Hematopoietic Cells with Delayed but Sustained Multi-Lineage Repopulating Activity Blood. 118: 1270-1270. DOI: 10.1182/Blood.V118.21.1270.1270  0.6
2010 Eirew P, Stingl J, Eaves CJ. Quantitation of human mammary epithelial stem cells with in vivo regenerative properties using a subrenal capsule xenotransplantation assay. Nature Protocols. 5: 1945-56. PMID 21127488 DOI: 10.1038/Nprot.2010.148  0.558
2010 Martignani E, Eirew P, Accornero P, Eaves CJ, Baratta M. Human milk protein production in xenografts of genetically engineered bovine mammary epithelial stem cells. Plos One. 5: e13372. PMID 20976049 DOI: 10.1371/Journal.Pone.0013372  0.457
2010 Sloma I, Jiang X, Eaves AC, Eaves CJ. Insights into the stem cells of chronic myeloid leukemia. Leukemia. 24: 1823-33. PMID 20861912 DOI: 10.1038/leu.2010.159  0.427
2010 Law JH, Li Y, To K, Wang M, Astanehe A, Lambie K, Dhillon J, Jones SJ, Gleave ME, Eaves CJ, Dunn SE. Molecular decoy to the Y-box binding protein-1 suppresses the growth of breast and prostate cancer cells whilst sparing normal cell viability. Plos One. 5. PMID 20844753 DOI: 10.1371/Journal.Pone.0012661  0.401
2010 Jiang X, Forrest D, Nicolini F, Turhan A, Guilhot J, Yip C, Holyoake T, Jorgensen H, Lambie K, Saw KM, Pang E, Vukovic R, Lehn P, Ringrose A, Yu M, ... ... Eaves C, et al. Properties of CD34+ CML stem/progenitor cells that correlate with different clinical responses to imatinib mesylate. Blood. 116: 2112-21. PMID 20574046 DOI: 10.1182/Blood-2009-05-222471  0.481
2010 To K, Fotovati A, Reipas KM, Law JH, Hu K, Wang J, Astanehe A, Davies AH, Lee L, Stratford AL, Raouf A, Johnson P, Berquin IM, Royer HD, Eaves CJ, et al. Y-box binding protein-1 induces the expression of CD44 and CD49f leading to enhanced self-renewal, mammosphere growth, and drug resistance. Cancer Research. 70: 2840-51. PMID 20332234 DOI: 10.1158/0008-5472.Can-09-3155  0.4
2010 Rogers SL, Zhao Y, Jiang X, Eaves CJ, Mager DL, Rouhi A. Expression of the leukemic prognostic marker CD7 is linked to epigenetic modifications in chronic myeloid leukemia. Molecular Cancer. 9: 41. PMID 20175919 DOI: 10.1186/1476-4598-9-41  0.42
2010 Tacke M, Ball CR, Schmidt M, Klingenberg S, Maurer B, Fessler S, Eaves CJ, von Kalle C, Glimm H. The inherent differentiation program of short-term hematopoietic repopulating cells changes during human ontogeny. Stem Cells and Development. 19: 621-8. PMID 19788397 DOI: 10.1089/Scd.2009.0202  0.555
2010 Benz C, Copley MR, Kent D, Woehrer S, Rowe K, Eaves CJ. The Reduced Lymphopoietic Potential of a Novel Subclass of Hematopoietic Stem Cells Is Mediated by Specific Defects In the Production and Activity of Their Common Lymphoid Progenitor (CLP) Progeny Blood. 116: 576-576. DOI: 10.1182/Blood.V116.21.576.576  0.484
2010 Cheung AM, Eaves CJ. Differences In the Short Term Granulocyte and Platelet Producing Activity of Cord Blood and Mobilized Peripheral Blood Transplants Revealed by Quantitative Repopulation Assays In NOD/SCID-IL-2Rγc−/− Mice. Blood. 116: 3733-3733. DOI: 10.1182/Blood.V116.21.3733.3733  0.502
2010 DeGeer D, Gallipoli P, Chen M, Sloma I, Jorgensen H, Forrest D, Lambie K, Nakamoto H, Saw KM, Chan M, Newmarch K, Zhou L, Turhan AG, Arlinghaus RB, Eaves AC, ... Eaves CJ, et al. Combined Targeting of BCR-ABL and JAK2 with ABL and JAK2 Inhibitors Is Effective Against CML Patients' Leukemic Stem/Progenitor Cells. Blood. 116: 3404-3404. DOI: 10.1182/Blood.V116.21.3404.3404  0.534
2010 Jiang X, Grant H, Stebbing J, Foroni L, Craddock C, Griffiths M, Clark RE, O'Brien S, Khorashad JS, Gerrard G, Wang L, Irving J, Wang M, Karran L, Dyer MJ, ... ... Eaves CJ, et al. Analysis of BCR-ABL1 Tyrosine Kinase Domain Mutations In Primitive Chronic Myeloid Leukemia Cells Identifies a Unique Mutator Phenotype. Blood. 116: 3397-3397. DOI: 10.1182/Blood.V116.21.3397.3397  0.318
2010 Copley MR, Kent DG, Benz C, Rowe KM, Woehrer SH, Eaves CJ. Evidence That High-Mobility Group A2 (Hmga2) Expression Contributes to the Ontogeny-Dependent Properties of Fetal Hematopoietic Stem Cells. Blood. 116: 2634-2634. DOI: 10.1182/Blood.V116.21.2634.2634  0.525
2010 Wohrer S, Rowe K, Mader H, Benz C, Copley MR, Kent D, Oostendorp RA, Eaves CJ. Stromal Cell Regulation of Murine Hematopoietic Stem Cells. Blood. 116: 1566-1566. DOI: 10.1182/Blood.V116.21.1566.1566  0.562
2010 Giambra V, Nemirovsky O, Lam S, Jenkins C, Wai C, Medyouf H, Humphries RK, Eaves CJ, Weng AP. Notch-Mediated Suppression of PKCθ Reduces Reactive Oxygen Species and Promotes Leukemic Stem Cell Activity In T-Cell Acute Lymphoblastic Leukemia (T-ALL) Blood. 116: 12-12. DOI: 10.1182/Blood.V116.21.12.12  0.478
2009 Aparicio S, Eaves CJ. p53: a new kingpin in the stem cell arena. Cell. 138: 1060-2. PMID 19766559 DOI: 10.1016/J.Cell.2009.09.004  0.443
2009 Martignani E, Eirew P, Eaves C, Baratta M. Functional identification of bovine mammary epithelial stem/progenitor cells Veterinary Research Communications. 33: 101-103. PMID 19578962 DOI: 10.1007/S11259-009-9254-Z  0.523
2009 Sloma I, Eaves CJ. TEL me all. Cell Stem Cell. 5: 5-6. PMID 19570506 DOI: 10.1016/J.Stem.2009.06.011  0.419
2009 Lu M, Kardel MD, O'Connor MD, Eaves CJ. Enhanced generation of hematopoietic cells from human hepatocarcinoma cell-stimulated human embryonic and induced pluripotent stem cells. Experimental Hematology. 37: 924-36. PMID 19481135 DOI: 10.1016/J.Exphem.2009.05.007  0.586
2009 Vercauteren SM, Bashashati A, Wu D, Brinkman RR, Eaves C, Eaves A, Karsan A. Reduction in multi-lineage and erythroid progenitors distinguishes myelodysplastic syndromes from non-malignant cytopenias. Leukemia Research. 33: 1636-42. PMID 19414193 DOI: 10.1016/J.Leukres.2009.03.019  0.348
2009 Kent DG, Copley MR, Benz C, Wöhrer S, Dykstra BJ, Ma E, Cheyne J, Zhao Y, Bowie MB, Zhao Y, Gasparetto M, Delaney A, Smith C, Marra M, Eaves CJ. Prospective isolation and molecular characterization of hematopoietic stem cells with durable self-renewal potential. Blood. 113: 6342-50. PMID 19377048 DOI: 10.1182/Blood-2008-12-192054  0.503
2009 Hills M, Lücke K, Chavez EA, Eaves CJ, Lansdorp PM. Probing the mitotic history and developmental stage of hematopoietic cells using single telomere length analysis (STELA). Blood. 113: 5765-75. PMID 19359409 DOI: 10.1182/Blood-2009-01-198374  0.575
2009 Finkbeiner MR, Astanehe A, To K, Fotovati A, Davies AH, Zhao Y, Jiang H, Stratford AL, Shadeo A, Boccaccio C, Comoglio P, Mertens PR, Eirew P, Raouf A, Eaves CJ, et al. Profiling YB-1 target genes uncovers a new mechanism for MET receptor regulation in normal and malignant human mammary cells. Oncogene. 28: 1421-31. PMID 19151767 DOI: 10.1038/Onc.2008.485  0.418
2009 Zeng F, Chen M, Gong Z, Baldwin DA, Qian H, Yan J, Wang J, Chen X, Xiao YP, Chalandon Y, Ren Z, Eaves AC, Eaves CJ, Huang S, Jiang X. Multi-Tissue, Long-Term Engraftment and Expansion of BCR-ABL-transduced Human Lin-CD34+ Cord Blood Cells in a Large Animal Model. Blood. 114: 3265-3265. DOI: 10.1182/Blood.V114.22.3265.3265  0.575
2009 Cheung AM, Eaves CJ. Human Cord Blood Cells with Rapid In Vivo Platelet Regenerating Activity in NOD/SCID-IL-2Rγc-/- Mice Show Variable Aldehyde Dehydrogenase Activity. Blood. 114: 2429-2429. DOI: 10.1182/Blood.V114.22.2429.2429  0.474
2009 Eirew P, Yu M, Brinkman R, Eaves CJ. Reply to 'Reassessing the human mammary stem cell concept by modeling limiting dilution transplantation assays' Nature Medicine. 15: 604-605. DOI: 10.1038/nm0609-604  0.404
2008 Eaves CJ. Cancer stem cells: Here, there, everywhere? Nature. 456: 581-2. PMID 19052611 DOI: 10.1038/456581A  0.551
2008 Eirew P, Stingl J, Raouf A, Turashvili G, Aparicio S, Emerman JT, Eaves CJ. A method for quantifying normal human mammary epithelial stem cells with in vivo regenerative ability. Nature Medicine. 14: 1384-9. PMID 19029987 DOI: 10.1038/Nm.1791  0.58
2008 Lee C, Dhillon J, Wang MY, Gao Y, Hu K, Park E, Astanehe A, Hung MC, Eirew P, Eaves CJ, Dunn SE. Targeting YB-1 in HER-2 overexpressing breast cancer cells induces apoptosis via the mTOR/STAT3 pathway and suppresses tumor growth in mice. Cancer Research. 68: 8661-6. PMID 18974106 DOI: 10.1158/0008-5472.Can-08-1082  0.351
2008 Salvagiotto G, Zhao Y, Vodyanik M, Ruotti V, Stewart R, Marra M, Thomson J, Eaves C, Slukvin I. Molecular profiling reveals similarities and differences between primitive subsets of hematopoietic cells generated in vitro from human embryonic stem cells and in vivo during embryogenesis Experimental Hematology. 36: 1377-1389. PMID 18922365 DOI: 10.1016/J.Exphem.2008.06.015  0.589
2008 Cramer K, Nieborowska-Skorska M, Koptyra M, Slupianek A, Penserga ET, Eaves CJ, Aulitzky W, Skorski T. BCR/ABL and other kinases from chronic myeloproliferative disorders stimulate single-strand annealing, an unfaithful DNA double-strand break repair. Cancer Research. 68: 6884-8. PMID 18757400 DOI: 10.1158/0008-5472.Can-08-1101  0.402
2008 Starczynowski DT, Vercauteren S, Telenius A, Sung S, Tohyama K, Brooks-Wilson A, Spinelli JJ, Eaves CJ, Eaves AC, Horsman DE, Lam WL, Karsan A. High-resolution whole genome tiling path array CGH analysis of CD34+ cells from patients with low-risk myelodysplastic syndromes reveals cryptic copy number alterations and predicts overall and leukemia-free survival. Blood. 112: 3412-24. PMID 18663149 DOI: 10.1182/Blood-2007-11-122028  0.312
2008 Bañuelos CA, Banáth JP, MacPhail SH, Zhao J, Eaves CJ, O'Connor MD, Lansdorp PM, Olive PL. Mouse but not human embryonic stem cells are deficient in rejoining of ionizing radiation-induced DNA double-strand breaks Dna Repair. 7: 1471-1483. PMID 18602349 DOI: 10.1016/J.Dnarep.2008.05.005  0.438
2008 Raouf A, Zhao Y, To K, Stingl J, Delaney A, Barbara M, Iscove N, Jones S, McKinney S, Emerman J, Aparicio S, Marra M, Eaves C. Transcriptome analysis of the normal human mammary cell commitment and differentiation process. Cell Stem Cell. 3: 109-18. PMID 18593563 DOI: 10.1016/J.Stem.2008.05.018  0.551
2008 Jiang X, Zhao Y, Forrest D, Smith C, Eaves A, Eaves C. Stem cell biomarkers in chronic myeloid leukemia. Disease Markers. 24: 201-16. PMID 18525114 DOI: 10.1155/2008/146871  0.536
2008 Lindeman GJ, Visvader JE, Smalley MJ, Eaves CJ. The future of mammary stem cell biology: the power of in vivo transplants. Breast Cancer Research : Bcr. 10: 402; author reply 40. PMID 18522763 DOI: 10.1186/Bcr1986  0.53
2008 Kent DG, Dykstra BJ, Cheyne J, Ma E, Eaves CJ. Steel factor coordinately regulates the molecular signature and biologic function of hematopoietic stem cells. Blood. 112: 560-7. PMID 18502833 DOI: 10.1182/Blood-2007-10-117820  0.548
2008 Miller CL, Dykstra B, Eaves CJ. Characterization of mouse hematopoietic stem and progenitor cells. Current Protocols in Immunology / Edited by John E. Coligan ... [Et Al.]. Unit 22B.2. PMID 18432636 DOI: 10.1002/0471142735.Im22B02S80  0.607
2008 Kent D, Copley M, Benz C, Dykstra B, Bowie M, Eaves C. Regulation of hematopoietic stem cells by the steel factor/KIT signaling pathway. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 14: 1926-30. PMID 18381929 DOI: 10.1158/1078-0432.Ccr-07-5134  0.482
2008 Goldman FD, Aubert G, Klingelhutz AJ, Hills M, Cooper SR, Hamilton WS, Schlueter AJ, Lambie K, Eaves CJ, Lansdorp PM. Characterization of primitive hematopoietic cells from patients with dyskeratosis congenita. Blood. 111: 4523-31. PMID 18310499 DOI: 10.1182/Blood-2007-10-120204  0.521
2008 Morin RD, O'Connor MD, Griffith M, Kuchenbauer F, Delaney A, Prabhu AL, Zhao Y, McDonald H, Zeng T, Hirst M, Eaves CJ, Marra MA. Application of massively parallel sequencing to microRNA profiling and discovery in human embryonic stem cells. Genome Research. 18: 610-21. PMID 18285502 DOI: 10.1101/Gr.7179508  0.324
2008 O'Connor MD, Kardel MD, Iosfina I, Youssef D, Lu M, Li MM, Vercauteren S, Nagy A, Eaves CJ. Alkaline phosphatase-positive colony formation is a sensitive, specific, and quantitative indicator of undifferentiated human embryonic stem cells. Stem Cells (Dayton, Ohio). 26: 1109-16. PMID 18276800 DOI: 10.1634/Stemcells.2007-0801  0.561
2008 Imren S, Heuser M, Chen L, Edin G, Eaves CJ, Humphries RK. MN1 Overexpression Promotes Proliferation and Self-Renewal of Primitive Normal Human Hematopoietic Cells Blood. 112: 681-681. DOI: 10.1182/Blood.V112.11.681.681  0.589
2008 Kent DG, Copley MR, Benz C, Dykstra BJ, Ma E, Cheyne J, Zhao Y, Gasparetto M, Delaney A, Smith C, Marra M, Eaves CJ. New Candidate Regulators of Hematopoietic Stem Cells Identified from Transcriptional Comparisons of Highly Purified Populations of Longterm Repopulating Cells with Markedly Different in Vivo Self-Renewal Activities Blood. 112: 2460-2460. DOI: 10.1182/Blood.V112.11.2460.2460  0.543
2008 Zhao Y, Delaney A, Raouf A, Raghuram K, Li HI, Schnerch A, Jiang X, Eaves AC, Marra MA, Eaves CJ. Differentially Expressed and Novel Transcripts in Highly Purified Chronic Phase CML Stem Cells Blood. 112: 193-193. DOI: 10.1182/Blood.V112.11.193.193  0.467
2008 Sloma I, Imren S, Zhao Y, Humphries K, Eaves CJ. A Novel Strategy for Expanding Primitive Leukemic Cells from Chronic Phase CML Patients by Forced Overexpression of a NUP98-HOXA10 Homeodomain Fusion Gene. Blood. 112: 1078-1078. DOI: 10.1182/Blood.V112.11.1078.1078  0.513
2008 Croizat H, Ponchio L, Nicolini FE, Nagel RL, Eaves CJ. Primitive haematopoietic progenitors in the blood of patients with sickle cell disease appear to be endogenously mobilized British Journal of Haematology. 111: 491-497. DOI: 10.1111/J.1365-2141.2000.02342.X  0.414
2008 Bakovic S, Ohta H, Imren S, Cavilla B, Eaves C, Humphries R. Ex vivo expansion of hematopoietic stem cells for use in nonmyeloablative transplantation Blood Cells, Molecules, and Diseases. 40: 269-270. DOI: 10.1016/j.bcmd.2007.10.048  0.394
2007 Kent D, Dykstra B, Eaves C. Isolation and assessment of long-term reconstituting hematopoietic stem cells from adult mouse bone marrow. Current Protocols in Stem Cell Biology. Unit 2A.4. PMID 18785176 DOI: 10.1002/9780470151808.Sc02A04S3  0.565
2007 Ungrin M, O'Connor M, Eaves C, Zandstra PW. Phenotypic analysis of human embryonic stem cells. Current Protocols in Stem Cell Biology. Unit 1B.3. PMID 18785161 DOI: 10.1002/9780470151808.Sc01B03S2  0.672
2007 Dykstra B, Kent D, Bowie M, McCaffrey L, Hamilton M, Lyons K, Lee SJ, Brinkman R, Eaves C. Long-term propagation of distinct hematopoietic differentiation programs in vivo. Cell Stem Cell. 1: 218-29. PMID 18371352 DOI: 10.1016/J.Stem.2007.05.015  0.536
2007 Christ O, Lucke K, Imren S, Leung K, Hamilton M, Eaves A, Smith C, Eaves C. Improved purification of hematopoietic stem cells based on their elevated aldehyde dehydrogenase activity. Haematologica. 92: 1165-1172. PMID 17666374 DOI: 10.3324/Haematol.11366  0.519
2007 Ohta H, Sekulovic S, Bakovic S, Eaves CJ, Pineault N, Gasparetto M, Smith C, Sauvageau G, Humphries RK. Near-maximal expansions of hematopoietic stem cells in culture using NUP98-HOX fusions. Experimental Hematology. 35: 817-30. PMID 17577930 DOI: 10.1016/J.Exphem.2007.02.012  0.53
2007 Hirst M, Delaney A, Rogers SA, Schnerch A, Persaud DR, O'Connor MD, Zeng T, Moksa M, Fichter K, Mah D, Go A, Morin RD, Baross A, Zhao Y, Khattra J, ... ... Eaves CJ, et al. LongSAGE profiling of nine human embryonic stem cell lines. Genome Biology. 8: R113. PMID 17570852 DOI: 10.1186/Gb-2007-8-6-R113  0.5
2007 Jiang X, Saw KM, Eaves A, Eaves C. Instability of BCR-ABL gene in primary and cultured chronic myeloid leukemia stem cells. Journal of the National Cancer Institute. 99: 680-93. PMID 17470736 DOI: 10.1093/Jnci/Djk150  0.475
2007 Zhao Y, Raouf A, Kent D, Khattra J, Delaney A, Schnerch A, Asano J, McDonald H, Chan C, Jones S, Marra MA, Eaves CJ. A modified polymerase chain reaction-long serial analysis of gene expression protocol identifies novel transcripts in human CD34+ bone marrow cells. Stem Cells (Dayton, Ohio). 25: 1681-9. PMID 17412892 DOI: 10.1634/Stemcells.2006-0794  0.533
2007 Jiang X, Smith C, Eaves A, Eaves C. The challenges of targeting chronic myeloid leukemia stem cells. Clinical Lymphoma & Myeloma. S71-80. PMID 17382016 DOI: 10.3816/Clm.2007.S.005  0.539
2007 Bowie MB, Kent DG, Dykstra B, McKnight KD, McCaffrey L, Hoodless PA, Eaves CJ. Identification of a new intrinsically timed developmental checkpoint that reprograms key hematopoietic stem cell properties. Proceedings of the National Academy of Sciences of the United States of America. 104: 5878-82. PMID 17379664 DOI: 10.1073/Pnas.0700460104  0.5
2007 Bowie MB, Kent DG, Copley MR, Eaves CJ. Steel factor responsiveness regulates the high self-renewal phenotype of fetal hematopoietic stem cells. Blood. 109: 5043-8. PMID 17327414 DOI: 10.1182/Blood-2006-08-037770  0.469
2007 Bowie MB, McKnight KD, Kent DG, McCaffrey L, Hoodless PA, Eaves CJ. Hematopoietic stem cells proliferate until after birth and show a reversible phase-specific engraftment defect. The Journal of Clinical Investigation. 116: 2808-16. PMID 17016561 DOI: 10.1172/Jci28310  0.489
2007 Aubert G, Goldman FD, Klingelhutz AJ, Hills M, Cooper SR, Hamilton WS, Schlueter A, Eaves CJ, Lansdorp PM. Loss of Primitive Hematopoietic Cells in Patients with Dyskeratosis Congenita. Blood. 110: LB3-LB3. DOI: 10.1182/Blood.V110.11.Lb3.Lb3  0.497
2007 Zhao Y, Delaney A, Marra MA, Jiang X, Eaves AC, Eaves CJ. Comparative Transcriptome Analysis of Different Subsets of CD34+ Normal and Chronic Myeloid Leukemia Cells Identifies Novel Perturbations in the CML Stem Cell Population. Blood. 110: 35-35. DOI: 10.1182/Blood.V110.11.35.35  0.589
2007 Jiang X, Forrest D, Nicolini F, Lambie K, Saw KM, Pang E, Vukovic R, Smith C, Eaves A, Eaves C. Properties of CD34+ CML Cells That Predict Clinical Response to Tyrosine Kinase Inhibitors. Blood. 110: 324-324. DOI: 10.1182/Blood.V110.11.324.324  0.468
2007 Starczynowski DT, Vercauteren S, Telenius A, Sung S, Tohyama K, Brooks-Wilson A, Spinelli JJ, Eaves CJ, Eaves AC, Horsman DE, Lam WL, Karsan A. High-Resolution CGH Analysis of CD34+ Cells from Lower-Risk Myelodysplastic Patients Reveals Cryptic Copy Number Alterations and Predicts Overall and Leukemia-Free Survival. Blood. 110: 2431-2431. DOI: 10.1182/Blood.V110.11.2431.2431  0.367
2007 Kent D, Zhao Y, Bowie M, Dykstra B, Cheyne J, Zhao Y, Delaney A, Hirst M, Marra M, Eaves CJ. Differences in the Transcriptomes of Highly Purified Fetal Liver and Adult Bone Marrow Hematopoietic Stem Cells Revealed by Long Serial Analysis of Gene Expression (LongSAGE) Blood. 110: 1277-1277. DOI: 10.1182/Blood.V110.11.1277.1277  0.482
2006 Glover CH, Marin M, Eaves CJ, Helgason CD, Piret JM, Bryan J. Meta-analysis of differentiating mouse embryonic stem cell gene expression kinetics reveals early change of a small gene set. Plos Computational Biology. 2: e158. PMID 17121458 DOI: 10.1371/Journal.Pcbi.0020158  0.685
2006 Clarke MF, Dick JE, Dirks PB, Eaves CJ, Jamieson CH, Jones DL, Visvader J, Weissman IL, Wahl GM. Cancer stem cells--perspectives on current status and future directions: AACR Workshop on cancer stem cells. Cancer Research. 66: 9339-44. PMID 16990346 DOI: 10.1158/0008-5472.Can-06-3126  0.453
2006 Stingl J, Raouf A, Eirew P, Eaves CJ. Deciphering the mammary epithelial cell hierarchy. Cell Cycle (Georgetown, Tex.). 5: 1519-22. PMID 16861925 DOI: 10.4161/Cc.5.14.2983  0.55
2006 Asselin-Labat ML, Shackleton M, Stingl J, Vaillant F, Forrest NC, Eaves CJ, Visvader JE, Lindeman GJ. Steroid hormone receptor status of mouse mammary stem cells. Journal of the National Cancer Institute. 98: 1011-4. PMID 16849684 DOI: 10.1093/Jnci/Djj267  0.4
2006 Fischer M, Schmidt M, Klingenberg S, Eaves CJ, von Kalle C, Glimm H. Short-term repopulating cells with myeloid potential in human mobilized peripheral blood do not have a side population (SP) phenotype. Blood. 108: 2121-3. PMID 16735598 DOI: 10.1182/Blood-2006-03-013599  0.523
2006 Dykstra B, Ramunas J, Kent D, McCaffrey L, Szumsky E, Kelly L, Farn K, Blaylock A, Eaves C, Jervis E. High-resolution video monitoring of hematopoietic stem cells cultured in single-cell arrays identifies new features of self-renewal. Proceedings of the National Academy of Sciences of the United States of America. 103: 8185-90. PMID 16702542 DOI: 10.1073/Pnas.0602548103  0.547
2006 Chung YJ, Park BB, Kang YJ, Kim TM, Eaves CJ, Oh IH. Unique effects of Stat3 on the early phase of hematopoietic stem cell regeneration. Blood. 108: 1208-15. PMID 16614239 DOI: 10.1182/Blood-2006-01-010199  0.515
2006 Yang H, Eaves C, de Lima M, Lee MS, Champlin RE, McMannis JD, Robinson SN, Niu T, Decker WK, Xing D, Ng J, Li S, Yao X, Eaves AC, Jones R, et al. A novel triple purge strategy for eliminating chronic myelogenous leukemia (CML) cells from autografts. Bone Marrow Transplantation. 37: 575-82. PMID 16435011 DOI: 10.1038/Sj.Bmt.1705284  0.551
2006 Jørgensen HG, Copland M, Allan EK, Jiang X, Eaves A, Eaves C, Holyoake TL. Intermittent exposure of primitive quiescent chronic myeloid leukemia cells to granulocyte-colony stimulating factor in vitro promotes their elimination by imatinib mesylate. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 12: 626-33. PMID 16428509 DOI: 10.1158/1078-0432.Ccr-05-0429  0.409
2006 Stingl J, Eirew P, Ricketson I, Shackleton M, Vaillant F, Choi D, Li HI, Eaves CJ. Purification and unique properties of mammary epithelial stem cells. Nature. 439: 993-7. PMID 16395311 DOI: 10.1038/Nature04496  0.579
2006 Jiang X, Zhao Y, Smith C, Gasparetto M, Saw KM, Turhan A, Eaves A, Eaves C. Chronic Myeloid Leukemia Stem Cells Possess Unique Properties That Predict Intrinsic and Acquired Resistance to Imatinib Mesylate. Blood. 108: 752-752. DOI: 10.1182/BLOOD.V108.11.752.752  0.406
2006 Kent DG, Dykstra B, Eaves CJ. Rapid and Irreversible Alteration of the Ability of Hematopoietic Stem Cells To Execute Both Symmetric and Asymmetric Self-Renewal Divisions by Exposure to Reduced Steel Factor Concentrations with No Effect on Their Survival or Mitogenesis. Blood. 108: 684-684. DOI: 10.1182/Blood.V108.11.684.684  0.547
2006 Bakovic S, Rosten PM, Eaves CJ, Humphries RK. Therapeutic Effect of HOXB4-Expanded Stem Cells in Mice with Beta Thalassemia Given a Non-Myeloablative Conditioning Regimen. Blood. 108: 341-341. DOI: 10.1182/Blood.V108.11.341.341  0.508
2006 Dykstra B, Kent D, Hamilton M, Kristiansen M, Lyons K, McCaffrey L, Russell S, Eaves CJ. Unexpected and Sustained Symmetry in the Repopulation Programs Displayed by Clonally Amplified Hematopoietic Stem Cells. Blood. 108: 1651-1651. DOI: 10.1182/Blood.V108.11.1651.1651  0.506
2006 Imren S, Sauvageau G, Eaves CJ, Humphries RK. A NUP98-HOX Fusion Gene Containing the Homeodomain of HOXA10 Promotes Significant Expansion of Primitive Human Hematopoietic Cells in Extended Cultures. Blood. 108: 1351-1351. DOI: 10.1182/Blood.V108.11.1351.1351  0.451
2005 Sieburg HB, Cho RH, Dykstra B, Uchida N, Eaves CJ, Muller-Sieburg CE. The hematopoietic stem compartment consists of a limited number of discrete stem cell subsets. Blood. 107: 2311-6. PMID 16291588 DOI: 10.1182/Blood-2005-07-2970  0.498
2005 Raouf A, Brown L, Vrcelj N, To K, Kwok W, Huntsman D, Eaves CJ. Genomic instability of human mammary epithelial cells overexpressing a truncated form of EMSY. Journal of the National Cancer Institute. 97: 1302-6. PMID 16145051 DOI: 10.1093/Jnci/Dji254  0.405
2005 Jørgensen HG, Allan EK, Graham SM, Godden JL, Richmond L, Elliott MA, Mountford JC, Eaves CJ, Holyoake TL. Lonafarnib reduces the resistance of primitive quiescent CML cells to imatinib mesylate in vitro. Leukemia. 19: 1184-91. PMID 15889158 DOI: 10.1038/sj.leu.2403785  0.393
2005 Stingl J, Raouf A, Emerman JT, Eaves CJ. Epithelial progenitors in the normal human mammary gland. Journal of Mammary Gland Biology and Neoplasia. 10: 49-59. PMID 15886886 DOI: 10.1007/S10911-005-2540-7  0.582
2005 Glimm H, Schmidt M, Fischer M, Schwarzwaelder K, Wissler M, Klingenberg S, Prinz C, Waller CF, Lange W, Eaves CJ, von Kalle C. Efficient marking of human cells with rapid but transient repopulating activity in autografted recipients. Blood. 106: 893-8. PMID 15845903 DOI: 10.1182/Blood-2004-07-2859  0.559
2005 Eisterer W, Jiang X, Christ O, Glimm H, Lee KH, Pang E, Lambie K, Shaw G, Holyoake TL, Petzer AL, Auewarakul C, Barnett MJ, Eaves CJ, Eaves AC. Different subsets of primary chronic myeloid leukemia stem cells engraft immunodeficient mice and produce a model of the human disease Leukemia. 19: 435-441. PMID 15674418 DOI: 10.1038/Sj.Leu.2403649  0.594
2005 Glimm H, Schmidt M, Fischer M, Klingenberg S, Lange W, Waller CF, Eaves CJ, von Kalle C. Evidence of similar effects of short-term culture on the initial repopulating activity of mobilized peripheral blood transplants assessed in NOD/SCID-beta2microglobulin(null) mice and in autografted patients. Experimental Hematology. 33: 20-5. PMID 15661394 DOI: 10.1016/J.Exphem.2004.10.003  0.459
2005 Eaves CJ. SDF-1 tells stem cells to mind their P's and Z's. The Journal of Clinical Investigation. 115: 27-9. PMID 15630439 DOI: 10.1172/Jci24013  0.519
2005 Stingl J, Emerman JT, Eaves CJ. Enzymatic dissociation and culture of normal human mammary tissue to detect progenitor activity. Methods in Molecular Biology (Clifton, N.J.). 290: 249-63. PMID 15361667 DOI: 10.1385/1-59259-838-2:249  0.499
2005 Dykstra B, Ramunas J, Kent D, McCaffrey L, Szumsky E, Kelly L, Farn K, Eaves C, Jervis E. High Resolution Time-Lapse Monitoring of Individual Hematopoietic Stem Cells Reveals New Biomarkers of Self-Renewal. Blood. 106: 795-795. DOI: 10.1182/Blood.V106.11.795.795  0.545
2005 Jiang X, Saw KM, Eaves A, Eaves C. Leukemic Stem Cells of Chronic Phase CML Patients Possess Uniquely Elevated BCR-ABL Kinase Activity and Acquire Spontaneous BCR-ABL Kinase Domain Mutations at a High Frequency. Blood. 106: 438-438. DOI: 10.1182/Blood.V106.11.438.438  0.437
2005 Dykstra B, Kent D, McCaffrey L, Lyons K, Kristiansen M, Hamilton M, Eaves C. New Fine Structure within the Adult Hematopoietic Stem Cell Compartment Revealed by Longterm Analysis of Mice Repopulated with Single Cells or Their In Vitro Generated Clonal Progeny. Blood. 106: 1720-1720. DOI: 10.1182/Blood.V106.11.1720.1720  0.494
2004 Chaudhry MA, Bowen BD, Eaves CJ, Piret JM. Empirical models of the proliferative response of cytokine-dependent hematopoietic cell lines. Biotechnology and Bioengineering. 88: 348-58. PMID 15486941 DOI: 10.1002/Bit.20249  0.63
2004 Imren S, Fabry ME, Westerman KA, Pawliuk R, Tang P, Rosten PM, Nagel RL, Leboulch P, Eaves CJ, Humphries RK. High-level beta-globin expression and preferred intragenic integration after lentiviral transduction of human cord blood stem cells. The Journal of Clinical Investigation. 114: 953-62. PMID 15467834 DOI: 10.1172/Jci21838  0.525
2004 Eaves C. Hematopoietic stem cells get closer to the bone Nature Medicine. 10: 1042-1044. PMID 15459701 DOI: 10.1038/Nm1004-1042  0.518
2004 Shier LR, Schultz KR, Imren S, Regan J, Issekutz A, Sadek I, Gilman A, Luo Z, Panzarella T, Eaves CJ, Couban S. Differential effects of granulocyte colony-stimulating factor on marrow- and blood-derived hematopoietic and immune cell populations in healthy human donors. Biology of Blood and Marrow Transplantation : Journal of the American Society For Blood and Marrow Transplantation. 10: 624-34. PMID 15319774 DOI: 10.1016/J.Bbmt.2004.05.009  0.468
2004 Oh IH, Fabry ME, Humphries RK, Pawliuk R, Leboulch P, Hoffman R, Nagel RL, Eaves C. Expression of an anti-sickling beta-globin in human erythroblasts derived from retrovirally transduced primitive normal and sickle cell disease hematopoietic cells. Experimental Hematology. 32: 461-9. PMID 15145214 DOI: 10.1016/J.Exphem.2004.02.001  0.495
2004 Chalandon Y, Jiang X, Loutet S, Eaves AC, Eaves CJ. Growth autonomy and lineage switching in BCR-ABL-transduced human cord blood cells depend on different functional domains of BCR-ABL. Leukemia. 18: 1006-12. PMID 15014528 DOI: 10.1038/sj.leu.2403335  0.432
2004 Uchida N, Dykstra B, Lyons K, Leung F, Kristiansen M, Eaves C. ABC transporter activities of murine hematopoietic stem cells vary according to their developmental and activation status. Blood. 103: 4487-95. PMID 14988157 DOI: 10.1182/Blood-2003-11-3989  0.521
2004 Thanopoulou E, Cashman J, Kakagianne T, Eaves A, Zoumbos N, Eaves C. Engraftment of NOD/SCID-β2 microglobulin null mice with multilineage neoplastic cells from patients with myelodysplastic syndrome Blood. 103: 4285-4293. PMID 14962905 DOI: 10.1182/Blood-2003-09-3192  0.54
2004 Jiang X, Zhao Y, Chan WY, Vercauteren S, Pang E, Kennedy S, Nicolini F, Eaves A, Eaves C. Deregulated expression in Ph+ human leukemias of AHI-1, a gene activated by insertional mutagenesis in mouse models of leukemia. Blood. 103: 3897-904. PMID 14751929 DOI: 10.1182/Blood-2003-11-4026  0.512
2004 Nicolini FE, Cashman JD, Hogge DE, Humphries RK, Eaves CJ. NOD/SCID mice engineered to express human IL-3, GM-CSF and Steel factor constitutively mobilize engrafted human progenitors and compromise human stem cell regeneration. Leukemia. 18: 341-7. PMID 14628073 DOI: 10.1038/Sj.Leu.2403222  0.513
2004 Jiang X, Zhao Y, Chan WY, Pang E, Eaves A, Eaves C. Leukemic Stem Cells of Chronic Phase CML Patients Consistently Display Very High BCR-ABL Transcript Levels and Reduced Responsiveness to Imatinib Mesylate in Addition to Generating a Rare Subset That Produce Imatinib Mesylate-Resistant Differentiated Progeny. Blood. 104: 711-711. DOI: 10.1182/Blood.V104.11.711.711  0.588
2004 Christ O, Smith C, Leung K, Hamilton M, Eaves CJ. Identification of a New Population of Human Cord Blood Cells with Lymphoid-Restricted Reconstituting Potential in Sublethally Irradiated Immunodeficient Mice. Blood. 104: 3213-3213. DOI: 10.1182/Blood.V104.11.3213.3213  0.568
2004 Christ O, Eisterer W, Jiang X, Pang E, Leung K, Smith C, Eaves AC, Eaves CJ. Transplantation of Immunodeficient Mice with Chronic Myeloid Leukemia (CML) Cells from Chronic Phase Patients Reveals a Hierarchy of CD34+ Aldehyde Dehydrogenase-Positive Cells with Short- and Long-Term Repopulating Activity and Transient Responsiveness to Imatinib Mesylate in Vivo. Blood. 104: 2960-2960. DOI: 10.1182/Blood.V104.11.2960.2960  0.554
2004 Fischer M, Schmidt M, Klingenberg S, Eaves C, Kalle Cv, Glimm H. Most of the Short Term Repopulating Cells in Human Mobilized Peripheral Blood Do Not Have a Side Population (SP) Phenotype. Blood. 104: 2867-2867. DOI: 10.1182/Blood.V104.11.2867.2867  0.546
2004 Yang H, Eaves C, de Lima M, Lee M, Champlin R, McMannis J, Robinson S, Niu T, Decker W, Xing D, Thomas M, Ng J, Li S, Eaves A, Jones R, et al. A Novel Triple Purge Strategy for Eliminating Chronic Myelogenous Leukemia (CML) Cells from Autografts. Blood. 104: 152-152. DOI: 10.1182/Blood.V104.11.152.152  0.546
2004 Dykstra B, Uchida N, Hamilton M, Kristiansen M, Lyons K, Eaves CJ. Unexpectedly High Self-Renewal Capacity Demonstrable by Serial Transplantation Is a Property of a Subset of Normal Adult Mouse Hematopoietic Stem Cells. Blood. 104: 1189-1189. DOI: 10.1182/Blood.V104.11.1189.1189  0.507
2004 Imren S, Fabry ME, Westerman KA, Pawliuk R, Tang P, Rosten PM, Nagel RL, Leboulch P, Eaves CJ, Humphries RK. High-level β-globin expression and preferred intragenic integration after lentiviral transduction of human cord blood stem cells Journal of Clinical Investigation. 114: 953-962. DOI: 10.1172/JCI200421838  0.322
2003 Uchida N, Dykstra B, Lyons KJ, Leung FY, Eaves CJ. Different in vivo repopulating activities of purified hematopoietic stem cells before and after being stimulated to divide in vitro with the same kinetics. Experimental Hematology. 31: 1338-47. PMID 14662343 DOI: 10.1016/J.Exphem.2003.09.001  0.529
2003 Maeda M, Uchida N, Eaves CJ, Takei F. Slow receptor acquisition by NK cells regenerated in vivo from transplanted fetal liver or adult bone marrow stem cells. Experimental Hematology. 31: 1015-8. PMID 14585363  0.435
2003 Jiang X, Stuible M, Chalandon Y, Li A, Chan WY, Eisterer W, Krystal G, Eaves A, Eaves C. Evidence for a positive role of SHIP in the BCR-ABL-mediated transformation of primitive murine hematopoietic cells and in human chronic myeloid leukemia. Blood. 102: 2976-84. PMID 12829595 DOI: 10.1182/Blood-2003-05-1550  0.568
2003 Eaves C, Jiang X, Eisterer W, Chalandon Y, Porada G, Zanjani E, Eaves A. New models to investigate mechanisms of disease genesis from primitive BCR-ABL(+) hematopoietic cells. Annals of the New York Academy of Sciences. 996: 1-9. PMID 12799276 DOI: 10.1111/J.1749-6632.2003.Tb03226.X  0.53
2003 Eaves CJ. Manipulating hematopoietic stem cell amplification with Wnt. Nature Immunology. 4: 511-2. PMID 12774072 DOI: 10.1038/Ni0603-511  0.482
2003 Szilvassy SJ, Ragland PL, Miller CL, Eaves CJ. The marrow homing efficiency of murine hematopoietic stem cells remains constant during ontogeny. Experimental Hematology. 31: 331-8. PMID 12691921 DOI: 10.1016/S0301-472X(03)00005-5  0.502
2003 Feuring-Buske M, Gerhard B, Cashman J, Humphries RK, Eaves CJ, Hogge DE. Improved engraftment of human acute myeloid leukemia progenitor cells in beta 2-microglobulin-deficient NOD/SCID mice and in NOD/SCID mice transgenic for human growth factors. Leukemia. 17: 760-3. PMID 12682634 DOI: 10.1038/sj.leu.2402882  0.31
2003 Cashman J, Dykstra B, Clark-Lewis I, Eaves A, Eaves C. Changes in the proliferative activity of human hematopoietic stem cells in NOD/SCID mice and enhancement of their transplantability after in vivo treatment with cell cycle inhibitors. The Journal of Experimental Medicine. 196: 1141-9. PMID 12417625 DOI: 10.1084/Jem.20010916  0.554
2003 Holyoake TL, Horrocks C, Thomas T, Eaves CJ, Eaves AC. Cell separation improves the sensitivity of detecting rare human normal and leukemic hematopoietic cells in vivo in NOD/SCID mice. Cytotherapy. 2: 411-21. PMID 12044221 DOI: 10.1080/146532400539350  0.524
2003 Maeda M, Uchida N, Eaves CJ, Takei F. Slow receptor acquisition by NK cells regenerated in vivo from transplanted fetal liver or adult bone marrow stem cells. Experimental Hematology. 31: 1015-1018. DOI: 10.1016/J.Exphem.2003.08.017  0.522
2002 Miller CL, Audet J, Eaves CJ. Ex vivo expansion of human and murine hematopoietic stem cells. Methods in Molecular Medicine. 63: 189-208. PMID 21437809 DOI: 10.1385/1-59259-140-X:189  0.511
2002 Szilvassy SJ, Nicolini FE, Eaves CJ, Miller CL. Quantitation of murine and human hematopoietic stem cells by limiting-dilution analysis in competitively repopulated hosts. Methods in Molecular Medicine. 63: 167-87. PMID 21437808 DOI: 10.1385/1-59259-140-X:167  0.502
2002 Miller CL, Eaves CJ. Long-term culture-initiating cell assays for human and murine cells. Methods in Molecular Medicine. 63: 123-41. PMID 21437804 DOI: 10.1385/1-59259-140-X:123  0.475
2002 Richmond LJ, Alcorn MJ, Pearson C, Cameron G, Thomas T, Eaves CJ, Eaves AC, Holyoake TL. CML leukapheresis products can be enriched for CD34+ cells and simultaneously depleted of CD15+ cells using a simple Ab cocktail. Cytotherapy. 4: 407-13. PMID 12473207 DOI: 10.1080/146532402320775991  0.379
2002 Jiang X, Ng E, Yip C, Eisterer W, Chalandon Y, Stuible M, Eaves A, Eaves CJ. Primitive interleukin 3 null hematopoietic cells transduced with BCR-ABL show accelerated loss after culture of factor-independence in vitro and leukemogenic activity in vivo. Blood. 100: 3731-40. PMID 12393460 DOI: 10.1182/Blood-2002-05-1324  0.473
2002 Imren S, Payen E, Westerman KA, Pawliuk R, Fabry ME, Eaves CJ, Cavilla B, Wadsworth LD, Beuzard Y, Bouhassira EE, Russell R, London IM, Nagel RL, Leboulch P, Humphries RK. Permanent and panerythroid correction of murine beta thalassemia by multiple lentiviral integration in hematopoietic stem cells. Proceedings of the National Academy of Sciences of the United States of America. 99: 14380-5. PMID 12391330 DOI: 10.1073/Pnas.212507099  0.446
2002 Audet J, Miller CL, Eaves CJ, Piret JM. Common and distinct features of cytokine effects on hematopoietic stem and progenitor cells revealed by dose-response surface analysis. Biotechnology and Bioengineering. 80: 393-404. PMID 12325147 DOI: 10.1002/Bit.10399  0.703
2002 Miller CL, Imren S, Antonchuk J, Kalberer C, Fabry ME, Nagel RL, Humphries RK, Eaves CJ. Feasibility of using autologous transplantation to evaluate hematopoietic stem cell-based gene therapy strategies in transgenic mouse models of human disease. Molecular Therapy : the Journal of the American Society of Gene Therapy. 6: 422-8. PMID 12231180 DOI: 10.1006/Mthe.2002.0679  0.491
2002 Uchida N, Leung FY, Eaves CJ. Liver and marrow of adult mdr-1a/1b(-/-) mice show normal generation, function, and multi-tissue trafficking of primitive hematopoietic cells. Experimental Hematology. 30: 862-9. PMID 12160837 DOI: 10.1016/S0301-472X(02)00879-2  0.468
2002 Nicolini FE, Imren S, Oh IH, Humphries RK, Leboulch P, Fabry ME, Nagel RL, Eaves CJ. Expression of a human beta-globin transgene in erythroid cells derived from retrovirally transduced transplantable human fetal liver and cord blood cells. Blood. 100: 1257-64. PMID 12149206 DOI: 10.1182/Blood-2002-02-0599  0.562
2002 Buske C, Feuring-Buske M, Abramovich C, Spiekermann K, Eaves CJ, Coulombel L, Sauvageau G, Hogge DE, Humphries RK. Deregulated expression of HOXB4 enhances the primitive growth activity of human hematopoietic cells. Blood. 100: 862-8. PMID 12130496 DOI: 10.1182/Blood-2002-01-0220  0.593
2002 Oh IH, Eaves CJ. Overexpression of a dominant negative form of STAT3 selectively impairs hematopoietic stem cell activity. Oncogene. 21: 4778-87. PMID 12101416 DOI: 10.1038/Sj.Onc.1205592  0.545
2002 Glimm H, Tang P, Clark-Lewis I, Kalle Cv, Eaves C. Ex vivo treatment of proliferating human cord blood stem cells with stroma-derived factor-1 enhances their ability to engraft NOD/SCID mice. Blood. 99: 3454-3457. PMID 11964317 DOI: 10.1182/Blood.V99.9.3454  0.491
2002 Chalandon Y, Jiang X, Hazlewood G, Loutet S, Conneally E, Eaves A, Eaves C. Modulation of p210(BCR-ABL) activity in transduced primary human hematopoietic cells controls lineage programming. Blood. 99: 3197-204. PMID 11964283 DOI: 10.1182/Blood.V99.9.3197  0.601
2002 Holyoake T, Jiang X, Drummond M, Eaves A, Eaves C. Elucidating critical mechanisms of deregulated stem cell turnover in the chronic phase of chronic myeloid leukemia Leukemia. 16: 549-558. PMID 11960331 DOI: 10.1038/Sj.Leu.2402444  0.547
2002 Eisterer W, Jiang X, Bachelot T, Pawliuk R, Abramovich C, Leboulch P, Hogge D, Eaves C. Unfulfilled promise of endostatin in a gene therapy-xenotransplant model of human acute lymphocytic leukemia. Molecular Therapy : the Journal of the American Society of Gene Therapy. 5: 352-9. PMID 11945061 DOI: 10.1006/Mthe.2002.0573  0.46
2002 Cashman J, Clark-Lewis I, Eaves A, Eaves C. Stromal-derived factor 1 inhibits the cycling of very primitive human hematopoietic cells in vitro and in NOD/SCID mice. Blood. 99: 792-9. PMID 11806978 DOI: 10.1182/Blood.V99.3.792  0.569
2002 Stingl J, Eaves CJ, Zandieh I, Emerman JT. Characterization of bipotent mammary epithelial progenitor cells in normal adult human breast tissue. Breast Cancer Research and Treatment. 67: 93-109. PMID 11519870 DOI: 10.1023/A:1010615124301  0.545
2002 Eaves C. Stem Cells and the Future of Regenerative Medicine Nature Medicine. 8: 326-326. DOI: 10.1038/Nm0402-326  0.511
2002 Eaves A, Cashman J, Eaves C. Regulators of human stem cell proliferation and engraftment International Journal of Hematology. 76: 159-159. DOI: 10.1007/Bf03165236  0.601
2002 Chung Y, Kim T, Eaves C, Oh I. Role of STAT3 for hematopoietic stem cells International Journal of Hematology. 76: 152-152. DOI: 10.1007/Bf03165231  0.545
2001 Pawliuk R, Westerman KA, Fabry ME, Payen E, Tighe R, Bouhassira EE, Acharya SA, Ellis J, London IM, Eaves CJ, Humphries RK, Beuzard Y, Nagel RL, Leboulch P. Correction of sickle cell disease in transgenic mouse models by gene therapy. Science (New York, N.Y.). 294: 2368-71. PMID 11743206 DOI: 10.1126/Science.1065806  0.492
2001 Uchida N, Fujisaki T, Eaves AC, Eaves CJ. Transplantable hematopoietic stem cells in human fetal liver have a CD34(+) side population (SP)phenotype. The Journal of Clinical Investigation. 108: 1071-7. PMID 11581308 DOI: 10.1172/Jci13297  0.589
2001 Eaves C, Glimm H, Eisterer W, Audet J, Maguer-Satta V, Piret J. Characterization of human hematopoietic cells with short-lived in vivo repopulating activity. Annals of the New York Academy of Sciences. 938: 63-70; discussion 70. PMID 11458527 DOI: 10.1111/J.1749-6632.2001.Tb03575.X  0.565
2001 Brümmendorf TH, Rufer N, Holyoake TL, Maciejewski J, Barnett MJ, Eaves CJ, Eaves AC, Young N, Lansdorp PM. Telomere length dynamics in normal individuals and in patients with hematopoietic stem cell-associated disorders. Annals of the New York Academy of Sciences. 938: 293-303; discussion . PMID 11458518 DOI: 10.1111/J.1749-6632.2001.Tb03598.X  0.398
2001 Buske C, Feuring-Buske M, Antonchuk J, Rosten P, Hogge DE, Eaves CJ, Humphries RK. Overexpression of HOXA10 perturbs human lymphomyelopoiesis in vitro and in vivo Blood. 97: 2286-2292. PMID 11290589 DOI: 10.1182/Blood.V97.8.2286  0.516
2001 Audet J, Miller CL, Rose-John S, Piret JM, Eaves CJ. Distinct role of gp130 activation in promoting self-renewal divisions by mitogenically stimulated murine hematopoietic stem cells. Proceedings of the National Academy of Sciences of the United States of America. 98: 1757-62. PMID 11172024 DOI: 10.1073/Pnas.98.4.1757  0.716
2001 Glimm H, Eisterer W, Lee K, Cashman J, Holyoake TL, Nicolini F, Shultz LD, von Kalle C, Eaves CJ. Previously undetected human hematopoietic cell populations with short-term repopulating activity selectively engraft NOD/SCID-beta2 microglobulin-null mice. The Journal of Clinical Investigation. 107: 199-206. PMID 11160136 DOI: 10.1172/Jci11519  0.544
2001 Holyoake TL, Jiang X, Jorgensen HG, Graham S, Alcorn MJ, Laird C, Eaves AC, Eaves CJ. Primitive quiescent leukemic cells from patients with chronic myeloid leukemia spontaneously initiate factor-independent growth in vitro in association with up-regulation of expression of interleukin-3. Blood. 97: 720-8. PMID 11157490 DOI: 10.1182/Blood.V97.3.720  0.511
2001 Croizat H, Ponchio L, Nicolini FE, Nagel RL, Eaves CJ. Primitive haematopoietic progenitors in the blood of patients with sickle cell disease appear to be endogenously mobilized. British Journal of Haematology. 111: 491-7. PMID 11122089 DOI: 10.1046/J.1365-2141.2000.02342.X  0.494
2001 Audet J, Eaves CJ, Piret JM. Modeling of Hematopoietic Stem Cell Response to Cytokines Ifac Proceedings Volumes. 34: 65-68. DOI: 10.1016/S1474-6670(17)34196-4  0.674
2001 Buske C, Feuring-Buske M, Hogge D, Eaves C, Humphries R. Constitutive expression of the homeobox transcription factor HOXB4 amplifies human primitive hematopoietic progenitor cells in vitro and in vivo European Journal of Cancer. 37: S87. DOI: 10.1016/S0959-8049(01)80456-1  0.498
2000 Oostendorp RAJ, Ghaffari S, Eaves CJ. Kinetics of in vivo homing and recruitment into cycle of hematopoietic cells are organ-specific but CD44-independent. Bone Marrow Transplantation. 26: 559-566. PMID 11019847 DOI: 10.1038/Sj.Bmt.1702536  0.523
2000 Eaves C, Zandstra P, Conneally E, Miller C, Cashman J, Petzer A, Piret J. Changes in the cytokine regulation of stem cell self-renewal during ontogeny. Stem Cells (Dayton, Ohio). 177-84. PMID 11012160 DOI: 10.1002/Stem.5530160821  0.827
2000 Eaves AC, Barnett MJ, Ponchio L, Cashman JD, Petzer AL, Eaves CJ. Differences between normal and CML stem cells: potential targets for clinical exploitation. Stem Cells (Dayton, Ohio). 77-83; discussion 89. PMID 11012149 DOI: 10.1002/Stem.5530160809  0.581
2000 Zandstra PW, Lauffenburger DA, Eaves CJ. A ligand-receptor signaling threshold model of stem cell differentiation control: A biologically conserved mechanism applicable to hematopoiesis Blood. 96: 1215-1222. PMID 10942360 DOI: 10.1182/Blood.V96.4.1215.H8001215_1215_1222  0.724
2000 Jiang X, Fujisaki T, Nicolini F, Berger M, Holyoake T, Eisterer W, Eaves C, Eaves A. Autonomous multi-lineage differentiation in vitro of primitive CD34+ cells from patients with chronic myeloid leukemia. Leukemia. 14: 1112-1121. PMID 10865977 DOI: 10.1038/Sj.Leu.2401752  0.505
2000 Kalberer CP, Pawliuk R, Imren S, Bachelot T, Takekoshi KJ, Fabry M, Eaves CJ, London IM, Humphries RK, Leboulch P. Preselection of retrovirally transduced bone marrow avoids subsequent stem cell gene silencing and age-dependent extinction of expression of human beta-globin in engrafted mice. Proceedings of the National Academy of Sciences of the United States of America. 97: 5411-5. PMID 10792053 DOI: 10.1073/Pnas.100082597  0.43
2000 Hogge DE, Lambie K, Sutherland HJ, Benny WB, Dalal B, Currie C, Barnett MJ, Eaves AC, Eaves CJ. Quantitation of primitive and lineage-committed progenitors in mobilized peripheral blood for prediction of platelet recovery post autologous transplant Bone Marrow Transplantation. 25: 589-598. PMID 10734292 DOI: 10.1038/Sj.Bmt.1702211  0.455
2000 Hennemann B, Chuo JY, Schley PD, Lambie K, Humphries RK, Eaves CJ. High-efficiency retroviral transduction of mammalian cells on positively charged surfaces. Human Gene Therapy. 11: 43-51. PMID 10646638 DOI: 10.1089/10430340050016148  0.572
2000 Hennemann B, Oh I, Chuo JY, Kalberer CP, Schley PD, Rose-John S, Humphries RK, Eaves CJ. Efficient retrovirus-mediated gene transfer to transplantable human bone marrow cells in the absence of fibronectin Blood. 96: 2432-2439. DOI: 10.1182/Blood.V96.7.2432.H8002432_2432_2439  0.567
2000 Glimm H, Oh I, Eaves CJ. Human hematopoietic stem cells stimulated to proliferate in vitro lose engraftment potential during their S/G2/M transit and do not reenter G0 Blood. 96: 4185-4193. DOI: 10.1182/Blood.V96.13.4185.H8004185_4185_4193  0.578
2000 Oh I, Lau A, Eaves CJ. During ontogeny primitive (CD34+CD38−) hematopoietic cells show altered expression of a subset of genes associated with early cytokine and differentiation responses of their adult counterparts Blood. 96: 4160-4168. DOI: 10.1182/Blood.V96.13.4160  0.505
2000 Oh I, Lau A, Eaves CJ. During ontogeny primitive (CD34+CD38−) hematopoietic cells show altered expression of a subset of genes associated with early cytokine and differentiation responses of their adult counterparts Blood. 96: 4160-4168. DOI: 10.1182/BLOOD.V96.13.4160  0.408
2000 Maguer-Satta V, Oostendorp R, Reid D, Eaves CJ. Evidence that ceramide mediates the ability of tumor necrosis factor to modulate primitive human hematopoietic cell fates Blood. 96: 4118-4123. DOI: 10.1182/Blood.V96.13.4118  0.551
2000 Maguer-Satta V, Oostendorp R, Reid D, Eaves CJ. Evidence that ceramide mediates the ability of tumor necrosis factor to modulate primitive human hematopoietic cell fates Blood. 96: 4118-4123. DOI: 10.1182/BLOOD.V96.13.4118  0.463
2000 Cashman JD, Eaves CJ. High marrow seeding efficiency of human lymphomyeloid repopulating cells in irradiated NOD/SCID mice Blood. 96: 3979-3981. DOI: 10.1182/Blood.V96.12.3979  0.513
2000 Cashman JD, Eaves CJ. High marrow seeding efficiency of human lymphomyeloid repopulating cells in irradiated NOD/SCID mice Blood. 96: 3979-3981. DOI: 10.1182/BLOOD.V96.12.3979  0.418
2000 Brümmendorf TH, Holyoake TL, Rufer N, Barnett MJ, Schulzer M, Eaves CJ, Eaves AC, Lansdorp PM. Prognostic implications of differences in telomere length between normal and malignant cells from patients with chronic myeloid leukemia measured by flow cytometry Blood. 95: 1883-1890. DOI: 10.1182/Blood.V95.6.1883  0.436
2000 Oostendorp RAJ, Audet J, Eaves CJ. High-resolution tracking of cell division suggests similar cell cycle kinetics of hematopoietic stem cells stimulated in vitro and in vivo Blood. 95: 855-862. DOI: 10.1182/Blood.V95.3.855.003K41_855_862  0.592
2000 Cashman J, Clark-Lewis I, Eaves C. SDF-1 And tgf-β enhance the detection of transplantable human stem cells regenerating in nod/scid mice Experimental Hematology. 28: 85. DOI: 10.1016/S0301-472X(00)00352-0  0.524
2000 Buske C, Feuring-Buske M, Antonchuk J, Rosten P, Hogge D, Eaves C, Humphries R. HOXA10-Overexpression causes severe perturbations in human hematopoiesis Experimental Hematology. 28: 84. DOI: 10.1016/S0301-472X(00)00349-0  0.556
2000 Peters CE, Clarke E, Glimm H, Lansdorp PM, Eaves CJ, Thomas TE. 50-FOLD Enrichment of CD34+ cells directly from cord blood in a single density separation Experimental Hematology. 28: 48. DOI: 10.1016/S0301-472X(00)00239-3  0.425
1999 Jiang X, Lopez A, Holyoake T, Eaves A, Eaves C. Autocrine production and action of IL-3 and granulocyte colony-stimulating factor in chronic myeloid leukemia. Proceedings of the National Academy of Sciences of the United States of America. 96: 12804-9. PMID 10536003 DOI: 10.1073/Pnas.96.22.12804  0.489
1999 Holyoake TL, Nicolini FE, Eaves CJ. Functional differences between transplantable human hematopoietic stem cells from fetal liver, cord blood, and adult marrow. Experimental Hematology. 27: 1418-27. PMID 10480433 DOI: 10.1016/S0301-472X(99)00078-8  0.579
1999 Eaves C, Miller C, Conneally E, Audet J, Oostendorp R, Cashman J, Zandstra P, Rose-John S, Piret J, Eaves A. Introduction to stem cell biology in vitro. Threshold to the future. Annals of the New York Academy of Sciences. 872: 1-8. PMID 10372105 DOI: 10.1111/J.1749-6632.1999.Tb08447.X  0.812
1999 Hennemann B, Conneally E, Pawliuk R, Leboulch P, Rose-John S, Reid D, Chuo JY, Humphries RK, Eaves CJ. Optimization of retroviral-mediated gene transfer to human NOD/SCID mouse repopulating cord blood cells through a systematic analysis of protocol variables. Experimental Hematology. 27: 817-25. PMID 10340397 DOI: 10.1016/S0301-472X(99)00021-1  0.567
1999 Oostendorp RAJ, Audet J, Miller C, Eaves CJ. Cell division tracking and expansion of hematopoietic long-term repopulating cells. Leukemia. 13: 499-501. PMID 10214853 DOI: 10.1038/Sj.Leu.2401373  0.568
1999 Zandstra PW, Jervis E, Haynes CA, Kilburn DG, Eaves CJ, Piret JM. Concentration-dependent internalization of a cytokine/cytokine receptor complex in human hematopoietic cells. Biotechnology and Bioengineering. 63: 493-501. PMID 10099630 DOI: 10.1002/(Sici)1097-0290(19990520)63:4<493::Aid-Bit13>3.0.Co;2-0  0.793
1999 Thomas TE, Miller CL, Eaves CJ. Purification of hematopoietic stem cells for further biological study. Methods (San Diego, Calif.). 17: 202-18. PMID 10080906 DOI: 10.1006/meth.1998.0731  0.452
1999 Eaves C, Cashman J, Eaves A. Defective regulation of leukemic hematopoiesis in chronic myeloid leukemia. Leukemia Research. 22: 1085-96. PMID 9922073 DOI: 10.1016/S0145-2126(98)00113-1  0.55
1999 Nicolini FE, Holyoake TL, Cashman JD, Chu PP, Lambie K, Eaves CJ. Unique Differentiation Programs of Human Fetal Liver Stem Cells Shown Both In Vitro and In Vivo in NOD/SCID Mice Blood. 94: 2686-2695. DOI: 10.1182/Blood.V94.8.2686.420K15_2686_2695  0.75
1999 Glimm H, Eaves C. Direct Evidence for Multiple Self-Renewal Divisions of Human In Vivo Repopulating Hematopoietic Cells in Short-Term Culture Blood. 94: 2161-2168. DOI: 10.1182/BLOOD.V94.7.2161.419K32_2161_2168  0.489
1999 Holyoake T, Jiang X, Eaves C, Eaves A. Isolation of a highly quiescent subpopulation of primitive leukemic cells in chronic myeloid leukemia. Blood. 94: 2056-2064. DOI: 10.1182/Blood.V94.6.2056.418K13_2056_2064  0.57
1999 Fujisaki T, Berger MG, Rose-John S, Eaves CJ. Rapid Differentiation of a Rare Subset of Adult Human Lin−CD34−CD38− Cells Stimulated by Multiple Growth Factors In Vitro Blood. 94: 1926-1932. DOI: 10.1182/blood.v94.6.1926.418k14_1926_1932  0.471
1999 Fujisaki T, Berger MG, Rose-John S, Eaves CJ. Rapid differentiation of a rare subset of adult human lin(-)CD34(-)CD38(-) cells stimulated by multiple growth factors in vitro. Blood. 94: 1926-1932. DOI: 10.1182/Blood.V94.6.1926  0.458
1999 Cashman J, Clark-Lewis I, Eaves A, Eaves C. Differentiation Stage–Specific Regulation of Primitive Human Hematopoietic Progenitor Cycling by Exogenous and Endogenous Inhibitors in an In Vivo Model Blood. 94: 3722-3729. DOI: 10.1182/BLOOD.V94.11.3722  0.385
1999 Cashman JD, Eaves CJ. Human Growth Factor–Enhanced Regeneration of Transplantable Human Hematopoietic Stem Cells in Nonobese Diabetic/Severe Combined Immunodeficient Mice Blood. 93: 481-487. DOI: 10.1182/Blood.V93.2.481.402K20_481_487  0.54
1998 Cooper NL, Bardy P, Bacani J, Kuusk U, Dougherty GJ, Eaves CJ, Emerman JT. Correlation of CD44 expression with proliferative activity of normal human breast epithelial cells in culture. Breast Cancer Research and Treatment. 50: 143-53. PMID 9822219 DOI: 10.1023/A:1006006425904  0.476
1998 Stingl J, Eaves CJ, Kuusk U, Emerman JT. Phenotypic and functional characterization in vitro of a multipotent epithelial cell present in the normal adult human breast. Differentiation; Research in Biological Diversity. 63: 201-13. PMID 9745711 DOI: 10.1111/J.1432-0436.1998.00201.X  0.534
1998 Zandstra PW, Conneally E, Piret JM, Eaves CJ. Ontogeny-associated changes in the cytokine responses of primitive human haemopoietic cells. British Journal of Haematology. 101: 770-8. PMID 9674754 DOI: 10.1046/j.1365-2141.1998.00777.x  0.625
1998 Hogge DE, Willman CL, Kreitman RJ, Berger M, Hall PD, Kopecky KJ, McLain C, Tagge EP, Eaves CJ, Frankel AE. Malignant progenitors from patients with acute myelogenous leukemia are sensitive to a diphtheria toxin-granulocyte-macrophage colony-stimulating factor fusion protein. Blood. 92: 589-95. PMID 9657759  0.344
1998 Oostendorp RA, Spitzer E, Brandl M, Eaves CJ, Dörmer P. Evidence for differences in the mechanisms by which antibodies against CD44 promote adhesion of erythroid and granulopoietic progenitors to marrow stromal cells. British Journal of Haematology. 101: 436-45. PMID 9633883 DOI: 10.1046/J.1365-2141.1998.00746.X  0.42
1998 Audet J, Zandstra PW, Eaves CJ, Piret JM. Advances in hematopoietic stem cell culture. Current Opinion in Biotechnology. 9: 146-51. PMID 9588003 DOI: 10.1016/S0958-1669(98)80107-9  0.793
1998 Wang JCY, Lapidot T, Cashman JD, Doedens M, Addy L, Sutherland DR, Nayar R, Laraya P, Minden M, Keating A, Eaves AC, Eaves CJ, Dick JE. High level engraftment of NOD/SCID mice by primitive normal and leukemic hematopoietic cells from patients with chronic myeloid leukemia in chronic phase Blood. 91: 2406-2414. PMID 9516140 DOI: 10.1182/Blood.V91.7.2406.2406_2406_2414  0.424
1998 Cashman J, Eaves C, Sarris A, Eaves A. MCP-1, not MIP-1α, Is the Endogenous Chemokine That Cooperates With TGF-β to Inhibit the Cycling of Primitive Normal but not Leukemic (CML) Progenitors in Long-Term Human Marrow Cultures Blood. 92: 2338-2344. DOI: 10.1182/BLOOD.V92.7.2338.2338_2338_2344  0.356
1998 Frankel AE, Lilly M, Kreitman R, Hogge D, Beran M, Freedman MH, Emanuel PD, McLain C, Hall P, Tagge E, Berger M, Eaves C. Diphtheria Toxin Fused to Granulocyte-Macrophage Colony-Stimulating Factor Is Toxic to Blasts From Patients With Juvenile Myelomonocytic Leukemia and Chronic Myelomonocytic Leukemia Blood. 92: 4279-4286. DOI: 10.1182/Blood.V92.11.4279.423K26_4279_4286  0.487
1998 Conneally E, Eaves C, Humphries R. Efficient Retroviral-Mediated Gene Transfer to Human Cord Blood Stem Cells With In Vivo Repopulating Potential Blood. 91: 3487-3493. DOI: 10.1182/blood.v91.9.3487.3487_3487_3493  0.443
1997 Zandstra PW, Petzer AL, Eaves CJ, Piret JM. Cellular determinants affecting the rate of cytokine in cultures of human hematopoietic cells. Biotechnology and Bioengineering. 54: 58-66. PMID 18634073 DOI: 10.1002/(Sici)1097-0290(19970405)54:1<58::Aid-Bit7>3.0.Co;2-X  0.777
1997 Bernstein SH, Eaves CJ, Herzig R, Fay J, Lynch J, Phillips GL, Christiansen N, Reece D, Ericson S, Stephan M, Kovalsky M, Hawkins K, Rasmussen H, Devos A, Herzig GP. A randomized phase II study of BB-10010: a variant of human macrophage inflammatory protein-1alpha for patients receiving high-dose etoposide and cyclophosphamide for malignant lymphoma and breast cancer. British Journal of Haematology. 99: 888-95. PMID 9432038 DOI: 10.1046/J.1365-2141.1997.4913294.X  0.343
1997 Miller CL, Eaves CJ. Expansion in vitro of adult murine hematopoietic stem cells with transplantable lympho-myeloid reconstituting ability. Proceedings of the National Academy of Sciences of the United States of America. 94: 13648-53. PMID 9391080 DOI: 10.1073/Pnas.94.25.13648  0.608
1997 Eaves CJ, Eaves AC. Stem cell kinetics. Bailliere's Clinical Haematology. 10: 233-57. PMID 9376662 DOI: 10.1016/S0950-3536(97)80005-4  0.565
1997 Ponchio L, Eaves C, Hogge D, Perotti C, Torretta L, Cerani P, Salvaneschi L, Ascari E, Cazzola M. Both cycling and noncycling primitive progenitors continue to be mobilized into the circulation during the leukapheresis of patients pretreated with chemotherapy and G-CSF. British Journal of Haematology. 99: 394-402. PMID 9375761 DOI: 10.1046/J.1365-2141.1997.3963210.X  0.36
1997 Eaves C, Miller C, Cashman J, Conneally I, Petzer A, Zandstra P, Eaves A, Kaushansky K, Moore MAS, Dick JE, Lansdorp PM. Hematopoietic stem cells: Inferences from in vivo assays Stem Cells. 15: 1-5. PMID 9368318 DOI: 10.1002/Stem.5530150802  0.732
1997 Nordon RE, Ginsberg SS, Eaves CJ. High-resolution cell division tracking demonstrates the FLt3-ligand-dependence of human marrow CD34+CD38- cell production in vitro. British Journal of Haematology. 98: 528-39. PMID 9332305 DOI: 10.1046/J.1365-2141.1997.2823097.X  0.476
1997 Cashman J, Bockhold K, Hogge DE, Eaves AC, Eaves CJ. Sustained proliferation, multi-lineage differentiation and maintenance of primitive human haemopoietic cells in NOD/SCID mice transplanted with human cord blood. British Journal of Haematology. 98: 1026-36. PMID 9326207 DOI: 10.1046/J.1365-2141.1997.3233140.X  0.541
1997 Pawliuk R, Eaves CJ, Humphries RK. Sustained high-level reconstitution of the hematopoietic system by preselected hematopoietic cells expressing a transduced cell-surface antigen. Human Gene Therapy. 8: 1595-604. PMID 9322092 DOI: 10.1089/Hum.1997.8.13-1595  0.542
1997 Bardy P, Conneally E, Emerman JT, Lansdorp PM, Goss G, Humphries RK, Eaves CJ. Isolation and analysis of different subpopulations of normal human breast epithelial cells after their infection with a retroviral vector encoding a cell surface marker. Breast Cancer Research and Treatment. 44: 153-65. PMID 9232274 DOI: 10.1023/A:1005713419023  0.47
1997 Cashman JD, Lapidot T, Wang JC, Doedens M, Shultz LD, Lansdorp P, Dick JE, Eaves CJ. Kinetic evidence of the regeneration of multilineage hematopoiesis from primitive cells in normal human bone marrow transplanted into immunodeficient mice. Blood. 89: 4307-16. PMID 9192753 DOI: 10.1182/Blood.V89.12.4307  0.573
1997 Ghaffari S, Dougherty GJ, Eaves AC, Eaves CJ. Diverse effects of anti-CD44 antibodies on the stromal cell-mediated support of normal but not leukaemic (CML) haemopoiesis in vitro. British Journal of Haematology. 97: 22-8. PMID 9136938 DOI: 10.1046/J.1365-2141.1997.D01-2139.X  0.439
1997 Zandstra PW, Conneally E, Petzer AL, Piret JM, Eaves CJ. Cytokine manipulation of primitive human hematopoietic cell self-renewal. Proceedings of the National Academy of Sciences of the United States of America. 94: 4698-703. PMID 9114054 DOI: 10.1073/Pnas.94.9.4698  0.779
1997 Hogge D, Fanning S, Bockhold K, Petzer A, Lambie K, Lansdorp P, Eaves A, Eaves C. Quantitation and characterization of human megakaryocyte colony-forming cells using a standardized serum-free agarose assay. British Journal of Haematology. 96: 790-800. PMID 9074423 DOI: 10.1046/J.1365-2141.1997.D01-2092.X  0.488
1997 Emerman JT, Stingl J, Petersen A, Shpall EJ, Eaves CJ. Selective growth of freshly isolated human breast epithelial cells cultured at low concentrations in the presence or absence of bone marrow cells. Breast Cancer Research and Treatment. 41: 147-59. PMID 8944333 DOI: 10.1007/Bf01807160  0.471
1997 Petzer A, Eaves C, Barnett M, Eaves A. Selective Expansion of Primitive Normal Hematopoietic Cells in Cytokine-Supplemented Cultures of Purified Cells From Patients With Chronic Myeloid Leukemia Blood. 90: 64-69. DOI: 10.1182/Blood.V90.1.64.64_64_69  0.482
1997 Miller CL, Rebel VI, Helgason CD, Lansdorp PM, Eaves CJ. Impaired Steel Factor Responsiveness Differentially Affects the Detection and Long-Term Maintenance of Fetal Liver Hematopoietic Stem Cells In Vivo Blood. 89: 1214-1223. DOI: 10.1182/Blood.V89.4.1214  0.582
1996 Petzer AL, Zandstra PW, Piret JM, Eaves CJ. Differential cytokine effects on primitive (CD34+CD38-) human hematopoietic cells: novel responses to Flt3-ligand and thrombopoietin. The Journal of Experimental Medicine. 183: 2551-8. PMID 8676076 DOI: 10.1084/Jem.183.6.2551  0.757
1996 Petzer AL, Hogge DE, Landsdorp PM, Reid DS, Eaves CJ. Self-renewal of primitive human hematopoietic cells (long-term-culture-initiating cells) in vitro and their expansion in defined medium. Proceedings of the National Academy of Sciences of the United States of America. 93: 1470-4. PMID 8643656 DOI: 10.1073/Pnas.93.4.1470  0.514
1996 Sirard C, Lapidot T, Vormoor J, Cashman JD, Doedens M, Murdoch B, Jamal N, Messner H, Addey L, Minden M, Laraya P, Keating A, Eaves A, Lansdorp PM, Eaves CJ, et al. Normal and leukemic SCID-repopulating cells (SRC) coexist in the bone marrow and peripheral blood from CML patients in chronic phase, whereas leukemic SRC are detected in blast crisis Blood. 87: 1539-1548. PMID 8608245  0.435
1996 Pawliuk R, Eaves C, Humphries R. Evidence of both ontogeny and transplant dose-regulated expansion of hematopoietic stem cells in vivo. Blood. 88: 2852-2858. DOI: 10.1182/Blood.V88.8.2852.Bloodjournal8882852  0.535
1996 Petzer A, Eaves C, Lansdorp P, Ponchio L, Barnett M, Eaves A. Characterization of primitive subpopulations of normal and leukemic cells present in the blood of patients with newly diagnosed as well as established chronic myeloid leukemia Blood. 88: 2162-2171. DOI: 10.1182/Blood.V88.6.2162.Bloodjournal8862162  0.373
1996 Maguer-Satta V, Petzer A, Eaves A, Eaves C. BCR-ABL expression in different subpopulations of functionally characterized Ph+ CD34+ cells from patients with chronic myeloid leukemia Blood. 88: 1796-1804. DOI: 10.1182/blood.V88.5.1796.bloodjournal8851796  0.437
1996 Lemieux M, Eaves C. Identification of properties that can distinguish primitive populations of stromal-cell-responsive lympho-myeloid cells from cells that are stromal-cell-responsive but lymphoid-restricted and cells that have lympho-myeloid potential but are also capable of competitively repopulating myeloablated recipients Blood. 88: 1639-1648. DOI: 10.1182/Blood.V88.5.1639.Bloodjournal8851639  0.522
1996 Hogge D, Lansdorp P, Reid D, Gerhard B, Eaves C. Enhanced detection, maintenance, and differentiation of primitive human hematopoietic cells in cultures containing murine fibroblasts engineered to produce human steel factor, interleukin-3, and granulocyte colony-stimulating factor Blood. 88: 3765-3773. DOI: 10.1182/Blood.V88.10.3765.Bloodjournal88103765  0.33
1996 Rebel V, Miller C, Eaves C, Lansdorp P. The repopulation potential of fetal liver hematopoietic stem cells in mice exceeds that of their liver adult bone marrow counterparts Blood. 87: 3500-3507. DOI: 10.1182/Blood.V87.8.3500.Bloodjournal8783500  0.486
1996 Conneally E, Bardy P, Eaves C, Thomas T, Chappel S, Shpall E, Humphries R. Rapid and efficient selection of human hematopoietic cells expressing murine heat-stable antigen as an indicator of retroviral-mediated gene transfer Blood. 87: 456-464. DOI: 10.1182/Blood.V87.2.456.Bloodjournal872456  0.551
1995 Sutherland HJ, Hogge DE, Lansdorp PM, Phillips GL, Eaves AC, Eaves CJ. Quantitation, mobilization, and clinical use of long-term culture-initiating cells in blood cell autografts. Journal of Hematotherapy. 4: 3-10. PMID 7757397 DOI: 10.1089/scd.1.1995.4.3  0.415
1995 Sauvageau G, Thorsteinsdottir U, Eaves CJ, Lawrence HJ, Largman C, Lansdorp PM, Humphries RK. Overexpression of HOXB4 in hematopoietic cells causes the selective expansion of more primitive populations in vitro and in vivo Genes and Development. 9: 1753-1765. PMID 7622039 DOI: 10.1101/Gad.9.14.1753  0.595
1995 Ponchio L, Conneally E, Eaves C. Quantitation of the quiescent fraction of long-term culture-initiating cells in normal human blood and marrow and the kinetics of their growth factor-stimulated entry into S-phase in vitro. Blood. 86: 3314-3321. DOI: 10.1182/Blood.V86.9.3314.Bloodjournal8693314  0.427
1995 Ghaffari S, Dougherty G, Lansdorp P, Eaves A, Eaves C. Differentiation-associated changes in CD44 isoform expression during normal hematopoiesis and their alteration in chronic myeloid leukemia Blood. 86: 2976-2985. DOI: 10.1182/blood.V86.8.2976.bloodjournal8682976  0.31
1995 Ghaffari S, Dougherty G, Lansdorp P, Eaves A, Eaves C. Differentiation-associated changes in CD44 isoform expression during normal hematopoiesis and their alteration in chronic myeloid leukemia Blood. 86: 2976-2985. DOI: 10.1182/Blood.V86.8.2976.2976  0.31
1995 Lemieux M, Rebel V, Lansdorp P, Eaves C. Characterization and purification of a primitive hematopoietic cell type in adult mouse marrow capable of lymphomyeloid differentiation in long-term marrow "switch" cultures Blood. 86: 1339-1347. DOI: 10.1182/Blood.V86.4.1339.Bloodjournal8641339  0.557
1995 Klingemann HG, Eaves CJ, Barnett MJ, Eaves AC, Hogge DE, Lansdorp P, Nantel SH, Reece DE, Shepherd JD, Sutherland HJ, Phillips GL. Autologous transplantation in patients with acute myeloid leukemia in first remission with IL-2-cultured marrow or peripheral blood stem cells followed by in vivo IL-2 Oncology Research and Treatment. 18: 44-47. DOI: 10.1159/000218553  0.327
1994 Eaves AC, Eaves CJ, Phillips GL, Barnett MJ. Culture purging in leukemia: past, present, and future. Leukemia & Lymphoma. 259-63. PMID 8251907 DOI: 10.3109/10428199309047896  0.424
1994 Eaves C, Udomsakdi C, Cashman J, Barnett M, Eaves A. The biology of normal and neoplastic stem cells in CML. Leukemia & Lymphoma. 245-53. PMID 8251904 DOI: 10.3109/10428199309047894  0.574
1994 Hogge DE, Sutherland HJ, Cashman JD, Lansdorp PM, Humphries RK, Eaves CJ. Cytokines acting early in human haematopoiesis. Bailliere's Clinical Haematology. 7: 49-63. PMID 8038499 DOI: 10.1016/S0950-3536(05)80006-X  0.54
1994 Eaves CJ, Cashman JD, Zoumbos NC, Barnett MJ, Eaves AC. Biological strategies for the selective manipulation of normal and leukemic stem cells. Stem Cells (Dayton, Ohio). 109-21. PMID 7905319 DOI: 10.1002/Stem.5530110924  0.431
1994 Sauvageau G, Lansdorp PM, Eaves CJ, Hogge DE, Dragowska WH, Reid DS, Largman C, Lawrence HJ, Humphries RK. Differential expression of homeobox genes in functionally distinct CD34+ subpopulations of human bone marrow cells Proceedings of the National Academy of Sciences of the United States of America. 91: 12223-12227. PMID 7527557 DOI: 10.1073/Pnas.91.25.12223  0.469
1994 Zandstra PW, Eaves CJ, Piret JM. Expansion of hematopoietic progenitor cell populations in stirred suspension bioreactors of normal human bone marrow cells. Bio/Technology (Nature Publishing Company). 12: 909-14. PMID 7521647 DOI: 10.1038/Nbt0994-909  0.78
1994 Cashman J, Eaves A, Eaves C. The tetrapeptide AcSDKP specifically blocks the cycling of primitive normal but not leukemic progenitors in long-term culture: evidence for an indirect mechanism Blood. 84: 1534-1542. DOI: 10.1182/blood.v84.5.1534.bloodjournal8451534  0.368
1994 Sutherland H, Eaves C, Lansdorp P, Phillips G, Hogge D. Kinetics of committed and primitive blood progenitor mobilization after chemotherapy and growth factor treatment and their use in autotransplants Blood. 83: 3808-3814. DOI: 10.1182/blood.v83.12.3808.bloodjournal83123808  0.404
1994 Sutherland H, Eaves C, Lansdorp P, Phillips G, Hogge D. Kinetics of committed and primitive blood progenitor mobilization after chemotherapy and growth factor treatment and their use in autotransplants Blood. 83: 3808-3814. DOI: 10.1182/Blood.V83.12.3808.3808  0.405
1994 Rebel V, Dragowska W, Eaves C, Humphries R, Lansdorp P. Amplification of Sca-1+ Lin-WGA+ cells in serum-free cultures containing steel factor, interleukin-6, and erythropoietin with maintenance of cells with long-term in vivo reconstituting potential Blood. 83: 128-136. DOI: 10.1182/Blood.V83.1.128.Bloodjournal831128  0.592
1994 Rebel V, Dragowska W, Eaves C, Humphries R, Lansdorp P. Amplification of Sca-1+ Lin-WGA+ cells in serum-free cultures containing steel factor, interleukin-6, and erythropoietin with maintenance of cells with long-term in vivo reconstituting potential Blood. 83: 128-136. DOI: 10.1182/blood.V83.1.128.128  0.512
1993 Eaves CJ, Cashman JD, Wolpe SD, Eaves AC. Unresponsiveness of primitive chronic myeloid leukemia cells to macrophage inflammatory protein 1 alpha, an inhibitor of primitive normal hematopoietic cells. Proceedings of the National Academy of Sciences of the United States of America. 90: 12015-9. PMID 8265663 DOI: 10.1073/Pnas.90.24.12015  0.464
1993 Barnett MJ, Eaves CJ, Phillips GL, Hogge DE, Klingemann HG, Lansdorp PM, Nantel SH, Reece DE, Shepherd JD, Sutherland HJ. Autografting in chronic myeloid leukemia with cultured marrow: update of the Vancouver Study. Stem Cells (Dayton, Ohio). 11: 64-6. PMID 7905324 DOI: 10.1002/Stem.5530110916  0.384
1993 Sutherland H, Hogge D, Cook D, Eaves C. Alternative mechanisms with and without steel factor support primitive human hematopoiesis Blood. 81: 1465-1470. DOI: 10.1182/blood.v81.6.1465.bloodjournal8161465  0.406
1992 Udomsakdi C, Eaves CJ, Swolin B, Reid DS, Barnett MJ, Eaves AC. Rapid decline of chronic myeloid leukemic cells in long-term culture due to a defect at the leukemic stem cell level. Proceedings of the National Academy of Sciences of the United States of America. 89: 6192-6. PMID 1631107 DOI: 10.1073/pnas.89.13.6192  0.356
1992 Hughes PF, Thacker JD, Hogge D, Sutherland HJ, Thomas TE, Lansdorp PM, Eaves CJ, Humphries RK. Retroviral gene transfer to primitive normal and leukemic hematopoietic cells using clinically applicable procedures. The Journal of Clinical Investigation. 89: 1817-24. PMID 1601991 DOI: 10.1172/Jci115786  0.482
1992 Turhan AG, Cashman JD, Eaves CJ, Humphries RK, Eaves AC. Variable expression of features of normal and neoplastic stem cells in patients with thrombocytosis British Journal of Haematology. 82: 50-57. PMID 1419802 DOI: 10.1111/J.1365-2141.1992.Tb04593.X  0.37
1992 Fraser CC, Szilvassy SJ, Eaves CJ, Humphries RK. Proliferation of totipotent hematopoietic stem cells in vitro with retention of long-term competitive in vivo reconstituting ability. Proceedings of the National Academy of Sciences of the United States of America. 89: 1968-72. PMID 1311857 DOI: 10.1073/pnas.89.5.1968  0.492
1992 Udomsakdi C, Eaves C, Lansdorp P, Eaves A. Phenotypic heterogeneity of primitive leukemic hematopoietic cells in patients with chronic myeloid leukemia Blood. 80: 2522-2530. DOI: 10.1182/blood.v80.10.2522.bloodjournal80102522  0.462
1992 Udomsakdi C, Eaves C, Lansdorp P, Eaves A. Phenotypic heterogeneity of primitive leukemic hematopoietic cells in patients with chronic myeloid leukemia Blood. 80: 2522-2530. DOI: 10.1182/Blood.V80.10.2522.2522  0.462
1992 Udomsakdi C, Lansdorp P, Hogge D, Reid D, Eaves A, Eaves C. Characterization of primitive hematopoietic cells in normal human peripheral blood Blood. 80: 2513-2521. DOI: 10.1182/blood.V80.10.2513.bloodjournal80102513  0.42
1992 Wognum A, Krystal G, Eaves C, Eaves A, Lansdorp P. Increased erythropoietin-receptor expression on CD34-positive bone marrow cells from patients with chronic myeloid leukemia Blood. 79: 642-649. DOI: 10.1182/blood.v79.3.642.bloodjournal793642  0.322
1992 Klingemann H, Deal H, Reid D, Eaves CJ. Preclinical Evaluation of a Bone-Marrow Autograft Culture Procedure for Generating Lymphokine-Activated Killer Cells in Vitro Canadian Journal of Infectious Diseases. 3: 123-127. DOI: 10.1155/1992/234936  0.506
1991 Szilvassy SJ, Humphries RK, Lansdorp PM, Eaves AC, Eaves CJ. Quantitative assay for totipotent reconstituting hematopoietic stem cells by a competitive repopulation strategy. Proceedings of the National Academy of Sciences of the United States of America. 87: 8736-40. PMID 2247442 DOI: 10.1073/Pnas.87.22.8736  0.583
1991 Otsuka T, Thacker JD, Eaves CJ, Hogge DE. Differential effects of microenvironmentally presented interleukin 3 versus soluble growth factor on primitive human hematopoietic cells. The Journal of Clinical Investigation. 88: 417-22. PMID 1864955 DOI: 10.1172/JCI115320  0.306
1991 Otsuka T, Humphries RK, Hogge DE, Eaves AC, Eaves CJ. Continuous activation of primitive hematopoietic cells in long-term human marrow cultures containing irradiated tumor cells. Journal of Cellular Physiology. 148: 370-9. PMID 1717496 DOI: 10.1002/jcp.1041480307  0.484
1991 Eaves CJ, Cashman JD, Sutherland HJ, Otsuka T, Humphries RK, Hogge DE, Lansdorp PL, Eaves AC. Molecular analysis of primitive hematopoietic cell proliferation control mechanisms. Annals of the New York Academy of Sciences. 628: 298-306. PMID 1712556 DOI: 10.1111/J.1749-6632.1991.Tb17260.X  0.603
1991 Sutherland H, Eaves C, Lansdorp P, Thacker J, Hogge D. Differential regulation of primitive human hematopoietic cells in long- term cultures maintained on genetically engineered murine stromal cells Blood. 78: 666-672. DOI: 10.1182/Blood.V78.3.666.666  0.489
1991 Eaves C, Cashman J, Kay R, Dougherty G, Otsuka T, Gaboury L, Hogge D, Lansdorp P, Eaves A, Humphries R. Mechanisms that regulate the cell cycle status of very primitive hematopoietic cells in long-term human marrow cultures. II. Analysis of positive and negative regulators produced by stromal cells within the adherent layer Blood. 78: 110-117. DOI: 10.1182/blood.v78.1.110.bloodjournal781110  0.374
1991 Hogge D, Cashman J, Humphries R, Eaves C. Differential and synergistic effects of human granulocyte-macrophage colony-stimulating factor and human granulocyte colony-stimulating factor on hematopoiesis in human long-term marrow cultures Blood. 77: 493-499. DOI: 10.1182/Blood.V77.3.493.Bloodjournal773493  0.418
1991 Hogge D, Cashman J, Humphries R, Eaves C. Differential and synergistic effects of human granulocyte-macrophage colony-stimulating factor and human granulocyte colony-stimulating factor on hematopoiesis in human long-term marrow cultures Blood. 77: 493-499. DOI: 10.1182/blood.v77.3.493.493  0.304
1991 Eaves CJ, Cashman JD, Eaves AC. Methodology of long-term culture of human hemopoietic cells Journal of Tissue Culture Methods. 13: 55-61. DOI: 10.1007/Bf01666132  0.517
1990 Sutherland HJ, Lansdorp PM, Henkelman DH, Eaves AC, Eaves CJ. Functional characterization of individual human hematopoietic stem cells cultured at limiting dilution on supportive marrow stromal layers. Proceedings of the National Academy of Sciences of the United States of America. 87: 3584-8. PMID 2333304 DOI: 10.1073/Pnas.87.9.3584  0.599
1990 Lansdorp PM, Sutherland HJ, Eaves CJ. Selective expression of CD45 isoforms on functional subpopulations of CD34+ hemopoietic cells from human bone marrow. The Journal of Experimental Medicine. 172: 363-6. PMID 1694223 DOI: 10.1084/Jem.172.1.363  0.577
1990 Fraser C, Eaves C, Szilvassy S, Humphries R. Expansion in vitro of retrovirally marked totipotent hematopoietic stem cells Blood. 76: 1071-1076. DOI: 10.1182/blood.V76.6.1071.bloodjournal7661071  0.482
1990 Fraser C, Eaves C, Szilvassy S, Humphries R. Expansion in vitro of retrovirally marked totipotent hematopoietic stem cells Blood. 76: 1071-1076. DOI: 10.1182/blood.v76.6.1071.1071  0.483
1990 Turhan A, Humphries R, Eaves C, Barnett M, Phillips G, Kalousek D, Klingemann H, Lansdorp P, Reece D, Shepherd J. Detection of breakpoint cluster region- negative and nonclonal hematopoiesis in vitro and in vivo after transplantation of cells selected in cultures of chronic myeloid leukemia marrow Blood. 76: 2404-2410. DOI: 10.1182/blood.V76.11.2404.bloodjournal76112404  0.469
1990 Turhan A, Humphries R, Eaves C, Barnett M, Phillips G, Kalousek D, Klingemann H, Lansdorp P, Reece D, Shepherd J. Detection of breakpoint cluster region- negative and nonclonal hematopoiesis in vitro and in vivo after transplantation of cells selected in cultures of chronic myeloid leukemia marrow Blood. 76: 2404-2410. DOI: 10.1182/blood.v76.11.2404.2404  0.469
1990 Lemoine F, Dedhar S, Lima G, Eaves C. Transformation-associated alterations in interactions between pre-B cells and fibronectin Blood. 76: 2311-2320. DOI: 10.1182/blood.v76.11.2311.bloodjournal76112311  0.374
1990 Lemoine F, Dedhar S, Lima G, Eaves C. Transformation-associated alterations in interactions between pre-B cells and fibronectin Blood. 76: 2311-2320. DOI: 10.1182/blood.v76.11.2311.2311  0.374
1990 Cashman J, Eaves A, Raines E, Ross R, Eaves C. Mechanisms that regulate the cell cycle status of very primitive hematopoietic cells in long-term human marrow cultures. I. Stimulatory role of a variety of mesenchymal cell activators and inhibitory role of TGF-beta Blood. 75: 96-101. DOI: 10.1182/Blood.V75.1.96.Bloodjournal75196  0.545
1989 Eaves CJ, Eaves AC. Cell culture studies in CML. Bailliere's Clinical Haematology. 1: 931-61. PMID 3332857 DOI: 10.1016/S0950-3536(87)80033-1  0.338
1989 Szilvassy SJ, Fraser CC, Eaves CJ, Lansdorp PM, Eaves AC, Humphries RK. Retrovirus-mediated gene transfer to purified hemopoietic stem cells with long-term lympho-myelopoietic repopulating ability. Proceedings of the National Academy of Sciences of the United States of America. 86: 8798-802. PMID 2573066 DOI: 10.1073/pnas.86.22.8798  0.472
1989 Turhan AG, Humphries RK, Phillips GL, Eaves AC, Eaves CJ. Clonal hematopoiesis demonstrated by x-linked DNA polymorphisms after allogeneic bone marrow transplantation New England Journal of Medicine. 320: 1655-1661. PMID 2566916 DOI: 10.1056/NEJM198906223202504  0.313
1989 Hughes P, Eaves C, Hogge D, Humphries R. High-efficiency gene transfer to human hematopoietic cells maintained in long-term marrow culture [see comments] Blood. 74: 1915-1922. DOI: 10.1182/blood.v74.6.1915.bloodjournal7461915  0.404
1989 Hughes P, Eaves C, Hogge D, Humphries R. High-efficiency gene transfer to human hematopoietic cells maintained in long-term marrow culture [see comments] Blood. 74: 1915-1922. DOI: 10.1182/Blood.V74.6.1915.1915  0.502
1989 Sutherland H, Eaves C, Eaves A, Dragowska W, Lansdorp P. Characterization and partial purification of human marrow cells capable of initiating long-term hematopoiesis in vitro Blood. 74: 1563-1570. DOI: 10.1182/Blood.V74.5.1563.1563  0.598
1989 Szilvassy S, Lansdorp P, Humphries R, Eaves A, Eaves C. Isolation in a single step of a highly enriched murine hematopoietic stem cell population with competitive long-term repopulating ability Blood. 74: 930-939. DOI: 10.1182/Blood.V74.3.930.Bloodjournal743930  0.456
1988 Cashman JD, Eaves CJ, Eaves AC. Unregulated proliferation of primitive neoplastic progenitor cells in long-term polycythemia vera marrow cultures. The Journal of Clinical Investigation. 81: 87-91. PMID 3335645 DOI: 10.1172/Jci113315  0.476
1988 Kalousek DK, Dubé ID, Eaves CJ, Eaves AC. Cytogenetic studies of haemopoietic colonies from patients with an initial diagnosis of acute lymphoblastic leukaemia. British Journal of Haematology. 70: 5-11. PMID 3179228 DOI: 10.1111/J.1365-2141.1988.Tb02426.X  0.317
1988 Turhan AG, Humphries RK, Cashman JD, Cuthbert DA, Eaves CJ, Eaves AC. Transient suppression of clonal hemopoiesis associated with pregnancy in a patient with a myeloproliferative disorder. The Journal of Clinical Investigation. 81: 1999-2003. PMID 2898487 DOI: 10.1172/Jci113549  0.321
1988 Wognum A, Lansdorp P, Eaves C, Krystal G. Use of a sensitive bioimmunoabsorbent assay to isolate and characterize monoclonal antibodies to biologically active human erythropoietin Blood. 71: 1731-1737. DOI: 10.1182/Blood.V71.6.1731.Bloodjournal7161731  0.323
1987 Hogge DE, Shannon KM, Kalousek DK, Schonberg S, Schaffner V, Zoger S, Eaves CJ, Eaves AC. Juvenile monosomy 7 syndrome: evidence that the disease originates in a pluripotent hemopoietic stem cell. Leukemia Research. 11: 705-9. PMID 3626612 DOI: 10.1016/0145-2126(87)90006-3  0.435
1987 Hogge DE, Coulombel L, Kalousek DK, Eaves CJ, Eaves AC. Nonclonal hemopoietic progenitors in a G6PD heterozygote with chronic myelogenous leukemia revealed after long-term marrow culture. American Journal of Hematology. 24: 389-94. PMID 3471084 DOI: 10.1002/Ajh.2830240408  0.44
1987 Eaves AC, Cashman JD, Gaboury LA, Eaves CJ, Singer JW. Clinical signficance of long-term cultures of myeloid blood cells Critical Reviews in Oncology and Hematology. 7: 125-138. PMID 3311425 DOI: 10.1016/S1040-8428(87)80022-7  0.584
1987 Fraser C, Eaves CJ, Kalousek DK. Fluorodeoxyuridine synchronization of hemopoietic colonies. Cancer Genetics and Cytogenetics. 24: 1-6. PMID 2947674 DOI: 10.1016/0165-4608(87)90077-X  0.396
1986 Wong PM, Chung SW, Chui DH, Eaves CJ. Properties of the earliest clonogenic hemopoietic precursors to appear in the developing murine yolk sac. Proceedings of the National Academy of Sciences of the United States of America. 83: 3851-4. PMID 3012535 DOI: 10.1073/pnas.83.11.3851  0.323
1986 Chung S, Wong P, Shen-Ong G, Ruscetti S, Ishizaka T, Eaves C. Production of granulocyte-macrophage colony-stimulating factor by Abelson virus-induced tumorigenic mast cell lines Blood. 68: 1074-1081. DOI: 10.1182/blood.V68.5.1074.1074  0.352
1986 Askew D, Eaves A, Eaves C, Takei F. Restricted expression of a new acute myelogenous leukemia-associated antigen (NHL-30.5) on normal hemopoietic progenitor cells Blood. 67: 1098-1102. DOI: 10.1182/Blood.V67.4.1098.Bloodjournal6741098  0.467
1985 Eaves CJ, Krystal G, Eaves AC. Erythropoietic cells. Bibliotheca Haematologica. 81-111. PMID 6532449 DOI: 10.1159/000408404  0.427
1985 Kerk DK, Henry EA, Eaves AC, Eaves CJ. Two classes of primitive pluripotent hemopoietic progenitor cells: separation by adherence. Journal of Cellular Physiology. 125: 127-34. PMID 4044666 DOI: 10.1002/Jcp.1041250117  0.542
1985 Coulombel L, Eaves C, Kalousek D, Gupta C, Eaves A. Long-term marrow culture of cells from patients with acute myelogenous leukemia. Selection in favor of normal phenotypes in some but not all cases. Journal of Clinical Investigation. 75: 961-969. PMID 3856572 DOI: 10.1172/Jci111797  0.461
1985 Cashman J, Eaves A, Eaves C. Regulated proliferation of primitive hematopoietic progenitor cells in long-term human marrow cultures Blood. 66: 1002-1005. DOI: 10.1182/blood.v66.4.1002.bloodjournal6641002  0.455
1985 Cashman J, Eaves A, Eaves C. Regulated proliferation of primitive hematopoietic progenitor cells in long-term human marrow cultures Blood. 66: 1002-1005. DOI: 10.1182/blood.v66.4.1002.1002  0.455
1984 Dubé ID, Gupta CM, Kalousek DK, Eaves CJ, Eaves AC. Cytogenetic studies of early myeloid progenitor compartments in Ph1-positive chronic myeloid leukaemia (CML). I. Persistence of Ph1-negative committed progenitors that are suppressed from differentiating in vivo. British Journal of Haematology. 56: 633-44. PMID 6585219 DOI: 10.1111/J.1365-2141.1984.Tb02187.X  0.459
1984 Krystal G, Eaves CJ, Eaves AC. CM Affi-Gel Blue chromatography of human urine: a simple one-step procedure for obtaining erythropoietin suitable for in vitro erythropoietic progenitor assays. British Journal of Haematology. 58: 533-46. PMID 6498104 DOI: 10.1111/J.1365-2141.1984.Tb04001.X  0.324
1984 Dube I, Arlin Z, Kalousek D, Eaves C, Eaves A. Nonclonal hemopoietic progenitor cells detected in long-term marrow cultures from a Turner syndrome mosaic with chronic myeloid leukemia Blood. 64: 1284-1287. DOI: 10.1182/blood.V64.6.1284.bloodjournal6461284  0.315
1984 Dube I, Arlin Z, Kalousek D, Eaves C, Eaves A. Nonclonal hemopoietic progenitor cells detected in long-term marrow cultures from a Turner syndrome mosaic with chronic myeloid leukemia Blood. 64: 1284-1287. DOI: 10.1182/blood.v64.6.1284.1284  0.315
1983 Greenberger JS, Sakakeeny MA, Humphries RK, Eaves CJ, Eckner RJ. Demonstration of permanent factor-dependent multipotential (erythroid/neutrophil/basophil) hematopoietic progenitor cell lines. Proceedings of the National Academy of Sciences of the United States of America. 80: 2931-5. PMID 6574462 DOI: 10.1073/Pnas.80.10.2931  0.553
1983 Coulombel L, Kalousek DK, Eaves CJ, Gupta CM, Eaves AC. Long-term marrow culture reveals chromosomally normal hematopoietic progenitor cells in patients with Philadelphia chromosome-positive chronic myelogenous leukemia. The New England Journal of Medicine. 308: 1493-8. PMID 6574315 DOI: 10.1056/Nejm198306233082502  0.421
1983 Coulombel L, Eaves A, Eaves C. Enzymatic treatment of long-term human marrow cultures reveals the preferential location of primitive hemopoietic progenitors in the adherent layer Blood. 62: 291-297. DOI: 10.1182/Blood.V62.2.291.Bloodjournal622291  0.439
1982 Dubé ID, Eaves CJ, Kalousek DK, Eaves AC. A method for obtaining high quality chromosome preparations from single hemopoietic colonies on a routine basis. Cancer Genetics and Cytogenetics. 4: 157-68. PMID 6949629 DOI: 10.1016/0165-4608(81)90080-7  0.45
1981 Humphries RK, Eaves AC, Eaves CJ. Self-renewal of hemopoietic stem cells during mixed colony formation in vitro. Proceedings of the National Academy of Sciences of the United States of America. 78: 3629-33. PMID 6943564 DOI: 10.1073/pnas.78.6.3629  0.49
1979 Humphries RK, Jacky PB, Dill FJ, Eaves AC, Eaves CJ. CFU-S in individual erythroid colonies derived in vitro from adult mouse marrow Nature. 279: 718-720. PMID 450121 DOI: 10.1038/279718A0  0.518
1979 Douglas BG, Henkelman RM, Lam GKY, Fowler JF, Eaves CJ. Practical and Theoretical Considerations in the Use of the Mouse Foot System to Derive Epithelial Stem Cell Survival Parameters Radiation Research. 77: 453. DOI: 10.2307/3575157  0.351
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