Connie J. Eaves - Publications

Affiliations: 
University of British Columbia, Vancouver, Vancouver, BC, Canada 
Area:
Cell Biology
Website:
https://www.bme.ubc.ca/person/connie-eaves/

82 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Knapp DJHF, Hammond CA, Wang F, Aghaeepour N, Miller PH, Beer PA, Pellacani D, VanInsberghe M, Hansen C, Bendall SC, Nolan GP, Eaves CJ. A topological view of human CD34+ cell state trajectories from integrated single-cell output and proteomic data. Blood. PMID 30622121 DOI: 10.1182/blood-2018-10-878025  0.44
2017 Knapp DJ, Hammond CA, Miller PH, Rabu GM, Beer PA, Ricicova M, Lecault V, Da Costa D, VanInsberghe M, Cheung AM, Pellacani D, Piret J, Hansen C, Eaves CJ. Dissociation of Survival, Proliferation, and State Control in Human Hematopoietic Stem Cells. Stem Cell Reports. 8: 152-162. PMID 28076756 DOI: 10.1016/j.stemcr.2016.12.003  0.44
2016 Knapp DJ, Hammond CA, Aghaeepour N, Miller PH, Pellacani D, Beer PA, Sachs K, Qiao W, Wang W, Humphries RK, Sauvageau G, Zandstra PW, Bendall SC, Nolan GP, Hansen C, ... Eaves CJ, et al. Distinct signaling programs control human hematopoietic stem cell survival and proliferation. Blood. PMID 27827829 DOI: 10.1182/blood-2016-09-740654  1
2016 Sawai CM, Babovic S, Upadhaya S, Knapp DJ, Lavin Y, Lau CM, Goloborodko A, Feng J, Fujisaki J, Ding L, Mirny LA, Merad M, Eaves CJ, Reizis B. Hematopoietic Stem Cells Are the Major Source of Multilineage Hematopoiesis in Adult Animals. Immunity. PMID 27590115 DOI: 10.1016/j.immuni.2016.08.007  1
2015 Nguyen LV, Pellacani D, Lefort S, Kannan N, Osako T, Makarem M, Cox CL, Kennedy W, Beer P, Carles A, Moksa M, Bilenky M, Balani S, Babovic S, Sun I, ... ... Eaves CJ, et al. Barcoding reveals complex clonal dynamics of de novo transformed human mammary cells. Nature. PMID 26633636 DOI: 10.1038/nature15742  1
2015 Kang SY, Kannan N, Zhang L, Martinez V, Rosin MP, Eaves CJ. Characterization of Epithelial Progenitors in Normal Human Palatine Tonsils and Their HPV16 E6/E7-Induced Perturbation. Stem Cell Reports. PMID 26527383 DOI: 10.1016/j.stemcr.2015.09.020  1
2015 Joshi PA, Waterhouse PD, Kannan N, Narala S, Fang H, Di Grappa MA, Jackson HW, Penninger JM, Eaves C, Khokha R. RANK Signaling Amplifies WNT-Responsive Mammary Progenitors through R-SPONDIN1. Stem Cell Reports. 5: 31-44. PMID 26095608 DOI: 10.1016/j.stemcr.2015.05.012  1
2015 Patenaude A, Woerher S, Umlandt P, Wong F, Ibrahim R, Kyle A, Unger S, Fuller M, Parker J, Minchinton A, Eaves CJ, Karsan A. A novel population of local pericyte precursor cells in tumor stroma that require Notch signaling for differentiation. Microvascular Research. 101: 38-47. PMID 26092680 DOI: 10.1016/j.mvr.2015.05.004  1
2015 Sikorski DJ, Caron NJ, VanInsberghe M, Zahn H, Eaves CJ, Piret JM, Hansen CL. Clonal analysis of individual human embryonic stem cell differentiation patterns in microfluidic cultures. Biotechnology Journal. 10: 1546-54. PMID 26059045 DOI: 10.1002/biot.201500035  1
2015 Cole A, Wang Z, Coyaud E, Voisin V, Gronda M, Jitkova Y, Mattson R, Hurren R, Babovic S, Maclean N, Restall I, Wang X, Jeyaraju DV, Sukhai MA, Prabha S, ... ... Eaves CJ, et al. Inhibition of the Mitochondrial Protease ClpP as a Therapeutic Strategy for Human Acute Myeloid Leukemia. Cancer Cell. 27: 864-76. PMID 26058080 DOI: 10.1016/j.ccell.2015.05.004  1
2015 von Palffy S, Bulaeva E, Babovic S, Kannan N, Knapp DJ, Wei L, Eaves CJ, Beer PA. Dominant-negative IKAROS enhances IL-3-stimulated signaling in wild-type but not BCR-ABL1(+) mouse BA/F3 cells. Experimental Hematology. 43: 514-523.e2. PMID 25951974 DOI: 10.1016/j.exphem.2015.04.004  1
2015 Burleigh A, McKinney S, Brimhall J, Yap D, Eirew P, Poon S, Ng V, Wan A, Prentice L, Annab L, Barrett JC, Caldas C, Eaves C, Aparicio S. A co-culture genome-wide RNAi screen with mammary epithelial cells reveals transmembrane signals required for growth and differentiation. Breast Cancer Research : Bcr. 17: 4. PMID 25572802 DOI: 10.1186/s13058-014-0510-y  1
2015 Eirew P, Steif A, Khattra J, Ha G, Yap D, Farahani H, Gelmon K, Chia S, Mar C, Wan A, Laks E, Biele J, Shumansky K, Rosner J, McPherson A, ... ... Eaves CJ, et al. Dynamics of genomic clones in breast cancer patient xenografts at single-cell resolution. Nature. 518: 422-6. PMID 25470049 DOI: 10.1038/nature13952  1
2015 Beer PA, Knapp DJ, Miller PH, Kannan N, Sloma I, Heel K, Babovic S, Bulaeva E, Rabu G, Terry J, Druker BJ, Loriaux MM, Loeb KR, Radich JP, Erber WN, ... Eaves CJ, et al. Disruption of IKAROS activity in primitive chronic-phase CML cells mimics myeloid disease progression. Blood. 125: 504-15. PMID 25370416 DOI: 10.1182/blood-2014-06-581173  1
2014 Beer PA, Knapp DJ, Kannan N, Miller PH, Babovic S, Bulaeva E, Aghaeepour N, Rabu G, Rostamirad S, Shih K, Wei L, Eaves CJ. A dominant-negative isoform of IKAROS expands primitive normal human hematopoietic cells. Stem Cell Reports. 3: 841-57. PMID 25418728 DOI: 10.1016/j.stemcr.2014.09.006  1
2014 Lai CK, Moon Y, Kuchenbauer F, Starzcynowski DT, Argiropoulos B, Yung E, Beer P, Schwarzer A, Sharma A, Park G, Leung M, Lin G, Vollett S, Fung S, Eaves CJ, et al. Cell fate decisions in malignant hematopoiesis: leukemia phenotype is determined by distinct functional domains of the MN1 oncogene. Plos One. 9: e112671. PMID 25401736 DOI: 10.1371/journal.pone.0112671  1
2014 Imren S, Heuser M, Gasparetto M, Beer PA, Norddahl GL, Xiang P, Chen L, Berg T, Rhyasen GW, Rosten P, Park G, Moon Y, Weng AP, Eaves CJ, Humphries RK. Modeling de novo leukemogenesis from human cord blood with MN1 and NUP98HOXD13. Blood. 124: 3608-12. PMID 25339361 DOI: 10.1182/blood-2014-04-564666  1
2014 Chakrabarti R, Wei Y, Hwang J, Hang X, Andres Blanco M, Choudhury A, Tiede B, Romano RA, DeCoste C, Mercatali L, Ibrahim T, Amadori D, Kannan N, Eaves CJ, Sinha S, et al. ΔNp63 promotes stem cell activity in mammary gland development and basal-like breast cancer by enhancing Fzd7 expression and Wnt signalling. Nature Cell Biology. 16: 1004-15, 1-13. PMID 25241036 DOI: 10.1038/ncb3040  1
2014 Fares I, Chagraoui J, Gareau Y, Gingras S, Ruel R, Mayotte N, Csaszar E, Knapp DJ, Miller P, Ngom M, Imren S, Roy DC, Watts KL, Kiem HP, Herrington R, ... ... Eaves CJ, et al. Cord blood expansion. Pyrimidoindole derivatives are agonists of human hematopoietic stem cell self-renewal. Science (New York, N.Y.). 345: 1509-12. PMID 25237102 DOI: 10.1126/science.1256337  1
2014 Wohrer S, Knapp DJ, Copley MR, Benz C, Kent DG, Rowe K, Babovic S, Mader H, Oostendorp RA, Eaves CJ. Distinct stromal cell factor combinations can separately control hematopoietic stem cell survival, proliferation, and self-renewal. Cell Reports. 7: 1956-67. PMID 24910437 DOI: 10.1016/j.celrep.2014.05.014  1
2014 Nguyen LV, Makarem M, Carles A, Moksa M, Kannan N, Pandoh P, Eirew P, Osako T, Kardel M, Cheung AM, Kennedy W, Tse K, Zeng T, Zhao Y, Humphries RK, ... ... Eaves CJ, et al. Clonal analysis via barcoding reveals diverse growth and differentiation of transplanted mouse and human mammary stem cells. Cell Stem Cell. 14: 253-63. PMID 24440600 DOI: 10.1016/j.stem.2013.12.011  1
2014 Knapp DJ, Eaves CJ. Control of the hematopoietic stem cell state. Cell Research. 24: 3-4. PMID 24100350 DOI: 10.1038/cr.2013.139  1
2013 Kawamura E, Fielding AB, Kannan N, Balgi A, Eaves CJ, Roberge M, Dedhar S. Identification of novel small molecule inhibitors of centrosome clustering in cancer cells. Oncotarget. 4: 1763-76. PMID 24091544  1
2013 Kannan N, Huda N, Tu L, Droumeva R, Aubert G, Chavez E, Brinkman RR, Lansdorp P, Emerman J, Abe S, Eaves C, Gilley D. The luminal progenitor compartment of the normal human mammary gland constitutes a unique site of telomere dysfunction. Stem Cell Reports. 1: 28-37. PMID 24052939 DOI: 10.1016/j.stemcr.2013.04.003  1
2013 Cheung AM, Nguyen LV, Carles A, Beer P, Miller PH, Knapp DJ, Dhillon K, Hirst M, Eaves CJ. Analysis of the clonal growth and differentiation dynamics of primitive barcoded human cord blood cells in NSG mice. Blood. 122: 3129-37. PMID 24030380 DOI: 10.1182/blood-2013-06-508432  1
2013 Makarem M, Kannan N, Nguyen LV, Knapp DJ, Balani S, Prater MD, Stingl J, Raouf A, Nemirovsky O, Eirew P, Eaves CJ. Developmental changes in the in vitro activated regenerative activity of primitive mammary epithelial cells. Plos Biology. 11: e1001630. PMID 23966837 DOI: 10.1371/journal.pbio.1001630  1
2013 Copley MR, Babovic S, Benz C, Knapp DJ, Beer PA, Kent DG, Wohrer S, Treloar DQ, Day C, Rowe K, Mader H, Kuchenbauer F, Humphries RK, Eaves CJ. The Lin28b-let-7-Hmga2 axis determines the higher self-renewal potential of fetal haematopoietic stem cells. Nature Cell Biology. 15: 916-25. PMID 23811688 DOI: 10.1038/ncb2783  1
2013 Zeng F, Huang SZ, Gong ZJ, Chen MJ, Baldwin DA, Hu W, Qian H, Yan JB, Wang J, Xiao YP, Chalandon Y, Ringrose A, Ren ZR, Eaves A, Eaves C, et al. Long-term deregulated human hematopoiesis in goats transplanted in utero with BCR-ABL-transduced lin(-)CD34(+) cord blood cells. Cell Research. 23: 859-62. PMID 23628725 DOI: 10.1038/cr.2013.60  1
2013 Makarem M, Spike BT, Dravis C, Kannan N, Wahl GM, Eaves CJ. Stem cells and the developing mammary gland. Journal of Mammary Gland Biology and Neoplasia. 18: 209-19. PMID 23624881 DOI: 10.1007/s10911-013-9284-6  1
2013 Miller PH, Knapp DJ, Eaves CJ. Heterogeneity in hematopoietic stem cell populations: implications for transplantation. Current Opinion in Hematology. 20: 257-64. PMID 23615054 DOI: 10.1097/MOH.0b013e328360aaf6  1
2013 Caron NJ, Gage BK, O'Connor MD, Eaves CJ, Kieffer TJ, Piret JM. A human embryonic stem cell line adapted for high throughput screening. Biotechnology and Bioengineering. 110: 2706-16. PMID 23613129 DOI: 10.1002/bit.24936  1
2013 Miller PH, Cheung AM, Beer PA, Knapp DJ, Dhillon K, Rabu G, Rostamirad S, Humphries RK, Eaves CJ. Enhanced normal short-term human myelopoiesis in mice engineered to express human-specific myeloid growth factors. Blood. 121: e1-4. PMID 23233660 DOI: 10.1182/blood-2012-09-456566  1
2013 Sukhai MA, Prabha S, Hurren R, Rutledge AC, Lee AY, Sriskanthadevan S, Sun H, Wang X, Skrtic M, Seneviratne A, Cusimano M, Jhas B, Gronda M, MacLean N, Cho EE, ... ... Eaves C, et al. Lysosomal disruption preferentially targets acute myeloid leukemia cells and progenitors Journal of Clinical Investigation. 123: 315-328. PMID 23202731 DOI: 10.1172/JCI64180  1
2013 Woehrer S, Miller CL, Eaves CJ. Long-term culture-initiating cell assay for mouse cells. Methods in Molecular Biology (Clifton, N.J.). 946: 257-66. PMID 23179837 DOI: 10.1007/978-1-62703-128-8_16  1
2013 Liu M, Miller CL, Eaves CJ. Human long-term culture initiating cell assay. Methods in Molecular Biology (Clifton, N.J.). 946: 241-56. PMID 23179836 DOI: 10.1007/978-1-62703-128-8_15  1
2012 Giambra V, Jenkins CR, Wang H, Lam SH, Shevchuk OO, Nemirovsky O, Wai C, Gusscott S, Chiang MY, Aster JC, Humphries RK, Eaves C, Weng AP. NOTCH1 promotes T cell leukemia-initiating activity by RUNX-mediated regulation of PKC-θ and reactive oxygen species. Nature Medicine. 18: 1693-8. PMID 23086478 DOI: 10.1038/nm.2960  1
2012 Valent P, Bonnet D, De Maria R, Lapidot T, Copland M, Melo JV, Chomienne C, Ishikawa F, Schuringa JJ, Stassi G, Huntly B, Herrmann H, Soulier J, Roesch A, Schuurhuis GJ, ... ... Eaves C, et al. Cancer stem cell definitions and terminology: the devil is in the details. Nature Reviews. Cancer. 12: 767-75. PMID 23051844 DOI: 10.1038/nrc3368  1
2012 Despeaux M, Chicanne G, Rouer E, De Toni-Costes F, Bertrand J, Mansat-De Mas V, Vergnolle N, Eaves C, Payrastre B, Girault JA, Racaud-Sultan C. Focal adhesion kinase splice variants maintain primitive acute myeloid leukemia cells through altered Wnt signaling. Stem Cells (Dayton, Ohio). 30: 1597-610. PMID 22714993 DOI: 10.1002/stem.1157  1
2012 Shah SP, Roth A, Goya R, Oloumi A, Ha G, Zhao Y, Turashvili G, Ding J, Tse K, Haffari G, Bashashati A, Prentice LM, Khattra J, Burleigh A, Yap D, ... ... Eaves CJ, et al. The clonal and mutational evolution spectrum of primary triple-negative breast cancers. Nature. 486: 395-9. PMID 22495314 DOI: 10.1038/nature10933  1
2012 Nieborowska-Skorska M, Kopinski PK, Ray R, Hoser G, Ngaba D, Flis S, Cramer K, Reddy MM, Koptyra M, Penserga T, Glodkowska-Mrowka E, Bolton E, Holyoake TL, Eaves CJ, Cerny-Reiterer S, et al. Rac2-MRC-cIII-generated ROS cause genomic instability in chronic myeloid leukemia stem cells and primitive progenitors. Blood. 119: 4253-63. PMID 22411871 DOI: 10.1182/blood-2011-10-385658  1
2012 Benz C, Copley MR, Kent DG, Wohrer S, Cortes A, Aghaeepour N, Ma E, Mader H, Rowe K, Day C, Treloar D, Brinkman RR, Eaves CJ. Hematopoietic stem cell subtypes expand differentially during development and display distinct lymphopoietic programs. Cell Stem Cell. 10: 273-83. PMID 22385655 DOI: 10.1016/j.stem.2012.02.007  1
2012 Cheung AM, Leung D, Rostamirad S, Dhillon K, Miller PH, Droumeva R, Brinkman RR, Hogge D, Roy DC, Eaves CJ. Distinct but phenotypically heterogeneous human cell populations produce rapid recovery of platelets and neutrophils after transplantation. Blood. 119: 3431-9. PMID 22374695 DOI: 10.1182/blood-2011-12-398024  1
2012 Man CH, Fung TK, Ho C, Han HH, Chow HC, Ma AC, Choi WW, Lok S, Cheung AM, Eaves C, Kwong YL, Leung AY. Sorafenib treatment of FLT3-ITD(+) acute myeloid leukemia: favorable initial outcome and mechanisms of subsequent nonresponsiveness associated with the emergence of a D835 mutation. Blood. 119: 5133-43. PMID 22368270 DOI: 10.1182/blood-2011-06-363960  1
2012 Eirew P, Kannan N, Knapp DJ, Vaillant F, Emerman JT, Lindeman GJ, Visvader JE, Eaves CJ. Aldehyde dehydrogenase activity is a biomarker of primitive normal human mammary luminal cells. Stem Cells (Dayton, Ohio). 30: 344-8. PMID 22131125 DOI: 10.1002/stem.1001  1
2011 Skrti? M, Sriskanthadevan S, Jhas B, Gebbia M, Wang X, Wang Z, Hurren R, Jitkova Y, Gronda M, Maclean N, Lai CK, Eberhard Y, Bartoszko J, Spagnuolo P, Rutledge AC, ... ... Eaves CJ, et al. Inhibition of mitochondrial translation as a therapeutic strategy for human acute myeloid leukemia. Cancer Cell. 20: 674-88. PMID 22094260 DOI: 10.1016/j.ccr.2011.10.015  1
2011 Sekulovic S, Gasparetto M, Lecault V, Hoesli CA, Kent DG, Rosten P, Wan A, Brookes C, Hansen CL, Piret JM, Smith C, Eaves CJ, Humphries RK. Ontogeny stage-independent and high-level clonal expansion in vitro of mouse hematopoietic stem cells stimulated by an engineered NUP98-HOX fusion transcription factor. Blood. 118: 4366-76. PMID 21865344 DOI: 10.1182/blood-2011-04-350066  1
2011 Heuser M, Yun H, Berg T, Yung E, Argiropoulos B, Kuchenbauer F, Park G, Hamwi I, Palmqvist L, Lai CK, Leung M, Lin G, Chaturvedi A, Thakur BK, Iwasaki M, ... ... Eaves C, et al. Cell of origin in AML: susceptibility to MN1-induced transformation is regulated by the MEIS1/AbdB-like HOX protein complex. Cancer Cell. 20: 39-52. PMID 21741595 DOI: 10.1016/j.ccr.2011.06.020  1
2011 Sekulovic S, Gylfadottir V, Vulto I, Gasparetto M, Even Y, Brookes C, Smith C, Eaves CJ, Lansdorp PM, Rossi FM, Humphries RK. Prolonged self-renewal activity unmasks telomerase control of telomere homeostasis and function of mouse hematopoietic stem cells. Blood. 118: 1766-73. PMID 21730353 DOI: 10.1182/blood-2010-11-319632  1
2011 Kuchenbauer F, Mah SM, Heuser M, McPherson A, Rüschmann J, Rouhi A, Berg T, Bullinger L, Argiropoulos B, Morin RD, Lai D, Starczynowski DT, Karsan A, Eaves CJ, Watahiki A, et al. Comprehensive analysis of mammalian miRNA* species and their role in myeloid cells. Blood. 118: 3350-8. PMID 21628414 DOI: 10.1182/blood-2010-10-312454  1
2011 Lecault V, Vaninsberghe M, Sekulovic S, Knapp DJ, Wohrer S, Bowden W, Viel F, McLaughlin T, Jarandehei A, Miller M, Falconnet D, White AK, Kent DG, Copley MR, Taghipour F, ... Eaves CJ, et al. High-throughput analysis of single hematopoietic stem cell proliferation in microfluidic cell culture arrays. Nature Methods. 8: 581-6. PMID 21602799 DOI: 10.1038/nmeth.1614  1
2011 Holland DG, Burleigh A, Git A, Goldgraben MA, Perez-Mancera PA, Chin SF, Hurtado A, Bruna A, Ali HR, Greenwood W, Dunning MJ, Samarajiwa S, Menon S, Rueda OM, Lynch AG, ... ... Eaves CJ, et al. ZNF703 is a common Luminal B breast cancer oncogene that differentially regulates luminal and basal progenitors in human mammary epithelium. Embo Molecular Medicine. 3: 167-80. PMID 21337521 DOI: 10.1002/emmm.201100122  1
2010 Law JH, Li Y, To K, Wang M, Astanehe A, Lambie K, Dhillon J, Jones SJ, Gleave ME, Eaves CJ, Dunn SE. Molecular decoy to the Y-box binding protein-1 suppresses the growth of breast and prostate cancer cells whilst sparing normal cell viability. Plos One. 5. PMID 20844753 DOI: 10.1371/journal.pone.0012661  1
2010 Jiang X, Forrest D, Nicolini F, Turhan A, Guilhot J, Yip C, Holyoake T, Jorgensen H, Lambie K, Saw KM, Pang E, Vukovic R, Lehn P, Ringrose A, Yu M, ... ... Eaves C, et al. Properties of CD34+ CML stem/progenitor cells that correlate with different clinical responses to imatinib mesylate. Blood. 116: 2112-21. PMID 20574046 DOI: 10.1182/blood-2009-05-222471  1
2010 Eaves CJ, Humphries RK. Acute myeloid leukemia and the Wnt pathway. The New England Journal of Medicine. 362: 2326-7. PMID 20554989 DOI: 10.1056/NEJMcibr1003522  1
2010 To K, Fotovati A, Reipas KM, Law JH, Hu K, Wang J, Astanehe A, Davies AH, Lee L, Stratford AL, Raouf A, Johnson P, Berquin IM, Royer HD, Eaves CJ, et al. Y-box binding protein-1 induces the expression of CD44 and CD49f leading to enhanced self-renewal, mammosphere growth, and drug resistance. Cancer Research. 70: 2840-51. PMID 20332234 DOI: 10.1158/0008-5472.CAN-09-3155  1
2010 Rogers SL, Zhao Y, Jiang X, Eaves CJ, Mager DL, Rouhi A. Expression of the leukemic prognostic marker CD7 is linked to epigenetic modifications in chronic myeloid leukemia. Molecular Cancer. 9: 41. PMID 20175919 DOI: 10.1186/1476-4598-9-41  1
2010 Tacke M, Ball CR, Schmidt M, Klingenberg S, Maurer B, Fessler S, Eaves CJ, von Kalle C, Glimm H. The inherent differentiation program of short-term hematopoietic repopulating cells changes during human ontogeny. Stem Cells and Development. 19: 621-8. PMID 19788397 DOI: 10.1089/scd.2009.0202  1
2009 Vercauteren SM, Bashashati A, Wu D, Brinkman RR, Eaves C, Eaves A, Karsan A. Reduction in multi-lineage and erythroid progenitors distinguishes myelodysplastic syndromes from non-malignant cytopenias. Leukemia Research. 33: 1636-42. PMID 19414193 DOI: 10.1016/j.leukres.2009.03.019  1
2009 Kent DG, Copley MR, Benz C, Wöhrer S, Dykstra BJ, Ma E, Cheyne J, Zhao Y, Bowie MB, Zhao Y, Gasparetto M, Delaney A, Smith C, Marra M, Eaves CJ. Prospective isolation and molecular characterization of hematopoietic stem cells with durable self-renewal potential. Blood. 113: 6342-50. PMID 19377048 DOI: 10.1182/blood-2008-12-192054  1
2008 Lee C, Dhillon J, Wang MY, Gao Y, Hu K, Park E, Astanehe A, Hung MC, Eirew P, Eaves CJ, Dunn SE. Targeting YB-1 in HER-2 overexpressing breast cancer cells induces apoptosis via the mTOR/STAT3 pathway and suppresses tumor growth in mice. Cancer Research. 68: 8661-6. PMID 18974106 DOI: 10.1158/0008-5472.CAN-08-1082  1
2008 Salvagiotto G, Zhao Y, Vodyanik M, Ruotti V, Stewart R, Marra M, Thomson J, Eaves C, Slukvin I. Molecular profiling reveals similarities and differences between primitive subsets of hematopoietic cells generated in vitro from human embryonic stem cells and in vivo during embryogenesis Experimental Hematology. 36: 1377-1389. PMID 18922365 DOI: 10.1016/j.exphem.2008.06.015  1
2008 Cramer K, Nieborowska-Skorska M, Koptyra M, Slupianek A, Penserga ET, Eaves CJ, Aulitzky W, Skorski T. BCR/ABL and other kinases from chronic myeloproliferative disorders stimulate single-strand annealing, an unfaithful DNA double-strand break repair. Cancer Research. 68: 6884-8. PMID 18757400 DOI: 10.1158/0008-5472.CAN-08-1101  1
2008 Starczynowski DT, Vercauteren S, Telenius A, Sung S, Tohyama K, Brooks-Wilson A, Spinelli JJ, Eaves CJ, Eaves AC, Horsman DE, Lam WL, Karsan A. High-resolution whole genome tiling path array CGH analysis of CD34+ cells from patients with low-risk myelodysplastic syndromes reveals cryptic copy number alterations and predicts overall and leukemia-free survival. Blood. 112: 3412-24. PMID 18663149 DOI: 10.1182/blood-2007-11-122028  1
2008 Lindeman GJ, Visvader JE, Smalley MJ, Eaves CJ. The future of mammary stem cell biology: the power of in vivo transplants. Breast Cancer Research : Bcr. 10: 402; author reply 40. PMID 18522763 DOI: 10.1186/bcr1986  1
2008 Kent DG, Dykstra BJ, Cheyne J, Ma E, Eaves CJ. Steel factor coordinately regulates the molecular signature and biologic function of hematopoietic stem cells. Blood. 112: 560-7. PMID 18502833 DOI: 10.1182/blood-2007-10-117820  1
2008 Miller CL, Dykstra B, Eaves CJ. Characterization of mouse hematopoietic stem and progenitor cells. Current Protocols in Immunology / Edited by John E. Coligan ... [Et Al.]. Unit 22B.2. PMID 18432636 DOI: 10.1002/0471142735.im22b02s80  1
2008 Kent D, Copley M, Benz C, Dykstra B, Bowie M, Eaves C. Regulation of hematopoietic stem cells by the steel factor/KIT signaling pathway. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 14: 1926-30. PMID 18381929 DOI: 10.1158/1078-0432.CCR-07-5134  1
2008 Goldman FD, Aubert G, Klingelhutz AJ, Hills M, Cooper SR, Hamilton WS, Schlueter AJ, Lambie K, Eaves CJ, Lansdorp PM. Characterization of primitive hematopoietic cells from patients with dyskeratosis congenita. Blood. 111: 4523-31. PMID 18310499 DOI: 10.1182/blood-2007-10-120204  1
2007 Ungrin M, O'Connor M, Eaves C, Zandstra PW. Phenotypic analysis of human embryonic stem cells. Current Protocols in Stem Cell Biology. Unit 1B.3. PMID 18785161 DOI: 10.1002/9780470151808.sc01b03s2  1
2007 Dykstra B, Kent D, Bowie M, McCaffrey L, Hamilton M, Lyons K, Lee SJ, Brinkman R, Eaves C. Long-term propagation of distinct hematopoietic differentiation programs in vivo. Cell Stem Cell. 1: 218-29. PMID 18371352 DOI: 10.1016/j.stem.2007.05.015  1
2006 Glover CH, Marin M, Eaves CJ, Helgason CD, Piret JM, Bryan J. Meta-analysis of differentiating mouse embryonic stem cell gene expression kinetics reveals early change of a small gene set. Plos Computational Biology. 2: e158. PMID 17121458 DOI: 10.1371/journal.pcbi.0020158  1
2004 Chaudhry MA, Bowen BD, Eaves CJ, Piret JM. Empirical models of the proliferative response of cytokine-dependent hematopoietic cell lines. Biotechnology and Bioengineering. 88: 348-58. PMID 15486941 DOI: 10.1002/bit.20249  1
2002 Audet J, Miller CL, Eaves CJ, Piret JM. Common and distinct features of cytokine effects on hematopoietic stem and progenitor cells revealed by dose-response surface analysis. Biotechnology and Bioengineering. 80: 393-404. PMID 12325147 DOI: 10.1002/bit.10399  1
2001 Audet J, Miller CL, Rose-John S, Piret JM, Eaves CJ. Distinct role of gp130 activation in promoting self-renewal divisions by mitogenically stimulated murine hematopoietic stem cells. Proceedings of the National Academy of Sciences of the United States of America. 98: 1757-62. PMID 11172024 DOI: 10.1073/pnas.98.4.1757  1
2000 Zandstra PW, Lauffenburger DA, Eaves CJ. A ligand-receptor signaling threshold model of stem cell differentiation control: A biologically conserved mechanism applicable to hematopoiesis Blood. 96: 1215-1222. PMID 10942360  1
1999 Zandstra PW, Jervis E, Haynes CA, Kilburn DG, Eaves CJ, Piret JM. Concentration-dependent internalization of a cytokine/cytokine receptor complex in human hematopoietic cells. Biotechnology and Bioengineering. 63: 493-501. PMID 10099630 DOI: 10.1002/(SICI)1097-0290(19990520)63:4<493::AID-BIT13>3.0.CO;2-0  1
1998 Zandstra PW, Conneally E, Piret JM, Eaves CJ. Ontogeny-associated changes in the cytokine responses of primitive human haemopoietic cells. British Journal of Haematology. 101: 770-8. PMID 9674754 DOI: 10.1046/j.1365-2141.1998.00777.x  1
1998 Audet J, Zandstra PW, Eaves CJ, Piret JM. Advances in hematopoietic stem cell culture. Current Opinion in Biotechnology. 9: 146-51. PMID 9588003 DOI: 10.1016/S0958-1669(98)80107-9  1
1997 Zandstra PW, Petzer AL, Eaves CJ, Piret JM. Cellular determinants affecting the rate of cytokine in cultures of human hematopoietic cells. Biotechnology and Bioengineering. 54: 58-66. PMID 18634073 DOI: 10.1002/(SICI)1097-0290(19970405)54:1<58::AID-BIT7>3.0.CO;2-X  1
1997 Zandstra PW, Conneally E, Petzer AL, Piret JM, Eaves CJ. Cytokine manipulation of primitive human hematopoietic cell self-renewal. Proceedings of the National Academy of Sciences of the United States of America. 94: 4698-703. PMID 9114054 DOI: 10.1073/pnas.94.9.4698  1
1996 Petzer AL, Zandstra PW, Piret JM, Eaves CJ. Differential cytokine effects on primitive (CD34+CD38-) human hematopoietic cells: novel responses to Flt3-ligand and thrombopoietin. The Journal of Experimental Medicine. 183: 2551-8. PMID 8676076 DOI: 10.1084/jem.183.6.2551  1
1994 Zandstra PW, Eaves CJ, Piret JM. Expansion of hematopoietic progenitor cell populations in stirred suspension bioreactors of normal human bone marrow cells. Bio/Technology (Nature Publishing Company). 12: 909-14. PMID 7521647 DOI: 10.1038/nbt0994-909  1
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