Aly Karsan - Publications

University of British Columbia, Vancouver, Vancouver, BC, Canada 
Cell Biology

60 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Coulombe P, Paliouras GN, Clayton A, Hussainkhel A, Fuller M, Jovanovic V, Dauphinee S, Umlandt P, Xiang P, Kyle AH, Minchinton AI, Humphries RK, Hoodless PA, Parker JDK, Wright JL, ... Karsan A, et al. Endothelial Sash1 Is Required for Lung Maturation through Nitric Oxide Signaling. Cell Reports. 27: 1769-1780.e4. PMID 31067462 DOI: 10.1016/j.celrep.2019.04.039  0.4
2017 Yi Y, Tsai SH, Cheng JC, Wang EY, Anglesio MS, Cochrane DR, Fuller M, Gibb EA, Wei W, Huntsman DG, Karsan A, Hoodless PA. APELA promotes tumour growth and cell migration in ovarian cancer in a p53-dependent manner. Gynecologic Oncology. PMID 29079036 DOI: 10.1016/j.ygyno.2017.10.016  0.4
2016 Lund HL, Hughesman CB, Fakhfakh K, McNeil K, Clemens S, Hocken K, Pettersson R, Karsan A, Foster LJ, Haynes CA. Initial Diagnosis of ALK-positive Non-Small Cell Lung Cancer Based on Analysis of ALK Status Utilizing Droplet Digital PCR. Analytical Chemistry. PMID 27043019 DOI: 10.1021/acs.analchem.6b00707  0.4
2016 Bidshahri R, Attali D, Fakhfakh K, McNeil K, Karsan A, Won JR, Wolber R, Bryan J, Hughesman C, Haynes C. Quantitative Detection and Resolution of BRAF V600 Status in Colorectal Cancer Using Droplet Digital PCR and a Novel Wild-Type Negative Assay. The Journal of Molecular Diagnostics : Jmd. PMID 26762843 DOI: 10.1016/j.jmoldx.2015.09.003  0.4
2016 Young SS, Tucker T, Bosdet I, Karsan A. Estimating deep molecular responses in chronic myelogenous leukemia: a Bayesian approach Leukemia. DOI: 10.1038/leu.2016.37  0.4
2015 Lund HL, Hughesman CB, McNeil K, Clemens S, Hocken K, Pettersson R, Karsan A, Foster LJ, Haynes C. Initial diagnosis of chronic myelogenous leukemia based on quantification of M-BCR status using droplet digital PCR. Analytical and Bioanalytical Chemistry. PMID 26631023 DOI: 10.1007/s00216-015-9204-2  0.4
2015 Varney ME, Niederkorn M, Konno H, Matsumura T, Gohda J, Yoshida N, Akiyama T, Christie S, Fang J, Miller D, Jerez A, Karsan A, Maciejewski JP, Meetei RA, Inoue J, et al. Loss of Tifab, a del(5q) MDS gene, alters hematopoiesis through derepression of Toll-like receptor-TRAF6 signaling. The Journal of Experimental Medicine. 212: 1967-85. PMID 26458771 DOI: 10.1084/jem.20141898  0.4
2015 Huang SJ, Gillan TL, Gerrie AS, Hrynchak M, Karsan A, Ramadan K, Smith AC, Toze CL, Bruyere H. Influence of clone and deletion size on outcome in chronic lymphocytic leukemia patients with an isolated deletion 13q in a population-based analysis in British Columbia, Canada. Genes, Chromosomes & Cancer. PMID 26391112 DOI: 10.1002/gcc.22294  0.4
2015 Gentner B, Pochert N, Rouhi A, Boccalatte F, Plati T, Berg T, Sun SM, Mah SM, Mirkovic-Hösle M, Ruschmann J, Muranyi A, Leierseder S, Argiropoulos B, Starczynowski DT, Karsan A, et al. MicroRNA-223 dose levels fine tune proliferation and differentiation in human cord blood progenitors and acute myeloid leukemia. Experimental Hematology. 43: 858-868.e7. PMID 26163797 DOI: 10.1016/j.exphem.2015.05.018  0.4
2015 Patenaude A, Woerher S, Umlandt P, Wong F, Ibrahim R, Kyle A, Unger S, Fuller M, Parker J, Minchinton A, Eaves CJ, Karsan A. A novel population of local pericyte precursor cells in tumor stroma that require Notch signaling for differentiation. Microvascular Research. 101: 38-47. PMID 26092680 DOI: 10.1016/j.mvr.2015.05.004  0.4
2015 Sun H, Savage KJ, Karsan A, Slack GW, Gascoyne RD, Toze CL, Sehn LH, Abou Mourad Y, Barnett MJ, Broady RC, Connors JM, Forrest DL, Gerrie AS, Hogge DE, Narayanan S, et al. Outcome of Patients With Non-Hodgkin Lymphomas With Concurrent MYC and BCL2 Rearrangements Treated With CODOX-M/IVAC With Rituximab Followed by Hematopoietic Stem Cell Transplantation. Clinical Lymphoma, Myeloma & Leukemia. 15: 341-8. PMID 25656914 DOI: 10.1016/j.clml.2014.12.015  0.4
2015 O'Neill K, Aghaeepour N, Parker J, Hogge D, Karsan A, Dalal B, Brinkman RR. Deep profiling of multitube flow cytometry data. Bioinformatics (Oxford, England). 31: 1623-31. PMID 25600947 DOI: 10.1093/bioinformatics/btv008  0.4
2015 Kulic I, Robertson G, Chang L, Baker JH, Lockwood WW, Mok W, Fuller M, Fournier M, Wong N, Chou V, Robinson MD, Chun HJ, Gilks B, Kempkes B, Thomson TA, ... ... Karsan A, et al. Loss of the Notch effector RBPJ promotes tumorigenesis. The Journal of Experimental Medicine. 212: 37-52. PMID 25512468 DOI: 10.1084/jem.20121192  0.4
2014 Gerrie AS, Huang SJ, Bruyere H, Dalal C, Hrynchak M, Karsan A, Ramadan KM, Smith AC, Tyson C, Toze CL, Gillan TL. Population-based characterization of the genetic landscape of chronic lymphocytic leukemia patients referred for cytogenetic testing in British Columbia, Canada: the role of provincial laboratory standardization. Cancer Genetics. 207: 316-25. PMID 25441686 DOI: 10.1016/j.cancergen.2014.08.006  0.4
2014 Lai CK, Moon Y, Kuchenbauer F, Starzcynowski DT, Argiropoulos B, Yung E, Beer P, Schwarzer A, Sharma A, Park G, Leung M, Lin G, Vollett S, Fung S, Eaves CJ, ... Karsan A, et al. Cell fate decisions in malignant hematopoiesis: leukemia phenotype is determined by distinct functional domains of the MN1 oncogene. Plos One. 9: e112671. PMID 25401736 DOI: 10.1371/journal.pone.0112671  0.4
2014 Cutz JC, Craddock KJ, Torlakovic E, Brandao G, Carter RF, Bigras G, Deschenes J, Izevbaye I, Xu Z, Greer W, Yatabe Y, Ionescu D, Karsan A, Jung S, Fraser RS, et al. Canadian anaplastic lymphoma kinase study: a model for multicenter standardization and optimization of ALK testing in lung cancer. Journal of Thoracic Oncology : Official Publication of the International Association For the Study of Lung Cancer. 9: 1255-63. PMID 25122422 DOI: 10.1097/JTO.0000000000000239  0.4
2014 Chang AC, Garside VC, Fournier M, Smrz J, Vrljicak P, Umlandt P, Fuller M, Robertson G, Zhao Y, Tam A, Jones SJ, Marra MA, Hoodless PA, Karsan A. A Notch-dependent transcriptional hierarchy promotes mesenchymal transdifferentiation in the cardiac cushion. Developmental Dynamics : An Official Publication of the American Association of Anatomists. 243: 894-905. PMID 24633789 DOI: 10.1002/dvdy.24127  0.4
2014 Patenaude A, Fuller M, Chang L, Wong F, Paliouras G, Shaw R, Kyle AH, Umlandt P, Baker JH, Diaz E, Tong J, Minchinton AI, Karsan A. Endothelial-specific Notch blockade inhibits vascular function and tumor growth through an eNOS-dependent mechanism. Cancer Research. 74: 2402-11. PMID 24599126 DOI: 10.1158/0008-5472.CAN-12-4038  0.4
2014 Mariano C, Bosdet I, Karsan A, Ionescu D, Murray N, Laskin JJ, Zhai Y, Melosky B, Sun S, Ho C. A population-based review of the feasibility of platinum-based combination chemotherapy after tyrosine kinase inhibition in EGFR mutation positive non-small cell lung cancer patients with advanced disease. Lung Cancer (Amsterdam, Netherlands). 83: 73-7. PMID 24192511 DOI: 10.1016/j.lungcan.2013.10.007  0.4
2014 Wilson IM, Vucic EA, Enfield KS, Thu KL, Zhang YA, Chari R, Lockwood WW, Radulovich N, Starczynowski DT, Banáth JP, Zhang M, Pusic A, Fuller M, Lonergan KM, Rowbotham D, ... ... Karsan A, et al. EYA4 is inactivated biallelically at a high frequency in sporadic lung cancer and is associated with familial lung cancer risk. Oncogene. 33: 4464-73. PMID 24096489 DOI: 10.1038/onc.2013.396  0.4
2013 Bosdet IE, Docking TR, Butterfield YS, Mungall AJ, Zeng T, Coope RJ, Yorida E, Chow K, Bala M, Young SS, Hirst M, Birol I, Moore RA, Jones SJ, Marra MA, ... ... Karsan A, et al. A clinically validated diagnostic second-generation sequencing assay for detection of hereditary BRCA1 and BRCA2 mutations. The Journal of Molecular Diagnostics : Jmd. 15: 796-809. PMID 24094589 DOI: 10.1016/j.jmoldx.2013.07.004  0.4
2013 El-Sehemy A, Chang AC, Azad AK, Gupta N, Xu Z, Steed H, Karsan A, Fu Y. Notch activation augments nitric oxide/soluble guanylyl cyclase signaling in immortalized ovarian surface epithelial cells and ovarian cancer cells. Cellular Signalling. 25: 2780-7. PMID 24041655 DOI: 10.1016/j.cellsig.2013.09.008  0.4
2013 Swanson L, Robertson G, Mungall KL, Butterfield YS, Chiu R, Corbett RD, Docking TR, Hogge D, Jackman SD, Moore RA, Mungall AJ, Nip KM, Parker JD, Qian JQ, Raymond A, ... ... Karsan A, et al. Barnacle: detecting and characterizing tandem duplications and fusions in transcriptome assemblies. Bmc Genomics. 14: 550. PMID 23941359 DOI: 10.1186/1471-2164-14-550  0.4
2013 Ley TJ, Miller C, Ding L, Raphael BJ, Mungall AJ, Robertson G, Hoadley K, Triche TJ, Laird PW, Baty JD, Fulton LL, Fulton R, Heath SE, Kalicki-Veizer J, Kandoth C, ... ... Karsan A, et al. Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia New England Journal of Medicine. 368: 2059-2074. PMID 23634996 DOI: 10.1056/NadEJMoa1301689  0.4
2013 Chang AC, Patenaude A, Lu K, Fuller M, Ly M, Kyle A, Golbidi S, Wang Y, Walley K, Minchinton A, Laher I, Karsan A. Notch-dependent regulation of the ischemic vasodilatory response--brief report. Arteriosclerosis, Thrombosis, and Vascular Biology. 33: 510-2. PMID 23288167 DOI: 10.1161/ATVBAHA.112.300840  0.4
2013 Garside VC, Chang AC, Karsan A, Hoodless PA. Co-ordinating Notch, BMP, and TGF-β signaling during heart valve development. Cellular and Molecular Life Sciences : Cmls. 70: 2899-917. PMID 23161060 DOI: 10.1007/s00018-012-1197-9  0.4
2013 Venner CP, Woltosz JW, Nevill TJ, Deeg HJ, Caceres G, Platzbecker U, Scott BL, Sokol L, Sung S, List AF, Karsan A. Correlation of clinical response and response duration with miR-145 induction by lenalidomide in CD34(+) cells from patients with del(5q) myelodysplastic syndrome. Haematologica. 98: 409-13. PMID 22929976 DOI: 10.3324/haematol.2012.066068  0.4
2012 Vercauteren SM, Starczynowski DT, Sung S, McNeil K, Salski C, Jensen CL, Bruyere H, Lam WL, Karsan A. T cells of patients with myelodysplastic syndrome are frequently derived from the malignant clone. British Journal of Haematology. 156: 409-12. PMID 25289412 DOI: 10.1111/j.1365-2141.2011.08872.x  0.4
2012 Vrljicak P, Cullum R, Xu E, Chang AC, Wederell ED, Bilenky M, Jones SJ, Marra MA, Karsan A, Hoodless PA. Twist1 transcriptional targets in the developing atrio-ventricular canal of the mouse. Plos One. 7: e40815. PMID 22815831 DOI: 10.1371/journal.pone.0040815  0.4
2012 Chang L, Noseda M, Higginson M, Ly M, Patenaude A, Fuller M, Kyle AH, Minchinton AI, Puri MC, Dumont DJ, Karsan A. Differentiation of vascular smooth muscle cells from local precursors during embryonic and adult arteriogenesis requires Notch signaling. Proceedings of the National Academy of Sciences of the United States of America. 109: 6993-8. PMID 22509029 DOI: 10.1073/pnas.1118512109  0.4
2012 Yip S, Butterfield YS, Morozova O, Chittaranjan S, Blough MD, An J, Birol I, Chesnelong C, Chiu R, Chuah E, Corbett R, Docking R, Firme M, Hirst M, Jackman S, ... Karsan A, et al. Concurrent CIC mutations, IDH mutations, and 1p/19q loss distinguish oligodendrogliomas from other cancers. The Journal of Pathology. 226: 7-16. PMID 22072542 DOI: 10.1002/path.2995  0.4
2011 Starczynowski DT, Lockwood WW, Deléhouzée S, Chari R, Wegrzyn J, Fuller M, Tsao MS, Lam S, Gazdar AF, Lam WL, Karsan A. TRAF6 is an amplified oncogene bridging the RAS and NF-κB pathways in human lung cancer. The Journal of Clinical Investigation. 121: 4095-105. PMID 21911935 DOI: 10.1172/JCI58818  0.4
2011 Chang AC, Fu Y, Garside VC, Niessen K, Chang L, Fuller M, Setiadi A, Smrz J, Kyle A, Minchinton A, Marra M, Hoodless PA, Karsan A. Notch initiates the endothelial-to-mesenchymal transition in the atrioventricular canal through autocrine activation of soluble guanylyl cyclase. Developmental Cell. 21: 288-300. PMID 21839921 DOI: 10.1016/j.devcel.2011.06.022  0.4
2011 Kuchenbauer F, Mah SM, Heuser M, McPherson A, Rüschmann J, Rouhi A, Berg T, Bullinger L, Argiropoulos B, Morin RD, Lai D, Starczynowski DT, Karsan A, Eaves CJ, Watahiki A, et al. Comprehensive analysis of mammalian miRNA* species and their role in myeloid cells. Blood. 118: 3350-8. PMID 21628414 DOI: 10.1182/blood-2010-10-312454  0.4
2011 Wegrzyn J, Lam JC, Karsan A. Mouse models of myelodysplastic syndromes Leukemia Research. 35: 853-862. PMID 21466894 DOI: 10.1016/j.leukres.2011.03.007  0.4
2011 Fu Y, Chang AC, Fournier M, Chang L, Niessen K, Karsan A. RUNX3 maintains the mesenchymal phenotype after termination of the Notch signal. The Journal of Biological Chemistry. 286: 11803-13. PMID 21288908 DOI: 10.1074/jbc.M111.222331  0.4
2011 Starczynowski DT, Morin R, McPherson A, Lam J, Chari R, Wegrzyn J, Kuchenbauer F, Hirst M, Tohyama K, Humphries RK, Lam WL, Marra M, Karsan A. Genome-wide identification of human microRNAs located in leukemia-associated genomic alterations. Blood. 117: 595-607. PMID 20962326 DOI: 10.1182/blood-2010-03-277012  0.4
2011 Starczynowski DT, Kuchenbauer F, Wegrzyn J, Rouhi A, Petriv O, Hansen CL, Humphries RK, Karsan A. MicroRNA-146a disrupts hematopoietic differentiation and survival. Experimental Hematology. 39: 167-178.e4. PMID 20933052 DOI: 10.1016/j.exphem.2010.09.011  0.4
2011 Starczynowski DT, Vercauteren S, Sung S, Brooks-Wilson A, Lam WL, Karsan A. Copy number alterations at polymorphic loci may be acquired somatically in patients with myelodysplastic syndromes. Leukemia Research. 35: 444-7. PMID 20801506 DOI: 10.1016/j.leukres.2010.08.003  0.4
2010 Vercauteren SM, Sung S, Starczynowski DT, Lam WL, Bruyere H, Horsman DE, Tsang P, Leitch H, Karsan A. Array comparative genomic hybridization of peripheral blood granulocytes of patients with myelodysplastic syndrome detects karyotypic abnormalities. American Journal of Clinical Pathology. 134: 119-26. PMID 20551276 DOI: 10.1309/AJCPH27ZIZEJLORF  0.4
2010 Starczynowski DT, Karsan A. Innate immune signaling in the myelodysplastic syndromes. Hematology/Oncology Clinics of North America. 24: 343-59. PMID 20359630 DOI: 10.1016/j.hoc.2010.02.008  0.4
2010 Starczynowski DT, Karsan A. Deregulation of innate immune signaling in myelodysplastic syndromes is associated with deletion of chromosome arm 5q. Cell Cycle (Georgetown, Tex.). 9: 855-6. PMID 20160505  0.4
2010 Vrljicak P, Chang AC, Morozova O, Wederell ED, Niessen K, Marra MA, Karsan A, Hoodless PA. Genomic analysis distinguishes phases of early development of the mouse atrio-ventricular canal. Physiological Genomics. 40: 150-7. PMID 19952280 DOI: 10.1152/physiolgenomics.00142.2009  0.4
2010 Starczynowski DT, Kuchenbauer F, Argiropoulos B, Sung S, Morin R, Muranyi A, Hirst M, Hogge D, Marra M, Wells RA, Buckstein R, Lam W, Humphries RK, Karsan A. Identification of miR-145 and miR-146a as mediators of the 5q- syndrome phenotype. Nature Medicine. 16: 49-58. PMID 19898489 DOI: 10.1038/nm.2054  0.4
2009 Fu Y, Chang A, Chang L, Niessen K, Eapen S, Setiadi A, Karsan A. Differential regulation of transforming growth factor beta signaling pathways by Notch in human endothelial cells. The Journal of Biological Chemistry. 284: 19452-62. PMID 19473993 DOI: 10.1074/jbc.M109.011833  0.4
2009 Vercauteren SM, Bashashati A, Wu D, Brinkman RR, Eaves C, Eaves A, Karsan A. Reduction in multi-lineage and erythroid progenitors distinguishes myelodysplastic syndromes from non-malignant cytopenias. Leukemia Research. 33: 1636-42. PMID 19414193 DOI: 10.1016/j.leukres.2009.03.019  0.4
2008 Starczynowski DT, Vercauteren S, Telenius A, Sung S, Tohyama K, Brooks-Wilson A, Spinelli JJ, Eaves CJ, Eaves AC, Horsman DE, Lam WL, Karsan A. High-resolution whole genome tiling path array CGH analysis of CD34+ cells from patients with low-risk myelodysplastic syndromes reveals cryptic copy number alterations and predicts overall and leukemia-free survival. Blood. 112: 3412-24. PMID 18663149 DOI: 10.1182/blood-2007-11-122028  0.4
2008 Niessen K, Fu Y, Chang L, Hoodless PA, McFadden D, Karsan A. Slug is a direct Notch target required for initiation of cardiac cushion cellularization. The Journal of Cell Biology. 182: 315-25. PMID 18663143 DOI: 10.1083/jcb.200710067  0.4
2006 Murphy S, Larrivée B, Pollet I, Craig KS, Williams DE, Huang XH, Abbott M, Wong F, Curtis C, Conrads TP, Veenstra T, Puri M, Hsiang Y, Roberge M, Andersen RJ, ... Karsan A, et al. Identification of sokotrasterol sulfate as a novel proangiogenic steroid. Circulation Research. 99: 257-65. PMID 16794189 DOI: 10.1161/01.RES.0000233316.17882.33  0.4
2005 Larrivée B, Niessen K, Pollet I, Corbel SY, Long M, Rossi FM, Olive PL, Karsan A. Minimal contribution of marrow-derived endothelial precursors to tumor vasculature. Journal of Immunology (Baltimore, Md. : 1950). 175: 2890-9. PMID 16116175  0.4
2005 Hood BL, Lucas DA, Kim G, Chan KC, Blonder J, Issaq HJ, Veenstra TD, Conrads TP, Pollet I, Karsan A. Quantitative analysis of the low molecular weight serum proteome using 18O stable isotope labeling in a lung tumor xenograft mouse model. Journal of the American Society For Mass Spectrometry. 16: 1221-30. PMID 15979327 DOI: 10.1016/j.jasms.2005.02.005  0.4
2005 Karsan A, Eigl BJ, Flibotte S, Gelmon K, Switzer P, Hassell P, Harrison D, Law J, Hayes M, Stillwell M, Xiao Z, Conrads TP, Veenstra T. Analytical and preanalytical biases in serum proteomic pattern analysis for breast cancer diagnosis. Clinical Chemistry. 51: 1525-8. PMID 15951319 DOI: 10.1373/clinchem.2005.050708  0.4
2005 Karsan A, Blonder J, Law J, Yaquian E, Lucas DA, Conrads TP, Veenstra T. Proteomic analysis of lipid microdomains from lipopolysaccharide-activated human endothelial cells. Journal of Proteome Research. 4: 349-57. PMID 15822910 DOI: 10.1021/pr049824w  0.4
2005 Karsan A, Pollet I, Yu LR, Chan KC, Conrads TP, Lucas DA, Andersen R, Veenstra T. Quantitative proteomic analysis of sokotrasterol sulfate-stimulated primary human endothelial cells. Molecular & Cellular Proteomics : McP. 4: 191-204. PMID 15611527 DOI: 10.1074/mcp.M400152-MCP200  0.4
2004 Noseda M, Chang L, McLean G, Grim JE, Clurman BE, Smith LL, Karsan A. Notch activation induces endothelial cell cycle arrest and participates in contact inhibition: role of p21Cip1 repression. Molecular and Cellular Biology. 24: 8813-22. PMID 15456857 DOI: 10.1128/MCB.24.20.8813-8822.2004  0.4
2004 MacKenzie F, Duriez P, Larrivée B, Chang L, Pollet I, Wong F, Yip C, Karsan A. Notch4-induced inhibition of endothelial sprouting requires the ankyrin repeats and involves signaling through RBP-Jkappa. Blood. 104: 1760-8. PMID 15187023 DOI: 10.1182/blood-2003-12-4244  0.4
2004 Noseda M, McLean G, Niessen K, Chang L, Pollet I, Montpetit R, Shahidi R, Dorovini-Zis K, Li L, Beckstead B, Durand RE, Hoodless PA, Karsan A. Notch activation results in phenotypic and functional changes consistent with endothelial-to-mesenchymal transformation. Circulation Research. 94: 910-7. PMID 14988227 DOI: 10.1161/01.RES.0000124300.76171.C9  0.4
2003 Harfouche R, Gratton JP, Yancopoulos GD, Noseda M, Karsan A, Hussain SNA. Angiopoietin-1 activates both anti- and proapoptotic mitogen-activated protein kinases The Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 17: 1523-1525. PMID 12824293  0.4
2003 Larrivée B, Lane DR, Pollet I, Olive PL, Humphries RK, Karsan A. Vascular endothelial growth factor receptor-2 induces survival of hematopoietic progenitor cells. The Journal of Biological Chemistry. 278: 22006-13. PMID 12668684 DOI: 10.1074/jbc.M212158200  0.4
1993 Karsan A, Gascoyne RD, Coupland RW, Shepherd JD, Phillips GL, Horsman DE. Combination of t(14;18) and a Burkitt's type translocation in B-cell malignancies. Leukemia & Lymphoma. 10: 433-41. PMID 8401180 DOI: 10.3109/10428199309148200  0.4
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