Christophe Benoist - Publications

Affiliations: 
Harvard University, Cambridge, MA, United States 
Area:
Immunology, Cell Biology

129 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Spallanzani RG, Zemmour D, Xiao T, Jayewickreme T, Li C, Bryce PJ, Benoist C, Mathis D. Distinct immunocyte-promoting and adipocyte-generating stromal components coordinate adipose tissue immune and metabolic tenors. Science Immunology. 4. PMID 31053654 DOI: 10.1126/sciimmunol.aaw3658  0.88
2019 Tuncel J, Benoist C, Mathis D. T cell anergy in perinatal mice is promoted by T reg cells and prevented by IL-33. The Journal of Experimental Medicine. PMID 30988052 DOI: 10.1084/jem.20182002  0.88
2019 Yoshida H, Lareau CA, Ramirez RN, Rose SA, Maier B, Wroblewska A, Desland F, Chudnovskiy A, Mortha A, Dominguez C, Tellier J, Kim E, Dwyer D, Shinton S, Nabekura T, ... ... Benoist C, et al. The cis-Regulatory Atlas of the Mouse Immune System. Cell. PMID 30686579 DOI: 10.1016/j.cell.2018.12.036  0.32
2018 Oh J, Magnuson A, Benoist C, Pittet MJ, Weissleder R. Age-related tumor growth in mice is related to integrin α 4 in CD8+ T cells. Jci Insight. 3. PMID 30385729 DOI: 10.1172/jci.insight.122961  0.36
2018 Magnuson AM, Kiner E, Ergun A, Park JS, Asinovski N, Ortiz-Lopez A, Kilcoyne A, Paoluzzi-Tomada E, Weissleder R, Mathis D, Benoist C. Identification and validation of a tumor-infiltrating Treg transcriptional signature conserved across species and tumor types. Proceedings of the National Academy of Sciences of the United States of America. PMID 30348759 DOI: 10.1073/pnas.1810580115  0.88
2018 DiSpirito JR, Zemmour D, Ramanan D, Cho J, Zilionis R, Klein AM, Benoist C, Mathis D. Molecular diversification of regulatory T cells in nonlymphoid tissues. Science Immunology. 3. PMID 30217811 DOI: 10.1126/sciimmunol.aat5861  0.88
2018 Li C, DiSpirito JR, Zemmour D, Spallanzani RG, Kuswanto W, Benoist C, Mathis D. TCR Transgenic Mice Reveal Stepwise, Multi-site Acquisition of the Distinctive Fat-Treg Phenotype. Cell. PMID 29887374 DOI: 10.1016/j.cell.2018.05.004  0.88
2018 Zemmour D, Zilionis R, Kiner E, Klein AM, Mathis D, Benoist C. Publisher Correction: Single-cell gene expression reveals a landscape of regulatory T cell phenotypes shaped by the TCR. Nature Immunology. PMID 29725080 DOI: 10.1038/s41590-018-0104-4  0.88
2018 Panduro M, Benoist C, Mathis D. Tcells limit IFN-γ production to control macrophage accrual and phenotype during skeletal muscle regeneration. Proceedings of the National Academy of Sciences of the United States of America. PMID 29476012 DOI: 10.1073/pnas.1800618115  0.88
2018 Zemmour D, Zilionis R, Kiner E, Klein AM, Mathis D, Benoist C. Single-cell gene expression reveals a landscape of regulatory T cell phenotypes shaped by the TCR. Nature Immunology. PMID 29434354 DOI: 10.1038/s41590-018-0051-0  0.88
2017 Kwon HK, Chen HM, Mathis D, Benoist C. FoxP3 scanning mutagenesis reveals functional variegation and mild mutations with atypical autoimmune phenotypes. Proceedings of the National Academy of Sciences of the United States of America. PMID 29269391 DOI: 10.1073/pnas.1718599115  0.88
2017 Kwon HK, Chen HM, Mathis D, Benoist C. Different molecular complexes that mediate transcriptional induction and repression by FoxP3. Nature Immunology. PMID 28892470 DOI: 10.1038/ni.3835  0.88
2017 Mohan JF, Kohler RH, Hill JA, Weissleder R, Mathis D, Benoist C. Imaging the emergence and natural progression of spontaneous autoimmune diabetes. Proceedings of the National Academy of Sciences of the United States of America. PMID 28839093 DOI: 10.1073/pnas.1707381114  0.88
2017 Silverman M, Kua L, Tanca A, Pala M, Palomba A, Tanes C, Bittinger K, Uzzau S, Benoist C, Mathis D. Protective major histocompatibility complex allele prevents type 1 diabetes by shaping the intestinal microbiota early in ontogeny. Proceedings of the National Academy of Sciences of the United States of America. PMID 28831005 DOI: 10.1073/pnas.1712280114  0.88
2017 Zemmour D, Pratama A, Loughhead SM, Mathis D, Benoist C. Flicr, a long noncoding RNA, modulates Foxp3 expression and autoimmunity. Proceedings of the National Academy of Sciences of the United States of America. PMID 28396406 DOI: 10.1073/pnas.1700946114  0.88
2017 Yissachar N, Zhou Y, Ung L, Lai NY, Mohan JF, Ehrlicher A, Weitz DA, Kasper DL, Chiu IM, Mathis D, Benoist C. An Intestinal Organ Culture System Uncovers a Role for the Nervous System in Microbe-Immune Crosstalk. Cell. PMID 28262351 DOI: 10.1016/j.cell.2017.02.009  0.88
2017 Glatman Zaretsky A, Konradt C, Dépis F, Wing JB, Goenka R, Atria DG, Silver JS, Cho S, Wolf AI, Quinn WJ, Engiles JB, Brown DC, Beiting D, Erikson J, Allman D, ... ... Benoist CO, et al. T Regulatory Cells Support Plasma Cell Populations in the Bone Marrow. Cell Reports. 18: 1906-1916. PMID 28228257 DOI: 10.1016/j.celrep.2017.01.067  0.36
2017 Geva-Zatorsky N, Sefik E, Kua L, Pasman L, Tan TG, Ortiz-Lopez A, Yanortsang TB, Yang L, Jupp R, Mathis D, Benoist C, Kasper DL. Mining the Human Gut Microbiota for Immunomodulatory Organisms. Cell. PMID 28215708 DOI: 10.1016/j.cell.2017.01.022  0.88
2017 Bansal K, Yoshida H, Benoist C, Mathis D. The transcriptional regulator Aire binds to and activates super-enhancers. Nature Immunology. PMID 28135252 DOI: 10.1038/ni.3675  0.88
2016 Tan TG, Sefik E, Geva-Zatorsky N, Kua L, Naskar D, Teng F, Pasman L, Ortiz-Lopez A, Jupp R, Wu HJ, Kasper DL, Benoist C, Mathis D. Identifying species of symbiont bacteria from the human gut that, alone, can induce intestinal Th17 cells in mice. Proceedings of the National Academy of Sciences of the United States of America. PMID 27911839 DOI: 10.1073/pnas.1617460113  0.88
2016 Tan TG, Mathis D, Benoist C. Singular role for T-BET+CXCR3+ regulatory T cells in protection from autoimmune diabetes. Proceedings of the National Academy of Sciences of the United States of America. PMID 27872297 DOI: 10.1073/pnas.1616710113  0.88
2016 Fujikado N, Mann AO, Bansal K, Romito KR, Ferre EM, Rosenzweig SD, Lionakis MS, Benoist C, Mathis D. Aire Inhibits the Generation of a Perinatal Population of Interleukin-17A-Producing γδ T Cells to Promote Immunologic Tolerance. Immunity. 45: 999-1012. PMID 27851927 DOI: 10.1016/j.immuni.2016.10.023  0.88
2016 Moodley D, Yoshida H, Mostafavi S, Asinovski N, Ortiz-Lopez A, Symanowicz P, Telliez JB, Hegen M, Clark JD, Mathis D, Benoist C. Network pharmacology of JAK inhibitors. Proceedings of the National Academy of Sciences of the United States of America. PMID 27516546 DOI: 10.1073/pnas.1610253113  0.88
2016 Panduro M, Benoist C, Mathis D. Tissue Tregs. Annual Review of Immunology. 34: 609-33. PMID 27168246 DOI: 10.1146/annurev-immunol-032712-095948  0.88
2016 Mathis D, Benoist C. Promiscuity Promotes Tolerance. Journal of Immunology (Baltimore, Md. : 1950). 196: 2913-4. PMID 26994302 DOI: 10.4049/jimmunol.1600225  0.88
2016 Kuswanto W, Burzyn D, Panduro M, Wang KK, Jang YC, Wagers AJ, Benoist C, Mathis D. Poor Repair of Skeletal Muscle in Aging Mice Reflects a Defect in Local, Interleukin-33-Dependent Accumulation of Regulatory T Cells. Immunity. 44: 355-67. PMID 26872699 DOI: 10.1016/j.immuni.2016.01.009  0.88
2016 Singhal G, Fisher FM, Chee MJ, Tan TG, El Ouaamari A, Adams AC, Najarian R, Kulkarni RN, Benoist C, Flier JS, Maratos-Flier E. Fibroblast Growth Factor 21 (FGF21) Protects against High Fat Diet Induced Inflammation and Islet Hyperplasia in Pancreas. Plos One. 11: e0148252. PMID 26872145 DOI: 10.1371/journal.pone.0148252  0.48
2016 Mostafavi S, Yoshida H, Moodley D, LeBoité H, Rothamel K, Raj T, Ye CJ, Chevrier N, Zhang SY, Feng T, Lee M, Casanova JL, Clark JD, Hegen M, Telliez JB, ... ... Benoist C, et al. Parsing the Interferon Transcriptional Network and Its Disease Associations. Cell. 164: 564-578. PMID 26824662 DOI: 10.1016/j.cell.2015.12.032  0.88
2016 Dépis F, Kwon HK, Mathis D, Benoist C. Unstable FoxP3+ T regulatory cells in NZW mice. Proceedings of the National Academy of Sciences of the United States of America. PMID 26768846 DOI: 10.1073/pnas.1524660113  0.88
2015 Yan D, Farache J, Mathis D, Benoist C. Imbalanced signal transduction in regulatory T cells expressing the transcription factor FoxP3. Proceedings of the National Academy of Sciences of the United States of America. 112: 14942-7. PMID 26627244 DOI: 10.1073/pnas.1520393112  0.88
2015 Clardy SM, Mohan JF, Vinegoni C, Keliher EJ, Iwamoto Y, Benoist C, Mathis D, Weissleder R. Rapid, high efficiency isolation of pancreatic ß-cells. Scientific Reports. 5: 13681. PMID 26330153 DOI: 10.1038/srep13681  0.88
2015 Sefik E, Geva-Zatorsky N, Oh S, Konnikova L, Zemmour D, McGuire AM, Burzyn D, Ortiz-Lopez A, Lobera M, Yang J, Ghosh S, Earl A, Snapper SB, Jupp R, Kasper D, ... ... Benoist C, et al. Individual intestinal symbionts induce a distinct population of RORγ+ regulatory T cells. Science (New York, N.Y.). PMID 26272906 DOI: 10.1126/science.aaa9420  0.88
2015 Meredith M, Zemmour D, Mathis D, Benoist C. Aire controls gene expression in the thymic epithelium with ordered stochasticity. Nature Immunology. 16: 942-9. PMID 26237550 DOI: 10.1038/ni.3247  0.88
2015 Yoshida H, Bansal K, Schaefer U, Chapman T, Rioja I, Proekt I, Anderson MS, Prinjha RK, Tarakhovsky A, Benoist C, Mathis D. Brd4 bridges the transcriptional regulators, Aire and P-TEFb, to promote elongation of peripheral-tissue antigen transcripts in thymic stromal cells. Proceedings of the National Academy of Sciences of the United States of America. 112: E4448-57. PMID 26216992 DOI: 10.1073/pnas.1512081112  0.88
2015 Esposito F, Sorosina M, Ottoboni L, Lim ET, Replogle JM, Raj T, Brambilla P, Liberatore G, Guaschino C, Romeo M, Pertel T, Stankiewicz JM, Martinelli V, Rodegher M, Weiner HL, ... ... Benoist C, et al. A pharmacogenetic study implicates SLC9a9 in multiple sclerosis disease activity. Annals of Neurology. 78: 115-27. PMID 25914168 DOI: 10.1002/ana.24429  0.88
2015 Kolodin D, van Panhuys N, Li C, Magnuson AM, Cipolletta D, Miller CM, Wagers A, Germain RN, Benoist C, Mathis D. Antigen- and cytokine-driven accumulation of regulatory T cells in visceral adipose tissue of lean mice. Cell Metabolism. 21: 543-57. PMID 25863247 DOI: 10.1016/j.cmet.2015.03.005  0.88
2015 De Jager PL, Hacohen N, Mathis D, Regev A, Stranger BE, Benoist C. ImmVar project: Insights and design considerations for future studies of "healthy" immune variation. Seminars in Immunology. 27: 51-7. PMID 25819567 DOI: 10.1016/j.smim.2015.03.003  0.88
2015 Yang S, Fujikado N, Kolodin D, Benoist C, Mathis D. Immune tolerance. Regulatory T cells generated early in life play a distinct role in maintaining self-tolerance. Science (New York, N.Y.). 348: 589-94. PMID 25791085 DOI: 10.1126/science.aaa7017  0.88
2015 Gaglia JL, Harisinghani M, Aganj I, Wojtkiewicz GR, Hedgire S, Benoist C, Mathis D, Weissleder R. Noninvasive mapping of pancreatic inflammation in recent-onset type-1 diabetes patients. Proceedings of the National Academy of Sciences of the United States of America. 112: 2139-44. PMID 25650428 DOI: 10.1073/pnas.1424993112  0.88
2015 Magnuson AM, Thurber GM, Kohler RH, Weissleder R, Mathis D, Benoist C. Population dynamics of islet-infiltrating cells in autoimmune diabetes. Proceedings of the National Academy of Sciences of the United States of America. 112: 1511-6. PMID 25605891 DOI: 10.1073/pnas.1423769112  0.88
2015 Cipolletta D, Cohen P, Spiegelman BM, Benoist C, Mathis D. Appearance and disappearance of the mRNA signature characteristic of Treg cells in visceral adipose tissue: age, diet, and PPARγ effects. Proceedings of the National Academy of Sciences of the United States of America. 112: 482-7. PMID 25550516 DOI: 10.1073/pnas.1423486112  0.88
2014 Fu W, Farache J, Clardy SM, Hattori K, Mander P, Lee K, Rioja I, Weissleder R, Prinjha RK, Benoist C, Mathis D. Epigenetic modulation of type-1 diabetes via a dual effect on pancreatic macrophages and β cells. Elife. 3: e04631. PMID 25407682 DOI: 10.7554/eLife.04631  0.88
2014 Mingueneau M, Krishnaswamy S, Spitzer MH, Bendall SC, Stone EL, Hedrick SM, Pe'er D, Mathis D, Nolan GP, Benoist C. Single-cell mass cytometry of TCR signaling: amplification of small initial differences results in low ERK activation in NOD mice. Proceedings of the National Academy of Sciences of the United States of America. 111: 16466-71. PMID 25362052 DOI: 10.1073/pnas.1419337111  0.88
2014 Mostafavi S, Ortiz-Lopez A, Bogue MA, Hattori K, Pop C, Koller D, Mathis D, Benoist C. Variation and genetic control of gene expression in primary immunocytes across inbred mouse strains. Journal of Immunology (Baltimore, Md. : 1950). 193: 4485-96. PMID 25267973 DOI: 10.4049/jimmunol.1401280  0.88
2014 Ye CJ, Feng T, Kwon HK, Raj T, Wilson MT, Asinovski N, McCabe C, Lee MH, Frohlich I, Paik HI, Zaitlen N, Hacohen N, Stranger B, De Jager P, Mathis D, ... ... Benoist C, et al. Intersection of population variation and autoimmunity genetics in human T cell activation. Science (New York, N.Y.). 345: 1254665. PMID 25214635 DOI: 10.1126/science.1254665  0.88
2014 Stangenberg L, Burzyn D, Binstadt BA, Weissleder R, Mahmood U, Benoist C, Mathis D. Denervation protects limbs from inflammatory arthritis via an impact on the microvasculature. Proceedings of the National Academy of Sciences of the United States of America. 111: 11419-24. PMID 25049388 DOI: 10.1073/pnas.1410854111  0.88
2014 Raj T, Rothamel K, Mostafavi S, Ye C, Lee MN, Replogle JM, Feng T, Lee M, Asinovski N, Frohlich I, Imboywa S, Von Korff A, Okada Y, Patsopoulos NA, Davis S, ... ... Benoist C, et al. Polarization of the effects of autoimmune and neurodegenerative risk alleles in leukocytes. Science (New York, N.Y.). 344: 519-23. PMID 24786080 DOI: 10.1126/science.1249547  0.88
2014 Morton AM, Sefik E, Upadhyay R, Weissleder R, Benoist C, Mathis D. Endoscopic photoconversion reveals unexpectedly broad leukocyte trafficking to and from the gut. Proceedings of the National Academy of Sciences of the United States of America. 111: 6696-701. PMID 24753589 DOI: 10.1073/pnas.1405634111  0.88
2014 Joller N, Lozano E, Burkett PR, Patel B, Xiao S, Zhu C, Xia J, Tan TG, Sefik E, Yajnik V, Sharpe AH, Quintana FJ, Mathis D, Benoist C, Hafler DA, et al. Treg cells expressing the coinhibitory molecule TIGIT selectively inhibit proinflammatory Th1 and Th17 cell responses. Immunity. 40: 569-81. PMID 24745333 DOI: 10.1016/j.immuni.2014.02.012  0.88
2014 Ferraro A, D'Alise AM, Raj T, Asinovski N, Phillips R, Ergun A, Replogle JM, Bernier A, Laffel L, Stranger BE, De Jager PL, Mathis D, Benoist C. Interindividual variation in human T regulatory cells. Proceedings of the National Academy of Sciences of the United States of America. 111: E1111-20. PMID 24610777 DOI: 10.1073/pnas.1401343111  0.88
2014 Lee MN, Ye C, Villani AC, Raj T, Li W, Eisenhaure TM, Imboywa SH, Chipendo PI, Ran FA, Slowikowski K, Ward LD, Raddassi K, McCabe C, Lee MH, Frohlich IY, ... ... Benoist CO, et al. Common genetic variants modulate pathogen-sensing responses in human dendritic cells. Science (New York, N.Y.). 343: 1246980. PMID 24604203 DOI: 10.1126/science.1246980  0.88
2014 Giraud M, Jmari N, Du L, Carallis F, Nieland TJ, Perez-Campo FM, Bensaude O, Root DE, Hacohen N, Mathis D, Benoist C. An RNAi screen for Aire cofactors reveals a role for Hnrnpl in polymerase release and Aire-activated ectopic transcription. Proceedings of the National Academy of Sciences of the United States of America. 111: 1491-6. PMID 24434558 DOI: 10.1073/pnas.1323535111  0.88
2014 Clardy SM, Keliher EJ, Mohan JF, Sebas M, Benoist C, Mathis D, Weissleder R. Fluorescent exendin-4 derivatives for pancreatic β-cell analysis. Bioconjugate Chemistry. 25: 171-7. PMID 24328216 DOI: 10.1021/bc4005014  0.88
2013 Burzyn D, Kuswanto W, Kolodin D, Shadrach JL, Cerletti M, Jang Y, Sefik E, Tan TG, Wagers AJ, Benoist C, Mathis D. A special population of regulatory T cells potentiates muscle repair. Cell. 155: 1282-95. PMID 24315098 DOI: 10.1016/j.cell.2013.10.054  0.88
2013 Burzyn D, Benoist C, Mathis D. Regulatory T cells in nonlymphoid tissues. Nature Immunology. 14: 1007-13. PMID 24048122 DOI: 10.1038/ni.2683  0.88
2013 Li L, Nishio J, van Maurik A, Mathis D, Benoist C. Differential response of regulatory and conventional CD4⁺ lymphocytes to CD3 engagement: clues to a possible mechanism of anti-CD3 action? Journal of Immunology (Baltimore, Md. : 1950). 191: 3694-704. PMID 23986534 DOI: 10.4049/jimmunol.1300408  0.88
2013 Ergun A, Doran G, Costello JC, Paik HH, Collins JJ, Mathis D, Benoist C. Differential splicing across immune system lineages. Proceedings of the National Academy of Sciences of the United States of America. 110: 14324-9. PMID 23934048 DOI: 10.1073/pnas.1311839110  0.88
2013 Sitrin J, Ring A, Garcia KC, Benoist C, Mathis D. Regulatory T cells control NK cells in an insulitic lesion by depriving them of IL-2. The Journal of Experimental Medicine. 210: 1153-65. PMID 23650440 DOI: 10.1084/jem.20122248  0.88
2013 Mingueneau M, Kreslavsky T, Gray D, Heng T, Cruse R, Ericson J, Bendall S, Spitzer MH, Nolan GP, Kobayashi K, von Boehmer H, Mathis D, Benoist C, Best AJ, ... ... Benoist C, et al. The transcriptional landscape of αβ T cell differentiation. Nature Immunology. 14: 619-32. PMID 23644507 DOI: 10.1038/ni.2590  0.88
2013 Jojic V, Shay T, Sylvia K, Zuk O, Sun X, Kang J, Regev A, Koller D, Best AJ, Knell J, Goldrath A, Joic V, Koller D, Shay T, ... ... Benoist C, et al. Identification of transcriptional regulators in the mouse immune system. Nature Immunology. 14: 633-43. PMID 23624555 DOI: 10.1038/ni.2587  0.88
2013 Abbas AK, Benoist C, Bluestone JA, Campbell DJ, Ghosh S, Hori S, Jiang S, Kuchroo VK, Mathis D, Roncarolo MG, Rudensky A, Sakaguchi S, Shevach EM, Vignali DA, Ziegler SF. Regulatory T cells: recommendations to simplify the nomenclature. Nature Immunology. 14: 307-8. PMID 23507634 DOI: 10.1038/ni.2554  0.88
2013 Shay T, Jojic V, Zuk O, Rothamel K, Puyraimond-Zemmour D, Feng T, Wakamatsu E, Benoist C, Koller D, Regev A. Conservation and divergence in the transcriptional programs of the human and mouse immune systems Proceedings of the National Academy of Sciences of the United States of America. 110: 2946-2951. PMID 23382184 DOI: 10.1073/pnas.1222738110  0.88
2013 Yang S, Bansal K, Lopes J, Benoist C, Mathis D. Aire's plant homeodomain(PHD)-2 is critical for induction of immunological tolerance. Proceedings of the National Academy of Sciences of the United States of America. 110: 1833-8. PMID 23319629 DOI: 10.1073/pnas.1222023110  0.88
2013 Wakamatsu E, Mathis D, Benoist C. Convergent and divergent effects of costimulatory molecules in conventional and regulatory CD4+ T cells. Proceedings of the National Academy of Sciences of the United States of America. 110: 1023-8. PMID 23277554 DOI: 10.1073/pnas.1220688110  0.88
2012 Shu CJ, Benoist C, Mathis D. The immune system's involvement in obesity-driven type 2 diabetes. Seminars in Immunology. 24: 436-42. PMID 23333525 DOI: 10.1016/j.smim.2012.12.001  0.88
2012 Donner Y, Feng T, Benoist C, Koller D. Imputing gene expression from selectively reduced probe sets Nature Methods. 9: 1120-1125. PMID 23064520 DOI: 10.1038/nmeth.2207  0.88
2012 Lim AS, Chang AM, Shulman JM, Raj T, Chibnik LB, Cain SW, Rothamel K, Benoist C, Myers AJ, Czeisler CA, Buchman AS, Bennett DA, Duffy JF, Saper CB, De Jager PL. A common polymorphism near PER1 and the timing of human behavioral rhythms. Annals of Neurology. 72: 324-34. PMID 23034908 DOI: 10.1002/ana.23636  0.88
2012 Fu W, Ergun A, Lu T, Hill JA, Haxhinasto S, Fassett MS, Gazit R, Adoro S, Glimcher L, Chan S, Kastner P, Rossi D, Collins JJ, Mathis D, Benoist C. A multiply redundant genetic switch 'locks in' the transcriptional signature of regulatory T cells. Nature Immunology. 13: 972-80. PMID 22961053 DOI: 10.1038/ni.2420  0.88
2012 Benoist C, Lanier L, Merad M, Mathis D. Consortium biology in immunology: the perspective from the Immunological Genome Project. Nature Reviews. Immunology. 12: 734-40. PMID 22955842 DOI: 10.1038/nri3300  0.88
2012 Benoist C, Mathis D. Treg cells, life history, and diversity. Cold Spring Harbor Perspectives in Biology. 4: a007021. PMID 22952391 DOI: 10.1101/cshperspect.a007021  0.88
2012 Chung H, Pamp SJ, Hill JA, Surana NK, Edelman SM, Troy EB, Reading NC, Villablanca EJ, Wang S, Mora JR, Umesaki Y, Mathis D, Benoist C, Relman DA, Kasper DL. Gut immune maturation depends on colonization with a host-specific microbiota. Cell. 149: 1578-93. PMID 22726443 DOI: 10.1016/j.cell.2012.04.037  0.88
2012 Cipolletta D, Feuerer M, Li A, Kamei N, Lee J, Shoelson SE, Benoist C, Mathis D. PPAR-γ is a major driver of the accumulation and phenotype of adipose tissue Treg cells. Nature. 486: 549-53. PMID 22722857 DOI: 10.1038/nature11132  0.88
2012 Darce J, Rudra D, Li L, Nishio J, Cipolletta D, Rudensky AY, Mathis D, Benoist C. An N-terminal mutation of the Foxp3 transcription factor alleviates arthritis but exacerbates diabetes. Immunity. 36: 731-41. PMID 22579475 DOI: 10.1016/j.immuni.2012.04.007  0.88
2012 Fu W, Wojtkiewicz G, Weissleder R, Benoist C, Mathis D. Early window of diabetes determinism in NOD mice, dependent on the complement receptor CRIg, identified by noninvasive imaging. Nature Immunology. 13: 361-8. PMID 22366893 DOI: 10.1038/ni.2233  0.88
2012 Fassett MS, Jiang W, D'Alise AM, Mathis D, Benoist C. Nuclear receptor Nr4a1 modulates both regulatory T-cell (Treg) differentiation and clonal deletion. Proceedings of the National Academy of Sciences of the United States of America. 109: 3891-6. PMID 22345564 DOI: 10.1073/pnas.1200090109  0.88
2012 Mingueneau M, Jiang W, Feuerer M, Mathis D, Benoist C. Thymic negative selection is functional in NOD mice. The Journal of Experimental Medicine. 209: 623-37. PMID 22329992 DOI: 10.1084/jem.20112593  0.88
2012 Rao SM, Auger JL, Gaillard P, Weissleder R, Wada E, Torres R, Kojima M, Benoist C, Mathis D, Binstadt BA. The neuropeptide neuromedin U promotes autoantibody-mediated arthritis. Arthritis Research & Therapy. 14: R29. PMID 22314006 DOI: 10.1186/ar3732  0.88
2012 Giraud M, Yoshida H, Abramson J, Rahl PB, Young RA, Mathis D, Benoist C. Aire unleashes stalled RNA polymerase to induce ectopic gene expression in thymic epithelial cells. Proceedings of the National Academy of Sciences of the United States of America. 109: 535-40. PMID 22203960 DOI: 10.1073/pnas.1119351109  0.88
2012 Mathis D, Benoist C. The influence of the microbiota on type-1 diabetes: on the threshold of a leap forward in our understanding. Immunological Reviews. 245: 239-49. PMID 22168424 DOI: 10.1111/j.1600-065X.2011.01084.x  0.88
2011 Feyerabend TB, Weiser A, Tietz A, Stassen M, Harris N, Kopf M, Radermacher P, Möller P, Benoist C, Mathis D, Fehling HJ, Rodewald HR. Cre-mediated cell ablation contests mast cell contribution in models of antibody- and T cell-mediated autoimmunity. Immunity. 35: 832-44. PMID 22101159 DOI: 10.1016/j.immuni.2011.09.015  0.88
2011 Mathis D, Benoist C. Microbiota and autoimmune disease: the hosted self. Cell Host & Microbe. 10: 297-301. PMID 22018229 DOI: 10.1016/j.chom.2011.09.007  0.88
2011 Reiner T, Thurber G, Gaglia J, Vinegoni C, Liew CW, Upadhyay R, Kohler RH, Li L, Kulkarni RN, Benoist C, Mathis D, Weissleder R. Accurate measurement of pancreatic islet beta-cell mass using a second-generation fluorescent exendin-4 analog. Proceedings of the National Academy of Sciences of the United States of America. 108: 12815-20. PMID 21768367 DOI: 10.1073/pnas.1109859108  0.88
2011 Cipolletta D, Kolodin D, Benoist C, Mathis D. Tissular T(regs): a unique population of adipose-tissue-resident Foxp3+CD4+ T cells that impacts organismal metabolism. Seminars in Immunology. 23: 431-7. PMID 21724410 DOI: 10.1016/j.smim.2011.06.002  0.88
2011 Kriegel MA, Sefik E, Hill JA, Wu HJ, Benoist C, Mathis D. Naturally transmitted segmented filamentous bacteria segregate with diabetes protection in nonobese diabetic mice. Proceedings of the National Academy of Sciences of the United States of America. 108: 11548-53. PMID 21709219 DOI: 10.1073/pnas.1108924108  0.88
2011 Johnsen AK, Valdar W, Golden L, Ortiz-Lopez A, Hitzemann R, Flint J, Mathis D, Benoist C. Genome-wide and species-wide dissection of the genetics of arthritis severity in heterogeneous stock mice. Arthritis and Rheumatism. 63: 2630-40. PMID 21560115 DOI: 10.1002/art.30425  0.88
2011 Benoist C, Hacohen N. Flow cytometry, amped up Science. 332: 677-678. PMID 21551055 DOI: 10.1126/science.1206351  0.88
2011 D'Alise AM, Ergun A, Hill JA, Mathis D, Benoist C. A cluster of coregulated genes determines TGF-beta-induced regulatory T-cell (Treg) dysfunction in NOD mice. Proceedings of the National Academy of Sciences of the United States of America. 108: 8737-42. PMID 21543717 DOI: 10.1073/pnas.1105364108  0.88
2011 Bandukwala HS, Wu Y, Feuerer M, Chen Y, Barboza B, Ghosh S, Stroud JC, Benoist C, Mathis D, Rao A, Chen L. Structure of a domain-swapped FOXP3 dimer on DNA and its function in regulatory T cells. Immunity. 34: 479-91. PMID 21458306 DOI: 10.1016/j.immuni.2011.02.017  0.88
2011 Painter MW, Davis S, Hardy RR, Mathis D, Benoist C. Transcriptomes of the B and T lineages compared by multiplatform microarray profiling. Journal of Immunology (Baltimore, Md. : 1950). 186: 3047-57. PMID 21307297 DOI: 10.4049/jimmunol.1002695  0.88
2011 Gaglia JL, Guimaraes AR, Harisinghani M, Turvey SE, Jackson R, Benoist C, Mathis D, Weissleder R. Noninvasive imaging of pancreatic islet inflammation in type 1A diabetes patients. The Journal of Clinical Investigation. 121: 442-5. PMID 21123946 DOI: 10.1172/JCI44339  0.88
2010 Huang GJ, Smith AL, Gray DH, Cosgrove C, Singer BH, Edwards A, Sims S, Sim S, Parent JM, Johnsen A, Mott R, Mathis D, Klenerman P, Benoist C, Flint J. A genetic and functional relationship between T cells and cellular proliferation in the adult hippocampus. Plos Biology. 8: e1000561. PMID 21179499 DOI: 10.1371/journal.pbio.1000561  0.88
2010 Rubtsov YP, Niec RE, Josefowicz S, Li L, Darce J, Mathis D, Benoist C, Rudensky AY. Stability of the regulatory T cell lineage in vivo. Science (New York, N.Y.). 329: 1667-71. PMID 20929851 DOI: 10.1126/science.1191996  0.88
2010 Yalcin B, Nicod J, Bhomra A, Davidson S, Cleak J, Farinelli L, ØsterÃ¥s M, Whitley A, Yuan W, Gan X, Goodson M, Klenerman P, Satpathy A, Mathis D, Benoist C, et al. Commercially available outbred mice for genome-wide association studies. Plos Genetics. 6: e1001085. PMID 20838427 DOI: 10.1371/journal.pgen.1001085  0.88
2010 Nishio J, Feuerer M, Wong J, Mathis D, Benoist C. Anti-CD3 therapy permits regulatory T cells to surmount T cell receptor-specified peripheral niche constraints. The Journal of Experimental Medicine. 207: 1879-89. PMID 20679403 DOI: 10.1084/jem.20100205  0.88
2010 Wu HJ, Ivanov II, Darce J, Hattori K, Shima T, Umesaki Y, Littman DR, Benoist C, Mathis D. Gut-residing segmented filamentous bacteria drive autoimmune arthritis via T helper 17 cells. Immunity. 32: 815-27. PMID 20620945 DOI: 10.1016/j.immuni.2010.06.001  0.88
2010 Koh AS, Kingston RE, Benoist C, Mathis D. Global relevance of Aire binding to hypomethylated lysine-4 of histone-3. Proceedings of the National Academy of Sciences of the United States of America. 107: 13016-21. PMID 20615959 DOI: 10.1073/pnas.1004436107  0.88
2010 Jacobs JP, Ortiz-Lopez A, Campbell JJ, Gerard CJ, Mathis D, Benoist C. Deficiency of CXCR2, but not other chemokine receptors, attenuates autoantibody-mediated arthritis in a murine model. Arthritis and Rheumatism. 62: 1921-32. PMID 20506316 DOI: 10.1002/art.27470  0.88
2010 Suwanai H, Wilcox MA, Mathis D, Benoist C. A defective Il15 allele underlies the deficiency in natural killer cell activity in nonobese diabetic mice. Proceedings of the National Academy of Sciences of the United States of America. 107: 9305-10. PMID 20439722 DOI: 10.1073/pnas.1004492107  0.88
2010 Iwai LK, Benoist C, Mathis D, White FM. Quantitative phosphoproteomic analysis of T cell receptor signaling in diabetes prone and resistant mice. Journal of Proteome Research. 9: 3135-45. PMID 20438120 DOI: 10.1021/pr100035b  0.88
2010 Feuerer M, Hill JA, Kretschmer K, von Boehmer H, Mathis D, Benoist C. Genomic definition of multiple ex vivo regulatory T cell subphenotypes. Proceedings of the National Academy of Sciences of the United States of America. 107: 5919-24. PMID 20231436 DOI: 10.1073/pnas.1002006107  0.88
2010 Monach PA, Nigrovic PA, Chen M, Hock H, Lee DM, Benoist C, Mathis D. Neutrophils in a mouse model of autoantibody-mediated arthritis: critical producers of Fc receptor gamma, the receptor for C5a, and lymphocyte function-associated antigen 1. Arthritis and Rheumatism. 62: 753-64. PMID 20191628 DOI: 10.1002/art.27238  0.88
2010 Huang H, Benoist C, Mathis D. Rituximab specifically depletes short-lived autoreactive plasma cells in a mouse model of inflammatory arthritis. Proceedings of the National Academy of Sciences of the United States of America. 107: 4658-63. PMID 20176942 DOI: 10.1073/pnas.1001074107  0.88
2010 Abramson J, Giraud M, Benoist C, Mathis D. Aire's partners in the molecular control of immunological tolerance. Cell. 140: 123-35. PMID 20085707 DOI: 10.1016/j.cell.2009.12.030  0.88
2010 Mathis D, Benoist C. Levees of immunological tolerance. Nature Immunology. 11: 3-6. PMID 20016503 DOI: 10.1038/ni.1833  0.88
2009 Jacobs JP, Wu HJ, Benoist C, Mathis D. IL-17-producing T cells can augment autoantibody-induced arthritis. Proceedings of the National Academy of Sciences of the United States of America. 106: 21789-94. PMID 19955422 DOI: 10.1073/pnas.0912152106  0.88
2009 Feuerer M, Shen Y, Littman DR, Benoist C, Mathis D. How punctual ablation of regulatory T cells unleashes an autoimmune lesion within the pancreatic islets. Immunity. 31: 654-64. PMID 19818653 DOI: 10.1016/j.immuni.2009.08.023  0.88
2009 Monach PA, Hueber W, Kessler B, Tomooka BH, BenBarak M, Simmons BP, Wright J, Thornhill TS, Monestier M, Ploegh H, Robinson WH, Mathis D, Benoist C. A broad screen for targets of immune complexes decorating arthritic joints highlights deposition of nucleosomes in rheumatoid arthritis. Proceedings of the National Academy of Sciences of the United States of America. 106: 15867-72. PMID 19720992 DOI: 10.1073/pnas.0908032106  0.88
2009 Stangenberg L, Ellson C, Cortez-Retamozo V, Ortiz-Lopez A, Yuan H, Blois J, Smith RA, Yaffe MB, Weissleder R, Benoist C, Mathis D, Josephson L, Mahmood U. Abrogation of antibody-induced arthritis in mice by a self-activating viridin prodrug and association with impaired neutrophil and endothelial cell function. Arthritis and Rheumatism. 60: 2314-24. PMID 19644878 DOI: 10.1002/art.24704  0.88
2009 Feuerer M, Herrero L, Cipolletta D, Naaz A, Wong J, Nayer A, Lee J, Goldfine AB, Benoist C, Shoelson S, Mathis D. Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters. Nature Medicine. 15: 930-9. PMID 19633656 DOI: 10.1038/nm.2002  0.88
2009 Feuerer M, Hill JA, Mathis D, Benoist C. Foxp3+ regulatory T cells: differentiation, specification, subphenotypes. Nature Immunology. 10: 689-95. PMID 19536194 DOI: 10.1038/ni.1760  0.88
2009 Guerau-de-Arellano M, Martinic M, Benoist C, Mathis D. Neonatal tolerance revisited: a perinatal window for Aire control of autoimmunity. The Journal of Experimental Medicine. 206: 1245-52. PMID 19487417 DOI: 10.1084/jem.20090300  0.88
2009 Mathis D, Benoist C. Aire. Annual Review of Immunology. 27: 287-312. PMID 19302042 DOI: 10.1146/annurev.immunol.25.022106.141532  0.88
2008 D'Alise AM, Auyeung V, Feuerer M, Nishio J, Fontenot J, Benoist C, Mathis D. The defect in T-cell regulation in NOD mice is an effect on the T-cell effectors. Proceedings of the National Academy of Sciences of the United States of America. 105: 19857-62. PMID 19073938 DOI: 10.1073/pnas.0810713105  0.88
2008 Hill JA, Hall JA, Sun CM, Cai Q, Ghyselinck N, Chambon P, Belkaid Y, Mathis D, Benoist C. Retinoic acid enhances Foxp3 induction indirectly by relieving inhibition from CD4+CD44hi Cells. Immunity. 29: 758-70. PMID 19006694 DOI: 10.1016/j.immuni.2008.09.018  0.88
2008 Nigrovic PA, Gray DH, Jones T, Hallgren J, Kuo FC, Chaletzky B, Gurish M, Mathis D, Benoist C, Lee DM. Genetic inversion in mast cell-deficient (Wsh) mice interrupts corin and manifests as hematopoietic and cardiac aberrancy. The American Journal of Pathology. 173: 1693-701. PMID 18988802 DOI: 10.2353/ajpath.2008.080407  0.88
2008 Koh AS, Kuo AJ, Park SY, Cheung P, Abramson J, Bua D, Carney D, Shoelson SE, Gozani O, Kingston RE, Benoist C, Mathis D. Aire employs a histone-binding module to mediate immunological tolerance, linking chromatin regulation with organ-specific autoimmunity. Proceedings of the National Academy of Sciences of the United States of America. 105: 15878-83. PMID 18840680 DOI: 10.1073/pnas.0808470105  0.88
2008 Venanzi ES, Melamed R, Mathis D, Benoist C. The variable immunological self: genetic variation and nongenetic noise in Aire-regulated transcription. Proceedings of the National Academy of Sciences of the United States of America. 105: 15860-5. PMID 18838677 DOI: 10.1073/pnas.0808070105  0.88
2008 Villaseñor J, Besse W, Benoist C, Mathis D. Ectopic expression of peripheral-tissue antigens in the thymic epithelium: probabilistic, monoallelic, misinitiated. Proceedings of the National Academy of Sciences of the United States of America. 105: 15854-9. PMID 18836079 DOI: 10.1073/pnas.0808069105  0.88
2008 Guerau-de-Arellano M, Mathis D, Benoist C. Transcriptional impact of Aire varies with cell type. Proceedings of the National Academy of Sciences of the United States of America. 105: 14011-6. PMID 18780794 DOI: 10.1073/pnas.0806616105  0.88
2008 Gavanescu I, Benoist C, Mathis D. B cells are required for Aire-deficient mice to develop multi-organ autoinflammation: A therapeutic approach for APECED patients. Proceedings of the National Academy of Sciences of the United States of America. 105: 13009-14. PMID 18755889 DOI: 10.1073/pnas.0806874105  0.88
2008 Johnsen AK, Plenge RM, Butty V, Campbell C, Dieguez-Gonzalez R, Gomez-Reino JJ, Shadick N, Weinblatt M, Gonzalez A, Gregersen PK, Benoist C, Mathis D. A broad analysis of IL1 polymorphism and rheumatoid arthritis. Arthritis and Rheumatism. 58: 1947-57. PMID 18576312 DOI: 10.1002/art.23592  0.88
2008 Butty V, Campbell C, Mathis D, Benoist C. Impact of diabetes susceptibility loci on progression from pre-diabetes to diabetes in at-risk individuals of the diabetes prevention trial-type 1 (DPT-1). Diabetes. 57: 2348-59. PMID 18556337 DOI: 10.2337/db07-1736  0.88
2008 Monach PA, Mathis D, Benoist C. The K/BxN arthritis model. Current Protocols in Immunology / Edited by John E. Coligan ... [Et Al.]. Unit 15.22. PMID 18491295 DOI: 10.1002/0471142735.im1522s81  0.88
2007 Venanzi ES, Gray DH, Benoist C, Mathis D. Lymphotoxin pathway and Aire influences on thymic medullary epithelial cells are unconnected. Journal of Immunology (Baltimore, Md. : 1950). 179: 5693-700. PMID 17947641  0.88
2005 Anderson MS, Venanzi ES, Chen Z, Berzins SP, Benoist C, Mathis D. The cellular mechanism of Aire control of T cell tolerance. Immunity. 23: 227-39. PMID 16111640 DOI: 10.1016/j.immuni.2005.07.005  0.88
2005 Johnnidis JB, Venanzi ES, Taxman DJ, Ting JP, Benoist CO, Mathis DJ. Chromosomal clustering of genes controlled by the aire transcription factor. Proceedings of the National Academy of Sciences of the United States of America. 102: 7233-8. PMID 15883360 DOI: 10.1073/pnas.0502670102  0.96
2004 Venanzi ES, Benoist C, Mathis D. Good riddance: Thymocyte clonal deletion prevents autoimmunity. Current Opinion in Immunology. 16: 197-202. PMID 15023413 DOI: 10.1016/j.coi.2004.01.008  0.96
2003 Berzins SP, Venanzi ES, Benoist C, Mathis D. T-cell compartments of prediabetic NOD mice. Diabetes. 52: 327-34. PMID 12540604  0.96
2002 Anderson MS, Venanzi ES, Klein L, Chen Z, Berzins SP, Turley SJ, von Boehmer H, Bronson R, Dierich A, Benoist C, Mathis D. Projection of an immunological self shadow within the thymus by the aire protein. Science (New York, N.Y.). 298: 1395-401. PMID 12376594 DOI: 10.1126/science.1075958  0.88
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