Zhiming Zhang, M.D./Ph.D. - Publications

Affiliations: 
Anatomy & Physiology University of Kentucky, Lexington, KY 

52 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Quintero JE, Ai Y, Andersen AH, Hardy P, Grondin R, Guduru Z, Gash DM, Gerhardt GA, Zhang Z. Validations of apomorphine-induced BOLD activation correlations in hemiparkinsonian rhesus macaques. Neuroimage. Clinical. 22: 101724. PMID 30822717 DOI: 10.1016/J.Nicl.2019.101724  0.409
2018 Grondin R, Littrell OM, Zhang Z, Ai Y, Huettl P, Pomerleau F, Quintero JE, Andersen AH, Stenslik MJ, Bradley LH, Lemmon J, O'Neill MJ, Gash DM, Gerhardt GA. GDNF revisited: A novel mammalian cell-derived variant form of GDNF increases dopamine turnover and improves brain biodistribution. Neuropharmacology. PMID 29857941 DOI: 10.1016/J.Neuropharm.2018.05.014  0.413
2018 Stenslik MJ, Evans A, Pomerleau F, Weeks R, Huettl P, Foreman E, Turchan-Cholewo J, Andersen A, Cass WA, Zhang Z, Grondin RC, Gash DM, Gerhardt GA, Bradley LH. Methodology and effects of repeated intranasal delivery of DNSP-11 in awake Rhesus macaques. Journal of Neuroscience Methods. PMID 29614295 DOI: 10.1016/J.Jneumeth.2018.03.006  0.321
2017 Zhang R, Andersen AH, Hardy PA, Forman E, Evans A, Ai Y, Yue J, Yue G, Gash DM, Grondin R, Zhang Z. Objectively measuring effects of electro-acupuncture in parkinsonian rhesus monkeys. Brain Research. PMID 29017909 DOI: 10.1016/J.Brainres.2017.10.006  0.394
2016 Grondin R, Ai Y, Hardy PA, Butt MT, Nelson BD, Lemmon JD, Bumcrot D, Gash DM, Gerhardt GA, Zhang Z. Continuous intranigral infusion is not associated with observable behavioral deficits or marked pathology: a preclinical safety study. Journal of Neurosurgery. 1-10. PMID 27231974 DOI: 10.3171/2016.2.Jns152295  0.353
2015 Grondin R, Ge P, Chen Q, Sutherland JE, Zhang Z, Gash DM, Stiles DK, Stewart GR, Sah DW, Kaemmerer WF. Onset Time and Durability of Huntingtin Suppression in Rhesus Putamen After Direct Infusion of Antihuntingtin siRNA. Molecular Therapy. Nucleic Acids. 4: e245. PMID 26125484 DOI: 10.1038/Mtna.2015.20  0.31
2015 Pandya JD, Grondin R, Yonutas HM, Haghnazar H, Gash DM, Zhang Z, Sullivan PG. Decreased mitochondrial bioenergetics and calcium buffering capacity in the basal ganglia correlates with motor deficits in a nonhuman primate model of aging. Neurobiology of Aging. 36: 1903-13. PMID 25726361 DOI: 10.1016/J.Neurobiolaging.2015.01.018  0.33
2015 Andersen AH, Hardy PA, Forman E, Gerhardt GA, Gash DM, Grondin RC, Zhang Z. Pharmacologic MRI (phMRI) as a tool to differentiate Parkinson's disease-related from age-related changes in basal ganglia function. Neurobiology of Aging. 36: 1174-82. PMID 25443764 DOI: 10.1016/J.Neurobiolaging.2014.10.014  0.393
2014 Fan XT, Zhao F, Ai Y, Andersen A, Hardy P, Ling F, Gerhardt GA, Zhang Z, Quintero JE. Cortical glutamate levels decrease in a non-human primate model of dopamine deficiency. Brain Research. 1552: 34-40. PMID 24398457 DOI: 10.1016/J.Brainres.2013.12.035  0.366
2012 Leak RK, Garbett KA, Dettmer AM, Zhang Z, Mirnics K, Cameron JL. Physical activity is linked to ceruloplasmin in the striatum of intact but not MPTP-treated primates. Cell and Tissue Research. 350: 401-7. PMID 22940761 DOI: 10.1007/S00441-012-1488-3  0.682
2012 Stiles DK, Zhang Z, Ge P, Nelson B, Grondin R, Ai Y, Hardy P, Nelson PT, Guzaev AP, Butt MT, Charisse K, Kosovrasti V, Tchangov L, Meys M, Maier M, et al. Widespread suppression of huntingtin with convection-enhanced delivery of siRNA. Experimental Neurology. 233: 463-71. PMID 22119622 DOI: 10.1016/J.Expneurol.2011.11.020  0.343
2012 Zhang Z, Andersen A, Hardy P, Ai Y, Grondin R, Gash D, Gerhardt G. 2.150 A POSSIBLE NEW BIOMARKER FOR PARKINSON'S DISEASE: PHARMACOLOGICAL MRI (PHMRI) TO DISCRIMINATE ANIMALS WITH MPTP-VERSUS AGE-RELATED PARKINSONISM IN RHESUS MONKEYS Parkinsonism & Related Disorders. 18: S114. DOI: 10.1016/S1353-8020(11)70522-3  0.371
2010 Zhao F, Fan X, Grondin R, Edwards R, Forman E, Moorehead J, Gerhardt G, Wang X, Zhang Z. Improved methods for electroacupuncture and electromyographic recordings in normal and parkinsonian rhesus monkeys. Journal of Neuroscience Methods. 192: 199-206. PMID 20654649 DOI: 10.1016/J.Jneumeth.2010.07.016  0.351
2010 Bradley LH, Fuqua J, Richardson A, Turchan-Cholewo J, Ai Y, Kelps KA, Glass JD, He X, Zhang Z, Grondin R, Littrell OM, Huettl P, Pomerleau F, Gash DM, Gerhardt GA. Dopamine neuron stimulating actions of a GDNF propeptide. Plos One. 5: e9752. PMID 20305789 DOI: 10.1371/Journal.Pone.0009752  0.404
2010 Lopresti BJ, Dettmar A, Leak R, Rockcastle NJ, Zigmond MJ, Mathis C, Zhang Z, Cameron J. Regular exercise training protects against MPTP-damage to nigrostriatal dopamine neurons in nonhuman primates Neuroimage. 52: S66. DOI: 10.1016/J.Neuroimage.2010.04.051  0.537
2008 Ding F, Luan L, Ai Y, Walton A, Gerhardt GA, Gash DM, Grondin R, Zhang Z. Development of a stable, early stage unilateral model of Parkinson's disease in middle-aged rhesus monkeys. Experimental Neurology. 212: 431-9. PMID 18547564 DOI: 10.1016/J.Expneurol.2008.04.027  0.383
2008 Luan L, Ding F, Ai Y, Andersen A, Hardy P, Forman E, Gerhardt GA, Gash DM, Grondin R, Zhang Z. Pharmacological MRI (phMRI) monitoring of treatment in hemiparkinsonian rhesus monkeys. Cell Transplantation. 17: 417-25. PMID 18522244 DOI: 10.3727/096368908784423319  0.391
2008 Xin T, Ai Y, Gerhardt G, Gash D, Zhang Z. Globus pallidus plays a critical role in neurotrophic factor induced functional improvements in hemiparkinsonian monkeys. Biochemical and Biophysical Research Communications. 370: 434-9. PMID 18381061 DOI: 10.1016/J.Bbrc.2008.03.108  0.354
2008 Grondin R, Zhang Z, Ai Y, Ding F, Walton AA, Surgener SP, Gerhardt GA, Gash DM. Intraputamenal infusion of exogenous neurturin protein restores motor and dopaminergic function in the globus pallidus of MPTP-lesioned rhesus monkeys. Cell Transplantation. 17: 373-381. DOI: 10.3727/096368908784423256  0.373
2008 Lopresti BJ, Zhang Z, Zigmond M, Leak R, Mathis C, Cameron J. Increased survival of nigrostriatal dopaminergic neurons following a toxic MPTP insult in the exercising primate: A [11C]DTBZ PET study Neuroimage. 41: T55. DOI: 10.1016/J.Neuroimage.2008.04.229  0.528
2008 Leak RK, Zhang Z, Castro S, Lopresti B, Mathis C, Zigmond M, Cameron J. Impact of exercise on caudate and putamen in a non-human primate model of Parkinson's disease Neuroimage. 41: T129. DOI: 10.1016/J.Neuroimage.2008.04.097  0.537
2007 Quintero JE, Day BK, Zhang Z, Grondin R, Stephens ML, Huettl P, Pomerleau F, Gash DM, Gerhardt GA. Amperometric measures of age-related changes in glutamate regulation in the cortex of rhesus monkeys. Experimental Neurology. 208: 238-46. PMID 17927982 DOI: 10.1016/J.Expneurol.2007.08.002  0.305
2007 Cass WA, Grondin R, Andersen AH, Zhang Z, Hardy PA, Hussey-Andersen LK, Rayens WS, Gerhardt GA, Gash DM. Iron accumulation in the striatum predicts aging-related decline in motor function in rhesus monkeys. Neurobiology of Aging. 28: 258-71. PMID 16442671 DOI: 10.1016/J.Neurobiolaging.2005.12.010  0.351
2006 Salvatore MF, Ai Y, Fischer B, Zhang AM, Grondin RC, Zhang Z, Gerhardt GA, Gash DM. Point source concentration of GDNF may explain failure of phase II clinical trial. Experimental Neurology. 202: 497-505. PMID 16962582 DOI: 10.1016/J.Expneurol.2006.07.015  0.321
2006 Zhang Z, Andersen AH, Ai Y, Loveland A, Hardy PA, Gerhardt GA, Gash DM. Assessing nigrostriatal dysfunctions by pharmacological MRI in parkinsonian rhesus macaques. Neuroimage. 33: 636-43. PMID 16949305 DOI: 10.1016/J.Neuroimage.2006.07.004  0.405
2005 Gash DM, Zhang Z, Ai Y, Grondin R, Coffey R, Gerhardt GA. Trophic factor distribution predicts functional recovery in parkinsonian monkeys. Annals of Neurology. 58: 224-33. PMID 16049934 DOI: 10.1002/Ana.20549  0.412
2004 Maswood N, Young J, Tilmont E, Zhang Z, Gash DM, Gerhardt GA, Grondin R, Roth GS, Mattison J, Lane MA, Carson RE, Cohen RM, Mouton PR, Quigley C, Mattson MP, et al. Caloric restriction increases neurotrophic factor levels and attenuates neurochemical and behavioral deficits in a primate model of Parkinson's disease. Proceedings of the National Academy of Sciences of the United States of America. 101: 18171-6. PMID 15604149 DOI: 10.1073/Pnas.0405831102  0.397
2003 Grondin R, Zhang Z, Ai Y, Gash DM, Gerhardt GA. Intracranial delivery of proteins and peptides as a therapy for neurodegenerative diseases. Progress in Drug Research. Fortschritte Der Arzneimittelforschung. Progrã¨S Des Recherches Pharmaceutiques. 61: 101-23. PMID 14674610 DOI: 10.1007/978-3-0348-8049-7_4  0.389
2003 Ai Y, Markesbery W, Zhang Z, Grondin R, Elseberry D, Gerhardt GA, Gash DM. Intraputamenal infusion of GDNF in aged rhesus monkeys: distribution and dopaminergic effects. The Journal of Comparative Neurology. 461: 250-61. PMID 12724841 DOI: 10.1002/Cne.10689  0.368
2003 Grondin R, Cass WA, Zhang Z, Stanford JA, Gash DM, Gerhardt GA. Glial cell line-derived neurotrophic factor increases stimulus-evoked dopamine release and motor speed in aged rhesus monkeys. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 1974-80. PMID 12629203 DOI: 10.1523/Jneurosci.23-05-01974.2003  0.381
2002 Maswood N, Grondin R, Zhang Z, Stanford JA, Surgener SP, Gash DM, Gerhardt GA. Effects of chronic intraputamenal infusion of glial cell line-derived neurotrophic factor (GDNF) in aged Rhesus monkeys. Neurobiology of Aging. 23: 881-9. PMID 12392792 DOI: 10.1016/S0197-4580(02)00022-2  0.417
2002 Grondin R, Zhang Z, Yi A, Cass WA, Maswood N, Andersen AH, Elsberry DD, Klein MC, Gerhardt GA, Gash DM. Chronic, controlled GDNF infusion promotes structural and functional recovery in advanced parkinsonian monkeys. Brain : a Journal of Neurology. 125: 2191-201. PMID 12244077 DOI: 10.1093/Brain/Awf234  0.425
2002 Andersen AH, Zhang Z, Barber T, Rayens WS, Zhang J, Grondin R, Hardy P, Gerhardt GA, Gash DM. Functional MRI studies in awake rhesus monkeys: methodological and analytical strategies. Journal of Neuroscience Methods. 118: 141-52. PMID 12204305 DOI: 10.1016/S0165-0270(02)00123-1  0.305
2002 Gerhardt GA, Cass WA, Yi A, Zhang Z, Gash DM. Changes in somatodendritic but not terminal dopamine regulation in aged rhesus monkeys. Journal of Neurochemistry. 80: 168-77. PMID 11796755 DOI: 10.1046/J.0022-3042.2001.00684.X  0.387
2001 Grondin R, Zhang Z, Elsberry DD, Gerhardt GA, Gash DM. Chronic Intracerebral Delivery of Trophic Factors via a Programmable Pump as a Treatment for Parkinsonism. Methods in Molecular Medicine. 62: 257-67. PMID 21318781 DOI: 10.1385/1-59259-142-6:257  0.38
2001 Zhang Z, Andersen A, Grondin R, Barber T, Avison R, Gerhardt G, Gash D. Pharmacological MRI mapping of age-associated changes in basal ganglia circuitry of awake rhesus monkeys. Neuroimage. 14: 1159-67. PMID 11697947 DOI: 10.1006/Nimg.2001.0902  0.418
2000 Zhang Z, Andersen A, Smith C, Grondin R, Gerhardt G, Gash D. Motor slowing and parkinsonian signs in aging rhesus monkeys mirror human aging. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. 55: B473-80. PMID 11034220 DOI: 10.1093/Gerona/55.10.B473  0.321
2000 Zhang Z, Andersen AH, Avison MJ, Gerhardt GA, Gash DM. Functional MRI of apomorphine activation of the basal ganglia in awake rhesus monkeys. Brain Research. 852: 290-6. PMID 10678755 DOI: 10.1016/S0006-8993(99)02243-X  0.366
2000 Grondin R, Zhang Z, Gerhardt GA, Gash DM. Dopaminergic therapy improves upper limb motor performance in aged rhesus monkeys. Annals of Neurology. 48: 250-253. DOI: 10.1002/1531-8249(200008)48:2<250::Aid-Ana16>3.0.Co;2-1  0.338
1999 Chen Q, Andersen AH, Zhang Z, Ovadia A, Cass WA, Gash DM, Avison MJ. Functional MRI of basal ganglia responsiveness to levodopa in parkinsonian rhesus monkeys. Experimental Neurology. 158: 63-75. PMID 10448418 DOI: 10.1006/Exnr.1999.7089  0.396
1999 Zhang Z, Zhang M, Ai Y, Avison C, Gash DM. MPTP-induced pallidal lesions in rhesus monkeys Experimental Neurology. 155: 140-149. PMID 9918713 DOI: 10.1006/Exnr.1998.6976  0.382
1999 Gerhardt GA, Cass WA, Huettl P, Brock S, Zhang Z, Gash DM. GDNF improves dopamine function in the substantia nigra but not the putamen of unilateral MPTP-lesioned rhesus monkeys. Brain Research. 817: 163-71. PMID 9889359 DOI: 10.1016/S0006-8993(98)01244-X  0.379
1999 Duan W, Zhang Z, Gash DM, Mattson MP. Participation of prostate apoptosis response-4 in degeneration of dopaminergic neurons in models of Parkinson's disease Annals of Neurology. 46: 587-597. DOI: 10.1002/1531-8249(199910)46:4<587::Aid-Ana6>3.0.Co;2-M  0.352
1998 Gash DM, Zhang Z, Gerhardt G. Neuroprotective and neurorestorative properties of GDNF. Annals of Neurology. 44: S121-5. PMID 9749583 DOI: 10.1002/Ana.410440718  0.417
1997 Miyoshi Y, Zhang Z, Ovadia A, Lapchak PA, Collins F, Hilt D, Lebel C, Kryscio R, Gash DM. Glial cell line-derived neurotrophic factor-levodopa interactions and reduction of side effects in parkinsonian monkeys Annals of Neurology. 42: 208-214. PMID 9266731 DOI: 10.1002/Ana.410420212  0.356
1996 Gash DM, Zhang Z, Ovadia A, Cass WA, Yi A, Simmerman L, Russell D, Martin D, Lapchak PA, Collins F, Hoffer BJ, Gerhardt GA. Functional recovery in parkinsonian monkeys treated with GDNF. Nature. 380: 252-5. PMID 8637574 DOI: 10.1038/380252A0  0.425
1996 Gerhardt GA, Cass WA, Hudson J, Henson M, Zhang Z, Ovadia A, Hoffer BJ, Gash DM. In vivo electrochemical studies of dopamine overflow and clearance in the striatum of normal and MPTP-treated rhesus monkeys. Journal of Neurochemistry. 66: 579-88. PMID 8592127 DOI: 10.1046/J.1471-4159.1996.66020579.X  0.37
1995 Gash DM, Zhang Z, Cass WA, Ovadia A, Simmerman L, Martin D, Russell D, Collins F, Hoffer BJ, Gerhardt GA. Morphological and functional effects of intranigrally administered GDNF in normal rhesus monkeys. The Journal of Comparative Neurology. 363: 345-58. PMID 8847404 DOI: 10.1002/Cne.903630302  0.401
1995 Gerhardt GA, Cass WA, Henson M, Zhang Z, Ovadia A, Hoffer BJ, Gash DM. Age-related changes in potassium-evoked overflow of dopamine in the striatum of the rhesus monkey. Neurobiology of Aging. 16: 939-46. PMID 8622785 DOI: 10.1016/0197-4580(95)02013-6  0.352
1995 Ovadia A, Zhang Z, Gash DM. Increased susceptibility to MPTP toxicity in middle-aged rhesus monkeys Neurobiology of Aging. 16: 931-937. PMID 8622784 DOI: 10.1016/0197-4580(95)02012-8  0.318
1995 Cass WA, Gerhardt GA, Zhang Z, Ovadia A, Gash DM. Increased dopamine clearance in the non-lesioned striatum of rhesus monkeys with unilateral 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) striatal lesions. Neuroscience Letters. 185: 52-5. PMID 7731554 DOI: 10.1016/0304-3940(94)11223-6  0.336
1994 Greenamyre JT, Eller RV, Zhang Z, Ovadia A, Kurlan R, Gash DM. Antiparkinsonian effects of remacemide hydrochloride, a glutamate antagonist, in rodent and primate models of Parkinson's disease. Annals of Neurology. 35: 655-61. PMID 8210221 DOI: 10.1002/Ana.410350605  0.33
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