Aloysius Klingelhutz - Publications

Affiliations: 
University of Iowa, Iowa City, IA 
Area:
Molecular Biology, Cell Biology

55 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Schlievert PM, Cahill MP, Hostager BS, Brosnahan AJ, Klingelhutz AJ, Gourronc FA, Bishop GA, Leung DYM. Staphylococcal Superantigens Stimulate Epithelial Cells through CD40 To Produce Chemokines. Mbio. 10. PMID 30890614 DOI: 10.1128/mBio.00214-19  0.76
2018 Klingelhutz AJ, Gourronc FA, Chaly A, Wadkins DA, Burand AJ, Markan KR, Idiga SO, Wu M, Potthoff MJ, Ankrum JA. Scaffold-free generation of uniform adipose spheroids for metabolism research and drug discovery. Scientific Reports. 8: 523. PMID 29323267 DOI: 10.1038/s41598-017-19024-z  0.76
2017 Kulhankova K, Kinney KJ, Stach JM, Gourronc FA, Grumbach IM, Klingelhutz AJ, Salgado-Pabón W. The Superantigen Toxic Shock Syndrome Toxin-1 Alters Human Aortic Endothelial Cell Function. Infection and Immunity. PMID 29229737 DOI: 10.1128/IAI.00848-17  0.76
2017 Gourronc FA, Robertson LW, Klingelhutz AJ. A delayed proinflammatory response of human preadipocytes to PCB126 is dependent on the aryl hydrocarbon receptor. Environmental Science and Pollution Research International. PMID 28699004 DOI: 10.1007/s11356-017-9676-z  1
2016 Gadupudi GS, Klingelhutz AJ, Robertson LW. Diminished phosphorylation of CREB is a key event in the dysregulation of gluconeogenesis and glycogenolysis in PCB126 hepatotoxicity. Chemical Research in Toxicology. PMID 27509375 DOI: 10.1021/acs.chemrestox.6b00172  1
2016 Littlejohn NK, Keen HL, Weidemann BJ, Claflin KE, Tobin KV, Markan KR, Park S, Naber MC, Gourronc FA, Pearson NA, Liu X, Morgan DA, Klingelhutz AJ, Potthoff MJ, Rahmouni K, et al. Suppression of Resting Metabolism by the Angiotensin AT2 Receptor. Cell Reports. PMID 27477281 DOI: 10.1016/j.celrep.2016.07.003  0.76
2015 Schlievert PM, Salgado-Pabón W, Klingelhutz AJ. Does Staphylococcus aureus have a role in the development of Type 2 diabetes mellitus? Future Microbiology. 10: 1549-52. PMID 26439811 DOI: 10.2217/fmb.15.95  1
2015 Gadupudi GS, Klaren WD, Olivier AK, Klingelhutz AJ, Robertson LW. PCB126-induced disruption in gluconeogenesis and fatty acid oxidation precedes fatty liver in male rats. Toxicological Sciences : An Official Journal of the Society of Toxicology. PMID 26396156 DOI: 10.1093/toxsci/kfv215  1
2015 Merriman JA, Klingelhutz AJ, Diekema DJ, Leung DY, Schlievert PM. Novel Staphylococcus aureus Secreted Protein Alters Keratinocyte Proliferation and Elicits a Proinflammatory Response In Vitro and In Vivo. Biochemistry. 54: 4855-62. PMID 26177220 DOI: 10.1021/acs.biochem.5b00523  1
2015 Vu BG, Stach CS, Kulhankova K, Salgado-Pabón W, Klingelhutz AJ, Schlievert PM. Chronic superantigen exposure induces systemic inflammation, elevated bloodstream endotoxin, and abnormal glucose tolerance in rabbits: possible role in diabetes. Mbio. 6: e02554. PMID 25714716 DOI: 10.1128/mBio.02554-14  1
2015 Gadupudi G, Gourronc FA, Ludewig G, Robertson LW, Klingelhutz AJ. PCB126 inhibits adipogenesis of human preadipocytes. Toxicology in Vitro : An International Journal Published in Association With Bibra. 29: 132-41. PMID 25304490 DOI: 10.1016/j.tiv.2014.09.015  1
2014 Hagen J, Muniz VP, Falls KC, Reed SM, Taghiyev AF, Quelle FW, Gourronc FA, Klingelhutz AJ, Major HJ, Askeland RW, Sherman SK, O'Dorisio TM, Bellizzi AM, Howe JR, Darbro BW, et al. RABL6A promotes G1-S phase progression and pancreatic neuroendocrine tumor cell proliferation in an Rb1-dependent manner. Cancer Research. 74: 6661-70. PMID 25273089 DOI: 10.1158/0008-5472.CAN-13-3742  1
2014 Jang JH, Bruse S, Huneidi S, Schrader RM, Monick MM, Lin Y, Carter AB, Klingelhutz AJ, Nyunoya T. Acrolein-exposed normal human lung fibroblasts in vitro: cellular senescence, enhanced telomere erosion, and degradation of werner's syndrome protein. Environmental Health Perspectives. 122: 955-62. PMID 24747221 DOI: 10.1289/ehp.1306911  1
2013 Vu BG, Gourronc FA, Bernlohr DA, Schlievert PM, Klingelhutz AJ. Staphylococcal superantigens stimulate immortalized human adipocytes to produce chemokines. Plos One. 8: e77988. PMID 24205055 DOI: 10.1371/journal.pone.0077988  1
2013 Gourronc FA, Rockey WM, Thiel WH, Giangrande PH, Klingelhutz AJ. Identification of RNA aptamers that internalize into HPV-16 E6/E7 transformed tonsillar epithelial cells. Virology. 446: 325-33. PMID 24074596 DOI: 10.1016/j.virol.2013.08.015  1
2013 Hernandez LI, Flenker KS, Hernandez FJ, Klingelhutz AJ, McNamara JO, Giangrande PH. Methods for Evaluating Cell-Specific, Cell-Internalizing RNA Aptamers. Pharmaceuticals (Basel, Switzerland). 6: 295-319. PMID 23894227 DOI: 10.3390/ph6030295  1
2013 Kimple RJ, Smith MA, Blitzer GC, Torres AD, Martin JA, Yang RZ, Peet CR, Lorenz LD, Nickel KP, Klingelhutz AJ, Lambert PF, Harari PM. Enhanced radiation sensitivity in HPV-positive head and neck cancer. Cancer Research. 73: 4791-800. PMID 23749640 DOI: 10.1158/0008-5472.CAN-13-0587  1
2012 Klingelhutz AJ, Roman A. Cellular transformation by human papillomaviruses: lessons learned by comparing high- and low-risk viruses. Virology. 424: 77-98. PMID 22284986 DOI: 10.1016/j.virol.2011.12.018  1
2012 Vermeer PD, Bell M, Lee K, Vermeer DW, Wieking BG, Bilal E, Bhanot G, Drapkin RI, Ganesan S, Klingelhutz AJ, Hendriks WJ, Lee JH. ErbB2, EphrinB1, Src kinase and PTPN13 signaling complex regulates MAP kinase signaling in human cancers. Plos One. 7: e30447. PMID 22279592 DOI: 10.1371/journal.pone.0030447  0.32
2012 Bulysheva AA, Bowlin GL, Klingelhutz AJ, Yeudall WA. Low-temperature electrospun silk scaffold for in vitro mucosal modeling. Journal of Biomedical Materials Research. Part A. 100: 757-67. PMID 22238242 DOI: 10.1002/jbm.a.33288  1
2012 Gourronc FA, Klingelhutz AJ. Therapeutic opportunities: telomere maintenance in inducible pluripotent stem cells. Mutation Research. 730: 98-105. PMID 21605571 DOI: 10.1016/j.mrfmmm.2011.05.008  0.76
2011 Senthilkumar PK, Klingelhutz AJ, Jacobus JA, Lehmler H, Robertson LW, Ludewig G. Airborne polychlorinated biphenyls (PCBs) reduce telomerase activity and shorten telomere length in immortal human skin keratinocytes (HaCat). Toxicology Letters. 204: 64-70. PMID 21530622 DOI: 10.1016/j.toxlet.2011.04.012  1
2011 Saccoccio FM, Sauer AL, Cui X, Armstrong AE, Habib el-SE, Johnson DC, Ryckman BJ, Klingelhutz AJ, Adler SP, McVoy MA. Peptides from cytomegalovirus UL130 and UL131 proteins induce high titer antibodies that block viral entry into mucosal epithelial cells. Vaccine. 29: 2705-11. PMID 21310190 DOI: 10.1016/j.vaccine.2011.01.079  1
2011 Westin ER, Aykin-Burns N, Buckingham EM, Spitz DR, Goldman FD, Klingelhutz AJ. The p53/p21(WAF/CIP) pathway mediates oxidative stress and senescence in dyskeratosis congenita cells with telomerase insufficiency. Antioxidants & Redox Signaling. 14: 985-97. PMID 21087144 DOI: 10.1089/ars.2010.3444  1
2010 Agarwal S, Loh YH, McLoughlin EM, Huang J, Park IH, Miller JD, Huo H, Okuka M, Dos Reis RM, Loewer S, Ng HH, Keefe DL, Goldman FD, Klingelhutz AJ, Liu L, et al. Telomere elongation in induced pluripotent stem cells from dyskeratosis congenita patients. Nature. 464: 292-6. PMID 20164838 DOI: 10.1038/nature08792  1
2010 Gourronc FA, Robertson mM, Herrig AK, Lansdorp PM, Goldman FD, Klingelhutz AJ. Proliferative defects in dyskeratosis congenita skin keratinocytes are corrected by expression of the telomerase reverse transcriptase, TERT, or by activation of endogenous telomerase through expression of papillomavirus E6/E7 or the telomerase RNA component, TERC. Experimental Dermatology. 19: 279-88. PMID 19558498 DOI: 10.1111/j.1600-0625.2009.00916.x  0.76
2009 Yu L, Hitchler MJ, Sun W, Sarsour EH, Goswami PC, Klingelhutz AJ, Domann FE. AP-2alpha Inhibits c-MYC Induced Oxidative Stress and Apoptosis in HaCaT Human Keratinocytes. Journal of Oncology. 2009: 780874. PMID 20066163 DOI: 10.1155/2009/780874  0.32
2009 Lace MJ, Anson JR, Klingelhutz AJ, Lee JH, Bossler AD, Haugen TH, Turek LP. Human papillomavirus (HPV) type 18 induces extended growth in primary human cervical, tonsillar, or foreskin keratinocytes more effectively than other high-risk mucosal HPVs. Journal of Virology. 83: 11784-94. PMID 19740985 DOI: 10.1128/JVI.01370-09  1
2009 Hoover AC, Strand GL, Nowicki PN, Anderson ME, Vermeer PD, Klingelhutz AJ, Bossler AD, Pottala JV, Hendriks WJ, Lee JH. Impaired PTPN13 phosphatase activity in spontaneous or HPV-induced squamous cell carcinomas potentiates oncogene signaling through the MAP kinase pathway. Oncogene. 28: 3960-70. PMID 19734941 DOI: 10.1038/onc.2009.251  0.32
2009 Lace MJ, Anson JR, Klingelhutz AJ, Harada H, Taniguchi T, Bossler AD, Haugen TH, Turek LP. Interferon-beta treatment increases human papillomavirus early gene transcription and viral plasmid genome replication by activating interferon regulatory factor (IRF)-1. Carcinogenesis. 30: 1336-44. PMID 19541854 DOI: 10.1093/carcin/bgp150  1
2008 Jacobus JA, Flor S, Klingelhutz A, Robertson LW, Ludewig G. 2-(4'-CHLOROPHENYL)-1,4-BENZOQUINONE INCREASES THE FREQUENCY OF MICRONUCLEI AND SHORTENS TELOMERES. Environmental Toxicology and Pharmacology. 25: 267-272. PMID 18438462 DOI: 10.1016/j.etap.2007.10.022  1
2008 Spanos WC, Hoover A, Harris GF, Wu S, Strand GL, Anderson ME, Klingelhutz AJ, Hendriks W, Bossler AD, Lee JH. The PDZ binding motif of human papillomavirus type 16 E6 induces PTPN13 loss, which allows anchorage-independent growth and synergizes with ras for invasive growth. Journal of Virology. 82: 2493-500. PMID 18160445 DOI: 10.1128/JVI.02188-07  1
2008 Spanos WC, Geiger J, Anderson ME, Harris GF, Bossler AD, Smith RB, Klingelhutz AJ, Lee JH. Deletion of the PDZ motif of HPV16 E6 preventing immortalization and anchorage-independent growth in human tonsil epithelial cells. Head & Neck. 30: 139-47. PMID 17657785 DOI: 10.1002/hed.20673  1
2007 Hoover AC, Spanos WC, Harris GF, Anderson ME, Klingelhutz AJ, Lee JH. The role of human papillomavirus 16 E6 in anchorage-independent and invasive growth of mouse tonsil epithelium. Archives of Otolaryngology--Head & Neck Surgery. 133: 495-502. PMID 17515506 DOI: 10.1001/archotol.133.5.495  1
2007 Westin ER, Chavez E, Lee KM, Gourronc FA, Riley S, Lansdorp PM, Goldman FD, Klingelhutz AJ. Telomere restoration and extension of proliferative lifespan in dyskeratosis congenita fibroblasts. Aging Cell. 6: 383-94. PMID 17381549 DOI: 10.1111/j.1474-9726.2007.00288.x  0.76
2006 Berger KL, Barriga F, Lace MJ, Turek LP, Zamba GJ, Domann FE, Lee JH, Klingelhutz AJ. Cervical keratinocytes containing stably replicating extrachromosomal HPV-16 are refractory to transformation by oncogenic H-Ras. Virology. 356: 68-78. PMID 16945398 DOI: 10.1016/j.virol.2006.07.039  1
2006 Darbro BW, Lee KM, Nguyen NK, Domann FE, Klingelhutz AJ. Methylation of the p16(INK4a) promoter region in telomerase immortalized human keratinocytes co-cultured with feeder cells. Oncogene. 25: 7421-33. PMID 16767161 DOI: 10.1038/sj.onc.1209729  1
2006 James MA, Lee JH, Klingelhutz AJ. HPV16-E6 associated hTERT promoter acetylation is E6AP dependent, increased in later passage cells and enhanced by loss of p300. International Journal of Cancer. Journal International Du Cancer. 119: 1878-85. PMID 16708385 DOI: 10.1002/ijc.22064  0.32
2006 James MA, Lee JH, Klingelhutz AJ. Human papillomavirus type 16 E6 activates NF-kappaB, induces cIAP-2 expression, and protects against apoptosis in a PDZ binding motif-dependent manner. Journal of Virology. 80: 5301-7. PMID 16699010 DOI: 10.1128/JVI.01942-05  0.32
2005 Darbro BW, Schneider GB, Klingelhutz AJ. Co-regulation of p16INK4A and migratory genes in culture conditions that lead to premature senescence in human keratinocytes. The Journal of Investigative Dermatology. 125: 499-509. PMID 16117791 DOI: 10.1111/j.0022-202X.2005.23844.x  0.4
2005 Klingelhutz AJ, Qian Q, Phillips SL, Gourronc FA, Darbro BW, Patil SR. Amplification of the chromosome 20q region is associated with expression of HPV-16 E7 in human airway and anogenital epithelial cells. Virology. 340: 237-44. PMID 16051300 DOI: 10.1016/j.virol.2005.06.027  1
2005 Ault KA, Allen HK, Phillips SL, Zimmerman MB, Klingelhutz AJ. Telomerase activity as a potential diagnostic marker for triage of abnormal Pap smears. Journal of Lower Genital Tract Disease. 9: 93-9. PMID 15870530 DOI: 10.1097/00128360-200504000-00005  1
2005 Peterson ML, Ault K, Kremer MJ, Klingelhutz AJ, Davis CC, Squier CA, Schlievert PM. The innate immune system is activated by stimulation of vaginal epithelial cells with Staphylococcus aureus and toxic shock syndrome toxin 1. Infection and Immunity. 73: 2164-74. PMID 15784559 DOI: 10.1128/IAI.73.4.2164-2174.2005  1
2004 Lee JH, Yi SM, Anderson ME, Berger KL, Welsh MJ, Klingelhutz AJ, Ozbun MA. Propagation of infectious human papillomavirus type 16 by using an adenovirus and Cre/LoxP mechanism. Proceedings of the National Academy of Sciences of the United States of America. 101: 2094-9. PMID 14769917 DOI: 10.1073/pnas.0308615100  1
2004 Morrison TE, Mauser A, Klingelhutz A, Kenney SC. Epstein-Barr virus immediate-early protein BZLF1 inhibits tumor necrosis factor alpha-induced signaling and apoptosis by downregulating tumor necrosis factor receptor 1. Journal of Virology. 78: 544-9. PMID 14671137 DOI: 10.1128/JVI.78.1.544-549.2004  1
2003 Morrison JA, Klingelhutz AJ, Raab-Traub N. Epstein-Barr virus latent membrane protein 2A activates beta-catenin signaling in epithelial cells. Journal of Virology. 77: 12276-84. PMID 14581564 DOI: 10.1128/JVI.77.22.12276-12284.2003  1
2003 Duffy CL, Phillips SL, Klingelhutz AJ. Microarray analysis identifies differentiation-associated genes regulated by human papillomavirus type 16 E6. Virology. 314: 196-205. PMID 14517073 DOI: 10.1016/S0042-6822(03)00390-8  1
2003 Zabner J, Karp P, Seiler M, Phillips SL, Mitchell CJ, Saavedra M, Welsh M, Klingelhutz AJ. Development of cystic fibrosis and noncystic fibrosis airway cell lines. American Journal of Physiology. Lung Cellular and Molecular Physiology. 284: L844-54. PMID 12676769 DOI: 10.1152/ajplung.00355.2002  1
2002 Mauser A, Holley-Guthrie E, Zanation A, Yarborough W, Kaufmann W, Klingelhutz A, Seaman WT, Kenney S. The Epstein-Barr virus immediate-early protein BZLF1 induces expression of E2F-1 and other proteins involved in cell cycle progression in primary keratinocytes and gastric carcinoma cells. Journal of Virology. 76: 12543-52. PMID 12438580 DOI: 10.1128/JVI.76.24.12543-12552.2002  1
2002 Sprague DL, Phillips SL, Mitchell CJ, Berger KL, Lace M, Turek LP, Klingelhutz AJ. Telomerase activation in cervical keratinocytes containing stably replicating human papillomavirus type 16 episomes. Virology. 301: 247-54. PMID 12359427 DOI: 10.1006/viro.2002.1542  1
2002 Martin JA, Forest E, Block JA, Klingelhutz AJ, Whited B, Gitelis S, Wilkey A, Buckwalter JA. Malignant transformation in human chondrosarcoma cells supported by telomerase activation and tumor suppressor inactivation. Cell Growth & Differentiation : the Molecular Biology Journal of the American Association For Cancer Research. 13: 397-407. PMID 12354749  1
2002 Martin JA, Mitchell CJ, Klingelhutz AJ, Buckwalter JA. Effects of telomerase and viral oncogene expression on the in vitro growth of human chondrocytes. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. 57: B48-53. PMID 11818423  0.4
1998 Kiyono T, Foster SA, Koop JI, McDougall JK, Galloway DA, Klingelhutz AJ. Both Rb/p16INK4a inactivation and telomerase activity are required to immortalize human epithelial cells. Nature. 396: 84-8. PMID 9817205 DOI: 10.1038/23962  1
1997 Anderson S, Shera K, Ihle J, Billman L, Goff B, Greer B, Tamimi H, McDougall J, Klingelhutz A. Telomerase activation in cervical cancer. The American Journal of Pathology. 151: 25-31. PMID 9212727  1
1994 Klingelhutz AJ, Barber SA, Smith PP, Dyer K, McDougall JK. Restoration of telomeres in human papillomavirus-immortalized human anogenital epithelial cells. Molecular and Cellular Biology. 14: 961-9. PMID 8289836  1
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