Year |
Citation |
Score |
2023 |
Perales-Linares R, Leli NM, Mohei H, Beghi S, Rivera OD, Kostopoulos N, Giglio A, George SS, Uribe-Herranz M, Costabile F, Pierini S, Pustylnikov S, Skoufos G, Barash Y, Hatzigeorgiou AG, ... Koumenis C, et al. Parkin deficiency suppresses antigen presentation to promote tumor immune evasion and immunotherapy resistance. Cancer Research. PMID 37578274 DOI: 10.1158/0008-5472.CAN-22-2499 |
0.324 |
|
2022 |
Roby KC, Lieberman A, Kim BJ, Rodríguez NZ, Posimo JM, Tsang T, Verginadis II, Puré E, Brady DC, Koumenis C, Ryeom S. Loss of p19Arf Promotes Fibroblast Survival During Leucine Deprivation. Biology Open. PMID 34994382 DOI: 10.1242/bio.058728 |
0.339 |
|
2020 |
Chao HH, Karagounis IV, Thomas C, François NB, Facciabene A, Koumenis C, Maity A. Combination of CHEK1/2 inhibition and ionizing radiation results in abscopal tumor response through increased micronuclei formation. Oncogene. PMID 32335582 DOI: 10.1038/S41388-020-1300-X |
0.456 |
|
2020 |
Huang M, Zhang D, Wu JY, Xing K, Yeo E, Li C, Zhang L, Holland E, Yao L, Qin L, Binder ZA, O'Rourke DM, Brem S, Koumenis C, Gong Y, et al. Wnt-mediated endothelial transformation into mesenchymal stem cell-like cells induces chemoresistance in glioblastoma. Science Translational Medicine. 12. PMID 32102932 DOI: 10.1126/Scitranslmed.Aay7522 |
0.397 |
|
2020 |
Thomas C, Karagounis I, Srivastava R, Kumar S, Francois N, Nikolos F, Bado I, Chao H, Koumenis C, Krishnamurthy S, Ueno NT, Chakrabarti R, Maity A. Abstract PD7-02: Estrogen receptor β suppresses metastasis of inflammatory breast cancer by regulating signaling that promotes cytoskeleton remodeling Cancer Research. 80. DOI: 10.1158/1538-7445.Sabcs19-Pd7-02 |
0.411 |
|
2020 |
Karagounis IV, Pierini S, François N, Thomas C, Xu X, Koumenis C, Facciabene A, Maity A. Abstract 6509: Hypofractionated radiotherapy as a vaccine in combination with the TLR7/8 agonist resiquimod leads to significant abscopal tumor response and persistence antitumor immunity Cancer Research. 80: 6509-6509. DOI: 10.1158/1538-7445.Am2020-6509 |
0.405 |
|
2019 |
Bhardwaj M, Leli NM, Koumenis C, Amaravadi RK. Regulation of autophagy by canonical and non-canonical ER stress responses. Seminars in Cancer Biology. PMID 31838023 DOI: 10.1016/J.Semcancer.2019.11.007 |
0.421 |
|
2019 |
Uribe-Herranz M, Rafail S, Beghi S, Gil-de-Gómez L, Verginadis I, Bittinger K, Pustylnikov S, Pierini S, Perales-Linares R, Blair IA, Mesaros CA, Snyder NW, Bushman F, Koumenis C, Facciabene A. Gut microbiota modulate dendritic cell antigen presentation and radiotherapy-induced antitumor immune response. The Journal of Clinical Investigation. PMID 31815742 DOI: 10.1172/Jci124332 |
0.356 |
|
2019 |
Tameire F, Verginadis II, Leli NM, Polte C, Conn CS, Ojha R, Salas Salinas C, Chinga F, Monroy AM, Fu W, Wang P, Kossenkov A, Ye J, Amaravadi RK, Ignatova Z, ... ... Koumenis C, et al. ATF4 couples MYC-dependent translational activity to bioenergetic demands during tumour progression. Nature Cell Biology. 21: 889-899. PMID 31263264 DOI: 10.1038/S41556-019-0347-9 |
0.428 |
|
2019 |
Gui J, Katlinski KV, Koumenis C, Diehl JA, Fuchs SY. The PKR-like endoplasmic reticulum kinase promotes the dissemination of Myc-induced leukemic cells. Molecular Cancer Research : McR. PMID 30902831 DOI: 10.1158/1541-7786.Mcr-19-0002 |
0.413 |
|
2019 |
Ortiz A, Gui J, Zahedi F, Yu P, Cho C, Bhattacharya S, Carbone CJ, Yu Q, Katlinski KV, Katlinskaya YV, Handa S, Haas V, Volk SW, Brice AK, Wals K, ... ... Koumenis C, et al. An Interferon-Driven Oxysterol-Based Defense against Tumor-Derived Extracellular Vesicles. Cancer Cell. 35: 33-45.e6. PMID 30645975 DOI: 10.1016/J.Ccell.2018.12.001 |
0.37 |
|
2019 |
Chatterjee S, Pietrofesa RA, Park K, Tao JQ, Carabe-Fernandez A, Berman AT, Koumenis C, Sielecki T, Christofidou-Solomidou M. LGM2605 Reduces Space Radiation-Induced NLRP3 Inflammasome Activation and Damage in In Vitro Lung Vascular Networks. International Journal of Molecular Sciences. 20. PMID 30621290 DOI: 10.3390/Ijms20010176 |
0.316 |
|
2019 |
Karagounis IV, Chao H, Tomas C, Koumenis C, Maity A. Abstract LB-116: Combination of a cell cycle checkpoint kinase inhibitor and ionizing radiation leads to abscopal tumor response through increased CD8+ infiltration Cancer Research. DOI: 10.1158/1538-7445.Sabcs18-Lb-116 |
0.384 |
|
2018 |
Ojha R, Leli NM, Onorati A, Piao S, Verginadis II, Tameire F, Rebecca VW, Chude CI, Murugan S, Fennelly C, Noguera-Ortega E, Liu S, Xu X, Krepler C, Xiao M, ... ... Koumenis C, et al. ER translocation of the MAPK pathway drives therapy resistance in BRAF mutant melanoma. Cancer Discovery. PMID 30563872 DOI: 10.1158/2159-8290.Cd-18-0348 |
0.407 |
|
2018 |
Rivera-Reyes A, Ye S, E Marino G, Egolf S, E Ciotti G, Chor S, Liu Y, Posimo JM, Park PMC, Pak K, Babichev Y, Sostre-Colón J, Tameire F, Leli NM, Koumenis C, et al. YAP1 enhances NF-κB-dependent and independent effects on clock-mediated unfolded protein responses and autophagy in sarcoma. Cell Death & Disease. 9: 1108. PMID 30382078 DOI: 10.1038/S41419-018-1142-4 |
0.363 |
|
2018 |
Bi Y, Verginadis II, Dey S, Lin L, Guo L, Zheng Y, Koumenis C. Radiosensitization by the PARP inhibitor olaparib in BRCA1-proficient and deficient high-grade serous ovarian carcinomas. Gynecologic Oncology. PMID 30025822 DOI: 10.1016/J.Ygyno.2018.07.002 |
0.317 |
|
2018 |
Leli NM, Koumenis C. Pro-tumorigenic AMPK in glioblastoma Nature Cell Biology. 20: 736-737. PMID 29915356 DOI: 10.1038/S41556-018-0129-9 |
0.348 |
|
2018 |
Walton ZE, Patel CH, Brooks RC, Yu Y, Ibrahim-Hashim A, Riddle M, Porcu A, Jiang T, Ecker BL, Tameire F, Koumenis C, Weeraratna AT, Welsh DK, Gillies R, Alwine JC, et al. Acid Suspends the Circadian Clock in Hypoxia through Inhibition of mTOR. Cell. PMID 29861175 DOI: 10.1016/J.Cell.2018.05.009 |
0.397 |
|
2018 |
Nguyen HG, Conn CS, Kye Y, Xue L, Forester CM, Cowan JE, Hsieh AC, Cunningham JT, Truillet C, Tameire F, Evans MJ, Evans CP, Yang JC, Hann B, Koumenis C, et al. Development of a stress response therapy targeting aggressive prostate cancer. Science Translational Medicine. 10. PMID 29720449 DOI: 10.1126/Scitranslmed.Aar2036 |
0.441 |
|
2018 |
Yang Z, Zhang J, Jiang D, Khatri P, Solow-Cordero DE, Toesca DAS, Koumenis C, Denko NC, Giaccia AJ, Le QT, Koong AC. A Human Genome-wide RNAi Screen Reveals Diverse Modulators that Mediate IRE1α-XBP1 Activation. Molecular Cancer Research : McR. PMID 29440447 DOI: 10.1158/1541-7786.Mcr-17-0307 |
0.384 |
|
2018 |
Wang Y, Xu H, Liu T, Huang M, Butter PP, Li C, Zhang L, Kao GD, Gong Y, Maity A, Koumenis C, Fan Y. Temporal DNA-PK activation drives genomic instability and therapy resistance in glioma stem cells. Jci Insight. 3. PMID 29415883 DOI: 10.1172/Jci.Insight.98096 |
0.317 |
|
2017 |
Bu Y, Yoshida A, Chitnis N, Altman BJ, Tameire F, Oran A, Gennaro V, Armeson KE, McMahon SB, Wertheim GB, Dang CV, Ruggero D, Koumenis C, Fuchs SY, Diehl JA. A PERK-miR-211 axis suppresses circadian regulators and protein synthesis to promote cancer cell survival. Nature Cell Biology. PMID 29230015 DOI: 10.1038/S41556-017-0006-Y |
0.381 |
|
2017 |
Velalopoulou A, Chatterjee S, Pietrofesa RA, Koziol-White C, Panettieri RA, Lin L, Tuttle S, Berman A, Koumenis C, Christofidou-Solomidou M. Synthetic Secoisolariciresinol Diglucoside (LGM2605) Protects Human Lung in an Ex Vivo Model of Proton Radiation Damage. International Journal of Molecular Sciences. 18. PMID 29186841 DOI: 10.3390/Ijms18122525 |
0.318 |
|
2017 |
Brady LK, Wang H, Radens CM, Bi Y, Radovich M, Maity A, Ivan C, Ivan M, Barash Y, Koumenis C. Transcriptome analysis of hypoxic cancer cells uncovers intron retention in EIF2B5 as a mechanism to inhibit translation. Plos Biology. 15: e2002623. PMID 28961236 DOI: 10.1371/Journal.Pbio.2002623 |
0.432 |
|
2017 |
Katlinski KV, Gui J, Katlinskaya YV, Ortiz A, Chakraborty R, Bhattacharya S, Carbone CJ, Beiting DP, Girondo MA, Peck AR, Puré E, Chatterji P, Rustgi AK, Diehl JA, Koumenis C, et al. Inactivation of Interferon Receptor Promotes the Establishment of Immune Privileged Tumor Microenvironment. Cancer Cell. 31: 194-207. PMID 28196594 DOI: 10.1016/J.Ccell.2017.01.004 |
0.382 |
|
2017 |
Bi Y, Verginadis I, Dey S, Guo l, Lin L, Zheng Y, Koumenis C. Abstract 5863: Identifying the radiosensitizing effects of PARP inhibitor in ovarian cancer Cancer Research. 77: 5863-5863. DOI: 10.1158/1538-7445.Am2017-5863 |
0.422 |
|
2017 |
Verginadis I, Encarnación J, Dey S, Koumenis C. Abstract 4500: Inhibition of PERK by small molecule inhibitors enhances the response to ionizing radiation in vitro and animal tumor models Cancer Research. 77: 4500-4500. DOI: 10.1158/1538-7445.Am2017-4500 |
0.375 |
|
2017 |
Brady LK, Wang H, Radens C, Radovich M, Maity A, Ivan C, Ivan M, Barash Y, Koumenis C. Abstract 1998: Transcriptome analysis of hypoxic head and neck cancer cells uncovers intron retention in EIF2B5 as a mechanism to reduce protein synthesis Cancer Research. 77: 1998-1998. DOI: 10.1158/1538-7445.Am2017-1998 |
0.354 |
|
2017 |
Leli NM, Dey S, Brady L, Koumenis C. Abstract 1247: Identifying novel regulators of the Unfolded Protein Response (UPR) by genome-scale CRISPR-Cas9 knockout screens Cancer Research. 77: 1247-1247. DOI: 10.1158/1538-7445.Am2017-1247 |
0.486 |
|
2016 |
Verginadis II, Kanade R, Bell B, Koduri S, Ben-Josef E, Koumenis C. A novel mouse model to study image-guided, radiation-induced intestinal injury and preclinical screening of radioprotectors. Cancer Research. PMID 28011621 DOI: 10.1158/0008-5472.Can-16-2724 |
0.314 |
|
2016 |
Brady LK, Popov V, Koumenis C. In Vivo Interrogation of the Hypoxic Transcriptome of Solid Tumors: Optimizing Hypoxic Probe Labeling with Laser Capture Microdissection for Isolation of High-Quality RNA for Deep Sequencing Analysis. Advances in Experimental Medicine and Biology. 899: 41-58. PMID 27325261 DOI: 10.1007/978-3-319-26666-4_4 |
0.336 |
|
2016 |
Pietrofesa RA, Velalopoulou A, Lehman SL, Arguiri E, Solomides P, Koch CJ, Mishra OP, Koumenis C, Goodwin TJ, Christofidou-Solomidou M. Novel Double-Hit Model of Radiation and Hyperoxia-Induced Oxidative Cell Damage Relevant to Space Travel. International Journal of Molecular Sciences. 17. PMID 27322243 DOI: 10.3390/Ijms17060953 |
0.366 |
|
2016 |
Shah S, Carriveau WJ, Li J, Campbell SL, Kopinski PK, Lim HW, Daurio N, Trefely S, Won KJ, Wallace DC, Koumenis C, Mancuso A, Wellen KE. Targeting ACLY sensitizes castration-resistant prostate cancer cells to AR antagonism by impinging on an ACLY-AMPK-AR feedback mechanism. Oncotarget. PMID 27248322 DOI: 10.18632/Oncotarget.9666 |
0.35 |
|
2016 |
Katlinskaya YV, Katlinski KV, Yu Q, Ortiz A, Beiting DP, Brice A, Davar D, Sanders C, Kirkwood JM, Rui H, Xu X, Koumenis C, Diehl JA, Fuchs SY. Suppression of Type I Interferon Signaling Overcomes Oncogene-Induced Senescence and Mediates Melanoma Development and Progression. Cell Reports. PMID 27052162 DOI: 10.1016/J.Celrep.2016.03.006 |
0.394 |
|
2016 |
Huang M, Liu T, Ma P, Mitteer RA, Zhang Z, Kim HJ, Yeo E, Zhang D, Cai P, Li C, Zhang L, Zhao B, Roccograndi L, O'Rourke DM, Dahmane N, ... ... Koumenis C, et al. c-Met-mediated endothelial plasticity drives aberrant vascularization and chemoresistance in glioblastoma. The Journal of Clinical Investigation. PMID 27043280 DOI: 10.1172/Jci84876 |
0.368 |
|
2016 |
Daurio NA, Tuttle SW, Worth AJ, Song EY, Davis JM, Snyder NW, Blair IA, Koumenis C. AMPK activation and metabolic reprogramming by tamoxifen through estrogen receptor-independent mechanisms suggests new uses for this therapeutic modality in cancer treatment. Cancer Research. PMID 27020861 DOI: 10.1158/0008-5472.Can-15-2197 |
0.409 |
|
2016 |
Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD, Adeli K, Adhihetty PJ, Adler SG, Agam G, Agarwal R, Aghi MK, ... ... Koumenis C, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 12: 1-222. PMID 26799652 DOI: 10.1080/15548627.2015.1100356 |
0.325 |
|
2016 |
Brady LK, Shekher R, Popov V, Ivan M, Radovich M, Koumenis C. Abstract 733: Analysis of the hypoxic transcriptome in cells and solid tumors reveals a novel spliced isoform of the key regulator of mRNA translation, eIF2B5 Cancer Research. 76: 733-733. DOI: 10.1158/1538-7445.Am2016-733 |
0.445 |
|
2016 |
Tameire F, Monroy MA, Koumenis C. Abstract 230: The role of integrated stress response (ISR) transcription factor ATF4 in metabolic adaptation of tumors to c-Myc activation Cancer Research. 76: 230-230. DOI: 10.1158/1538-7445.Am2016-230 |
0.455 |
|
2016 |
Verginadis I, Kanade R, Ben-Josef E, Koumenis C. Abstract 1662: Development of a novel mouse model to study image-guided radiation-induced gastrointestinal injury and its application in pre-clinical research Cancer Research. 76: 1662-1662. DOI: 10.1158/1538-7445.Am2016-1662 |
0.353 |
|
2015 |
Yu Q, Zhao B, Gui J, Katlinski KV, Brice A, Gao Y, Li C, Kushner JA, Koumenis C, Diehl JA, Fuchs SY. Type I interferons mediate pancreatic toxicities of PERK inhibition. Proceedings of the National Academy of Sciences of the United States of America. PMID 26627716 DOI: 10.1073/Pnas.1516362112 |
0.321 |
|
2015 |
Ye J, Palm W, Peng M, King B, Lindsten T, Li MO, Koumenis C, Thompson CB. GCN2 sustains mTORC1 suppression upon amino acid deprivation by inducing Sestrin2. Genes & Development. PMID 26543160 DOI: 10.1101/Gad.269324.115 |
0.362 |
|
2015 |
Lehman SL, Ryeom S, Koumenis C. Signaling through alternative Integrated Stress Response pathways compensates for GCN2 loss in a mouse model of soft tissue sarcoma. Scientific Reports. 5: 11781. PMID 26123823 DOI: 10.1038/Srep11781 |
0.441 |
|
2015 |
Lehman SL, Cerniglia GJ, Johannes GJ, Ye J, Ryeom S, Koumenis C. Translational Upregulation of an Individual p21Cip1 Transcript Variant by GCN2 Regulates Cell Proliferation and Survival under Nutrient Stress. Plos Genetics. 11: e1005212. PMID 26102367 DOI: 10.1371/Journal.Pgen.1005212 |
0.389 |
|
2015 |
Dey S, Sayers CM, Verginadis II, Lehman SL, Cheng Y, Cerniglia GJ, Tuttle SW, Feldman MD, Zhang PJ, Fuchs SY, Diehl JA, Koumenis C. ATF4-dependent induction of heme oxygenase 1 prevents anoikis and promotes metastasis. The Journal of Clinical Investigation. 125: 2592-608. PMID 26011642 DOI: 10.1172/Jci78031 |
0.455 |
|
2015 |
Cerniglia GJ, Dey S, Gallagher-Colombo SM, Daurio NA, Tuttle S, Busch TM, Lin A, Sun R, Esipova TV, Vinogradov SA, Denko N, Koumenis C, Maity A. The PI3K/Akt Pathway Regulates Oxygen Metabolism via Pyruvate Dehydrogenase (PDH)-E1α Phosphorylation. Molecular Cancer Therapeutics. 14: 1928-38. PMID 25995437 DOI: 10.1158/1535-7163.Mct-14-0888 |
0.425 |
|
2015 |
Tameire F, Verginadis II, Koumenis C. Cell intrinsic and extrinsic activators of the unfolded protein response in cancer: Mechanisms and targets for therapy. Seminars in Cancer Biology. 33: 3-15. PMID 25920797 DOI: 10.1016/J.Semcancer.2015.04.002 |
0.41 |
|
2015 |
Cerniglia G, Dey S, Gallagher-Colombo SM, Daurio N, Tuttle S, Busch TM, Lin A, Esipova TV, Vinogradov S, Koumenis C, Maity A. Abstract B05: PI3K/mTOR pathway-dependent regulation of oxygen metabolism via pyruvate dehydrogenase (PDH)-E1alpha phosphorylation Molecular Cancer Therapeutics. 14. DOI: 10.1158/1538-8514.Pi3K14-B05 |
0.434 |
|
2015 |
Daurio NA, Tuttle S, Koumenis C. Abstract 5510: Tamoxifen induces estrogen receptor-independent bioenergetic stress: A synthetic lethality approach to target tumor metabolism Cancer Research. 75: 5510-5510. DOI: 10.1158/1538-7445.Am2015-5510 |
0.411 |
|
2015 |
Brady L, Popov V, Ivan M, Radovich M, Koumenis C. Abstract 3005: Investigating the impact of hypoxia-induced changes in splicing on tumor microenvironment Cancer Research. 75: 3005-3005. DOI: 10.1158/1538-7445.Am2015-3005 |
0.447 |
|
2015 |
Dey S, Sayers CM, Lehman SL, Cheng Y, Cerniglia GJ, Tuttle SW, Feldman MD, Zhang PJL, Fuchs SY, Diehl JA, Koumenis C. Abstract 1262: The transcription factor ATF4 regulates resistance to anoikis and promotes metastasis in fibrosarcoma via cooperative upregulation of Heme Oxygenase-1 with Nrf2 Cancer Research. 75: 1262-1262. DOI: 10.1158/1538-7445.Am2015-1262 |
0.471 |
|
2015 |
Cerniglia GJ, Day S, Gallagher-Colombo SM, Daurio N, Tuttle S, Busch TM, Lin A, Esipova TV, Vinogradov SA, Koumenis C, Maity A. Abstract 1140: PI3K/Akt inhibition decreases oxygen consumption In tumor cells by phosphorylating and inactivating pyruvate dehydrogenase PDH E1α subunit Cancer Research. 75: 1140-1140. DOI: 10.1158/1538-7445.Am2015-1140 |
0.437 |
|
2014 |
Koumenis C, Hammond E, Giaccia A. Tumor microenvironment and cellular stress: signaling, metabolism, imaging, and therapeutic targets. Preface. Advances in Experimental Medicine and Biology. 772: v-viii. PMID 24765667 DOI: 10.1007/978-1-4614-5915-6 |
0.428 |
|
2014 |
Ma XH, Piao SF, Dey S, McAfee Q, Karakousis G, Villanueva J, Hart LS, Levi S, Hu J, Zhang G, Lazova R, Klump V, Pawelek JM, Xu X, Xu W, ... ... Koumenis C, et al. Targeting ER stress-induced autophagy overcomes BRAF inhibitor resistance in melanoma. The Journal of Clinical Investigation. 124: 1406-17. PMID 24569374 DOI: 10.1172/Jci70454 |
0.426 |
|
2014 |
Lehman SL, Ye J, Koumenis C. Abstract 487: The Integrated Stress Response kinase GCN2 regulates cell proliferation and survival through combined transcriptional and translational control of p21 (Cip1/Waf1) Cancer Research. 74: 487-487. DOI: 10.1158/1538-7445.Am2014-487 |
0.461 |
|
2013 |
Guttmann DM, Hart L, Du K, Seletsky A, Koumenis C. Inhibition of Hsp27 radiosensitizes head-and-neck cancer by modulating deoxyribonucleic acid repair. International Journal of Radiation Oncology, Biology, Physics. 87: 168-75. PMID 23849696 DOI: 10.1016/J.Ijrobp.2013.05.028 |
0.323 |
|
2013 |
Dey S, Tameire F, Koumenis C. PERK-ing up autophagy during MYC-induced tumorigenesis. Autophagy. 9: 612-4. PMID 23328692 DOI: 10.4161/Auto.23486 |
0.478 |
|
2013 |
Sayers CM, Papandreou I, Guttmann DM, Maas NL, Diehl JA, Witze ES, Koong AC, Koumenis C. Identification and characterization of a potent activator of p53-independent cellular senescence via a small-molecule screen for modifiers of the integrated stress response. Molecular Pharmacology. 83: 594-604. PMID 23229510 DOI: 10.1124/Mol.112.081810 |
0.456 |
|
2013 |
Koumenis C, Hart LS, Cunningham T, Dey S, Tameire F, Mills I, Ruggero D, Diehl AJ, Fuchs S. Abstract SY32-04: The translation initiation factor elF2α regulates cytoprotective autophagy in Myc-dependent lymphoma. Cancer Research. 73. DOI: 10.1158/1538-7445.Am2013-Sy32-04 |
0.523 |
|
2013 |
Lehman SL, Ye J, Koumenis C. Abstract 570: The integrated stress response kinase GCN2 regulates cell survival through p21/WAF1/CIP1 in response to nutrient deprivation. Cancer Research. 73: 570-570. DOI: 10.1158/1538-7445.Am2013-570 |
0.456 |
|
2013 |
Daurio N, Tuttle S, Sood N, Hammer D, Koumenis C. Abstract 4527: Sensitization of cancer cells to cisplatin by curcumin: mlecular mechanism and drug delivery. Cancer Research. 73: 4527-4527. DOI: 10.1158/1538-7445.Am2013-4527 |
0.372 |
|
2013 |
Dey S, Sayers CM, Koumenis C. Abstract 2934: Activation of the Integrated Stress Response target ATF4 provides resistance towards anoikis- mediated cell death and promotes metastasis. Cancer Research. 73: 2934-2934. DOI: 10.1158/1538-7445.Am2013-2934 |
0.497 |
|
2013 |
Tameire F, Hart LS, Qiu B, Koumenis C. Abstract 1689: The cytoprotective role of the UPR during c-Myc dependent transformation and tumor progression. Cancer Research. 73: 1689-1689. DOI: 10.1158/1538-7445.Am2013-1689 |
0.442 |
|
2013 |
Cerniglia GJ, Daurio N, Gallagher-Colombo SM, Busch TM, Tuttle SW, Koch CJ, Lin A, Koumenis C, Maity A. Abstract 1037: Agents that target the PI3K/mTOR pathway decrease oxygen consumption, reduce tumor hypoxia and improve radiation response in solid tumors. Cancer Research. 73: 1037-1037. DOI: 10.1158/1538-7445.Am2013-1037 |
0.425 |
|
2012 |
Hart LS, Cunningham JT, Datta T, Dey S, Tameire F, Lehman SL, Qiu B, Zhang H, Cerniglia G, Bi M, Li Y, Gao Y, Liu H, Li C, Maity A, ... ... Koumenis C, et al. ER stress-mediated autophagy promotes Myc-dependent transformation and tumor growth. The Journal of Clinical Investigation. 122: 4621-34. PMID 23143306 DOI: 10.1172/Jci62973 |
0.452 |
|
2012 |
Chitnis NS, Pytel D, Bobrovnikova-Marjon E, Pant D, Zheng H, Maas NL, Frederick B, Kushner JA, Chodosh LA, Koumenis C, Fuchs SY, Diehl JA. miR-211 is a prosurvival microRNA that regulates chop expression in a PERK-dependent manner. Molecular Cell. 48: 353-64. PMID 23022383 DOI: 10.1016/J.Molcel.2012.08.025 |
0.308 |
|
2012 |
Cerniglia GJ, Karar J, Tyagi S, Christofidou-Solomidou M, Rengan R, Koumenis C, Maity A. Inhibition of autophagy as a strategy to augment radiosensitization by the dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor NVP-BEZ235. Molecular Pharmacology. 82: 1230-40. PMID 22989521 DOI: 10.1124/Mol.112.080408 |
0.426 |
|
2012 |
Karar J, Cerniglia GJ, Lindsten T, Koumenis C, Maity A. Dual PI3K/mTOR inhibitor NVP-BEZ235 suppresses hypoxia-inducible factor (HIF)-1α expression by blocking protein translation and increases cell death under hypoxia. Cancer Biology & Therapy. 13: 1102-11. PMID 22895065 DOI: 10.4161/Cbt.21144 |
0.449 |
|
2012 |
Tuttle S, Hertan L, Daurio N, Porter S, Kaushick C, Li D, Myamoto S, Lin A, O'Malley BW, Koumenis C. The chemopreventive and clinically used agent curcumin sensitizes HPV (-) but not HPV (+) HNSCC to ionizing radiation, in vitro and in a mouse orthotopic model. Cancer Biology & Therapy. 13: 575-84. PMID 22441776 DOI: 10.4161/Cbt.19772 |
0.33 |
|
2012 |
Tang X, Lucas JE, Chen JL, LaMonte G, Wu J, Wang MC, Koumenis C, Chi JT. Functional interaction between responses to lactic acidosis and hypoxia regulates genomic transcriptional outputs. Cancer Research. 72: 491-502. PMID 22135092 DOI: 10.1158/0008-5472.Can-11-2076 |
0.457 |
|
2012 |
Sayers CM, Koong AC, Koumenis C. Abstract 4994: An integrated stress response activator causes cellular senescence and inhibits growth in multiple tumor cell types Cancer Research. 72: 4994-4994. DOI: 10.1158/1538-7445.Am2012-4994 |
0.466 |
|
2012 |
Cerniglia GJ, Karar J, Koumenis C, Maity A. Abstract 2804: Radiosensitization by the Dual PI3K/mTOR inhibitor NVP-BEZ235 Cancer Research. 72: 2804-2804. DOI: 10.1158/1538-7445.Am2012-2804 |
0.416 |
|
2012 |
Karar J, Cerniglia GJ, Koumenis C, Maity A. Abstract 2800: Dual PI3K/mTOR inhibitor NVP BEZ-235 suppresses translation of hypoxia-inducible factor (HIF)-1α and increases cell death under hypoxia Cancer Research. 72: 2800-2800. DOI: 10.1158/1538-7445.Am2012-2800 |
0.441 |
|
2012 |
Maity A, Cerniglia GJ, Karar J, Koumenis C. Inhibition of Autophagy as a Strategy to Augment Radiosensitization by the Dual PI3K/mTOR Inhibitor NVP-BEZ235 International Journal of Radiation Oncology Biology Physics. 84. DOI: 10.1016/J.Ijrobp.2012.07.130 |
0.315 |
|
2011 |
Guttmann DM, Koumenis C. The heat shock proteins as targets for radiosensitization and chemosensitization in cancer. Cancer Biology & Therapy. 12: 1023-31. PMID 22236878 DOI: 10.4161/Cbt.12.12.18374 |
0.377 |
|
2011 |
Stewart RD, Yu VK, Georgakilas AG, Koumenis C, Park JH, Carlson DJ. Effects of radiation quality and oxygen on clustered DNA lesions and cell death. Radiation Research. 176: 587-602. PMID 21823972 DOI: 10.1667/Rr2663.1 |
0.316 |
|
2011 |
Hart LS, Dolloff NG, Dicker DT, Koumenis C, Christensen JG, Grimberg A, El-Deiry WS. Human colon cancer stem cells are enriched by insulin-like growth factor-1 and are sensitive to figitumumab. Cell Cycle (Georgetown, Tex.). 10: 2331-8. PMID 21720213 DOI: 10.4161/Cc.10.14.16418 |
0.373 |
|
2011 |
Tian X, Ye J, Alonso-Basanta M, Hahn SM, Koumenis C, Dorsey JF. Modulation of CCAAT/enhancer binding protein homologous protein (CHOP)-dependent DR5 expression by nelfinavir sensitizes glioblastoma multiforme cells to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL). The Journal of Biological Chemistry. 286: 29408-16. PMID 21697087 DOI: 10.1074/Jbc.M110.197665 |
0.439 |
|
2011 |
Bhattacharya S, Qian J, Tzimas C, Baker DP, Koumenis C, Diehl JA, Fuchs SY. Role of p38 protein kinase in the ligand-independent ubiquitination and down-regulation of the IFNAR1 chain of type I interferon receptor. The Journal of Biological Chemistry. 286: 22069-76. PMID 21540188 DOI: 10.1074/Jbc.M111.238766 |
0.375 |
|
2011 |
Marotta D, Karar J, Jenkins WT, Kumanova M, Jenkins KW, Tobias JW, Baldwin D, Hatzigeorgiou A, Alexiou P, Evans SM, Alarcon R, Maity A, Koch C, Koumenis C. In vivo profiling of hypoxic gene expression in gliomas using the hypoxia marker EF5 and laser-capture microdissection. Cancer Research. 71: 779-89. PMID 21266355 DOI: 10.1158/0008-5472.Can-10-3061 |
0.422 |
|
2011 |
Koumenis C, Zhang H, Bi M, Lehman SL, Datta T, Liu H, Thomas-Tikhonenko A, Koong A, Fuchs SY, Diehl JA, Ruggero D. Abstract SY06-02: Activation of the UPR by c-Myc promotes transformation and tumorigenesis via cytoprotective autophagy Cancer Research. 71. DOI: 10.1158/1538-7445.Am2011-Sy06-02 |
0.483 |
|
2011 |
Karar J, Marotta D, Jenkins WT, Kumanova M, Jenkins K, Tobias JW, Baldwin D, Hatzigeorgiou A, Alexiou P, Evans SM, Alarcon R, Koch C, Maity A, Koumenis C. Abstract 5004:In vivoprofiling of hypoxic mRNA and miRNA expression in gliomas and head and neck tumors Cancer Research. 71: 5004-5004. DOI: 10.1158/1538-7445.Am2011-5004 |
0.384 |
|
2011 |
Welliver MX, Hart LS, Ye J, Lu C, Mick R, Kong M, Ditsworth D, Mesina A, Zhao F, Guerriero JL, Zong W, Koumenis C, Thompson CB. Abstract 2513: Molecular dissection of cell death mechanisms following ionizing radiationin vitroandin vivo Cancer Research. 71: 2513-2513. DOI: 10.1158/1538-7445.Am2011-2513 |
0.459 |
|
2011 |
Hart LS, Cunningham T, Datta T, Liu H, Koong AC, Fuchs S, Diehl JA, Ruggero D, Koumenis C. Abstract 2078: PERK-mediated autophagy promotes Myc-induced transformation and tumorigenesis Cancer Research. 71: 2078-2078. DOI: 10.1158/1538-7445.Am2011-2078 |
0.471 |
|
2011 |
Lehman SL, Sayers CM, Ye J, Hart LS, Ayeni DO, Koong A, Koumenis C. Abstract 2072: The role of the integrated stress response proteins GCN2 and ATF4 in autophagy and tumor migration Cancer Research. 71: 2072-2072. DOI: 10.1158/1538-7445.Am2011-2072 |
0.451 |
|
2010 |
Maity A, Koumenis C. Location, location, location-makes all the difference for hypoxia in lung tumors. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 16: 4685-7. PMID 20858842 DOI: 10.1158/1078-0432.Ccr-10-2004 |
0.361 |
|
2010 |
Ye J, Kumanova M, Hart LS, Sloane K, Zhang H, De Panis DN, Bobrovnikova-Marjon E, Diehl JA, Ron D, Koumenis C. The GCN2-ATF4 pathway is critical for tumour cell survival and proliferation in response to nutrient deprivation. The Embo Journal. 29: 2082-96. PMID 20473272 DOI: 10.1038/Emboj.2010.81 |
0.419 |
|
2010 |
Bobrovnikova-Marjon E, Grigoriadou C, Pytel D, Zhang F, Ye J, Koumenis C, Cavener D, Diehl JA. PERK promotes cancer cell proliferation and tumor growth by limiting oxidative DNA damage. Oncogene. 29: 3881-95. PMID 20453876 DOI: 10.1038/Onc.2010.153 |
0.468 |
|
2010 |
Lee JC, Kinniry PA, Arguiri E, Serota M, Kanterakis S, Chatterjee S, Solomides CC, Javvadi P, Koumenis C, Cengel KA, Christofidou-Solomidou M. Dietary curcumin increases antioxidant defenses in lung, ameliorates radiation-induced pulmonary fibrosis, and improves survival in mice. Radiation Research. 173: 590-601. PMID 20426658 DOI: 10.1667/Rr1522.1 |
0.329 |
|
2010 |
Lehman S, Koumenis C. The role of autophagy as a mechanism of cytotoxicity by the clinically used agent MDA-7/IL-24. Cancer Biology & Therapy. 9: 537-8. PMID 20234182 DOI: 10.4161/Cbt.9.7.11381 |
0.338 |
|
2010 |
Javvadi P, Hertan L, Kosoff R, Datta T, Kolev J, Mick R, Tuttle SW, Koumenis C. Thioredoxin reductase-1 mediates curcumin-induced radiosensitization of squamous carcinoma cells. Cancer Research. 70: 1941-50. PMID 20160040 DOI: 10.1158/0008-5472.Can-09-3025 |
0.453 |
|
2010 |
Bhattacharya S, HuangFu WC, Liu J, Veeranki S, Baker DP, Koumenis C, Diehl JA, Fuchs SY. Inducible priming phosphorylation promotes ligand-independent degradation of the IFNAR1 chain of type I interferon receptor. The Journal of Biological Chemistry. 285: 2318-25. PMID 19948722 DOI: 10.1074/Jbc.M109.071498 |
0.328 |
|
2009 |
Ye J, Koumenis C. ATF4, an ER stress and hypoxia-inducible transcription factor and its potential role in hypoxia tolerance and tumorigenesis. Current Molecular Medicine. 9: 411-6. PMID 19519398 DOI: 10.2174/156652409788167096 |
0.461 |
|
2009 |
Hertan LM, Koumenis C. Piling up the JNK: drug synergy through ER stress. Cancer Biology & Therapy. 8: 820-2. PMID 19458484 DOI: 10.4161/Cbt.8.9.8403 |
0.332 |
|
2008 |
Little JL, Wheeler FB, Koumenis C, Kridel SJ. Disruption of crosstalk between the fatty acid synthesis and proteasome pathways enhances unfolded protein response signaling and cell death. Molecular Cancer Therapeutics. 7: 3816-24. PMID 19074856 DOI: 10.1158/1535-7163.Mct-08-0558 |
0.446 |
|
2008 |
Fels DR, Ye J, Segan AT, Kridel SJ, Spiotto M, Olson M, Koong AC, Koumenis C. Preferential cytotoxicity of bortezomib toward hypoxic tumor cells via overactivation of endoplasmic reticulum stress pathways. Cancer Research. 68: 9323-30. PMID 19010906 DOI: 10.1158/0008-5472.Can-08-2873 |
0.491 |
|
2008 |
Park MA, Yacoub A, Sarkar D, Emdad L, Rahmani M, Spiegel S, Koumenis C, Graf M, Curiel DT, Grant S, Fisher PB, Dent P. PERK-dependent regulation of MDA-7/IL-24-induced autophagy in primary human glioma cells. Autophagy. 4: 513-5. PMID 18299661 DOI: 10.4161/Auto.5725 |
0.462 |
|
2008 |
Javvadi P, Segan AT, Tuttle SW, Koumenis C. The chemopreventive agent curcumin is a potent radiosensitizer of human cervical tumor cells via increased reactive oxygen species production and overactivation of the mitogen-activated protein kinase pathway. Molecular Pharmacology. 73: 1491-501. PMID 18252805 DOI: 10.1124/Mol.107.043554 |
0.436 |
|
2008 |
Park MA, Curiel DT, Koumenis C, Graf M, Chen CS, Fisher PB, Grant S, Dent P. PERK-dependent regulation of HSP70 expression and the regulation of autophagy. Autophagy. 4: 364-7. PMID 18216498 DOI: 10.4161/Auto.5593 |
0.39 |
|
2008 |
Schwartz GG, Eads D, Naczki C, Northrup S, Chen T, Koumenis C. 19-nor-1α,25-dihydroxyvitamin D2 (Paricalcitol) inhibits the proliferation of human pancreatic cancer cells in vitro and in vivo Cancer Biology and Therapy. 7: 430-436. PMID 18094617 DOI: 10.4161/Cbt.7.3.5418 |
0.403 |
|
2007 |
Koumenis C, Bi M, Ye J, Feldman D, Koong AC. Hypoxia and the Unfolded Protein Response Methods in Enzymology. 435: 275-293. PMID 17998059 DOI: 10.1016/S0076-6879(07)35014-3 |
0.374 |
|
2007 |
Lally BE, Geiger GA, Kridel S, Arcury-Quandt AE, Robbins ME, Kock ND, Wheeler K, Peddi P, Georgakilas A, Kao GD, Koumenis C. Identification and biological evaluation of a novel and potent small molecule radiation sensitizer via an unbiased screen of a chemical library. Cancer Research. 67: 8791-9. PMID 17875720 DOI: 10.1158/0008-5472.Can-07-0477 |
0.423 |
|
2007 |
Little JL, Wheeler FB, Fels DR, Koumenis C, Kridel SJ. Inhibition of fatty acid synthase induces endoplasmic reticulum stress in tumor cells. Cancer Research. 67: 1262-9. PMID 17283163 DOI: 10.1158/0008-5472.Can-06-1794 |
0.478 |
|
2007 |
Hart LS, Ornelles D, Koumenis C. The adenoviral E4orf6 protein induces atypical apoptosis in response to DNA damage. The Journal of Biological Chemistry. 282: 6061-7. PMID 17172468 DOI: 10.1074/Jbc.M610405200 |
0.397 |
|
2006 |
Fels DR, Koumenis C. The PERK/eIF2alpha/ATF4 module of the UPR in hypoxia resistance and tumor growth. Cancer Biology & Therapy. 5: 723-8. PMID 16861899 DOI: 10.4161/Cbt.5.7.2967 |
0.477 |
|
2006 |
Koumenis C, Wouters BG. "Translating" tumor hypoxia: unfolded protein response (UPR)-dependent and UPR-independent pathways. Molecular Cancer Research : McR. 4: 423-36. PMID 16849518 DOI: 10.1158/1541-7786.Mcr-06-0150 |
0.478 |
|
2006 |
Koumenis C, Maxwell PH. Low oxygen stimulates the intellect. Symposium on hypoxia and development, physiology and disease. Embo Reports. 7: 679-84. PMID 16799463 DOI: 10.1038/Sj.Embor.7400733 |
0.348 |
|
2006 |
Monjazeb AM, High KP, Connoy A, Hart LS, Koumenis C, Chilton FH. Arachidonic acid-induced gene expression in colon cancer cells. Carcinogenesis. 27: 1950-60. PMID 16704987 DOI: 10.1093/Carcin/Bgl023 |
0.426 |
|
2006 |
Koumenis C. ER stress, hypoxia tolerance and tumor progression. Current Molecular Medicine. 6: 55-69. PMID 16472113 DOI: 10.2174/156652406775574604 |
0.489 |
|
2006 |
Koritzinsky M, Magagnin MG, van den Beucken T, Seigneuric R, Savelkouls K, Dostie J, Pyronnet S, Kaufman RJ, Weppler SA, Voncken JW, Lambin P, Koumenis C, Sonenberg N, Wouters BG. Gene expression during acute and prolonged hypoxia is regulated by distinct mechanisms of translational control. The Embo Journal. 25: 1114-25. PMID 16467844 DOI: 10.1038/Sj.Emboj.7600998 |
0.377 |
|
2005 |
Monjazeb AM, High KP, Koumenis C, Chilton FH. Inhibitors of arachidonic acid metabolism act synergistically to signal apoptosis in neoplastic cells. Prostaglandins, Leukotrienes, and Essential Fatty Acids. 73: 463-74. PMID 16169197 DOI: 10.1016/J.Plefa.2005.07.009 |
0.419 |
|
2005 |
Bi M, Naczki C, Koritzinsky M, Fels D, Blais J, Hu N, Harding H, Novoa I, Varia M, Raleigh J, Scheuner D, Kaufman RJ, Bell J, Ron D, Wouters BG, ... Koumenis C, et al. ER stress-regulated translation increases tolerance to extreme hypoxia and promotes tumor growth. The Embo Journal. 24: 3470-81. PMID 16148948 DOI: 10.1038/Sj.Emboj.7600777 |
0.475 |
|
2005 |
Wouters BG, van den Beucken T, Magagnin MG, Koritzinsky M, Fels D, Koumenis C. Control of the hypoxic response through regulation of mRNA translation. Seminars in Cell & Developmental Biology. 16: 487-501. PMID 15896987 DOI: 10.1016/J.Semcdb.2005.03.009 |
0.456 |
|
2005 |
Hart LS, Yannone SM, Naczki C, Orlando JS, Waters SB, Akman SA, Chen DJ, Ornelles D, Koumenis C. The adenovirus E4orf6 protein inhibits DNA double strand break repair and radiosensitizes human tumor cells in an E1B-55K-independent manner. The Journal of Biological Chemistry. 280: 1474-81. PMID 15507430 DOI: 10.1074/Jbc.M409934200 |
0.378 |
|
2004 |
Schwartz GG, Eads D, Rao A, Cramer SD, Willingham MC, Chen TC, Jamieson DP, Wang L, Burnstein KL, Holick MF, Koumenis C. Pancreatic cancer cells express 25-hydroxyvitamin D-1 alpha-hydroxylase and their proliferation is inhibited by the prohormone 25-hydroxyvitamin D3. Carcinogenesis. 25: 1015-26. PMID 14742320 DOI: 10.1093/Carcin/Bgh086 |
0.335 |
|
2002 |
Koumenis C, Naczki C, Koritzinsky M, Rastani S, Diehl A, Sonenberg N, Koromilas A, Wouters BG. Regulation of protein synthesis by hypoxia via activation of the endoplasmic reticulum kinase PERK and phosphorylation of the translation initiation factor eIF2alpha. Molecular and Cellular Biology. 22: 7405-16. PMID 12370288 DOI: 10.1128/Mcb.22.21.7405-7416.2002 |
0.442 |
|
2002 |
Parks GD, Young VA, Koumenis C, Wansley EK, Layer JL, Cooke KM. Controlled cell killing by a recombinant nonsegmented negative-strand RNA virus. Virology. 293: 192-203. PMID 11853412 DOI: 10.1006/Viro.2001.1298 |
0.338 |
|
2001 |
Koumenis C, Alarcon R, Hammond E, Sutphin P, Hoffman W, Murphy M, Derr J, Taya Y, Lowe SW, Kastan M, Giaccia A. Regulation of p53 by hypoxia: dissociation of transcriptional repression and apoptosis from p53-dependent transactivation. Molecular and Cellular Biology. 21: 1297-310. PMID 11158315 DOI: 10.1128/Mcb.21.4.1297-1310.2001 |
0.382 |
|
1998 |
Giaccia AJ, Brown JM, Wouters B, Denko N, Koumenis C. Cancer therapy and tumor physiology. Science (New York, N.Y.). 279: 12-3. PMID 9441397 DOI: 10.1126/Science.279.5347.10E |
0.429 |
|
1998 |
Marquez SD, Derr J, Koumenis C, Giaccia AJ. Bax protein is not involved in hypoxia-induced apoptosis International Journal of Radiation Oncology*Biology*Physics. 42: 136. DOI: 10.1016/S0360-3016(98)80125-9 |
0.341 |
|
1997 |
Koumenis C, Giaccia A. Transformed cells require continuous activity of RNA polymerase II to resist oncogene-induced apoptosis. Molecular and Cellular Biology. 17: 7306-16. PMID 9372962 DOI: 10.1128/Mcb.17.12.7306 |
0.402 |
|
1996 |
Fried LM, Koumenis C, Peterson SR, Green SL, van Zijl P, Allalunis-Turner J, Chen DJ, Fishel R, Giaccia AJ, Brown JM, Kirchgessner CU. The DNA damage response in DNA-dependent protein kinase-deficient SCID mouse cells: replication protein A hyperphosphorylation and p53 induction. Proceedings of the National Academy of Sciences of the United States of America. 93: 13825-30. PMID 8943020 DOI: 10.1073/Pnas.93.24.13825 |
0.318 |
|
1992 |
Koumenis C, Eskin A. The hunt for mechanisms of circadian timing in the eye of Aplysia. Chronobiology International. 9: 201-21. PMID 1611674 DOI: 10.3109/07420529209064530 |
0.324 |
|
Show low-probability matches. |