Gary K. Owens - Publications

University of Virginia, Charlottesville, VA 
Molecular Biology, Cell Biology, Oncology

122 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Newman AAC, Serbulea V, Baylis RA, Shankman LS, Bradley X, Alencar GF, Owsiany K, Deaton RA, Karnewar S, Shamsuzzaman S, Salamon A, Reddy MS, Guo L, Finn A, Virmani R, ... ... Owens GK, et al. Multiple cell types contribute to the atherosclerotic lesion fibrous cap by PDGFRβ and bioenergetic mechanisms. Nature Metabolism. 3: 166-181. PMID 33619382 DOI: 10.1038/s42255-020-00338-8  0.76
2020 Bulut GB, Alencar GF, Owsiany KM, Nguyen AT, Karnewar S, Haskins RM, Waller LK, Cherepanova OA, Deaton RA, Shankman LS, Keller SR, Owens GK. KLF4 (Kruppel-Like Factor 4)-Dependent Perivascular Plasticity Contributes to Adipose Tissue inflammation. Arteriosclerosis, Thrombosis, and Vascular Biology. ATVBAHA120314703. PMID 33054397 DOI: 10.1161/ATVBAHA.120.314703  0.76
2019 Cherepanova OA, Srikakulapu P, Greene ES, Chaklader M, Haskins RM, McCanna ME, Bandyopadhyay S, Ban B, Leitinger N, McNamara CA, Owens GK. Novel Autoimmune IgM Antibody Attenuates Atherosclerosis in IgM Deficient Low-Fat Diet-Fed, but Not Western Diet-Fed Mice. Arteriosclerosis, Thrombosis, and Vascular Biology. ATVBAHA119312771. PMID 31645128 DOI: 10.1161/Atvbaha.119.312771  0.64
2017 Murgai M, Ju W, Eason M, Kline J, Beury DW, Kaczanowska S, Miettinen MM, Kruhlak M, Lei H, Shern JF, Cherepanova OA, Owens GK, Kaplan RN. KLF4-dependent perivascular cell plasticity mediates pre-metastatic niche formation and metastasis. Nature Medicine. PMID 28920957 DOI: 10.1038/Nm.4400  0.6
2016 Cherepanova OA, Gomez D, Shankman LS, Swiatlowska P, Williams J, Sarmento OF, Alencar GF, Hess DL, Bevard MH, Greene ES, Murgai M, Turner SD, Geng YJ, Bekiranov S, Connelly JJ, ... ... Owens GK, et al. Activation of the pluripotency factor OCT4 in smooth muscle cells is atheroprotective. Nature Medicine. PMID 27183216 DOI: 10.1038/Nm.4109  0.48
2016 Bennett MR, Sinha S, Owens GK. Vascular Smooth Muscle Cells in Atherosclerosis. Circulation Research. 118: 692-702. PMID 26892967 DOI: 10.1161/Circresaha.115.306361  0.48
2015 Nurnberg ST, Cheng K, Raiesdana A, Kundu R, Miller CL, Kim JB, Arora K, Carcamo-Oribe I, Xiong Y, Tellakula N, Nanda V, Murthy N, Boisvert WA, Hedin U, Perisic L, ... ... Owens GK, et al. Coronary Artery Disease Associated Transcription Factor TCF21 Regulates Smooth Muscle Precursor Cells That Contribute to the Fibrous Cap. Plos Genetics. 11: e1005155. PMID 26020946 DOI: 10.1371/Journal.Pgen.1005155  0.48
2015 Shankman LS, Gomez D, Cherepanova OA, Salmon M, Alencar GF, Haskins RM, Swiatlowska P, Newman AA, Greene ES, Straub AC, Isakson B, Randolph GJ, Owens GK. KLF4-dependent phenotypic modulation of smooth muscle cells has a key role in atherosclerotic plaque pathogenesis. Nature Medicine. 21: 628-37. PMID 25985364 DOI: 10.1038/Nm.3866  0.48
2015 Tabas I, García-Cardeña G, Owens GK. Recent insights into the cellular biology of atherosclerosis. The Journal of Cell Biology. 209: 13-22. PMID 25869663 DOI: 10.1083/Jcb.201412052  0.48
2014 Johnston WF, Salmon M, Pope NH, Meher A, Su G, Stone ML, Lu G, Owens GK, Upchurch GR, Ailawadi G. Inhibition of interleukin-1β decreases aneurysm formation and progression in a novel model of thoracic aortic aneurysms. Circulation. 130: S51-9. PMID 25200056 DOI: 10.1161/Circulationaha.113.006800  0.48
2014 Starke RM, Chalouhi N, Jabbour PM, Tjoumakaris SI, Gonzalez LF, Rosenwasser RH, Wada K, Shimada K, Hasan DM, Greig NH, Owens GK, Dumont AS. Critical role of TNF-α in cerebral aneurysm formation and progression to rupture. Journal of Neuroinflammation. 11: 77. PMID 24739142 DOI: 10.1186/1742-2094-11-77  0.48
2014 Ding D, Starke RM, Dumont AS, Owens GK, Hasan DM, Chalouhi N, Medel R, Lin CL. Therapeutic implications of estrogen for cerebral vasospasm and delayed cerebral ischemia induced by aneurysmal subarachnoid hemorrhage. Biomed Research International. 2014: 727428. PMID 24724095 DOI: 10.1155/2014/727428  0.48
2014 Starke RM, Chalouhi N, Ding D, Raper DM, Mckisic MS, Owens GK, Hasan DM, Medel R, Dumont AS. Vascular smooth muscle cells in cerebral aneurysm pathogenesis. Translational Stroke Research. 5: 338-46. PMID 24323713 DOI: 10.1007/S12975-013-0290-1  0.48
2014 Starke RM, Raper DM, Ding D, Chalouhi N, Owens GK, Hasan DM, Medel R, Dumont AS. Tumor necrosis factor-α modulates cerebral aneurysm formation and rupture. Translational Stroke Research. 5: 269-77. PMID 24323710 DOI: 10.1007/S12975-013-0287-9  0.48
2013 Salmon M, Johnston WF, Woo A, Pope NH, Su G, Upchurch GR, Owens GK, Ailawadi G. KLF4 regulates abdominal aortic aneurysm morphology and deletion attenuates aneurysm formation. Circulation. 128: S163-74. PMID 24030402 DOI: 10.1161/Circulationaha.112.000238  0.48
2013 Starke RM, Ali MS, Jabbour PM, Tjoumakaris SI, Gonzalez F, Hasan DM, Rosenwasser RH, Owens GK, Koch WJ, Dumont AS. Cigarette smoke modulates vascular smooth muscle phenotype: implications for carotid and cerebrovascular disease. Plos One. 8: e71954. PMID 23967268 DOI: 10.1371/Journal.Pone.0071954  0.48
2013 Ali MS, Starke RM, Jabbour PM, Tjoumakaris SI, Gonzalez LF, Rosenwasser RH, Owens GK, Koch WJ, Greig NH, Dumont AS. TNF-α induces phenotypic modulation in cerebral vascular smooth muscle cells: implications for cerebral aneurysm pathology. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 33: 1564-73. PMID 23860374 DOI: 10.1038/Jcbfm.2013.109  0.48
2013 Murgai M, Thomas J, Cherepanova O, Delviks-Frankenberry K, Deeble P, Pathak VK, Rekosh D, Owens G. Xenotropic MLV envelope proteins induce tumor cells to secrete factors that promote the formation of immature blood vessels. Retrovirology. 10: 34. PMID 23537062 DOI: 10.1186/1742-4690-10-34  0.48
2013 Bhamidipati CM, Mehta GS, Moehle CW, Meher AK, Su G, Vigneshwar NG, Barbery C, Sharma AK, Kron IL, Laubach VE, Owens GK, Upchurch GR, Ailawadi G. Adenosine 2A receptor modulates inflammation and phenotype in experimental abdominal aortic aneurysms. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 27: 2122-31. PMID 23413358 DOI: 10.1096/Fj.12-214197  0.48
2013 Gomez D, Shankman LS, Nguyen AT, Owens GK. Detection of histone modifications at specific gene loci in single cells in histological sections. Nature Methods. 10: 171-7. PMID 23314172 DOI: 10.1038/Nmeth.2332  0.48
2013 Johnston WF, Salmon M, Su G, Lu G, Stone ML, Zhao Y, Owens GK, Upchurch GR, Ailawadi G. Genetic and pharmacologic disruption of interleukin-1β signaling inhibits experimental aortic aneurysm formation. Arteriosclerosis, Thrombosis, and Vascular Biology. 33: 294-304. PMID 23288154 DOI: 10.1161/Atvbaha.112.300432  0.48
2013 Leeper NJ, Raiesdana A, Kojima Y, Kundu RK, Cheng H, Maegdefessel L, Toh R, Ahn GO, Ali ZA, Anderson DR, Miller CL, Roberts SC, Spin JM, de Almeida PE, Wu JC, ... ... Owens GK, et al. Loss of CDKN2B promotes p53-dependent smooth muscle cell apoptosis and aneurysm formation. Arteriosclerosis, Thrombosis, and Vascular Biology. 33: e1-e10. PMID 23162013 DOI: 10.1161/Atvbaha.112.300399  0.48
2013 Nguyen AT, Gomez D, Bell RD, Campbell JH, Clowes AW, Gabbiani G, Giachelli CM, Parmacek MS, Raines EW, Rusch NJ, Speer MY, Sturek M, Thyberg J, Towler DA, Weiser-Evans MC, ... ... Owens GK, et al. Smooth muscle cell plasticity: fact or fiction? Circulation Research. 112: 17-22. PMID 23093573 DOI: 10.1161/Circresaha.112.281048  0.48
2012 Salmon M, Gomez D, Greene E, Shankman L, Owens GK. Cooperative binding of KLF4, pELK-1, and HDAC2 to a G/C repressor element in the SM22α promoter mediates transcriptional silencing during SMC phenotypic switching in vivo. Circulation Research. 111: 685-96. PMID 22811558 DOI: 10.1161/Circresaha.112.269811  0.48
2012 Gomez D, Owens GK. Smooth muscle cell phenotypic switching in atherosclerosis. Cardiovascular Research. 95: 156-64. PMID 22406749 DOI: 10.1093/Cvr/Cvs115  0.48
2012 Alexander MR, Murgai M, Moehle CW, Owens GK. Interleukin-1β modulates smooth muscle cell phenotype to a distinct inflammatory state relative to PDGF-DD via NF-κB-dependent mechanisms Physiological Genomics. 44: 417-429. PMID 22318995 DOI: 10.1152/Physiolgenomics.00160.2011  0.76
2012 Alexander MR, Moehle CW, Johnson JL, Yang Z, Lee JK, Jackson CL, Owens GK. Genetic inactivation of IL-1 signaling enhances atherosclerotic plaque instability and reduces outward vessel remodeling in advanced atherosclerosis in mice. The Journal of Clinical Investigation. 122: 70-9. PMID 22201681 DOI: 10.1172/Jci43713  0.48
2012 Alexander MR, Owens GK. Epigenetic control of smooth muscle cell differentiation and phenotypic switching in vascular development and disease. Annual Review of Physiology. 74: 13-40. PMID 22017177 DOI: 10.1146/Annurev-Physiol-012110-142315  0.6
2011 Moehle CW, Bhamidipati CM, Alexander MR, Mehta GS, Irvine JN, Salmon M, Upchurch GR, Kron IL, Owens GK, Ailawadi G. Bone marrow-derived MCP1 required for experimental aortic aneurysm formation and smooth muscle phenotypic modulation. The Journal of Thoracic and Cardiovascular Surgery. 142: 1567-74. PMID 21996300 DOI: 10.1016/J.Jtcvs.2011.07.053  0.6
2011 Gan Q, Thiébaud P, Thézé N, Jin L, Xu G, Grant P, Owens GK. WD repeat-containing protein 5, a ubiquitously expressed histone methyltransferase adaptor protein, regulates smooth muscle cell-selective gene activation through interaction with pituitary homeobox 2. The Journal of Biological Chemistry. 286: 21853-64. PMID 21531708 DOI: 10.1074/Jbc.M111.233098  0.76
2011 Hoofnagle MH, Neppl RL, Berzin EL, Teg Pipes GC, Olson EN, Wamhoff BW, Somlyo AV, Owens GK. Myocardin is differentially required for the development of smooth muscle cells and cardiomyocytes. American Journal of Physiology. Heart and Circulatory Physiology. 300: H1707-21. PMID 21357509 DOI: 10.1152/Ajpheart.01192.2010  0.48
2010 Dioufa N, Schally AV, Chatzistamou I, Moustou E, Block NL, Owens GK, Papavassiliou AG, Kiaris H. Acceleration of wound healing by growth hormone-releasing hormone and its agonists. Proceedings of the National Academy of Sciences of the United States of America. 107: 18611-5. PMID 20937882 DOI: 10.1073/pnas.1013942107  0.48
2010 Jin L, Gan Q, Zieba BJ, Goicoechea SM, Owens GK, Otey CA, Somlyo AV. The actin associated protein palladin is important for the early smooth muscle cell differentiation. Plos One. 5: e12823. PMID 20877641 DOI: 10.1371/Journal.Pone.0012823  0.48
2010 Yoshida T, Gan Q, Franke AS, Ho R, Zhang J, Chen YE, Hayashi M, Majesky MW, Somlyo AV, Owens GK. Smooth and cardiac muscle-selective knock-out of Kruppel-like factor 4 causes postnatal death and growth retardation. The Journal of Biological Chemistry. 285: 21175-84. PMID 20439457 DOI: 10.1074/Jbc.M110.112482  0.48
2009 Ailawadi G, Moehle CW, Pei H, Walton SP, Yang Z, Kron IL, Lau CL, Owens GK. Smooth muscle phenotypic modulation is an early event in aortic aneurysms. The Journal of Thoracic and Cardiovascular Surgery. 138: 1392-9. PMID 19931668 DOI: 10.1016/J.Jtcvs.2009.07.075  0.6
2009 Nickerson MM, Song J, Meisner JK, Bajikar S, Burke CW, Shuptrine CW, Owens GK, Skalak TC, Price RJ. Bone marrow-derived cell-specific chemokine (C-C motif) receptor-2 expression is required for arteriolar remodeling. Arteriosclerosis, Thrombosis, and Vascular Biology. 29: 1794-801. PMID 19734197 DOI: 10.1161/Atvbaha.109.194019  0.48
2009 Salmon M, Owens GK, Zehner ZE. Over-expression of the transcription factor, ZBP-89, leads to enhancement of the C2C12 myogenic program. Biochimica Et Biophysica Acta. 1793: 1144-55. PMID 19232372 DOI: 10.1016/J.Bbamcr.2009.01.019  0.76
2009 Deaton RA, Gan Q, Owens GK. Sp1-dependent activation of KLF4 is required for PDGF-BB-induced phenotypic modulation of smooth muscle. American Journal of Physiology. Heart and Circulatory Physiology. 296: H1027-37. PMID 19168719 DOI: 10.1152/Ajpheart.01230.2008  0.76
2009 Cherepanova OA, Pidkovka NA, Sarmento OF, Yoshida T, Gan Q, Adiguzel E, Bendeck MP, Berliner J, Leitinger N, Owens GK. Oxidized phospholipids induce type VIII collagen expression and vascular smooth muscle cell migration. Circulation Research. 104: 609-18. PMID 19168440 DOI: 10.1161/Circresaha.108.186064  0.76
2009 Sinha S, Hoofnagle MH, Owens GK. Derivation of contractile smooth muscle cells from embryonic stem cells. Methods in Molecular Biology (Clifton, N.J.). 482: 345-67. PMID 19089367 DOI: 10.1007/978-1-59745-060-7_22  0.84
2009 Thomas JA, Deaton RA, Hastings NE, Shang Y, Moehle CW, Eriksson U, Topouzis S, Wamhoff BR, Blackman BR, Owens GK. PDGF-DD, a novel mediator of smooth muscle cell phenotypic modulation, is upregulated in endothelial cells exposed to atherosclerosis-prone flow patterns. American Journal of Physiology. Heart and Circulatory Physiology. 296: H442-52. PMID 19028801 DOI: 10.1152/Ajpheart.00165.2008  0.76
2009 Jin L, Yoshida T, Ho R, Owens GK, Somlyo AV. The actin-associated protein Palladin is required for development of normal contractile properties of smooth muscle cells derived from embryoid bodies. The Journal of Biological Chemistry. 284: 2121-30. PMID 19015263 DOI: 10.1074/Jbc.M806095200  0.76
2009 Kawai-Kowase K, Ohshima T, Matsui H, Tanaka T, Shimizu T, Iso T, Arai M, Owens GK, Kurabayashi M. PIAS1 mediates TGFbeta-induced SM alpha-actin gene expression through inhibition of KLF4 function-expression by protein sumoylation. Arteriosclerosis, Thrombosis, and Vascular Biology. 29: 99-106. PMID 18927467 DOI: 10.1161/Atvbaha.108.172700  0.64
2008 Yoshida T, Gan Q, Owens GK. Kruppel-like factor 4, Elk-1, and histone deacetylases cooperatively suppress smooth muscle cell differentiation markers in response to oxidized phospholipids. American Journal of Physiology. Cell Physiology. 295: C1175-82. PMID 18768922 DOI: 10.1152/Ajpcell.00288.2008  0.76
2008 Wamhoff BR, Lynch KR, Macdonald TL, Owens GK. Sphingosine-1-phosphate receptor subtypes differentially regulate smooth muscle cell phenotype. Arteriosclerosis, Thrombosis, and Vascular Biology. 28: 1454-61. PMID 18535287 DOI: 10.1161/Atvbaha.107.159392  0.76
2008 Yoshida T, Kaestner KH, Owens GK. Conditional deletion of Krüppel-like factor 4 delays downregulation of smooth muscle cell differentiation markers but accelerates neointimal formation following vascular injury. Circulation Research. 102: 1548-57. PMID 18483411 DOI: 10.1161/Circresaha.108.176974  0.64
2008 Shang Y, Yoshida T, Amendt BA, Martin JF, Owens GK. Pitx2 is functionally important in the early stages of vascular smooth muscle cell differentiation. The Journal of Cell Biology. 181: 461-73. PMID 18458156 DOI: 10.1083/Jcb.200711145  0.76
2007 Gan Q, Yoshida T, Li J, Owens GK. Smooth muscle cells and myofibroblasts use distinct transcriptional mechanisms for smooth muscle alpha-actin expression. Circulation Research. 101: 883-92. PMID 17823374 DOI: 10.1161/Circresaha.107.154831  0.76
2007 Pidkovka NA, Cherepanova OA, Yoshida T, Alexander MR, Deaton RA, Thomas JA, Leitinger N, Owens GK. Oxidized phospholipids induce phenotypic switching of vascular smooth muscle cells in vivo and in vitro. Circulation Research. 101: 792-801. PMID 17704209 DOI: 10.1161/Circresaha.107.152736  0.76
2007 McDonald OG, Owens GK. Programming smooth muscle plasticity with chromatin dynamics. Circulation Research. 100: 1428-41. PMID 17525382 DOI: 10.1161/01.Res.0000266448.30370.A0  0.92
2007 Liao Y, Regan CP, Manabe I, Owens GK, Day KH, Damon DN, Duling BR. Smooth muscle-targeted knockout of connexin43 enhances neointimal formation in response to vascular injury. Arteriosclerosis, Thrombosis, and Vascular Biology. 27: 1037-42. PMID 17332489 DOI: 10.1161/Atvbaha.106.137182  0.76
2007 Lin CH, Platt MD, Ficarro SB, Hoofnagle MH, Shabanowitz J, Comai L, Hunt DF, Owens GK. Mass spectrometric identification of phosphorylation sites of rRNA transcription factor upstream binding factor. American Journal of Physiology. Cell Physiology. 292: C1617-24. PMID 17182730 DOI: 10.1152/Ajpcell.00176.2006  0.76
2007 Gan Q, Yoshida T, McDonald OG, Owens GK. Concise review: epigenetic mechanisms contribute to pluripotency and cell lineage determination of embryonic stem cells. Stem Cells (Dayton, Ohio). 25: 2-9. PMID 17023513 DOI: 10.1634/Stemcells.2006-0383  0.92
2007 Yoshida T, Gan Q, Shang Y, Owens GK. Platelet-derived growth factor-BB represses smooth muscle cell marker genes via changes in binding of MKL factors and histone deacetylases to their promoters. American Journal of Physiology. Cell Physiology. 292: C886-95. PMID 16987998 DOI: 10.1152/Ajpcell.00449.2006  0.76
2007 Kawai-Kowase K, Owens GK. Multiple repressor pathways contribute to phenotypic switching of vascular smooth muscle cells. American Journal of Physiology. Cell Physiology. 292: C59-69. PMID 16956962 DOI: 10.1152/Ajpcell.00394.2006  0.64
2006 Hoofnagle MH, Thomas JA, Wamhoff BR, Owens GK. Origin of neointimal smooth muscle: we've come full circle. Arteriosclerosis, Thrombosis, and Vascular Biology. 26: 2579-81. PMID 17110606 DOI: 10.1161/01.Atv.0000249623.79871.Bc  0.84
2006 Wamhoff BR, Bowles DK, Owens GK. Excitation-transcription coupling in arterial smooth muscle. Circulation Research. 98: 868-78. PMID 16614312 DOI: 10.1161/01.RES.0000216596.73005.3c  0.84
2006 Sinha S, Wamhoff BR, Hoofnagle MH, Thomas J, Neppl RL, Deering T, Helmke BP, Bowles DK, Somlyo AV, Owens GK. Assessment of contractility of purified smooth muscle cells derived from embryonic stem cells. Stem Cells (Dayton, Ohio). 24: 1678-88. PMID 16601077 DOI: 10.1634/Stemcells.2006-0002  0.76
2006 Davis CA, Haberland M, Arnold MA, Sutherland LB, McDonald OG, Richardson JA, Childs G, Harris S, Owens GK, Olson EN. PRISM/PRDM6, a transcriptional repressor that promotes the proliferative gene program in smooth muscle cells. Molecular and Cellular Biology. 26: 2626-36. PMID 16537907 DOI: 10.1128/Mcb.26.7.2626-2636.2006  0.76
2006 Khromov AS, Wang H, Choudhury N, McDuffie M, Herring BP, Nakamoto R, Owens GK, Somlyo AP, Somlyo AV. Smooth muscle of telokin-deficient mice exhibits increased sensitivity to Ca2+ and decreased cGMP-induced relaxation. Proceedings of the National Academy of Sciences of the United States of America. 103: 2440-5. PMID 16461919 DOI: 10.1073/Pnas.0508566103  0.76
2006 Gorenne I, Jin L, Yoshida T, Sanders JM, Sarembock IJ, Owens GK, Somlyo AP, Somlyo AV. LPP expression during in vitro smooth muscle differentiation and stent-induced vascular injury. Circulation Research. 98: 378-85. PMID 16397143 DOI: 10.1161/01.Res.0000202802.34727.Fd  0.76
2006 McDonald OG, Wamhoff BR, Hoofnagle MH, Owens GK. Control of SRF binding to CArG box chromatin regulates smooth muscle gene expression in vivo. The Journal of Clinical Investigation. 116: 36-48. PMID 16395403 DOI: 10.1172/Jci26505  0.92
2005 Pipes GC, Sinha S, Qi X, Zhu CH, Gallardo TD, Shelton J, Creemers EE, Sutherland L, Richardson JA, Garry DJ, Wright WE, Owens GK, Olson EN. Stem cells and their derivatives can bypass the requirement of myocardin for smooth muscle gene expression. Developmental Biology. 288: 502-13. PMID 16310178 DOI: 10.1016/J.Ydbio.2005.10.014  0.64
2005 O'Neill TJ, Wamhoff BR, Owens GK, Skalak TC. Mobilization of bone marrow-derived cells enhances the angiogenic response to hypoxia without transdifferentiation into endothelial cells. Circulation Research. 97: 1027-35. PMID 16210550 DOI: 10.1161/01.Res.0000189259.69645.25  0.84
2005 Kawai-Kowase K, Kumar MS, Hoofnagle MH, Yoshida T, Owens GK. PIAS1 activates the expression of smooth muscle cell differentiation marker genes by interacting with serum response factor and class I basic helix-loop-helix proteins. Molecular and Cellular Biology. 25: 8009-23. PMID 16135793 DOI: 10.1128/Mcb.25.18.8009-8023.2005  0.92
2005 Yoshida T, Owens GK. Molecular determinants of vascular smooth muscle cell diversity. Circulation Research. 96: 280-91. PMID 15718508 DOI: 10.1161/01.RES.0000155951.62152.2e  0.64
2005 Hendrix JA, Wamhoff BR, McDonald OG, Sinha S, Yoshida T, Owens GK. 5' CArG degeneracy in smooth muscle alpha-actin is required for injury-induced gene suppression in vivo. The Journal of Clinical Investigation. 115: 418-27. PMID 15690088 DOI: 10.1172/Jci22648  0.76
2005 Liu Y, Sinha S, McDonald OG, Shang Y, Hoofnagle MH, Owens GK. Kruppel-like factor 4 abrogates myocardin-induced activation of smooth muscle gene expression. The Journal of Biological Chemistry. 280: 9719-27. PMID 15623517 DOI: 10.1074/Jbc.M412862200  0.92
2005 Perlegas D, Xie H, Sinha S, Somlyo AV, Owens GK. ANG II type 2 receptor regulates smooth muscle growth and force generation in late fetal mouse development. American Journal of Physiology. Heart and Circulatory Physiology. 288: H96-102. PMID 15331365 DOI: 10.1152/Ajpheart.00620.2004  0.76
2004 Wamhoff BR, Hoofnagle MH, Burns A, Sinha S, McDonald OG, Owens GK. A G/C element mediates repression of the SM22alpha promoter within phenotypically modulated smooth muscle cells in experimental atherosclerosis. Circulation Research. 95: 981-8. PMID 15486317 DOI: 10.1161/01.Res.0000147961.09840.Fb  0.92
2004 Somlyo AV, Wang H, Choudhury N, Khromov AS, Majesky M, Owens GK, Somlyo AP. Myosin light chain kinase knockout Journal of Muscle Research and Cell Motility. 25: 241-242. PMID 15467390 DOI: 10.1023/B:Jure.0000038362.84697.C0  0.76
2004 Sinha S, Hoofnagle MH, Kingston PA, McCanna ME, Owens GK. Transforming growth factor-beta1 signaling contributes to development of smooth muscle cells from embryonic stem cells. American Journal of Physiology. Cell Physiology. 287: C1560-8. PMID 15306544 DOI: 10.1152/Ajpcell.00221.2004  0.76
2004 Owens GK, Kumar MS, Wamhoff BR. Molecular regulation of vascular smooth muscle cell differentiation in development and disease. Physiological Reviews. 84: 767-801. PMID 15269336 DOI: 10.1152/Physrev.00041.2003  0.92
2004 Wamhoff BR, Bowles DK, McDonald OG, Sinha S, Somlyo AP, Somlyo AV, Owens GK. L-type voltage-gated Ca2+ channels modulate expression of smooth muscle differentiation marker genes via a rho kinase/myocardin/SRF-dependent mechanism. Circulation Research. 95: 406-14. PMID 15256479 DOI: 10.1161/01.Res.0000138582.36921.9E  0.76
2004 Yoshida T, Kawai-Kowase K, Owens GK. Forced expression of myocardin is not sufficient for induction of smooth muscle differentiation in multipotential embryonic cells. Arteriosclerosis, Thrombosis, and Vascular Biology. 24: 1596-601. PMID 15231515 DOI: 10.1161/01.Atv.0000137190.63214.C5  0.64
2004 Hoofnagle MH, Wamhoff BR, Owens GK. Lost in transdifferentiation. The Journal of Clinical Investigation. 113: 1249-51. PMID 15124012 DOI: 10.1172/Jci21761  0.84
2004 Yoshida T, Hoofnagle MH, Owens GK. Myocardin and Prx1 contribute to angiotensin II-induced expression of smooth muscle alpha-actin. Circulation Research. 94: 1075-82. PMID 15016729 DOI: 10.1161/01.Res.0000125622.46280.95  0.84
2004 Dandré F, Owens GK. Platelet-derived growth factor-BB and Ets-1 transcription factor negatively regulate transcription of multiple smooth muscle cell differentiation marker genes. American Journal of Physiology. Heart and Circulatory Physiology. 286: H2042-51. PMID 14751865 DOI: 10.1152/Ajpheart.00625.2003  0.32
2003 Kumar MS, Owens GK. Combinatorial control of smooth muscle-specific gene expression. Arteriosclerosis, Thrombosis, and Vascular Biology. 23: 737-47. PMID 12740224 DOI: 10.1161/01.Atv.0000065197.07635.Ba  0.92
2003 Kumar MS, Hendrix JA, Johnson AD, Owens GK. Smooth muscle alpha-actin gene requires two E-boxes for proper expression in vivo and is a target of class I basic helix-loop-helix proteins. Circulation Research. 92: 840-7. PMID 12663487 DOI: 10.1161/01.Res.0000069031.55281.7C  0.76
2003 Yoshida T, Sinha S, Dandré F, Wamhoff BR, Hoofnagle MH, Kremer BE, Wang DZ, Olson EN, Owens GK. Myocardin is a key regulator of CArG-dependent transcription of multiple smooth muscle marker genes. Circulation Research. 92: 856-64. PMID 12663482 DOI: 10.1161/01.Res.0000068405.49081.09  0.84
2003 Du KL, Ip HS, Li J, Chen M, Dandre F, Yu W, Lu MM, Owens GK, Parmacek MS. Myocardin is a critical serum response factor cofactor in the transcriptional program regulating smooth muscle cell differentiation. Molecular and Cellular Biology. 23: 2425-37. PMID 12640126 DOI: 10.1128/Mcb.23.7.2425-2437.2003  0.36
2001 Taylor JM, Mack CP, Nolan K, Regan CP, Owens GK, Parsons JT. Selective expression of an endogenous inhibitor of FAK regulates proliferation and migration of vascular smooth muscle cells Molecular and Cellular Biology. 21: 1565-1572. PMID 11238893 DOI: 10.1128/Mcb.21.5.1565-1572.2001  0.76
2001 Mack CP, Somlyo AV, Hautmann M, Somlyo AP, Owens GK. Smooth muscle differentiation marker gene expression is regulated by Rhoa-mediated actin polymerization Journal of Biological Chemistry. 276: 341-347. PMID 11035001 DOI: 10.1074/Jbc.M005505200  0.76
2000 Regan CP, Adam PJ, Madsen CS, Owens GK. Molecular mechanisms of decreased smooth muscle differentiation marker expression after vascular injury. The Journal of Clinical Investigation. 106: 1139-47. PMID 11067866 DOI: 10.1172/Jci10522  0.76
2000 Adam PJ, Regan CP, Hautmann MB, Owens GK. Positive- and negative-acting Kruppel-like transcription factors bind a transforming growth factor beta control element required for expression of the smooth muscle cell differentiation marker SM22alpha in vivo. The Journal of Biological Chemistry. 275: 37798-806. PMID 10954723 DOI: 10.1074/Jbc.M006323200  0.76
2000 Mack CP, Thompson MM, Lawrenz-Smith S, Owens GK. Smooth muscle a-actin CArG elements coordinate formation of a smooth muscle cell-selective, serum response factor-containing activation complex Circulation Research. 86: 221-232. PMID 10666419 DOI: 10.1161/01.Res.86.2.221  0.76
2000 Wiegman PJ, Barry WL, McPherson JA, McNamara CA, Gimple LW, Sanders JM, Bishop GG, Powers ER, Ragosta M, Owens GK, Sarembock IJ. All-trans-retinoic acid limits restenosis after balloon angioplasty in the focally atherosclerotic rabbit : a favorable effect on vessel remodeling. Arteriosclerosis, Thrombosis, and Vascular Biology. 20: 89-95. PMID 10634804 DOI: 10.1161/01.Atv.20.1.89  0.76
1999 Bishop GG, Wiegman P, McNamara C, Din S, Sanders J, Hesselbacher S, Feldman M, McPherson JA, Humphries JE, Hammarskjold ML, Gimple LW, Ragosta M, Powers ER, Dickek D, Owens GK, et al. Local adenovirus-mediated delivery of hirudin in a rabbit arterial injury model. Journal of Vascular Research. 36: 343-52; discussion 4. PMID 10559674 DOI: 10.1159/000025672  0.76
1999 Jung F, Johnson AD, Kumar MS, Wei B, Hautmann M, Owens GK, McNamara C. Characterization of an E-box-dependent cis element in the smooth muscle alpha-actin promoter. Arteriosclerosis, Thrombosis, and Vascular Biology. 19: 2591-9. PMID 10559000 DOI: 10.1161/01.Atv.19.11.2591  0.92
1999 Hautmann MB, Adam PJ, Owens GK. Similarities and differences in smooth muscle alpha-actin induction by TGF-beta in smooth muscle versus non-smooth muscle cells. Arteriosclerosis, Thrombosis, and Vascular Biology. 19: 2049-58. PMID 10479645 DOI: 10.1161/01.Atv.19.9.2049  0.76
1999 Johnson AD, Owens GK. Differential activation of the SMαA promoter in smooth vs. skeletal muscle cells by bHLH factors American Journal of Physiology - Cell Physiology. 276. PMID 10362606 DOI: 10.1152/Ajpcell.1999.276.6.C1420  0.76
1998 Swartz EA, Johnson AD, Owens GK. Two MCAT elements of the SM α-actin promoter function differentially in SM vs. non-SM cells. American Journal of Physiology. Cell Physiology. 275: C608-C618. PMID 29585670 DOI: 10.1152/ajpcell.1998.275.2.C608  0.6
1998 Kihm AJ, Hershey JC, Haystead TA, Madsen CS, Owens GK. Phosphorylation of the rRNA transcription factor upstream binding factor promotes its association with TATA binding protein. Proceedings of the National Academy of Sciences of the United States of America. 95: 14816-20. PMID 9843972 DOI: 10.1073/Pnas.95.25.14816  0.76
1998 Thome LM, Gimple LW, Bachhuber BG, McNamara CA, Ragosta M, Gertz SD, Powers ER, Owens GK, Humphries JE, Sarembock IJ. Early plus delayed hirudin reduces restenosis in the atherosclerotic rabbit more than early administration alone: potential implications for dosing of antithrombin agents. Circulation. 98: 2301-6. PMID 9826318 DOI: 10.1161/01.Cir.98.21.2301  0.76
1997 Gertz SD, Barry WL, Gimple LW, Banai S, Perez LS, McNamara CA, Powers ER, Ragosta M, Owens GK, Roberts WC, Sarembock IJ. Predictors of luminal narrowing by neointima after angioplasty in atherosclerotic rabbits. Cardiovascular Research. 36: 396-407. PMID 9534861 DOI: 10.1016/S0008-6363(97)00168-5  0.76
1997 Hautmann MB, Thompson MM, Swartz EA, Olson EN, Owens GK. Angiotensin II-induced stimulation of smooth muscle alpha-actin expression by serum response factor and the homeodomain transcription factor MHox. Circulation Research. 81: 600-10. PMID 9314842 DOI: 10.1161/01.Res.81.4.600  0.32
1997 Vernon SM, Campos MJ, Haystead T, Thompson MM, DiCorleto PE, Owens GK. Endothelial cell-conditioned medium downregulates smooth muscle contractile protein expression American Journal of Physiology - Cell Physiology. 272. PMID 9124302 DOI: 10.1152/Ajpcell.1997.272.2.C582  0.76
1997 Bachhuber BG, Sarembock IJ, Gimple LW, Owens GK. α-Thrombin induces transforming growth factor-β1 mRNA and protein in cultured vascular smooth muscle cells via a proteolytically activated receptor Journal of Vascular Research. 34: 41-48. PMID 9075824 DOI: 10.1159/000159200  0.76
1996 Barry WL, Gimple LW, Humphries JE, Powers ER, McCoy KW, Sanders JM, Owens GK, Sarembock IJ. Arterial thrombin activity after angioplasty in an atherosclerotic rabbit model: time course and effect of hirudin. Circulation. 94: 88-93. PMID 8964123 DOI: 10.1161/01.Cir.94.1.88  0.76
1996 Hungerford JE, Owens GK, Argraves WS, Little CD. Development of the aortic vessel wall as defined by vascular smooth muscle and extracellular matrix markers. Developmental Biology. 178: 375-92. PMID 8812136 DOI: 10.1006/Dbio.1996.0225  0.76
1996 McNamara CA, Sarembock IJ, Bachhuber BG, Stouffer GA, Ragosta M, Barry W, Gimple LW, Powers ER, Owens GK. Thrombin and vascular smooth muscle cell proliferation: implications for atherosclerosis and restenosis. Seminars in Thrombosis and Hemostasis. 22: 139-44. PMID 8807710 DOI: 10.1055/S-2007-999001  0.76
1996 Ragosta M, Barry WL, Gimple LW, Gertz SD, McCoy KW, Stouffer GA, McNamara CA, Powers ER, Owens GK, Sarembock IJ. Effect of thrombin inhibition with desulfatohirudin on early kinetics of cellular proliferation after balloon angioplasty in atherosclerotic rabbits. Circulation. 93: 1194-200. PMID 8653841 DOI: 10.1161/01.Cir.93.6.1194  0.76
1995 Webb DJ, Hussaini IM, Weaver AM, Atkins TL, Chu CT, Pizzo SV, Owens GK, Gonias SL. Activated alpha 2-macroglobulin promotes mitogenesis in rat vascular smooth muscle cells by a mechanism that is independent of growth-factor-carrier activity. European Journal of Biochemistry / Febs. 234: 714-22. PMID 8575427 DOI: 10.1111/J.1432-1033.1995.714_A.X  0.76
1995 Weaver AM, Owens GK, Gonias SL. Native and activated forms of α2-macroglobulin increase expression of platelet-derived growth factor α-receptor in vascular smooth muscle cells: Evidence for autocrine transforming growth factor-β activity Journal of Biological Chemistry. 270: 30741-30748. PMID 8530514 DOI: 10.1074/Jbc.270.51.30741  0.76
1995 Bachhuber BG, Sarembock IJ, Gimple LW, McNamara CA, Owens GK. Thrombin-induced mitogenesis in cultured aortic smooth muscle cells requires prolonged thrombin exposure. The American Journal of Physiology. 268: C1141-7. PMID 7762606 DOI: 10.1152/Ajpcell.1995.268.5.C1141  0.76
1995 Blank RS, Swartz EA, Thompson MM, Olson EN, Owens GK. A retinoic acid-induced clonal cell line derived from multipotential P19 embryonal carcinoma cells expresses smooth muscle characteristics. Circulation Research. 76: 742-9. PMID 7728990 DOI: 10.1161/01.Res.76.5.742  0.32
1995 Lesh RE, Somlyo AP, Owens GK, Somlyo AV. Reversible permeabilization: A novel technique for the intracellular introduction of antisense oligodeoxynucleotides into intact smooth muscle Circulation Research. 77: 220-230. PMID 7614709 DOI: 10.1161/01.Res.77.2.220  0.76
1995 Hershey JC, Hautmann M, Thompson MM, Rothblum LI, Haystead TA, Owens GK. Angiotensin II-induced hypertrophy of rat vascular smooth muscle is associated with increased 18 S rRNA synthesis and phosphorylation of the rRNA transcription factor, upstream binding factor. The Journal of Biological Chemistry. 270: 25096-101. PMID 7559641 DOI: 10.1074/Jbc.270.42.25096  0.76
1995 McNamara CA, Sarembock IJ, Gimple LW, Fenton JW, Owens GK. Human thrombin receptor‐activating peptide‐induced proliferation of cultured vascular smooth muscle cells exhibits species specificity Drug Development Research. 35: 7-12. DOI: 10.1002/Ddr.430350103  0.76
1994 Price RJ, Owens GK, Skalak TC. Immunohistochemical identification of arteriolar development using markers of smooth muscle differentiation: Evidence that capillary arterialization proceeds from terminal arterioles Circulation Research. 75: 520-527. PMID 8062425 DOI: 10.1161/01.Res.75.3.520  0.76
1993 McNamara CA, Sarembock IJ, Gimple LW, Fenton JW, Coughlin SR, Owens GK. Thrombin stimulates proliferation of cultured rat aortic smooth muscle cells by a proteolytically activated receptor. The Journal of Clinical Investigation. 91: 94-8. PMID 8380817 DOI: 10.1172/Jci116206  0.76
1993 Stouffer GA, Sarembock IJ, McNamara CA, Gimple LW, Owens GK. Thrombin-induced mitogenesis of vascular SMC is partially mediated by autocrine production of PDGF-AA. The American Journal of Physiology. 265: C806-11. PMID 8214037 DOI: 10.1152/Ajpcell.1993.265.3.C806  0.76
1992 Holycross BJ, Blank RS, Thompson MM, Peach MJ, Owens GK. Platelet-derived growth factor-BB-induced suppression of smooth muscle cell differentiation Circulation Research. 71: 1525-1532. PMID 1423945 DOI: 10.1161/01.Res.71.6.1525  0.76
1991 Lehman RM, Owens GK, Kassell NF, Hongo K. Mechanism of enlargement of major cerebral collateral arteries in rabbits Stroke. 22: 499-504. PMID 2024279 DOI: 10.1161/01.Str.22.4.499  0.76
1991 Turla MB, Thompson MM, Corjay MH, Owens GK. Mechanisms of angiotensin II- and arginine vasopressin-induced increases in protein synthesis and content in cultured rat aortic smooth muscle cells. Evidence for selective increases in smooth muscle isoactin expression Circulation Research. 68: 288-299. PMID 1984869 DOI: 10.1161/01.Res.68.1.288  0.76
1989 White KP, Radke-Sharpe NF, Kaiser DL, Owens GK. A dynamic model of angiotensin II infusion experiments. Journal of Biomedical Engineering. 11: 63-71. PMID 2648070 DOI: 10.1016/0141-5425(89)90168-4  0.76
1988 Blank RS, Thompson MM, Owens GK. Cell cycle versus density dependence of smooth muscle alpha actin expression in cultured rat aortic smooth muscle cells Journal of Cell Biology. 107: 299-306. PMID 3392101 DOI: 10.1083/Jcb.107.1.299  0.76
1986 Owens GK, Loeb A, Gordon D, Thompson MM. Expression of smooth muscle-specific α-isoactin in cultured vascular smooth muscle cells: relationship between growth and cytodifferentiation Journal of Cell Biology. 102: 343-352. PMID 3944187 DOI: 10.1083/jcb.102.2.343  0.76
1983 Barrett TB, Sampson P, Owens GK, Schwartz SM, Benditt EP. Polyploid nuclei in human artery wall smooth muscle cells Proceedings of the National Academy of Sciences of the United States of America. 80: 882-885. PMID 6572376 DOI: 10.1073/Pnas.80.3.882  0.76
1981 Owens GK, Hollis TM. Local aortic histamine metabolism and albumin accumulation. Differences between blue and white areas Arteriosclerosis. 1: 265-272. PMID 7295198 DOI: 10.1161/01.Atv.1.4.265  0.76
1979 Owens GK, Hollis TM. Relationship between inhibition of aortic histamine formation, aortic albumin permeability and atherosclerosis Atherosclerosis. 34: 365-373. PMID 518743 DOI: 10.1016/0021-9150(79)90061-3  0.76
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