James R. Lokensgard - Publications

Affiliations: 
University of Minnesota, Twin Cities, Minneapolis, MN 
Area:
Molecular Biology, Cell Biology, Immunology

64 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Chauhan P, Hu S, Prasad S, Sheng WS, Lokensgard JR. Programmed death ligand-1 induction restrains the cytotoxic T lymphocyte response against microglia. Glia. PMID 33128485 DOI: 10.1002/glia.23932  0.56
2020 Fernández-Alarcón C, Meyer LE, McVoy MA, Lokensgard JR, Hu S, Benneyworth MA, Anderholm KM, Janus BC, Schleiss MR. Impairment in neurocognitive function following experimental neonatal guinea pig cytomegalovirus infection. Pediatric Research. PMID 32555536 DOI: 10.1038/s41390-020-1010-7  0.56
2019 Prasad S, Hu S, Sheng WS, Chauhan P, Lokensgard JR. Recall Responses from Brain-Resident Memory CD8 T Cells (bT) Induce Reactive Gliosis. Iscience. 20: 512-526. PMID 31655062 DOI: 10.1016/j.isci.2019.10.005  0.56
2019 Sheng WS, Chauhan P, Hu S, Prasad S, Lokensgard JR. Antiallodynic Effects of Cannabinoid Receptor 2 (CBR) Agonists on Retrovirus Infection-Induced Neuropathic Pain. Pain Research & Management. 2019: 1260353. PMID 31354896 DOI: 10.1155/2019/1260353  0.56
2018 Prasad S, Hu S, Sheng WS, Chauhan P, Lokensgard JR. Reactive glia promote development of CD103CD69CD8T-cells through programmed cell death-ligand 1 (PD-L1). Immunity, Inflammation and Disease. PMID 29602245 DOI: 10.1002/iid3.221  0.56
2018 Chauhan P, Sheng WS, Hu S, Prasad S, Lokensgard JR. Nitrosative damage during retrovirus infection-induced neuropathic pain. Journal of Neuroinflammation. 15: 66. PMID 29506535 DOI: 10.1186/s12974-018-1107-7  0.56
2017 Prasad S, Hu S, Sheng WS, Chauhan P, Singh A, Lokensgard JR. The PD-1: PD-L1 pathway promotes development of brain-resident memory T cells following acute viral encephalitis. Journal of Neuroinflammation. 14: 82. PMID 28407741 DOI: 10.1186/s12974-017-0860-3  0.56
2017 Chauhan P, Hu S, Sheng WS, Prasad S, Lokensgard JR. Modulation of Microglial Cell Fcγ Receptor Expression Following Viral Brain Infection. Scientific Reports. 7: 41889. PMID 28165503 DOI: 10.1038/srep41889  0.56
2016 Lokensgard JR, Mutnal MB, Prasad S, Sheng W, Hu S. Glial cell activation, recruitment, and survival of B-lineage cells following MCMV brain infection. Journal of Neuroinflammation. 13: 114. PMID 27207308 DOI: 10.1186/s12974-016-0582-y  0.56
2015 Prasad S, Hu S, Sheng WS, Singh A, Lokensgard JR. Tregs Modulate Lymphocyte Proliferation, Activation, and Resident-Memory T-Cell Accumulation within the Brain during MCMV Infection. Plos One. 10: e0145457. PMID 26720146 DOI: 10.1371/journal.pone.0145457  0.56
2015 Lokensgard JR, Schachtele SJ, Mutnal MB, Sheng WS, Prasad S, Hu S. Chronic reactive gliosis following regulatory T cell depletion during acute MCMV encephalitis. Glia. PMID 26041050 DOI: 10.1002/glia.22868  0.56
2014 Mutnal MB, Hu S, Schachtele SJ, Lokensgard JR. Infiltrating regulatory B cells control neuroinflammation following viral brain infection. Journal of Immunology (Baltimore, Md. : 1950). 193: 6070-80. PMID 25385825 DOI: 10.4049/jimmunol.1400654  0.56
2014 Hu S, Rotschafer JH, Lokensgard JR, Cheeran MC. Activated CD8+ T lymphocytes inhibit neural stem/progenitor cell proliferation: role of interferon-gamma. Plos One. 9: e105219. PMID 25133679 DOI: 10.1371/journal.pone.0105219  0.56
2014 Schachtele SJ, Hu S, Sheng WS, Mutnal MB, Lokensgard JR. Glial cells suppress postencephalitic CD8+ T lymphocytes through PD-L1. Glia. 62: 1582-94. PMID 24890099 DOI: 10.1002/glia.22701  0.56
2013 Mutnal MB, Schachtele SJ, Hu S, Lokensgard JR. T-cell reconstitution during murine acquired immunodeficiency syndrome (MAIDS) produces neuroinflammation and mortality in animals harboring opportunistic viral brain infection. Journal of Neuroinflammation. 10: 98. PMID 23902750 DOI: 10.1186/1742-2094-10-98  0.56
2013 McGregor A, Choi KY, Schachtele S, Lokensgard J. Human Herpesviruses and Animal Models Animal Models For the Study of Human Disease. 905-925. DOI: 10.1016/B978-0-12-415894-8.00037-3  0.56
2012 Schachtele SJ, Hu S, Lokensgard JR. Modulation of experimental herpes encephalitis-associated neurotoxicity through sulforaphane treatment. Plos One. 7: e36216. PMID 22558388 DOI: 10.1371/journal.pone.0036216  0.56
2012 Mutnal MB, Hu S, Lokensgard JR. Persistent humoral immune responses in the CNS limit recovery of reactivated murine cytomegalovirus. Plos One. 7: e33143. PMID 22412996 DOI: 10.1371/journal.pone.0033143  0.56
2011 Hu S, Sheng WS, Schachtele SJ, Lokensgard JR. Reactive oxygen species drive herpes simplex virus (HSV)-1-induced proinflammatory cytokine production by murine microglia. Journal of Neuroinflammation. 8: 123. PMID 21943001 DOI: 10.1186/1742-2094-8-123  0.56
2011 Mutnal MB, Hu S, Little MR, Lokensgard JR. Memory T cells persisting in the brain following MCMV infection induce long-term microglial activation via interferon-γ. Journal of Neurovirology. 17: 424-37. PMID 21800103 DOI: 10.1007/s13365-011-0042-5  0.56
2011 Schachtele SJ, Mutnal MB, Schleiss MR, Lokensgard JR. Cytomegalovirus-induced sensorineural hearing loss with persistent cochlear inflammation in neonatal mice. Journal of Neurovirology. 17: 201-11. PMID 21416394 DOI: 10.1007/s13365-011-0024-7  0.56
2011 Mutnal MB, Cheeran MC, Hu S, Lokensgard JR. Murine cytomegalovirus infection of neural stem cells alters neurogenesis in the developing brain. Plos One. 6: e16211. PMID 21249143 DOI: 10.1371/journal.pone.0016211  0.56
2010 Sheng WS, Hu S, Nettles AR, Lokensgard JR, Vercellotti GM, Rock RB. Hemin inhibits NO production by IL-1β-stimulated human astrocytes through induction of heme oxygenase-1 and reduction of p38 MAPK activation. Journal of Neuroinflammation. 7: 51. PMID 20822529 DOI: 10.1186/1742-2094-7-51  0.56
2010 Mutnal MB, Cheeran MC, Hu S, Little MR, Lokensgard JR. Excess neutrophil infiltration during cytomegalovirus brain infection of interleukin-10-deficient mice. Journal of Neuroimmunology. 227: 101-10. PMID 20655600 DOI: 10.1016/j.jneuroim.2010.06.020  0.56
2010 Schachtele SJ, Hu S, Little MR, Lokensgard JR. Herpes simplex virus induces neural oxidative damage via microglial cell Toll-like receptor-2. Journal of Neuroinflammation. 7: 35. PMID 20584314 DOI: 10.1186/1742-2094-7-35  0.56
2010 El Ghazi I, Sheng WS, Hu S, Reilly BG, Lokensgard JR, Rock RB, Peterson PK, Wilcox GL, Armitage IM. Changes in the NMR metabolic profile of human microglial cells exposed to lipopolysaccharide or morphine. Journal of Neuroimmune Pharmacology : the Official Journal of the Society On Neuroimmune Pharmacology. 5: 574-81. PMID 20333557 DOI: 10.1007/s11481-010-9197-8  0.56
2010 Armien AG, Hu S, Little MR, Robinson N, Lokensgard JR, Low WC, Cheeran MC. Chronic cortical and subcortical pathology with associated neurological deficits ensuing experimental herpes encephalitis. Brain Pathology (Zurich, Switzerland). 20: 738-50. PMID 20002440 DOI: 10.1111/j.1750-3639.2009.00354.x  0.56
2009 Hu S, Sheng WS, Lokensgard JR, Peterson PK, Rock RB. Preferential sensitivity of human dopaminergic neurons to gp120-induced oxidative damage Journal of Neurovirology. 15: 401-410. PMID 20175694 DOI: 10.3109/13550280903296346  0.56
2009 Cheeran MC, Mutnal MB, Hu S, Armien A, Lokensgard JR. Reduced lymphocyte infiltration during cytomegalovirus brain infection of interleukin-10-deficient mice. Journal of Neurovirology. 15: 334-42. PMID 19626525 DOI: 10.1080/13550280903062797  0.56
2008 Marques CP, Cheeran MC, Palmquist JM, Hu S, Urban SL, Lokensgard JR. Prolonged microglial cell activation and lymphocyte infiltration following experimental herpes encephalitis. Journal of Immunology (Baltimore, Md. : 1950). 181: 6417-26. PMID 18941232  0.56
2008 Cheeran MC, Jiang Z, Hu S, Ni HT, Palmquist JM, Lokensgard JR. Cytomegalovirus infection and interferon-gamma modulate major histocompatibility complex class I expression on neural stem cells. Journal of Neurovirology. 14: 437-47. PMID 18937121 DOI: 10.1080/13550280802356845  0.56
2008 Aravalli RN, Hu S, Woods JP, Lokensgard JR. Histoplasma capsulatum yeast phase-specific protein Yps3p induces Toll-like receptor 2 signaling. Journal of Neuroinflammation. 5: 30. PMID 18606009 DOI: 10.1186/1742-2094-5-30  0.56
2008 Marques CP, Cheeran MC, Palmquist JM, Hu S, Lokensgard JR. Microglia are the major cellular source of inducible nitric oxide synthase during experimental herpes encephalitis. Journal of Neurovirology. 14: 229-38. PMID 18569457 DOI: 10.1080/13550280802093927  0.56
2008 Aravalli RN, Hu S, Lokensgard JR. Inhibition of toll-like receptor signaling in primary murine microglia. Journal of Neuroimmune Pharmacology : the Official Journal of the Society On Neuroimmune Pharmacology. 3: 5-11. PMID 18066668 DOI: 10.1007/s11481-007-9097-8  0.56
2007 Cheeran MC, Hu S, Palmquist JM, Bakken T, Gekker G, Lokensgard JR. Dysregulated interferon-gamma responses during lethal cytomegalovirus brain infection of IL-10-deficient mice. Virus Research. 130: 96-102. PMID 17624463 DOI: 10.1016/j.virusres.2007.05.022  0.56
2007 Sheng WS, Hu S, Herr G, Ni HT, Rock RB, Gekker G, Lokensgard JR, Peterson PK. Human neural precursor cells express functional κ-opioid receptors Journal of Pharmacology and Experimental Therapeutics. 322: 957-963. PMID 17538007 DOI: 10.1124/jpet.107.121988  0.56
2007 Aravalli RN, Hu S, Lokensgard JR. Toll-like receptor 2 signaling is a mediator of apoptosis in herpes simplex virus-infected microglia. Journal of Neuroinflammation. 4: 11. PMID 17470292 DOI: 10.1186/1742-2094-4-11  0.56
2006 Aravalli RN, Hu S, Rowen TN, Gekker G, Lokensgard JR. Differential apoptotic signaling in primary glial cells infected with herpes simplex virus 1. Journal of Neurovirology. 12: 501-10. PMID 17162665 DOI: 10.1080/13550280601064921  0.56
2006 Hu S, Cheeran MC, Sheng WS, Ni HT, Lokensgard JR, Peterson PK. Cocaine alters proliferation, migration, and differentiation of human fetal brain-derived neural precursor cells. The Journal of Pharmacology and Experimental Therapeutics. 318: 1280-6. PMID 16766721 DOI: 10.1124/jpet.106.103853  0.56
2006 Gekker G, Hu S, Sheng WS, Rock RB, Lokensgard JR, Peterson PK. Cocaine-induced HIV-1 expression in microglia involves sigma-1 receptors and transforming growth factor-β1 International Immunopharmacology. 6: 1029-1033. PMID 16644490 DOI: 10.1016/j.intimp.2005.12.005  0.56
2006 Marques CP, Hu S, Sheng W, Lokensgard JR. Microglial cells initiate vigorous yet non-protective immune responses during HSV-1 brain infection. Virus Research. 121: 1-10. PMID 16621100 DOI: 10.1016/j.virusres.2006.03.009  0.56
2005 Cheeran MC, Hu S, Sheng WS, Rashid A, Peterson PK, Lokensgard JR. Differential responses of human brain cells to West Nile virus infection. Journal of Neurovirology. 11: 512-24. PMID 16338745 DOI: 10.1080/13550280500384982  0.56
2005 Sheng WS, Hu S, Ni HT, Rowen TN, Lokensgard JR, Peterson PK. TNF-alpha-induced chemokine production and apoptosis in human neural precursor cells. Journal of Leukocyte Biology. 78: 1233-41. PMID 16314440 DOI: 10.1189/jlb.0405221  0.56
2005 Cheeran MC, Hu S, Ni HT, Sheng W, Palmquist JM, Peterson PK, Lokensgard JR. Neural precursor cell susceptibility to human cytomegalovirus diverges along glial or neuronal differentiation pathways. Journal of Neuroscience Research. 82: 839-50. PMID 16273540 DOI: 10.1002/jnr.20682  0.56
2005 Aravalli RN, Hu S, Rowen TN, Palmquist JM, Lokensgard JR. Cutting edge: TLR2-mediated proinflammatory cytokine and chemokine production by microglial cells in response to herpes simplex virus. Journal of Immunology (Baltimore, Md. : 1950). 175: 4189-93. PMID 16177057  0.56
2005 Gekker G, Hu S, Spivak M, Lokensgard JR, Peterson PK. Anti-HIV-1 activity of propolis in CD4(+) lymphocyte and microglial cell cultures. Journal of Ethnopharmacology. 102: 158-63. PMID 16046088 DOI: 10.1016/j.jep.2005.05.045  0.56
2005 Cheeran MC, Gekker G, Hu S, Palmquist JM, Lokensgard JR. T cell-mediated restriction of intracerebral murine cytomegalovirus infection displays dependence upon perforin but not interferon-gamma. Journal of Neurovirology. 11: 274-80. PMID 16036807 DOI: 10.1080/13550280590952808  0.56
2005 Hu S, Sheng WS, Lokensgard JR, Peterson PK. Morphine potentiates HIV-1 gp120-induced neuronal apoptosis. The Journal of Infectious Diseases. 191: 886-9. PMID 15717263 DOI: 10.1086/427830  0.56
2005 Sheng WS, Hu S, Min X, Cabral GA, Lokensgard JR, Peterson PK. Synthetic cannabinoid WIN55,212-2 inhibits generation of inflammatory mediators by IL-1beta-stimulated human astrocytes. Glia. 49: 211-9. PMID 15390091 DOI: 10.1002/glia.20108  0.56
2004 Rock RB, Gekker G, Hu S, Sheng WS, Cheeran M, Lokensgard JR, Peterson PK. Role of microglia in central nervous system infections Clinical Microbiology Reviews. 17: 942-964. PMID 15489356 DOI: 10.1128/CMR.17.4.942-964.2004  0.56
2004 Ni HT, Hu S, Sheng WS, Olson JM, Cheeran MC, Chan AS, Lokensgard JR, Peterson PK. High-level expression of functional chemokine receptor CXCR4 on human neural precursor cells. Brain Research. Developmental Brain Research. 152: 159-69. PMID 15351504 DOI: 10.1016/j.devbrainres.2004.06.015  0.56
2004 Marques CP, Hu S, Sheng W, Cheeran MC, Cox D, Lokensgard JR. Interleukin-10 attenuates production of HSV-induced inflammatory mediators by human microglia. Glia. 47: 358-66. PMID 15293233 DOI: 10.1002/glia.20045  0.56
2004 Cheeran MC, Gekker G, Hu S, Min X, Cox D, Lokensgard JR. Intracerebral infection with murine cytomegalovirus induces CXCL10 and is restricted by adoptive transfer of splenocytes. Journal of Neurovirology. 10: 152-62. PMID 15204920 DOI: 10.1080/13550280490441130  0.56
2004 Gekker G, Hu S, Wentland MP, Bidlack JM, Lokensgard JR, Peterson PK. κ-Opioid Receptor Ligands Inhibit Cocaine-Induced HIV-1 Expression in Microglial Cells Journal of Pharmacology and Experimental Therapeutics. 309: 600-606. PMID 14757849 DOI: 10.1124/jpet.103.060160  0.56
2003 Cheeran MC, Hu S, Sheng WS, Peterson PK, Lokensgard JR. CXCL10 production from cytomegalovirus-stimulated microglia is regulated by both human and viral interleukin-10. Journal of Virology. 77: 4502-15. PMID 12663757  0.56
2003 Sheng WS, Hu S, Lokensgard JR, Peterson PK. U50,488 inhibits HIV-1 Tat-induced monocyte chemoattractant protein-1 (CCL2) production by human astrocytes. Biochemical Pharmacology. 65: 9-14. PMID 12473373  0.56
2002 Lokensgard JR, Cheeran MC, Hu S, Gekker G, Peterson PK. Glial cell responses to herpesvirus infections: role in defense and immunopathogenesis. The Journal of Infectious Diseases. 186: S171-9. PMID 12424694 DOI: 10.1086/344272  0.56
2002 Hu S, Sheng WS, Lokensgard JR, Peterson PK. Morphine induces apoptosis of human microglia and neurons. Neuropharmacology. 42: 829-36. PMID 12015209  0.56
2001 Peterson PK, Gekker G, Hu S, Portoghese PS, Sheng WS, Lokensgard JR. Targeting the brain's immune system: a psychopharmacological approach to central nervous system infections. Advances in Experimental Medicine and Biology. 493: 1-6. PMID 11727754 DOI: 10.1007/0-306-47611-8_1  0.56
2001 Lokensgard JR, Hu S, Hegg CC, Thayer SA, Gekker G, Peterson PK. Diazepam inhibits HIV-1 Tat-induced migration of human microglia. Journal of Neurovirology. 7: 481-6. PMID 11582521 DOI: 10.1080/135502801753170345  0.56
2001 Peterson PK, Gekker G, Lokensgard JR, Bidlack JM, Chang AC, Fang X, Portoghese PS. Kappa-opioid receptor agonist suppression of HIV-1 expression in CD4+ lymphocytes. Biochemical Pharmacology. 61: 1145-51. PMID 11301048 DOI: 10.1016/S0006-2952(01)00574-3  0.56
1999 Peterson PK, Gekker G, Hu S, Lokensgard J, Portoghese PS, Chao CC. Endomorphin-1 potentiates HIV-1 expression in human brain cell cultures: implication of an atypical mu-opioid receptor. Neuropharmacology. 38: 273-8. PMID 10218868 DOI: 10.1016/S0028-3908(98)00167-1  0.56
1991 Lokensgard JR, Thawley DG, Molitor TW. Enzymatic amplification of latent pseudorabies virus nucleic acid sequences Journal of Virological Methods. 34: 45-55. PMID 1659580 DOI: 10.1016/0166-0934(91)90120-O  0.56
1990 Lokensgard JR, Thawley DG, Molitor TW. Pseudorabies virus latency: restricted transcription Archives of Virology. 110: 129-136. PMID 2155596 DOI: 10.1007/BF01310709  0.56
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