Mark A. Magnuson - Publications

Vanderbilt University, Nashville, TN 
Cell Biology, Molecular Biology, Genetics

189 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Osipovich AB, Zhou FY, Chong JJ, Trinh LT, Cottam MA, Shrestha S, Cartailler JP, Magnuson MA. Deletion of Ascl1 in pancreatic β-cells improves insulin secretion, promotes parasympathetic innervation, and attenuates dedifferentiation during metabolic stress. Molecular Metabolism. 101811. PMID 37769990 DOI: 10.1016/j.molmet.2023.101811  0.33
2023 Cha J, Tong X, Walker EM, Dahan T, Cochrane VA, Ashe S, Russell R, Osipovich AB, Mawla AM, Guo M, Liu JH, Loyd ZA, Huising MO, Magnuson MA, Hebrok M, et al. Species-specific roles for the MAFA and MAFB transcription factors in regulating islet β cell identity. Jci Insight. 8. PMID 37606041 DOI: 10.1172/jci.insight.166386  0.379
2023 Keller MP, Hawes EM, Schueler KL, Stapleton DS, Mitok KA, Simonett SP, Oeser JK, Sampson LL, Attie AD, Magnuson MA, O'Brien RM. An Enhancer Within Abcb11 Regulates G6pc2 in C57BL/6 Mouse Pancreatic Islets. Diabetes. PMID 37552875 DOI: 10.2337/db23-0215  0.387
2023 Abarinov V, Levine JA, Churchill AJ, Hopwood B, Deiter CS, Guney MA, Wells KL, Schrunk JM, Guo Y, Hammelman J, Gifford DK, Magnuson MA, Wichterle H, Sussel L. Major β cell-specific functions of NKX2.2 are mediated via the NK2-specific domain. Genes & Development. PMID 37364986 DOI: 10.1101/gad.350569.123  0.361
2023 Osipovich AB, Dudek KD, Trinh LT, Kim LH, Shrestha S, Cartailler JP, Magnuson MA. ZFP92, a KRAB domain zinc finger protein enriched in pancreatic islets, binds to B1/Alu SINE transposable elements and regulates retroelements and genes. Plos Genetics. 19: e1010729. PMID 37155670 DOI: 10.1371/journal.pgen.1010729  0.335
2023 Trinh LT, Osipovich AB, Liu B, Shrestha S, Cartailler JP, Wright CVE, Magnuson MA. Single-cell RNA sequencing of Sox17-expressing lineages reveals distinct gene regulatory networks and dynamic developmental trajectories. Stem Cells (Dayton, Ohio). PMID 37085274 DOI: 10.1093/stmcls/sxad030  0.314
2023 Ho KH, Jayathilake A, Mahircan Y, Nour A, Osipovich AB, Magnuson MA, Gu G, Kaverina I. CAMSAP2 localizes to the Golgi in islet β-cells and facilitates Golgi-ER trafficking. Iscience. 26: 105938. PMID 36718359 DOI: 10.1016/j.isci.2023.105938  0.312
2021 Dudek KD, Osipovich AB, Cartailler JP, Gu G, Magnuson MA. Insm1, Neurod1, and Pax6 promote murine pancreatic endocrine cell development through overlapping yet distinct RNA transcription and splicing programs. G3 (Bethesda, Md.). PMID 34534285 DOI: 10.1093/g3journal/jkab303  0.328
2021 Sanavia T, Huang C, Manduchi E, Xu Y, Dadi PK, Potter LA, Jacobson DA, Di Camillo B, Magnuson MA, Stoeckert CJ, Gu G. Temporal Transcriptome Analysis Reveals Dynamic Gene Expression Patterns Driving β-Cell Maturation. Frontiers in Cell and Developmental Biology. 9: 648791. PMID 34017831 DOI: 10.3389/fcell.2021.648791  0.382
2021 Osipovich AB, Dudek KD, Greenfest-Allen E, Cartailler JP, Manduchi E, Potter Case L, Choi E, Chapman AG, Clayton HW, Gu G, Stoeckert CJ, Magnuson MA. A developmental lineage-based gene co-expression network for mouse pancreatic β-cells reveals a role for in pancreas development. Development (Cambridge, England). PMID 33653874 DOI: 10.1242/dev.196964  0.396
2020 Ho KH, Yang X, Osipovich AB, Cabrera O, Hayashi ML, Magnuson MA, Gu G, Kaverina I. Glucose Regulates Microtubule Disassembly and the Dose of Insulin Secretion Via Tau Phosphorylation. Diabetes. PMID 32540877 DOI: 10.2337/Db19-1186  0.37
2020 Osipovich AB, Stancill JS, Cartailler JP, Dudek KD, Magnuson MA. Excitotoxicity and Overnutrition Additively Impair Metabolic Function and Identity of Pancreatic β-cells. Diabetes. PMID 32332159 DOI: 10.2337/Db19-1145  0.766
2019 Katholnig K, Schütz B, Fritsch SD, Schörghofer D, Linke M, Sukhbaatar N, Matschinger JM, Unterleuthner D, Hirtl M, Lang M, Herac M, Spittler A, Bergthaler A, Schabbauer G, Bergmann M, ... ... Magnuson MA, et al. Inactivation of mTORC2 in macrophages is a signature of colorectal cancer that promotes tumorigenesis. Jci Insight. 4. PMID 31619583 DOI: 10.1172/Jci.Insight.124164  0.308
2019 Spaeth JM, Liu JH, Peters D, Guo M, Osipovich AB, Mohammadi F, Roy N, Bhushan A, Magnuson MA, Hebrok M, Wright CVE, Stein R. The Pdx1 Bound Swi/Snf Chromatin Remodeling Complex Regulates Pancreatic Progenitor Cell Proliferation and Mature Islet β Cell Function. Diabetes. PMID 31201281 DOI: 10.2337/Db19-0349  0.495
2019 Wen HJ, Gao S, Wang Y, Ray M, Magnuson MA, Wright CVE, Di Magliano MP, Frankel TL, Crawford HC. Myeloid cell-derived HB-EGF Drives Tissue Recovery After Pancreatitis. Cellular and Molecular Gastroenterology and Hepatology. PMID 31125624 DOI: 10.1016/J.Jcmgh.2019.05.006  0.333
2018 Stancill JS, Osipovich AB, Cartailler JP, Magnuson MA. Transgene-associated hGH expression in pancreatic β-cells impairs identification of sex-based gene expression differences. American Journal of Physiology. Endocrinology and Metabolism. PMID 30532991 DOI: 10.1152/Ajpendo.00229.2018  0.775
2018 Cigliola V, Ghila L, Thorel F, van Gurp L, Baronnier D, Oropeza D, Gupta S, Miyatsuka T, Kaneto H, Magnuson MA, Osipovich AB, Sander M, Wright CEV, Thomas MK, Furuyama K, et al. Pancreatic islet-autonomous insulin and smoothened-mediated signalling modulate identity changes of glucagon α-cells. Nature Cell Biology. 20: 1267-1277. PMID 30361701 DOI: 10.1038/S41556-018-0216-Y  0.439
2018 Bankaitis ED, Bechard ME, Gu G, Magnuson MA, Wright CVE. ROCK-nmMyoII, Notch, and gene-dosage link epithelial morphogenesis with cell fate in the pancreatic endocrine-progenitor niche. Development (Cambridge, England). PMID 30126902 DOI: 10.1242/Dev.162115  0.423
2018 Huang C, Walker EM, Dadi PK, Hu R, Xu Y, Zhang W, Sanavia T, Mun J, Liu J, Nair GG, Tan HYA, Wang S, Magnuson MA, Stoeckert CJ, Hebrok M, et al. Synaptotagmin 4 Regulates Pancreatic β Cell Maturation by Modulating the Ca Sensitivity of Insulin Secretion Vesicles. Developmental Cell. PMID 29656931 DOI: 10.1016/J.Devcel.2018.03.013  0.435
2018 Potts A, Uchida A, Deja S, Berglund ED, Kucejova B, Duarte JAG, Fu X, Browning JD, Magnuson MA, Burgess SC. Cytosolic Phosphoenolpyruvate Carboxykinase as a Cataplerotic Pathway in the Small Intestine. American Journal of Physiology. Gastrointestinal and Liver Physiology. PMID 29631378 DOI: 10.1152/Ajpgi.00039.2018  0.321
2018 Osipovich AB, Magnuson MA. Alpha to Beta Cell Reprogramming: Stepping toward a New Treatment for Diabetes. Cell Stem Cell. 22: 12-13. PMID 29304337 DOI: 10.1016/J.Stem.2017.12.012  0.402
2017 Bechard ME, Bankaitis ED, Ustione A, Piston DW, Magnuson MA, Wright CVE. FUCCI tracking shows cell-cycle-dependent Neurog3 variation in pancreatic progenitors. Genesis (New York, N.Y. : 2000). PMID 28772022 DOI: 10.1002/Dvg.23050  0.389
2017 Spaeth JM, Gupte M, Perelis M, Yang YP, Cyphert H, Guo S, Liu JH, Guo M, Bass J, Magnuson MA, Wright C, Stein R. Defining a Novel Role for the PDX1 Transcription Factor in Islet β Cell Maturation and Proliferation During Weaning. Diabetes. PMID 28705881 DOI: 10.2337/Db16-1516  0.475
2017 Stancill JS, Cartailler JP, Clayton HW, O'Connor JT, Dickerson MT, Dadi PK, Osipovich AB, Jacobson DA, Magnuson MA. Chronic β-Cell Depolarization Impairs β-Cell Identity by Disrupting a Network of Ca(2+)-Regulated Genes. Diabetes. PMID 28550109 DOI: 10.2337/Db16-1355  0.765
2017 Tassone B, Saoncella S, Neri F, Ala U, Brusa D, Magnuson MA, Provero P, Oliviero S, Riganti C, Calautti E. Rictor/mTORC2 deficiency enhances keratinocyte stress tolerance via mitohormesis. Cell Death and Differentiation. PMID 28211872 DOI: 10.1038/Cdd.2017.8  0.354
2017 Sánchez-Arévalo Lobo VJ, Fernández LC, Carrillo-de-Santa-Pau E, Richart L, Cobo I, Cendrowski J, Moreno U, Del Pozo N, Megías D, Bréant B, Wright CV, Magnuson M, Real FX. c-Myc downregulation is required for preacinar to acinar maturation and pancreatic homeostasis. Gut. PMID 28159836 DOI: 10.1136/Gutjnl-2016-312306  0.313
2016 Yang YP, Magnuson MA, Stein R, Wright CV. The mammal-specific Pdx1 Area II enhancer has multiple essential functions in early endocrine-cell specification and postnatal β-cell maturation. Development (Cambridge, England). PMID 27993987 DOI: 10.1242/Dev.143123  0.481
2016 Osipovich AB, Gangula R, Vianna PG, Magnuson MA. Setd5 is essential for mammalian development and co-transcriptional regulation of histone acetylation. Development (Cambridge, England). PMID 27864380 DOI: 10.1242/Dev.141465  0.351
2016 Clayton HW, Osipovich AB, Stancill JS, Schneider JD, Vianna PG, Shanks CM, Yuan W, Gu G, Manduchi E, Stoeckert CJ, Magnuson MA. Pancreatic Inflammation Redirects Acinar to β Cell Reprogramming. Cell Reports. 17: 2028-2041. PMID 27851966 DOI: 10.1016/J.Celrep.2016.10.068  0.776
2016 Hoang CQ, Hale MA, Azevedo-Pouly A, Elsässer HP, Deering TG, Willet SG, Pan FC, Magnuson MA, Wright CV, Swift GH, MacDonald RJ. Transcriptional Maintenance of Pancreatic Acinar Identity, Differentiation and Homeostasis by PTF1A. Molecular and Cellular Biology. PMID 27697859 DOI: 10.1128/Mcb.00358-16  0.459
2016 Bechard ME, Bankaitis ED, Hipkens SB, Ustione A, Piston DW, Yang YP, Magnuson MA, Wright CV. Precommitment low-level Neurog3 expression defines a long-lived mitotic endocrine-biased progenitor pool that drives production of endocrine-committed cells. Genes & Development. PMID 27585590 DOI: 10.1101/Gad.284729.116  0.425
2016 Helman A, Klochendler A, Azazmeh N, Gabai Y, Horwitz E, Anzi S, Swisa A, Condiotti R, Granit RZ, Nevo Y, Fixler Y, Shreibman D, Zamir A, Tornovsky-Babeay S, Dai C, ... ... Magnuson MA, et al. p16(Ink4a)-induced senescence of pancreatic beta cells enhances insulin secretion. Nature Medicine. PMID 26950362 DOI: 10.1038/Nm.4054  0.461
2016 Marshall CB, Mays DJ, Beeler JS, Rosenbluth JM, Boyd KL, Santos Guasch GL, Shaver TM, Tang LJ, Liu Q, Shyr Y, Venters BJ, Magnuson MA, Pietenpol JA. p73 Is Required for Multiciliogenesis and Regulates the Foxj1-Associated Gene Network. Cell Reports. PMID 26947080 DOI: 10.1016/J.Celrep.2016.02.035  0.34
2015 Lorenzen SM, Duggan A, Osipovich AB, Magnuson MA, García-Añoveros J. Insm1 promotes neurogenic proliferation in delaminated otic progenitors. Mechanisms of Development. PMID 26545349 DOI: 10.1016/J.Mod.2015.11.001  0.361
2015 Shih HP, Seymour PA, Patel NA, Xie R, Wang A, Liu PP, Yeo GW, Magnuson MA, Sander M. A Gene Regulatory Network Cooperatively Controlled by Pdx1 and Sox9 Governs Lineage Allocation of Foregut Progenitor Cells. Cell Reports. PMID 26440894 DOI: 10.1016/J.Celrep.2015.08.082  0.403
2015 Golson ML, Dunn JC, Maulis MF, Dadi PK, Osipovich AB, Magnuson MA, Jacobson DA, Gannon M. Activation of FoxM1 Revitalizes the Replicative Potential of Aged β-Cells in Male Mice and Enhances Insulin Secretion. Diabetes. 64: 3829-38. PMID 26251404 DOI: 10.2337/Db15-0465  0.465
2014 Brouwers B, de Faudeur G, Osipovich AB, Goyvaerts L, Lemaire K, Boesmans L, Cauwelier EJ, Granvik M, Pruniau VP, Van Lommel L, Van Schoors J, Stancill JS, Smolders I, Goffin V, Binart N, ... ... Magnuson MA, et al. Impaired islet function in commonly used transgenic mouse lines due to human growth hormone minigene expression. Cell Metabolism. 20: 979-90. PMID 25470546 DOI: 10.1016/J.Cmet.2014.11.004  0.788
2014 Willet SG, Hale MA, Grapin-Botton A, Magnuson MA, MacDonald RJ, Wright CV. Dominant and context-specific control of endodermal organ allocation by Ptf1a. Development (Cambridge, England). 141: 4385-94. PMID 25371369 DOI: 10.1242/Dev.114165  0.408
2014 Osipovich AB, Long Q, Manduchi E, Gangula R, Hipkens SB, Schneider J, Okubo T, Stoeckert CJ, Takada S, Magnuson MA. Insm1 promotes endocrine cell differentiation by modulating the expression of a network of genes that includes Neurog3 and Ripply3. Development (Cambridge, England). 141: 2939-49. PMID 25053427 DOI: 10.1242/Dev.104810  0.489
2014 Seto Y, Nakatani T, Masuyama N, Taya S, Kumai M, Minaki Y, Hamaguchi A, Inoue YU, Inoue T, Miyashita S, Fujiyama T, Yamada M, Chapman H, Campbell K, Magnuson MA, et al. Temporal identity transition from Purkinje cell progenitors to GABAergic interneuron progenitors in the cerebellum. Nature Communications. 5: 3337. PMID 24535035 DOI: 10.1038/Ncomms4337  0.319
2014 Hang Y, Yamamoto T, Benninger RK, Brissova M, Guo M, Bush W, Piston DW, Powers AC, Magnuson M, Thurmond DC, Stein R. The MafA transcription factor becomes essential to islet β-cells soon after birth. Diabetes. 63: 1994-2005. PMID 24520122 DOI: 10.2337/Db13-1001  0.499
2014 Worchel HN, Magnuson MA. Cytokine-driven beta-cell production in vivo. Nature Biotechnology. 32: 63-4. PMID 24406931 DOI: 10.1038/Nbt.2788  0.368
2014 Tornovsky-Babeay S, Dadon D, Ziv O, Tzipilevich E, Kadosh T, Schyr-Ben Haroush R, Hija A, Stolovich-Rain M, Furth-Lavi J, Granot Z, Porat S, Philipson LH, Herold KC, Bhatti TR, Stanley C, ... ... Magnuson MA, et al. Type 2 diabetes and congenital hyperinsulinism cause DNA double-strand breaks and p53 activity in β cells. Cell Metabolism. 19: 109-21. PMID 24332968 DOI: 10.1016/J.Cmet.2013.11.007  0.339
2013 Balderes DA, Magnuson MA, Sussel L. Nkx2.2:Cre knock-in mouse line: a novel tool for pancreas- and CNS-specific gene deletion. Genesis (New York, N.Y. : 2000). 51: 844-51. PMID 23996959 DOI: 10.1002/Dvg.22715  0.454
2013 Magnuson MA, Osipovich AB. Pancreas-specific Cre driver lines and considerations for their prudent use. Cell Metabolism. 18: 9-20. PMID 23823474 DOI: 10.1016/J.Cmet.2013.06.011  0.377
2013 Kartikasari AE, Zhou JX, Kanji MS, Chan DN, Sinha A, Grapin-Botton A, Magnuson MA, Lowry WE, Bhushan A. The histone demethylase Jmjd3 sequentially associates with the transcription factors Tbx3 and Eomes to drive endoderm differentiation. The Embo Journal. 32: 1393-408. PMID 23584530 DOI: 10.1038/Emboj.2013.78  0.385
2013 Hickey RD, Galivo F, Schug J, Brehm MA, Haft A, Wang Y, Benedetti E, Gu G, Magnuson MA, Shultz LD, Lagasse E, Greiner DL, Kaestner KH, Grompe M. Generation of islet-like cells from mouse gall bladder by direct ex vivo reprogramming. Stem Cell Research. 11: 503-15. PMID 23562832 DOI: 10.1016/J.Scr.2013.02.005  0.492
2013 Schaffer AE, Taylor BL, Benthuysen JR, Liu J, Thorel F, Yuan W, Jiao Y, Kaestner KH, Herrera PL, Magnuson MA, May CL, Sander M. Nkx6.1 controls a gene regulatory network required for establishing and maintaining pancreatic Beta cell identity. Plos Genetics. 9: e1003274. PMID 23382704 DOI: 10.1371/Journal.Pgen.1003274  0.456
2013 Pan FC, Bankaitis ED, Boyer D, Xu X, Van de Casteele M, Magnuson MA, Heimberg H, Wright CV. Spatiotemporal patterns of multipotentiality in Ptf1a-expressing cells during pancreas organogenesis and injury-induced facultative restoration. Development (Cambridge, England). 140: 751-64. PMID 23325761 DOI: 10.1242/Dev.090159  0.47
2012 Arnes L, Hill JT, Gross S, Magnuson MA, Sussel L. Ghrelin expression in the mouse pancreas defines a unique multipotent progenitor population. Plos One. 7: e52026. PMID 23251675 DOI: 10.1371/Journal.Pone.0052026  0.478
2012 Serup P, Gustavsen C, Klein T, Potter LA, Lin R, Mullapudi N, Wandzioch E, Hines A, Davis A, Bruun C, Engberg N, Petersen DR, Peterslund JM, Macdonald RJ, Grapin-Botton A, ... Magnuson MA, et al. Partial promoter substitutions generating transcriptional sentinels of diverse signaling pathways in embryonic stem cells and mice. Disease Models & Mechanisms. 5: 956-66. PMID 22888097 DOI: 10.1242/Dmm.009696  0.357
2012 Choi E, Kraus MR, Lemaire LA, Yoshimoto M, Vemula S, Potter LA, Manduchi E, Stoeckert CJ, Grapin-Botton A, Magnuson MA. Dual lineage-specific expression of Sox17 during mouse embryogenesis. Stem Cells (Dayton, Ohio). 30: 2297-308. PMID 22865702 DOI: 10.1002/Stem.1192  0.437
2012 Sato Y, Hatta M, Karim MF, Sawa T, Wei FY, Sato S, Magnuson MA, Gonzalez FJ, Tomizawa K, Akaike T, Yoshizawa T, Yamagata K. Anks4b, a novel target of HNF4α protein, interacts with GRP78 protein and regulates endoplasmic reticulum stress-induced apoptosis in pancreatic β-cells. The Journal of Biological Chemistry. 287: 23236-45. PMID 22589549 DOI: 10.1074/Jbc.M112.368779  0.42
2012 Arnes L, Leclerc K, Friel JM, Hipkens SB, Magnuson MA, Sussel L. Generation of Nkx2.2:lacZ mice using recombination-mediated cassette exchange technology. Genesis (New York, N.Y. : 2000). 50: 612-24. PMID 22539496 DOI: 10.1002/Dvg.22037  0.469
2012 Horn S, Kobberup S, Jørgensen MC, Kalisz M, Klein T, Kageyama R, Gegg M, Lickert H, Lindner J, Magnuson MA, Kong YY, Serup P, Ahnfelt-Rønne J, Jensen JN. Mind bomb 1 is required for pancreatic β-cell formation. Proceedings of the National Academy of Sciences of the United States of America. 109: 7356-61. PMID 22529374 DOI: 10.1073/Pnas.1203605109  0.458
2012 Kopinke D, Brailsford M, Pan FC, Magnuson MA, Wright CV, Murtaugh LC. Ongoing Notch signaling maintains phenotypic fidelity in the adult exocrine pancreas. Developmental Biology. 362: 57-64. PMID 22146645 DOI: 10.1016/J.Ydbio.2011.11.010  0.465
2012 Petersen DR, Gustavsen C, Lindskog SR, Magnuson MA, Zaret KS, Serup P. Engineering artificial signaling centers to polarize embryoid body differentiation. Stem Cells and Development. 21: 647-53. PMID 21958075 DOI: 10.1089/Scd.2011.0344  0.329
2012 Potter LA, Choi E, Hipkens SB, Wright CV, Magnuson MA. A recombinase-mediated cassette exchange-derived cyan fluorescent protein reporter allele for Pdx1. Genesis (New York, N.Y. : 2000). 50: 384-92. PMID 21913313 DOI: 10.1002/Dvg.20804  0.378
2011 Papizan JB, Singer RA, Tschen SI, Dhawan S, Friel JM, Hipkens SB, Magnuson MA, Bhushan A, Sussel L. Nkx2.2 repressor complex regulates islet β-cell specification and prevents β-to-α-cell reprogramming. Genes & Development. 25: 2291-305. PMID 22056672 DOI: 10.1101/Gad.173039.111  0.414
2011 Plank JL, Frist AY, LeGrone AW, Magnuson MA, Labosky PA. Loss of Foxd3 results in decreased β-cell proliferation and glucose intolerance during pregnancy. Endocrinology. 152: 4589-600. PMID 21952247 DOI: 10.1210/En.2010-1462  0.439
2011 Watanabe H, Yang T, Stroud DM, Lowe JS, Harris L, Atack TC, Wang DW, Hipkens SB, Leake B, Hall L, Kupershmidt S, Chopra N, Magnuson MA, Tanabe N, Knollmann BC, et al. Striking In vivo phenotype of a disease-associated human SCN5A mutation producing minimal changes in vitro. Circulation. 124: 1001-11. PMID 21824921 DOI: 10.1161/Circulationaha.110.987248  0.361
2011 Atack TC, Stroud DM, Watanabe H, Yang T, Hall L, Hipkens SB, Lowe JS, Leake B, Magnuson MA, Yang P, Roden DM. Informatic and functional approaches to identifying a regulatory region for the cardiac sodium channel. Circulation Research. 109: 38-46. PMID 21566215 DOI: 10.1161/Circresaha.110.235630  0.326
2011 Salpeter SJ, Klochendler A, Weinberg-Corem N, Porat S, Granot Z, Shapiro AM, Magnuson MA, Eden A, Grimsby J, Glaser B, Dor Y. Glucose regulates cyclin D2 expression in quiescent and replicating pancreatic β-cells through glycolysis and calcium channels. Endocrinology. 152: 2589-98. PMID 21521747 DOI: 10.1210/En.2010-1372  0.386
2011 Porat S, Weinberg-Corem N, Tornovsky-Babaey S, Schyr-Ben-Haroush R, Hija A, Stolovich-Rain M, Dadon D, Granot Z, Ben-Hur V, White P, Girard CA, Karni R, Kaestner KH, Ashcroft FM, Magnuson MA, et al. Control of pancreatic β cell regeneration by glucose metabolism. Cell Metabolism. 13: 440-9. PMID 21459328 DOI: 10.1016/J.Cmet.2011.02.012  0.443
2011 Chen SX, Osipovich AB, Ustione A, Potter LA, Hipkens S, Gangula R, Yuan W, Piston DW, Magnuson MA. Quantification of factors influencing fluorescent protein expression using RMCE to generate an allelic series in the ROSA26 locus in mice. Disease Models & Mechanisms. 4: 537-47. PMID 21324933 DOI: 10.1242/Dmm.006569  0.414
2011 Gu Y, Lindner J, Kumar A, Yuan W, Magnuson MA. Rictor/mTORC2 is essential for maintaining a balance between beta-cell proliferation and cell size. Diabetes. 60: 827-37. PMID 21266327 DOI: 10.2337/Db10-1194  0.374
2011 Kumar A, Keller SR, Kim JK, Magnuson MA, Harris TE. Response to Comment on: Kumar et al. Fat cell-specific ablation of rictor in mice impairs insulin-regulated fat cell and whole-body glucose and lipid metabolism. Diabetes 2010;59:1397-1406 Diabetes. 60: e15. DOI: 10.2337/Db11-0135  0.409
2010 Artner I, Hang Y, Mazur M, Yamamoto T, Guo M, Lindner J, Magnuson MA, Stein R. MafA and MafB regulate genes critical to beta-cells in a unique temporal manner. Diabetes. 59: 2530-9. PMID 20627934 DOI: 10.2337/Db10-0190  0.464
2010 Lee K, Gudapati P, Dragovic S, Spencer C, Joyce S, Killeen N, Magnuson MA, Boothby M. Mammalian target of rapamycin protein complex 2 regulates differentiation of Th1 and Th2 cell subsets via distinct signaling pathways. Immunity. 32: 743-53. PMID 20620941 DOI: 10.1016/J.Immuni.2010.06.002  0.358
2010 Boulbes D, Chen CH, Shaikenov T, Agarwal NK, Peterson TR, Addona TA, Keshishian H, Carr SA, Magnuson MA, Sabatini DM, Sarbassov dos D. Rictor phosphorylation on the Thr-1135 site does not require mammalian target of rapamycin complex 2. Molecular Cancer Research : McR. 8: 896-906. PMID 20501647 DOI: 10.1158/1541-7786.Mcr-09-0409  0.302
2010 Masui T, Swift GH, Deering T, Shen C, Coats WS, Long Q, Elsässer HP, Magnuson MA, MacDonald RJ. Replacement of Rbpj with Rbpjl in the PTF1 complex controls the final maturation of pancreatic acinar cells. Gastroenterology. 139: 270-80. PMID 20398665 DOI: 10.1053/J.Gastro.2010.04.003  0.386
2010 Kumar A, Lawrence JC, Jung DY, Ko HJ, Keller SR, Kim JK, Magnuson MA, Harris TE. Fat cell-specific ablation of rictor in mice impairs insulin-regulated fat cell and whole-body glucose and lipid metabolism. Diabetes. 59: 1397-406. PMID 20332342 DOI: 10.2337/Db09-1061  0.419
2010 Jiang M, Fernandez S, Jerome WG, He Y, Yu X, Cai H, Boone B, Yi Y, Magnuson MA, Roy-Burman P, Matusik RJ, Shappell SB, Hayward SW. Disruption of PPARγ signaling results in mouse prostatic intraepithelial neoplasia involving active autophagy Cell Death and Differentiation. 17: 469-481. PMID 19834493 DOI: 10.1038/Cdd.2009.148  0.36
2009 Zhang H, Ables ET, Pope CF, Washington MK, Hipkens S, Means AL, Path G, Seufert J, Costa RH, Leiter AB, Magnuson MA, Gannon M. Multiple, temporal-specific roles for HNF6 in pancreatic endocrine and ductal differentiation. Mechanisms of Development. 126: 958-73. PMID 19766716 DOI: 10.1016/J.Mod.2009.09.006  0.469
2009 Huppert SS, Magnuson MA. New complexity in differentiating stem cells toward hepatic and pancreatic fates. Science Signaling. 2: pe50. PMID 19671927 DOI: 10.1126/Scisignal.283Pe50  0.432
2009 Berglund ED, Lee-Young RS, Lustig DG, Lynes SE, Donahue EP, Camacho RC, Meredith ME, Magnuson MA, Charron MJ, Wasserman DH. Hepatic energy state is regulated by glucagon receptor signaling in mice. The Journal of Clinical Investigation. 119: 2412-22. PMID 19662685 DOI: 10.1172/Jci38650  0.33
2009 Wang S, Jensen JN, Seymour PA, Hsu W, Dor Y, Sander M, Magnuson MA, Serup P, Gu G. Sustained Neurog3 expression in hormone-expressing islet cells is required for endocrine maturation and function. Proceedings of the National Academy of Sciences of the United States of America. 106: 9715-20. PMID 19487660 DOI: 10.1073/Pnas.0904247106  0.497
2008 Zelent B, Odili S, Buettger C, Shiota C, Grimsby J, Taub R, Magnuson MA, Vanderkooi JM, Matschinsky FM. Sugar binding to recombinant wild-type and mutant glucokinase monitored by kinetic measurement and tryptophan fluorescence. The Biochemical Journal. 413: 269-80. PMID 18370929 DOI: 10.1042/Bj20071718  0.302
2008 Burlison JS, Long Q, Fujitani Y, Wright CV, Magnuson MA. Pdx-1 and Ptf1a concurrently determine fate specification of pancreatic multipotent progenitor cells. Developmental Biology. 316: 74-86. PMID 18294628 DOI: 10.1016/J.Ydbio.2008.01.011  0.774
2008 Shiota M, Magnuson MA. Hepatic glucose sensing: does flux matter? The Journal of Clinical Investigation. 118: 841-4. PMID 18292804 DOI: 10.1172/Jci35137  0.358
2008 Hori K, Cholewa-Waclaw J, Nakada Y, Glasgow SM, Masui T, Henke RM, Wildner H, Martarelli B, Beres TM, Epstein JA, Magnuson MA, Macdonald RJ, Birchmeier C, Johnson JE. A nonclassical bHLH Rbpj transcription factor complex is required for specification of GABAergic neurons independent of Notch signaling. Genes & Development. 22: 166-78. PMID 18198335 DOI: 10.1101/Gad.1628008  0.321
2008 Gannon M, Ables ET, Crawford L, Lowe D, Offield MF, Magnuson MA, Wright CV. pdx-1 function is specifically required in embryonic beta cells to generate appropriate numbers of endocrine cell types and maintain glucose homeostasis. Developmental Biology. 314: 406-17. PMID 18155690 DOI: 10.1016/J.Ydbio.2007.10.038  0.482
2008 Kumar A, Harris TE, Keller SR, Choi KM, Magnuson MA, Lawrence JC. Muscle-specific deletion of rictor impairs insulin-stimulated glucose transport and enhances Basal glycogen synthase activity. Molecular and Cellular Biology. 28: 61-70. PMID 17967879 DOI: 10.1128/Mcb.01405-07  0.341
2007 Masui T, Long Q, Beres TM, Magnuson MA, MacDonald RJ. Early pancreatic development requires the vertebrate Suppressor of Hairless (RBPJ) in the PTF1 bHLH complex. Genes & Development. 21: 2629-43. PMID 17938243 DOI: 10.1101/Gad.1575207  0.372
2007 Wang S, Zhang J, Zhao A, Hipkens S, Magnuson MA, Gu G. Loss of Myt1 function partially compromises endocrine islet cell differentiation and pancreatic physiological function in the mouse. Mechanisms of Development. 124: 898-910. PMID 17928203 DOI: 10.1016/J.Mod.2007.08.004  0.509
2007 Magnuson MA, Burlison JS. Caveats and considerations for performing pancreas-specific gene manipulations in the mouse. Diabetes, Obesity & Metabolism. 9: 5-13. PMID 17919173 DOI: 10.1111/J.1463-1326.2007.00771.X  0.772
2007 Niswender KD, Magnuson MA. Obesity and the beta cell: lessons from leptin. The Journal of Clinical Investigation. 117: 2753-6. PMID 17909621 DOI: 10.1172/Jci33528  0.404
2007 Burgess SC, He T, Yan Z, Lindner J, Sherry AD, Malloy CR, Browning JD, Magnuson MA. Cytosolic phosphoenolpyruvate carboxykinase does not solely control the rate of hepatic gluconeogenesis in the intact mouse liver. Cell Metabolism. 5: 313-20. PMID 17403375 DOI: 10.1016/J.Cmet.2007.03.004  0.342
2007 Pino MF, Kim KA, Shelton KD, Lindner J, Odili S, Li C, Collins HW, Shiota M, Matschinsky FM, Magnuson MA. Glucokinase thermolability and hepatic regulatory protein binding are essential factors for predicting the blood glucose phenotype of missense mutations. The Journal of Biological Chemistry. 282: 13906-16. PMID 17353190 DOI: 10.1074/Jbc.M610094200  0.36
2007 Yoshida K, Murao K, Imachi H, Cao WM, Yu X, Li J, Ahmed RA, Kitanaka N, Wong NC, Unterman TG, Magnuson MA, Ishida T. Pancreatic glucokinase is activated by insulin-like growth factor-I. Endocrinology. 148: 2904-13. PMID 17317782 DOI: 10.1210/En.2006-1149  0.44
2007 Oottamasathien S, Wang Y, Williams K, Franco OE, Wills ML, Thomas JC, Saba K, Sharif-Afshar AR, Makari JH, Bhowmick NA, DeMarco RT, Hipkens S, Magnuson M, Brock JW, Hayward SW, et al. Directed differentiation of embryonic stem cells into bladder tissue. Developmental Biology. 304: 556-66. PMID 17289017 DOI: 10.1016/J.Ydbio.2007.01.010  0.382
2006 Liu K, Hipkens S, Yang T, Abraham R, Zhang W, Chopra N, Knollmann B, Magnuson MA, Roden DM. Recombinase-mediated cassette exchange to rapidly and efficiently generate mice with human cardiac sodium channels. Genesis (New York, N.Y. : 2000). 44: 556-64. PMID 17083109 DOI: 10.1002/Dvg.20247  0.332
2006 Fujitani Y, Fujitani S, Luo H, Qiu F, Burlison J, Long Q, Kawaguchi Y, Edlund H, MacDonald RJ, Furukawa T, Fujikado T, Magnuson MA, Xiang M, Wright CV. Ptf1a determines horizontal and amacrine cell fates during mouse retinal development. Development (Cambridge, England). 133: 4439-50. PMID 17075007 DOI: 10.1242/Dev.02598  0.754
2006 Shiota C, Woo JT, Lindner J, Shelton KD, Magnuson MA. Multiallelic disruption of the rictor gene in mice reveals that mTOR complex 2 is essential for fetal growth and viability. Developmental Cell. 11: 583-9. PMID 16962829 DOI: 10.1016/J.Devcel.2006.08.013  0.357
2006 Doliba NM, Qin W, Vatamaniuk MZ, Buettger CW, Collins HW, Magnuson MA, Kaestner KH, Wilson DF, Carr RD, Matschinsky FM. Cholinergic regulation of fuel-induced hormone secretion and respiration of SUR1-/- mouse islets. American Journal of Physiology. Endocrinology and Metabolism. 291: E525-35. PMID 16638820 DOI: 10.1152/Ajpendo.00579.2005  0.374
2006 Stiles BL, Kuralwalla-Martinez C, Guo W, Gregorian C, Wang Y, Tian J, Magnuson MA, Wu H. Selective deletion of Pten in pancreatic beta cells leads to increased islet mass and resistance to STZ-induced diabetes. Molecular and Cellular Biology. 26: 2772-81. PMID 16537919 DOI: 10.1128/Mcb.26.7.2772-2781.2006  0.436
2006 Fujitani Y, Fujitani S, Boyer DF, Gannon M, Kawaguchi Y, Ray M, Shiota M, Stein RW, Magnuson MA, Wright CV. Targeted deletion of a cis-regulatory region reveals differential gene dosage requirements for Pdx1 in foregut organ differentiation and pancreas formation. Genes & Development. 20: 253-66. PMID 16418487 DOI: 10.1101/Gad.1360106  0.355
2006 Matschinsky FM, Magnuson MA, Zelent D, Jetton TL, Doliba N, Han Y, Taub R, Grimsby J. The network of glucokinase-expressing cells in glucose homeostasis and the potential of glucokinase activators for diabetes therapy. Diabetes. 55: 1-12. PMID 16380470 DOI: 10.2337/Diabetes.55.01.06.Db05-0926  0.391
2006 Miura A, Yamagata K, Kakei M, Hatakeyama H, Takahashi N, Fukui K, Nammo T, Yoneda K, Inoue Y, Sladek FM, Magnuson MA, Kasai H, Miyagawa J, Gonzalez FJ, Shimomura I. Hepatocyte nuclear factor-4alpha is essential for glucose-stimulated insulin secretion by pancreatic beta-cells. The Journal of Biological Chemistry. 281: 5246-57. PMID 16377800 DOI: 10.1074/Jbc.M507496200  0.451
2006 Lee JY, Ristow M, Lin X, White MF, Magnuson MA, Hennighausen L. RIP-Cre revisited, evidence for impairments of pancreatic beta-cell function. The Journal of Biological Chemistry. 281: 2649-53. PMID 16326700 DOI: 10.1074/Jbc.M512373200  0.479
2005 Thierbach R, Schulz TJ, Isken F, Voigt A, Mietzner B, Drewes G, von Kleist-Retzow JC, Wiesner RJ, Magnuson MA, Puccio H, Pfeiffer AF, Steinberg P, Ristow M. Targeted disruption of hepatic frataxin expression causes impaired mitochondrial function, decreased life span and tumor growth in mice. Human Molecular Genetics. 14: 3857-64. PMID 16278235 DOI: 10.1093/Hmg/Ddi410  0.305
2005 Park SY, Wang X, Chen Z, Powers AC, Magnuson MA, Head WS, Piston DW, Bell GI. Optical imaging of pancreatic beta cells in living mice expressing a mouse insulin I promoter-firefly luciferase transgene. Genesis (New York, N.Y. : 2000). 43: 80-6. PMID 16108006 DOI: 10.1002/Gene.20157  0.457
2005 Guan Y, Hao C, Cha DR, Rao R, Lu W, Kohan DE, Magnuson MA, Redha R, Zhang Y, Breyer MD. Thiazolidinediones expand body fluid volume through PPARgamma stimulation of ENaC-mediated renal salt absorption. Nature Medicine. 11: 861-6. PMID 16007095 DOI: 10.1038/Nm1278  0.326
2005 Roccisana J, Reddy V, Vasavada RC, Gonzalez-Pertusa JA, Magnuson MA, Garcia-Ocaña A. Targeted inactivation of hepatocyte growth factor receptor c-met in beta-cells leads to defective insulin secretion and GLUT-2 downregulation without alteration of beta-cell mass. Diabetes. 54: 2090-102. PMID 15983210 DOI: 10.2337/Diabetes.54.7.2090  0.457
2005 Babaev VR, Yancey PG, Ryzhov SV, Kon V, Breyer MD, Magnuson MA, Fazio S, Linton MF. Conditional knockout of macrophage PPARgamma increases atherosclerosis in C57BL/6 and low-density lipoprotein receptor-deficient mice. Arteriosclerosis, Thrombosis, and Vascular Biology. 25: 1647-53. PMID 15947238 DOI: 10.1161/01.Atv.0000173413.31789.1A  0.337
2005 Shiota C, Rocheleau JV, Shiota M, Piston DW, Magnuson MA. Impaired glucagon secretory responses in mice lacking the type 1 sulfonylurea receptor. American Journal of Physiology. Endocrinology and Metabolism. 289: E570-7. PMID 15941784 DOI: 10.1152/Ajpendo.00102.2005  0.381
2005 Gunawardana SC, Hara M, Bell GI, Head WS, Magnuson MA, Piston DW. Imaging Beta cell development in real-time using pancreatic explants from mice with green fluorescent protein-labeled pancreatic Beta cells. In Vitro Cellular & Developmental Biology. Animal. 41: 7-11. PMID 15926862 DOI: 10.1290/0412080.1  0.409
2005 Schonhoff S, Baggio L, Ratineau C, Ray SK, Lindner J, Magnuson MA, Drucker DJ, Leiter AB. Energy homeostasis and gastrointestinal endocrine differentiation do not require the anorectic hormone peptide YY. Molecular and Cellular Biology. 25: 4189-99. PMID 15870288 DOI: 10.1128/Mcb.25.10.4189-4199.2005  0.311
2005 Jones JR, Barrick C, Kim KA, Lindner J, Blondeau B, Fujimoto Y, Shiota M, Kesterson RA, Kahn BB, Magnuson MA. Deletion of PPARgamma in adipose tissues of mice protects against high fat diet-induced obesity and insulin resistance. Proceedings of the National Academy of Sciences of the United States of America. 102: 6207-12. PMID 15833818 DOI: 10.1073/Pnas.0306743102  0.367
2005 Wang CZ, Wang Y, Di A, Magnuson MA, Ye H, Roe MW, Nelson DJ, Bell GI, Philipson LH. 5-amino-imidazole carboxamide riboside acutely potentiates glucose-stimulated insulin secretion from mouse pancreatic islets by KATP channel-dependent and -independent pathways. Biochemical and Biophysical Research Communications. 330: 1073-9. PMID 15823553 DOI: 10.1016/J.Bbrc.2005.03.093  0.377
2005 Romero-Gallo J, Sozmen EG, Chytil A, Russell WE, Whitehead R, Parks WT, Holdren MS, Her MF, Gautam S, Magnuson M, Moses HL, Grady WM. Inactivation of TGF-beta signaling in hepatocytes results in an increased proliferative response after partial hepatectomy. Oncogene. 24: 3028-41. PMID 15735717 DOI: 10.1038/Sj.Onc.1208475  0.385
2005 Gloyn AL, Odili S, Zelent D, Buettger C, Castleden HA, Steele AM, Stride A, Shiota C, Magnuson MA, Lorini R, d'Annunzio G, Stanley CA, Kwagh J, van Schaftingen E, Veiga-da-Cunha M, et al. Insights into the structure and regulation of glucokinase from a novel mutation (V62M), which causes maturity-onset diabetes of the young. The Journal of Biological Chemistry. 280: 14105-13. PMID 15677479 DOI: 10.1074/Jbc.M413146200  0.31
2005 Jones JR, Shelton KD, Magnuson MA. Strategies for the use of site-specific recombinases in genome engineering. Methods in Molecular Medicine. 103: 245-57. PMID 15542911 DOI: 10.1385/1-59259-780-7:245  0.359
2004 Moates JM, Magnuson MA. The Pal elements in the upstream glucokinase promoter exhibit dyad symmetry and display cell-specific enhancer activity when multimerised. Diabetologia. 47: 1632-40. PMID 15365616 DOI: 10.1007/S00125-004-1497-1  0.424
2004 Schneider A, Guan Y, Zhang Y, Magnuson MA, Pettepher C, Loftin CD, Langenbach R, Breyer RM, Breyer MD. Generation of a conditional allele of the mouse prostaglandin EP4 receptor. Genesis (New York, N.Y. : 2000). 40: 7-14. PMID 15354288 DOI: 10.1002/Gene.20048  0.358
2004 Burgess SC, Hausler N, Merritt M, Jeffrey FM, Storey C, Milde A, Koshy S, Lindner J, Magnuson MA, Malloy CR, Sherry AD. Impaired tricarboxylic acid cycle activity in mouse livers lacking cytosolic phosphoenolpyruvate carboxykinase. The Journal of Biological Chemistry. 279: 48941-9. PMID 15347677 DOI: 10.1074/Jbc.M407120200  0.312
2004 Long Q, Shelton KD, Lindner J, Jones JR, Magnuson MA. Efficient DNA cassette exchange in mouse embryonic stem cells by staggered positive-negative selection. Genesis (New York, N.Y. : 2000). 39: 256-62. PMID 15286998 DOI: 10.1002/Gene.20053  0.369
2004 Gorogawa S, Fujitani Y, Kaneto H, Hazama Y, Watada H, Miyamoto Y, Takeda K, Akira S, Magnuson MA, Yamasaki Y, Kajimoto Y, Hori M. Insulin secretory defects and impaired islet architecture in pancreatic beta-cell-specific STAT3 knockout mice. Biochemical and Biophysical Research Communications. 319: 1159-70. PMID 15194489 DOI: 10.1016/J.Bbrc.2004.05.095  0.475
2004 Biondi CA, Gartside MG, Waring P, Loffler KA, Stark MS, Magnuson MA, Kay GF, Hayward NK. Conditional inactivation of the MEN1 gene leads to pancreatic and pituitary tumorigenesis but does not affect normal development of these tissues. Molecular and Cellular Biology. 24: 3125-31. PMID 15060136 DOI: 10.1128/Mcb.24.8.3125-3131.2004  0.377
2004 Dentin R, Pégorier JP, Benhamed F, Foufelle F, Ferré P, Fauveau V, Magnuson MA, Girard J, Postic C. Hepatic glucokinase is required for the synergistic action of ChREBP and SREBP-1c on glycolytic and lipogenic gene expression. The Journal of Biological Chemistry. 279: 20314-26. PMID 14985368 DOI: 10.1074/Jbc.M312475200  0.404
2004 Stiles B, Wang Y, Stahl A, Bassilian S, Lee WP, Kim YJ, Sherwin R, Devaskar S, Lesche R, Magnuson MA, Wu H. Live-specific deletion of negative regulator Pten results in fatty liver and insulin hypersensitivity Proceedings of the National Academy of Sciences of the United States of America. 101: 2082-2087. PMID 14769918 DOI: 10.1073/Pnas.0308617100  0.351
2004 Doliba NM, Qin W, Vatamaniuk MZ, Li C, Zelent D, Najafi H, Buettger CW, Collins HW, Carr RD, Magnuson MA, Matschinsky FM. Restitution of defective glucose-stimulated insulin release of sulfonylurea type 1 receptor knockout mice by acetylcholine. American Journal of Physiology. Endocrinology and Metabolism. 286: E834-43. PMID 14736703 DOI: 10.1152/Ajpendo.00292.2003  0.39
2004 Chu CA, Fujimoto Y, Igawa K, Grimsby J, Grippo JF, Magnuson MA, Cherrington AD, Shiota M. Rapid translocation of hepatic glucokinase in response to intraduodenal glucose infusion and changes in plasma glucose and insulin in conscious rats. American Journal of Physiology. Gastrointestinal and Liver Physiology. 286: G627-34. PMID 14656711 DOI: 10.1152/Ajpgi.00218.2003  0.311
2003 Miyatsuka T, Kaneto H, Kajimoto Y, Hirota S, Arakawa Y, Fujitani Y, Umayahara Y, Watada H, Yamasaki Y, Magnuson MA, Miyazaki J, Hori M. Ectopically expressed PDX-1 in liver initiates endocrine and exocrine pancreas differentiation but causes dysmorphogenesis. Biochemical and Biophysical Research Communications. 310: 1017-25. PMID 14550306 DOI: 10.1016/J.Bbrc.2003.09.108  0.51
2003 Rosen ED, Kulkarni RN, Sarraf P, Ozcan U, Okada T, Hsu CH, Eisenman D, Magnuson MA, Gonzalez FJ, Kahn CR, Spiegelman BM. Targeted elimination of peroxisome proliferator-activated receptor gamma in beta cells leads to abnormalities in islet mass without compromising glucose homeostasis. Molecular and Cellular Biology. 23: 7222-9. PMID 14517292 DOI: 10.1128/Mcb.23.20.7222-7229.2003  0.436
2003 Gloyn AL, Noordam K, Willemsen MA, Ellard S, Lam WW, Campbell IW, Midgley P, Shiota C, Buettger C, Magnuson MA, Matschinsky FM, Hattersley AT. Insights into the biochemical and genetic basis of glucokinase activation from naturally occurring hypoglycemia mutations. Diabetes. 52: 2433-40. PMID 12941786 DOI: 10.2337/Diabetes.52.9.2433  0.41
2003 Ristow M, Mulder H, Pomplun D, Schulz TJ, Müller-Schmehl K, Krause A, Fex M, Puccio H, Müller J, Isken F, Spranger J, Müller-Wieland D, Magnuson MA, Möhlig M, Koenig M, et al. Frataxin deficiency in pancreatic islets causes diabetes due to loss of β cell mass Journal of Clinical Investigation. 112: 527-534. PMID 12925693 DOI: 10.1172/Jci18107  0.431
2003 Martín J, Hunt SL, Dubus P, Sotillo R, Néhmé-Pélluard F, Magnuson MA, Parlow AF, Malumbres M, Ortega S, Barbacid M. Genetic rescue of Cdk4 null mice restores pancreatic beta-cell proliferation but not homeostatic cell number. Oncogene. 22: 5261-9. PMID 12917627 DOI: 10.1038/Sj.Onc.1206506  0.483
2003 Crabtree JS, Scacheri PC, Ward JM, McNally SR, Swain GP, Montagna C, Hager JH, Hanahan D, Edlund H, Magnuson MA, Garrett-Beal L, Burns AL, Ried T, Chandrasekharappa SC, Marx SJ, et al. Of mice and MEN1: Insulinomas in a conditional mouse knockout. Molecular and Cellular Biology. 23: 6075-85. PMID 12917331 DOI: 10.1128/Mcb.23.17.6075-6085.2003  0.443
2003 Schulla V, Renström E, Feil R, Feil S, Franklin I, Gjinovci A, Jing XJ, Laux D, Lundquist I, Magnuson MA, Obermüller S, Olofsson CS, Salehi A, Wendt A, Klugbauer N, et al. Impaired insulin secretion and glucose tolerance in beta cell-selective Ca(v)1.2 Ca2+ channel null mice. The Embo Journal. 22: 3844-54. PMID 12881419 DOI: 10.1093/Emboj/Cdg389  0.352
2003 Grimsby J, Sarabu R, Corbett WL, Haynes NE, Bizzarro FT, Coffey JW, Guertin KR, Hilliard DW, Kester RF, Mahaney PE, Marcus L, Qi L, Spence CL, Tengi J, Magnuson MA, et al. Allosteric activators of glucokinase: potential role in diabetes therapy. Science (New York, N.Y.). 301: 370-3. PMID 12869762 DOI: 10.1126/Science.1084073  0.405
2003 She P, Burgess SC, Shiota M, Flakoll P, Donahue EP, Malloy CR, Sherry AD, Magnuson MA. Mechanisms by which liver-specific PEPCK knockout mice preserve euglycemia during starvation. Diabetes. 52: 1649-54. PMID 12829628 DOI: 10.2337/Diabetes.52.7.1649  0.35
2003 Magnuson MA, She P, Shiota M. Gene-altered mice and metabolic flux control. The Journal of Biological Chemistry. 278: 32485-8. PMID 12788933 DOI: 10.1074/Jbc.R300020200  0.313
2003 Hara M, Wang X, Kawamura T, Bindokas VP, Dizon RF, Alcoser SY, Magnuson MA, Bell GI. Transgenic mice with green fluorescent protein-labeled pancreatic beta -cells. American Journal of Physiology. Endocrinology and Metabolism. 284: E177-83. PMID 12388130 DOI: 10.1152/Ajpendo.00321.2002  0.469
2002 Shiota C, Larsson O, Shelton KD, Shiota M, Efanov AM, Hoy M, Lindner J, Kooptiwut S, Juntti-Berggren L, Gromada J, Berggren PO, Magnuson MA. Sulfonylurea receptor type 1 knock-out mice have intact feeding-stimulated insulin secretion despite marked impairment in their response to glucose. The Journal of Biological Chemistry. 277: 37176-83. PMID 12149271 DOI: 10.1074/Jbc.M206757200  0.393
2002 Rizzo MA, Magnuson MA, Drain PF, Piston DW. A functional link between glucokinase binding to insulin granules and conformational alterations in response to glucose and insulin. The Journal of Biological Chemistry. 277: 34168-75. PMID 12101177 DOI: 10.1074/Jbc.M112478200  0.395
2002 Kulkarni RN, Holzenberger M, Shih DQ, Ozcan U, Stoffel M, Magnuson MA, Kahn CR. beta-cell-specific deletion of the Igf1 receptor leads to hyperinsulinemia and glucose intolerance but does not alter beta-cell mass. Nature Genetics. 31: 111-5. PMID 11923875 DOI: 10.1038/Ng872  0.446
2002 Christesen HB, Jacobsen BB, Odili S, Buettger C, Cuesta-Munoz A, Hansen T, Brusgaard K, Massa O, Magnuson MA, Shiota C, Matschinsky FM, Barbetti F. The second activating glucokinase mutation (A456V): implications for glucose homeostasis and diabetes therapy. Diabetes. 51: 1240-6. PMID 11916951 DOI: 10.2337/Diabetes.51.4.1240  0.341
2001 Sund NJ, Vatamaniuk MZ, Casey M, Ang SL, Magnuson MA, Stoffers DA, Matschinsky FM, Kaestner KH. Tissue-specific deletion of Foxa2 in pancreatic beta cells results in hyperinsulinemic hypoglycemia. Genes & Development. 15: 1706-15. PMID 11445544 DOI: 10.1101/Gad.901601  0.453
2001 Efanov AM, Høy M, Bränström R, Zaitsev SV, Magnuson MA, Efendic S, Gromada J, Berggren PO. The imidazoline RX871024 stimulates insulin secretion in pancreatic beta-cells from mice deficient in K(ATP) channel function. Biochemical and Biophysical Research Communications. 284: 918-22. PMID 11409880 DOI: 10.1006/Bbrc.2001.5068  0.378
2001 Njølstad PR, Søvik O, Cuesta-Muñoz A, Bjørkhaug L, Massa O, Barbetti F, Undlien DE, Shiota C, Magnuson MA, Molven A, Matschinsky FM, Bell GI. Neonatal diabetes mellitus due to complete glucokinase deficiency. The New England Journal of Medicine. 344: 1588-92. PMID 11372010 DOI: 10.1056/Nejm200105243442104  0.303
2001 Shiota M, Postic C, Fujimoto Y, Jetton TL, Dixon K, Pan D, Grimsby J, Grippo JF, Magnuson MA, Cherrington AD. Glucokinase gene locus transgenic mice are resistant to the development of obesity-induced type 2 diabetes. Diabetes. 50: 622-9. PMID 11246883 DOI: 10.2337/Diabetes.50.3.622  0.346
2001 Postic C, Shiota M, Magnuson MA. Cell-specific roles of glucokinase in glucose homeostasis. Recent Progress in Hormone Research. 56: 195-217. PMID 11237213 DOI: 10.1210/Rp.56.1.195  0.497
2000 Silva JP, Köhler M, Graff C, Oldfors A, Magnuson MA, Berggren PO, Larsson NG. Impaired insulin secretion and beta-cell loss in tissue-specific knockout mice with mitochondrial diabetes. Nature Genetics. 26: 336-40. PMID 11062475 DOI: 10.1038/81649  0.417
2000 She P, Shiota M, Shelton KD, Chalkley R, Postic C, Magnuson MA. Phosphoenolpyruvate carboxykinase is necessary for the integration of hepatic energy metabolism. Molecular and Cellular Biology. 20: 6508-17. PMID 10938127 DOI: 10.1128/Mcb.20.17.6508-6517.2000  0.342
2000 Sund NJ, Ang SL, Sackett SD, Shen W, Daigle N, Magnuson MA, Kaestner KH. Hepatocyte nuclear factor 3β (Foxa2) is dispensable for maintaining the differentiated state of the adult hepatocyte Molecular and Cellular Biology. 20: 5175-5183. PMID 10866673 DOI: 10.1128/Mcb.20.14.5175-5183.2000  0.368
2000 Wan YJ, An D, Cai Y, Repa JJ, Hung-Po Chen T, Flores M, Postic C, Magnuson MA, Chen J, Chien KR, French S, Mangelsdorf DJ, Sucov HM. Hepatocyte-specific mutation establishes retinoid X receptor alpha as a heterodimeric integrator of multiple physiological processes in the liver. Molecular and Cellular Biology. 20: 4436-44. PMID 10825207 DOI: 10.1128/Mcb.20.12.4436-4444.2000  0.306
2000 Grimsby J, Coffey JW, Dvorozniak MT, Magram J, Li G, Matschinsky FM, Shiota C, Kaur S, Magnuson MA, Grippo JF. Characterization of glucokinase regulatory protein-deficient mice. The Journal of Biological Chemistry. 275: 7826-31. PMID 10713097 DOI: 10.1074/Jbc.275.11.7826  0.409
2000 Gannon M, Shiota C, Postic C, Wright CV, Magnuson M. Analysis of the Cre-mediated recombination driven by rat insulin promoter in embryonic and adult mouse pancreas. Genesis (New York, N.Y. : 2000). 26: 139-42. PMID 10686610 DOI: 10.1002/(Sici)1526-968X(200002)26:2<139::Aid-Gene12>3.0.Co;2-7  0.35
2000 Michael M, Kulkarni RN, Postic C, Previs SF, Shulman GI, Magnuson MA, Kahn C. Loss of Insulin Signaling in Hepatocytes Leads to Severe Insulin Resistance and Progressive Hepatic Dysfunction Molecular Cell. 6: 87-97. DOI: 10.1016/S1097-2765(05)00015-8  0.377
1999 Lu JT, Son YJ, Lee J, Jetton TL, Shiota M, Moscoso L, Niswender KD, Loewy AD, Magnuson MA, Sanes JR, Emeson RB. Mice lacking alpha-calcitonin gene-related peptide exhibit normal cardiovascular regulation and neuromuscular development. Molecular and Cellular Neurosciences. 14: 99-120. PMID 10532808 DOI: 10.1006/Mcne.1999.0767  0.36
1999 Davis EA, Cuesta-Muñoz A, Raoul M, Buettger C, Sweet I, Moates M, Magnuson MA, Matschinsky FM. Mutants of glucokinase cause hypoglycaemia- and hyperglycaemia syndromes and their analysis illuminates fundamental quantitative concepts of glucose homeostasis. Diabetologia. 42: 1175-86. PMID 10525657 DOI: 10.1007/S001250051289  0.358
1999 Williams CP, Postic C, Robin D, Robin P, Parrinello J, Shelton K, Printz RL, Magnuson MA, Granner DK, Forest C, Chalkley R. Isolation and characterization of the mouse cytosolic phosphoenolpyruvate carboxykinase (GTP) gene: evidence for tissue-specific hypersensitive sites. Molecular and Cellular Endocrinology. 148: 67-77. PMID 10221772 DOI: 10.1016/S0303-7207(98)00234-2  0.355
1999 Kulkarni RN, Brüning JC, Winnay JN, Postic C, Magnuson MA, Kahn CR. Tissue-specific knockout of the insulin receptor in pancreatic beta cells creates an insulin secretory defect similar to that in type 2 diabetes. Cell. 96: 329-39. PMID 10025399 DOI: 10.1016/S0092-8674(00)80546-2  0.426
1999 Kupershmidt S, Yang T, Anderson ME, Wessels A, Niswender KD, Magnuson MA, Roden DM. Replacement by homologous recombination of the minK gene with lacZ reveals restriction of minK expression to the mouse cardiac conduction system. Circulation Research. 84: 146-52. PMID 9933245 DOI: 10.1161/01.Res.84.2.146  0.374
1999 Piston DW, Knobel SM, Postic C, Shelton KD, Magnuson MA. Adenovirus-mediated knockout of a conditional glucokinase gene in isolated pancreatic islets reveals an essential role for proximal metabolic coupling events in glucose-stimulated insulin secretion. The Journal of Biological Chemistry. 274: 1000-4. PMID 9873043 DOI: 10.1074/Jbc.274.2.1000  0.433
1999 Postic C, Shiota M, Niswender KD, Jetton TL, Chen Y, Moates JM, Shelton KD, Lindner J, Cherrington AD, Magnuson MA. Dual roles for glucokinase in glucose homeostasis as determined by liver and pancreatic beta cell-specific gene knock-outs using Cre recombinase. The Journal of Biological Chemistry. 274: 305-15. PMID 9867845 DOI: 10.1074/Jbc.274.1.305  0.513
1998 Jetton TL, Moates JM, Lindner J, Wright CV, Magnuson MA. Targeted oncogenesis of hormone-negative pancreatic islet progenitor cells. Proceedings of the National Academy of Sciences of the United States of America. 95: 8654-9. PMID 9671733 DOI: 10.1073/Pnas.95.15.8654  0.457
1998 Castillo SO, Baffi JS, Palkovits M, Goldstein DS, Kopin IJ, Witta J, Magnuson MA, Nikodem VM. Dopamine biosynthesis is selectively abolished in substantia nigra/ventral tegmental area but not in hypothalamic neurons in mice with targeted disruption of the Nurr1 gene. Molecular and Cellular Neurosciences. 11: 36-46. PMID 9608532 DOI: 10.1006/Mcne.1998.0673  0.336
1998 Matschinsky FM, Glaser B, Magnuson MA. Pancreatic beta-cell glucokinase: closing the gap between theoretical concepts and experimental realities. Diabetes. 47: 307-15. PMID 9519733 DOI: 10.2337/Diabetes.47.3.307  0.36
1997 Niswender KD, Shiota M, Postic C, Cherrington AD, Magnuson MA. Effects of increased glucokinase gene copy number on glucose homeostasis and hepatic glucose metabolism. The Journal of Biological Chemistry. 272: 22570-5. PMID 9278411 DOI: 10.1074/Jbc.272.36.22570  0.391
1997 Niswender KD, Postic C, Jetton TL, Bennett BD, Piston DW, Efrat S, Magnuson MA. Cell-specific expression and regulation of a glucokinase gene locus transgene. The Journal of Biological Chemistry. 272: 22564-9. PMID 9278410 DOI: 10.1074/Jbc.272.36.22564  0.459
1997 Ji QS, Winnier GE, Niswender KD, Horstman D, Wisdom R, Magnuson MA, Carpenter G. Essential role of the tyrosine kinase substrate phospholipase C-gamma1 in mammalian growth and development. Proceedings of the National Academy of Sciences of the United States of America. 94: 2999-3003. PMID 9096335 DOI: 10.1073/Pnas.94.7.2999  0.307
1997 Kesavan P, Wang L, Davis E, Cuesta A, Sweet I, Niswender K, Magnuson MA, Matschinsky FM. Structural instability of mutant beta-cell glucokinase: implications for the molecular pathogenesis of maturity-onset diabetes of the young (type-2). The Biochemical Journal. 322: 57-63. PMID 9078243 DOI: 10.1042/Bj3220057  0.386
1997 Niswender KD, Postic C, Shiota M, Jetton TL, Magnuson MA. Effects of altered glucokinase gene copy number on blood glucose homoeostasis. Biochemical Society Transactions. 25: 113-7. PMID 9056854 DOI: 10.1042/Bst0250113  0.44
1996 Moates JM, Shelton KD, Magnuson MA. Characterization of the Pal motifs in the upstream glucokinase promoter: binding of a cell type-specific protein complex correlates with transcriptional activation. Molecular Endocrinology (Baltimore, Md.). 10: 723-31. PMID 8776732 DOI: 10.1210/Mend.10.6.8776732  0.423
1996 Bennett BD, Jetton TL, Ying G, Magnuson MA, Piston DW. Quantitative subcellular imaging of glucose metabolism within intact pancreatic islets. The Journal of Biological Chemistry. 271: 3647-51. PMID 8631975 DOI: 10.1074/Jbc.271.7.3647  0.407
1996 Parsa R, Decaux JF, Bossard P, Robey BR, Magnuson MA, Granner DK, Girard J. Induction of the glucokinase gene by insulin in cultured neonatal rat hepatocytes. Relationship with DNase-I hypersensitive sites and functional analysis of a putative insulin-response element. European Journal of Biochemistry. 236: 214-21. PMID 8617267 DOI: 10.1111/J.1432-1033.1996.00214.X  0.365
1995 Postic C, Niswender KD, Decaux JF, Parsa R, Shelton KD, Gouhot B, Pettepher CC, Granner DK, Girard J, Magnuson MA. Cloning and characterization of the mouse glucokinase gene locus and identification of distal liver-specific DNase I hypersensitive sites. Genomics. 29: 740-50. PMID 8575768 DOI: 10.1006/Geno.1995.9943  0.383
1995 Liang Y, Kesavan P, Wang LQ, Niswender K, Tanizawa Y, Permutt MA, Magnuson MA, Matschinsky FM. Variable effects of maturity-onset-diabetes-of-youth (MODY)-associated glucokinase mutations on substrate interactions and stability of the enzyme. The Biochemical Journal. 167-73. PMID 7619052 DOI: 10.1042/Bj3090167  0.354
1995 Williams CP, Granner DK, Magnuson MA, Chalkley R. Cell-Specific Differences in DNase I Hypersensitivity between the Two Promoters of the Rat Glucokinase Gene Biochemical and Biophysical Research Communications. 215: 272-279. PMID 7575601 DOI: 10.1006/Bbrc.1995.2462  0.447
1994 Meyrick B, Magnuson MA. Identification and functional characterization of the bovine manganous superoxide dismutase promoter. American Journal of Respiratory Cell and Molecular Biology. 10: 113-21. PMID 8292376 DOI: 10.1165/Ajrcmb.10.1.8292376  0.328
1994 Liang Y, Jetton TL, Zimmerman EC, Najafi H, Berner DK, Matschinsky FM, Magnuson MA. Effects of glucose on insulin secretion, glucokinase activity, and transgene expression in transgenic mouse islets containing an upstream glucokinase promoter-human growth hormone fusion gene. Diabetes. 43: 1138-45. PMID 8070614 DOI: 10.2337/Diab.43.9.1138  0.424
1994 Franklin AJ, Jetton TL, Shelton KD, Magnuson MA. BZP, a novel serum-responsive zinc finger protein that inhibits gene transcription. Molecular and Cellular Biology. 14: 6773-88. PMID 7935395 DOI: 10.1128/Mcb.14.10.6773  0.353
1994 Morita H, Yano Y, Niswender KD, May JM, Whitesell RR, Wu L, Printz RL, Granner DK, Magnuson MA, Powers AC. Coexpression of glucose transporters and glucokinase in Xenopus oocytes indicates that both glucose transport and phosphorylation determine glucose utilization. The Journal of Clinical Investigation. 94: 1373-82. PMID 7929812 DOI: 10.1172/Jci117472  0.347
1994 Efrat S, Leiser M, Wu YJ, Fusco-DeMane D, Emran OA, Surana M, Jetton TL, Magnuson MA, Weir G, Fleischer N. Ribozyme-mediated attenuation of pancreatic beta-cell glucokinase expression in transgenic mice results in impaired glucose-induced insulin secretion. Proceedings of the National Academy of Sciences of the United States of America. 91: 2051-5. PMID 7510884 DOI: 10.1073/Pnas.91.6.2051  0.454
1993 Brigham KL, Meyrick B, Christman B, Conary JT, King G, Berry LC, Magnuson MA. Expression of human growth hormone fusion genes in cultured lung endothelial cells and in the lungs of mice. American Journal of Respiratory Cell and Molecular Biology. 8: 209-13. PMID 7678969 DOI: 10.1165/Ajrcmb/8.2.209  0.337
1992 Magnuson MA. Tissue-specific regulation of glucokinase gene expression. Journal of Cellular Biochemistry. 48: 115-21. PMID 1618925 DOI: 10.1002/Jcb.240480202  0.451
1992 Liang Y, Najafi H, Smith RM, Zimmerman EC, Magnuson MA, Tal M, Matschinsky FM. Concordant glucose induction of glucokinase, glucose usage, and glucose-stimulated insulin release in pancreatic islets maintained in organ culture. Diabetes. 41: 792-806. PMID 1612193 DOI: 10.2337/Diab.41.7.792  0.346
1992 Jetton TL, Magnuson MA. Heterogeneous expression of glucokinase among pancreatic beta cells. Proceedings of the National Academy of Sciences of the United States of America. 89: 2619-23. PMID 1557365 DOI: 10.1073/Pnas.89.7.2619  0.436
1992 Short MK, Clouthier DE, Schaefer IM, Hammer RE, Magnuson MA, Beale EG. Tissue-specific, developmental, hormonal, and dietary regulation of rat phosphoenolpyruvate carboxykinase-human growth hormone fusion genes in transgenic mice. Molecular and Cellular Biology. 12: 1007-20. PMID 1545785 DOI: 10.1128/Mcb.12.3.1007  0.396
1992 Shelton KD, Franklin AJ, Khoor A, Beechem J, Magnuson MA. Multiple elements in the upstream glucokinase promoter contribute to transcription in insulinoma cells. Molecular and Cellular Biology. 12: 4578-89. PMID 1406648 DOI: 10.1128/Mcb.12.10.4578  0.439
1990 Magnuson MA. Glucokinase gene structure. Functional implications of molecular genetic studies. Diabetes. 39: 523-7. PMID 2185104 DOI: 10.2337/Diab.39.5.523  0.465
1990 Forest CD, O'Brien RM, Lucas PC, Magnuson MA, Granner DK. Regulation of phosphoenolpyruvate carboxykinase gene expression by insulin. Use of the stable transfection approach to locate an insulin responsive sequence Molecular Endocrinology. 4: 1302-1310. PMID 2172798 DOI: 10.1210/Mend-4-9-1302  0.407
1990 O'Brien RM, Lucas PC, Forest CD, Magnuson MA, Granner DK. Identification of a sequence in the PEPCK gene that mediates a negative effect of insulin on transcription Science. 249: 533-537. PMID 2166335 DOI: 10.1126/Science.2166335  0.358
1989 Brigham KL, Meyrick B, Christman B, Magnuson M, King G, Berry LC. In vivo transfection of murine lungs with a functioning prokaryotic gene using a liposome vehicle. The American Journal of the Medical Sciences. 298: 278-81. PMID 2801762 DOI: 10.1097/00000441-198910000-00013  0.317
1989 Magnuson MA, Andreone TL, Printz RL, Koch S, Granner DK. Rat glucokinase gene: Structure and regulation by insulin Proceedings of the National Academy of Sciences of the United States of America. 86: 4838-4842. PMID 2662183 DOI: 10.1073/Pnas.86.13.4838  0.374
1988 Petersen DD, Magnuson MA, Granner DK. Location and characterization of two widely separated glucocorticoid response elements in the phosphoenolpyruvate carboxykinase gene Molecular and Cellular Biology. 8: 96-104. PMID 3422101 DOI: 10.1128/Mcb.8.1.96  0.303
1988 Quinn PG, Wong TW, Magnuson MA, Shabb JB, Granner DK. Identification of basal and cyclic AMP regulatory elements in the promoter of the phosphoenolpyruvate carboxykinase gene. Molecular and Cellular Biology. 8: 3467-75. PMID 2850495 DOI: 10.1128/Mcb.8.8.3467  0.316
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