Christopher B. Newgard - Publications

Pharmacology Duke University, Durham, NC 
Molecular Biology, Cell Biology, Pharmacology

125 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Softic S, Meyer JG, Wang GX, Gupta MK, Batista TM, Lauritzen HPMM, Fujisaka S, Serra D, Herrero L, Willoughby J, Fitzgerald K, Ilkayeva O, Newgard CB, Gibson BW, Schilling B, et al. Dietary Sugars Alter Hepatic Fatty Acid Oxidation via Transcriptional and Post-translational Modifications of Mitochondrial Proteins. Cell Metabolism. 30: 735-753.e4. PMID 31577934 DOI: 10.1016/j.cmet.2019.09.003  0.36
2019 Kavanagh K, Day SM, Pait MC, Mortiz WR, Newgard CB, Ilkayeva O, Mcclain DA, Macauley SL. Type-2-Diabetes Alters CSF but Not Plasma Metabolomic and AD Risk Profiles in Vervet Monkeys. Frontiers in Neuroscience. 13: 843. PMID 31555072 DOI: 10.3389/fnins.2019.00843  0.36
2019 Kadakia R, Talbot O, Kuang A, Bain JR, Muehlbauer MJ, Stevens RD, Ilkayeva OR, Lowe LP, Metzger BE, Newgard CB, Scholtens DM, Lowe WL. Cord Blood Metabolomics: Association With Newborn Anthropometrics and C-Peptide Across Ancestries. The Journal of Clinical Endocrinology and Metabolism. 104: 4459-4472. PMID 31498869 DOI: 10.1210/jc.2019-00238  0.32
2019 Gehrig JL, Venkatesh S, Chang HW, Hibberd MC, Kung VL, Cheng J, Chen RY, Subramanian S, Cowardin CA, Meier MF, O'Donnell D, Talcott M, Spears LD, Semenkovich CF, Henrissat B, ... ... Newgard CB, et al. Effects of microbiota-directed foods in gnotobiotic animals and undernourished children. Science (New York, N.Y.). 365. PMID 31296738 DOI: 10.1126/science.aau4732  0.36
2019 Younge NE, Newgard CB, Cotten CM, Goldberg RN, Muehlbauer MJ, Bain JR, Stevens RD, O'Connell TM, Rawls JF, Seed PC, Ashley PL. Disrupted Maturation of the Microbiota and Metabolome among Extremely Preterm Infants with Postnatal Growth Failure. Scientific Reports. 9: 8167. PMID 31160673 DOI: 10.1038/s41598-019-44547-y  0.32
2018 Haldeman JM, Conway AE, Arlotto ME, Slentz DH, Muoio DM, Becker TC, Newgard CB. Creation of versatile cloning platforms for transgene expression and dCas9-based epigenome editing. Nucleic Acids Research. PMID 30590691 DOI: 10.1093/nar/gky1286  0.36
2018 Meyer JG, Softic S, Basisty N, Rardin MJ, Verdin E, Gibson BW, Ilkayeva O, Newgard CB, Kahn CR, Schilling B. Temporal dynamics of liver mitochondrial protein acetylation and succinylation and metabolites due to high fat diet and/or excess glucose or fructose. Plos One. 13: e0208973. PMID 30586434 DOI: 10.1371/journal.pone.0208973  0.36
2018 Kadakia R, Nodzenski M, Talbot O, Kuang A, Bain JR, Muehlbauer MJ, Stevens RD, Ilkayeva OR, O'Neal SK, Lowe LP, Metzger BE, Newgard CB, Scholtens DM, Lowe WL. Maternal metabolites during pregnancy are associated with newborn outcomes and hyperinsulinaemia across ancestries. Diabetologia. PMID 30483859 DOI: 10.1007/s00125-018-4781-1  0.32
2018 Ravi S, Parry TL, Willis MS, Lockyer P, Patterson C, Bain JR, Stevens RD, Ilkayeva OR, Newgard CB, Schisler JC. Adverse Effects of Fenofibrate in Mice Deficient in the Protein Quality Control Regulator, CHIP. Journal of Cardiovascular Development and Disease. 5. PMID 30111698 DOI: 10.3390/jcdd5030043  0.32
2018 Peterson BS, Campbell JE, Ilkayeva O, Grimsrud PA, Hirschey MD, Newgard CB. Remodeling of the Acetylproteome by SIRT3 Manipulation Fails to Affect Insulin Secretion or β Cell Metabolism in the Absence of Overnutrition. Cell Reports. 24: 209-223.e6. PMID 29972782 DOI: 10.1016/j.celrep.2018.05.088  0.36
2018 White PJ, McGarrah RW, Grimsrud PA, Tso SC, Yang WH, Haldeman JM, Grenier-Larouche T, An J, Lapworth AL, Astapova I, Hannou SA, George T, Arlotto M, Olson LB, Lai M, ... ... Newgard CB, et al. The BCKDH Kinase and Phosphatase Integrate BCAA and Lipid Metabolism via Regulation of ATP-Citrate Lyase. Cell Metabolism. PMID 29779826 DOI: 10.1016/j.cmet.2018.04.015  0.36
2018 An J, Wang L, Patnode ML, Ridaura VK, Haldeman JM, Stevens RD, Ilkayeva O, Bain JR, Muehlbauer MJ, Glynn EL, Thomas S, Muoio D, Summers SA, Vath JE, Hughes TE, ... ... Newgard CB, et al. Physiological mechanisms of sustained fumagillin-induced weight loss. Jci Insight. 3. PMID 29515039 DOI: 10.1172/jci.insight.99453  0.36
2018 Softic S, Gupta MK, Wang GX, Fujisaka S, O'Neill BT, Rao TN, Willoughby J, Harbison C, Fitzgerald K, Ilkayeva O, Newgard CB, Cohen DE, Kahn CR. Divergent effects of glucose and fructose on hepatic lipogenesis and insulin signaling. The Journal of Clinical Investigation. 128: 1199. PMID 29493547 DOI: 10.1172/JCI99009  0.36
2018 Sugi K, Hsieh PN, Ilkayeva O, Shelkay S, Moroney B, Baadh P, Haynes B, Pophal M, Fan L, Newgard CB, Prosdocimo DA, Jain MK. Kruppel-like factor 15 is required for the cardiac adaptive response to fasting. Plos One. 13: e0192376. PMID 29408889 DOI: 10.1371/journal.pone.0192376  0.36
2018 Lowe WL, Bain JR, Nodzenski M, Reisetter AC, Muehlbauer MJ, Stevens RD, Ilkayeva OR, Lowe LP, Metzger BE, Newgard CB, Scholtens DM. Erratum. Maternal BMI and Glycemia Impact the Fetal Metabolome. Diabetes Care 2017;40:902-910. Diabetes Care. PMID 29311154 DOI: 10.2337/dc18-er03b  0.32
2017 Softic S, Gupta MK, Wang GX, Fujisaka S, O'Neill BT, Rao TN, Willoughby J, Harbison C, Fitzgerald K, Ilkayeva O, Newgard CB, Cohen DE, Kahn CR. Divergent effects of glucose and fructose on hepatic lipogenesis and insulin signaling. The Journal of Clinical Investigation. PMID 28972537 DOI: 10.1172/JCI94585  0.36
2017 Jensen MV, Gooding JR, Ferdaoussi M, Dai XQ, Peterson BS, MacDonald PE, Newgard CB. Metabolomics applied to islet nutrient sensing mechanisms. Diabetes, Obesity & Metabolism. 19: 90-94. PMID 28880482 DOI: 10.1111/dom.13010  0.36
2017 Luo N, Craig D, Ilkayeva O, Muehlbauer M, Kraus WE, Newgard CB, Shah SH, Rajagopal S. Plasma acylcarnitines are associated with pulmonary hypertension. Pulmonary Circulation. 7: 211-218. PMID 28680580 DOI: 10.1086/690554  0.36
2017 Jacob S, Nodzenski M, Reisetter AC, Bain JR, Muehlbauer MJ, Stevens RD, Ilkayeva OR, Lowe LP, Metzger BE, Newgard CB, Scholtens DM, Lowe WL. Targeted Metabolomics Demonstrates Distinct and Overlapping Maternal Metabolites Associated With BMI, Glucose, and Insulin Sensitivity During Pregnancy Across Four Ancestry Groups. Diabetes Care. 40: 911-919. PMID 28637889 DOI: 10.2337/dc16-2453  0.32
2017 Lowe WL, Bain JR, Nodzenski M, Reisetter AC, Muehlbauer MJ, Stevens RD, Ilkayeva OR, Lowe LP, Metzger BE, Newgard CB, Scholtens DM. Maternal BMI and Glycemia Impact the Fetal Metabolome. Diabetes Care. 40: 902-910. PMID 28637888 DOI: 10.2337/dc16-2452  0.32
2017 Wang H, Anstrom K, Ilkayeva O, Muehlbauer MJ, Bain JR, McNulty S, Newgard CB, Kraus WE, Hernandez A, Felker GM, Redfield M, Shah SH. Sildenafil Treatment in Heart Failure With Preserved Ejection Fraction: Targeted Metabolomic Profiling in the RELAX Trial. Jama Cardiology. PMID 28492915 DOI: 10.1001/jamacardio.2017.1239  0.36
2017 Reisetter AC, Muehlbauer MJ, Bain JR, Nodzenski M, Stevens RD, Ilkayeva O, Metzger BE, Newgard CB, Lowe WL, Scholtens DM. Mixture model normalization for non-targeted gas chromatography/mass spectrometry metabolomics data. Bmc Bioinformatics. 18: 84. PMID 28153035 DOI: 10.1186/s12859-017-1501-7  0.36
2016 Griffin NW, Ahern PP, Cheng J, Heath AC, Ilkayeva O, Newgard CB, Fontana L, Gordon JI. Prior Dietary Practices and Connections to a Human Gut Microbial Metacommunity Alter Responses to Diet Interventions. Cell Host & Microbe. PMID 28041931 DOI: 10.1016/j.chom.2016.12.006  0.36
2016 Sandler V, Reisetter AC, Bain JR, Muehlbauer MJ, Nodzenski M, Stevens RD, Ilkayeva O, Lowe LP, Metzger BE, Newgard CB, Scholtens DM, Lowe WL. Associations of maternal BMI and insulin resistance with the maternal metabolome and newborn outcomes. Diabetologia. PMID 27981358 DOI: 10.1007/s00125-016-4182-2  0.36
2016 Wagner VE, Dey N, Guruge J, Hsiao A, Ahern PP, Semenkovich NP, Blanton LV, Cheng J, Griffin N, Stappenbeck TS, Ilkayeva O, Newgard CB, Petri W, Haque R, Ahmed T, et al. Effects of a gut pathobiont in a gnotobiotic mouse model of childhood undernutrition. Science Translational Medicine. 8: 366ra164. PMID 27881825 DOI: 10.1126/scitranslmed.aah4669  0.36
2016 Bradley T, Yang G, Ilkayeva O, Holl TM, Zhang R, Zhang J, Santra S, Fox CB, Reed SG, Parks R, Bowman CM, Bouton-Verville H, Sutherland LL, Scearce RM, Vandergrift N, ... ... Newgard CB, et al. HIV-1 Envelope Mimicry of Host Enzyme Kynureninase Does Not Disrupt Tryptophan Metabolism. Journal of Immunology (Baltimore, Md. : 1950). PMID 27849170 DOI: 10.4049/jimmunol.1601484  0.36
2016 Gurley JM, Ilkayeva O, Jackson RM, Griesel BA, White P, Matsuzaki S, Qaisar R, Van Remmen H, Humphries KM, Newgard CB, Olson AL. Enhanced GLUT4-Dependent Glucose Transport Relieves Nutrient Stress in Obese Mice Through Changes in Lipid and Amino Acid Metabolism. Diabetes. PMID 27679559 DOI: 10.2337/db16-0709  0.36
2016 Hayes HL, Zhang L, Becker TC, Haldeman J, Stephens SB, Arlotto M, Moss LG, Newgard CB, Hohmeier HE. A Pdx-1-regulated soluble factor activates rat and human islet cell proliferation. Molecular and Cellular Biology. PMID 27620967 DOI: 10.1128/MCB.00103-16  0.36
2016 Hunter WG, Kelly JP, McGarrah RW, Khouri MG, Craig D, Haynes C, Ilkayeva O, Stevens RD, Bain JR, Muehlbauer MJ, Newgard CB, Felker GM, Hernandez AF, Velazquez EJ, Kraus WE, et al. Metabolomic Profiling Identifies Novel Circulating Biomarkers of Mitochondrial Dysfunction Differentially Elevated in Heart Failure With Preserved Versus Reduced Ejection Fraction: Evidence for Shared Metabolic Impairments in Clinical Heart Failure. Journal of the American Heart Association. 5. PMID 27473038 DOI: 10.1161/JAHA.115.003190  0.36
2016 White PJ, Lapworth AL, An J, Wang L, McGarrah RW, Stevens RD, Ilkayeva O, George T, Muehlbauer MJ, Bain JR, Trimmer JK, Brosnan MJ, Rolph TP, Newgard CB. Branched-chain amino acid restriction in Zucker-fatty rats improves muscle insulin sensitivity by enhancing efficiency of fatty acid oxidation and acyl-glycine export. Molecular Metabolism. 5: 538-51. PMID 27408778 DOI: 10.1016/j.molmet.2016.04.006  0.36
2016 Kucejova B, Duarte J, Satapati S, Fu X, Ilkayeva O, Newgard CB, Brugarolas J, Burgess SC. Hepatic mTORC1 Opposes Impaired Insulin Action to Control Mitochondrial Metabolism in Obesity. Cell Reports. PMID 27346353 DOI: 10.1016/j.celrep.2016.06.006  0.36
2016 Scholtens DM, Bain JR, Reisetter AC, Muehlbauer MJ, Nodzenski M, Stevens RD, Ilkayeva O, Lowe LP, Metzger BE, Newgard CB, Lowe WL. Metabolic networks and metabolites underlie associations between maternal glucose during pregnancy and newborn size at birth. Diabetes. PMID 27207545 DOI: 10.2337/db15-1748  0.36
2016 Quinones QJ, Zhang Z, Ma Q, Smith MP, Soderblom E, Moseley MA, Bain J, Newgard CB, Muehlbauer MJ, Hirschey M, Drew KL, Barnes BM, Podgoreanu MV. Proteomic Profiling Reveals Adaptive Responses to Surgical Myocardial Ischemia-Reperfusion in Hibernating Arctic Ground Squirrels Compared to Rats. Anesthesiology. 124: 1296-310. PMID 27187119 DOI: 10.1097/ALN.0000000000001113  0.36
2016 Sun H, Olson KC, Gao C, Prosdocimo DA, Zhou M, Wang Z, Jeyaraj D, Youn JY, Ren S, Liu Y, Rau CD, Shah S, Ilkayeva O, Gui WJ, Williams NS, ... ... Newgard CB, et al. Catabolic Defect of Branched-Chain Amino Acids Promotes Heart Failure. Circulation. PMID 27059949 DOI: 10.1161/CIRCULATIONAHA.115.020226  0.36
2016 Zhang W, Bu SY, Mashek MT, O-Sullivan I, Sibai Z, Khan SA, Ilkayeva O, Newgard CB, Mashek DG, Unterman TG. Integrated Regulation of Hepatic Lipid and Glucose Metabolism by Adipose Triacylglycerol Lipase and FoxO Proteins. Cell Reports. PMID 27050511 DOI: 10.1016/j.celrep.2016.03.021  0.36
2016 Marcelo KL, Ribar T, Means CR, Tsimelzon A, Stevens RD, Ilkayeva O, Bain JR, Hilsenbeck SG, Newgard CB, Means AR, York B. Research Resource: Roles for Calcium/Calmodulin-Dependent Protein Kinase Kinase 2 (CaMKK2) in Systems Metabolism. Molecular Endocrinology (Baltimore, Md.). me20161021. PMID 27003444 DOI: 10.1210/me.2016-1021  0.36
2016 Kraus WE, Pieper CF, Huffman KM, Thompson DK, Kraus VB, Morey MC, Cohen HJ, Ravussin E, Redman LM, Bain JR, Stevens RD, Newgard CB. Association of Plasma Small-Molecule Intermediate Metabolites With Age and Body Mass Index Across Six Diverse Study Populations. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. PMID 26984390 DOI: 10.1093/gerona/glw031  0.32
2016 Blanton LV, Charbonneau MR, Salih T, Barratt MJ, Venkatesh S, Ilkaveya O, Subramanian S, Manary MJ, Trehan I, Jorgensen JM, Fan YM, Henrissat B, Leyn SA, Rodionov DA, Osterman AL, ... ... Newgard CB, et al. Gut bacteria that prevent growth impairments transmitted by microbiota from malnourished children. Science (New York, N.Y.). 351. PMID 26912898 DOI: 10.1126/science.aad3311  0.36
2016 Charbonneau MR, O'Donnell D, Blanton LV, Totten SM, Davis JC, Barratt MJ, Cheng J, Guruge J, Talcott M, Bain JR, Muehlbauer MJ, Ilkayeva O, Wu C, Struckmeyer T, Barile D, ... ... Newgard CB, et al. Sialylated Milk Oligosaccharides Promote Microbiota-Dependent Growth in Models of Infant Undernutrition. Cell. PMID 26898329 DOI: 10.1016/j.cell.2016.01.024  0.36
2016 Sommer F, Ståhlman M, Ilkayeva O, Arnemo JM, Kindberg J, Josefsson J, Newgard CB, Fröbert O, Bäckhed F. The Gut Microbiota Modulates Energy Metabolism in the Hibernating Brown Bear Ursus arctos. Cell Reports. 14: 1655-61. PMID 26854221 DOI: 10.1016/j.celrep.2016.01.026  0.36
2015 Gooding JR, Jensen MV, Dai X, Wenner BR, Lu D, Arumugam R, Ferdaoussi M, MacDonald PE, Newgard CB. Adenylosuccinate Is an Insulin Secretagogue Derived from Glucose-Induced Purine Metabolism. Cell Reports. PMID 26411681 DOI: 10.1016/j.celrep.2015.08.072  0.36
2015 Ferdaoussi M, Dai X, Jensen MV, Wang R, Peterson BS, Huang C, Ilkayeva O, Smith N, Miller N, Hajmrle C, Spigelman AF, Wright RC, Plummer G, Suzuki K, Mackay JP, ... ... Newgard CB, et al. Isocitrate-to-SENP1 signaling amplifies insulin secretion and rescues dysfunctional β cells. The Journal of Clinical Investigation. PMID 26389676 DOI: 10.1172/JCI82498  0.36
2015 Wagner M, Choi S, Panzitt K, Mamrosh JL, Man Lee J, Zaufel A, Xiao R, Wooton-Kee R, Ståhlman M, Newgard CB, Borén J, Moore DD. LRH-1 is a critical determinant of methyl-pool metabolism. Hepatology (Baltimore, Md.). PMID 26267291 DOI: 10.1002/hep.28124  0.36
2015 Glynn EL, Piner LW, Huffman KM, Slentz CA, Elliot-Penry L, AbouAssi H, White PJ, Bain JR, Muehlbauer MJ, Ilkayeva OR, Stevens RD, Porter Starr KN, Bales CW, Volpi E, Brosnan MJ, ... ... Newgard CB, et al. Impact of combined resistance and aerobic exercise training on branched-chain amino acid turnover, glycine metabolism and insulin sensitivity in overweight humans. Diabetologia. 58: 2324-35. PMID 26254576 DOI: 10.1007/s00125-015-3705-6  0.36
2015 Rodríguez JE, Liao JY, He J, Schisler JC, Newgard CB, Drujan D, Glass DL, Frederick CB, Yoder BC, Lalush DS, Patterson C, Willis MS. The Ubiquitin Ligase MuRF1 Regulates PPARα Activity in the Heart by Enhancing Nuclear Export via Monoubiquitination. Molecular and Cellular Endocrinology. PMID 26116825 DOI: 10.1016/j.mce.2015.06.008  0.36
2015 Gooding JR, Jensen MV, Newgard CB. Metabolomics applied to the pancreatic islet. Archives of Biochemistry and Biophysics. PMID 26116790 DOI: 10.1016/  0.36
2015 Zhang M, Qiu Q, Li Z, Sachdeva M, Min H, Cardona DM, DeLaney TF, Han T, Ma Y, Luo L, Ilkayeva OR, Lui K, Nichols AG, Newgard CB, Kastan MB, et al. HIF-1 Alpha Regulates the Response of Primary Sarcomas to Radiation Therapy through a Cell Autonomous Mechanism. Radiation Research. 183: 594-609. PMID 25973951 DOI: 10.1667/RR14016.1  0.36
2015 Shah SH, Newgard CB. Integrated metabolomics and genomics: systems approaches to biomarkers and mechanisms of cardiovascular disease. Circulation. Cardiovascular Genetics. 8: 410-9. PMID 25901039 DOI: 10.1161/CIRCGENETICS.114.000223  0.36
2015 Kang YK, Putluri N, Maity S, Tsimelzon A, Ilkayeva O, Mo Q, Lonard D, Michailidis G, Sreekumar A, Newgard CB, Wang M, Tsai SY, Tsai MJ, O'Malley BW. CAPER is vital for energy and redox homeostasis by integrating glucose-induced mitochondrial functions via ERR-α-Gabpa and stress-induced adaptive responses via NF-κB-cMYC. Plos Genetics. 11: e1005116. PMID 25830341 DOI: 10.1371/journal.pgen.1005116  0.36
2015 Ali S, Ussher JR, Baggio LL, Kabir MG, Charron MJ, Ilkayeva O, Newgard CB, Drucker DJ. Cardiomyocyte glucagon receptor signaling modulates outcomes in mice with experimental myocardial infarction. Molecular Metabolism. 4: 132-43. PMID 25685700 DOI: 10.1016/j.molmet.2014.11.005  0.36
2015 Guo C, Ludvik AE, Arlotto ME, Hayes MG, Armstrong LL, Scholtens DM, Brown CD, Newgard CB, Becker TC, Layden BT, Lowe WL, Reddy TE. Coordinated regulatory variation associated with gestational hyperglycaemia regulates expression of the novel hexokinase HKDC1. Nature Communications. 6: 6069. PMID 25648650 DOI: 10.1038/ncomms7069  0.36
2015 Gerriets VA, Kishton RJ, Nichols AG, Macintyre AN, Inoue M, Ilkayeva O, Winter PS, Liu X, Priyadharshini B, Slawinska ME, Haeberli L, Huck C, Turka LA, Wood KC, Hale LP, ... ... Newgard CB, et al. Metabolic programming and PDHK1 control CD4+ T cell subsets and inflammation. The Journal of Clinical Investigation. 125: 194-207. PMID 25437876 DOI: 10.1172/JCI76012  0.36
2015 Palmer ND, Stevens RD, Antinozzi PA, Anderson A, Bergman RN, Wagenknecht LE, Newgard CB, Bowden DW. Metabolomic profile associated with insulin resistance and conversion to diabetes in the Insulin Resistance Atherosclerosis Study. The Journal of Clinical Endocrinology and Metabolism. 100: E463-8. PMID 25423564 DOI: 10.1210/jc.2014-2357  0.36
2015 Li LO, Grevengoed TJ, Paul DS, Ilkayeva O, Koves TR, Pascual F, Newgard CB, Muoio DM, Coleman RA. Compartmentalized acyl-CoA metabolism in skeletal muscle regulates systemic glucose homeostasis. Diabetes. 64: 23-35. PMID 25071025 DOI: 10.2337/db13-1070  0.36
2014 Baskin KK, Grueter CE, Kusminski CM, Holland WL, Bookout AL, Satapati S, Kong YM, Burgess SC, Malloy CR, Scherer PE, Newgard CB, Bassel-Duby R, Olson EN. MED13-dependent signaling from the heart confers leanness by enhancing metabolism in adipose tissue and liver. Embo Molecular Medicine. 6: 1610-21. PMID 25422356 DOI: 10.15252/emmm.201404218  0.36
2014 Shin AC, Fasshauer M, Filatova N, Grundell LA, Zielinski E, Zhou JY, Scherer T, Lindtner C, White PJ, Lapworth AL, Ilkayeva O, Knippschild U, Wolf AM, Scheja L, Grove KL, ... ... Newgard CB, et al. Brain insulin lowers circulating BCAA levels by inducing hepatic BCAA catabolism. Cell Metabolism. 20: 898-909. PMID 25307860 DOI: 10.1016/j.cmet.2014.09.003  0.36
2014 Tannour-Louet M, York B, Tang K, Stashi E, Bouguerra H, Zhou S, Yu H, Wong LJ, Stevens RD, Xu J, Newgard CB, O'Malley BW, Louet JF. Hepatic SRC-1 activity orchestrates transcriptional circuitries of amino acid pathways with potential relevance for human metabolic pathogenesis. Molecular Endocrinology (Baltimore, Md.). 28: 1707-18. PMID 25148457 DOI: 10.1210/me.2014-1083  0.32
2014 Gupte AA, Hamilton DJ, Cordero-Reyes AM, Youker KA, Yin Z, Estep JD, Stevens RD, Wenner B, Ilkayeva O, Loebe M, Peterson LE, Lyon CJ, Wong ST, Newgard CB, Torre-Amione G, et al. Mechanical unloading promotes myocardial energy recovery in human heart failure. Circulation. Cardiovascular Genetics. 7: 266-76. PMID 24825877 DOI: 10.1161/CIRCGENETICS.113.000404  0.36
2014 Tripathy S, Lytle KA, Stevens RD, Bain JR, Newgard CB, Greenberg AS, Huang LS, Jump DB. Fatty acid elongase-5 (Elovl5) regulates hepatic triglyceride catabolism in obese C57BL/6J mice. Journal of Lipid Research. 55: 1448-1464. PMID 24814977 DOI: 10.1194/jlr.M050062  0.36
2014 Tessem JS, Moss LG, Chao LC, Arlotto M, Lu D, Jensen MV, Stephens SB, Tontonoz P, Hohmeier HE, Newgard CB. Nkx6.1 regulates islet β-cell proliferation via Nr4a1 and Nr4a3 nuclear receptors. Proceedings of the National Academy of Sciences of the United States of America. 111: 5242-7. PMID 24706823 DOI: 10.1073/pnas.1320953111  0.36
2014 Bartz S, Mody A, Hornik C, Bain J, Muehlbauer M, Kiyimba T, Kiboneka E, Stevens R, Bartlett J, St Peter JV, Newgard CB, Freemark M. Severe acute malnutrition in childhood: Hormonal and metabolic status at presentation, response to treatment, and predictors of mortality Journal of Clinical Endocrinology and Metabolism. 99: 2128-2137. PMID 24606092 DOI: 10.1210/jc.2013-4018  0.36
2014 Bhattacharya S, Granger CB, Craig D, Haynes C, Bain J, Stevens RD, Hauser ER, Newgard CB, Kraus WE, Newby LK, Shah SH. Validation of the association between a branched chain amino acid metabolite profile and extremes of coronary artery disease in patients referred for cardiac catheterization. Atherosclerosis. 232: 191-6. PMID 24401236 DOI: 10.1016/j.atherosclerosis.2013.10.036  0.36
2014 Thalacker-Mercer AE, Ingram KH, Guo F, Ilkayeva O, Newgard CB, Garvey WT. BMI, RQ, diabetes, and sex affect the relationships between amino acids and clamp measures of insulin action in humans. Diabetes. 63: 791-800. PMID 24130332 DOI: 10.2337/db13-0396  0.36
2014 Scholtens DM, Muehlbauer MJ, Daya NR, Stevens RD, Dyer AR, Lowe LP, Metzger BE, Newgard CB, Bain JR, Lowe WL. Metabolomics reveals broad-scale metabolic perturbations in hyperglycemic mothers during pregnancy. Diabetes Care. 37: 158-66. PMID 23990511 DOI: 10.2337/dc13-0989  0.36
2014 Sinha RA, Farah BL, Singh BK, Siddique MM, Li Y, Wu Y, Ilkayeva OR, Gooding J, Ching J, Zhou J, Martinez L, Xie S, Bay BH, Summers SA, Newgard CB, et al. Caffeine stimulates hepatic lipid metabolism by the autophagy-lysosomal pathway in mice. Hepatology (Baltimore, Md.). 59: 1366-80. PMID 23929677 DOI: 10.1002/hep.26667  0.36
2014 Khoo CM, Muehlbauer MJ, Stevens RD, Pamuklar Z, Chen J, Newgard CB, Torquati A. Postprandial metabolite profiles reveal differential nutrient handling after bariatric surgery compared with matched caloric restriction. Annals of Surgery. 259: 687-93. PMID 23787216 DOI: 10.1097/SLA.0b013e318296633f  0.36
2013 Lamonte G, Tang X, Chen JL, Wu J, Ding CK, Keenan MM, Sangokoya C, Kung HN, Ilkayeva O, Boros LG, Newgard CB, Chi JT. Acidosis induces reprogramming of cellular metabolism to mitigate oxidative stress. Cancer & Metabolism. 1: 23. PMID 24359630 DOI: 10.1186/2049-3002-1-23  0.36
2013 Rardin MJ, He W, Nishida Y, Newman JC, Carrico C, Danielson SR, Guo A, Gut P, Sahu AK, Li B, Uppala R, Fitch M, Riiff T, Zhu L, Zhou J, ... ... Newgard CB, et al. SIRT5 regulates the mitochondrial lysine succinylome and metabolic networks. Cell Metabolism. 18: 920-33. PMID 24315375 DOI: 10.1016/j.cmet.2013.11.013  0.36
2013 Patel MJ, Batch BC, Svetkey LP, Bain JR, Turer CB, Haynes C, Muehlbauer MJ, Stevens RD, Newgard CB, Shah SH. Race and sex differences in small-molecule metabolites and metabolic hormones in overweight and obese adults. Omics : a Journal of Integrative Biology. 17: 627-35. PMID 24117402 DOI: 10.1089/omi.2013.0031  0.36
2013 Peek CB, Affinati AH, Ramsey KM, Kuo HY, Yu W, Sena LA, Ilkayeva O, Marcheva B, Kobayashi Y, Omura C, Levine DC, Bacsik DJ, Gius D, Newgard CB, Goetzman E, et al. Circadian clock NAD+ cycle drives mitochondrial oxidative metabolism in mice. Science (New York, N.Y.). 342: 1243417. PMID 24051248 DOI: 10.1126/science.1243417  0.36
2013 Ridaura VK, Faith JJ, Rey FE, Cheng J, Duncan AE, Kau AL, Griffin NW, Lombard V, Henrissat B, Bain JR, Muehlbauer MJ, Ilkayeva O, Semenkovich CF, Funai K, Hayashi DK, ... ... Newgard CB, et al. Gut microbiota from twins discordant for obesity modulate metabolism in mice. Science (New York, N.Y.). 341: 1241214. PMID 24009397 DOI: 10.1126/science.1241214  0.36
2013 Hayes HL, Moss LG, Schisler JC, Haldeman JM, Zhang Z, Rosenberg PB, Newgard CB, Hohmeier HE. Pdx-1 activates islet α- and β-cell proliferation via a mechanism regulated by transient receptor potential cation channels 3 and 6 and extracellular signal-regulated kinases 1 and 2. Molecular and Cellular Biology. 33: 4017-29. PMID 23938296 DOI: 10.1128/MCB.00469-13  0.36
2013 Jing E, O'Neill BT, Rardin MJ, Kleinridders A, Ilkeyeva OR, Ussar S, Bain JR, Lee KY, Verdin EM, Newgard CB, Gibson BW, Kahn CR. Sirt3 regulates metabolic flexibility of skeletal muscle through reversible enzymatic deacetylation. Diabetes. 62: 3404-17. PMID 23835326 DOI: 10.2337/db12-1650  0.36
2013 Jensen MV, Haldeman JM, Zhang H, Lu D, Huising MO, Vale WW, Hohmeier HE, Rosenberg P, Newgard CB. Control of voltage-gated potassium channel Kv2.2 expression by pyruvate-isocitrate cycling regulates glucose-stimulated insulin secretion. The Journal of Biological Chemistry. 288: 23128-40. PMID 23788641 DOI: 10.1074/jbc.M113.491654  0.36
2013 Gregory JF, Park Y, Lamers Y, Bandyopadhyay N, Chi YY, Lee K, Kim S, da Silva V, Hove N, Ranka S, Kahveci T, Muller KE, Stevens RD, Newgard CB, Stacpoole PW, et al. Metabolomic analysis reveals extended metabolic consequences of marginal vitamin B-6 deficiency in healthy human subjects. Plos One. 8: e63544. PMID 23776431 DOI: 10.1371/journal.pone.0063544  0.36
2013 Klett EL, Chen S, Edin ML, Li LO, Ilkayeva O, Zeldin DC, Newgard CB, Coleman RA. Diminished acyl-CoA synthetase isoform 4 activity in INS 832/13 cells reduces cellular epoxyeicosatrienoic acid levels and results in impaired glucose-stimulated insulin secretion. The Journal of Biological Chemistry. 288: 21618-29. PMID 23766516 DOI: 10.1074/jbc.M113.481077  0.36
2013 Kurland IJ, Accili D, Burant C, Fischer SM, Kahn BB, Newgard CB, Ramagiri S, Ronnett GV, Ryals JA, Sanders M, Shambaugh J, Shockcor J, Gross SS. Application of combined omics platforms to accelerate biomedical discovery in diabesity. Annals of the New York Academy of Sciences. 1287: 1-16. PMID 23659636 DOI: 10.1111/nyas.12116  0.36
2013 Magkos F, Bradley D, Schweitzer GG, Finck BN, Eagon JC, Ilkayeva O, Newgard CB, Klein S. Effect of Roux-en-Y gastric bypass and laparoscopic adjustable gastric banding on branched-chain amino acid metabolism. Diabetes. 62: 2757-61. PMID 23610059 DOI: 10.2337/db13-0185  0.36
2013 Johnson ES, Lindblom KR, Robeson A, Stevens RD, Ilkayeva OR, Newgard CB, Kornbluth S, Andersen JL. Metabolomic profiling reveals a role for caspase-2 in lipoapoptosis. The Journal of Biological Chemistry. 288: 14463-75. PMID 23553630 DOI: 10.1074/jbc.M112.437210  0.36
2013 Newgard CB, Sharpless NE. Coming of age: molecular drivers of aging and therapeutic opportunities. The Journal of Clinical Investigation. 123: 946-50. PMID 23454756 DOI: 10.1172/JCI68833  0.36
2013 Batch BC, Shah SH, Newgard CB, Turer CB, Haynes C, Bain JR, Muehlbauer M, Patel MJ, Stevens RD, Appel LJ, Newby LK, Svetkey LP. Branched chain amino acids are novel biomarkers for discrimination of metabolic wellness. Metabolism: Clinical and Experimental. 62: 961-9. PMID 23375209 DOI: 10.1016/j.metabol.2013.01.007  0.36
2013 York B, Sagen JV, Tsimelzon A, Louet JF, Chopra AR, Reineke EL, Zhou S, Stevens RD, Wenner BR, Ilkayeva O, Bain JR, Xu J, Hilsenbeck SG, Newgard CB, O'Malley BW. Research resource: tissue- and pathway-specific metabolomic profiles of the steroid receptor coactivator (SRC) family. Molecular Endocrinology (Baltimore, Md.). 27: 366-80. PMID 23315938 DOI: 10.1210/me.2012-1324  0.36
2013 Coppola A, Wenner BR, Ilkayeva O, Stevens RD, Maggioni M, Slotkin TA, Levin ED, Newgard CB. Branched-chain amino acids alter neurobehavioral function in rats. American Journal of Physiology. Endocrinology and Metabolism. 304: E405-13. PMID 23249694 DOI: 10.1152/ajpendo.00373.2012  0.36
2013 Shimazu T, Hirschey MD, Newman J, He W, Shirakawa K, Le Moan N, Grueter CA, Lim H, Saunders LR, Stevens RD, Newgard CB, Farese RV, de Cabo R, Ulrich S, Akassoglou K, et al. Suppression of oxidative stress by β-hydroxybutyrate, an endogenous histone deacetylase inhibitor. Science (New York, N.Y.). 339: 211-4. PMID 23223453 DOI: 10.1126/science.1227166  0.36
2013 Li XN, Herrington J, Petrov A, Ge L, Eiermann G, Xiong Y, Jensen MV, Hohmeier HE, Newgard CB, Garcia ML, Wagner M, Zhang BB, Thornberry NA, Howard AD, Kaczorowski GJ, et al. The role of voltage-gated potassium channels Kv2.1 and Kv2.2 in the regulation of insulin and somatostatin release from pancreatic islets. The Journal of Pharmacology and Experimental Therapeutics. 344: 407-16. PMID 23161216 DOI: 10.1124/jpet.112.199083  0.36
2013 Patel SG, Hsu JW, Jahoor F, Coraza I, Bain JR, Stevens RD, Iyer D, Nalini R, Ozer K, Hampe CS, Newgard CB, Balasubramanyam A. Pathogenesis of A⁻β⁺ ketosis-prone diabetes. Diabetes. 62: 912-22. PMID 23160531 DOI: 10.2337/db12-0624  0.36
2012 Thompson DK, Sloane R, Bain JR, Stevens RD, Newgard CB, Pieper CF, Kraus VB. Daily Variation of Serum Acylcarnitines and Amino Acids. Metabolomics : Official Journal of the Metabolomic Society. 8: 556-565. PMID 25067934 DOI: 10.1007/s11306-011-0345-9  0.36
2012 Reineke EL, York B, Stashi E, Chen X, Tsimelzon A, Xu J, Newgard CB, Taffet GE, Taegtmeyer H, Entman ML, O'Malley BW. SRC-2 coactivator deficiency decreases functional reserve in response to pressure overload of mouse heart. Plos One. 7: e53395. PMID 23300926 DOI: 10.1371/journal.pone.0053395  0.36
2012 Vernochet C, Mourier A, Bezy O, Macotela Y, Boucher J, Rardin MJ, An D, Lee KY, Ilkayeva OR, Zingaretti CM, Emanuelli B, Smyth G, Cinti S, Newgard CB, Gibson BW, et al. Adipose-specific deletion of TFAM increases mitochondrial oxidation and protects mice against obesity and insulin resistance. Cell Metabolism. 16: 765-76. PMID 23168219 DOI: 10.1016/j.cmet.2012.10.016  0.36
2012 Chao LC, Wroblewski K, Ilkayeva OR, Stevens RD, Bain J, Meyer GA, Schenk S, Martinez L, Vergnes L, Narkar VA, Drew BG, Hong C, Boyadjian R, Hevener AL, Evans RM, ... ... Newgard CB, et al. Skeletal muscle Nur77 expression enhances oxidative metabolism and substrate utilization. Journal of Lipid Research. 53: 2610-9. PMID 23028113 DOI: 10.1194/jlr.M029355  0.36
2012 Zhao M, Lamers Y, Ralat MA, Coats BS, Chi YY, Muller KE, Bain JR, Shankar MN, Newgard CB, Stacpoole PW, Gregory JF. Marginal vitamin B-6 deficiency decreases plasma (n-3) and (n-6) PUFA concentrations in healthy men and women. The Journal of Nutrition. 142: 1791-7. PMID 22955512 DOI: 10.3945/jn.112.163246  0.36
2012 Shah SH, Kraus WE, Newgard CB. Metabolomic profiling for the identification of novel biomarkers and mechanisms related to common cardiovascular diseases: form and function. Circulation. 126: 1110-20. PMID 22927473 DOI: 10.1161/CIRCULATIONAHA.111.060368  0.36
2012 Ku BJ, Kim TH, Lee JH, Buras ED, White LD, Stevens RD, Ilkayeva OR, Bain JR, Newgard CB, DeMayo FJ, Jeong JW. Mig-6 plays a critical role in the regulation of cholesterol homeostasis and bile acid synthesis. Plos One. 7: e42915. PMID 22912762 DOI: 10.1371/journal.pone.0042915  0.36
2012 Stephens SB, Schisler JC, Hohmeier HE, An J, Sun AY, Pitt GS, Newgard CB. A VGF-derived peptide attenuates development of type 2 diabetes via enhancement of islet β-cell survival and function. Cell Metabolism. 16: 33-43. PMID 22768837 DOI: 10.1016/j.cmet.2012.05.011  0.36
2012 Kim DH, Sartor MA, Bain JR, Sandoval D, Stevens RD, Medvedovic M, Newgard CB, Woods SC, Seeley RJ. Rapid and weight-independent improvement of glucose tolerance induced by a peptide designed to elicit apoptosis in adipose tissue endothelium. Diabetes. 61: 2299-310. PMID 22733798 DOI: 10.2337/db11-1579  0.36
2012 Gaudet MM, Falk RT, Stevens RD, Gunter MJ, Bain JR, Pfeiffer RM, Potischman N, Lissowska J, Peplonska B, Brinton LA, Garcia-Closas M, Newgard CB, Sherman ME. Analysis of serum metabolic profiles in women with endometrial cancer and controls in a population-based case-control study. The Journal of Clinical Endocrinology and Metabolism. 97: 3216-23. PMID 22730518 DOI: 10.1210/jc.2012-1490  0.36
2012 Sampey BP, Freemerman AJ, Zhang J, Kuan PF, Galanko JA, O'Connell TM, Ilkayeva OR, Muehlbauer MJ, Stevens RD, Newgard CB, Brauer HA, Troester MA, Makowski L. Metabolomic profiling reveals mitochondrial-derived lipid biomarkers that drive obesity-associated inflammation. Plos One. 7: e38812. PMID 22701716 DOI: 10.1371/journal.pone.0038812  0.36
2012 Sinha RA, You SH, Zhou J, Siddique MM, Bay BH, Zhu X, Privalsky ML, Cheng SY, Stevens RD, Summers SA, Newgard CB, Lazar MA, Yen PM. Thyroid hormone stimulates hepatic lipid catabolism via activation of autophagy. The Journal of Clinical Investigation. 122: 2428-38. PMID 22684107 DOI: 10.1172/JCI60580  0.36
2012 Shah SH, Sun JL, Stevens RD, Bain JR, Muehlbauer MJ, Pieper KS, Haynes C, Hauser ER, Kraus WE, Granger CB, Newgard CB, Califf RM, Newby LK. Baseline metabolomic profiles predict cardiovascular events in patients at risk for coronary artery disease. American Heart Journal. 163: 844-850.e1. PMID 22607863 DOI: 10.1016/j.ahj.2012.02.005  0.36
2012 York B, Reineke EL, Sagen JV, Nikolai BC, Zhou S, Louet JF, Chopra AR, Chen X, Reed G, Noebels J, Adesina AM, Yu H, Wong LJ, Tsimelzon A, Hilsenbeck S, ... ... Newgard CB, et al. Ablation of steroid receptor coactivator-3 resembles the human CACT metabolic myopathy. Cell Metabolism. 15: 752-63. PMID 22560224 DOI: 10.1016/j.cmet.2012.03.020  0.36
2012 Farese RV, Zechner R, Newgard CB, Walther TC. The problem of establishing relationships between hepatic steatosis and hepatic insulin resistance Cell Metabolism. 15: 570-573. PMID 22560209 DOI: 10.1016/j.cmet.2012.03.004  0.36
2012 Huffman KM, Redman LM, Landerman LR, Pieper CF, Stevens RD, Muehlbauer MJ, Wenner BR, Bain JR, Kraus VB, Newgard CB, Ravussin E, Kraus WE. Caloric restriction alters the metabolic response to a mixed-meal: results from a randomized, controlled trial. Plos One. 7: e28190. PMID 22523532 DOI: 10.1371/journal.pone.0028190  0.36
2012 Kimple ME, Moss JB, Brar HK, Rosa TC, Truchan NA, Pasker RL, Newgard CB, Casey PJ. Deletion of GαZ protein protects against diet-induced glucose intolerance via expansion of β-cell mass. The Journal of Biological Chemistry. 287: 20344-55. PMID 22457354 DOI: 10.1074/jbc.M112.359745  0.36
2012 Shah AA, Craig DM, Sebek JK, Haynes C, Stevens RC, Muehlbauer MJ, Granger CB, Hauser ER, Newby LK, Newgard CB, Kraus WE, Hughes GC, Shah SH. Metabolic profiles predict adverse events after coronary artery bypass grafting. The Journal of Thoracic and Cardiovascular Surgery. 143: 873-8. PMID 22306227 DOI: 10.1016/j.jtcvs.2011.09.070  0.36
2012 Anderson KA, Lin F, Ribar TJ, Stevens RD, Muehlbauer MJ, Newgard CB, Means AR. Deletion of CaMKK2 from the liver lowers blood glucose and improves whole-body glucose tolerance in the mouse. Molecular Endocrinology (Baltimore, Md.). 26: 281-91. PMID 22240810 DOI: 10.1210/me.2011-1299  0.36
2011 McNulty NP, Yatsunenko T, Hsiao A, Faith JJ, Muegge BD, Goodman AL, Henrissat B, Oozeer R, Cools-Portier S, Gobert G, Chervaux C, Knights D, Lozupone CA, Knight R, Duncan AE, ... ... Newgard CB, et al. The impact of a consortium of fermented milk strains on the gut microbiome of gnotobiotic mice and monozygotic twins. Science Translational Medicine. 3: 106ra106. PMID 22030749 DOI: 10.1126/scitranslmed.3002701  0.36
2011 Brunner MP, Shah SH, Craig DM, Stevens RD, Muehlbauer MJ, Bain JR, Newgard CB, Kraus WE, Granger CB, Sketch MH, Newby LK. Effect of heparin administration on metabolomic profiles in samples obtained during cardiac catheterization. Circulation. Cardiovascular Genetics. 4: 695-700. PMID 22010138 DOI: 10.1161/CIRCGENETICS.111.960575  0.36
2011 Hirschey MD, Shimazu T, Jing E, Grueter CA, Collins AM, Aouizerat B, Stančáková A, Goetzman E, Lam MM, Schwer B, Stevens RD, Muehlbauer MJ, Kakar S, Bass NM, Kuusisto J, ... ... Newgard CB, et al. SIRT3 deficiency and mitochondrial protein hyperacetylation accelerate the development of the metabolic syndrome. Molecular Cell. 44: 177-90. PMID 21856199 DOI: 10.1016/j.molcel.2011.07.019  0.36
2011 Shah SH, Svetkey LP, Newgard CB. Branching out for detection of type 2 diabetes. Cell Metabolism. 13: 491-2. PMID 21531330 DOI: 10.1016/j.cmet.2011.04.003  0.36
2011 Laferrère B, Reilly D, Arias S, Swerdlow N, Gorroochurn P, Bawa B, Bose M, Teixeira J, Stevens RD, Wenner BR, Bain JR, Muehlbauer MJ, Haqq A, Lien L, Shah SH, ... ... Newgard CB, et al. Differential metabolic impact of gastric bypass surgery versus dietary intervention in obese diabetic subjects despite identical weight loss. Science Translational Medicine. 3: 80re2. PMID 21525399 DOI: 10.1126/scitranslmed.3002043  0.36
2011 Lum H, Sloane R, Huffman KM, Kraus VB, Thompson DK, Kraus WE, Bain JR, Stevens R, Pieper CF, Taylor GA, Newgard CB, Cohen HJ, Morey MC. Plasma acylcarnitines are associated with physical performance in elderly men. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. 66: 548-53. PMID 21367961 DOI: 10.1093/gerona/glr006  0.36
2011 Sampey BP, Vanhoose AM, Winfield HM, Freemerman AJ, Muehlbauer MJ, Fueger PT, Newgard CB, Makowski L. Cafeteria diet is a robust model of human metabolic syndrome with liver and adipose inflammation: comparison to high-fat diet. Obesity (Silver Spring, Md.). 19: 1109-17. PMID 21331068 DOI: 10.1038/oby.2011.18  0.36
2011 Horn SR, Thomenius MJ, Johnson ES, Freel CD, Wu JQ, Coloff JL, Yang CS, Tang W, An J, Ilkayeva OR, Rathmell JC, Newgard CB, Kornbluth S. Regulation of mitochondrial morphology by APC/CCdh1-mediated control of Drp1 stability. Molecular Biology of the Cell. 22: 1207-16. PMID 21325626 DOI: 10.1091/mbc.E10-07-0567  0.36
2011 Redman LM, Huffman KM, Landerman LR, Pieper CF, Bain JR, Muehlbauer MJ, Stevens RD, Wenner BR, Kraus VB, Newgard CB, Kraus WE, Ravussin E. Effect of caloric restriction with and without exercise on metabolic intermediates in nonobese men and women. The Journal of Clinical Endocrinology and Metabolism. 96: E312-21. PMID 21123443 DOI: 10.1210/jc.2010-1971  0.36
2011 Huffman KM, Slentz CA, Bateman LA, Thompson D, Muehlbauer MJ, Bain JR, Stevens RD, Wenner BR, Kraus VB, Newgard CB, Kraus WE. Exercise-induced changes in metabolic intermediates, hormones, and inflammatory markers associated with improvements in insulin sensitivity. Diabetes Care. 34: 174-6. PMID 20921216 DOI: 10.2337/dc10-0709  0.36
2010 Louet JF, Chopra AR, Sagen JV, An J, York B, Tannour-Louet M, Saha PK, Stevens RD, Wenner BR, Ilkayeva OR, Bain JR, Zhou S, DeMayo F, Xu J, Newgard CB, et al. The coactivator SRC-1 is an essential coordinator of hepatic glucose production. Cell Metabolism. 12: 606-18. PMID 21109193 DOI: 10.1016/j.cmet.2010.11.009  0.36
2010 Turer AT, Malloy CR, Newgard CB, Podgoreanu MV. Energetics and metabolism in the failing heart: important but poorly understood. Current Opinion in Clinical Nutrition and Metabolic Care. 13: 458-65. PMID 20453645 DOI: 10.1097/MCO.0b013e32833a55a5  0.36
2010 Odegaard ML, Joseph JW, Jensen MV, Lu D, Ilkayeva O, Ronnebaum SM, Becker TC, Newgard CB. The mitochondrial 2-oxoglutarate carrier is part of a metabolic pathway that mediates glucose- and glutamine-stimulated insulin secretion. The Journal of Biological Chemistry. 285: 16530-7. PMID 20356834 DOI: 10.1074/jbc.M109.092593  0.36
2008 Ronnebaum SM, Jensen MV, Hohmeier HE, Burgess SC, Zhou YP, Qian S, MacNeil D, Howard A, Thornberry N, Ilkayeva O, Lu D, Sherry AD, Newgard CB. Silencing of cytosolic or mitochondrial isoforms of malic enzyme has no effect on glucose-stimulated insulin secretion from rodent islets. The Journal of Biological Chemistry. 283: 28909-17. PMID 18755687 DOI: 10.1074/jbc.M804665200  0.36
2008 Jensen MV, Joseph JW, Ronnebaum SM, Burgess SC, Sherry AD, Newgard CB. Metabolic cycling in control of glucose-stimulated insulin secretion. American Journal of Physiology. Endocrinology and Metabolism. 295: E1287-97. PMID 18728221 DOI: 10.1152/ajpendo.90604.2008  0.36
2008 Ronnebaum SM, Joseph JW, Ilkayeva O, Burgess SC, Lu D, Becker TC, Sherry AD, Newgard CB. Chronic suppression of acetyl-CoA carboxylase 1 in beta-cells impairs insulin secretion via inhibition of glucose rather than lipid metabolism. The Journal of Biological Chemistry. 283: 14248-56. PMID 18381287 DOI: 10.1074/jbc.M800119200  0.36
2008 Ferrara CT, Wang P, Neto EC, Stevens RD, Bain JR, Wenner BR, Ilkayeva OR, Keller MP, Blasiole DA, Kendziorski C, Yandell BS, Newgard CB, Attie AD. Genetic networks of liver metabolism revealed by integration of metabolic and transcriptional profiling. Plos Genetics. 4: e1000034. PMID 18369453 DOI: 10.1371/journal.pgen.1000034  0.32
2007 Joseph JW, Odegaard ML, Ronnebaum SM, Burgess SC, Muehlbauer J, Sherry AD, Newgard CB. Normal flux through ATP-citrate lyase or fatty acid synthase is not required for glucose-stimulated insulin secretion. The Journal of Biological Chemistry. 282: 31592-600. PMID 17823126 DOI: 10.1074/jbc.M706080200  0.36
2006 Ronnebaum SM, Ilkayeva O, Burgess SC, Joseph JW, Lu D, Stevens RD, Becker TC, Sherry AD, Newgard CB, Jensen MV. A pyruvate cycling pathway involving cytosolic NADP-dependent isocitrate dehydrogenase regulates glucose-stimulated insulin secretion. The Journal of Biological Chemistry. 281: 30593-602. PMID 16912049 DOI: 10.1074/jbc.M511908200  0.36
2006 Jensen MV, Joseph JW, Ilkayeva O, Burgess S, Lu D, Ronnebaum SM, Odegaard M, Becker TC, Sherry AD, Newgard CB. Compensatory responses to pyruvate carboxylase suppression in islet beta-cells. Preservation of glucose-stimulated insulin secretion. The Journal of Biological Chemistry. 281: 22342-51. PMID 16740637 DOI: 10.1074/jbc.M604350200  0.36
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