Klaus H. Kaestner - Publications

Affiliations: 
University of Pennsylvania, Philadelphia, PA, United States 
Area:
Molecular Biology, Cell Biology

141 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Zhu L, Dattaroy D, Pham J, Wang L, Barella LF, Cui Y, Wilkins KJ, Roth BL, Hochgeschwender U, Matschinsky FM, Kaestner KH, Doliba NM, Wess J. Intra-islet glucagon signaling is critical for maintaining glucose homeostasis. Jci Insight. 5. PMID 31012868 DOI: 10.1172/jci.insight.127994  0.32
2019 Zheng D, McLaughlin SA, Kaestner KH, Li Z. Genetic ablation of mammary ducts through foxa1 prevents breast cancer occurrence. American Journal of Cancer Research. 9: 424-428. PMID 30906639  0.36
2019 Wang YJ, Traum D, Schug J, Gao L, Liu C, Atkinson MA, Powers AC, Feldman MD, Naji A, Chang KM, Kaestner KH. Multiplexed In Situ Imaging Mass Cytometry Analysis of the Human Endocrine Pancreas and Immune System in Type 1 Diabetes. Cell Metabolism. PMID 30713110 DOI: 10.1016/j.cmet.2019.01.003  0.52
2018 Kameswaran V, Golson M, Rodriguez MR, Ou K, Wang YJ, Zhang J, Pasquali L, Kaestner KH. The Dysregulation of the - Locus in Islets From Type 2 Diabetics is Mimicked by Targeted Epimutation of its Promoter with TALE-DNMT Constructs. Diabetes. PMID 30084829 DOI: 10.2337/db17-0682  0.36
2018 Ou K, Zhang J, Jiao Y, Wang ZV, Scherer P, Kaestner KH. Overexpression of ST5, an activator of Ras, has no effect on β-cell proliferation in adult mice. Molecular Metabolism. PMID 29650351 DOI: 10.1016/j.molmet.2018.03.009  0.56
2018 Gazala SA, Horwitz E, Ben-Haroush Schyr R, Bardugo A, Israeli H, Hija A, Schug J, Shin S, Dor Y, Kaestner KH, Ben-Zvi D. Sleeve Gastrectomy Improves Glycemia Independent of Weight Loss by Restoring Hepatic Insulin Sensitivity. Diabetes. PMID 29475831 DOI: 10.2337/db17-1028  0.52
2018 Serr I, Scherm MG, Zahm AM, Schug J, Flynn VK, Hippich M, Kälin S, Becker M, Achenbach P, Nikolaev A, Gerlach K, Liebsch N, Loretz B, Lehr CM, Kirchner B, ... ... Kaestner KH, et al. A miRNA181a/NFAT5 axis links impaired T cell tolerance induction with autoimmune type 1 diabetes. Science Translational Medicine. 10. PMID 29298866 DOI: 10.1126/scitranslmed.aag1782  0.52
2017 Kim JH, Hedrick S, Tsai WW, Wiater E, Le Lay J, Kaestner KH, Leblanc M, Loar A, Montminy M. CREB coactivators CRTC2 and CRTC3 modulate bone marrow hematopoiesis. Proceedings of the National Academy of Sciences of the United States of America. PMID 29078378 DOI: 10.1073/pnas.1712616114  0.56
2017 Golson ML, Kaestner KH. Epigenetics in formation, function, and failure of the endocrine pancreas. Molecular Metabolism. 6: 1066-1076. PMID 28951829 DOI: 10.1016/j.molmet.2017.05.015  0.8
2017 Galivo F, Benedetti E, Wang Y, Pelz C, Schug J, Kaestner KH, Grompe M. Reprogramming human gallbladder cells into insulin-producing β-like cells. Plos One. 12: e0181812. PMID 28813430 DOI: 10.1371/journal.pone.0181812  0.52
2017 Xu M, Horrell J, Snitow M, Cui J, Gochnauer H, Syrett CM, Kallish S, Seykora JT, Liu F, Gaillard D, Katz JP, Kaestner KH, Levin B, Mansfield C, Douglas JE, et al. WNT10A mutation causes ectodermal dysplasia by impairing progenitor cell proliferation and KLF4-mediated differentiation. Nature Communications. 8: 15397. PMID 28589954 DOI: 10.1038/ncomms15397  0.52
2017 Li C, Ackermann AM, Boodhansingh KE, Bhatti TR, Liu C, Schug J, Doliba N, Han B, Cosgrove KE, Banerjee I, Matschinsky FM, Nissim I, Kaestner KH, Naji A, Adzick NS, et al. Functional and Metabolomic Consequences of ATP-dependent Potassium Channel Inactivation in Human Islets. Diabetes. PMID 28442472 DOI: 10.2337/db17-0029  0.52
2017 Ackermann AM, Zhang J, Heller A, Briker A, Kaestner KH. High-fidelity Glucagon-CreER mouse line generated by CRISPR-Cas9 assisted gene targeting. Molecular Metabolism. 6: 236-244. PMID 28271030 DOI: 10.1016/j.molmet.2017.01.003  0.36
2017 Zhang J, Kaestner KH. Epigenetic Analysis of Endocrine Cell Subtypes from Human Pancreatic Islets. Methods in Molecular Biology (Clifton, N.J.). 1507: 95-111. PMID 27832535 DOI: 10.1007/978-1-4939-6518-2_8  0.36
2016 Golson ML, Kaestner KH. Fox transcription factors: from development to disease. Development (Cambridge, England). 143: 4558-4570. PMID 27965437 DOI: 10.1242/dev.112672  0.8
2016 Ediger BN, Lim HW, Juliana C, Groff DN, Williams LT, Dominguez G, Liu JH, Taylor BL, Walp ER, Kameswaran V, Yang J, Liu C, Hunter CS, Kaestner KH, Naji A, et al. LIM domain-binding 1 maintains the terminally differentiated state of pancreatic β cells. The Journal of Clinical Investigation. PMID 27941246 DOI: 10.1172/JCI88016  0.32
2016 Swisa A, Avrahami D, Eden N, Zhang J, Feleke E, Dahan T, Cohen-Tayar Y, Stolovich-Rain M, Kaestner KH, Glaser B, Ashery-Padan R, Dor Y. PAX6 maintains β cell identity by repressing genes of alternative islet cell types. The Journal of Clinical Investigation. PMID 27941241 DOI: 10.1172/JCI88015  0.36
2016 Bernstein D, Golson ML, Kaestner KH. Epigenetic control of β-cell function and failure. Diabetes Research and Clinical Practice. 123: 24-36. PMID 27918975 DOI: 10.1016/j.diabres.2016.11.009  0.8
2016 Wang YJ, Golson ML, Schug J, Traum D, Liu C, Vivek K, Dorrell C, Naji A, Powers AC, Chang KM, Grompe M, Kaestner KH. Single-Cell Mass Cytometry Analysis of the Human Endocrine Pancreas. Cell Metabolism. 24: 616-626. PMID 27732837 DOI: 10.1016/j.cmet.2016.09.007  0.8
2016 Dorrell C, Schug J, Canaday PS, Russ HA, Tarlow BD, Grompe MT, Horton T, Hebrok M, Streeter PR, Kaestner KH, Grompe M. Human islets contain four distinct subtypes of β cells. Nature Communications. 7: 11756. PMID 27399229 DOI: 10.1038/ncomms11756  0.52
2016 Dapprich J, Ferriola D, Mackiewicz K, Clark PM, Rappaport E, D'Arcy M, Sasson A, Gai X, Schug J, Kaestner KH, Monos D. The next generation of target capture technologies - large DNA fragment enrichment and sequencing determines regional genomic variation of high complexity. Bmc Genomics. 17: 486. PMID 27393338 DOI: 10.1186/s12864-016-2836-6  0.52
2016 Wang YJ, Schug J, Won KJ, Liu C, Naji A, Avrahami D, Golson ML, Kaestner KH. Single cell transcriptomics of the human endocrine pancreas. Diabetes. PMID 27364731 DOI: 10.2337/db16-0405  0.8
2016 Shin S, Wangensteen KJ, Teta-Bissett M, Wang YJ, Mosleh-Shirazi E, Buza EL, Greenbaum LE, Kaestner KH. Genetic Lineage Tracing Analysis of the Cell of Origin of Hepatotoxin-Induced Liver Tumors in Mice. Hepatology (Baltimore, Md.). PMID 27099001 DOI: 10.1002/hep.28602  0.52
2016 Ackermann AM, Wang Z, Schug J, Naji A, Kaestner KH. Integration of ATAC-seq and RNA-seq identifies human alpha cell and beta cell signature genes. Molecular Metabolism. 5: 233-44. PMID 26977395 DOI: 10.1016/j.molmet.2016.01.002  0.52
2016 Aoki R, Shoshkes-Carmel M, Gao N, Shin S, May CL, Golson ML, Zahm AM, Ray M, Wiser CL, Wright CV, Kaestner KH. Foxl1-expressing mesenchymal cells constitute the intestinal stem cell niche. Cellular and Molecular Gastroenterology and Hepatology. 2: 175-188. PMID 26949732 DOI: 10.1016/j.jcmgh.2015.12.004  0.52
2016 Liu Y, Zhao Y, Skerry B, Wang X, Colin-Cassin C, Radisky DC, Kaestner KH, Li Z. Foxa1 is essential for mammary duct formation. Genesis (New York, N.Y. : 2000). PMID 26919034 DOI: 10.1002/dvg.22929  0.36
2015 Ferreira MJ, McKenna LB, Zhang J, Reichert M, Bakir B, Buza EL, Furth EE, Bogue CW, Rustgi AK, Kaestner KH. Spontaneous Pancreatitis Caused by Tissue-Specific Gene Ablation of Hhex in Mice. Cellular and Molecular Gastroenterology and Hepatology. 1: 550-569. PMID 26740970  0.4
2015 Avrahami D, Li C, Zhang J, Schug J, Avrahami R, Rao S, Stadler MB, Burger L, Schübeler D, Glaser B, Kaestner KH. Aging-Dependent Demethylation of Regulatory Elements Correlates with Chromatin State and Improved β Cell Function. Cell Metabolism. PMID 26321660 DOI: 10.1016/j.cmet.2015.07.025  0.52
2015 Hernandez JB, Chang C, LeBlanc M, Grimm D, Le Lay J, Kaestner KH, Zheng Y, Montminy M. The CREB/CRTC2 pathway modulates autoimmune disease by promoting Th17 differentiation. Nature Communications. 6: 7216. PMID 26031354 DOI: 10.1038/ncomms8216  0.52
2015 Elliott EN, Sheaffer KL, Schug J, Stappenbeck TS, Kaestner KH. Dnmt1 is essential to maintain progenitors in the perinatal intestinal epithelium. Development (Cambridge, England). 142: 2163-72. PMID 26023099 DOI: 10.1242/dev.117341  0.52
2015 Wangensteen KJ, Zhang S, Greenbaum LE, Kaestner KH. A genetic screen reveals Foxa3 and TNFR1 as key regulators of liver repopulation. Genes & Development. 29: 904-9. PMID 25934503 DOI: 10.1101/gad.258855.115  0.52
2015 Reddy OL, Cates JM, Gellert LL, Crist HS, Yang Z, Yamashita H, Taylor JA, Smith JA, Chang SS, Cookson MS, You C, Barocas DA, Grabowska MM, Ye F, Wu XR, ... ... Kaestner KH, et al. Loss of FOXA1 Drives Sexually Dimorphic Changes in Urothelial Differentiation and Is an Independent Predictor of Poor Prognosis in Bladder Cancer. The American Journal of Pathology. 185: 1385-95. PMID 25907831 DOI: 10.1016/j.ajpath.2015.01.014  0.52
2015 Nishikawa T, Bell A, Brooks JM, Setoyama K, Melis M, Han B, Fukumitsu K, Handa K, Tian J, Kaestner KH, Vodovotz Y, Locker J, Soto-Gutierrez A, Fox IJ. Resetting the transcription factor network reverses terminal chronic hepatic failure. The Journal of Clinical Investigation. 125: 1533-44. PMID 25774505 DOI: 10.1172/JCI73137  0.52
2015 Briand LA, Lee BG, Lelay J, Kaestner KH, Blendy JA. Serine 133 phosphorylation is not required for hippocampal CREB-mediated transcription and behavior. Learning & Memory (Cold Spring Harbor, N.Y.). 22: 109-15. PMID 25593297 DOI: 10.1101/lm.037044.114  0.52
2015 Jiao Y, Ye DZ, Li Z, Teta-Bissett M, Peng Y, Taub R, Greenbaum LE, Kaestner KH. Protein tyrosine phosphatase of liver regeneration-1 is required for normal timing of cell cycle progression during liver regeneration. American Journal of Physiology. Gastrointestinal and Liver Physiology. 308: G85-91. PMID 25377314 DOI: 10.1152/ajpgi.00084.2014  0.56
2015 Shin S, Upadhyay N, Greenbaum LE, Kaestner KH. Ablation of Foxl1-Cre-labeled hepatic progenitor cells and their descendants impairs recovery of mice from liver injury. Gastroenterology. 148: 192-202.e3. PMID 25286440 DOI: 10.1053/j.gastro.2014.09.039  0.52
2015 Terry NA, Lee RA, Walp ER, Kaestner KH, Lee May C. Dysgenesis of enteroendocrine cells in Aristaless-Related Homeobox polyalanine expansion mutations. Journal of Pediatric Gastroenterology and Nutrition. 60: 192-9. PMID 25171319 DOI: 10.1097/MPG.0000000000000542  0.52
2014 Johnson ME, Zhao J, Schug J, Deliard S, Xia Q, Guy VC, Sainz J, Kaestner KH, Wells AD, Grant SF. Two novel type 2 diabetes loci revealed through integration of TCF7L2 DNA occupancy and SNP association data. Bmj Open Diabetes Research & Care. 2: e000052. PMID 25469308 DOI: 10.1136/bmjdrc-2014-000052  0.52
2014 Shin S, Le Lay J, Everett LJ, Gupta R, Rafiq K, Kaestner KH. CREB mediates the insulinotropic and anti-apoptotic effects of GLP-1 signaling in adult mouse β-cells. Molecular Metabolism. 3: 803-12. PMID 25379405 DOI: 10.1016/j.molmet.2014.08.001  0.52
2014 Terry NA, Walp ER, Lee RA, Kaestner KH, May CL. Impaired enteroendocrine development in intestinal-specific Islet1 mouse mutants causes impaired glucose homeostasis. American Journal of Physiology. Gastrointestinal and Liver Physiology. 307: G979-91. PMID 25214396 DOI: 10.1152/ajpgi.00390.2013  0.52
2014 Dorrell C, Tarlow B, Wang Y, Canaday PS, Haft A, Schug J, Streeter PR, Finegold MJ, Shenje LT, Kaestner KH, Grompe M. The organoid-initiating cells in mouse pancreas and liver are phenotypically and functionally similar. Stem Cell Research. 13: 275-83. PMID 25151611 DOI: 10.1016/j.scr.2014.07.006  0.52
2014 Choi I, Kim R, Lim HW, Kaestner KH, Won KJ. 5-hydroxymethylcytosine represses the activity of enhancers in embryonic stem cells: a new epigenetic signature for gene regulation. Bmc Genomics. 15: 670. PMID 25106691 DOI: 10.1186/1471-2164-15-670  0.52
2014 Patel K, Foretz M, Marion A, Campbell DG, Gourlay R, Boudaba N, Tournier E, Titchenell P, Peggie M, Deak M, Wan M, Kaestner KH, Göransson O, Viollet B, Gray NS, et al. The LKB1-salt-inducible kinase pathway functions as a key gluconeogenic suppressor in the liver. Nature Communications. 5: 4535. PMID 25088745 DOI: 10.1038/ncomms5535  0.52
2014 Golson ML, Maulis MF, Dunn JC, Poffenberger G, Schug J, Kaestner KH, Gannon MA. Activated FoxM1 attenuates streptozotocin-mediated β-cell death. Molecular Endocrinology (Baltimore, Md.). 28: 1435-47. PMID 25073103 DOI: 10.1210/me.2014-1024  0.8
2014 Ediger BN, Du A, Liu J, Hunter CS, Walp ER, Schug J, Kaestner KH, Stein R, Stoffers DA, May CL. Islet-1 Is essential for pancreatic β-cell function. Diabetes. 63: 4206-17. PMID 25028525 DOI: 10.2337/db14-0096  0.52
2014 Johnson ME, Schug J, Wells AD, Kaestner KH, Grant SF. Genome-wide analyses of ChIP-Seq derived FOXA2 DNA occupancy in liver points to genetic networks underpinning multiple complex traits. The Journal of Clinical Endocrinology and Metabolism. 99: E1580-5. PMID 24878043 DOI: 10.1210/jc.2013-4503  0.52
2014 DeGraff DJ, Grabowska MM, Case TC, Yu X, Herrick MK, Hayward WJ, Strand DW, Cates JM, Hayward SW, Gao N, Walter MA, Buttyan R, Yi Y, Kaestner KH, Matusik RJ. FOXA1 deletion in luminal epithelium causes prostatic hyperplasia and alteration of differentiated phenotype. Laboratory Investigation; a Journal of Technical Methods and Pathology. 94: 726-39. PMID 24840332 DOI: 10.1038/labinvest.2014.64  0.52
2014 Zhang J, McKenna LB, Bogue CW, Kaestner KH. The diabetes gene Hhex maintains δ-cell differentiation and islet function. Genes & Development. 28: 829-34. PMID 24736842 DOI: 10.1101/gad.235499.113  0.36
2014 Sheaffer KL, Kim R, Aoki R, Elliott EN, Schug J, Burger L, Schübeler D, Kaestner KH. DNA methylation is required for the control of stem cell differentiation in the small intestine Genes and Development. 28: 652-664. PMID 24637118 DOI: 10.1101/gad.230318.113  0.52
2014 Lee D, Le Lay J, Kaestner KH. The transcription factor CREB has no non-redundant functions in hepatic glucose metabolism in mice. Diabetologia. 57: 1242-8. PMID 24595858 DOI: 10.1007/s00125-014-3203-2  0.56
2014 Seth A, Ye J, Yu N, Guez F, Bedford DC, Neale GA, Cordi S, Brindle PK, Lemaigre FP, Kaestner KH, Sosa-Pineda B. Prox1 ablation in hepatic progenitors causes defective hepatocyte specification and increases biliary cell commitment. Development (Cambridge, England). 141: 538-47. PMID 24449835 DOI: 10.1242/dev.099481  0.52
2014 Shin S, Kaestner KH. The origin, biology, and therapeutic potential of facultative adult hepatic progenitor cells. Current Topics in Developmental Biology. 107: 269-92. PMID 24439810 DOI: 10.1016/B978-0-12-416022-4.00010-X  0.52
2014 Avrahami D, Li C, Yu M, Jiao Y, Zhang J, Naji A, Ziaie S, Glaser B, Kaestner KH. Targeting the cell cycle inhibitor p57Kip2 promotes adult human β cell replication. The Journal of Clinical Investigation. 124: 670-4. PMID 24430183 DOI: 10.1172/JCI69519  0.52
2014 Kameswaran V, Bramswig NC, McKenna LB, Penn M, Schug J, Hand NJ, Chen Y, Choi I, Vourekas A, Won KJ, Liu C, Vivek K, Naji A, Friedman JR, Kaestner KH. Epigenetic regulation of the DLK1-MEG3 microRNA cluster in human type 2 diabetic islets. Cell Metabolism. 19: 135-45. PMID 24374217 DOI: 10.1016/j.cmet.2013.11.016  0.52
2014 Jiao Y, Le Lay J, Yu M, Naji A, Kaestner KH. Elevated mouse hepatic betatrophin expression does not increase human β-cell replication in the transplant setting. Diabetes. 63: 1283-8. PMID 24353178 DOI: 10.2337/db13-1435  0.56
2013 Bochkis IM, Shin S, Kaestner KH. Bile acid-induced inflammatory signaling in mice lacking Foxa2 in the liver leads to activation of mTOR and age-onset obesity. Molecular Metabolism. 2: 447-56. PMID 24327960 DOI: 10.1016/j.molmet.2013.08.005  0.52
2013 Gundersen BB, Briand LA, Onksen JL, Lelay J, Kaestner KH, Blendy JA. Increased hippocampal neurogenesis and accelerated response to antidepressants in mice with specific deletion of CREB in the hippocampus: role of cAMP response-element modulator Ï„. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 13673-85. PMID 23966689 DOI: 10.1523/JNEUROSCI.1669-13.2013  0.52
2013 Deng Z, Glousker G, Molczan A, Fox AJ, Lamm N, Dheekollu J, Weizman OE, Schertzer M, Wang Z, Vladimirova O, Schug J, Aker M, Londoño-Vallejo A, Kaestner KH, Lieberman PM, et al. Inherited mutations in the helicase RTEL1 cause telomere dysfunction and Hoyeraal-Hreidarsson syndrome. Proceedings of the National Academy of Sciences of the United States of America. 110: E3408-16. PMID 23959892 DOI: 10.1073/pnas.1300600110  0.52
2013 Jiao Y, Rieck S, Le Lay J, Kaestner KH. CISH has no non-redundant functions in glucose homeostasis or beta cell proliferation during pregnancy in mice. Diabetologia. 56: 2435-45. PMID 23949579 DOI: 10.1007/s00125-013-3014-x  1
2013 Xu L, Panel V, Ma X, Du C, Hugendubler L, Gavrilova O, Liu A, McLaughlin T, Kaestner KH, Mueller E. The winged helix transcription factor Foxa3 regulates adipocyte differentiation and depot-selective fat tissue expansion. Molecular and Cellular Biology. 33: 3392-9. PMID 23798556 DOI: 10.1128/MCB.00244-13  0.52
2013 Everett LJ, Le Lay J, Lukovac S, Bernstein D, Steger DJ, Lazar MA, Kaestner KH. Integrative genomic analysis of CREB defines a critical role for transcription factor networks in mediating the fed/fasted switch in liver. Bmc Genomics. 14: 337. PMID 23682854 DOI: 10.1186/1471-2164-14-337  0.52
2013 Schug J, McKenna LB, Walton G, Hand N, Mukherjee S, Essuman K, Shi Z, Gao Y, Markley K, Nakagawa M, Kameswaran V, Vourekas A, Friedman JR, Kaestner KH, Greenbaum LE. Dynamic recruitment of microRNAs to their mRNA targets in the regenerating liver. Bmc Genomics. 14: 264. PMID 23597149 DOI: 10.1186/1471-2164-14-264  0.52
2013 Hickey RD, Galivo F, Schug J, Brehm MA, Haft A, Wang Y, Benedetti E, Gu G, Magnuson MA, Shultz LD, Lagasse E, Greiner DL, Kaestner KH, Grompe M. Generation of islet-like cells from mouse gall bladder by direct ex vivo reprogramming. Stem Cell Research. 11: 503-15. PMID 23562832 DOI: 10.1016/j.scr.2013.02.005  0.52
2013 Bramswig NC, Everett LJ, Schug J, Dorrell C, Liu C, Luo Y, Streeter PR, Naji A, Grompe M, Kaestner KH. Epigenomic plasticity enables human pancreatic α to β cell reprogramming. The Journal of Clinical Investigation. 123: 1275-84. PMID 23434589 DOI: 10.1172/JCI66514  0.52
2013 Schaffer AE, Taylor BL, Benthuysen JR, Liu J, Thorel F, Yuan W, Jiao Y, Kaestner KH, Herrera PL, Magnuson MA, May CL, Sander M. Nkx6.1 controls a gene regulatory network required for establishing and maintaining pancreatic Beta cell identity. Plos Genetics. 9: e1003274. PMID 23382704 DOI: 10.1371/journal.pgen.1003274  0.52
2013 Jean JC, George E, Kaestner KH, Brown LA, Spira A, Joyce-Brady M. Transcription factor Klf4, induced in the lung by oxygen at birth, regulates perinatal fibroblast and myofibroblast differentiation. Plos One. 8: e54806. PMID 23372771 DOI: 10.1371/journal.pone.0054806  0.52
2013 Xie R, Everett LJ, Lim HW, Patel NA, Schug J, Kroon E, Kelly OG, Wang A, D'Amour KA, Robins AJ, Won KJ, Kaestner KH, Sander M. Dynamic chromatin remodeling mediated by polycomb proteins orchestrates pancreatic differentiation of human embryonic stem cells. Cell Stem Cell. 12: 224-37. PMID 23318056 DOI: 10.1016/j.stem.2012.11.023  0.52
2013 Lamounier RN, Coimbra CN, White P, Costal FL, Oliveira LS, Giannella-Neto D, Kaestner KH, Corrêa-Giannella ML. Apoptosis rate and transcriptional response of pancreatic islets exposed to the PPAR gamma agonist Pioglitazone. Diabetology & Metabolic Syndrome. 5: 1. PMID 23298687 DOI: 10.1186/1758-5996-5-1  0.48
2013 Gupta A, Yu X, Case T, Paul M, Shen MM, Kaestner KH, Matusik RJ. Mash1 expression is induced in neuroendocrine prostate cancer upon the loss of Foxa2. The Prostate. 73: 582-9. PMID 23060003 DOI: 10.1002/pros.22598  0.52
2012 Li Z, Gadue P, Chen K, Jiao Y, Tuteja G, Schug J, Li W, Kaestner KH. Foxa2 and H2A.Z mediate nucleosome depletion during embryonic stem cell differentiation. Cell. 151: 1608-16. PMID 23260146 DOI: 10.1016/j.cell.2012.11.018  0.52
2012 Berkowitz KM, Sowash AR, Koenig LR, Urcuyo D, Khan F, Yang F, Wang PJ, Jongens TA, Kaestner KH. Disruption of CHTF18 causes defective meiotic recombination in male mice. Plos Genetics. 8: e1002996. PMID 23133398 DOI: 10.1371/journal.pgen.1002996  0.52
2012 Rieck S, Zhang J, Li Z, Liu C, Naji A, Takane KK, Fiaschi-Taesch NM, Stewart AF, Kushner JA, Kaestner KH. Overexpression of hepatocyte nuclear factor-4α initiates cell cycle entry, but is not sufficient to promote β-cell expansion in human islets. Molecular Endocrinology (Baltimore, Md.). 26: 1590-602. PMID 22798294 DOI: 10.1210/me.2012-1019  1
2012 Bochkis IM, Schug J, Ye DZ, Kurinna S, Stratton SA, Barton MC, Kaestner KH. Genome-wide location analysis reveals distinct transcriptional circuitry by paralogous regulators Foxa1 and Foxa2. Plos Genetics. 8: e1002770. PMID 22737085 DOI: 10.1371/journal.pgen.1002770  0.52
2012 Ionescu A, Kozhemyakina E, Nicolae C, Kaestner KH, Olsen BR, Lassar AB. FoxA family members are crucial regulators of the hypertrophic chondrocyte differentiation program. Developmental Cell. 22: 927-39. PMID 22595668 DOI: 10.1016/j.devcel.2012.03.011  0.52
2012 Khoo C, Yang J, Weinrott SA, Kaestner KH, Naji A, Schug J, Stoffers DA. Research resource: the pdx1 cistrome of pancreatic islets. Molecular Endocrinology (Baltimore, Md.). 26: 521-33. PMID 22322596 DOI: 10.1210/me.2011-1231  0.52
2012 Li Z, Tuteja G, Schug J, Kaestner KH. Foxa1 and Foxa2 are essential for sexual dimorphism in liver cancer. Cell. 148: 72-83. PMID 22265403 DOI: 10.1016/j.cell.2011.11.026  0.52
2012 Cui CY, Childress V, Piao Y, Michel M, Johnson AA, Kunisada M, Ko MS, Kaestner KH, Marmorstein AD, Schlessinger D. Forkhead transcription factor FoxA1 regulates sweat secretion through Bestrophin 2 anion channel and Na-K-Cl cotransporter 1. Proceedings of the National Academy of Sciences of the United States of America. 109: 1199-203. PMID 22223659 DOI: 10.1073/pnas.1117213109  0.52
2012 Liu L, Yannam GR, Nishikawa T, Yamamoto T, Basma H, Ito R, Nagaya M, Dutta-Moscato J, Stolz DB, Duan F, Kaestner KH, Vodovotz Y, Soto-Gutierrez A, Fox IJ. The microenvironment in hepatocyte regeneration and function in rats with advanced cirrhosis. Hepatology (Baltimore, Md.). 55: 1529-39. PMID 22109844 DOI: 10.1002/hep.24815  0.52
2011 Friedman JR, Kaestner KH. On the origin of the liver. The Journal of Clinical Investigation. 121: 4630-3. PMID 22105167 DOI: 10.1172/JCI59652  0.52
2011 Berger I, Ben-Neriah Z, Dor-Wolman T, Shaag A, Saada A, Zenvirt S, Raas-Rothschild A, Nadjari M, Kaestner KH, Elpeleg O. Early prenatal ventriculomegaly due to an AIFM1 mutation identified by linkage analysis and whole exome sequencing. Molecular Genetics and Metabolism. 104: 517-20. PMID 22019070 DOI: 10.1016/j.ymgme.2011.09.020  0.52
2011 Wan M, Leavens KF, Saleh D, Easton RM, Guertin DA, Peterson TR, Kaestner KH, Sabatini DM, Birnbaum MJ. Postprandial hepatic lipid metabolism requires signaling through Akt2 independent of the transcription factors FoxA2, FoxO1, and SREBP1c. Cell Metabolism. 14: 516-27. PMID 21982711 DOI: 10.1016/j.cmet.2011.09.001  0.52
2011 Liao X, Sharma N, Kapadia F, Zhou G, Lu Y, Hong H, Paruchuri K, Mahabeleshwar GH, Dalmas E, Venteclef N, Flask CA, Kim J, Doreian BW, Lu KQ, Kaestner KH, et al. Krüppel-like factor 4 regulates macrophage polarization Journal of Clinical Investigation. 121: 2736-2749. PMID 21670502 DOI: 10.1172/JCI45444  0.52
2011 Dorrell C, Erker L, Schug J, Kopp JL, Canaday PS, Fox AJ, Smirnova O, Duncan AW, Finegold MJ, Sander M, Kaestner KH, Grompe M. Prospective isolation of a bipotential clonogenic liver progenitor cell in adult mice. Genes & Development. 25: 1193-203. PMID 21632826 DOI: 10.1101/gad.2029411  0.52
2011 Shin S, Walton G, Aoki R, Brondell K, Schug J, Fox A, Smirnova O, Dorrell C, Erker L, Chu AS, Wells RG, Grompe M, Greenbaum LE, Kaestner KH. Foxl1-Cre-marked adult hepatic progenitors have clonogenic and bilineage differentiation potential. Genes & Development. 25: 1185-92. PMID 21632825 DOI: 10.1101/gad.2027811  0.52
2011 Li Z, Schug J, Tuteja G, White P, Kaestner KH. The nucleosome map of the mammalian liver. Nature Structural & Molecular Biology. 18: 742-6. PMID 21623366 DOI: 10.1038/nsmb.2060  0.52
2011 Miller RA, Chu Q, Le Lay J, Scherer PE, Ahima RS, Kaestner KH, Foretz M, Viollet B, Birnbaum MJ. Adiponectin suppresses gluconeogenic gene expression in mouse hepatocytes independent of LKB1-AMPK signaling. The Journal of Clinical Investigation. 121: 2518-28. PMID 21606593 DOI: 10.1172/JCI45942  0.52
2011 Matschinsky FM, Zelent B, Doliba NM, Kaestner KH, Vanderkooi JM, Grimsby J, Berthel SJ, Sarabu R. Research and development of glucokinase activators for diabetes therapy: theoretical and practical aspects. Handbook of Experimental Pharmacology. 357-401. PMID 21484579 DOI: 10.1007/978-3-642-17214-4_15  0.52
2011 Porat S, Weinberg-Corem N, Tornovsky-Babaey S, Schyr-Ben-Haroush R, Hija A, Stolovich-Rain M, Dadon D, Granot Z, Ben-Hur V, White P, Girard CA, Karni R, Kaestner KH, Ashcroft FM, Magnuson MA, et al. Control of pancreatic β cell regeneration by glucose metabolism. Cell Metabolism. 13: 440-9. PMID 21459328 DOI: 10.1016/j.cmet.2011.02.012  0.52
2011 Maloum F, Allaire JM, Gagné-Sansfaçon J, Roy E, Belleville K, Sarret P, Morisset J, Carrier JC, Mishina Y, Kaestner KH, Perreault N. Epithelial BMP signaling is required for proper specification of epithelial cell lineages and gastric endocrine cells. American Journal of Physiology. Gastrointestinal and Liver Physiology. 300: G1065-79. PMID 21415412 DOI: 10.1152/ajpgi.00176.2010  0.52
2011 Hill JT, Anderson KR, Mastracci TL, Kaestner KH, Sussel L. Novel computational analysis of protein binding array data identifies direct targets of Nkx2.2 in the pancreas. Bmc Bioinformatics. 12: 62. PMID 21352540 DOI: 10.1186/1471-2105-12-62  0.52
2011 Gao N, Davuluri G, Gong W, Seiler C, Lorent K, Furth EE, Kaestner KH, Pack M. The nuclear pore complex protein Elys is required for genome stability in mouse intestinal epithelial progenitor cells. Gastroenterology. 140: 1547-55.e10. PMID 21315719 DOI: 10.1053/j.gastro.2011.01.048  0.4
2011 Soccio RE, Tuteja G, Everett LJ, Li Z, Lazar MA, Kaestner KH. Species-specific strategies underlying conserved functions of metabolic transcription factors. Molecular Endocrinology (Baltimore, Md.). 25: 694-706. PMID 21292830 DOI: 10.1210/me.2010-0454  0.52
2011 Pellegrinet L, Rodilla V, Liu Z, Chen S, Koch U, Espinosa L, Kaestner KH, Kopan R, Lewis J, Radtke F. Dll1- and dll4-mediated notch signaling are required for homeostasis of intestinal stem cells. Gastroenterology. 140: 1230-1240.e1-7. PMID 21238454 DOI: 10.1053/j.gastro.2011.01.005  0.52
2011 Jeong Y, Dolson DK, Waclaw RR, Matise MP, Sussel L, Campbell K, Kaestner KH, Epstein DJ. Spatial and temporal requirements for sonic hedgehog in the regulation of thalamic interneuron identity. Development (Cambridge, England). 138: 531-41. PMID 21205797 DOI: 10.1242/dev.058917  0.52
2011 Gao Y, Schug J, McKenna LB, Le Lay J, Kaestner KH, Greenbaum LE. Tissue-specific regulation of mouse microRNA genes in endoderm-derived tissues. Nucleic Acids Research. 39: 454-63. PMID 20843784 DOI: 10.1093/nar/gkq782  0.52
2010 Haeusler RA, Kaestner KH, Accili D. FoxOs function synergistically to promote glucose production. The Journal of Biological Chemistry. 285: 35245-8. PMID 20880840 DOI: 10.1074/jbc.C110.175851  0.52
2010 McKenna LB, Schug J, Vourekas A, McKenna JB, Bramswig NC, Friedman JR, Kaestner KH. MicroRNAs control intestinal epithelial differentiation, architecture, and barrier function. Gastroenterology. 139: 1654-64, 1664.e1. PMID 20659473 DOI: 10.1053/j.gastro.2010.07.040  0.52
2010 Gao N, Kaestner KH. Cdx2 regulates endo-lysosomal function and epithelial cell polarity Genes and Development. 24: 1295-1305. PMID 20551175 DOI: 10.1101/gad.1921510  0.52
2010 Gao N, Le Lay J, Qin W, Doliba N, Schug J, Fox AJ, Smirnova O, Matschinsky FM, Kaestner KH. Foxa1 and Foxa2 maintain the metabolic and secretory features of the mature beta-cell. Molecular Endocrinology (Baltimore, Md.). 24: 1594-604. PMID 20534694 DOI: 10.1210/me.2009-0513  0.52
2010 Bernardo GM, Lozada KL, Miedler JD, Harburg G, Hewitt SC, Mosley JD, Godwin AK, Korach KS, Visvader JE, Kaestner KH, Abdul-Karim FW, Montano MM, Keri RA. FOXA1 is an essential determinant of ERalpha expression and mammary ductal morphogenesis. Development (Cambridge, England). 137: 2045-54. PMID 20501593 DOI: 10.1242/dev.043299  0.52
2010 Jeong JW, Kwak I, Lee KY, Kim TH, Large MJ, Stewart CL, Kaestner KH, Lydon JP, DeMayo FJ. Foxa2 is essential for mouse endometrial gland development and fertility. Biology of Reproduction. 83: 396-403. PMID 20484741 DOI: 10.1095/biolreprod.109.083154  0.52
2010 Gu C, Stein GH, Pan N, Goebbels S, Hörnberg H, Nave KA, Herrera P, White P, Kaestner KH, Sussel L, Lee JE. Pancreatic beta cells require NeuroD to achieve and maintain functional maturity. Cell Metabolism. 11: 298-310. PMID 20374962 DOI: 10.1016/j.cmet.2010.03.006  0.52
2010 Bhandare R, Schug J, Le Lay J, Fox A, Smirnova O, Liu C, Naji A, Kaestner KH. Genome-wide analysis of histone modifications in human pancreatic islets. Genome Research. 20: 428-33. PMID 20181961 DOI: 10.1101/gr.102038.109  0.52
2010 Le Lay J, Kaestner KH. The Fox genes in the liver: from organogenesis to functional integration. Physiological Reviews. 90: 1-22. PMID 20086072 DOI: 10.1152/physrev.00018.2009  0.56
2010 May CL, Kaestner KH. Gut endocrine cell development. Molecular and Cellular Endocrinology. 323: 70-5. PMID 20025933 DOI: 10.1016/j.mce.2009.12.009  0.52
2010 Rieck S, Kaestner KH. Expansion of beta-cell mass in response to pregnancy. Trends in Endocrinology and Metabolism: Tem. 21: 151-8. PMID 20015659 DOI: 10.1016/j.tem.2009.11.001  1
2010 Shibata W, Takaishi S, Muthupalani S, Pritchard DM, Whary MT, Rogers AB, Fox JG, Betz KS, Kaestner KH, Karin M, Wang TC. Conditional deletion of IkappaB-kinase-beta accelerates helicobacter-dependent gastric apoptosis, proliferation, and preneoplasia. Gastroenterology. 138: 1022-34.e1-10. PMID 19962981 DOI: 10.1053/j.gastro.2009.11.054  0.52
2010 Gleason CE, Ning Y, Cominski TP, Gupta R, Kaestner KH, Pintar JE, Birnbaum MJ. Role of insulin-like growth factor-binding protein 5 (IGFBP5) in organismal and pancreatic beta-cell growth. Molecular Endocrinology (Baltimore, Md.). 24: 178-92. PMID 19897600 DOI: 10.1210/me.2009-0167  0.52
2009 Anderson KR, White P, Kaestner KH, Sussel L. Identification of known and novel pancreas genes expressed downstream of Nkx2.2 during development. Bmc Developmental Biology. 9: 65. PMID 20003319 DOI: 10.1186/1471-213X-9-65  0.52
2009 Sackett SD, Gao Y, Shin S, Esterson YB, Tsingalia A, Hurtt RS, Brondell K, Kaestner KH, Greenbaum LE. Foxl1 promotes liver repair following cholestatic injury in mice. Laboratory Investigation; a Journal of Technical Methods and Pathology. 89: 1387-96. PMID 19841618 DOI: 10.1038/labinvest.2009.103  0.52
2009 Le Lay J, Tuteja G, White P, Dhir R, Ahima R, Kaestner KH. CRTC2 (TORC2) contributes to the transcriptional response to fasting in the liver but is not required for the maintenance of glucose homeostasis. Cell Metabolism. 10: 55-62. PMID 19583954 DOI: 10.1016/j.cmet.2009.06.006  1
2009 Rieck S, White P, Schug J, Fox AJ, Smirnova O, Gao N, Gupta RK, Wang ZV, Scherer PE, Keller MP, Attie AD, Kaestner KH. The transcriptional response of the islet to pregnancy in mice. Molecular Endocrinology (Baltimore, Md.). 23: 1702-12. PMID 19574445 DOI: 10.1210/me.2009-0144  1
2009 Tuteja G, White P, Schug J, Kaestner KH. Extracting transcription factor targets from ChIP-Seq data. Nucleic Acids Research. 37: e113. PMID 19553195 DOI: 10.1093/nar/gkp536  0.52
2009 Golson ML, Le Lay J, Gao N, Brämswig N, Loomes KM, Oakey R, May CL, White P, Kaestner KH. Jagged1 is a competitive inhibitor of Notch signaling in the embryonic pancreas. Mechanisms of Development. 126: 687-99. PMID 19501159 DOI: 10.1016/j.mod.2009.05.005  0.52
2009 Li Z, White P, Tuteja G, Rubins N, Sackett S, Kaestner KH. Foxa1 and Foxa2 regulate bile duct development in mice. The Journal of Clinical Investigation. 119: 1537-45. PMID 19436110 DOI: 10.1172/JCI38201  1
2009 Bochkis IM, Schug J, Rubins NE, Chopra AR, O'Malley BW, Kaestner KH. Foxa2-dependent hepatic gene regulatory networks depend on physiological state. Physiological Genomics. 38: 186-95. PMID 19417011 DOI: 10.1152/physiolgenomics.90376.2008  0.52
2009 Golson ML, Loomes KM, Oakey R, Kaestner KH. Ductal malformation and pancreatitis in mice caused by conditional Jag1 deletion. Gastroenterology. 136: 1761-71.e1. PMID 19208348 DOI: 10.1053/j.gastro.2009.01.040  0.8
2009 Sackett SD, Li Z, Hurtt R, Gao Y, Wells RG, Brondell K, Kaestner KH, Greenbaum LE. Foxl1 is a marker of bipotential hepatic progenitor cells in mice. Hepatology (Baltimore, Md.). 49: 920-9. PMID 19105206 DOI: 10.1002/hep.22705  0.52
2009 Madison BB, McKenna LB, Dolson D, Epstein DJ, Kaestner KH. FoxF1 and FoxL1 link hedgehog signaling and the control of epithelial proliferation in the developing stomach and intestine. The Journal of Biological Chemistry. 284: 5936-44. PMID 19049965 DOI: 10.1074/jbc.M808103200  0.52
2008 Gao N, LeLay J, Vatamaniuk MZ, Rieck S, Friedman JR, Kaestner KH. Dynamic regulation of Pdx1 enhancers by Foxa1 and Foxa2 is essential for pancreas development. Genes & Development. 22: 3435-48. PMID 19141476 DOI: 10.1101/gad.1752608  0.52
2008 Bochkis IM, Rubins NE, White P, Furth EE, Friedman JR, Kaestner KH. Hepatocyte-specific ablation of Foxa2 alters bile acid homeostasis and results in endoplasmic reticulum stress. Nature Medicine. 14: 828-36. PMID 18660816 DOI: 10.1038/nm.1853  0.52
2008 Tuteja G, Jensen ST, White P, Kaestner KH. Cis-regulatory modules in the mammalian liver: composition depends on strength of Foxa2 consensus site. Nucleic Acids Research. 36: 4149-57. PMID 18556755 DOI: 10.1093/nar/gkn366  1
2007 Tuteja G, Kaestner KH. Forkhead transcription factors II. Cell. 131: 192. PMID 17923097 DOI: 10.1016/j.cell.2007.09.016  1
2007 Gao N, White P, Doliba N, Golson ML, Matschinsky FM, Kaestner KH. Foxa2 controls vesicle docking and insulin secretion in mature Beta cells. Cell Metabolism. 6: 267-79. PMID 17908556 DOI: 10.1016/j.cmet.2007.08.015  0.8
2007 Tuteja G, Kaestner KH. SnapShot: forkhead transcription factors I. Cell. 130: 1160. PMID 17889656 DOI: 10.1016/j.cell.2007.09.005  1
2007 Sackett SD, Fulmer JT, Friedman JR, Kaestner KH. Foxl1-Cre BAC transgenic mice: a new tool for gene ablation in the gastrointestinal mesenchyme. Genesis (New York, N.Y. : 2000). 45: 518-22. PMID 17661401 DOI: 10.1002/dvg.20315  0.52
2007 Behr R, Sackett SD, Bochkis IM, Le PP, Kaestner KH. Impaired male fertility and atrophy of seminiferous tubules caused by haploinsufficiency for Foxa3. Developmental Biology. 306: 636-45. PMID 17488644 DOI: 10.1016/j.ydbio.2007.03.525  0.52
2007 Gupta RK, Gao N, Gorski RK, White P, Hardy OT, Rafiq K, Brestelli JE, Chen G, Stoeckert CJ, Kaestner KH. Expansion of adult beta-cell mass in response to increased metabolic demand is dependent on HNF-4alpha. Genes & Development. 21: 756-69. PMID 17403778 DOI: 10.1101/gad.1535507  0.52
2007 Hardy OT, Hohmeier HE, Becker TC, Manduchi E, Doliba NM, Gupta RK, White P, Stoeckert CJ, Matschinsky FM, Newgard CB, Kaestner KH. Functional genomics of the beta-cell: short-chain 3-hydroxyacyl-coenzyme A dehydrogenase regulates insulin secretion independent of K+ currents. Molecular Endocrinology (Baltimore, Md.). 21: 765-73. PMID 17185391 DOI: 10.1210/me.2006-0411  0.52
2006 Vatamaniuk MZ, Gupta RK, Lantz KA, Doliba NM, Matschinsky FM, Kaestner KH. Foxa1-deficient mice exhibit impaired insulin secretion due to uncoupled oxidative phosphorylation. Diabetes. 55: 2730-6. PMID 17003337 DOI: 10.2337/db05-0470  0.92
2006 Zelent D, Golson ML, Koeberlein B, Quintens R, van Lommel L, Buettger C, Weik-Collins H, Taub R, Grimsby J, Schuit F, Kaestner KH, Matschinsky FM. A glucose sensor role for glucokinase in anterior pituitary cells. Diabetes. 55: 1923-9. PMID 16804059 DOI: 10.2337/db06-0151  0.8
2005 Phuc Le P, Friedman JR, Schug J, Brestelli JE, Parker JB, Bochkis IM, Kaestner KH. Glucocorticoid receptor-dependent gene regulatory networks. Plos Genetics. 1: e16. PMID 16110340 DOI: 10.1371/journal.pgen.0010016  0.52
2005 Gupta RK, Vatamaniuk MZ, Lee CS, Flaschen RC, Fulmer JT, Matschinsky FM, Duncan SA, Kaestner KH. The MODY1 gene HNF-4alpha regulates selected genes involved in insulin secretion. The Journal of Clinical Investigation. 115: 1006-15. PMID 15761495 DOI: 10.1172/JCI22365  0.92
2005 Perreault N, Sackett SD, Katz JP, Furth EE, Kaestner KH. Foxl1 is a mesenchymal Modifier of Min in carcinogenesis of stomach and colon. Genes & Development. 19: 311-5. PMID 15650110 DOI: 10.1101/gad.1260605  0.52
2005 Lantz KA, Kaestner KH. Winged-helix transcription factors and pancreatic development. Clinical Science (London, England : 1979). 108: 195-204. PMID 15631623 DOI: 10.1042/CS20040309  0.84
2004 Gupta RK, Kaestner KH. HNF-4alpha: from MODY to late-onset type 2 diabetes. Trends in Molecular Medicine. 10: 521-4. PMID 15519277 DOI: 10.1016/j.molmed.2004.09.004  0.92
2004 Lantz KA, Vatamaniuk MZ, Brestelli JE, Friedman JR, Matschinsky FM, Kaestner KH. Foxa2 regulates multiple pathways of insulin secretion. The Journal of Clinical Investigation. 114: 512-20. PMID 15314688 DOI: 10.1172/JCI21149  0.52
2003 Kaestner KH, Lee CS, Scearce LM, Brestelli JE, Arsenlis A, Le PP, Lantz KA, Crabtree J, Pizarro A, Mazzarelli J, Pinney D, Fischer S, Manduchi E, Stoeckert CJ, Gradwohl G, et al. Transcriptional program of the endocrine pancreas in mice and humans. Diabetes. 52: 1604-10. PMID 12829622  0.52
2002 Silberg DG, Sullivan J, Kang E, Swain GP, Moffett J, Sund NJ, Sackett SD, Kaestner KH. Cdx2 ectopic expression induces gastric intestinal metaplasia in transgenic mice. Gastroenterology. 122: 689-96. PMID 11875002  0.52
2001 Perreault N, Katz JP, Sackett SD, Kaestner KH. Foxl1 controls the Wnt/beta-catenin pathway by modulating the expression of proteoglycans in the gut. The Journal of Biological Chemistry. 276: 43328-33. PMID 11555641 DOI: 10.1074/jbc.M104366200  0.52
2000 Sund NJ, Ang SL, Sackett SD, Shen W, Daigle N, Magnuson MA, Kaestner KH. Hepatocyte nuclear factor 3β (Foxa2) is dispensable for maintaining the differentiated state of the adult hepatocyte Molecular and Cellular Biology. 20: 5175-5183. PMID 10866673 DOI: 10.1128/MCB.20.14.5175-5183.2000  0.52
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