John D. Schuetz - Publications

Affiliations: 
Pharmaceutical Sciences University of Tennessee Health Science Center, Memphis, TN, United States 
Area:
Cell Biology, Physiology Biology

102 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

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Year Citation  Score
2020 Wijaya J, Gose T, Schuetz JD. Using Pharmacology to Squeeze the Life Out of Childhood Leukemia, and Potential Strategies to Achieve Breakthroughs in Medulloblastoma Treatment. Pharmacological Reviews. 72: 668-691. PMID 32571983 DOI: 10.1124/pr.118.016824  0.4
2020 Gose T, Shafi T, Fukuda Y, Das S, Wang Y, Allcock A, Gavan McHarg A, Lynch J, Chen T, Tamai I, Shelat A, Ford RC, Schuetz JD. ABCG2 requires a single aromatic amino acid to "clamp" substrates and inhibitors into the binding pocket. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. PMID 32067270 DOI: 10.1096/fj.201902338RR  0.96
2020 Wijaya J, Vo BT, Liu J, Xu B, Wu G, Wang Y, Peng J, Zhang J, Janke LJ, Orr BA, Yu J, Roussel MF, Schuetz JD. An ABC transporter drives medulloblastoma pathogenesis by regulating Sonic Hedgehog signaling. Cancer Research. PMID 31948942 DOI: 10.1158/0008-5472.CAN-19-2054  0.4
2019 O'Reilly C, Cho JH, Qi Q, Peters JL, Fukuda Y, Frase S, Peng J, Schuetz JD, Cheng Y, Yoon SO, Han MJ. Corrigendum to "Metabolic switching in pluripotent stem cells reorganizes energy metabolism and subcellular organelles" [379 (2019) 55-64]. Experimental Cell Research. PMID 31079852 DOI: 10.1016/j.yexcr.2019.05.002  0.96
2019 O'Reilly C, Cho JH, Qi Q, Peters JL, Fukuda Y, Frase S, Peng J, Schuetz JD, Cheng Y, Yoon SO, Han MJ. Metabolic switching in pluripotent stem cells reorganizes energy metabolism and subcellular organelles. Experimental Cell Research. PMID 30922922 DOI: 10.1016/j.yexcr.2019.03.028  0.96
2017 Boswell-Casteel RC, Fukuda Y, Schuetz JD. ABCB6, an ABC Transporter Impacting Drug Response and Disease. The Aaps Journal. 20: 8. PMID 29192381 DOI: 10.1208/s12248-017-0165-6  0.96
2017 Wijaya J, Fukuda Y, Schuetz JD. Obstacles to Brain Tumor Therapy: Key ABC Transporters. International Journal of Molecular Sciences. 18. PMID 29186899 DOI: 10.3390/ijms18122544  0.96
2017 Pitre A, Ge Y, Lin W, Wang Y, Fukuda Y, Temirov J, Phillips AH, Peters JL, Fan Y, Ma J, Nourse A, Sinha C, Lin H, Kriwacki R, Downing JR, ... ... Schuetz JD, et al. An unexpected protein interaction promotes drug resistance in leukemia. Nature Communications. 8: 1547. PMID 29146910 DOI: 10.1038/s41467-017-01678-y  0.96
2017 Fukuda Y, Wang Y, Lian S, Lynch J, Nagai S, Fanshawe B, Kandilci A, Janke LJ, Neale G, Fan Y, Sorrentino BP, Roussel MF, Grosveld G, Schuetz JD. Upregulated heme biosynthesis, an exploitable vulnerability in MYCN-driven leukemogenesis. Jci Insight. 2. PMID 28768907 DOI: 10.1172/jci.insight.92409  0.96
2016 Fukuda Y, Cheong PL, Lynch J, Brighton C, Frase S, Kargas V, Rampersaud E, Wang Y, Sankaran VG, Yu B, Ney PA, Weiss MJ, Vogel P, Bond PJ, Ford RC, ... ... Schuetz JD, et al. The severity of hereditary porphyria is modulated by the porphyrin exporter and Lan antigen ABCB6. Nature Communications. 7: 12353. PMID 27507172 DOI: 10.1038/ncomms12353  0.92
2015 Morgan JA, Lynch J, Panetta JC, Wang Y, Frase S, Bao J, Zheng J, Opferman JT, Janke L, Green DM, Chemaitilly W, Schuetz JD. Apoptosome activation, an important molecular instigator in 6-mercaptopurine induced Leydig cell death. Scientific Reports. 5: 16488. PMID 26576726 DOI: 10.1038/srep16488  0.92
2015 Zhang Y, Li F, Wang Y, Pitre A, Fang ZZ, Frank MW, Calabrese C, Krausz KW, Neale G, Frase S, Vogel P, Rock CO, Gonzalez FJ, Schuetz JD. Maternal bile acid transporter deficiency promotes neonatal demise. Nature Communications. 6: 8186. PMID 26416771 DOI: 10.1038/ncomms9186  0.92
2015 Cheepala SB, Pitre A, Fukuda Y, Takenaka K, Zhang Y, Wang Y, Frase S, Pestina T, Gartner TK, Jackson C, Schuetz JD. ABCC4, a plasma membrane transporter modulating platelet aggregation. Blood. PMID 26405223 DOI: 10.1182/blood-2014-08-595942  0.92
2015 Morfouace M, Cheepala S, Jackson S, Fukuda Y, Patel YT, Fatima S, Kawauchi D, Shelat AA, Stewart CF, Sorrentino BP, Schuetz JD, Roussel MF. ABCG2 Transporter Expression Impacts Group 3 Medulloblastoma Response to Chemotherapy. Cancer Research. PMID 26199091 DOI: 10.1158/0008-5472.CAN-15-0030  0.92
2015 Sinha C, Ren A, Arora K, Moon CS, Yarlagadda S, Woodrooffe K, Lin S, Schuetz JD, Ziady AG, Naren AP. PKA and actin play critical roles as downstream effectors in MRP4-mediated regulation of fibroblast migration. Cellular Signalling. 27: 1345-55. PMID 25841995 DOI: 10.1016/j.cellsig.2015.03.022  0.92
2015 Moon C, Zhang W, Ren A, Arora K, Sinha C, Yarlagadda S, Woodrooffe K, Schuetz JD, Valasani KR, de Jonge HR, Shanmukhappa SK, Shata MT, Buddington RK, Parthasarathi K, Naren AP. Compartmentalized accumulation of cAMP near complexes of multidrug resistance protein 4 (MRP4) and cystic fibrosis transmembrane conductance regulator (CFTR) contributes to drug-induced diarrhea. The Journal of Biological Chemistry. 290: 11246-57. PMID 25762723 DOI: 10.1074/jbc.M114.605410  0.92
2015 Fukuda Y, Lian S, Schuetz JD. Leukemia and ABC Transporters Advances in Cancer Research. 125: 171-196. PMID 25640270 DOI: 10.1016/bs.acr.2014.10.006  0.92
2015 Li-Harms X, Milasta S, Lynch J, Wright C, Joshi A, Iyengar R, Neale G, Wang X, Wang YD, Prolla TA, Thompson JE, Opferman JT, Green DR, Schuetz J, Kundu M. Mito-protective autophagy is impaired in erythroid cells of aged mtDNA-mutator mice. Blood. 125: 162-74. PMID 25411424 DOI: 10.1182/blood-2014-07-586396  0.92
2014 Jin D, Ni TT, Sun J, Wan H, Amack JD, Yu G, Fleming J, Chiang C, Li W, Papierniak A, Cheepala S, Conseil G, Cole SP, Zhou B, Drummond IA, ... Schuetz JD, et al. Prostaglandin signalling regulates ciliogenesis by modulating intraflagellar transport. Nature Cell Biology. 16: 841-51. PMID 25173977 DOI: 10.1038/ncb3029  0.92
2014 Schuetz JD, Swaan PW, Tweedie DJ. The role of transporters in toxicity and disease Drug Metabolism and Disposition. 42: 541-545. PMID 24598705 DOI: 10.1124/dmd.114.057539  0.92
2014 Murphy AJ, Sarrazy V, Wang N, Bijl N, Abramowicz S, Westerterp M, Welch CB, Schuetz JD, Yvan-Charvet L. Deficiency of ATP-binding cassette transporter B6 in megakaryocyte progenitors accelerates atherosclerosis in mice. Arteriosclerosis, Thrombosis, and Vascular Biology. 34: 751-8. PMID 24504733 DOI: 10.1161/ATVBAHA.113.302613  0.92
2013 Haslam IS, Pitre A, Schuetz JD, Paus R. Protection against chemotherapy-induced alopecia: targeting ATP-binding cassette transporters in the hair follicle? Trends in Pharmacological Sciences. 34: 599-604. PMID 24100054 DOI: 10.1016/j.tips.2013.09.001  0.92
2013 Furmanski BD, Hu S, Fujita K, Li L, Gibson AA, Janke LJ, Williams RT, Schuetz JD, Sparreboom A, Baker SD. Contribution of ABCC4-mediated gastric transport to the absorption and efficacy of dasatinib. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 19: 4359-70. PMID 23794731 DOI: 10.1158/1078-0432.CCR-13-0980  0.92
2013 Fukuda Y, Takenaka K, Sparreboom A, Cheepala SB, Wu CP, Ekins S, Ambudkar SV, Schuetz JD. Human immunodeficiency virus protease inhibitors interact with ATP binding cassette transporter 4/multidrug resistance protein 4: a basis for unanticipated enhanced cytotoxicity. Molecular Pharmacology. 84: 361-71. PMID 23775562 DOI: 10.1124/mol.113.086967  0.96
2013 Cheepala SB, Bao J, Nachagari D, Sun D, Wang Y, Zhong TP, Zhong T, Naren AP, Zheng J, Schuetz JD. Crucial role for phylogenetically conserved cytoplasmic loop 3 in ABCC4 protein expression. The Journal of Biological Chemistry. 288: 22207-18. PMID 23766510 DOI: 10.1074/jbc.M113.476218  0.92
2013 Sinha C, Ren A, Arora K, Moon CS, Yarlagadda S, Zhang W, Cheepala SB, Schuetz JD, Naren AP. Multi-drug resistance protein 4 (MRP4)-mediated regulation of fibroblast cell migration reflects a dichotomous role of intracellular cyclic nucleotides. The Journal of Biological Chemistry. 288: 3786-94. PMID 23264633 DOI: 10.1074/jbc.M112.435925  0.92
2013 Cheepala S, Hulot JS, Morgan JA, Sassi Y, Zhang W, Naren AP, Schuetz JD. Cyclic nucleotide compartmentalization: contributions of phosphodiesterases and ATP-binding cassette transporters. Annual Review of Pharmacology and Toxicology. 53: 231-53. PMID 23072381 DOI: 10.1146/annurev-pharmtox-010611-134609  0.92
2013 Cheepala SB, Bao J, Nachagari D, Sun D, Wang Y, Zhong TP, Naren AP, Zheng J, Schuetz JD. Crucial role for phylogenetically conserved cytoplasmic loop 3 in ABCC4 protein expression (Journal of Biological Chemistry (2013) 288 (22207-22218)) Journal of Biological Chemistry. 288: 26821. DOI: 10.1074/jbc.A113.476218  0.92
2013 Cheepala SB, Sukthankar M, Schuetz JD. MRP4 (ABCC4) Pharmacogenomics of Human Drug Transporters: Clinical Impacts. 365-385. DOI: 10.1002/9781118353240.ch16  0.92
2012 Perciavalle RM, Stewart DP, Koss B, Lynch J, Milasta S, Bathina M, Temirov J, Cleland MM, Pelletier S, Schuetz JD, Youle RJ, Green DR, Opferman JT. Anti-apoptotic MCL-1 localizes to the mitochondrial matrix and couples mitochondrial fusion to respiration Nature Cell Biology. 14: 575-583. PMID 22544066 DOI: 10.1038/ncb2488  0.92
2012 Ulrich DL, Lynch J, Wang Y, Fukuda Y, Nachagari D, Du G, Sun D, Fan Y, Tsurkan L, Potter PM, Rehg JE, Schuetz JD. ATP-dependent mitochondrial porphyrin importer ABCB6 protects against phenylhydrazine toxicity. The Journal of Biological Chemistry. 287: 12679-90. PMID 22294697 DOI: 10.1074/jbc.M111.336180  0.92
2012 Fukuda Y, Schuetz JD. ABC transporters and their role in nucleoside and nucleotide drug resistance Biochemical Pharmacology. 83: 1073-1083. PMID 22285911 DOI: 10.1016/j.bcp.2011.12.042  0.92
2011 Andersson AK, Miller DW, Lynch JA, Lemoff AS, Cai Z, Pounds SB, Radtke I, Yan B, Schuetz JD, Rubnitz JE, Ribeiro RC, Raimondi SC, Zhang J, Mullighan CG, Shurtleff SA, et al. IDH1 and IDH2 mutations in pediatric acute leukemia. Leukemia. 25: 1570-7. PMID 21647154 DOI: 10.1038/leu.2011.133  0.92
2011 Fukuda Y, Aguilar-Bryan L, Vaxillaire M, Dechaume A, Wang Y, Dean M, Moitra K, Bryan J, Schuetz JD. Conserved intramolecular disulfide bond is critical to trafficking and fate of ATP-binding cassette (ABC) transporters ABCB6 and sulfonylurea receptor 1 (SUR1)/ABCC8. The Journal of Biological Chemistry. 286: 8481-92. PMID 21199866 DOI: 10.1074/jbc.M110.174516  0.92
2011 Krishnamurthy P, Schuetz JD. The role of ABCG2 and ABCB6 in porphyrin metabolism and cell survival. Current Pharmaceutical Biotechnology. 12: 647-55. PMID 21118089 DOI: 10.2174/138920111795163995  0.92
2010 Li C, Schuetz JD, Naren AP. Tobacco carcinogen NNK transporter MRP2 regulates CFTR function in lung epithelia: implications for lung cancer. Cancer Letters. 292: 246-53. PMID 20089353 DOI: 10.1016/j.canlet.2009.12.009  0.92
2009 Lynch J, Fukuda Y, Krishnamurthy P, Du G, Schuetz JD. Cell survival under stress is enhanced by a mitochondrial ATP-binding cassette transporter that regulates hemoproteins. Cancer Research. 69: 5560-7. PMID 19549895 DOI: 10.1158/0008-5472.CAN-09-0078  0.92
2008 Kitamura Y, Hirouchi M, Kusuhara H, Schuetz JD, Sugiyama Y. Increasing systemic exposure of methotrexate by active efflux mediated by multidrug resistance-associated protein 3 (Mrp3/Abcc3) Journal of Pharmacology and Experimental Therapeutics. 327: 465-473. PMID 18719291 DOI: 10.1124/jpet.108.140475  0.92
2007 Li C, Krishnamurthy PC, Penmatsa H, Marrs KL, Wang XQ, Zaccolo M, Jalink K, Li M, Nelson DJ, Schuetz JD, Naren AP. Spatiotemporal coupling of cAMP transporter to CFTR chloride channel function in the gut epithelia. Cell. 131: 940-51. PMID 18045536 DOI: 10.1016/j.cell.2007.09.037  0.92
2007 Takenaka K, Morgan JA, Scheffer GL, Adachi M, Stewart CF, Sun D, Leggas M, Ejendal KF, Hrycyna CA, Schuetz JD. Substrate overlap between Mrp4 and Abcg2/Bcrp affects purine analogue drug cytotoxicity and tissue distribution. Cancer Research. 67: 6965-72. PMID 17638908 DOI: 10.1158/0008-5472.CAN-06-4720  0.92
2007 Krishnamurthy P, Xie T, Schuetz JD. The role of transporters in cellular heme and porphyrin homeostasis. Pharmacology & Therapeutics. 114: 345-58. PMID 17368550 DOI: 10.1016/j.pharmthera.2007.02.001  0.92
2007 de Wolf CJ, Yamaguchi H, van der Heijden I, Wielinga PR, Hundscheid SL, Ono N, Scheffer GL, de Haas M, Schuetz JD, Wijnholds J, Borst P. cGMP transport by vesicles from human and mouse erythrocytes. The Febs Journal. 274: 439-50. PMID 17229149 DOI: 10.1111/j.1742-4658.2006.05591.x  0.92
2006 Kleemann P, Casper B, Huber M, Schuetz JD, Lohoff M. Multidrug-resistance-associated protein 1 (Mrp1) is probably not required for murine Th cell activation International Immunology. 18: 1603-1606. PMID 17008412 DOI: 10.1093/intimm/dxl094  0.92
2006 Krishnamurthy PC, Du G, Fukuda Y, Sun D, Sampath J, Mercer KE, Wang J, Sosa-Pineda B, Murti KG, Schuetz JD. Identification of a mammalian mitochondrial porphyrin transporter. Nature. 443: 586-9. PMID 17006453 DOI: 10.1038/nature05125  0.92
2006 Lamba JK, Chen X, Lan LB, Kim JW, Wei Wang X, Relling MV, Kazuto Y, Watkins PB, Strom S, Sun D, Schuetz JD, Schuetz EG. Increased CYP3A4 copy number in TONG/HCC cells but not in DNA from other humans. Pharmacogenetics and Genomics. 16: 415-27. PMID 16708050 DOI: 10.1097/01.fpc.0000194421.35641.70  0.92
2006 Leggas M, Panetta JC, Zhuang Y, Schuetz JD, Johnston B, Bai F, Sorrentino B, Zhou S, Houghton PJ, Stewart CF. Gefitinib modulates the function of multiple ATP-binding cassette transporters in vivo. Cancer Research. 66: 4802-7. PMID 16651435 DOI: 10.1158/0008-5472.CAN-05-2915  0.92
2006 Mennone A, Soroka CJ, Cai SY, Harry K, Adachi M, Hagey L, Schuetz JD, Boyer JL. Mrp4-/- mice have an impaired cytoprotective response in obstructive cholestasis. Hepatology (Baltimore, Md.). 43: 1013-21. PMID 16628672 DOI: 10.1002/hep.21158  0.92
2006 Krishnamurthy P, Schuetz JD. Role of ABCG2/BCRP in biology and medicine. Annual Review of Pharmacology and Toxicology. 46: 381-410. PMID 16402910 DOI: 10.1146/annurev.pharmtox.46.120604.141238  0.92
2006 Johnson BM, Zhang P, Schuetz JD, Brouwer KL. Characterization of transport protein expression in multidrug resistance-associated protein (Mrp) 2-deficient rats. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 34: 556-62. PMID 16204465 DOI: 10.1124/dmd.105.005793  0.92
2005 Krishnamurthy P, Schuetz JD. The ABC transporter Abcg2/Bcrp: role in hypoxia mediated survival. Biometals : An International Journal On the Role of Metal Ions in Biology, Biochemistry, and Medicine. 18: 349-58. PMID 16158227 DOI: 10.1007/s10534-005-3709-7  0.92
2005 Masson D, Lagrost L, Athias A, Gambert P, Brimer-Cline C, Lan L, Schuetz JD, Schuetz EG, Assem M. Expression of the pregnane X receptor in mice antagonizes the cholic acid-mediated changes in plasma lipoprotein profile Arteriosclerosis, Thrombosis, and Vascular Biology. 25: 2164-2169. PMID 16123326 DOI: 10.1161/01.ATV.0000183674.88817.fb  0.92
2005 Ozvegy-Laczka C, Várady G, Köblös G, Ujhelly O, Cervenak J, Schuetz JD, Sorrentino BP, Koomen GJ, Váradi A, Német K, Sarkadi B. Function-dependent conformational changes of the ABCG2 multidrug transporter modify its interaction with a monoclonal antibody on the cell surface. The Journal of Biological Chemistry. 280: 4219-27. PMID 15557326 DOI: 10.1074/jbc.M411338200  0.92
2004 Stewart CF, Leggas M, Schuetz JD, Panetta JC, Cheshire PJ, Peterson J, Daw N, Jenkins JJ, Gilbertson R, Germain GS, Harwood FC, Houghton PJ. Gefitinib enhances the antitumor activity and oral bioavailability of irinotecan in mice. Cancer Research. 64: 7491-9. PMID 15492275 DOI: 10.1158/0008-5472.CAN-04-0096  0.92
2004 Leggas M, Adachi M, Scheffer GL, Sun D, Wielinga P, Du G, Mercer KE, Zhuang Y, Panetta JC, Johnston B, Scheper RJ, Stewart CF, Schuetz JD. Mrp4 confers resistance to topotecan and protects the brain from chemotherapy. Molecular and Cellular Biology. 24: 7612-21. PMID 15314169 DOI: 10.1128/MCB.24.17.7612-7621.2004  0.92
2004 Zhang Y, Schuetz JD, Elmquist WF, Miller DW. Plasma membrane localization of multidrug resistance-associated protein homologs in brain capillary endothelial cells. The Journal of Pharmacology and Experimental Therapeutics. 311: 449-55. PMID 15218051 DOI: 10.1124/jpet.104.068528  0.92
2004 Houghton PJ, Germain GS, Harwood FC, Schuetz JD, Stewart CF, Buchdunger E, Traxler P. Imatinib mesylate is a potent inhibitor of the ABCG2 (BCRP) transporter and reverses resistance to topotecan and SN-38 in vitro. Cancer Research. 64: 2333-7. PMID 15059881 DOI: 10.1158/0008-5472.CAN-03-3344  0.92
2004 Krishnamurthy P, Ross DD, Nakanishi T, Bailey-Dell K, Zhou S, Mercer KE, Sarkadi B, Sorrentino BP, Schuetz JD. The stem cell marker Bcrp/ABCG2 enhances hypoxic cell survival through interactions with heme. The Journal of Biological Chemistry. 279: 24218-25. PMID 15044468 DOI: 10.1074/jbc.M313599200  0.92
2004 Denk GU, Soroka CJ, Takeyama Y, Chen WS, Schuetz JD, Boyer JL. Multidrug resistance-associated protein 4 is up-regulated in liver but down-regulated in kidney in obstructive cholestasis in the rat Journal of Hepatology. 40: 585-591. PMID 15030973 DOI: 10.1016/j.jhep.2003.12.001  0.92
2004 Assem M, Schuetz EG, Leggas M, Sun D, Yasuda K, Reid G, Zelcer N, Adachi M, Strom S, Evans RM, Moore DD, Borst P, Schuetz JD. Interactions between hepatic Mrp4 and Sult2a as revealed by the constitutive androstane receptor and Mrp4 knockout mice. The Journal of Biological Chemistry. 279: 22250-7. PMID 15004017 DOI: 10.1074/jbc.M314111200  0.92
2003 Wagner M, Fickert P, Zollner G, Fuchsbichler A, Silbert D, Tsybrovskyy O, Zatloukal K, Guo GL, Schuetz JD, Gonzalez FJ, Marschall HU, Denk H, Trauner M. Role of farnesoid X receptor in determining hepatic ABC transporter expression and liver injury in bile duct-ligated mice. Gastroenterology. 125: 825-38. PMID 12949728 DOI: 10.1016/S0016-5085(03)01068-0  0.92
2003 Wierdl M, Wall A, Morton CL, Sampath J, Danks MK, Schuetz JD, Potter PM. Carboxylesterase-mediated sensitization of human tumor cells to CPT-11 cannot override ABCG2-mediated drug resistance. Molecular Pharmacology. 64: 279-88. PMID 12869632 DOI: 10.1124/mol.64.2.279  0.92
2003 Zamber CP, Lamba JK, Yasuda K, Farnum J, Thummel K, Schuetz JD, Schuetz EG. Natural allelic variants of breast cancer resistance protein (BCRP) and their relationship to BCRP expression in human intestine. Pharmacogenetics. 13: 19-28. PMID 12544509 DOI: 10.1097/00008571-200301000-00004  0.92
2003 Wierdl M, Morton CL, Harris LC, Danks MK, Schuetz JD, Potter PM. p53-mediated regulation of expression of a rabbit liver carboxylesterase confers sensitivity to 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin (CPT-11). The Journal of Pharmacology and Experimental Therapeutics. 304: 699-705. PMID 12538824 DOI: 10.1124/jpet.102.044149  0.92
2003 Zelcer N, Reid G, Wielinga P, Kuil A, van der Heijden I, Schuetz JD, Borst P. Steroid and bile acid conjugates are substrates of human multidrug-resistance protein (MRP) 4 (ATP-binding cassette C4). The Biochemical Journal. 371: 361-7. PMID 12523936 DOI: 10.1042/BJ20021886  0.92
2003 Lamba JK, Adachi M, Sun D, Tammur J, Schuetz EG, Allikmets R, Schuetz JD. Nonsense mediated decay downregulates conserved alternatively spliced ABCC4 transcripts bearing nonsense codons. Human Molecular Genetics. 12: 99-109. PMID 12499391 DOI: 10.1093/hmg/ddg011  0.92
2002 Wielinga PR, Reid G, Challa EE, van der Heijden I, van Deemter L, de Haas M, Mol C, Kuil AJ, Groeneveld E, Schuetz JD, Brouwer C, De Abreu RA, Wijnholds J, Beijnen JH, Borst P. Thiopurine metabolism and identification of the thiopurine metabolites transported by MRP4 and MRP5 overexpressed in human embryonic kidney cells. Molecular Pharmacology. 62: 1321-31. PMID 12435799 DOI: 10.1124/mol.62.6.1321  0.92
2002 Adachi M, Reid G, Schuetz JD. Therapeutic and biological importance of getting nucleotides out of cells: A case for the ABC transporters, MRP4 and 5 Advanced Drug Delivery Reviews. 54: 1333-1342. PMID 12406648 DOI: 10.1016/S0169-409X(02)00166-7  0.92
2002 Yasuda K, Lan LB, Sanglard D, Furuya K, Schuetz JD, Schuetz EG. Interaction of cytochrome P450 3A inhibitors with P-glycoprotein Journal of Pharmacology and Experimental Therapeutics. 303: 323-332. PMID 12235267 DOI: 10.1124/jpet.102.037549  0.92
2002 Zhou S, Morris JJ, Barnes Y, Lan L, Schuetz JD, Sorrentino BP. Bcrp1 gene expression is required for normal numbers of side population stem cells in mice, and confers relative protection to mitoxantrone in hematopoietic cells in vivo. Proceedings of the National Academy of Sciences of the United States of America. 99: 12339-44. PMID 12218177 DOI: 10.1073/pnas.192276999  0.92
2002 Schuetz E, Lan L, Yasuda K, Kim R, Kocarek TA, Schuetz J, Strom S. Development of a real-time in vivo transcription assay: Application reveals pregnane X receptor-mediated induction of CYP3A4 by cancer chemotherapeutic agents Molecular Pharmacology. 62: 439-445. PMID 12181418 DOI: 10.1124/mol.62.3.439  0.92
2002 Ekins S, Kim RB, Leake BF, Dantzig AH, Schuetz EG, Lan LB, Yasuda K, Shepard RL, Winter MA, Schuetz JD, Wikel JH, Wrighton SA. Application of three-dimensional quantitative structure-activity relationships of P-glycoprotein inhibitors and substrates. Molecular Pharmacology. 61: 974-81. PMID 11961114 DOI: 10.1124/mol.61.5.974  0.92
2002 Ekins S, Kim RB, Leake BF, Dantzig AH, Schuetz EG, Lan LB, Yasuda K, Shepard RL, Winter MA, Schuetz JD, Wikel JH, Wrighton SA. Three-dimensional quantitative structure-activity relationships of inhibitors of P-glycoprotein. Molecular Pharmacology. 61: 964-73. PMID 11961113 DOI: 10.1124/mol.61.5.964  0.92
2001 Zhou S, Schuetz JD, Bunting KD, Colapietro AM, Sampath J, Morris JJ, Lagutina I, Grosveld GC, Osawa M, Nakauchi H, Sorrentino BP. The ABC transporter Bcrp1/ABCG2 is expressed in a wide variety of stem cells and is a molecular determinant of the side-population phenotype. Nature Medicine. 7: 1028-34. PMID 11533706 DOI: 10.1038/nm0901-1028  0.92
2001 Sampath J, Sun D, Kidd VJ, Grenet J, Gandhi A, Shapiro LH, Wang Q, Zambetti GP, Schuetz JD. Mutant p53 Cooperates with ETS and Selectively Up-regulates Human MDR1 Not MRP1 Journal of Biological Chemistry. 276: 39359-39367. PMID 11483599 DOI: 10.1074/jbc.M103429200  0.92
2001 Lecureur V, Thottassery JV, Sun D, Schuetz EG, Lahti J, Zambetti GP, Schuetz JD. Mdr1b facilitates p53-mediated cell death and p53 is required for Mdr1b upregulation in vivo Oncogene. 20: 303-313. PMID 11313959 DOI: 10.1038/sj.onc.1204065  0.92
2001 Ding BC, Whetstine JR, Witt TL, Schuetz JD, Matherly LH. Repression of human reduced folate carrier gene expression by wild type p53. The Journal of Biological Chemistry. 276: 8713-9. PMID 11106643 DOI: 10.1074/jbc.M005248200  0.92
1999 Edwards DJ, Fitzsimmons ME, Schuetz EG, Yasuda K, Ducharme MP, Warbasse LH, Woster PM, Schuetz JD, Watkins P. 6',7'-Dihydroxybergamottin in grapefruit juice and Seville orange juice: Effects on cyclosporine disposition, enterocyte CYP3A4, and P-glycoprotein Clinical Pharmacology and Therapeutics. 65: 237-244. PMID 10096255 DOI: 10.1016/S0009-9236(99)70102-5  0.92
1999 Thottassery JV, Sun D, Zambetti GP, Troutman A, Sukhatme VP, Schuetz EG, Schuetz JD. Sp1 and Egr-1 have opposing effects on the regulation of the rat Pgp2/mdr1b gene Journal of Biological Chemistry. 274: 3199-3206. PMID 9915860 DOI: 10.1074/jbc.274.5.3199  0.92
1998 Schuetz EG, Brimer C, Schuetz JD. Environmental xenobiotics and the antihormones cyproterone acetate and spironolactone use the nuclear hormone pregnenolone X receptor to activate the CYP3A23 hormone response element Molecular Pharmacology. 54: 1113-1117. PMID 9855641 DOI: 10.1124/MOL.54.6.1113  0.92
1998 Kostrubsky VE, Lewis LD, Strom SC, Wood SG, Schuetz EG, Schuetz JD, Sinclair PR, Wrighton SA, Sinclair JF. Induction of cytochrome P4503A by Taxol in primary cultures of human hepatocytes Archives of Biochemistry and Biophysics. 355: 131-136. PMID 9675018 DOI: 10.1006/abbi.1998.0730  0.92
1998 Fessing MY, Krynetski EY, Schuetz JD, Evans WE. Structural and functional analysis of the human TPMT gene promoter Advances in Experimental Medicine and Biology. 431: 315-318. PMID 9598082 DOI: 10.1007/978-1-4615-5381-6_62  0.92
1998 Schuetz EG, Yasuda K, Arimori K, Schuetz JD. Human MDR1 and mouse mdr1a P-glycoprotein alter the cellular retention and disposition of erythromycin, but not of retinoic acid or benzo(a)pyrene Archives of Biochemistry and Biophysics. 350: 340-347. PMID 9473310 DOI: 10.1006/abbi.1997.0537  0.92
1997 Thottassery JV, Zambettii GP, Arimori K, Schuetz EG, Schuetz JD. p53-dependent regulation of MDR1 gene expression causes selective resistance to chemotherapeutic agents Proceedings of the National Academy of Sciences of the United States of America. 94: 11037-11042. PMID 9380755 DOI: 10.1073/pnas.94.20.11037  0.92
1997 Galpin AJ, Schuetz JD, Masson E, Yanishevski Y, Synold TW, Barredo JC, Pui CH, Relling MV, Evans WE. Differences in folylpolyglutamate synthetase and dihydrofolate reductase expression in human B-lineage versus T-lineage leukemic lymphoblasts: Mechanisms for lineage differences in methotrexate polyglutamylation and cytotoxicity Molecular Pharmacology. 52: 155-163. PMID 9224825  0.92
1997 Furuya KN, Thottassery JV, Schuetz EG, Sharif M, Schuetz JD. Bromocriptine transcriptionally activates the multidrug resistance gene (pgp2/mdr1b) by a novel pathway Journal of Biological Chemistry. 272: 11518-11525. PMID 9111066 DOI: 10.1074/jbc.272.17.11518  0.92
1996 Strom SC, Pisarov LA, Dorko K, Thompson MT, Schuetz JD, Schuetz EG. Use of human hepatocytes to study P450 gene induction Methods in Enzymology. 272: 388-401. PMID 8791798 DOI: 10.1016/S0076-6879(96)72044-X  0.92
1996 Schuetz EG, Schinkel AH, Relling MV, Schuetz JD. P-glycoprotein: A major determinant of rifampicin-inducible expression of cytochrome P4503A in mice and humans Proceedings of the National Academy of Sciences of the United States of America. 93: 4001-4005. PMID 8633005 DOI: 10.1073/pnas.93.9.4001  0.92
1995 Schuetz JD, Guzelian PS. Isolation of CYP3A5P cDNA from human liver: a reflection of a novel cytochrome P-450 pseudogene Bba - Gene Structure and Expression. 1261: 161-165. PMID 7893755 DOI: 10.1016/0167-4781(95)00016-A  0.92
1995 Schuetz EG, Schuetz JD, Thompson MT, Fisher RA, Madariage JR, Strom SC. Phenotypic variability in induction of P-glycoprotein mRNA by aromatic hydrocarbons in primary human hepatocytes Molecular Carcinogenesis. 12: 61-65. PMID 7662117 DOI: 10.1002/mc.2940120202  0.92
1995 Schuetz JD, Strom SC, Schuetz EG. Induction of P-glycoprotein mRNA by protein synthesis inhibition is not controlled by a transcriptional repressor protein in rat and human liver cells Journal of Cellular Physiology. 165: 261-272. PMID 7593204 DOI: 10.1002/jcp.1041650207  0.92
1994 Schuetz JD, Guzelian PS, Beach DL. Selective expression of cytochrome P450 CYP3A mRNAs in embryonic and adult human liver Pharmacogenetics. 4: 11-20. PMID 8004129 DOI: 10.1097/00008571-199402000-00002  0.92
1994 Furuya KN, Gebhardt R, Schuetz EG, Schuetz JD. Isolation of rat pgp3 cDNA: evidence for gender and zonal regulation of expression in the liver Bba - Gene Structure and Expression. 1219: 636-644. PMID 7948020 DOI: 10.1016/0167-4781(94)90222-4  0.92
1993 Schuetz JD, Kauma S, Guzelian PS. Identification of the fetal liver cytochrome CYP3A7 in human endometrium and placenta Journal of Clinical Investigation. 92: 1018-1024. PMID 8349787 DOI: 10.1172/JCI116607  0.92
1992 Schuetz EG, Schuetz JD, Grogan WM, Naray-Fejes-Toth A, Fejes-Toth G, Raucy J, Guzelian P, Gionela K, Watlington CO. Expression of cytochrome P450 3A in amphibian, rat, and human kidney. Archives of Biochemistry and Biophysics. 294: 206-14. PMID 1550347 DOI: 10.1016/0003-9861(92)90159-T  0.92
1992 Spink DC, Eugster HP, Lincoln DW, Schuetz JD, Schuetz EG, Johnson JA, Kaminsky LS, Gierthy JF. 17 beta-estradiol hydroxylation catalyzed by human cytochrome P450 1A1: a comparison of the activities induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin in MCF-7 cells with those from heterologous expression of the cDNA. Archives of Biochemistry and Biophysics. 293: 342-8. PMID 1536570 DOI: 10.1016/0003-9861(92)90404-K  0.92
1992 Kolars JC, Schmiedlin-Ren P, Schuetz JD, Fang C, Watkins PB. Identification of rifampin-inducible P450IIIA4 (CYP3A4) in human small bowel enterocytes Journal of Clinical Investigation. 90: 1871-1878. PMID 1430211 DOI: 10.1172/JCI116064  0.92
1992 Burger HJ, Schuetz JD, Schuetz EG, Guzelian PS. Paradoxical transcriptional activation of rat liver cytochrome P-450 3A1 by dexamethasone and the antiglucocorticoid pregnenolone 16α-carbonitrile: Analysis by transient transfection into primary monolayer cultures of adult rat hepatocytes Proceedings of the National Academy of Sciences of the United States of America. 89: 2145-2149. PMID 1372436 DOI: 10.1073/pnas.89.6.2145  0.92
1990 Burger HJ, Schuetz EG, Schuetz JD, Guzelian PS. Divergent effects of cycloheximide on the induction of Class II and Class III cytochrome P450 mRNAs in cultures of adult rat hepatocytes Archives of Biochemistry and Biophysics. 281: 204-211. PMID 2393297 DOI: 10.1016/0003-9861(90)90433-Y  0.92
1989 Schuetz JD, Molowa DT, Guzelian PS. Characterization of a cDNA encoding a new member of the glucocorticoid-responsive cytochromes P450 in human liver Archives of Biochemistry and Biophysics. 274: 355-365. PMID 2802615 DOI: 10.1016/0003-9861(89)90449-9  0.92
1989 Matherly LH, Schuetz JD, Westin E, Goldman ID. A method for the synchronization of cultured cells with aphidicolin: Application to the large-scale synchronization of L1210 cells and the study of the cell cycle regulation of thymidylate synthase and dihydrofolate reductase Analytical Biochemistry. 182: 338-345. PMID 2514611 DOI: 10.1016/0003-2697(89)90605-2  0.92
1988 Schuetz JD, Wallace HJ, Diasio RB. DNA repair following incorporation of 5-fluorouracil into DNA of mouse bone marrow cells. Cancer Chemotherapy and Pharmacology. 21: 208-10. PMID 3359556 DOI: 10.1007/BF00262771  0.92
1985 Schuetz JD, Diasio RB. The effect of 5-fluorouracil on DNA chain elongation in intact bone marrow cells Biochemical and Biophysical Research Communications. 133: 361-367. PMID 4074377 DOI: 10.1016/0006-291X(85)91884-4  0.92
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