Martin W. Hetzer - Publications

Affiliations: 
Biology University of California, San Diego, La Jolla, CA 
Area:
Cell Biology

41/87 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Cho UH, Hetzer MW. Nuclear Periphery Takes Center Stage: The Role of Nuclear Pore Complexes in Cell Identity and Aging. Neuron. 106: 899-911. PMID 32553207 DOI: 10.1016/j.neuron.2020.05.031  1
2016 Hatch EM, Hetzer MW. Nuclear envelope rupture is induced by actin-based nucleus confinement. The Journal of Cell Biology. PMID 27697922 DOI: 10.1083/jcb.201603053  0.4
2015 Mertens J, Paquola AC, Ku M, Hatch E, Böhnke L, Ladjevardi S, McGrath S, Campbell B, Lee H, Herdy JR, Gonçalves JT, Toda T, Kim Y, Winkler J, Yao J, ... Hetzer MW, et al. Directly Reprogrammed Human Neurons Retain Aging-Associated Transcriptomic Signatures and Reveal Age-Related Nucleocytoplasmic Defects. Cell Stem Cell. PMID 26456686 DOI: 10.1016/J.Stem.2015.09.001  0.4
2015 Hatch EM, Hetzer MW. Linking Micronuclei to Chromosome Fragmentation. Cell. 161: 1502-4. PMID 26091034 DOI: 10.1016/j.cell.2015.06.005  0.4
2015 Hatch EM, Hetzer MW. Chromothripsis. Current Biology : Cb. 25: R397-9. PMID 25989073 DOI: 10.1016/j.cub.2015.02.033  0.4
2015 Ori A, Toyama BH, Harris MS, Bock T, Iskar M, Bork P, Ingolia NT, Hetzer MW, Beck M. Integrated Transcriptome and Proteome Analyses Reveal Organ-Specific Proteome Deterioration in Old Rats Cell Systems. 1: 224-237. DOI: 10.1016/j.cels.2015.08.012  0.4
2014 Hatch E, Hetzer M. Breaching the nuclear envelope in development and disease. The Journal of Cell Biology. 205: 133-41. PMID 24751535 DOI: 10.1083/jcb.201402003  0.4
2013 Toyama BH, Savas JN, Park SK, Harris MS, Ingolia NT, Yates JR, Hetzer MW. Identification of long-lived proteins reveals exceptional stability of essential cellular structures. Cell. 154: 971-82. PMID 23993091 DOI: 10.1016/J.Cell.2013.07.037  0.4
2013 Hatch EM, Fischer AH, Deerinck TJ, Hetzer MW. Catastrophic nuclear envelope collapse in cancer cell micronuclei. Cell. 154: 47-60. PMID 23827674 DOI: 10.1016/j.cell.2013.06.007  0.4
2013 Regner BM, Vu?ini? D, Domnisoru C, Bartol TM, Hetzer MW, Tartakovsky DM, Sejnowski TJ. Anomalous diffusion of single particles in cytoplasm. Biophysical Journal. 104: 1652-60. PMID 23601312 DOI: 10.1016/J.Bpj.2013.01.049  0.4
2013 Liang Y, Franks TM, Marchetto MC, Gage FH, Hetzer MW. Dynamic association of NUP98 with the human genome. Plos Genetics. 9: e1003308. PMID 23468646 DOI: 10.1371/Journal.Pgen.1003308  0.4
2013 Toyama BH, Hetzer MW. Protein homeostasis: live long, won't prosper. Nature Reviews. Molecular Cell Biology. 14: 55-61. PMID 23258296 DOI: 10.1038/Nrm3496  0.4
2013 Franks TM, Hetzer MW. The role of Nup98 in transcription regulation in healthy and diseased cells. Trends in Cell Biology. 23: 112-7. PMID 23246429 DOI: 10.1016/J.Tcb.2012.10.013  0.4
2012 Hatch EM, Hetzer MW. RNP export by nuclear envelope budding. Cell. 149: 733-5. PMID 22579277 DOI: 10.1016/j.cell.2012.04.018  0.4
2012 Vargas JD, Hatch EM, Anderson DJ, Hetzer MW. Transient nuclear envelope rupturing during interphase in human cancer cells. Nucleus (Austin, Tex.). 3: 88-100. PMID 22567193 DOI: 10.4161/nucl.18954  0.4
2012 Savas JN, Toyama BH, Xu T, Yates JR, Hetzer MW. Extremely long-lived nuclear pore proteins in the rat brain. Science (New York, N.Y.). 335: 942. PMID 22300851 DOI: 10.1126/Science.1217421  0.4
2012 D'Angelo MA, Gomez-Cavazos JS, Mei A, Lackner DH, Hetzer MW. A change in nuclear pore complex composition regulates cell differentiation. Developmental Cell. 22: 446-58. PMID 22264802 DOI: 10.1016/j.devcel.2011.11.021  0.4
2011 Talamas JA, Hetzer MW. POM121 and Sun1 play a role in early steps of interphase NPC assembly. The Journal of Cell Biology. 194: 27-37. PMID 21727197 DOI: 10.1083/jcb.201012154  0.4
2011 Hetzer M, Cavalli G. Eukaryotic cells. Current Opinion in Cell Biology. 23: 255-7. PMID 21592757 DOI: 10.1016/j.ceb.2011.04.013  0.4
2010 Capelson M, Doucet C, Hetzer MW. Nuclear pore complexes: guardians of the nuclear genome. Cold Spring Harbor Symposia On Quantitative Biology. 75: 585-97. PMID 21502404 DOI: 10.1101/Sqb.2010.75.059  0.4
2010 Doucet CM, Hetzer MW. Nuclear pore biogenesis into an intact nuclear envelope. Chromosoma. 119: 469-77. PMID 20721671 DOI: 10.1007/s00412-010-0289-2  0.4
2010 Doucet CM, Talamas JA, Hetzer MW. Cell cycle-dependent differences in nuclear pore complex assembly in metazoa. Cell. 141: 1030-41. PMID 20550937 DOI: 10.1016/j.cell.2010.04.036  0.4
2009 Hetzer MW, Wente SR. Border control at the nucleus: biogenesis and organization of the nuclear membrane and pore complexes. Developmental Cell. 17: 606-16. PMID 19922866 DOI: 10.1016/J.Devcel.2009.10.007  0.4
2009 Anderson DJ, Vargas JD, Hsiao JP, Hetzer MW. Recruitment of functionally distinct membrane proteins to chromatin mediates nuclear envelope formation in vivo. The Journal of Cell Biology. 186: 183-91. PMID 19620630 DOI: 10.1083/jcb.200901106  0.4
2009 Dawson TR, Lazarus MD, Hetzer MW, Wente SR. ER membrane-bending proteins are necessary for de novo nuclear pore formation. The Journal of Cell Biology. 184: 659-75. PMID 19273614 DOI: 10.1083/Jcb.200806174  0.4
2009 Vučinić D, Chi YM, Hetzer MW, Cauwenberghs G, Sejnowski TJ. CMOS descanning and acousto-optic scanning enable faster confocal imaging Optics Infobase Conference Papers. DOI: 10.1364/Ntm.2009.Nwa6  0.4
2009 Anderson DJ, Vargas JD, Hsiao JP, Hetzer MW. Recruitment of functionally distinct membrane proteins to chromatin mediates nuclear envelope formation in vivo (Journal of Cell Biology (2009) 186, 2 (183-191)) Journal of Cell Biology. 186: 929. DOI: 10.1083/jcb.20090110620090903c  0.4
2008 Kutay U, Hetzer MW. Reorganization of the nuclear envelope during open mitosis. Current Opinion in Cell Biology. 20: 669-77. PMID 18938243 DOI: 10.1016/J.Ceb.2008.09.010  0.4
2008 Anderson DJ, Hetzer MW. Reshaping of the endoplasmic reticulum limits the rate for nuclear envelope formation. The Journal of Cell Biology. 182: 911-24. PMID 18779370 DOI: 10.1083/jcb.200805140  0.4
2008 Anderson DJ, Hetzer MW. The life cycle of the metazoan nuclear envelope. Current Opinion in Cell Biology. 20: 386-92. PMID 18495454 DOI: 10.1016/j.ceb.2008.03.016  0.4
2008 Schulte R, Talamas J, Doucet C, Hetzer MW. Single bead affinity detection (SINBAD) for the analysis of protein-protein interactions. Plos One. 3: e2061. PMID 18446240 DOI: 10.1371/journal.pone.0002061  0.4
2008 Anderson DJ, Hetzer MW. Shaping the endoplasmic reticulum into the nuclear envelope. Journal of Cell Science. 121: 137-42. PMID 18187447 DOI: 10.1242/jcs.005777  0.4
2007 Anderson DJ, Hetzer MW. Nuclear envelope formation by chromatin-mediated reorganization of the endoplasmic reticulum. Nature Cell Biology. 9: 1160-6. PMID 17828249 DOI: 10.1038/ncb1636  0.4
2007 Franz C, Walczak R, Yavuz S, Santarella R, Gentzel M, Askjaer P, Galy V, Hetzer M, Mattaj IW, Antonin W. MEL-28/ELYS is required for the recruitment of nucleoporins to chromatin and postmitotic nuclear pore complex assembly. Embo Reports. 8: 165-72. PMID 17235358 DOI: 10.1038/sj.embor.7400889  0.68
2006 D'Angelo MA, Anderson DJ, Richard E, Hetzer MW. Nuclear pores form de novo from both sides of the nuclear envelope. Science (New York, N.Y.). 312: 440-3. PMID 16627745 DOI: 10.1126/science.1124196  0.4
2006 Harris JR, Almouzni G, Kirschner D, Dimitrova D, Nickerson JA, Underwood J, Wagner S, Korbei B, Foisner R, Walther TC, Hetzer M, Peters R, Walev I, de Kroon AIPM, Staffhorst RWHM, et al. In Vitro Techniques Cell Biology Protocols. 201-378. DOI: 10.1002/0470033487.ch6  0.4
2005 Hetzer MW, Walther TC, Mattaj IW. Pushing the envelope: structure, function, and dynamics of the nuclear periphery. Annual Review of Cell and Developmental Biology. 21: 347-80. PMID 16212499 DOI: 10.1146/annurev.cellbio.21.090704.151152  0.68
2003 Walther TC, Askjaer P, Gentzel M, Habermann A, Griffiths G, Wilm M, Mattaj IW, Hetzer M. RanGTP mediates nuclear pore complex assembly. Nature. 424: 689-94. PMID 12894213 DOI: 10.1038/nature01898  0.68
2003 Walther TC, Alves A, Pickersgill H, Loïodice I, Hetzer M, Galy V, Hülsmann BB, Köcher T, Wilm M, Allen T, Mattaj IW, Doye V. The conserved Nup107-160 complex is critical for nuclear pore complex assembly. Cell. 113: 195-206. PMID 12705868 DOI: 10.1016/S0092-8674(03)00235-6  0.68
2002 Bilbao-Cortés D, Hetzer M, Längst G, Becker PB, Mattaj IW. Ran binds to chromatin by two distinct mechanisms. Current Biology : Cb. 12: 1151-6. PMID 12121625 DOI: 10.1016/S0960-9822(02)00927-2  0.68
2002 Hetzer M, Gruss OJ, Mattaj IW. The Ran GTPase as a marker of chromosome position in spindle formation and nuclear envelope assembly. Nature Cell Biology. 4: E177-84. PMID 12105431 DOI: 10.1038/ncb0702-e177  0.68
Low-probability matches
2000 Hetzer M, Mattaj IW. An ATP-dependent, Ran-independent mechanism for nuclear import of the U1A and U2B" spliceosome proteins. The Journal of Cell Biology. 148: 293-303. PMID 10648562 DOI: 10.1083/JCB.148.2.293  0.28
2000 Hetzer M, Bilbao-Cortés D, Walther TC, Gruss OJ, Mattaj IW. GTP hydrolysis by Ran is required for nuclear envelope assembly. Molecular Cell. 5: 1013-24. PMID 10911995 DOI: 10.1016/S1097-2765(00)80266-X  0.24
1998 Palacios I, Hetzer M, Adam SA, Mattaj IW. Nuclear import of U snRNPs requires importin beta. The Embo Journal. 16: 6783-92. PMID 9362492 DOI: 10.1093/EMBOJ/16.22.6783  0.16
2019 Buchwalter A, Schulte R, Tsai H, Capitanio J, Hetzer M. Selective clearance of the inner nuclear membrane protein emerin by vesicular transport during ER stress. Elife. 8. PMID 31599721 DOI: 10.7554/eLife.49796  0.08
2018 Toyama BH, Arrojo E Drigo R, Lev-Ram V, Ramachandra R, Deerinck TJ, Lechene C, Ellisman MH, Hetzer MW. Visualization of long-lived proteins reveals age mosaicism within nuclei of postmitotic cells. The Journal of Cell Biology. PMID 30552100 DOI: 10.1083/Jcb.201809123  0.08
2018 E DRIGO RA, TOYAMA BH, TYAGI S, LEV-RAM V, DEERINCK TJ, BUSHONG EA, RAMACHANDRA R, LECHENE C, ELLISMAN MH, HETZER M. Longevity of Beta Cells and Protein Complexes Revealed by Isotope Imaging Diabetes. 67: 307-LB. DOI: 10.2337/Db18-307-Lb  0.08
2014 Hetzer M, Schmidt BVKJ, Barner-Kowollik C, Ritter H. Supramolecular polymer networks of building blocks prepared via RAFT polymerization Polymer Chemistry. 5: 2142-2152. DOI: 10.1039/c3py01624b  0.08
2014 Schmidt BVKJ, Hetzer M, Ritter H, Barner-Kowollik C. Complex macromolecular architecture design via cyclodextrin host/guest complexes Progress in Polymer Science. 39: 235-249. DOI: 10.1016/j.progpolymsci.2013.09.006  0.08
2013 Schmidt BV, Hetzer M, Ritter H, Barner-Kowollik C. Modulation of the thermoresponsive behavior of poly(N,N-diethylacrylamide) via cyclodextrin host/guest interactions. Macromolecular Rapid Communications. 34: 1306-11. PMID 23881563 DOI: 10.1002/marc.201300478  0.08
2013 Schmidt BVKJ, Hetzer M, Ritter H, Barner-Kowollik C. UV light and temperature responsive supramolecular ABA triblock copolymers via reversible cyclodextrin complexation Macromolecules. 46: 1054-1065. DOI: 10.1021/ma302386w  0.08
2013 Hetzer M, Fleischmann C, Schmidt BVKJ, Barner-Kowollik C, Ritter H. Visual recognition of supramolecular graft polymer formation via phenolphthalein-cyclodextrin association Polymer (United Kingdom). 54: 5141-5147. DOI: 10.1016/j.polymer.2013.07.031  0.08
2013 Hetzer M, Schmidt BVKJ, Barner-Kowollik C, Ritter H. Limitations of cyclodextrin-mediated RAFT homopolymerization and block copolymer formation Journal of Polymer Science, Part a: Polymer Chemistry. 51: 2504-2517. DOI: 10.1002/pola.26644  0.08
2012 Schmidt BVKJ, Rudolph T, Hetzer M, Ritter H, Schacher FH, Barner-Kowollik C. Supramolecular three-armed star polymers via cyclodextrin host-guest self-assembly Polymer Chemistry. 3: 3139-3145. DOI: 10.1039/c2py20293j  0.08
2012 Schmidt BVKJ, Hetzer M, Ritter H, Barner-Kowollik C. Miktoarm star polymers via cyclodextrin-driven supramolecular self-assembly Polymer Chemistry. 3: 3064-3067. DOI: 10.1039/c2py20214j  0.08
2011 Schmidt BVKJ, Hetzer M, Ritter H, Barner-Kowollik C. Cyclodextrin-Complexed RAFT Agents for the Ambient Temperature Aqueous Living/Controlled Radical Polymerization of Acrylamido Monomers Macromolecules. 44: 7220-7232. DOI: 10.1021/MA2011969  0.08
2020 Bersini S, Schulte R, Huang L, Tsai H, Hetzer MW. Direct reprogramming of human smooth muscle and vascular endothelial cells reveals defects associated with aging and Hutchinson-Gilford progeria syndrome. Elife. 9. PMID 32896271 DOI: 10.7554/eLife.54383  0.01
2020 Kang H, Shokhirev MN, Xu Z, Chandran S, Dixon JR, Hetzer MW. Dynamic regulation of histone modifications and long-range chromosomal interactions during postmitotic transcriptional reactivation. Genes & Development. PMID 32499403 DOI: 10.1101/Gad.335794.119  0.01
2020 Bersini S, Arrojo E Drigo R, Huang L, Shokhirev MN, Hetzer MW. Transcriptional and Functional Changes of the Human Microvasculature during Physiological Aging and Alzheimer Disease. Advanced Biosystems. 4: e2000044. PMID 32402127 DOI: 10.1002/adbi.202000044  0.01
2020 Bersini S, Lytle NK, Schulte R, Huang L, Wahl GM, Hetzer MW. Nup93 regulates breast tumor growth by modulating cell proliferation and actin cytoskeleton remodeling. Life Science Alliance. 3. PMID 31959624 DOI: 10.26508/lsa.201900623  0.01
2019 Arrojo E Drigo R, Lev-Ram V, Tyagi S, Ramachandra R, Deerinck T, Bushong E, Phan S, Orphan V, Lechene C, Ellisman MH, Hetzer MW. Age Mosaicism across Multiple Scales in Adult Tissues. Cell Metabolism. PMID 31178361 DOI: 10.1016/J.Cmet.2019.05.010  0.01
2018 Fleischer JG, Schulte R, Tsai HH, Tyagi S, Ibarra A, Shokhirev MN, Huang L, Hetzer MW, Navlakha S. Predicting age from the transcriptome of human dermal fibroblasts. Genome Biology. 19: 221. PMID 30567591 DOI: 10.1186/S13059-018-1599-6  0.01
2018 Buchwalter A, Kaneshiro JM, Hetzer MW. Coaching from the sidelines: the nuclear periphery in genome regulation. Nature Reviews. Genetics. PMID 30356165 DOI: 10.1038/s41576-018-0063-5  0.01
2018 McCloskey A, Ibarra A, Hetzer MW. Tpr regulates the total number of nuclear pore complexes per cell nucleus. Genes & Development. 32: 1321-1331. PMID 30228202 DOI: 10.1101/gad.315523.118  0.01
2017 van de Ven RAH, de Groot JS, Park D, van Domselaar R, de Jong D, Szuhai K, van der Wall E, Rueda OM, Ali HR, Caldas C, van Diest PJ, Hetzer MW, Sahai E, Derksen PWB. Corrigendum: p120-catenin prevents multinucleation through control of MKLP1-dependent RhoA activity during cytokinesis. Nature Communications. 8: 16030. PMID 31305775 DOI: 10.1038/ncomms16030  0.01
2017 Franks TM, McCloskey A, Shokirev M, Benner C, Rathore A, Hetzer MW. Nup98 recruits the Wdr82-Set1A/COMPASS complex to promoters to regulate H3K4 trimethylation in hematopoietic progenitor cells. Genes & Development. 31: 2222-2234. PMID 29269482 DOI: 10.1101/Gad.306753.117  0.01
2017 Toda T, Hsu JY, Linker SB, Hu L, Schafer ST, Mertens J, Jacinto FV, Hetzer MW, Gage FH. Nup153 Interacts with Sox2 to Enable Bimodal Gene Regulation and Maintenance of Neural Progenitor Cells. Cell Stem Cell. PMID 28919367 DOI: 10.1016/j.stem.2017.08.012  0.01
2017 Buchwalter A, Hetzer MW. Nucleolar expansion and elevated protein translation in premature aging. Nature Communications. 8: 328. PMID 28855503 DOI: 10.1038/s41467-017-00322-z  0.01
2017 Franks TM, Benner C, Narvaiza I, Marchetto MCN, Young JM, Malik HS, Gage FH, Hetzer MW. Corrigendum: Evolution of a transcriptional regulator from a transmembrane nucleoporin. Genes & Development. 31: 845. PMID 28512238 DOI: 10.1101/Gad.300699.117  0.01
2016 van de Ven RA, de Groot JS, Park D, van Domselaar R, de Jong D, Szuhai K, van der Wall E, Rueda OM, Ali HR, Caldas C, van Diest PJ, Hetzer MW, Sahai E, Derksen PW. p120-catenin prevents multinucleation through control of MKLP1-dependent RhoA activity during cytokinesis. Nature Communications. 7: 13874. PMID 28004812 DOI: 10.1038/ncomms13874  0.01
2016 Ibarra A, Benner C, Tyagi S, Cool J, Hetzer MW. Nucleoporin-mediated regulation of cell identity genes. Genes & Development. PMID 27807035 DOI: 10.1101/Gad.287417.116  0.01
2016 Franks TM, Benner C, Narvaiza I, Marchetto MC, Young JM, Malik HS, Gage FH, Hetzer MW. Evolution of a transcriptional regulator from a transmembrane nucleoporin. Genes & Development. PMID 27198230 DOI: 10.1101/Gad.280941.116  0.01
2015 Ori A, Toyama BH, Harris MS, Bock T, Iskar M, Bork P, Ingolia NT, Hetzer MW, Beck M. Integrated Transcriptome and Proteome Analyses Reveal Organ-Specific Proteome Deterioration in Old Rats. Cell Systems. 1: 224-237. PMID 27135913 DOI: 10.1016/J.Cels.2015.08.012  0.01
2015 Jacinto FV, Benner C, Hetzer MW. The nucleoporin Nup153 regulates embryonic stem cell pluripotency through gene silencing. Genes & Development. 29: 1224-38. PMID 26080816 DOI: 10.1101/Gad.260919.115  0.01
2015 Gomez-Cavazos JS, Hetzer MW. The nucleoporin gp210/Nup210 controls muscle differentiation by regulating nuclear envelope/ER homeostasis. The Journal of Cell Biology. 208: 671-81. PMID 25778917 DOI: 10.1083/jcb.201410047  0.01
2015 Ibarra A, Hetzer MW. Nuclear pore proteins and the control of genome functions. Genes & Development. 29: 337-49. PMID 25691464 DOI: 10.1101/gad.256495.114  0.01
2014 Buchwalter AL, Liang Y, Hetzer MW. Nup50 is required for cell differentiation and exhibits transcription-dependent dynamics. Molecular Biology of the Cell. 25: 2472-84. PMID 24943837 DOI: 10.1091/mbc.E14-04-0865  0.01
2014 Buchwalter A, Hetzer MW. Nuclear pores set the speed limit for mitosis. Cell. 156: 868-9. PMID 24581486 DOI: 10.1016/j.cell.2014.02.004  0.01
2012 Gomez-Cavazos JS, Hetzer MW. Outfits for different occasions: tissue-specific roles of Nuclear Envelope proteins. Current Opinion in Cell Biology. 24: 775-83. PMID 22995343 DOI: 10.1016/j.ceb.2012.08.008  0.01
2011 Liang Y, Hetzer MW. Functional interactions between nucleoporins and chromatin. Current Opinion in Cell Biology. 23: 65-70. PMID 21030234 DOI: 10.1016/j.ceb.2010.09.008  0.01
2010 Hetzer MW. The role of the nuclear pore complex in aging of post-mitotic cells. Aging. 2: 74-5. PMID 20354266 DOI: 10.18632/aging.100125  0.01
2010 Hetzer MW. The nuclear envelope. Cold Spring Harbor Perspectives in Biology. 2: a000539. PMID 20300205 DOI: 10.1101/cshperspect.a000539  0.01
2010 Capelson M, Liang Y, Schulte R, Mair W, Wagner U, Hetzer MW. Chromatin-bound nuclear pore components regulate gene expression in higher eukaryotes. Cell. 140: 372-83. PMID 20144761 DOI: 10.1016/J.Cell.2009.12.054  0.01
2009 Capelson M, Hetzer MW. The role of nuclear pores in gene regulation, development and disease. Embo Reports. 10: 697-705. PMID 19543230 DOI: 10.1038/Embor.2009.147  0.01
2009 D'Angelo MA, Raices M, Panowski SH, Hetzer MW. Age-dependent deterioration of nuclear pore complexes causes a loss of nuclear integrity in postmitotic cells. Cell. 136: 284-95. PMID 19167330 DOI: 10.1016/j.cell.2008.11.037  0.01
2008 D'Angelo MA, Hetzer MW. Structure, dynamics and function of nuclear pore complexes. Trends in Cell Biology. 18: 456-66. PMID 18786826 DOI: 10.1016/j.tcb.2008.07.009  0.01
2006 D'Angelo MA, Hetzer MW. The role of the nuclear envelope in cellular organization. Cellular and Molecular Life Sciences : Cmls. 63: 316-32. PMID 16389459 DOI: 10.1007/s00018-005-5361-3  0.01
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