Doris A. Stoffers - Publications

Affiliations: 
University of Pennsylvania, Philadelphia, PA, United States 
Area:
Molecular Biology, Genetics, Cell Biology, Animal Physiology Biology

63 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Good AL, Haemmerle MW, Oguh AU, Doliba NM, Stoffers DA. Metabolic stress activates an ERK/hnRNPK/DDX3X pathway in pancreatic β cells. Molecular Metabolism. PMID 31178390 DOI: 10.1016/j.molmet.2019.05.009  0.4
2019 Good AL, Cannon CE, Haemmerle MW, Yang J, Stanescu DE, Doliba NM, Birnbaum MJ, Stoffers DA. JUND regulates pancreatic β cell survival during metabolic stress. Molecular Metabolism. PMID 31023625 DOI: 10.1016/j.molmet.2019.04.007  1
2019 Poitout V, Satin LS, Kahn SE, Stoffers DA, Marchetti P, Gannon M, Verchere CB, Herold KC, Myers MG, Marshall SM. A call for improved reporting of human islet characteristics in research articles. Diabetologia. 62: 209-211. PMID 30547229 DOI: 10.1007/s00125-018-4784-y  1
2018 Poitout V, Satin LS, Kahn SE, Stoffers DA, Marchetti P, Gannon M, Verchere CB, Herold KC, Myers MG, Marshall SM. A Call for Improved Reporting of Human Islet Characteristics in Research Articles. Diabetes. PMID 30552106 DOI: 10.2337/dbi18-0055  1
2018 Juliana CA, Yang J, Cannon CE, Good AL, Haemmerle MW, Stoffers DA. A PDX1-ATF transcriptional complex governs β cell survival during stress. Molecular Metabolism. PMID 30174228 DOI: 10.1016/j.molmet.2018.07.007  1
2017 Kropp PA, Dunn JC, Carboneau BA, Stoffers DA, Gannon M. Cooperative function of Pdx1 and Oc1 in multipotent pancreatic progenitors impacts postnatal islet maturation and adaptability. American Journal of Physiology. Endocrinology and Metabolism. PMID 29351489 DOI: 10.1152/ajpendo.00260.2017  1
2017 Burmeister MA, Brown JD, Ayala JE, Stoffers DA, Sandoval DA, Seeley RJ, Ayala JE. The Glucagon-Like Peptide-1 Receptor in the Ventromedial Hypothalamus Reduces Short-Term Food Intake in Male Mice by Regulating Nutrient Sensor Activity. American Journal of Physiology. Endocrinology and Metabolism. ajpendo.00113.2017. PMID 28811293 DOI: 10.1152/ajpendo.00113.2017  1
2017 Rozo AV, Babu DA, Suen PA, Groff DN, Seeley RJ, Simmons RA, Seale P, Ahima RS, Stoffers DA. Neonatal GLP1R activation limits adult adiposity by durably altering hypothalamic architecture. Molecular Metabolism. 6: 748-759. PMID 28702330 DOI: 10.1016/j.molmet.2017.05.006  1
2017 Remsberg JR, Ediger BN, Ho WY, Damle M, Li Z, Teng C, Lanzillotta C, Stoffers DA, Lazar MA. Deletion of histone deacetylase 3 in adult beta cells improves glucose tolerance via increased insulin secretion. Molecular Metabolism. 6: 30-37. PMID 28123935 DOI: 10.1016/j.molmet.2016.11.007  1
2017 Juliana CA, Yang J, Rozo AV, Good A, Groff DN, Wang SZ, Green MR, Stoffers DA. ATF5 regulates β-cell survival during stress. Proceedings of the National Academy of Sciences of the United States of America. PMID 28115692 DOI: 10.1073/pnas.1620705114  0.01
2016 Stanescu DE, Yu R, Won KJ, Stoffers DA. Single cell transcriptomic profiling of mouse pancreatic progenitors. Physiological Genomics. physiolgenomics.0011. PMID 28011883 DOI: 10.1152/physiolgenomics.00114.2016  1
2016 Loyd C, Liu Y, Kim T, Holleman C, Galloway J, Bethea M, Ediger BN, Tang Y, Swain TA, Stoffers DA, Rowe GC, Young M, Steele C, Habegger KM, Hunter CS. Ldb1 Regulates Energy Homeostasis During Diet-Induced Obesity. Endocrinology. en20161791. PMID 28009534 DOI: 10.1210/en.2016-1791  1
2016 Ediger BN, Lim HW, Juliana C, Groff DN, Williams LT, Dominguez G, Liu JH, Taylor BL, Walp ER, Kameswaran V, Yang J, Liu C, Hunter CS, Kaestner KH, Naji A, ... ... Stoffers DA, et al. LIM domain-binding 1 maintains the terminally differentiated state of pancreatic β cells. The Journal of Clinical Investigation. PMID 27941246 DOI: 10.1172/JCI88016  1
2016 Burmeister MA, Ayala JE, Smouse H, Landivar-Rocha A, Brown JD, Drucker DJ, Stoffers DA, Sandoval DA, Seeley RJ, Ayala JE. "The Hypothalamic Glucagon-Like Peptide-1 (GLP-1) Receptor (GLP-1R) is Sufficient but Not Necessary for the Regulation of Energy Balance and Glucose Homeostasis in Mice". Diabetes. PMID 27908915 DOI: 10.2337/db16-1102  1
2016 Henley KD, Stanescu DE, Kropp PA, Wright CV, Won KJ, Stoffers DA, Gannon M. Threshold-Dependent Cooperativity of Pdx1 and Oc1 in Pancreatic Progenitors Establishes Competency for Endocrine Differentiation and β-Cell Function. Cell Reports. PMID 27292642 DOI: 10.1016/j.celrep.2016.05.040  1
2015 Soleimanpour SA, Ferrari AM, Raum JC, Groff DN, Yang J, Kaufman BA, Stoffers DA. Diabetes susceptibility genes Pdx1 and Clec16a function in a pathway regulating mitophagy in β-cells. Diabetes. PMID 26085571 DOI: 10.2337/db15-0376  1
2015 Raum JC, Soleimanpour SA, Groff DN, Coré N, Fasano L, Garratt AN, Dai C, Powers AC, Stoffers DA. Tshz1 Regulates Pancreatic β-Cell Maturation. Diabetes. 64: 2905-14. PMID 25918232 DOI: 10.2337/db14-1443  1
2015 Wang A, Yue F, Li Y, Xie R, Harper T, Patel NA, Muth K, Palmer J, Qiu Y, Wang J, Lam DK, Raum JC, Stoffers DA, Ren B, Sander M. Epigenetic priming of enhancers predicts developmental competence of hESC-derived endodermal lineage intermediates. Cell Stem Cell. 16: 386-99. PMID 25842977 DOI: 10.1016/j.stem.2015.02.013  1
2014 Cannon CE, Titchenell PM, Groff DN, El Ouaamari A, Kulkarni RN, Birnbaum MJ, Stoffers DA. The Polycomb protein, Bmi1, regulates insulin sensitivity. Molecular Metabolism. 3: 794-802. PMID 25379404 DOI: 10.1016/j.molmet.2014.08.002  1
2014 Ussher JR, Baggio LL, Campbell JE, Mulvihill EE, Kim M, Kabir MG, Cao X, Baranek BM, Stoffers DA, Seeley RJ, Drucker DJ. Inactivation of the cardiomyocyte glucagon-like peptide-1 receptor (GLP-1R) unmasks cardiomyocyte-independent GLP-1R-mediated cardioprotection. Molecular Metabolism. 3: 507-17. PMID 25061556 DOI: 10.1016/j.molmet.2014.04.009  1
2014 Ediger BN, Du A, Liu J, Hunter CS, Walp ER, Schug J, Kaestner KH, Stein R, Stoffers DA, May CL. Islet-1 Is essential for pancreatic β-cell function. Diabetes. 63: 4206-17. PMID 25028525 DOI: 10.2337/db14-0096  1
2014 Soleimanpour SA, Gupta A, Bakay M, Ferrari AM, Groff DN, Fadista J, Spruce LA, Kushner JA, Groop L, Seeholzer SH, Kaufman BA, Hakonarson H, Stoffers DA. The diabetes susceptibility gene Clec16a regulates mitophagy. Cell. 157: 1577-90. PMID 24949970 DOI: 10.1016/j.cell.2014.05.016  1
2014 Liew CW, Assmann A, Templin AT, Raum JC, Lipson KL, Rajan S, Qiang G, Hu J, Kawamori D, Lindberg I, Philipson LH, Sonenberg N, Goldfine AB, Stoffers DA, Mirmira RG, et al. Insulin regulates carboxypeptidase E by modulating translation initiation scaffolding protein eIF4G1 in pancreatic β cells. Proceedings of the National Academy of Sciences of the United States of America. 111: E2319-28. PMID 24843127 DOI: 10.1073/pnas.1323066111  1
2014 Smith EP, An Z, Wagner C, Lewis AG, Cohen EB, Li B, Mahbod P, Sandoval D, Perez-Tilve D, Tamarina N, Philipson LH, Stoffers DA, Seeley RJ, D'Alessio DA. The role of β cell glucagon-like peptide-1 signaling in glucose regulation and response to diabetes drugs. Cell Metabolism. 19: 1050-7. PMID 24836562 DOI: 10.1016/j.cmet.2014.04.005  1
2014 Gao T, McKenna B, Li C, Reichert M, Nguyen J, Singh T, Yang C, Pannikar A, Doliba N, Zhang T, Stoffers DA, Edlund H, Matschinsky F, Stein R, Stanger BZ. Pdx1 maintains β cell identity and function by repressing an α cell program. Cell Metabolism. 19: 259-71. PMID 24506867 DOI: 10.1016/j.cmet.2013.12.002  1
2014 Baeyens L, Lemper M, Leuckx G, De Groef S, Bonfanti P, Stangé G, Shemer R, Nord C, Scheel DW, Pan FC, Ahlgren U, Gu G, Stoffers DA, Dor Y, Ferrer J, et al. Transient cytokine treatment induces acinar cell reprogramming and regenerates functional beta cell mass in diabetic mice. Nature Biotechnology. 32: 76-83. PMID 24240391 DOI: 10.1038/nbt.2747  1
2013 Soleimanpour SA, Stoffers DA. The pancreatic β cell and type 1 diabetes: innocent bystander or active participant? Trends in Endocrinology and Metabolism: Tem. 24: 324-31. PMID 23647931 DOI: 10.1016/j.tem.2013.03.005  1
2013 Wang Y, Liu J, Liu C, Naji A, Stoffers DA. MicroRNA-7 regulates the mTOR pathway and proliferation in adult pancreatic β-cells. Diabetes. 62: 887-95. PMID 23223022 DOI: 10.2337/db12-0451  1
2012 Khoo C, Yang J, Weinrott SA, Kaestner KH, Naji A, Schug J, Stoffers DA. Research resource: the pdx1 cistrome of pancreatic islets. Molecular Endocrinology (Baltimore, Md.). 26: 521-33. PMID 22322596 DOI: 10.1210/me.2011-1231  1
2011 Khoo C, Yang J, Rajpal G, Wang Y, Liu J, Arvan P, Stoffers DA. Endoplasmic reticulum oxidoreductin-1-like β (ERO1lβ) regulates susceptibility to endoplasmic reticulum stress and is induced by insulin flux in β-cells. Endocrinology. 152: 2599-608. PMID 21540283 DOI: 10.1210/en.2010-1420  1
2011 Pinney SE, Oliver-Krasinski J, Ernst L, Hughes N, Patel P, Stoffers DA, Russo P, De León DD. Neonatal diabetes and congenital malabsorptive diarrhea attributable to a novel mutation in the human neurogenin-3 gene coding sequence. The Journal of Clinical Endocrinology and Metabolism. 96: 1960-5. PMID 21490072 DOI: 10.1210/jc.2011-0029  1
2010 Yang Y, Gurung B, Wu T, Wang H, Stoffers DA, Hua X. Reversal of preexisting hyperglycemia in diabetic mice by acute deletion of the Men1 gene. Proceedings of the National Academy of Sciences of the United States of America. 107: 20358-63. PMID 21059956 DOI: 10.1073/pnas.1012257107  1
2010 Liu J, Wang Y, Birnbaum MJ, Stoffers DA. Three-amino-acid-loop-extension homeodomain factor Meis3 regulates cell survival via PDK1. Proceedings of the National Academy of Sciences of the United States of America. 107: 20494-9. PMID 21059917 DOI: 10.1073/pnas.1007001107  1
2010 Soleimanpour SA, Crutchlow MF, Ferrari AM, Raum JC, Groff DN, Rankin MM, Liu C, De León DD, Naji A, Kushner JA, Stoffers DA. Calcineurin signaling regulates human islet {beta}-cell survival. The Journal of Biological Chemistry. 285: 40050-9. PMID 20943662 DOI: 10.1074/jbc.M110.154955  1
2010 Claiborn KC, Sachdeva MM, Cannon CE, Groff DN, Singer JD, Stoffers DA. Pcif1 modulates Pdx1 protein stability and pancreatic β cell function and survival in mice. The Journal of Clinical Investigation. 120: 3713-21. PMID 20811152 DOI: 10.1172/JCI40440  1
2010 Nicolino M, Claiborn KC, Senée V, Boland A, Stoffers DA, Julier C. A novel hypomorphic PDX1 mutation responsible for permanent neonatal diabetes with subclinical exocrine deficiency. Diabetes. 59: 733-40. PMID 20009086 DOI: 10.2337/db09-1284  1
2009 Sachdeva MM, Claiborn KC, Khoo C, Yang J, Groff DN, Mirmira RG, Stoffers DA. Pdx1 (MODY4) regulates pancreatic beta cell susceptibility to ER stress. Proceedings of the National Academy of Sciences of the United States of America. 106: 19090-5. PMID 19855005 DOI: 10.1073/pnas.0904849106  1
2009 Raab EL, Vuguin PM, Stoffers DA, Simmons RA. Neonatal exendin-4 treatment reduces oxidative stress and prevents hepatic insulin resistance in intrauterine growth-retarded rats. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 297: R1785-94. PMID 19846744 DOI: 10.1152/ajpregu.00519.2009  1
2009 Oliver-Krasinski JM, Kasner MT, Yang J, Crutchlow MF, Rustgi AK, Kaestner KH, Stoffers DA. The diabetes gene Pdx1 regulates the transcriptional network of pancreatic endocrine progenitor cells in mice. The Journal of Clinical Investigation. 119: 1888-98. PMID 19487809 DOI: 10.1172/JCI37028  1
2009 Ham JN, Crutchlow MF, Desai BM, Simmons RA, Stoffers DA. Exendin-4 normalizes islet vascularity in intrauterine growth restricted rats: potential role of VEGF. Pediatric Research. 66: 42-6. PMID 19287346 DOI: 10.1203/PDR.0b013e3181a282a5  1
2009 Sachdeva MM, Stoffers DA. Minireview: Meeting the demand for insulin: molecular mechanisms of adaptive postnatal beta-cell mass expansion. Molecular Endocrinology (Baltimore, Md.). 23: 747-58. PMID 19196831 DOI: 10.1210/me.2008-0400  1
2008 Habbe N, Shi G, Meguid RA, Fendrich V, Esni F, Chen H, Feldmann G, Stoffers DA, Konieczny SF, Leach SD, Maitra A. Spontaneous induction of murine pancreatic intraepithelial neoplasia (mPanIN) by acinar cell targeting of oncogenic Kras in adult mice. Proceedings of the National Academy of Sciences of the United States of America. 105: 18913-8. PMID 19028870 DOI: 10.1073/pnas.0810097105  1
2008 Claiborn KC, Stoffers DA. Toward a cell-based cure for diabetes: advances in production and transplant of beta cells. The Mount Sinai Journal of Medicine, New York. 75: 362-71. PMID 18729181 DOI: 10.1002/msj.20058  1
2008 Oliver-Krasinski JM, Stoffers DA. On the origin of the beta cell. Genes & Development. 22: 1998-2021. PMID 18676806 DOI: 10.1101/gad.1670808  1
2008 De León DD, Li C, Delson MI, Matschinsky FM, Stanley CA, Stoffers DA. Exendin-(9-39) corrects fasting hypoglycemia in SUR-1-/- mice by lowering cAMP in pancreatic beta-cells and inhibiting insulin secretion. The Journal of Biological Chemistry. 283: 25786-93. PMID 18635551 DOI: 10.1074/jbc.M804372200  1
2008 Park JH, Stoffers DA, Nicholls RD, Simmons RA. Development of type 2 diabetes following intrauterine growth retardation in rats is associated with progressive epigenetic silencing of Pdx1. The Journal of Clinical Investigation. 118: 2316-24. PMID 18464933 DOI: 10.1172/JCI33655  1
2007 Crutchlow MF, Stoffers DA. Maximizing endogenous β-cell regeneration. Current Opinion in Organ Transplantation. 12: 55-62. PMID 27792090 DOI: 10.1097/MOT.0b013e328012b281  1
2007 Desai BM, Oliver-Krasinski J, De Leon DD, Farzad C, Hong N, Leach SD, Stoffers DA. Preexisting pancreatic acinar cells contribute to acinar cell, but not islet beta cell, regeneration. The Journal of Clinical Investigation. 117: 971-7. PMID 17404620 DOI: 10.1172/JCI29988  1
2006 Liu A, Oliver-Krasinski J, Stoffers DA. Two conserved domains in PCIF1 mediate interaction with pancreatic transcription factor PDX-1. Febs Letters. 580: 6701-6. PMID 17126328 DOI: 10.1016/j.febslet.2006.11.021  1
2006 Deramaudt TB, Sachdeva MM, Wescott MP, Chen Y, Stoffers DA, Rustgi AK. The PDX1 homeodomain transcription factor negatively regulates the pancreatic ductal cell-specific keratin 19 promoter. The Journal of Biological Chemistry. 281: 38385-95. PMID 17056599 DOI: 10.1074/jbc.M605891200  1
2006 De León DD, Farzad C, Crutchlow MF, Brestelli J, Tobias J, Kaestner KH, Stoffers DA. Identification of transcriptional targets during pancreatic growth after partial pancreatectomy and exendin-4 treatment. Physiological Genomics. 24: 133-43. PMID 16410542 DOI: 10.1152/physiolgenomics.00156.2005  1
2006 Lee CS, De León DD, Kaestner KH, Stoffers DA. Regeneration of pancreatic islets after partial pancreatectomy in mice does not involve the reactivation of neurogenin-3. Diabetes. 55: 269-72. PMID 16361411  1
2006 De León DD, Crutchlow MF, Ham JY, Stoffers DA. Role of glucagon-like peptide-1 in the pathogenesis and treatment of diabetes mellitus. The International Journal of Biochemistry & Cell Biology. 38: 845-59. PMID 16202636 DOI: 10.1016/j.biocel.2005.07.011  1
2005 Means AL, Meszoely IM, Suzuki K, Miyamoto Y, Rustgi AK, Coffey RJ, Wright CV, Stoffers DA, Leach SD. Pancreatic epithelial plasticity mediated by acinar cell transdifferentiation and generation of nestin-positive intermediates. Development (Cambridge, England). 132: 3767-76. PMID 16020518 DOI: 10.1242/dev.01925  1
2004 Schreiber FS, Deramaudt TB, Brunner TB, Boretti MI, Gooch KJ, Stoffers DA, Bernhard EJ, Rustgi AK. Successful growth and characterization of mouse pancreatic ductal cells: functional properties of the Ki-RAS(G12V) oncogene. Gastroenterology. 127: 250-60. PMID 15236190 DOI: 10.1053/j.gastro.2004.03.058  1
2004 Liu A, Desai BM, Stoffers DA. Identification of PCIF1, a POZ domain protein that inhibits PDX-1 (MODY4) transcriptional activity. Molecular and Cellular Biology. 24: 4372-83. PMID 15121856 DOI: 10.1128/MCB.24.10.4372-4383.2004  1
2004 Heller RS, Stoffers DA, Liu A, Schedl A, Crenshaw EB, Madsen OD, Serup P. The role of Brn4/Pou3f4 and Pax6 in forming the pancreatic glucagon cell identity. Developmental Biology. 268: 123-34. PMID 15031110 DOI: 10.1016/j.ydbio.2003.12.008  1
2004 Esni F, Stoffers DA, Takeuchi T, Leach SD. Origin of exocrine pancreatic cells from nestin-positive precursors in developing mouse pancreas. Mechanisms of Development. 121: 15-25. PMID 14706696 DOI: 10.1016/j.mod.2003.08.010  1
2003 Brembeck FH, Schreiber FS, Deramaudt TB, Craig L, Rhoades B, Swain G, Grippo P, Stoffers DA, Silberg DG, Rustgi AK. The mutant K-ras oncogene causes pancreatic periductal lymphocytic infiltration and gastric mucous neck cell hyperplasia in transgenic mice. Cancer Research. 63: 2005-9. PMID 12727809  1
2003 Stoffers DA, Desai BM, DeLeon DD, Simmons RA. Neonatal exendin-4 prevents the development of diabetes in the intrauterine growth retarded rat. Diabetes. 52: 734-40. PMID 12606515 DOI: 10.2337/diabetes.52.3.734  1
2003 De León DD, Deng S, Madani R, Ahima RS, Drucker DJ, Stoffers DA. Role of endogenous glucagon-like peptide-1 in islet regeneration after partial pancreatectomy. Diabetes. 52: 365-71. PMID 12540609 DOI: 10.2337/diabetes.52.2.365  1
2002 Lee CS, Sund NJ, Vatamaniuk MZ, Matschinsky FM, Stoffers DA, Kaestner KH. Foxa2 controls Pdx1 gene expression in pancreatic beta-cells in vivo. Diabetes. 51: 2546-51. PMID 12145169  1
1999 Stoffers DA, Heller RS, Miller CP, Habener JF. Developmental Expression of the Homeodomain Protein IDX-1 in Mice Transgenic for an IDX-1 Promoter/lacZ Transcriptional Reporter1. Endocrinology. 140: 5374-5381. PMID 28204265 DOI: 10.1210/endo.140.11.7122  1
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