Lionel B. Ivashkiv - Publications

Affiliations: 
Weill Cornell Medical College, New York, NY, United States 
Area:
Cell Biology, Molecular Biology, Immunology

103 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Kang K, Bachu M, Park SH, Kang K, Bae S, Park-Min KH, Ivashkiv LB. IFN-γ selectively suppresses a subset of TLR4-activated genes and enhancers to potentiate macrophage activation. Nature Communications. 10: 3320. PMID 31346169 DOI: 10.1038/s41467-019-11147-3  0.92
2019 Kusnadi A, Park SH, Yuan R, Pannellini T, Giannopoulou E, Oliver D, Lu T, Park-Min KH, Ivashkiv LB. The Cytokine TNF Promotes Transcription Factor SREBP Activity and Binding to Inflammatory Genes to Activate Macrophages and Limit Tissue Repair. Immunity. PMID 31303399 DOI: 10.1016/j.immuni.2019.06.005  0.92
2019 Loh C, Park SH, Lee A, Yuan R, Ivashkiv LB, Kalliolias GD. TNF-induced inflammatory genes escape repression in fibroblast-like synoviocytes: transcriptomic and epigenomic analysis. Annals of the Rheumatic Diseases. PMID 31097419 DOI: 10.1136/annrheumdis-2018-214783  0.92
2019 Kuo D, Ding J, Cohn IS, Zhang F, Wei K, Rao DA, Rozo C, Sokhi UK, Shanaj S, Oliver DJ, Echeverria AP, DiCarlo EF, Brenner MB, Bykerk VP, Goodman SM, ... ... Ivashkiv LB, et al. HBEGF macrophages in rheumatoid arthritis induce fibroblast invasiveness. Science Translational Medicine. 11. PMID 31068444 DOI: 10.1126/scitranslmed.aau8587  0.44
2019 Donlin LT, Park SH, Giannopoulou E, Ivovic A, Park-Min KH, Siegel RM, Ivashkiv LB. Insights into rheumatic diseases from next-generation sequencing. Nature Reviews. Rheumatology. PMID 31000790 DOI: 10.1038/s41584-019-0217-7  0.92
2018 Donlin LT, Rao DA, Wei K, Slowikowski K, McGeachy MJ, Turner JD, Meednu N, Mizoguchi F, Gutierrez-Arcelus M, Lieb DJ, Keegan J, Muskat K, Hillman J, Rozo C, Ricker E, ... ... Ivashkiv LB, et al. Methods for high-dimensonal analysis of cells dissociated from cyropreserved synovial tissue. Arthritis Research & Therapy. 20: 139. PMID 29996944 DOI: 10.1186/s13075-018-1631-y  0.4
2018 Manni M, Gupta S, Ricker E, Chinenov Y, Park SH, Shi M, Pannellini T, Jessberger R, Ivashkiv LB, Pernis AB. Regulation of age-associated B cells by IRF5 in systemic autoimmunity. Nature Immunology. PMID 29483597 DOI: 10.1038/s41590-018-0056-8  0.92
2018 Mizoguchi F, Slowikowski K, Wei K, Marshall JL, Rao DA, Chang SK, Nguyen HN, Noss EH, Turner JD, Earp BE, Blazar PE, Wright J, Simmons BP, Donlin LT, Kalliolias GD, ... ... Ivashkiv LB, et al. Functionally distinct disease-associated fibroblast subsets in rheumatoid arthritis. Nature Communications. 9: 789. PMID 29476097 DOI: 10.1038/s41467-018-02892-y  0.32
2018 Stephenson W, Donlin LT, Butler A, Rozo C, Bracken B, Rashidfarrokhi A, Goodman SM, Ivashkiv LB, Bykerk VP, Orange DE, Darnell RB, Swerdlow HP, Satija R. Single-cell RNA-seq of rheumatoid arthritis synovial tissue using low-cost microfluidic instrumentation. Nature Communications. 9: 791. PMID 29476078 DOI: 10.1038/s41467-017-02659-x  0.4
2018 Orange DE, Agius P, DiCarlo EF, Robine N, Geiger H, Szymonifka J, McNamara M, Cummings R, Andersen KM, Mirza S, Figgie M, Ivashkiv L, Pernis AB, Jiang C, Frank M, et al. Machine learning integration of rheumatoid arthritis synovial histology and RNAseq data identifies three disease subtypes. Arthritis & Rheumatology (Hoboken, N.J.). PMID 29468833 DOI: 10.1002/art.40428  0.4
2018 Sokhi UK, Liber MP, Frye L, Park S, Kang K, Pannellini T, Zhao B, Norinsky R, Ivashkiv LB, Gong S. Dissection and function of autoimmunity-associated TNFAIP3 (A20) gene enhancers in humanized mouse models. Nature Communications. 9: 658. PMID 29440643 DOI: 10.1038/s41467-018-03081-7  0.64
2017 Park SH, Kang K, Giannopoulou E, Qiao Y, Kang K, Kim G, Park-Min KH, Ivashkiv LB. Type I interferons and the cytokine TNF cooperatively reprogram the macrophage epigenome to promote inflammatory activation. Nature Immunology. PMID 28825701 DOI: 10.1038/ni.3818  0.92
2017 Kang K, Park SH, Chen J, Qiao Y, Giannopoulou E, Berg K, Hanidu A, Li J, Nabozny G, Kang K, Park-Min KH, Ivashkiv LB. Interferon-γ Represses M2 Gene Expression in Human Macrophages by Disassembling Enhancers Bound by the Transcription Factor MAF. Immunity. 47: 235-250.e4. PMID 28813657 DOI: 10.1016/j.immuni.2017.07.017  0.92
2017 Murata K, Fang C, Terao C, Giannopoulou EG, Lee YJ, Lee MJ, Mun SH, Bae S, Qiao Y, Yuan R, Furu M, Ito H, Ohmura K, Matsuda S, Mimori T, ... ... Ivashkiv LB, et al. Hypoxia-Sensitive COMMD1 Integrates Signaling and Cellular Metabolism in Human Macrophages and Suppresses Osteoclastogenesis. Immunity. 47: 66-79.e5. PMID 28723554 DOI: 10.1016/j.immuni.2017.06.018  0.76
2017 Loupasakis K, Kuo D, Sokhi UK, Sohn C, Syracuse B, Giannopoulou EG, Park SH, Kang H, Rätsch G, Ivashkiv LB, Kalliolias GD. Tumor Necrosis Factor dynamically regulates the mRNA stabilome in rheumatoid arthritis fibroblast-like synoviocytes. Plos One. 12: e0179762. PMID 28708839 DOI: 10.1371/journal.pone.0179762  0.92
2017 Binder N, Miller C, Yoshida M, Inoue K, Nakano S, Hu X, Ivashkiv LB, Schett G, Pernis A, Goldring SR, Ross FP, Zhao B. Def6 Restrains Osteoclastogenesis and Inflammatory Bone Resorption. Journal of Immunology (Baltimore, Md. : 1950). PMID 28314855 DOI: 10.4049/jimmunol.1601716  0.56
2017 Rao DA, Gurish MF, Marshall JL, Slowikowski K, Fonseka CY, Liu Y, Donlin LT, Henderson LA, Wei K, Mizoguchi F, Teslovich NC, Weinblatt ME, Massarotti EM, Coblyn JS, Helfgott SM, ... ... Ivashkiv LB, et al. Pathologically expanded peripheral T helper cell subset drives B cells in rheumatoid arthritis. Nature. 542: 110-114. PMID 28150777 DOI: 10.1038/nature20810  0.4
2016 Qiao Y, Kang K, Giannopoulou E, Fang C, Ivashkiv LB. IFN-γ Induces Histone 3 Lysine 27 Trimethylation in a Small Subset of Promoters to Stably Silence Gene Expression in Human Macrophages. Cell Reports. 16: 3121-9. PMID 27653678 DOI: 10.1016/j.celrep.2016.08.051  0.64
2016 Huynh L, Kusnadi A, Park SH, Murata K, Park-Min KH, Ivashkiv LB. Opposing regulation of the late phase TNF response by mTORC1-IL-10 signaling and hypoxia in human macrophages. Scientific Reports. 6: 31959. PMID 27558590 DOI: 10.1038/srep31959  0.72
2016 Ivashkiv LB, Park SH. Epigenetic Regulation of Myeloid Cells. Microbiology Spectrum. 4. PMID 27337441 DOI: 10.1128/microbiolspec.MCHD-0010-2015  0.92
2016 Miller CH, Smith SM, Elguindy M, Zhang T, Xiang JZ, Hu X, Ivashkiv LB, Zhao B. RBP-J-Regulated miR-182 Promotes TNF-α-Induced Osteoclastogenesis. Journal of Immunology (Baltimore, Md. : 1950). PMID 27183593 DOI: 10.4049/jimmunol.1502044  0.72
2016 Fang C, Qiao Y, Mun SH, Lee MJ, Murata K, Bae S, Zhao B, Park-Min KH, Ivashkiv LB. Cutting Edge: EZH2 Promotes Osteoclastogenesis by Epigenetic Silencing of the Negative Regulator IRF8. Journal of Immunology (Baltimore, Md. : 1950). PMID 27183582 DOI: 10.4049/jimmunol.1501466  0.72
2016 Foldi J, Shang Y, Zhao B, Ivashkiv LB, Hu X. RBP-J is required for M2 macrophage polarization in response to chitin and mediates expression of a subset of M2 genes. Protein & Cell. PMID 26874522 DOI: 10.1007/s13238-016-0248-7  0.72
2016 Kalliolias GD, Ivashkiv LB. TNF biology, pathogenic mechanisms and emerging therapeutic strategies. Nature Reviews. Rheumatology. 12: 49-62. PMID 26656660 DOI: 10.1038/nrrheum.2015.169  0.32
2015 Lee MJ, Lim E, Mun S, Bae S, Murata K, Ivashkiv LB, Park-Min KH. Intravenous Immunoglobulin (IVIG) Attenuates TNF-Induced Pathologic Bone Resorption and Suppresses Osteoclastogenesis by Inducing A20 Expression. Journal of Cellular Physiology. PMID 26189496 DOI: 10.1002/jcp.25091  0.72
2015 Su X, Yu Y, Zhong Y, Giannopoulou EG, Hu X, Liu H, Cross JR, Rätsch G, Rice CM, Ivashkiv LB. Interferon-γ regulates cellular metabolism and mRNA translation to potentiate macrophage activation. Nature Immunology. 16: 838-49. PMID 26147685 DOI: 10.1038/ni.3205  0.72
2015 Chan CH, Fang C, Qiao Y, Yarilina A, Prinjha RK, Ivashkiv LB. BET bromodomain inhibition suppresses transcriptional responses to cytokine-Jak-STAT signaling in a gene-specific manner in human monocytes. European Journal of Immunology. 45: 287-97. PMID 25345375 DOI: 10.1002/eji.201444862  0.72
2015 Sohn C, Lee A, Qiao Y, Loupasakis K, Ivashkiv LB, Kalliolias GD. Prolonged tumor necrosis factor α primes fibroblast-like synoviocytes in a gene-specific manner by altering chromatin. Arthritis & Rheumatology (Hoboken, N.J.). 67: 86-95. PMID 25199798 DOI: 10.1002/art.38871  0.56
2014 Park-Min KH, Lim E, Lee MJ, Park SH, Giannopoulou E, Yarilina A, van der Meulen M, Zhao B, Smithers N, Witherington J, Lee K, Tak PP, Prinjha RK, Ivashkiv LB. Inhibition of osteoclastogenesis and inflammatory bone resorption by targeting BET proteins and epigenetic regulation. Nature Communications. 5: 5418. PMID 25391636 DOI: 10.1038/ncomms6418  0.92
2014 Li S, Miller CH, Giannopoulou E, Hu X, Ivashkiv LB, Zhao B. RBP-J imposes a requirement for ITAM-mediated costimulation of osteoclastogenesis. The Journal of Clinical Investigation. 124: 5057-73. PMID 25329696 DOI: 10.1172/JCI71882  0.72
2014 Donlin LT, Jayatilleke A, Giannopoulou EG, Kalliolias GD, Ivashkiv LB. Modulation of TNF-induced macrophage polarization by synovial fibroblasts. Journal of Immunology (Baltimore, Md. : 1950). 193: 2373-83. PMID 25057003 DOI: 10.4049/jimmunol.1400486  0.4
2014 Murray PJ, Allen JE, Biswas SK, Fisher EA, Gilroy DW, Goerdt S, Gordon S, Hamilton JA, Ivashkiv LB, Lawrence T, Locati M, Mantovani A, Martinez FO, Mege JL, Mosser DM, et al. Macrophage activation and polarization: nomenclature and experimental guidelines. Immunity. 41: 14-20. PMID 25035950 DOI: 10.1016/j.immuni.2014.06.008  0.72
2014 Ivashkiv LB, Donlin LT. Regulation of type I interferon responses. Nature Reviews. Immunology. 14: 36-49. PMID 24362405 DOI: 10.1038/nri3581  0.4
2013 Qiao Y, Giannopoulou EG, Chan CH, Park SH, Gong S, Chen J, Hu X, Elemento O, Ivashkiv LB. Synergistic activation of inflammatory cytokine genes by interferon-γ-induced chromatin remodeling and toll-like receptor signaling. Immunity. 39: 454-69. PMID 24012417 DOI: 10.1016/j.immuni.2013.08.009  0.92
2013 Chakravarty SD, Poulikakos PI, Ivashkiv LB, Salmon JE, Kalliolias GD. Kinase inhibitors: a new tool for the treatment of rheumatoid arthritis. Clinical Immunology (Orlando, Fla.). 148: 66-78. PMID 23651870 DOI: 10.1016/j.clim.2013.04.007  0.32
2013 Issuree PD, Maretzky T, McIlwain DR, Monette S, Qing X, Lang PA, Swendeman SL, Park-Min KH, Binder N, Kalliolias GD, Yarilina A, Horiuchi K, Ivashkiv LB, Mak TW, Salmon JE, et al. iRHOM2 is a critical pathogenic mediator of inflammatory arthritis. The Journal of Clinical Investigation. 123: 928-32. PMID 23348744 DOI: 10.1172/JCI66168  0.72
2013 Lee A, Qiao Y, Grigoriev G, Chen J, Park-Min KH, Park SH, Ivashkiv LB, Kalliolias GD. Tumor necrosis factor α induces sustained signaling and a prolonged and unremitting inflammatory response in rheumatoid arthritis synovial fibroblasts. Arthritis and Rheumatism. 65: 928-38. PMID 23335080 DOI: 10.1002/art.37853  0.92
2013 Park-Min KH, Lee EY, Moskowitz NK, Lim E, Lee SK, Lorenzo JA, Huang C, Melnick AM, Purdue PE, Goldring SR, Ivashkiv LB. Negative regulation of osteoclast precursor differentiation by CD11b and β2 integrin-B-cell lymphoma 6 signaling. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. 28: 135-49. PMID 22893614 DOI: 10.1002/jbmr.1739  0.72
2012 Yarilina A, Xu K, Chan C, Ivashkiv LB. Regulation of inflammatory responses in tumor necrosis factor-activated and rheumatoid arthritis synovial macrophages by JAK inhibitors. Arthritis and Rheumatism. 64: 3856-66. PMID 22941906 DOI: 10.1002/art.37691  0.48
2012 Gordon RA, Grigoriev G, Lee A, Kalliolias GD, Ivashkiv LB. The interferon signature and STAT1 expression in rheumatoid arthritis synovial fluid macrophages are induced by tumor necrosis factor α and counter-regulated by the synovial fluid microenvironment. Arthritis and Rheumatism. 64: 3119-28. PMID 22614743 DOI: 10.1002/art.34544  0.32
2012 Xu H, Zhu J, Smith S, Foldi J, Zhao B, Chung AY, Outtz H, Kitajewski J, Shi C, Weber S, Saftig P, Li Y, Ozato K, Blobel CP, Ivashkiv LB, et al. Notch-RBP-J signaling regulates the transcription factor IRF8 to promote inflammatory macrophage polarization. Nature Immunology. 13: 642-50. PMID 22610140 DOI: 10.1038/ni.2304  0.72
2012 Huynh L, Wang L, Shi C, Park-Min KH, Ivashkiv LB. ITAM-coupled receptors inhibit IFNAR signaling and alter macrophage responses to TLR4 and Listeria monocytogenes. Journal of Immunology (Baltimore, Md. : 1950). 188: 3447-57. PMID 22368279 DOI: 10.4049/jimmunol.1102211  0.76
2012 Zhao B, Grimes SN, Li S, Hu X, Ivashkiv LB. TNF-induced osteoclastogenesis and inflammatory bone resorption are inhibited by transcription factor RBP-J. The Journal of Experimental Medicine. 209: 319-34. PMID 22249448 DOI: 10.1084/jem.20111566  0.6
2011 Ivashkiv LB, Zhao B, Park-Min KH, Takami M. Feedback inhibition of osteoclastogenesis during inflammation by IL-10, M-CSF receptor shedding, and induction of IRF8. Annals of the New York Academy of Sciences. 1237: 88-94. PMID 22082370 DOI: 10.1111/j.1749-6632.2011.06217.x  0.76
2011 Zhao B, Ivashkiv LB. Negative regulation of osteoclastogenesis and bone resorption by cytokines and transcriptional repressors. Arthritis Research & Therapy. 13: 234. PMID 21861861 DOI: 10.1186/ar3379  0.6
2011 Park SH, Park-Min KH, Chen J, Hu X, Ivashkiv LB. Tumor necrosis factor induces GSK3 kinase-mediated cross-tolerance to endotoxin in macrophages. Nature Immunology. 12: 607-15. PMID 21602809 DOI: 10.1038/ni.2043  0.92
2011 Antoniv TT, Ivashkiv LB. Interleukin-10-induced gene expression and suppressive function are selectively modulated by the PI3K-Akt-GSK3 pathway. Immunology. 132: 567-77. PMID 21255011 DOI: 10.1111/j.1365-2567.2010.03402.x  0.6
2011 Yarilina A, Xu K, Chen J, Ivashkiv LB. TNF activates calcium-nuclear factor of activated T cells (NFAT)c1 signaling pathways in human macrophages. Proceedings of the National Academy of Sciences of the United States of America. 108: 1573-8. PMID 21220349 DOI: 10.1073/pnas.1010030108  0.48
2010 Chen J, Ivashkiv LB. IFN-γ abrogates endotoxin tolerance by facilitating Toll-like receptor-induced chromatin remodeling. Proceedings of the National Academy of Sciences of the United States of America. 107: 19438-43. PMID 20974955 DOI: 10.1073/pnas.1007816107  0.44
2010 Kalliolias GD, Gordon RA, Ivashkiv LB. Suppression of TNF-α and IL-1 signaling identifies a mechanism of homeostatic regulation of macrophages by IL-27. Journal of Immunology (Baltimore, Md. : 1950). 185: 7047-56. PMID 20971923 DOI: 10.4049/jimmunol.1001290  0.32
2010 Lee B, Kim TH, Jun JB, Yoo DH, Woo JH, Choi SJ, Lee YH, Song GG, Sohn J, Park-Min KH, Ivashkiv LB, Ji JD. Direct inhibition of human RANK+ osteoclast precursors identifies a homeostatic function of IL-1beta. Journal of Immunology (Baltimore, Md. : 1950). 185: 5926-34. PMID 20935210 DOI: 10.4049/jimmunol.1001591  0.72
2010 Ho HH, Ivashkiv LB. Downregulation of Friend leukemia virus integration 1 as a feedback mechanism that restrains lipopolysaccharide induction of matrix metalloproteases and interleukin-10 in human macrophages. Journal of Interferon & Cytokine Research : the Official Journal of the International Society For Interferon and Cytokine Research. 30: 893-900. PMID 20879862 DOI: 10.1089/jir.2010.0046  0.4
2010 Foldi J, Chung AY, Xu H, Zhu J, Outtz HH, Kitajewski J, Li Y, Hu X, Ivashkiv LB. Autoamplification of Notch signaling in macrophages by TLR-induced and RBP-J-dependent induction of Jagged1. Journal of Immunology (Baltimore, Md. : 1950). 185: 5023-31. PMID 20870935 DOI: 10.4049/jimmunol.1001544  0.72
2010 James DE, Nestor BJ, Sculco TP, Ivashkiv LB, Ross FP, Goldring SR, Purdue PE. The relative timing of exposure to phagocytosable particulates and to osteoclastogenic cytokines is critically important in the determination of myeloid cell fate. Journal of Immunology (Baltimore, Md. : 1950). 185: 1265-73. PMID 20543106 DOI: 10.4049/jimmunol.0902808  0.72
2010 Kalliolias GD, Ivashkiv LB. Overview of the biology of type I interferons. Arthritis Research & Therapy. 12: S1. PMID 20392288 DOI: 10.1186/ar2881  0.32
2010 Wang L, Gordon RA, Huynh L, Su X, Park Min KH, Han J, Arthur JS, Kalliolias GD, Ivashkiv LB. Indirect inhibition of Toll-like receptor and type I interferon responses by ITAM-coupled receptors and integrins. Immunity. 32: 518-30. PMID 20362473 DOI: 10.1016/j.immuni.2010.03.014  0.6
2010 Yarilina A, Ivashkiv LB. Type I interferon: a new player in TNF signaling. Current Directions in Autoimmunity. 11: 94-104. PMID 20173389 DOI: 10.1159/000289199  0.48
2010 Triantafyllopoulou A, Franzke CW, Seshan SV, Perino G, Kalliolias GD, Ramanujam M, van Rooijen N, Davidson A, Ivashkiv LB. Proliferative lesions and metalloproteinase activity in murine lupus nephritis mediated by type I interferons and macrophages. Proceedings of the National Academy of Sciences of the United States of America. 107: 3012-7. PMID 20133703 DOI: 10.1073/pnas.0914902107  0.32
2010 Kalliolias GD, Zhao B, Triantafyllopoulou A, Park-Min KH, Ivashkiv LB. Interleukin-27 inhibits human osteoclastogenesis by abrogating RANKL-mediated induction of nuclear factor of activated T cells c1 and suppressing proximal RANK signaling. Arthritis and Rheumatism. 62: 402-13. PMID 20112358 DOI: 10.1002/art.27200  0.76
2009 Kalliolias GD, Ivashkiv LB. Targeting cytokines in inflammatory diseases: focus on interleukin-1-mediated autoinflammation. F1000 Biology Reports. 1: 70. PMID 20948617 DOI: 10.3410/B1-70  0.32
2009 Ji JD, Park-Min KH, Shen Z, Fajardo RJ, Goldring SR, McHugh KP, Ivashkiv LB. Inhibition of RANK expression and osteoclastogenesis by TLRs and IFN-gamma in human osteoclast precursors. Journal of Immunology (Baltimore, Md. : 1950). 183: 7223-33. PMID 19890054 DOI: 10.4049/jimmunol.0900072  0.72
2009 Hu X, Ivashkiv LB. Cross-regulation of signaling pathways by interferon-gamma: implications for immune responses and autoimmune diseases. Immunity. 31: 539-50. PMID 19833085 DOI: 10.1016/j.immuni.2009.09.002  0.44
2009 Zhao B, Takami M, Yamada A, Wang X, Koga T, Hu X, Tamura T, Ozato K, Choi Y, Ivashkiv LB, Takayanagi H, Kamijo R. Interferon regulatory factor-8 regulates bone metabolism by suppressing osteoclastogenesis. Nature Medicine. 15: 1066-71. PMID 19718038 DOI: 10.1038/nm.2007  0.6
2009 Park-Min KH, Ji JD, Antoniv T, Reid AC, Silver RB, Humphrey MB, Nakamura M, Ivashkiv LB. IL-10 suppresses calcium-mediated costimulation of receptor activator NF-kappa B signaling during human osteoclast differentiation by inhibiting TREM-2 expression. Journal of Immunology (Baltimore, Md. : 1950). 183: 2444-55. PMID 19625651 DOI: 10.4049/jimmunol.0804165  0.72
2009 Ji JD, Park-Min KH, Ivashkiv LB. Expression and function of semaphorin 3A and its receptors in human monocyte-derived macrophages. Human Immunology. 70: 211-7. PMID 19480842 DOI: 10.1016/j.humimm.2009.01.026  0.76
2009 Ji JD, Ivashkiv LB. Roles of semaphorins in the immune and hematopoietic system. Rheumatology International. 29: 727-34. PMID 19139899 DOI: 10.1007/s00296-009-0852-4  0.76
2008 Hu X, Chakravarty SD, Ivashkiv LB. Regulation of interferon and Toll-like receptor signaling during macrophage activation by opposing feedforward and feedback inhibition mechanisms. Immunological Reviews. 226: 41-56. PMID 19161415 DOI: 10.1111/j.1600-065X.2008.00707.x  0.44
2008 Hu X, Chung AY, Wu I, Foldi J, Chen J, Ji JD, Tateya T, Kang YJ, Han J, Gessler M, Kageyama R, Ivashkiv LB. Integrated regulation of Toll-like receptor responses by Notch and interferon-gamma pathways. Immunity. 29: 691-703. PMID 18976936 DOI: 10.1016/j.immuni.2008.08.016  0.72
2008 Ho HH, Antoniv TT, Ji JD, Ivashkiv LB. Lipopolysaccharide-induced expression of matrix metalloproteinases in human monocytes is suppressed by IFN-gamma via superinduction of ATF-3 and suppression of AP-1. Journal of Immunology (Baltimore, Md. : 1950). 181: 5089-97. PMID 18802113  0.76
2008 Hu Y, Park-Min KH, Yarilina A, Ivashkiv LB. Regulation of STAT pathways and IRF1 during human dendritic cell maturation by TNF-alpha and PGE2. Journal of Leukocyte Biology. 84: 1353-60. PMID 18678606 DOI: 10.1189/jlb.0107040  0.76
2008 Hu Y, Hu X, Boumsell L, Ivashkiv LB. IFN-gamma and STAT1 arrest monocyte migration and modulate RAC/CDC42 pathways. Journal of Immunology (Baltimore, Md. : 1950). 180: 8057-65. PMID 18523269  0.48
2008 Kalliolias GD, Ivashkiv LB. IL-27 activates human monocytes via STAT1 and suppresses IL-10 production but the inflammatory functions of IL-27 are abrogated by TLRs and p38. Journal of Immunology (Baltimore, Md. : 1950). 180: 6325-33. PMID 18424756  0.32
2008 Yarilina A, Park-Min KH, Antoniv T, Hu X, Ivashkiv LB. TNF activates an IRF1-dependent autocrine loop leading to sustained expression of chemokines and STAT1-dependent type I interferon-response genes. Nature Immunology. 9: 378-87. PMID 18345002 DOI: 10.1038/ni1576  0.76
2008 Wang L, Tassiulas I, Park-Min KH, Reid AC, Gil-Henn H, Schlessinger J, Baron R, Zhang JJ, Ivashkiv LB. 'Tuning' of type I interferon-induced Jak-STAT1 signaling by calcium-dependent kinases in macrophages. Nature Immunology. 9: 186-93. PMID 18084294 DOI: 10.1038/ni1548  0.72
2007 Hu X, Chen J, Wang L, Ivashkiv LB. Crosstalk among Jak-STAT, Toll-like receptor, and ITAM-dependent pathways in macrophage activation. Journal of Leukocyte Biology. 82: 237-43. PMID 17502339 DOI: 10.1189/jlb.1206763  0.44
2007 Zhu W, Boachie-Adjei O, Rawlins BA, Frenkel B, Boskey AL, Ivashkiv LB, Blobel CP. A novel regulatory role for stromal-derived factor-1 signaling in bone morphogenic protein-2 osteogenic differentiation of mesenchymal C2C12 cells. The Journal of Biological Chemistry. 282: 18676-85. PMID 17439946 DOI: 10.1074/jbc.M610232200  0.72
2007 Tassiulas I, Park-Min KH, Hu Y, Kellerman L, Mevorach D, Ivashkiv LB. Apoptotic cells inhibit LPS-induced cytokine and chemokine production and IFN responses in macrophages. Human Immunology. 68: 156-64. PMID 17349870 DOI: 10.1016/j.humimm.2006.12.008  0.76
2007 Yarilina A, DiCarlo E, Ivashkiv LB. Suppression of the effector phase of inflammatory arthritis by double-stranded RNA is mediated by type I IFNs. Journal of Immunology (Baltimore, Md. : 1950). 178: 2204-11. PMID 17277125  0.48
2007 Park-Min KH, Serbina NV, Yang W, Ma X, Krystal G, Neel BG, Nutt SL, Hu X, Ivashkiv LB. FcγRIII-Dependent Inhibition of Interferon-γ Responses Mediates Suppressive Effects of Intravenous Immune Globulin Immunity. 26: 67-78. PMID 17239631 DOI: 10.1016/j.immuni.2006.11.010  0.72
2006 Antoniv TT, Ivashkiv LB. Dysregulation of interleukin-10-dependent gene expression in rheumatoid arthritis synovial macrophages. Arthritis and Rheumatism. 54: 2711-21. PMID 16947381 DOI: 10.1002/art.22055  0.6
2006 Rakshit DS, Lim JT, Ly K, Ivashkiv LB, Nestor BJ, Sculco TP, Purdue PE. Involvement of complement receptor 3 (CR3) and scavenger receptor in macrophage responses to wear debris. Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society. 24: 2036-44. PMID 16947312 DOI: 10.1002/jor.20275  0.72
2006 Sharif MN, Sosic D, Rothlin CV, Kelly E, Lemke G, Olson EN, Ivashkiv LB. Twist mediates suppression of inflammation by type I IFNs and Axl. The Journal of Experimental Medicine. 203: 1891-901. PMID 16831897 DOI: 10.1084/jem.20051725  0.72
2006 Hu X, Paik PK, Chen J, Yarilina A, Kockeritz L, Lu TT, Woodgett JR, Ivashkiv LB. IFN-gamma suppresses IL-10 production and synergizes with TLR2 by regulating GSK3 and CREB/AP-1 proteins. Immunity. 24: 563-74. PMID 16713974 DOI: 10.1016/j.immuni.2006.02.014  0.72
2006 Hu Y, Ivashkiv LB. Costimulation of chemokine receptor signaling by matrix metalloproteinase-9 mediates enhanced migration of IFN-alpha dendritic cells. Journal of Immunology (Baltimore, Md. : 1950). 176: 6022-33. PMID 16670311  0.48
2006 Rakshit DS, Ly K, Sengupta TK, Nestor BJ, Sculco TP, Ivashkiv LB, Purdue PE. Wear debris inhibition of anti-osteoclastogenic signaling by interleukin-6 and interferon-gamma. Mechanistic insights and implications for periprosthetic osteolysis. The Journal of Bone and Joint Surgery. American Volume. 88: 788-99. PMID 16595469 DOI: 10.2106/JBJS.E.00711  0.72
2006 Du Z, Kelly E, Mecklenbräuker I, Agle L, Herrero C, Paik P, Ivashkiv LB. Selective regulation of IL-10 signaling and function by zymosan. Journal of Immunology (Baltimore, Md. : 1950). 176: 4785-92. PMID 16585572  0.48
2006 Ho HH, Ivashkiv LB. Role of STAT3 in type I interferon responses. Negative regulation of STAT1-dependent inflammatory gene activation. The Journal of Biological Chemistry. 281: 14111-8. PMID 16571725 DOI: 10.1074/jbc.M511797200  0.4
2005 Antoniv TT, Park-Min KH, Ivashkiv LB. Kinetics of IL-10-induced gene expression in human macrophages. Immunobiology. 210: 87-95. PMID 16164015 DOI: 10.1016/j.imbio.2005.05.003  0.76
2005 Park-Min KH, Antoniv TT, Ivashkiv LB. Regulation of macrophage phenotype by long-term exposure to IL-10. Immunobiology. 210: 77-86. PMID 16164014 DOI: 10.1016/j.imbio.2005.05.002  0.76
2005 Hu X, Park-Min KH, Ho HH, Ivashkiv LB. IFN-gamma-primed macrophages exhibit increased CCR2-dependent migration and altered IFN-gamma responses mediated by Stat1. Journal of Immunology (Baltimore, Md. : 1950). 175: 3637-47. PMID 16148108  0.76
2005 Du Z, Shen Y, Yang W, Mecklenbrauker I, Neel BG, Ivashkiv LB. Inhibition of IFN-α signaling by a PKC- and protein tyrosine phosphatase SHP-2-dependent pathway Proceedings of the National Academy of Sciences of the United States of America. 102: 10267-10272. PMID 16000408 DOI: 10.1073/pnas.0408854102  0.72
2005 Hu X, Ho HH, Lou O, Hidaka C, Ivashkiv LB. Homeostatic role of interferons conferred by inhibition of IL-1-mediated inflammation and tissue destruction. Journal of Immunology (Baltimore, Md. : 1950). 175: 131-8. PMID 15972639  0.44
2004 Tassiulas I, Hu X, Ho H, Kashyap Y, Paik P, Hu Y, Lowell CA, Ivashkiv LB. Amplification of IFN-alpha-induced STAT1 activation and inflammatory function by Syk and ITAM-containing adaptors. Nature Immunology. 5: 1181-9. PMID 15467722 DOI: 10.1038/ni1126  0.48
2004 Ivashkiv LB, Hu X. Signaling by STATs. Arthritis Research & Therapy. 6: 159-68. PMID 15225360 DOI: 10.1186/ar1197  0.44
2004 Sharif MN, Tassiulas I, Hu Y, Mecklenbräuker I, Tarakhovsky A, Ivashkiv LB. IFN-alpha priming results in a gain of proinflammatory function by IL-10: implications for systemic lupus erythematosus pathogenesis. Journal of Immunology (Baltimore, Md. : 1950). 172: 6476-81. PMID 15128840  0.72
2003 Herrero C, Hu X, Li WP, Samuels S, Sharif MN, Kotenko S, Ivashkiv LB. Reprogramming of IL-10 activity and signaling by IFN-gamma. Journal of Immunology (Baltimore, Md. : 1950). 171: 5034-41. PMID 14607900  0.72
2003 Ivashkiv LB, Hu X. The JAK/STAT pathway in rheumatoid arthritis: pathogenic or protective? Arthritis and Rheumatism. 48: 2092-6. PMID 12905460 DOI: 10.1002/art.11095  0.44
2003 Ji JD, Tassiulas I, Park-Min KH, Aydin A, Mecklenbrauker I, Tarakhovsky A, Pricop L, Salmon JE, Ivashkiv LB. Inhibition of interleukin 10 signaling after Fc receptor ligation and during rheumatoid arthritis. The Journal of Experimental Medicine. 197: 1573-83. PMID 12782719 DOI: 10.1084/jem.20021820  0.76
2003 Hu X, Li WP, Meng C, Ivashkiv LB. Inhibition of IFN-gamma signaling by glucocorticoids. Journal of Immunology (Baltimore, Md. : 1950). 170: 4833-9. PMID 12707366  0.44
2003 Ivashkiv LB, Tassiulas I. Can SOCS make arthritis better? The Journal of Clinical Investigation. 111: 795-7. PMID 12639982 DOI: 10.1172/JCI18113  0.48
2002 Krause A, Scaletta N, Ji JD, Ivashkiv LB. Rheumatoid arthritis synoviocyte survival is dependent on Stat3. Journal of Immunology (Baltimore, Md. : 1950). 169: 6610-6. PMID 12444174  0.76
2002 Hu X, Herrero C, Li WP, Antoniv TT, Falck-Pedersen E, Koch AE, Woods JM, Haines GK, Ivashkiv LB. Sensitization of IFN-gamma Jak-STAT signaling during macrophage activation. Nature Immunology. 3: 859-66. PMID 12172544 DOI: 10.1038/ni828  0.72
2002 Ahmed ST, Mayer A, Ji JD, Ivashkiv LB. Inhibition of IL-6 signaling by a p38-dependent pathway occurs in the absence of new protein synthesis. Journal of Leukocyte Biology. 72: 154-62. PMID 12101275  0.72
Show low-probability matches.