Morley D. Hollenberg - Publications

Affiliations: 
University of Calgary, Calgary, Alberta, Canada 
Area:
Pharmacology, Molecular Biology, Animal Physiology Biology

108 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Pulakazhi Venu VK, Saifeddine M, Mihara K, Tsai YC, Nieves K, Alston L, Mani S, McCoy KD, Hollenberg MD, Hirota SA. The pregnane X receptor and its microbiota-derived ligand, indole 3-propionic acid, regulate endothelium-dependent vasodilation. American Journal of Physiology. Endocrinology and Metabolism. PMID 31211619 DOI: 10.1152/ajpendo.00572.2018  0.32
2019 Pulakazhi Venu VK, El-Daly M, Saifeddine M, Hirota SA, Ding H, Triggle CR, Hollenberg MD. Minimizing Hyperglycemia-Induced Vascular Endothelial Dysfunction by Inhibiting Endothelial Sodium-Glucose Cotransporter 2 and Attenuating Oxidative Stress: Implications for Treating Individuals With Type 2 Diabetes. Canadian Journal of Diabetes. PMID 30930073 DOI: 10.1016/j.jcjd.2019.01.005  0.32
2018 Yee MC, Nichols HL, Polley D, Saifeddine M, Pal K, Lee K, Wilson EH, Daines MO, Hollenberg MD, Boitano S, DeFea KA. Protease-activated Receptor-2 Signaling through β-Arrestin-2 Mediates Alternaria Alkaline Serine Protease-induced Airway Inflammation. American Journal of Physiology. Lung Cellular and Molecular Physiology. PMID 30335499 DOI: 10.1152/ajplung.00196.2018  0.32
2018 Eftekhari R, Lima SG, Liu Y, Mihara K, Saifeddine M, Noorbakhsh F, Scarisbrick IA, Hollenberg MD. Microenvironment proteinases, proteinase-activated receptor regulation, cancer and inflammation. Biological Chemistry. PMID 29924723 DOI: 10.1515/hsz-2018-0001  0.32
2018 El-Daly M, Venu VKP, Saifeddine M, Mihara K, Kang S, Fedak PWM, Alston LA, Hirota SA, Ding H, Triggle CR, Hollenberg MD. Hyperglycaemic impairment of PAR2-mediated vasodilation: Prevention by inhibition of aortic endothelial sodium-glucose-co-Transporter-2 and minimizing oxidative stress. Vascular Pharmacology. PMID 29908295 DOI: 10.1016/j.vph.2018.06.006  0.32
2018 Carr BJ, Mihara K, Ramachandran R, Saifeddine M, Nathanson NM, Stell WK, Hollenberg MD. Myopia-Inhibiting Concentrations of Muscarinic Receptor Antagonists Block Activation of Alpha2A-Adrenoceptors In Vitro. Investigative Ophthalmology & Visual Science. 59: 2778-2791. PMID 29860464 DOI: 10.1167/iovs.17-22562  0.32
2018 Venu VKP, Saifeddine M, Mihara K, El-Daly M, Belke D, Dean JLE, O'Brien ER, Hirota SA, Hollenberg MD. Heat-shock protein-27 and sex-selective regulation of muscarinic and PAR2 receptor-mediated Vasodilation: Differential sensitivity to eNOS inhibition. British Journal of Pharmacology. PMID 29532457 DOI: 10.1111/bph.14200  0.32
2017 Polley DJ, Mihara K, Ramachandran R, Vliagoftis H, Renaux B, Saifeddine M, Daines MO, Boitano S, Hollenberg MD. Cockroach allergen serine proteinases: Isolation, sequencing and signalling via proteinase-activated receptor-2 (PAR2). Clinical and Experimental Allergy : Journal of the British Society For Allergy and Clinical Immunology. PMID 28317204 DOI: 10.1111/cea.12921  0.32
2017 Ramachandran R, Mihara K, Thibeault P, Vanderboor CM, Petri B, Saifeddine M, Bouvier M, Hollenberg MD. Targeting a PAR4 carboxyl terminal motif to regulate platelet function. Molecular Pharmacology. PMID 28126849 DOI: 10.1124/mol.116.106526  0.32
2016 Mihara K, Ramachandran R, Saifeddine M, Hansen KK, Renaux B, Polley D, Gibson S, Vanderboor C, Hollenberg MD. Thrombin-Mediated Direct Activation of Proteinase-Activated Receptor-2: Another Target for Thrombin Signaling. Molecular Pharmacology. 89: 606-14. PMID 26957205 DOI: 10.1124/mol.115.102723  0.36
2015 Kamato D, Thach L, Getachew R, Burch M, Hollenberg MD, Zheng W, Little PJ, Osman N. Protease activated receptor-1 mediated dual kinase receptor transactivation stimulates the expression of glycosaminoglycan synthesizing genes. Cellular Signalling. PMID 26548632 DOI: 10.1016/j.cellsig.2015.11.003  0.36
2015 Kim W, Zekas E, Lodge R, Susan-Resiga D, Marcinkiewicz E, Essalmani R, Mihara K, Ramachandran R, Asahchop E, Gelman B, Cohen ÉA, Power C, Hollenberg MD, Seidah NG. Neuroinflammation-induced interactions between protease-activated receptor 1 and proprotein convertases in HIV-associated neurocognitive disorder. Molecular and Cellular Biology. PMID 26283733 DOI: 10.1128/MCB.00764-15  0.36
2015 Saifeddine M, El-Daly M, Mihara K, Bunnett NW, McIntyre P, Altier C, Hollenberg MD, Ramachandran R. GPCR-mediated EGF receptor transactivation regulates TRPV4 action in the vasculature. British Journal of Pharmacology. 172: 2493-506. PMID 25572823 DOI: 10.1111/bph.13072  0.36
2014 Iablokov V, Hirota CL, Peplowski MA, Ramachandran R, Mihara K, Hollenberg MD, MacNaughton WK. Proteinase-activated receptor 2 (PAR2) decreases apoptosis in colonic epithelial cells. The Journal of Biological Chemistry. 289: 34366-77. PMID 25331954 DOI: 10.1074/jbc.M114.610485  0.36
2014 Hollenberg MD. KLKs and their hormone-like signaling actions: a new life for the PSA-KLK family. Biological Chemistry. 395: 915-29. PMID 25153380 DOI: 10.1515/hsz-2014-0123  0.36
2014 Haerteis S, Krappitz A, Krappitz M, Murphy JE, Bertog M, Krueger B, Nacken R, Chung H, Hollenberg MD, Knecht W, Bunnett NW, Korbmacher C. Proteolytic activation of the human epithelial sodium channel by trypsin IV and trypsin I involves distinct cleavage sites. The Journal of Biological Chemistry. 289: 19067-78. PMID 24841206 DOI: 10.1074/jbc.M113.538470  0.36
2014 Fischer CD, Duquette SC, Renaux BS, Feener TD, Morck DW, Hollenberg MD, Lucas MJ, Buret AG. Tulathromycin exerts proresolving effects in bovine neutrophils by inhibiting phospholipases and altering leukotriene B4, prostaglandin E2, and lipoxin A4 production. Antimicrobial Agents and Chemotherapy. 58: 4298-307. PMID 24820086 DOI: 10.1128/AAC.02813-14  0.36
2014 Hollenberg MD. Hypothetical structure of prostate-specific antigen. Clinical Chemistry. 60: 702. PMID 24682692 DOI: 10.1373/clinchem.2014.221457  0.36
2014 El-Daly M, Saifeddine M, Mihara K, Ramachandran R, Triggle CR, Hollenberg MD. Proteinase-activated receptors 1 and 2 and the regulation of porcine coronary artery contractility: a role for distinct tyrosine kinase pathways. British Journal of Pharmacology. 171: 2413-25. PMID 24506284 DOI: 10.1111/bph.12593  0.36
2013 Stanton MM, Nelson LK, Benediktsson H, Hollenberg MD, Buret AG, Ceri H. Proteinase-activated receptor-1 and immunomodulatory effects of a PAR1-activating peptide in a mouse model of prostatitis. Mediators of Inflammation. 2013: 748395. PMID 24459330 DOI: 10.1155/2013/748395  0.36
2013 Chung H, Ramachandran R, Hollenberg MD, Muruve DA. Proteinase-activated receptor-2 transactivation of epidermal growth factor receptor and transforming growth factor-β receptor signaling pathways contributes to renal fibrosis. The Journal of Biological Chemistry. 288: 37319-31. PMID 24253040 DOI: 10.1074/jbc.M113.492793  0.36
2013 Sharma N, Fahr J, Renaux B, Saifeddine M, Kumar R, Nishikawa S, Mihara K, Ramachandran R, Hollenberg MD, Rancourt DE. Implantation serine proteinase 2 is a monomeric enzyme with mixed serine proteolytic activity and can silence signalling via proteinase activated receptors. Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire. 91: 487-97. PMID 24219291 DOI: 10.1139/bcb-2013-0006  0.36
2013 Gieseler F, Ungefroren H, Settmacher U, Hollenberg MD, Kaufmann R. Proteinase-activated receptors (PARs) - focus on receptor-receptor-interactions and their physiological and pathophysiological impact. Cell Communication and Signaling : Ccs. 11: 86. PMID 24215724 DOI: 10.1186/1478-811X-11-86  0.36
2013 Mihara K, Ramachandran R, Renaux B, Saifeddine M, Hollenberg MD. Neutrophil elastase and proteinase-3 trigger G protein-biased signaling through proteinase-activated receptor-1 (PAR1). The Journal of Biological Chemistry. 288: 32979-90. PMID 24052258 DOI: 10.1074/jbc.M113.483123  0.36
2013 Oikonomopoulou K, DeAngelis RA, Chen H, Diamandis EP, Hollenberg MD, Ricklin D, Lambris JD. Induction of complement C3a receptor responses by kallikrein-related peptidase 14. Journal of Immunology (Baltimore, Md. : 1950). 191: 3858-66. PMID 24014879 DOI: 10.4049/jimmunol.1202999  0.36
2013 Ramachandran R, Hyun E, Zhao L, Lapointe TK, Chapman K, Hirota CL, Ghosh S, McKemy DD, Vergnolle N, Beck PL, Altier C, Hollenberg MD. TRPM8 activation attenuates inflammatory responses in mouse models of colitis. Proceedings of the National Academy of Sciences of the United States of America. 110: 7476-81. PMID 23596210 DOI: 10.1073/pnas.1217431110  0.36
2013 Fernández-Blanco JA, Fernández-Blanco JA, Hollenberg MD, Martínez V, Vergara P. PAR-2-mediated control of barrier function and motility differs between early and late phases of postinfectious gut dysfunction in the rat. American Journal of Physiology. Gastrointestinal and Liver Physiology. 304: G390-400. PMID 23238933 DOI: 10.1152/ajpgi.00387.2012  0.36
2012 Hollenberg MD. CSCI/RCPSC Henry Friesen Lecture. Mentors and the butterfly effect: triggers for discovering signalling by proteinases via proteinase-activated receptors (PARs) and more. Clinical and Investigative Medicine. MéDecine Clinique Et Experimentale. 35: E378-91. PMID 23217564  0.36
2012 Nichols HL, Saffeddine M, Theriot BS, Hegde A, Polley D, El-Mays T, Vliagoftis H, Hollenberg MD, Wilson EH, Walker JK, DeFea KA. β-Arrestin-2 mediates the proinflammatory effects of proteinase-activated receptor-2 in the airway. Proceedings of the National Academy of Sciences of the United States of America. 109: 16660-5. PMID 23012429 DOI: 10.1073/pnas.1208881109  0.36
2012 Jijon HB, Buret A, Hirota CL, Hollenberg MD, Beck PL. The EGF receptor and HER2 participate in TNF-α-dependent MAPK activation and IL-8 secretion in intestinal epithelial cells. Mediators of Inflammation. 2012: 207398. PMID 22988345 DOI: 10.1155/2012/207398  0.36
2012 Hirota CL, Moreau F, Iablokov V, Dicay M, Renaux B, Hollenberg MD, MacNaughton WK. Epidermal growth factor receptor transactivation is required for proteinase-activated receptor-2-induced COX-2 expression in intestinal epithelial cells. American Journal of Physiology. Gastrointestinal and Liver Physiology. 303: G111-9. PMID 22517768 DOI: 10.1152/ajpgi.00358.2011  0.36
2012 Ramachandran R, Eissa A, Mihara K, Oikonomopoulou K, Saifeddine M, Renaux B, Diamandis E, Hollenberg MD. Proteinase-activated receptors (PARs): differential signalling by kallikrein-related peptidases KLK8 and KLK14. Biological Chemistry. 393: 421-7. PMID 22505524 DOI: 10.1515/hsz-2011-0251  0.36
2012 Chung H, Hamza M, Oikonomopoulou K, Gratio V, Saifeddine M, Virca GD, Diamandis EP, Hollenberg MD, Darmoul D. Kallikrein-related peptidase signaling in colon carcinoma cells: targeting proteinase-activated receptors. Biological Chemistry. 393: 413-20. PMID 22505523 DOI: 10.1515/bc-2011-231  0.36
2012 Kaufmann R, Hollenberg MD. Proteinase-activated receptors (PARs) and calcium signaling in cancer. Advances in Experimental Medicine and Biology. 740: 979-1000. PMID 22453980 DOI: 10.1007/978-94-007-2888-2_45  0.36
2012 Ramachandran R, Noorbakhsh F, Defea K, Hollenberg MD. Targeting proteinase-activated receptors: therapeutic potential and challenges. Nature Reviews. Drug Discovery. 11: 69-86. PMID 22212680 DOI: 10.1038/nrd3615  0.36
2012 Takei-Taniguchi R, Imai Y, Ishikawa C, Sakaguchi Y, Nakagawa N, Tsuda T, Hollenberg MD, Yamanishi K. Interleukin-17- and protease-activated receptor 2-mediated production of CXCL1 and CXCL8 modulated by cyclosporine A, vitamin D3 and glucocorticoids in human keratinocytes. The Journal of Dermatology. 39: 625-31. PMID 22211698 DOI: 10.1111/j.1346-8138.2011.01462.x  0.36
2012 Hollenberg MD. Novel insights into the delayed vasospasm following subarachnoid haemorrhage: importance of proteinase signalling. British Journal of Pharmacology. 165: 103-5. PMID 21718303 DOI: 10.1111/j.1476-5381.2011.01564.x  0.36
2011 Sharma N, Kumar R, Renaux B, Saifeddine M, Nishikawa S, Mihara K, Ramachandran R, Hollenberg MD, Rancourt DE. Implantation serine proteinase 1 exhibits mixed substrate specificity that silences signaling via proteinase-activated receptors. Plos One. 6: e27888. PMID 22132161 DOI: 10.1371/journal.pone.0027888  0.36
2011 Acharjee S, Zhu Y, Maingat F, Pardo C, Ballanyi K, Hollenberg MD, Power C. Proteinase-activated receptor-1 mediates dorsal root ganglion neuronal degeneration in HIV/AIDS. Brain : a Journal of Neurology. 134: 3209-21. PMID 22021895 DOI: 10.1093/brain/awr242  0.36
2011 Gratio V, Loriot C, Virca GD, Oikonomopoulou K, Walker F, Diamandis EP, Hollenberg MD, Darmoul D. Kallikrein-related peptidase 14 acts on proteinase-activated receptor 2 to induce signaling pathway in colon cancer cells. The American Journal of Pathology. 179: 2625-36. PMID 21907696 DOI: 10.1016/j.ajpath.2011.07.016  0.36
2011 Hyun E, Ramachandran R, Hollenberg MD, Vergnolle N. Mechanisms behind the anti-inflammatory actions of insulin. Critical Reviews in Immunology. 31: 307-40. PMID 21899513  0.36
2011 El Mays TY, Saifeddine M, Choudhury P, Hollenberg MD, Green FH. Carbon dioxide enhances substance P-induced epithelium-dependent bronchial smooth muscle relaxation in Sprague-Dawley rats. Canadian Journal of Physiology and Pharmacology. 89: 513-20. PMID 21812529 DOI: 10.1139/y11-052  0.36
2011 Carson L, Cathcart GR, Scott CJ, Hollenberg MD, Walker B, Ceri H, Gilmore BF. Comprehensive inhibitor profiling of the Proteus mirabilis metalloprotease virulence factor ZapA (mirabilysin). Biochimie. 93: 1824-7. PMID 21762758 DOI: 10.1016/j.biochi.2011.06.030  0.36
2011 Ramachandran R, Mihara K, Chung H, Renaux B, Lau CS, Muruve DA, DeFea KA, Bouvier M, Hollenberg MD. Neutrophil elastase acts as a biased agonist for proteinase-activated receptor-2 (PAR2). The Journal of Biological Chemistry. 286: 24638-48. PMID 21576245 DOI: 10.1074/jbc.M110.201988  0.36
2011 Shpacovitch VM, Feld M, Holzinger D, Kido M, Hollenberg MD, Levi-Schaffer F, Vergnolle N, Ludwig S, Roth J, Luger T, Steinhoff M. Role of proteinase-activated receptor-2 in anti-bacterial and immunomodulatory effects of interferon-γ on human neutrophils and monocytes. Immunology. 133: 329-39. PMID 21501162 DOI: 10.1111/j.1365-2567.2011.03443.x  0.36
2011 Adams MN, Ramachandran R, Yau MK, Suen JY, Fairlie DP, Hollenberg MD, Hooper JD. Structure, function and pathophysiology of protease activated receptors. Pharmacology & Therapeutics. 130: 248-82. PMID 21277892 DOI: 10.1016/j.pharmthera.2011.01.003  0.36
2011 Arizmendi NG, Abel M, Mihara K, Davidson C, Polley D, Nadeem A, El Mays T, Gilmore BF, Walker B, Gordon JR, Hollenberg MD, Vliagoftis H. Mucosal allergic sensitization to cockroach allergens is dependent on proteinase activity and proteinase-activated receptor-2 activation. Journal of Immunology (Baltimore, Md. : 1950). 186: 3164-72. PMID 21270400 DOI: 10.4049/jimmunol.0903812  0.36
2011 Goldblum SE, Rai U, Tripathi A, Thakar M, De Leo L, Di Toro N, Not T, Ramachandran R, Puche AC, Hollenberg MD, Fasano A. The active Zot domain (aa 288-293) increases ZO-1 and myosin 1C serine/threonine phosphorylation, alters interaction between ZO-1 and its binding partners, and induces tight junction disassembly through proteinase activated receptor 2 activation. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 25: 144-58. PMID 20852064 DOI: 10.1096/fj.10-158972  0.36
2010 Kim M, Hansen KK, Davis L, van Marle G, Gill MJ, Fox JD, Hollenberg MD, Rancourt DE, Lee PW, Yun CO, Johnston RN. Z-FA-FMK as a novel potent inhibitor of reovirus pathogenesis and oncolysis in vivo. Antiviral Therapy. 15: 897-905. PMID 20834102 DOI: 10.3851/IMP1646  0.36
2010 Wang J, Boerma M, Kulkarni A, Hollenberg MD, Hauer-Jensen M. Activation of protease activated receptor 2 by exogenous agonist exacerbates early radiation injury in rat intestine. International Journal of Radiation Oncology, Biology, Physics. 77: 1206-12. PMID 20610041 DOI: 10.1016/j.ijrobp.2009.12.075  0.36
2010 Csorba TR, Lyon AW, Hollenberg MD. Autoimmunity and the pathogenesis of type 1 diabetes. Critical Reviews in Clinical Laboratory Sciences. 47: 51-71. PMID 20545565 DOI: 10.3109/10408361003787171  0.36
2010 Blanco I, Béritze N, Argüelles M, Cárcaba V, Fernández F, Janciauskiene S, Oikonomopoulou K, de Serres FJ, Fernández-Bustillo E, Hollenberg MD. Abnormal overexpression of mastocytes in skin biopsies of fibromyalgia patients. Clinical Rheumatology. 29: 1403-12. PMID 20428906 DOI: 10.1007/s10067-010-1474-7  0.36
2010 Hollenberg MD. Getting the message across: pathophysiology and signaling via receptors for polypeptide hormones and proteinases. Clinical and Investigative Medicine. MéDecine Clinique Et Experimentale. 33: E133. PMID 20370993  0.36
2010 Oikonomopoulou K, Batruch I, Smith CR, Soosaipillai A, Diamandis EP, Hollenberg MD. Functional proteomics of kallikrein-related peptidases in ovarian cancer ascites fluid. Biological Chemistry. 391: 381-90. PMID 20180649 DOI: 10.1515/BC.2010.045  0.36
2010 Oikonomopoulou K, Diamandis EP, Hollenberg MD. Kallikrein-related peptidases: proteolysis and signaling in cancer, the new frontier. Biological Chemistry. 391: 299-310. PMID 20180639 DOI: 10.1515/BC.2010.038  0.36
2010 Al-Ani B, Hewett PW, Cudmore MJ, Fujisawa T, Saifeddine M, Williams H, Ramma W, Sissaoui S, Jayaraman PS, Ohba M, Ahmad S, Hollenberg MD, Ahmed A. Activation of proteinase-activated receptor 2 stimulates soluble vascular endothelial growth factor receptor 1 release via epidermal growth factor receptor transactivation in endothelial cells. Hypertension. 55: 689-97. PMID 20124108 DOI: 10.1161/HYPERTENSIONAHA.109.136333  0.36
2010 Hyun E, Ramachandran R, Cenac N, Houle S, Rousset P, Saxena A, Liblau RS, Hollenberg MD, Vergnolle N. Insulin modulates protease-activated receptor 2 signaling: implications for the innate immune response. Journal of Immunology (Baltimore, Md. : 1950). 184: 2702-9. PMID 20118282 DOI: 10.4049/jimmunol.0902171  0.36
2010 Noorbakhsh F, Ramachandran R, Barsby N, Ellestad KK, LeBlanc A, Dickie P, Baker G, Hollenberg MD, Cohen EA, Power C. MicroRNA profiling reveals new aspects of HIV neurodegeneration: caspase-6 regulates astrocyte survival. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 24: 1799-812. PMID 20097875 DOI: 10.1096/fj.09-147819  0.36
2010 Georgy SR, Pagel CN, Wong DM, Sivagurunathan S, Loh LH, Myers DE, Hollenberg MD, Pike RN, Mackie EJ. Proteinase-activated receptor-2 (PAR2) and mouse osteoblasts: regulation of cell function and lack of specificity of PAR2-activating peptides. Clinical and Experimental Pharmacology & Physiology. 37: 328-36. PMID 19769607 DOI: 10.1111/j.1440-1681.2009.05294.x  0.36
2010 Androutsou ME, Saifeddine M, Hollenberg MD, Matsoukas J, Agelis G. Design, synthesis and biological evaluation of non-peptide PAR1 thrombin receptor antagonists based on small bifunctional templates: arginine and phenylalanine side chain groups are keys for receptor activity. Amino Acids. 38: 985-90. PMID 19484400 DOI: 10.1007/s00726-009-0306-z  0.36
2009 Ramachandran R, Mihara K, Mathur M, Rochdi MD, Bouvier M, Defea K, Hollenberg MD. Agonist-biased signaling via proteinase activated receptor-2: differential activation of calcium and mitogen-activated protein kinase pathways. Molecular Pharmacology. 76: 791-801. PMID 19605524 DOI: 10.1124/mol.109.055509  0.36
2009 Kaufmann R, Oettel C, Horn A, Halbhuber KJ, Eitner A, Krieg R, Katenkamp K, Henklein P, Westermann M, Böhmer FD, Ramachandran R, Saifeddine M, Hollenberg MD, Settmacher U. Met receptor tyrosine kinase transactivation is involved in proteinase-activated receptor-2-mediated hepatocellular carcinoma cell invasion. Carcinogenesis. 30: 1487-96. PMID 19546160 DOI: 10.1093/carcin/bgp153  0.36
2009 Swystun VA, Renaux B, Moreau F, Wen S, Peplowski MA, Hollenberg MD, MacNaughton WK. Serine proteases decrease intestinal epithelial ion permeability by activation of protein kinase Czeta. American Journal of Physiology. Gastrointestinal and Liver Physiology. 297: G60-70. PMID 19460843 DOI: 10.1152/ajpgi.00096.2009  0.36
2009 Pittman QJ, Hollenberg MD. Urotensin I-CRF-Urocortins: a mermaid's tail. General and Comparative Endocrinology. 164: 7-14. PMID 19409389 DOI: 10.1016/j.ygcen.2009.04.024  0.36
2009 Zhu Y, Vergote D, Pardo C, Noorbakhsh F, McArthur JC, Hollenberg MD, Overall CM, Power C. CXCR3 activation by lentivirus infection suppresses neuronal autophagy: neuroprotective effects of antiretroviral therapy. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 23: 2928-41. PMID 19380511 DOI: 10.1096/fj.08-128819  0.36
2009 Xue M, Hollenberg MD, Demchuk A, Yong VW. Relative importance of proteinase-activated receptor-1 versus matrix metalloproteinases in intracerebral hemorrhage-mediated neurotoxicity in mice. Stroke; a Journal of Cerebral Circulation. 40: 2199-204. PMID 19359644 DOI: 10.1161/STROKEAHA.108.540393  0.36
2009 Wilson BJ, Harada R, LeDuy L, Hollenberg MD, Nepveu A. CUX1 transcription factor is a downstream effector of the proteinase-activated receptor 2 (PAR2). The Journal of Biological Chemistry. 284: 36-45. PMID 18952606 DOI: 10.1074/jbc.M803808200  0.36
2008 Ellis A, Cheng ZJ, Li Y, Jiang YF, Yang J, Pannirselvam M, Ding H, Hollenberg MD, Triggle CR. Effects of a Western diet versus high glucose on endothelium-dependent relaxation in murine micro- and macro-vasculature. European Journal of Pharmacology. 601: 111-7. PMID 18996368 DOI: 10.1016/j.ejphar.2008.10.042  0.36
2008 Sharma N, Oikonomopoulou K, Ito K, Renaux B, Diamandis EP, Hollenberg MD, Rancourt DE. Substrate specificity determination of mouse implantation serine proteinase and human kallikrein-related peptidase 6 by phage display. Biological Chemistry. 389: 1097-105. PMID 18979633 DOI: 10.1515/BC.2008.118  0.36
2008 Hansen KK, Oikonomopoulou K, Baruch A, Ramachandran R, Beck P, Diamandis EP, Hollenberg MD. Proteinases as hormones: targets and mechanisms for proteolytic signaling. Biological Chemistry. 389: 971-82. PMID 18979623 DOI: 10.1515/BC.2008.120  0.36
2008 Hollenberg MD, Oikonomopoulou K, Hansen KK, Saifeddine M, Ramachandran R, Diamandis EP. Kallikreins and proteinase-mediated signaling: proteinase-activated receptors (PARs) and the pathophysiology of inflammatory diseases and cancer. Biological Chemistry. 389: 643-51. PMID 18627296 DOI: 10.1515/BC.2008.077  0.36
2008 Oikonomopoulou K, Hansen KK, Baruch A, Hollenberg MD, Diamandis EP. Immunofluorometric activity-based probe analysis of active KLK6 in biological fluids. Biological Chemistry. 389: 747-56. PMID 18627291 DOI: 10.1515/BC.2008.086  0.36
2008 Rallabhandi P, Nhu QM, Toshchakov VY, Piao W, Medvedev AE, Hollenberg MD, Fasano A, Vogel SN. Analysis of proteinase-activated receptor 2 and TLR4 signal transduction: a novel paradigm for receptor cooperativity. The Journal of Biological Chemistry. 283: 24314-25. PMID 18622013 DOI: 10.1074/jbc.M804800200  0.36
2008 Hollenberg MD, Renaux B, Hyun E, Houle S, Vergnolle N, Saifeddine M, Ramachandran R. Derivatized 2-furoyl-LIGRLO-amide, a versatile and selective probe for proteinase-activated receptor 2: binding and visualization. The Journal of Pharmacology and Experimental Therapeutics. 326: 453-62. PMID 18477767 DOI: 10.1124/jpet.108.136432  0.36
2008 Feld M, Shpacovitch VM, Ehrhardt C, Kerkhoff C, Hollenberg MD, Vergnolle N, Ludwig S, Steinhoff M. Agonists of proteinase-activated receptor-2 enhance IFN-gamma-inducible effects on human monocytes: role in influenza A infection. Journal of Immunology (Baltimore, Md. : 1950). 180: 6903-10. PMID 18453611  0.36
2008 Yamada S, Ehlert FJ, Hollenberg MD. 5th International Symposium on receptor mechanisms, signal transduction and drug effects. Naunyn-Schmiedeberg's Archives of Pharmacology. 377: 267-8. PMID 18357439 DOI: 10.1007/s00210-008-0273-z  0.36
2008 van der Merwe JQ, Hollenberg MD, MacNaughton WK. EGF receptor transactivation and MAP kinase mediate proteinase-activated receptor-2-induced chloride secretion in intestinal epithelial cells. American Journal of Physiology. Gastrointestinal and Liver Physiology. 294: G441-51. PMID 18032480 DOI: 10.1152/ajpgi.00303.2007  0.36
2008 Wang H, Wen S, Bunnett NW, Leduc R, Hollenberg MD, MacNaughton WK. Proteinase-activated receptor-2 induces cyclooxygenase-2 expression through beta-catenin and cyclic AMP-response element-binding protein. The Journal of Biological Chemistry. 283: 809-15. PMID 17962194 DOI: 10.1074/jbc.M703021200  0.36
2008 Hansen KK, Oikonomopoulou K, Li Y, Hollenberg MD. Proteinases, proteinase-activated receptors (PARs) and the pathophysiology of cancer and diseases of the cardiovascular, musculoskeletal, nervous and gastrointestinal systems. Naunyn-Schmiedeberg's Archives of Pharmacology. 377: 377-92. PMID 17952408 DOI: 10.1007/s00210-007-0194-2  0.36
2007 Afkhami-Goli A, Noorbakhsh F, Keller AJ, Vergnolle N, Westaway D, Jhamandas JH, Andrade-Gordon P, Hollenberg MD, Arab H, Dyck RH, Power C. Proteinase-activated receptor-2 exerts protective and pathogenic cell type-specific effects in Alzheimer's disease. Journal of Immunology (Baltimore, Md. : 1950). 179: 5493-503. PMID 17911636  0.36
2007 Shpacovitch VM, Seeliger S, Huber-Lang M, Balkow S, Feld M, Hollenberg MD, Sarma VJ, Ward PA, Strey A, Gerke V, Sommerhoff CP, Vergnolle N, Steinhoff M. Agonists of proteinase-activated receptor-2 affect transendothelial migration and apoptosis of human neutrophils. Experimental Dermatology. 16: 799-806. PMID 17845211 DOI: 10.1111/j.1600-0625.2007.00605.x  0.36
2007 Saifeddine M, Seymour ML, Xiao YP, Compton SJ, Houle S, Ramachandran R, MacNaughton WK, Simonet S, Vayssettes-Courchay C, Verbeuren TJ, Hollenberg MD. Proteinase-activated receptor-2 activating peptides: distinct canine coronary artery receptor systems. American Journal of Physiology. Heart and Circulatory Physiology. 293: H3279-89. PMID 17766477 DOI: 10.1152/ajpheart.00519.2007  0.36
2007 Ebeling C, Lam T, Gordon JR, Hollenberg MD, Vliagoftis H. Proteinase-activated receptor-2 promotes allergic sensitization to an inhaled antigen through a TNF-mediated pathway. Journal of Immunology (Baltimore, Md. : 1950). 179: 2910-7. PMID 17709505  0.36
2007 Knecht W, Cottrell GS, Amadesi S, Mohlin J, SkÃ¥regärde A, Gedda K, Peterson A, Chapman K, Hollenberg MD, Vergnolle N, Bunnett NW. Trypsin IV or mesotrypsin and p23 cleave protease-activated receptors 1 and 2 to induce inflammation and hyperalgesia. The Journal of Biological Chemistry. 282: 26089-100. PMID 17623652 DOI: 10.1074/jbc.M703840200  0.36
2007 Kaufmann R, Rahn S, Pollrich K, Hertel J, Dittmar Y, Hommann M, Henklein P, Biskup C, Westermann M, Hollenberg MD, Settmacher U. Thrombin-mediated hepatocellular carcinoma cell migration: cooperative action via proteinase-activated receptors 1 and 4. Journal of Cellular Physiology. 211: 699-707. PMID 17323377 DOI: 10.1002/jcp.21027  0.36
2007 Ng ES, Cheng ZJ, Ellis A, Ding H, Jiang Y, Li Y, Hollenberg MD, Triggle CR. Nitrosothiol stores in vascular tissue: modulation by ultraviolet light, acetylcholine and ionomycin. European Journal of Pharmacology. 560: 183-92. PMID 17292350 DOI: 10.1016/j.ejphar.2007.01.016  0.36
2006 Vergote D, Butler GS, Ooms M, Cox JH, Silva C, Hollenberg MD, Jhamandas JH, Overall CM, Power C. Proteolytic processing of SDF-1alpha reveals a change in receptor specificity mediating HIV-associated neurodegeneration. Proceedings of the National Academy of Sciences of the United States of America. 103: 19182-7. PMID 17148615 DOI: 10.1073/pnas.0604678103  0.36
2006 Xue M, Hollenberg MD, Yong VW. Combination of thrombin and matrix metalloproteinase-9 exacerbates neurotoxicity in cell culture and intracerebral hemorrhage in mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 10281-91. PMID 17021183 DOI: 10.1523/JNEUROSCI.2806-06.2006  0.36
2006 Oikonomopoulou K, Hansen KK, Saifeddine M, Tea I, Blaber M, Blaber SI, Scarisbrick I, Andrade-Gordon P, Cottrell GS, Bunnett NW, Diamandis EP, Hollenberg MD. Proteinase-activated receptors, targets for kallikrein signaling. The Journal of Biological Chemistry. 281: 32095-112. PMID 16885167 DOI: 10.1074/jbc.M513138200  0.32
2006 Vergnolle N, Cellars L, Mencarelli A, Rizzo G, Swaminathan S, Beck P, Steinhoff M, Andrade-Gordon P, Bunnett NW, Hollenberg MD, Wallace JL, Cirino G, Fiorucci S. A role for proteinase-activated receptor-1 in inflammatory bowel diseases. The Journal of Clinical Investigation. 116: 2056. PMID 16881139 DOI: 10.1172/JCI21689R1  0.36
2006 Oikonomopoulou K, Hansen KK, Saifeddine M, Vergnolle N, Tea I, Blaber M, Blaber SI, Scarisbrick I, Diamandis EP, Hollenberg MD. Kallikrein-mediated cell signalling: targeting proteinase-activated receptors (PARs). Biological Chemistry. 387: 817-24. PMID 16800746 DOI: 10.1515/BC.2006.104  0.32
2006 Oikonomopoulou K, Hansen KK, Saifeddine M, Vergnolle N, Tea I, Diamandis EP, Hollenberg MD. Proteinase-mediated cell signalling: targeting proteinase-activated receptors (PARs) by kallikreins and more. Biological Chemistry. 387: 677-85. PMID 16800728 DOI: 10.1515/BC.2006.086  0.36
2006 Bergmann S, Junker K, Henklein P, Hollenberg MD, Settmacher U, Kaufmann R. PAR-type thrombin receptors in renal carcinoma cells: PAR1-mediated EGFR activation promotes cell migration. Oncology Reports. 15: 889-93. PMID 16525676  0.36
2006 Noorbakhsh F, Tsutsui S, Vergnolle N, Boven LA, Shariat N, Vodjgani M, Warren KG, Andrade-Gordon P, Hollenberg MD, Power C. Proteinase-activated receptor 2 modulates neuroinflammation in experimental autoimmune encephalomyelitis and multiple sclerosis. The Journal of Experimental Medicine. 203: 425-35. PMID 16476770 DOI: 10.1084/jem.20052148  0.36
2006 Koetzler R, Saifeddine M, Yu Z, Schürch FS, Hollenberg MD, Green FH. Surfactant as an airway smooth muscle relaxant. American Journal of Respiratory Cell and Molecular Biology. 34: 609-15. PMID 16415252 DOI: 10.1165/rcmb.2005-0228OC  0.36
2006 Adam E, Hansen KK, Astudillo Fernandez O, Astudillo OF, Coulon L, Bex F, Duhant X, Jaumotte E, Hollenberg MD, Jacquet A. The house dust mite allergen Der p 1, unlike Der p 3, stimulates the expression of interleukin-8 in human airway epithelial cells via a proteinase-activated receptor-2-independent mechanism. The Journal of Biological Chemistry. 281: 6910-23. PMID 16293628 DOI: 10.1074/jbc.M507140200  0.36
2006 Kelso EB, Lockhart JC, Hembrough T, Dunning L, Plevin R, Hollenberg MD, Sommerhoff CP, McLean JS, Ferrell WR. Therapeutic promise of proteinase-activated receptor-2 antagonism in joint inflammation Journal of Pharmacology and Experimental Therapeutics. 316: 1017-1024. PMID 16260582 DOI: 10.1124/jpet.105.093807  0.36
2006 Brown JK, Hollenberg MD, Jones CA. Tryptase activates phosphatidylinositol 3-kinases proteolytically independently from proteinase-activated receptor-2 in cultured dog airway smooth muscle cells. American Journal of Physiology. Lung Cellular and Molecular Physiology. 290: L259-69. PMID 16155087 DOI: 10.1152/ajplung.00215.2005  0.36
2005 Hollenberg MD, Houle S. Proteinases as hormone-like signal messengers: Proteinase-activated receptors and the pathophysiology of inflammation, pain, cardiovascular disease and cancer Swiss Medical Weekly. 135: 425-432. PMID 16208579  0.36
2005 Kawao N, Nagataki M, Nagasawa K, Kubo S, Cushing K, Wada T, Sekiguchi F, Ichida S, Hollenberg MD, MacNaughton WK, Nishikawa H, Kawabata A. Signal transduction for proteinase-activated receptor-2-triggered prostaglandin E2 formation in human lung epithelial cells Journal of Pharmacology and Experimental Therapeutics. 315: 576-589. PMID 16120814 DOI: 10.1124/jpet.105.089490  0.36
2005 Houle S, Papez MD, Ferazzini M, Hollenberg MD, Vergnolle N. Neutrophils and the kallikrein-kinin system in proteinase-activated receptor 4-mediated inflammation in rodents British Journal of Pharmacology. 146: 670-678. PMID 16100525 DOI: 10.1038/sj.bjp.0706371  0.36
2005 Seymour ML, Binion DG, Compton SJ, Hollenberg MD, MacNaughton WK. Expression of proteinase-activated receptor 2 on human primary gastrointestinal myofibroblasts and stimulation of prostaglandin synthesis Canadian Journal of Physiology and Pharmacology. 83: 605-616. PMID 16091786 DOI: 10.1139/y05-046  0.36
2005 Massi D, Naldini A, Ardinghi C, Carraro F, Franchi A, Paglierani M, Tarantini F, Ketabchi S, Cirino G, Hollenberg MD, Geppetti P, Santucci M. Expression of protease-activated receptors 1 and 2 in melanocytic nevi and malignant melanoma Human Pathology. 36: 676-685. PMID 16021575 DOI: 10.1016/j.humpath.2005.04.008  0.36
2003 Gui Y, Loutzenhiser R, Hollenberg MD. Bidirectional regulation of renal hemodynamics by activation of PAR1 and PAR2 in isolated perfused rat kidney. American Journal of Physiology. Renal Physiology. 285: F95-104. PMID 12644441 DOI: 10.1152/ajprenal.00396.2002  0.68
2000 Gui Y, Zheng XL, Hollenberg MD. Interleukin-1beta, Src- and non-Src tyrosine kinases, and nitric oxide synthase induction in rat aorta in vitro. American Journal of Physiology. Heart and Circulatory Physiology. 279: H566-76. PMID 10924055  0.68
1999 Hollenberg MD, Saifeddine M, Al-Ani B, Gui Y. Proteinase-activated receptor 4 (PAR4): action of PAR4-activating peptides in vascular and gastric tissue and lack of cross-reactivity with PAR1 and PAR2. Canadian Journal of Physiology and Pharmacology. 77: 458-64. PMID 10537233  0.68
1999 Zheng XL, Gui Y, Sharkey KA, Hollenberg MD. Differential induction of nitric oxide synthase in rat gastric and vascular smooth muscle tissue: distinct tissue distribution and distinctive signaling pathways. The Journal of Pharmacology and Experimental Therapeutics. 289: 632-40. PMID 10215633  0.36
1997 Zheng XL, Sharkey KA, Hollenberg MD. Induction of nitric oxide synthase in rat gastric smooth muscle preparations. American Journal of Physiology. Gastrointestinal and Liver Physiology. 273: G1101-G1107. PMID 29585430 DOI: 10.1152/ajpgi.1997.273.5.G1101  0.68
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