| Year |
Citation |
Score |
| 2024 |
Guignard S, Saifeddine M, Mihara K, Motahhary M, Savignac M, Guiraud L, Sagnat D, Sebbag M, Khou S, Rolland C, Edir A, Bournet B, Buscail L, Buscail E, Alric L, ... ... Hollenberg MD, et al. Chymotrypsin activity signals to intestinal epithelium by protease-activated receptor-dependent mechanisms. British Journal of Pharmacology. PMID 38637276 DOI: 10.1111/bph.16341 |
0.307 |
|
| 2023 |
Yan B, Gui Y, Guo Y, Sun J, Saifeddine M, Deng J, Hill JA, Hollenberg MD, Jiang ZS, Zheng XL. Impact of Short-Term (+)-JQ1 Exposure on Mouse Aorta: Unanticipated Inhibition of Smooth Muscle Contractility. Cells. 12. PMID 37296583 DOI: 10.3390/cells12111461 |
0.62 |
|
| 2022 |
Kaiserman D, Zhao P, Rowe CL, Leong A, Barlow N, Joeckel LT, Hitchen C, Stewart SE, Hollenberg MD, Bunnett N, Suhrbier A, Bird PI. Granzyme K initiates IL-6 and IL-8 release from epithelial cells by activating protease-activated receptor 2. Plos One. 17: e0270584. PMID 35881628 DOI: 10.1371/journal.pone.0270584 |
0.3 |
|
| 2022 |
Fekete E, Allain T, Amat CB, Mihara K, Saifeddine M, Hollenberg MD, Chadee K, Buret AG. Giardia duodenalis cysteine proteases cleave proteinase-activated receptor-2 to regulate intestinal goblet cell mucin gene expression. International Journal For Parasitology. PMID 35077730 DOI: 10.1016/j.ijpara.2021.11.011 |
0.365 |
|
| 2020 |
Holani R, Babbar A, Blyth GAD, Lopes F, Jijon H, McKay DM, Hollenberg MD, Cobo ER. Cathelicidin-mediated lipopolysaccharide signaling via intracellular TLR4 in colonic epithelial cells evokes CXCL8 production. Gut Microbes. 1-24. PMID 32658599 DOI: 10.1080/19490976.2020.1785802 |
0.365 |
|
| 2020 |
Triggle CR, Ding H, Marei I, Anderson TJ, Hollenberg MD. Why the endothelium? The endothelium as a target to reduce diabetes-associated vascular disease.' Canadian Journal of Physiology and Pharmacology. PMID 32150686 DOI: 10.1139/Cjpp-2019-0677 |
0.313 |
|
| 2020 |
Fekete ER, Amat C, Allain T, Mihara K, Hollenberg M, Chadee K, Buret A. Alterations to Mucus Production and Secretion during
Giardia
Infection Involve
Giardia
Protease Activity and PAR2 Activation The Faseb Journal. 34: 1-1. DOI: 10.1096/Fasebj.2020.34.S1.02365 |
0.317 |
|
| 2020 |
Venu VKP, Saifeddine M, Mihara K, Kamal B, Lantela D, Hollenberg MD. NON‐PSYCHOACTIVE CANNABINOIDS (CBD/CBG) ACT VIA CANNABINOID CB2/CB1 RECEPTORS TO REGULATE INTESTINAL MYOFIBROBLAST METABOLIC ACTIVITY AND TO INHIBIT FORSKOLIN‐MEDIATED ELEVATION OF CYCLIC‐AMP The Faseb Journal. 34: 1-1. DOI: 10.1096/Fasebj.2020.34.S1.02225 |
0.394 |
|
| 2019 |
Otterbein H, Mihara K, Hollenberg MD, Lehnert H, Witte D, Ungefroren H. RAC1B Suppresses TGF-β-Dependent Chemokinesis and Growth Inhibition through an Autoregulatory Feed-Forward Loop Involving PAR2 and ALK5. Cancers. 11. PMID 31434318 DOI: 10.3390/Cancers11081211 |
0.327 |
|
| 2019 |
Motta JP, Denadai-Souza A, Sagnat D, Guiraud L, Edir A, Bonnart C, Sebbag M, Rousset P, Lapeyre A, Seguy C, Mathurine-Thomas N, Galipeau HJ, Bonnet D, Alric L, Buret AG, ... ... Hollenberg MD, et al. Active thrombin produced by the intestinal epithelium controls mucosal biofilms. Nature Communications. 10: 3224. PMID 31324782 DOI: 10.1038/S41467-019-11140-W |
0.309 |
|
| 2019 |
Pulakazhi Venu VK, Saifeddine M, Mihara K, Tsai YC, Nieves K, Alston L, Mani S, McCoy KD, Hollenberg MD, Hirota SA. The pregnane X receptor and its microbiota-derived ligand, indole 3-propionic acid, regulate endothelium-dependent vasodilation. American Journal of Physiology. Endocrinology and Metabolism. PMID 31211619 DOI: 10.1152/Ajpendo.00572.2018 |
0.36 |
|
| 2019 |
Ungefroren H, Otterbein H, Fiedler C, Mihara K, Hollenberg MD, Gieseler F, Lehnert H, Witte D. RAC1B Suppresses TGF-β1-Dependent Cell Migration in Pancreatic Carcinoma Cells through Inhibition of the TGF-β Type I Receptor ALK5. Cancers. 11. PMID 31108998 DOI: 10.3390/Cancers11050691 |
0.334 |
|
| 2019 |
Rayees S, Joshi JC, Tauseef M, Anwar M, Baweja S, Rochford I, Joshi B, Hollenberg MD, Reddy SP, Mehta D. PAR2-Mediated cAMP Generation Suppresses TRPV4-Dependent Ca Signaling in Alveolar Macrophages to Resolve TLR4-Induced Inflammation. Cell Reports. 27: 793-805.e4. PMID 30995477 DOI: 10.1016/J.Celrep.2019.03.053 |
0.36 |
|
| 2019 |
Sachan V, Lodge R, Mihara K, Hamelin J, Power C, Gelman BB, Hollenberg MD, Cohen ÉA, Seidah NG. HIV-induced neuroinflammation: impact of PAR1 and PAR2 processing by Furin. Cell Death and Differentiation. PMID 30683917 DOI: 10.1038/S41418-018-0264-7 |
0.339 |
|
| 2019 |
Bunnett N, DeFea K, Hamilton J, Hollenberg MD, Ramachandran R, Trejo J. Proteinase-activated receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database Iuphar/Bps Guide to Pharmacology Cite. 2019. DOI: 10.2218/gtopdb/f59/2019.4 |
0.382 |
|
| 2018 |
Yee MC, Nichols HL, Polley D, Saifeddine M, Pal K, Lee K, Wilson EH, Daines MO, Hollenberg MD, Boitano S, DeFea KA. Protease-activated Receptor-2 Signaling through β-Arrestin-2 Mediates Alternaria Alkaline Serine Protease-induced Airway Inflammation. American Journal of Physiology. Lung Cellular and Molecular Physiology. PMID 30335499 DOI: 10.1152/Ajplung.00196.2018 |
0.334 |
|
| 2018 |
Peplowski MA, Dicay M, Baggio CH, Wysokinski F, Renaux B, Hollenberg MD, Proud D, MacNaughton WK. Interferon gamma decreases intestinal epithelial aquaporin 3 expression through downregulation of constitutive transcription. Journal of Molecular Medicine (Berlin, Germany). PMID 30090948 DOI: 10.1007/S00109-018-1681-2 |
0.303 |
|
| 2018 |
Eftekhari R, Lima SG, Liu Y, Mihara K, Saifeddine M, Noorbakhsh F, Scarisbrick IA, Hollenberg MD. Microenvironment proteinases, proteinase-activated receptor regulation, cancer and inflammation. Biological Chemistry. PMID 29924723 DOI: 10.1515/Hsz-2018-0001 |
0.341 |
|
| 2018 |
El-Daly M, Venu VKP, Saifeddine M, Mihara K, Kang S, Fedak PWM, Alston LA, Hirota SA, Ding H, Triggle CR, Hollenberg MD. Hyperglycaemic impairment of PAR2-mediated vasodilation: Prevention by inhibition of aortic endothelial sodium-glucose-co-Transporter-2 and minimizing oxidative stress. Vascular Pharmacology. PMID 29908295 DOI: 10.1016/J.Vph.2018.06.006 |
0.38 |
|
| 2018 |
Carr BJ, Mihara K, Ramachandran R, Saifeddine M, Nathanson NM, Stell WK, Hollenberg MD. Myopia-Inhibiting Concentrations of Muscarinic Receptor Antagonists Block Activation of Alpha2A-Adrenoceptors In Vitro. Investigative Ophthalmology & Visual Science. 59: 2778-2791. PMID 29860464 DOI: 10.1167/Iovs.17-22562 |
0.373 |
|
| 2018 |
Denadai-Souza A, Bonnart C, Tapias NS, Marcellin M, Gilmore B, Alric L, Bonnet D, Burlet-Schiltz O, Hollenberg MD, Vergnolle N, Deraison C. Functional Proteomic Profiling of Secreted Serine Proteases in Health and Inflammatory Bowel Disease. Scientific Reports. 8: 7834. PMID 29777136 DOI: 10.1038/S41598-018-26282-Y |
0.34 |
|
| 2018 |
Moges R, De Lamache DD, Sajedy S, Renaux BS, Hollenberg MD, Muench G, Abbott EM, Buret AG. Anti-Inflammatory Benefits of Antibiotics: Tylvalosin Induces Apoptosis of Porcine Neutrophils and Macrophages, Promotes Efferocytosis, and Inhibits Pro-Inflammatory CXCL-8, IL1α, and LTB Production, While Inducing the Release of Pro-Resolving Lipoxin A and Resolvin D1. Frontiers in Veterinary Science. 5: 57. PMID 29696149 DOI: 10.3389/Fvets.2018.00057 |
0.322 |
|
| 2018 |
Venu VKP, Saifeddine M, Mihara K, El-Daly M, Belke D, Dean JLE, O'Brien ER, Hirota SA, Hollenberg MD. Heat-shock protein-27 and sex-selective regulation of muscarinic and PAR2 receptor-mediated Vasodilation: Differential sensitivity to eNOS inhibition. British Journal of Pharmacology. PMID 29532457 DOI: 10.1111/Bph.14200 |
0.4 |
|
| 2018 |
Oikonomopoulou K, Diamandis EP, Hollenberg MD, Chandran V. Proteinases and their receptors in inflammatory arthritis: an overview. Nature Reviews. Rheumatology. PMID 29416136 DOI: 10.1038/Nrrheum.2018.17 |
0.397 |
|
| 2018 |
van den Boogaard FE, Brands X, Duitman J, de Stoppelaar SF, Borensztajn KS, Roelofs JJTH, Hollenberg MD, Spek CA, Schultz MJ, van 't Veer C, van der Poll T. Protease-Activated Receptor 2 Facilitates Bacterial Dissemination in Pneumococcal Pneumonia. The Journal of Infectious Diseases. PMID 29415278 DOI: 10.1093/Infdis/Jiy010 |
0.351 |
|
| 2017 |
Peplowski MA, Vegso AJ, Iablokov V, Dicay M, Zaheer RS, Renaux B, Proud D, Hollenberg MD, Beck PL, MacNaughton WK. Tumor necrosis factor α decreases aquaporin 3 expression in intestinal epithelial cells through inhibition of constitutive transcription. Physiological Reports. 5. PMID 29038361 DOI: 10.14814/Phy2.13451 |
0.321 |
|
| 2017 |
Ungefroren H, Witte D, Mihara K, Rauch BH, Henklein P, Johren O, Bonni S, Settmacher U, Lehnert H, Hollenberg MD, Kaufmann R, Gieseler F. TGF-β1/ALK5-mediated cell migration is dependent on the protein PAR2 but not on PAR2-stimulated Gq-calcium signaling. Molecular Pharmacology. PMID 28842394 DOI: 10.1124/Mol.117.109017 |
0.321 |
|
| 2017 |
Polley DJ, Mihara K, Ramachandran R, Vliagoftis H, Renaux B, Saifeddine M, Daines MO, Boitano S, Hollenberg MD. Cockroach allergen serine proteinases: Isolation, sequencing and signalling via proteinase-activated receptor-2 (PAR2). Clinical and Experimental Allergy : Journal of the British Society For Allergy and Clinical Immunology. PMID 28317204 DOI: 10.1111/Cea.12921 |
0.391 |
|
| 2017 |
Chaplin R, Thach L, Hollenberg MD, Cao Y, Little PJ, Kamato D. Insights into cellular signalling by G protein coupled receptor transactivation of cell surface protein kinase receptors. Journal of Cell Communication and Signaling. PMID 28168348 DOI: 10.1007/S12079-017-0375-9 |
0.404 |
|
| 2017 |
Ramachandran R, Mihara K, Thibeault P, Vanderboor CM, Petri B, Saifeddine M, Bouvier M, Hollenberg MD. Targeting a PAR4 carboxyl terminal motif to regulate platelet function. Molecular Pharmacology. PMID 28126849 DOI: 10.1124/Mol.116.106526 |
0.366 |
|
| 2017 |
Gibson SG, Mihara K, Zijlstra A, Hyndman ME, Hollenberg MD. Abstract 2014: Genitourinary cancer-derived cells produce microenvironment proteinases that regulate proteinase activated receptors (PARs) to drive oncogenic signaling Cancer Research. 77: 2014-2014. DOI: 10.1158/1538-7445.Am2017-2014 |
0.4 |
|
| 2016 |
Ramachandran R, Altier C, Oikonomopoulou K, Hollenberg MD. Proteinases, Their Extracellular Targets, and Inflammatory Signaling. Pharmacological Reviews. 68: 1110-1142. PMID 27677721 DOI: 10.1124/pr.115.010991 |
0.314 |
|
| 2016 |
Gillrie MR, Renaux B, Russell-Goldman E, Avril M, Brazier AJ, Mihara K, Di Cera E, Milner DA, Hollenberg MD, Smith JD, Ho M. Thrombin Cleavage of Plasmodium falciparum Erythrocyte Membrane Protein 1 Inhibits Cytoadherence. Mbio. 7. PMID 27624125 DOI: 10.1128/Mbio.01120-16 |
0.325 |
|
| 2016 |
Zeeh F, Witte D, Gädeken T, Rauch BH, Grage-Griebenow E, Leinung N, Fromm SJ, Stölting S, Mihara K, Kaufmann R, Settmacher U, Lehnert H, Hollenberg MD, Ungefroren H. Proteinase-activated receptor 2 promotes TGF-β-dependent cell motility in pancreatic cancer cells by sustaining expression of the TGF-β type I receptor ALK5. Oncotarget. PMID 27248167 DOI: 10.18632/Oncotarget.9600 |
0.363 |
|
| 2016 |
Mihara K, Ramachandran R, Saifeddine M, Hansen KK, Renaux B, Polley D, Gibson S, Vanderboor C, Hollenberg MD. Thrombin-Mediated Direct Activation of Proteinase-Activated Receptor-2: Another Target for Thrombin Signaling. Molecular Pharmacology. 89: 606-14. PMID 26957205 DOI: 10.1124/Mol.115.102723 |
0.428 |
|
| 2015 |
Kamato D, Thach L, Getachew R, Burch M, Hollenberg MD, Zheng W, Little PJ, Osman N. Protease activated receptor-1 mediated dual kinase receptor transactivation stimulates the expression of glycosaminoglycan synthesizing genes. Cellular Signalling. PMID 26548632 DOI: 10.1016/J.Cellsig.2015.11.003 |
0.42 |
|
| 2015 |
Asaduzzaman M, Nadeem A, Arizmendi N, Davidson C, Nichols HL, Abel M, Ionescu LI, Puttagunta L, Thebaud B, Gordon J, DeFea K, Hollenberg MD, Vliagoftis H. Functional inhibition of PAR2 alleviates allergen-induced airway hyperresponsiveness and inflammation. Clinical and Experimental Allergy : Journal of the British Society For Allergy and Clinical Immunology. PMID 26312432 DOI: 10.1111/Cea.12628 |
0.404 |
|
| 2015 |
Kim W, Zekas E, Lodge R, Susan-Resiga D, Marcinkiewicz E, Essalmani R, Mihara K, Ramachandran R, Asahchop E, Gelman B, Cohen ÉA, Power C, Hollenberg MD, Seidah NG. Neuroinflammation-induced interactions between protease-activated receptor 1 and proprotein convertases in HIV-associated neurocognitive disorder. Molecular and Cellular Biology. PMID 26283733 DOI: 10.1128/Mcb.00764-15 |
0.319 |
|
| 2015 |
Saifeddine M, El-Daly M, Mihara K, Bunnett NW, McIntyre P, Altier C, Hollenberg MD, Ramachandran R. GPCR-mediated EGF receptor transactivation regulates TRPV4 action in the vasculature. British Journal of Pharmacology. 172: 2493-506. PMID 25572823 DOI: 10.1111/Bph.13072 |
0.394 |
|
| 2015 |
Hollenberg MD. Proteinases, their receptors and inflammatory signalling: the Oxford South Parks Road connection. British Journal of Pharmacology. 172: 3196-211. PMID 25521749 DOI: 10.1111/Bph.13041 |
0.36 |
|
| 2015 |
Darby W, Potocnik S, Hollenberg M, Woodman O, McIntyre P. Shear Stress Potentiates TRPV4 Effects on Acetylcholine-Dependent Vasodilatation The Faseb Journal. 29. DOI: 10.1096/Fasebj.29.1_Supplement.627.9 |
0.35 |
|
| 2014 |
Iablokov V, Hirota CL, Peplowski MA, Ramachandran R, Mihara K, Hollenberg MD, MacNaughton WK. Proteinase-activated receptor 2 (PAR2) decreases apoptosis in colonic epithelial cells. The Journal of Biological Chemistry. 289: 34366-77. PMID 25331954 DOI: 10.1074/Jbc.M114.610485 |
0.398 |
|
| 2014 |
Joyal JS, Nim S, Zhu T, Sitaras N, Rivera JC, Shao Z, Sapieha P, Hamel D, Sanchez M, Zaniolo K, St-Louis M, Ouellette J, Montoya-Zavala M, Zabeida A, Picard E, ... ... Hollenberg M, et al. Subcellular localization of coagulation factor II receptor-like 1 in neurons governs angiogenesis. Nature Medicine. 20: 1165-73. PMID 25216639 DOI: 10.1038/Nm.3669 |
0.363 |
|
| 2014 |
Hollenberg MD. KLKs and their hormone-like signaling actions: a new life for the PSA-KLK family. Biological Chemistry. 395: 915-29. PMID 25153380 DOI: 10.1515/Hsz-2014-0123 |
0.339 |
|
| 2014 |
Haerteis S, Krappitz A, Krappitz M, Murphy JE, Bertog M, Krueger B, Nacken R, Chung H, Hollenberg MD, Knecht W, Bunnett NW, Korbmacher C. Proteolytic activation of the human epithelial sodium channel by trypsin IV and trypsin I involves distinct cleavage sites. The Journal of Biological Chemistry. 289: 19067-78. PMID 24841206 DOI: 10.1074/Jbc.M113.538470 |
0.361 |
|
| 2014 |
Fischer CD, Duquette SC, Renaux BS, Feener TD, Morck DW, Hollenberg MD, Lucas MJ, Buret AG. Tulathromycin exerts proresolving effects in bovine neutrophils by inhibiting phospholipases and altering leukotriene B4, prostaglandin E2, and lipoxin A4 production. Antimicrobial Agents and Chemotherapy. 58: 4298-307. PMID 24820086 DOI: 10.1128/Aac.02813-14 |
0.301 |
|
| 2014 |
El-Daly M, Saifeddine M, Mihara K, Ramachandran R, Triggle CR, Hollenberg MD. Proteinase-activated receptors 1 and 2 and the regulation of porcine coronary artery contractility: a role for distinct tyrosine kinase pathways. British Journal of Pharmacology. 171: 2413-25. PMID 24506284 DOI: 10.1111/Bph.12593 |
0.374 |
|
| 2014 |
Hollenberg MD, Mihara K, Polley D, Suen JY, Han A, Fairlie DP, Ramachandran R. Biased signalling and proteinase-activated receptors (PARs): targeting inflammatory disease. British Journal of Pharmacology. 171: 1180-94. PMID 24354792 DOI: 10.1111/Bph.12544 |
0.463 |
|
| 2014 |
Oikonomopoulou K, Hansen KK, Chapman K, Vergnolle N, Diamandis EP, Hollenberg MD. Kallikrein-mediated activation of PARs in inflammation and nociception Inflammation Research. 56: S499-S502. DOI: 10.1007/Bf03353889 |
0.44 |
|
| 2013 |
Stanton MM, Nelson LK, Benediktsson H, Hollenberg MD, Buret AG, Ceri H. Proteinase-activated receptor-1 and immunomodulatory effects of a PAR1-activating peptide in a mouse model of prostatitis. Mediators of Inflammation. 2013: 748395. PMID 24459330 DOI: 10.1155/2013/748395 |
0.311 |
|
| 2013 |
Chung H, Ramachandran R, Hollenberg MD, Muruve DA. Proteinase-activated receptor-2 transactivation of epidermal growth factor receptor and transforming growth factor-β receptor signaling pathways contributes to renal fibrosis. The Journal of Biological Chemistry. 288: 37319-31. PMID 24253040 DOI: 10.1074/Jbc.M113.492793 |
0.411 |
|
| 2013 |
Sharma N, Fahr J, Renaux B, Saifeddine M, Kumar R, Nishikawa S, Mihara K, Ramachandran R, Hollenberg MD, Rancourt DE. Implantation serine proteinase 2 is a monomeric enzyme with mixed serine proteolytic activity and can silence signalling via proteinase activated receptors. Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire. 91: 487-97. PMID 24219291 DOI: 10.1139/Bcb-2013-0006 |
0.385 |
|
| 2013 |
Gieseler F, Ungefroren H, Settmacher U, Hollenberg MD, Kaufmann R. Proteinase-activated receptors (PARs) - focus on receptor-receptor-interactions and their physiological and pathophysiological impact. Cell Communication and Signaling : Ccs. 11: 86. PMID 24215724 DOI: 10.1186/1478-811X-11-86 |
0.448 |
|
| 2013 |
Davidson CE, Asaduzzaman M, Arizmendi NG, Polley D, Wu Y, Gordon JR, Hollenberg MD, Cameron L, Vliagoftis H. Proteinase-activated receptor-2 activation participates in allergic sensitization to house dust mite allergens in a murine model. Clinical and Experimental Allergy : Journal of the British Society For Allergy and Clinical Immunology. 43: 1274-85. PMID 24152160 DOI: 10.1111/Cea.12185 |
0.412 |
|
| 2013 |
Mihara K, Ramachandran R, Renaux B, Saifeddine M, Hollenberg MD. Neutrophil elastase and proteinase-3 trigger G protein-biased signaling through proteinase-activated receptor-1 (PAR1). The Journal of Biological Chemistry. 288: 32979-90. PMID 24052258 DOI: 10.1074/Jbc.M113.483123 |
0.42 |
|
| 2013 |
Oikonomopoulou K, DeAngelis RA, Chen H, Diamandis EP, Hollenberg MD, Ricklin D, Lambris JD. Induction of complement C3a receptor responses by kallikrein-related peptidase 14. Journal of Immunology (Baltimore, Md. : 1950). 191: 3858-66. PMID 24014879 DOI: 10.4049/Jimmunol.1202999 |
0.385 |
|
| 2013 |
Ramachandran R, Hyun E, Zhao L, Lapointe TK, Chapman K, Hirota CL, Ghosh S, McKemy DD, Vergnolle N, Beck PL, Altier C, Hollenberg MD. TRPM8 activation attenuates inflammatory responses in mouse models of colitis. Proceedings of the National Academy of Sciences of the United States of America. 110: 7476-81. PMID 23596210 DOI: 10.1073/Pnas.1217431110 |
0.402 |
|
| 2013 |
Fernández-Blanco JA, Fernández-Blanco JA, Hollenberg MD, Martínez V, Vergara P. PAR-2-mediated control of barrier function and motility differs between early and late phases of postinfectious gut dysfunction in the rat. American Journal of Physiology. Gastrointestinal and Liver Physiology. 304: G390-400. PMID 23238933 DOI: 10.1152/Ajpgi.00387.2012 |
0.333 |
|
| 2012 |
Hollenberg MD. CSCI/RCPSC Henry Friesen Lecture. Mentors and the butterfly effect: triggers for discovering signalling by proteinases via proteinase-activated receptors (PARs) and more. Clinical and Investigative Medicine. Mã©Decine Clinique Et Experimentale. 35: E378-91. PMID 23217564 DOI: 10.25011/Cim.V35I6.19210 |
0.434 |
|
| 2012 |
Nichols HL, Saffeddine M, Theriot BS, Hegde A, Polley D, El-Mays T, Vliagoftis H, Hollenberg MD, Wilson EH, Walker JK, DeFea KA. β-Arrestin-2 mediates the proinflammatory effects of proteinase-activated receptor-2 in the airway. Proceedings of the National Academy of Sciences of the United States of America. 109: 16660-5. PMID 23012429 DOI: 10.1073/Pnas.1208881109 |
0.36 |
|
| 2012 |
Jijon HB, Buret A, Hirota CL, Hollenberg MD, Beck PL. The EGF receptor and HER2 participate in TNF-α-dependent MAPK activation and IL-8 secretion in intestinal epithelial cells. Mediators of Inflammation. 2012: 207398. PMID 22988345 DOI: 10.1155/2012/207398 |
0.34 |
|
| 2012 |
Hirota CL, Moreau F, Iablokov V, Dicay M, Renaux B, Hollenberg MD, MacNaughton WK. Epidermal growth factor receptor transactivation is required for proteinase-activated receptor-2-induced COX-2 expression in intestinal epithelial cells. American Journal of Physiology. Gastrointestinal and Liver Physiology. 303: G111-9. PMID 22517768 DOI: 10.1152/Ajpgi.00358.2011 |
0.432 |
|
| 2012 |
Ramachandran R, Eissa A, Mihara K, Oikonomopoulou K, Saifeddine M, Renaux B, Diamandis E, Hollenberg MD. Proteinase-activated receptors (PARs): differential signalling by kallikrein-related peptidases KLK8 and KLK14. Biological Chemistry. 393: 421-7. PMID 22505524 DOI: 10.1515/Hsz-2011-0251 |
0.436 |
|
| 2012 |
Chung H, Hamza M, Oikonomopoulou K, Gratio V, Saifeddine M, Virca GD, Diamandis EP, Hollenberg MD, Darmoul D. Kallikrein-related peptidase signaling in colon carcinoma cells: targeting proteinase-activated receptors. Biological Chemistry. 393: 413-20. PMID 22505523 DOI: 10.1515/Bc-2011-231 |
0.433 |
|
| 2012 |
Kaufmann R, Hollenberg MD. Proteinase-activated receptors (PARs) and calcium signaling in cancer. Advances in Experimental Medicine and Biology. 740: 979-1000. PMID 22453980 DOI: 10.1007/978-94-007-2888-2_45 |
0.367 |
|
| 2012 |
Ramachandran R, Noorbakhsh F, Defea K, Hollenberg MD. Targeting proteinase-activated receptors: therapeutic potential and challenges. Nature Reviews. Drug Discovery. 11: 69-86. PMID 22212680 DOI: 10.1038/Nrd3615 |
0.433 |
|
| 2012 |
Takei-Taniguchi R, Imai Y, Ishikawa C, Sakaguchi Y, Nakagawa N, Tsuda T, Hollenberg MD, Yamanishi K. Interleukin-17- and protease-activated receptor 2-mediated production of CXCL1 and CXCL8 modulated by cyclosporine A, vitamin D3 and glucocorticoids in human keratinocytes. The Journal of Dermatology. 39: 625-31. PMID 22211698 DOI: 10.1111/J.1346-8138.2011.01462.X |
0.387 |
|
| 2012 |
Rievaj J, Davidson C, Nadeem A, Hollenberg M, Duszyk M, Vliagoftis H. Allergic sensitization enhances anion current responsiveness of murine trachea to PAR-2 activation. Pflã¼Gers Archiv : European Journal of Physiology. 463: 497-509. PMID 22170096 DOI: 10.1007/S00424-011-1064-9 |
0.382 |
|
| 2012 |
Hollenberg MD. Novel insights into the delayed vasospasm following subarachnoid haemorrhage: importance of proteinase signalling. British Journal of Pharmacology. 165: 103-5. PMID 21718303 DOI: 10.1111/J.1476-5381.2011.01564.X |
0.363 |
|
| 2011 |
Sharma N, Kumar R, Renaux B, Saifeddine M, Nishikawa S, Mihara K, Ramachandran R, Hollenberg MD, Rancourt DE. Implantation serine proteinase 1 exhibits mixed substrate specificity that silences signaling via proteinase-activated receptors. Plos One. 6: e27888. PMID 22132161 DOI: 10.1371/Journal.Pone.0027888 |
0.364 |
|
| 2011 |
Acharjee S, Zhu Y, Maingat F, Pardo C, Ballanyi K, Hollenberg MD, Power C. Proteinase-activated receptor-1 mediates dorsal root ganglion neuronal degeneration in HIV/AIDS. Brain : a Journal of Neurology. 134: 3209-21. PMID 22021895 DOI: 10.1093/Brain/Awr242 |
0.384 |
|
| 2011 |
Gratio V, Loriot C, Virca GD, Oikonomopoulou K, Walker F, Diamandis EP, Hollenberg MD, Darmoul D. Kallikrein-related peptidase 14 acts on proteinase-activated receptor 2 to induce signaling pathway in colon cancer cells. The American Journal of Pathology. 179: 2625-36. PMID 21907696 DOI: 10.1016/J.Ajpath.2011.07.016 |
0.406 |
|
| 2011 |
Ramachandran R, Mihara K, Chung H, Renaux B, Lau CS, Muruve DA, DeFea KA, Bouvier M, Hollenberg MD. Neutrophil elastase acts as a biased agonist for proteinase-activated receptor-2 (PAR2). The Journal of Biological Chemistry. 286: 24638-48. PMID 21576245 DOI: 10.1074/Jbc.M110.201988 |
0.42 |
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| 2011 |
Shpacovitch VM, Feld M, Holzinger D, Kido M, Hollenberg MD, Levi-Schaffer F, Vergnolle N, Ludwig S, Roth J, Luger T, Steinhoff M. Role of proteinase-activated receptor-2 in anti-bacterial and immunomodulatory effects of interferon-γ on human neutrophils and monocytes. Immunology. 133: 329-39. PMID 21501162 DOI: 10.1111/J.1365-2567.2011.03443.X |
0.391 |
|
| 2011 |
Adams MN, Ramachandran R, Yau MK, Suen JY, Fairlie DP, Hollenberg MD, Hooper JD. Structure, function and pathophysiology of protease activated receptors. Pharmacology & Therapeutics. 130: 248-82. PMID 21277892 DOI: 10.1016/J.Pharmthera.2011.01.003 |
0.448 |
|
| 2011 |
Arizmendi NG, Abel M, Mihara K, Davidson C, Polley D, Nadeem A, El Mays T, Gilmore BF, Walker B, Gordon JR, Hollenberg MD, Vliagoftis H. Mucosal allergic sensitization to cockroach allergens is dependent on proteinase activity and proteinase-activated receptor-2 activation. Journal of Immunology (Baltimore, Md. : 1950). 186: 3164-72. PMID 21270400 DOI: 10.4049/Jimmunol.0903812 |
0.378 |
|
| 2011 |
Goldblum SE, Rai U, Tripathi A, Thakar M, De Leo L, Di Toro N, Not T, Ramachandran R, Puche AC, Hollenberg MD, Fasano A. The active Zot domain (aa 288-293) increases ZO-1 and myosin 1C serine/threonine phosphorylation, alters interaction between ZO-1 and its binding partners, and induces tight junction disassembly through proteinase activated receptor 2 activation. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 25: 144-58. PMID 20852064 DOI: 10.1096/Fj.10-158972 |
0.401 |
|
| 2011 |
Davidson C, Polley D, Asaduzzaman M, Arizmendi N, Gordon JR, Hollenberg MD, Vliagoftis H. Role of proteinase-activated receptor-2 in allergic sensitization to house dust mite allergens Allergy, Asthma & Clinical Immunology. 7. DOI: 10.1186/1710-1492-7-S2-A30 |
0.326 |
|
| 2011 |
Hyun E, Ramachandran R, Hollenberg MD. Icilin, an Agonist Cold Activated Transient Receptor Potential (TRP) Channels Protects Mice Against Colitis Gastroenterology. 140: S-840. DOI: 10.1016/S0016-5085(11)63485-9 |
0.348 |
|
| 2011 |
Houle S, Hollenberg MD. PAR4 proteinase-activated receptor Xpharm: the Comprehensive Pharmacology Reference. 1-15. DOI: 10.1016/B978-008055232-3.60342-3 |
0.324 |
|
| 2011 |
Houle S, Hollenberg MD. PAR3 proteinase-activated receptor Xpharm: the Comprehensive Pharmacology Reference. 1-13. DOI: 10.1016/B978-008055232-3.60341-1 |
0.324 |
|
| 2011 |
Houle S, Hollenberg MD. PAR2 proteinase-activated receptor Xpharm: the Comprehensive Pharmacology Reference. 1-13. DOI: 10.1016/B978-008055232-3.60340-X |
0.324 |
|
| 2011 |
Houle S, Hollenberg MD. Par1 proteinase-activated receptor Xpharm: the Comprehensive Pharmacology Reference. 1-18. DOI: 10.1016/B978-008055232-3.60339-3 |
0.324 |
|
| 2010 |
Wang J, Boerma M, Kulkarni A, Hollenberg MD, Hauer-Jensen M. Activation of protease activated receptor 2 by exogenous agonist exacerbates early radiation injury in rat intestine. International Journal of Radiation Oncology, Biology, Physics. 77: 1206-12. PMID 20610041 DOI: 10.1016/J.Ijrobp.2009.12.075 |
0.399 |
|
| 2010 |
Blanco I, Béritze N, Argüelles M, Cárcaba V, Fernández F, Janciauskiene S, Oikonomopoulou K, de Serres FJ, Fernández-Bustillo E, Hollenberg MD. Abnormal overexpression of mastocytes in skin biopsies of fibromyalgia patients. Clinical Rheumatology. 29: 1403-12. PMID 20428906 DOI: 10.1007/S10067-010-1474-7 |
0.307 |
|
| 2010 |
Hollenberg MD. Getting the message across: pathophysiology and signaling via receptors for polypeptide hormones and proteinases. Clinical and Investigative Medicine. Mã©Decine Clinique Et Experimentale. 33: E133. PMID 20370993 DOI: 10.25011/Cim.V33I2.12352 |
0.419 |
|
| 2010 |
Oikonomopoulou K, Batruch I, Smith CR, Soosaipillai A, Diamandis EP, Hollenberg MD. Functional proteomics of kallikrein-related peptidases in ovarian cancer ascites fluid. Biological Chemistry. 391: 381-90. PMID 20180649 DOI: 10.1515/Bc.2010.045 |
0.308 |
|
| 2010 |
Oikonomopoulou K, Diamandis EP, Hollenberg MD. Kallikrein-related peptidases: proteolysis and signaling in cancer, the new frontier. Biological Chemistry. 391: 299-310. PMID 20180639 DOI: 10.1515/Bc.2010.038 |
0.438 |
|
| 2010 |
Al-Ani B, Hewett PW, Cudmore MJ, Fujisawa T, Saifeddine M, Williams H, Ramma W, Sissaoui S, Jayaraman PS, Ohba M, Ahmad S, Hollenberg MD, Ahmed A. Activation of proteinase-activated receptor 2 stimulates soluble vascular endothelial growth factor receptor 1 release via epidermal growth factor receptor transactivation in endothelial cells. Hypertension. 55: 689-97. PMID 20124108 DOI: 10.1161/Hypertensionaha.109.136333 |
0.423 |
|
| 2010 |
Hyun E, Ramachandran R, Cenac N, Houle S, Rousset P, Saxena A, Liblau RS, Hollenberg MD, Vergnolle N. Insulin modulates protease-activated receptor 2 signaling: implications for the innate immune response. Journal of Immunology (Baltimore, Md. : 1950). 184: 2702-9. PMID 20118282 DOI: 10.4049/Jimmunol.0902171 |
0.366 |
|
| 2010 |
Georgy SR, Pagel CN, Wong DM, Sivagurunathan S, Loh LH, Myers DE, Hollenberg MD, Pike RN, Mackie EJ. Proteinase-activated receptor-2 (PAR2) and mouse osteoblasts: regulation of cell function and lack of specificity of PAR2-activating peptides. Clinical and Experimental Pharmacology & Physiology. 37: 328-36. PMID 19769607 DOI: 10.1111/J.1440-1681.2009.05294.X |
0.41 |
|
| 2010 |
Androutsou ME, Saifeddine M, Hollenberg MD, Matsoukas J, Agelis G. Design, synthesis and biological evaluation of non-peptide PAR1 thrombin receptor antagonists based on small bifunctional templates: arginine and phenylalanine side chain groups are keys for receptor activity. Amino Acids. 38: 985-90. PMID 19484400 DOI: 10.1007/S00726-009-0306-Z |
0.422 |
|
| 2010 |
Gratio V, Loriot C, Oikonomopoulou K, Chung H, Diamandi EP, Hollenberg MD, Darmoul D. Abstract 4104: Protease-activated receptor 2, a KLK14 target in colon cancer cells Cancer Research. 70: 4104-4104. DOI: 10.1158/1538-7445.Am10-4104 |
0.387 |
|
| 2010 |
Jijon H, Buret AG, Hirota CL, Hollenberg MD, Beck PL. M1796 TGF-Alpha Autocrine Signaling is a Key Step in TNF-Alpha-Stimulated Proinflammatory Signaling in Intestinal Epithelial Cells Gastroenterology. 138: S-421. DOI: 10.1016/S0016-5085(10)61939-7 |
0.346 |
|
| 2009 |
Ramachandran R, Mihara K, Mathur M, Rochdi MD, Bouvier M, Defea K, Hollenberg MD. Agonist-biased signaling via proteinase activated receptor-2: differential activation of calcium and mitogen-activated protein kinase pathways. Molecular Pharmacology. 76: 791-801. PMID 19605524 DOI: 10.1124/Mol.109.055509 |
0.424 |
|
| 2009 |
Kaufmann R, Oettel C, Horn A, Halbhuber KJ, Eitner A, Krieg R, Katenkamp K, Henklein P, Westermann M, Böhmer FD, Ramachandran R, Saifeddine M, Hollenberg MD, Settmacher U. Met receptor tyrosine kinase transactivation is involved in proteinase-activated receptor-2-mediated hepatocellular carcinoma cell invasion. Carcinogenesis. 30: 1487-96. PMID 19546160 DOI: 10.1093/Carcin/Bgp153 |
0.372 |
|
| 2009 |
Swystun VA, Renaux B, Moreau F, Wen S, Peplowski MA, Hollenberg MD, MacNaughton WK. Serine proteases decrease intestinal epithelial ion permeability by activation of protein kinase Czeta. American Journal of Physiology. Gastrointestinal and Liver Physiology. 297: G60-70. PMID 19460843 DOI: 10.1152/Ajpgi.00096.2009 |
0.391 |
|
| 2009 |
Pittman QJ, Hollenberg MD. Urotensin I-CRF-Urocortins: a mermaid's tail. General and Comparative Endocrinology. 164: 7-14. PMID 19409389 DOI: 10.1016/J.Ygcen.2009.04.024 |
0.302 |
|
| 2009 |
Xue M, Hollenberg MD, Demchuk A, Yong VW. Relative importance of proteinase-activated receptor-1 versus matrix metalloproteinases in intracerebral hemorrhage-mediated neurotoxicity in mice. Stroke; a Journal of Cerebral Circulation. 40: 2199-204. PMID 19359644 DOI: 10.1161/Strokeaha.108.540393 |
0.348 |
|
| 2009 |
Wilson BJ, Harada R, LeDuy L, Hollenberg MD, Nepveu A. CUX1 transcription factor is a downstream effector of the proteinase-activated receptor 2 (PAR2). The Journal of Biological Chemistry. 284: 36-45. PMID 18952606 DOI: 10.1074/Jbc.M803808200 |
0.417 |
|
| 2008 |
Hansen KK, Oikonomopoulou K, Baruch A, Ramachandran R, Beck P, Diamandis EP, Hollenberg MD. Proteinases as hormones: targets and mechanisms for proteolytic signaling. Biological Chemistry. 389: 971-82. PMID 18979623 DOI: 10.1515/Bc.2008.120 |
0.458 |
|
| 2008 |
Hollenberg MD, Oikonomopoulou K, Hansen KK, Saifeddine M, Ramachandran R, Diamandis EP. Kallikreins and proteinase-mediated signaling: proteinase-activated receptors (PARs) and the pathophysiology of inflammatory diseases and cancer. Biological Chemistry. 389: 643-51. PMID 18627296 DOI: 10.1515/Bc.2008.077 |
0.463 |
|
| 2008 |
Rallabhandi P, Nhu QM, Toshchakov VY, Piao W, Medvedev AE, Hollenberg MD, Fasano A, Vogel SN. Analysis of proteinase-activated receptor 2 and TLR4 signal transduction: a novel paradigm for receptor cooperativity. The Journal of Biological Chemistry. 283: 24314-25. PMID 18622013 DOI: 10.1074/Jbc.M804800200 |
0.446 |
|
| 2008 |
Hollenberg MD, Renaux B, Hyun E, Houle S, Vergnolle N, Saifeddine M, Ramachandran R. Derivatized 2-furoyl-LIGRLO-amide, a versatile and selective probe for proteinase-activated receptor 2: binding and visualization. The Journal of Pharmacology and Experimental Therapeutics. 326: 453-62. PMID 18477767 DOI: 10.1124/Jpet.108.136432 |
0.418 |
|
| 2008 |
Feld M, Shpacovitch VM, Ehrhardt C, Kerkhoff C, Hollenberg MD, Vergnolle N, Ludwig S, Steinhoff M. Agonists of proteinase-activated receptor-2 enhance IFN-gamma-inducible effects on human monocytes: role in influenza A infection. Journal of Immunology (Baltimore, Md. : 1950). 180: 6903-10. PMID 18453611 DOI: 10.4049/Jimmunol.180.10.6903 |
0.343 |
|
| 2008 |
Yamada S, Ehlert FJ, Hollenberg MD. 5th International Symposium on receptor mechanisms, signal transduction and drug effects. Naunyn-Schmiedeberg's Archives of Pharmacology. 377: 267-8. PMID 18357439 DOI: 10.1007/S00210-008-0273-Z |
0.34 |
|
| 2008 |
Shpacovitch V, Feld M, Hollenberg MD, Luger TA, Steinhoff M. Role of protease-activated receptors in inflammatory responses, innate and adaptive immunity. Journal of Leukocyte Biology. 83: 1309-22. PMID 18347074 DOI: 10.1189/Jlb.0108001 |
0.39 |
|
| 2008 |
Ramachandran R, Hollenberg MD. Proteinases and signalling: pathophysiological and therapeutic implications via PARs and more. British Journal of Pharmacology. 153: S263-82. PMID 18059329 DOI: 10.1038/Sj.Bjp.0707507 |
0.457 |
|
| 2008 |
van der Merwe JQ, Hollenberg MD, MacNaughton WK. EGF receptor transactivation and MAP kinase mediate proteinase-activated receptor-2-induced chloride secretion in intestinal epithelial cells. American Journal of Physiology. Gastrointestinal and Liver Physiology. 294: G441-51. PMID 18032480 DOI: 10.1152/Ajpgi.00303.2007 |
0.415 |
|
| 2008 |
Wang H, Wen S, Bunnett NW, Leduc R, Hollenberg MD, MacNaughton WK. Proteinase-activated receptor-2 induces cyclooxygenase-2 expression through beta-catenin and cyclic AMP-response element-binding protein. The Journal of Biological Chemistry. 283: 809-15. PMID 17962194 DOI: 10.1074/Jbc.M703021200 |
0.347 |
|
| 2008 |
Hansen KK, Oikonomopoulou K, Li Y, Hollenberg MD. Proteinases, proteinase-activated receptors (PARs) and the pathophysiology of cancer and diseases of the cardiovascular, musculoskeletal, nervous and gastrointestinal systems. Naunyn-Schmiedeberg's Archives of Pharmacology. 377: 377-92. PMID 17952408 DOI: 10.1007/S00210-007-0194-2 |
0.462 |
|
| 2008 |
Vergnolle N, Bunnett NW, Wallace JL, Hollenberg MD. Role of proteinases and proteinase-activated receptors in pain pathways Journal of Neurochemistry. 81: 114-114. DOI: 10.1046/J.1471-4159.81.S1.112.X |
0.406 |
|
| 2007 |
Afkhami-Goli A, Noorbakhsh F, Keller AJ, Vergnolle N, Westaway D, Jhamandas JH, Andrade-Gordon P, Hollenberg MD, Arab H, Dyck RH, Power C. Proteinase-activated receptor-2 exerts protective and pathogenic cell type-specific effects in Alzheimer's disease. Journal of Immunology (Baltimore, Md. : 1950). 179: 5493-503. PMID 17911636 DOI: 10.4049/Jimmunol.179.8.5493 |
0.364 |
|
| 2007 |
Shpacovitch VM, Seeliger S, Huber-Lang M, Balkow S, Feld M, Hollenberg MD, Sarma VJ, Ward PA, Strey A, Gerke V, Sommerhoff CP, Vergnolle N, Steinhoff M. Agonists of proteinase-activated receptor-2 affect transendothelial migration and apoptosis of human neutrophils. Experimental Dermatology. 16: 799-806. PMID 17845211 DOI: 10.1111/J.1600-0625.2007.00605.X |
0.415 |
|
| 2007 |
Saifeddine M, Seymour ML, Xiao YP, Compton SJ, Houle S, Ramachandran R, MacNaughton WK, Simonet S, Vayssettes-Courchay C, Verbeuren TJ, Hollenberg MD. Proteinase-activated receptor-2 activating peptides: distinct canine coronary artery receptor systems. American Journal of Physiology. Heart and Circulatory Physiology. 293: H3279-89. PMID 17766477 DOI: 10.1152/Ajpheart.00519.2007 |
0.384 |
|
| 2007 |
Ebeling C, Lam T, Gordon JR, Hollenberg MD, Vliagoftis H. Proteinase-activated receptor-2 promotes allergic sensitization to an inhaled antigen through a TNF-mediated pathway. Journal of Immunology (Baltimore, Md. : 1950). 179: 2910-7. PMID 17709505 DOI: 10.4049/Jimmunol.179.5.2910 |
0.355 |
|
| 2007 |
Knecht W, Cottrell GS, Amadesi S, Mohlin J, Skåregärde A, Gedda K, Peterson A, Chapman K, Hollenberg MD, Vergnolle N, Bunnett NW. Trypsin IV or mesotrypsin and p23 cleave protease-activated receptors 1 and 2 to induce inflammation and hyperalgesia. The Journal of Biological Chemistry. 282: 26089-100. PMID 17623652 DOI: 10.1074/Jbc.M703840200 |
0.389 |
|
| 2007 |
Kaufmann R, Rahn S, Pollrich K, Hertel J, Dittmar Y, Hommann M, Henklein P, Biskup C, Westermann M, Hollenberg MD, Settmacher U. Thrombin-mediated hepatocellular carcinoma cell migration: cooperative action via proteinase-activated receptors 1 and 4. Journal of Cellular Physiology. 211: 699-707. PMID 17323377 DOI: 10.1002/Jcp.21027 |
0.388 |
|
| 2007 |
Ebeling C, Lam T, Gordon J, Vliagoftis H, Hollenberg M. Proteinase-activated Receptor-2 (PAR-2) Activation Promotes Allergic Sensitization and Prevents the Development of Immune Tolerance to Inhaled Antigens Through a TNF Mediated Pathway Clinical Immunology. 123: S73. DOI: 10.1016/J.Clim.2007.03.383 |
0.387 |
|
| 2006 |
Vergote D, Butler GS, Ooms M, Cox JH, Silva C, Hollenberg MD, Jhamandas JH, Overall CM, Power C. Proteolytic processing of SDF-1alpha reveals a change in receptor specificity mediating HIV-associated neurodegeneration. Proceedings of the National Academy of Sciences of the United States of America. 103: 19182-7. PMID 17148615 DOI: 10.1073/Pnas.0604678103 |
0.381 |
|
| 2006 |
Oikonomopoulou K, Hansen KK, Saifeddine M, Tea I, Blaber M, Blaber SI, Scarisbrick I, Andrade-Gordon P, Cottrell GS, Bunnett NW, Diamandis EP, Hollenberg MD. Proteinase-activated receptors, targets for kallikrein signaling. The Journal of Biological Chemistry. 281: 32095-112. PMID 16885167 DOI: 10.1074/Jbc.M513138200 |
0.452 |
|
| 2006 |
Vergnolle N, Cellars L, Mencarelli A, Rizzo G, Swaminathan S, Beck P, Steinhoff M, Andrade-Gordon P, Bunnett NW, Hollenberg MD, Wallace JL, Cirino G, Fiorucci S. A role for proteinase-activated receptor-1 in inflammatory bowel diseases. The Journal of Clinical Investigation. 116: 2056. PMID 16881139 DOI: 10.1172/Jci21689R1 |
0.381 |
|
| 2006 |
Oikonomopoulou K, Hansen KK, Saifeddine M, Vergnolle N, Tea I, Blaber M, Blaber SI, Scarisbrick I, Diamandis EP, Hollenberg MD. Kallikrein-mediated cell signalling: targeting proteinase-activated receptors (PARs). Biological Chemistry. 387: 817-24. PMID 16800746 DOI: 10.1515/Bc.2006.104 |
0.442 |
|
| 2006 |
Oikonomopoulou K, Hansen KK, Saifeddine M, Vergnolle N, Tea I, Diamandis EP, Hollenberg MD. Proteinase-mediated cell signalling: targeting proteinase-activated receptors (PARs) by kallikreins and more. Biological Chemistry. 387: 677-85. PMID 16800728 DOI: 10.1515/Bc.2006.086 |
0.479 |
|
| 2006 |
Bergmann S, Junker K, Henklein P, Hollenberg MD, Settmacher U, Kaufmann R. PAR-type thrombin receptors in renal carcinoma cells: PAR1-mediated EGFR activation promotes cell migration. Oncology Reports. 15: 889-93. PMID 16525676 DOI: 10.3892/Or.15.4.889 |
0.406 |
|
| 2006 |
Noorbakhsh F, Tsutsui S, Vergnolle N, Boven LA, Shariat N, Vodjgani M, Warren KG, Andrade-Gordon P, Hollenberg MD, Power C. Proteinase-activated receptor 2 modulates neuroinflammation in experimental autoimmune encephalomyelitis and multiple sclerosis. The Journal of Experimental Medicine. 203: 425-35. PMID 16476770 DOI: 10.1084/Jem.20052148 |
0.317 |
|
| 2006 |
Adam E, Hansen KK, Astudillo Fernandez O, Astudillo OF, Coulon L, Bex F, Duhant X, Jaumotte E, Hollenberg MD, Jacquet A. The house dust mite allergen Der p 1, unlike Der p 3, stimulates the expression of interleukin-8 in human airway epithelial cells via a proteinase-activated receptor-2-independent mechanism. The Journal of Biological Chemistry. 281: 6910-23. PMID 16293628 DOI: 10.1074/Jbc.M507140200 |
0.335 |
|
| 2006 |
Kelso EB, Lockhart JC, Hembrough T, Dunning L, Plevin R, Hollenberg MD, Sommerhoff CP, McLean JS, Ferrell WR. Therapeutic promise of proteinase-activated receptor-2 antagonism in joint inflammation Journal of Pharmacology and Experimental Therapeutics. 316: 1017-1024. PMID 16260582 DOI: 10.1124/Jpet.105.093807 |
0.396 |
|
| 2006 |
Brown JK, Hollenberg MD, Jones CA. Tryptase activates phosphatidylinositol 3-kinases proteolytically independently from proteinase-activated receptor-2 in cultured dog airway smooth muscle cells. American Journal of Physiology. Lung Cellular and Molecular Physiology. 290: L259-69. PMID 16155087 DOI: 10.1152/Ajplung.00215.2005 |
0.379 |
|
| 2005 |
Hollenberg MD, Houle S. Proteinases as hormone-like signal messengers: Proteinase-activated receptors and the pathophysiology of inflammation, pain, cardiovascular disease and cancer Swiss Medical Weekly. 135: 425-432. PMID 16208579 |
0.341 |
|
| 2005 |
Kawao N, Nagataki M, Nagasawa K, Kubo S, Cushing K, Wada T, Sekiguchi F, Ichida S, Hollenberg MD, MacNaughton WK, Nishikawa H, Kawabata A. Signal transduction for proteinase-activated receptor-2-triggered prostaglandin E2 formation in human lung epithelial cells Journal of Pharmacology and Experimental Therapeutics. 315: 576-589. PMID 16120814 DOI: 10.1124/Jpet.105.089490 |
0.389 |
|
| 2005 |
Cenac N, Cellars L, Steinhoff M, Andrade-Gordon P, Hollenberg MD, Wallace JL, Fiorucci S, Vergnolle N. Proteinase-activated receptor-1 is an anti-inflammatory signal for colitis mediated by a type 2 immune response. Inflammatory Bowel Diseases. 11: 792-8. PMID 16116312 DOI: 10.1097/01.Mib.0000177506.71784.Bd |
0.408 |
|
| 2005 |
Houle S, Papez MD, Ferazzini M, Hollenberg MD, Vergnolle N. Neutrophils and the kallikrein-kinin system in proteinase-activated receptor 4-mediated inflammation in rodents British Journal of Pharmacology. 146: 670-678. PMID 16100525 DOI: 10.1038/Sj.Bjp.0706371 |
0.441 |
|
| 2005 |
Seymour ML, Binion DG, Compton SJ, Hollenberg MD, MacNaughton WK. Expression of proteinase-activated receptor 2 on human primary gastrointestinal myofibroblasts and stimulation of prostaglandin synthesis Canadian Journal of Physiology and Pharmacology. 83: 605-616. PMID 16091786 DOI: 10.1139/Y05-046 |
0.403 |
|
| 2005 |
Massi D, Naldini A, Ardinghi C, Carraro F, Franchi A, Paglierani M, Tarantini F, Ketabchi S, Cirino G, Hollenberg MD, Geppetti P, Santucci M. Expression of protease-activated receptors 1 and 2 in melanocytic nevi and malignant melanoma Human Pathology. 36: 676-685. PMID 16021575 DOI: 10.1016/J.Humpath.2005.04.008 |
0.347 |
|
| 2005 |
Hansen KK, Sherman PM, Cellars L, Andrade-Gordon P, Pan Z, Baruch A, Wallace JL, Hollenberg MD, Vergnolle N. A major role for proteolytic activity and proteinase-activated receptor-2 in the pathogenesis of infectious colitis. Proceedings of the National Academy of Sciences of the United States of America. 102: 8363-8. PMID 15919826 DOI: 10.1073/Pnas.0409535102 |
0.314 |
|
| 2005 |
Noorbakhsh F, Vergnolle N, McArthur JC, Silva C, Vodjgani M, Andrade-Gordon P, Hollenberg MD, Power C. Proteinase-activated receptor-2 induction by neuroinflammation prevents neuronal death during HIV infection Journal of Immunology. 174: 7320-7329. PMID 15905579 DOI: 10.4049/Jimmunol.174.11.7320 |
0.316 |
|
| 2005 |
Suzuki T, Moraes TJ, Vachon E, Ginzberg HH, Huang TT, Matthay MA, Hollenberg MD, Marshall J, McCulloch CA, Abreu MT, Chow CW, Downey GP. Proteinase-activated receptor-1 mediates elastase-induced apoptosis of human lung epithelial cells. American Journal of Respiratory Cell and Molecular Biology. 33: 231-47. PMID 15891109 DOI: 10.1165/Rcmb.2005-0109Oc |
0.345 |
|
| 2005 |
Ebeling C, Forsythe P, Ng J, Gordon JR, Hollenberg M, Vliagoftis H. Proteinase-activated receptor 2 activation in the airways enhances antigen-mediated airway inflammation and airway hyperresponsiveness through different pathways. The Journal of Allergy and Clinical Immunology. 115: 623-30. PMID 15753914 DOI: 10.1016/J.Jaci.2004.11.042 |
0.361 |
|
| 2005 |
Dulon S, Leduc D, Cottrell GS, D'Alayer J, Hansen KK, Bunnett NW, Hollenberg MD, Pidard D, Chignard M. Pseudomonas aeruginosa elastase disables proteinase-activated receptor 2 in respiratory epithelial cells. American Journal of Respiratory Cell and Molecular Biology. 32: 411-9. PMID 15705968 DOI: 10.1165/Rcmb.2004-0274Oc |
0.44 |
|
| 2005 |
Steinhoff M, Buddenkotte J, Shpacovitch V, Rattenholl A, Moormann C, Vergnolle N, Luger TA, Hollenberg MD. Proteinase-activated receptors: Transducers of proteinase-mediated signaling in inflammation and immune response Endocrine Reviews. 26: 1-43. PMID 15689571 DOI: 10.1210/Er.2003-0025 |
0.435 |
|
| 2005 |
Hollenberg MD. Physiology and pathophysiology of proteinase-activated receptors (PARs): Proteinases as hormone-like signal messengers: PARs and more Journal of Pharmacological Sciences. 97: 8-13. PMID 15665444 DOI: 10.1254/Jphs.Fmj04005X2 |
0.469 |
|
| 2005 |
Ma L, Perini R, McKnight W, Dicay M, Klein A, Hollenberg MD, Wallace JL. Proteinase-activated receptors 1 and 4 counter-regulate endostatin and VEGF release from human platelets. Proceedings of the National Academy of Sciences of the United States of America. 102: 216-20. PMID 15615851 DOI: 10.1073/Pnas.0406682102 |
0.347 |
|
| 2005 |
Buresi MC, Vergnolle N, Sharkey KA, Keenan CM, Andrade-Gordon P, Cirino G, Cirillo D, Hollenberg MD, MacNaughton WK. Activation of proteinase-activated receptor-1 inhibits neurally evoked chloride secretion in the mouse colon in vitro. American Journal of Physiology. Gastrointestinal and Liver Physiology. 288: G337-45. PMID 15345469 DOI: 10.1152/Ajpgi.00112.2004 |
0.461 |
|
| 2005 |
Wang X, Hollenberg MD, Loutzenhiser R. Redundant signaling mechanisms contribute to the vasodilatory response of the afferent arteriole to proteinase-activated receptor-2 American Journal of Physiology - Renal Physiology. 288: F65-F75. PMID 15328067 DOI: 10.1152/Ajprenal.00194.2004 |
0.352 |
|
| 2004 |
McGuire JJ, Hollenberg MD, Bennett BM, Triggle CR. Hyperpolarization of murine small caliber mesenteric arteries by activation of endothelial proteinase-activated receptor 2. Canadian Journal of Physiology and Pharmacology. 82: 1103-12. PMID 15644953 DOI: 10.1139/Y04-121 |
0.342 |
|
| 2004 |
Vergnolle N, Cellars L, Mencarelli A, Rizzo G, Swaminathan S, Beck P, Steinhoff M, Andrade-Gordon P, Bunnett NW, Hollenberg MD, Wallace JL, Cirino G, Fiorucci S. A role for proteinase-activated receptor-1 in inflammatory bowel diseases. The Journal of Clinical Investigation. 114: 1444-56. PMID 15545995 DOI: 10.1172/Jci21689 |
0.409 |
|
| 2004 |
Hollenberg MD, Saifeddine M, Sandhu S, Houle S, Vergnolle N. Proteinase-activated receptor-4: evaluation of tethered ligand-derived peptides as probes for receptor function and as inflammatory agonists in vivo. British Journal of Pharmacology. 143: 443-54. PMID 15451771 DOI: 10.1038/Sj.Bjp.0705946 |
0.416 |
|
| 2004 |
Chan AK, Vergnolle N, Hollenberg MD, von der Weid PY. Proteinase-activated receptor 2 activation modulates guinea-pig mesenteric lymphatic vessel pacemaker potential and contractile activity. The Journal of Physiology. 560: 563-76. PMID 15331674 DOI: 10.1113/Jphysiol.2004.071399 |
0.41 |
|
| 2004 |
Alshurafa HN, Stenton GR, Wallace JL, Hollenberg MD, Befus AD, Vliagoftis H. A protease activated receptor-2 (PAR-2) activating peptide, tc-LIGRLO-NH2, induces protease release from mast cells: role in TNF degradation. Bmc Pharmacology. 4: 12. PMID 15265236 DOI: 10.1186/1471-2210-4-12 |
0.468 |
|
| 2004 |
Kawabata A, Kubo S, Ishiki T, Kawao N, Sekiguchi F, Kuroda R, Hollenberg MD, Kanke T, Saito N. Proteinase-activated receptor-2-mediated relaxation in mouse tracheal and bronchial smooth muscle: signal transduction mechanisms and distinct agonist sensitivity. The Journal of Pharmacology and Experimental Therapeutics. 311: 402-10. PMID 15199093 DOI: 10.1124/Jpet.104.068387 |
0.407 |
|
| 2004 |
Shpacovitch VM, Varga G, Strey A, Gunzer M, Mooren F, Buddenkotte J, Vergnolle N, Sommerhoff CP, Grabbe S, Gerke V, Homey B, Hollenberg M, Luger TA, Steinhoff M. Agonists of proteinase-activated receptor-2 modulate human neutrophil cytokine secretion, expression of cell adhesion molecules, and migration within 3-D collagen lattices. Journal of Leukocyte Biology. 76: 388-98. PMID 15155775 DOI: 10.1189/Jlb.0503221 |
0.434 |
|
| 2004 |
Hansen KK, Saifeddine M, Hollenberg MD. Tethered ligand-derived peptides of proteinase-activated receptor 3 (PAR3) activate PAR1 and PAR2 in Jurkat T cells. Immunology. 112: 183-90. PMID 15147561 DOI: 10.1111/J.1365-2567.2004.01870.X |
0.421 |
|
| 2004 |
Napoli C, de Nigris F, Wallace JL, Hollenberg MD, Tajana G, De Rosa G, Sica V, Cirino G. Evidence that protease activated receptor 2 expression is enhanced in human coronary atherosclerotic lesions. Journal of Clinical Pathology. 57: 513-6. PMID 15113859 DOI: 10.1136/Jcp.2003.015156 |
0.357 |
|
| 2004 |
McGuire JJ, Saifeddine M, Triggle CR, Sun K, Hollenberg MD. 2-furoyl-LIGRLO-amide: a potent and selective proteinase-activated receptor 2 agonist. The Journal of Pharmacology and Experimental Therapeutics. 309: 1124-31. PMID 14976230 DOI: 10.1124/Jpet.103.064584 |
0.435 |
|
| 2004 |
He S, Aslam A, Gaça MD, He Y, Buckley MG, Hollenberg MD, Walls AF. Inhibitors of tryptase as mast cell-stabilizing agents in the human airways: effects of tryptase and other agonists of proteinase-activated receptor 2 on histamine release. The Journal of Pharmacology and Experimental Therapeutics. 309: 119-26. PMID 14722328 DOI: 10.1124/Jpet.103.061291 |
0.387 |
|
| 2004 |
Al-Ani B, Hansen KK, Hollenberg MD. Proteinase-activated receptor-2: key role of amino-terminal dipeptide residues of the tethered ligand for receptor activation. Molecular Pharmacology. 65: 149-56. PMID 14722246 DOI: 10.1124/Mol.65.1.149 |
0.426 |
|
| 2004 |
Noorbakhsh F, Vergnolle N, Hollenberg MD, Power C. Proteinase-activated receptors in the nervous system. Nature Reviews. Neuroscience. 4: 981-90. PMID 14682360 DOI: 10.1038/Nrn1255 |
0.368 |
|
| 2004 |
Seatter MJ, Drummond R, Kanke T, Macfarlane SR, Hollenberg MD, Plevin R. The role of the C-terminal tail in protease-activated receptor-2-mediated Ca2+ signalling, proline-rich tyrosine kinase-2 activation, and mitogen-activated protein kinase activity. Cellular Signalling. 16: 21-9. PMID 14607272 DOI: 10.1016/S0898-6568(03)00095-0 |
0.42 |
|
| 2004 |
Hollenberg MD. Proteinase-mediated signaling: proteinase-activated receptors (PARs) and much more. Life Sciences. 74: 237-46. PMID 14607251 DOI: 10.1016/J.Lfs.2003.09.010 |
0.468 |
|
| 2004 |
Wang J, Zheng H, Hollenberg MD, Wijesuriya SJ, Ou X, Hauer-Jensen M. Up-regulation and activation of proteinase-activated receptor 2 in early and delayed radiation injury in the rat intestine: influence of biological activators of proteinase-activated receptor 2. Radiation Research. 160: 524-35. PMID 14565830 DOI: 10.1667/Rr3080 |
0.385 |
|
| 2003 |
Triggle CR, Hollenberg M, Anderson TJ, Ding H, Jiang Y, Ceroni L, Wiehler WB, Ng ES, Ellis A, Andrews K, McGuire JJ, Pannirselvam M. The endothelium in health and disease--a target for therapeutic intervention. Journal of Smooth Muscle Research = Nihon Heikatsukin Gakkai Kikanshi. 39: 249-67. PMID 15048017 DOI: 10.1540/Jsmr.39.249 |
0.315 |
|
| 2003 |
Nguyen C, Coelho AM, Grady E, Compton SJ, Wallace JL, Hollenberg MD, Cenac N, Garcia-Villar R, Bueno L, Steinhoff M, Bunnett NW, Vergnolle N. Colitis induced by proteinase-activated receptor-2 agonists is mediated by a neurogenic mechanism. Canadian Journal of Physiology and Pharmacology. 81: 920-7. PMID 14614531 DOI: 10.1139/Y03-080 |
0.45 |
|
| 2003 |
Chin AC, Vergnolle N, MacNaughton WK, Wallace JL, Hollenberg MD, Buret AG. Proteinase-activated receptor 1 activation induces epithelial apoptosis and increases intestinal permeability. Proceedings of the National Academy of Sciences of the United States of America. 100: 11104-9. PMID 12960392 DOI: 10.1073/Pnas.1831452100 |
0.412 |
|
| 2003 |
Gui Y, Loutzenhiser R, Hollenberg MD. Bidirectional regulation of renal hemodynamics by activation of PAR1 and PAR2 in isolated perfused rat kidney. American Journal of Physiology. Renal Physiology. 285: F95-104. PMID 12644441 DOI: 10.1152/Ajprenal.00396.2002 |
0.659 |
|
| 2003 |
Al-Ani B, Hollenberg MD. Selective tryptic cleavage at the tethered ligand site of the amino terminal domain of proteinase-activated receptor-2 in intact cells. The Journal of Pharmacology and Experimental Therapeutics. 304: 1120-8. PMID 12604689 DOI: 10.1124/Jpet.102.043844 |
0.369 |
|
| 2003 |
Klarenbach SW, Chipiuk A, Nelson RC, Hollenberg MD, Murray AG. Differential actions of PAR2 and PAR1 in stimulating human endothelial cell exocytosis and permeability: the role of Rho-GTPases. Circulation Research. 92: 272-8. PMID 12595338 DOI: 10.1161/01.RES.0000057386.15390.A3 |
0.31 |
|
| 2003 |
Boven LA, Vergnolle N, Henry SD, Silva C, Imai Y, Holden J, Warren K, Hollenberg MD, Power C. Up-regulation of proteinase-activated receptor 1 expression in astrocytes during HIV encephalitis. Journal of Immunology (Baltimore, Md. : 1950). 170: 2638-46. PMID 12594292 DOI: 10.4049/Jimmunol.170.5.2638 |
0.36 |
|
| 2003 |
Dulon S, Candé C, Bunnett NW, Hollenberg MD, Chignard M, Pidard D. Proteinase-activated receptor-2 and human lung epithelial cells: disarming by neutrophil serine proteinases. American Journal of Respiratory Cell and Molecular Biology. 28: 339-46. PMID 12594060 DOI: 10.1165/Rcmb.4908 |
0.412 |
|
| 2003 |
Seymour ML, Zaidi NF, Hollenberg MD, MacNaughton WK. PAR1-dependent and independent increases in COX-2 and PGE2 in human colonic myofibroblasts stimulated by thrombin. American Journal of Physiology. Cell Physiology. 284: C1185-92. PMID 12505789 DOI: 10.1152/Ajpcell.00126.2002 |
0.307 |
|
| 2003 |
Compton SJ, McGuire JJ, Saifeddine M, Hollenberg MD. Restricted ability of human mast cell tryptase to activate proteinase-activated receptor-2 in rat aorta. Canadian Journal of Physiology and Pharmacology. 80: 987-92. PMID 12450065 DOI: 10.1139/Y02-125 |
0.396 |
|
| 2003 |
Compton SJ, Sandhu S, Wijesuriya SJ, Hollenberg MD. Glycosylation of human proteinase-activated receptor-2 (hPAR2): role in cell surface expression and signalling. The Biochemical Journal. 368: 495-505. PMID 12171601 DOI: 10.1042/Bj20020706 |
0.361 |
|
| 2003 |
Ferazzini MA, Santi S, Macnaughton WK, Hollenberg MD, Wallace JL, Vergnolle N. Proteinase-Activated Receptor-4 is implicated in the pathogenesis of Dextran Sodium Sulfate colitis Gastroenterology. 124: A487. DOI: 10.1016/S0016-5085(03)82463-0 |
0.441 |
|
| 2003 |
Armstrong C, Mokashi S, Wong J, Swaminathan S, Hollenberg M, Beck PL. Proteinase activated receptors (PAR-1,2) regulate intestinal wound repair in vitro Gastroenterology. 124: A300. DOI: 10.1016/S0016-5085(03)81510-X |
0.39 |
|
| 2003 |
Vergnolle N, Cellars L, Hollenberg MD, Wallace JL, Andrade-Gordon P. Proteinase-activated receptor-1 (PAR-1) is implicated in the pathogenesis of TNBS colitis Gastroenterology. 124: A83. DOI: 10.1016/S0016-5085(03)80410-9 |
0.447 |
|
| 2003 |
Buresi MC, Vergnolle N, Andrade-Gordon P, Hollenberg MD, Wallace JL, Macnaughton WK. Activation of protease-activated receptor-1 (PAR-1) inhibits neurally evoked chloride secretion in the mouse colon Gastroenterology. 124: A23. DOI: 10.1016/S0016-5085(03)80114-2 |
0.431 |
|
| 2003 |
Hollenberg MD, Wijesuriya SJ, Gui Y, Loutzenhiser R. Proteinase-activated receptors (PARs) and the kidney Drug Development Research. 60: 36-42. DOI: 10.1002/Ddr.10318 |
0.639 |
|
| 2003 |
Hollenberg MD, Compton SJ. Proteinase-activated receptor domains and signaling Drug Development Research. 59: 344-349. DOI: 10.1002/Ddr.10302 |
0.421 |
|
| 2003 |
Hollenberg MD. Proteinase-activated receptors: Tethered ligands and receptor-activating peptides Drug Development Research. 59: 336-343. DOI: 10.1002/Ddr.10301 |
0.434 |
|
| 2003 |
Hollenberg MD. Proteinase-activated receptors (PARs): An evolving hormonal system Drug Development Research. 59: 334-335. DOI: 10.1002/Ddr.10300 |
0.389 |
|
| 2002 |
McGuire JJ, Dai J, Andrade-Gordon P, Triggle CR, Hollenberg MD. Proteinase-activated receptor-2 (PAR2): vascular effects of a PAR2-derived activating peptide via a receptor different than PAR2. The Journal of Pharmacology and Experimental Therapeutics. 303: 985-92. PMID 12438518 DOI: 10.1124/Jpet.102.040352 |
0.403 |
|
| 2002 |
Pasha MK, Dimmock JR, Hollenberg MD, Sharma RK. Enhanced activity of human N-myristoyltransferase by dimethyl sulfoxide and related solvents in the presence of serine/threonine-containing peptide substrates. Biochemical Pharmacology. 64: 1461-7. PMID 12417259 DOI: 10.1016/S0006-2952(02)01412-0 |
0.334 |
|
| 2002 |
Cenac N, Coelho AM, Nguyen C, Compton S, Andrade-Gordon P, MacNaughton WK, Wallace JL, Hollenberg MD, Bunnett NW, Garcia-Villar R, Bueno L, Vergnolle N. Induction of intestinal inflammation in mouse by activation of proteinase-activated receptor-2. The American Journal of Pathology. 161: 1903-15. PMID 12414536 DOI: 10.1016/S0002-9440(10)64466-5 |
0.412 |
|
| 2002 |
Buresi MC, Buret AG, Hollenberg MD, MacNaughton WK. Activation of proteinase-activated receptor 1 stimulates epithelial chloride secretion through a unique MAP kinase- and cyclo-oxygenase-dependent pathway. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 16: 1515-25. PMID 12374774 DOI: 10.1096/Fj.02-0039Com |
0.458 |
|
| 2002 |
Hollenberg MD. PARs in the stars: proteinase-activated receptors and astrocyte function. Focus on "Thrombin (PAR-1)-induced proliferation in astrocytes via MAPK involves multiple signaling pathways". American Journal of Physiology. Cell Physiology. 283: C1347-50. PMID 12372795 DOI: 10.1152/Ajpcell.00304.2002 |
0.325 |
|
| 2002 |
Al-Ani B, Wijesuriya SJ, Hollenberg MD. Proteinase-activated receptor 2: differential activation of the receptor by tethered ligand and soluble peptide analogs. The Journal of Pharmacology and Experimental Therapeutics. 302: 1046-54. PMID 12183662 DOI: 10.1124/Jpet.302.3.1046 |
0.411 |
|
| 2002 |
Stenton GR, Nohara O, Déry RE, Vliagoftis H, Gilchrist M, Johri A, Wallace JL, Hollenberg MD, Moqbel R, Befus AD. Proteinase-activated receptor (PAR)-1 and -2 agonists induce mediator release from mast cells by pathways distinct from PAR-1 and PAR-2. The Journal of Pharmacology and Experimental Therapeutics. 302: 466-74. PMID 12130703 DOI: 10.1124/Jpet.302.2.466 |
0.398 |
|
| 2002 |
Nishikawa H, Kawai K, Nishimura S, Tanaka S, Araki H, Al-Ani B, Hollenberg MD, Kuroda R, Kawabata A. Suppression by protease-activated receptor-2 activation of gastric acid secretion in rats. European Journal of Pharmacology. 447: 87-90. PMID 12106807 DOI: 10.1016/S0014-2999(02)01892-7 |
0.375 |
|
| 2002 |
Hollenberg MD, Compton SJ. International Union of Pharmacology. XXVIII. Proteinase-activated receptors Pharmacological Reviews. 54: 203-217. PMID 12037136 DOI: 10.1124/Pr.54.2.203 |
0.454 |
|
| 2002 |
Trottier G, Hollenberg M, Wang X, Gui Y, Loutzenhiser K, Loutzenhiser R. PAR-2 elicits afferent arteriolar vasodilation by NO-dependent and NO-independent actions. American Journal of Physiology. Renal Physiology. 282: F891-7. PMID 11934700 DOI: 10.1152/Ajprenal.00233.2001 |
0.707 |
|
| 2002 |
Kawao N, Sakaguchi Y, Tagome A, Kuroda R, Nishida S, Irimajiri K, Nishikawa H, Kawai K, Hollenberg MD, Kawabata A. Protease-activated receptor-2 (PAR-2) in the rat gastric mucosa: immunolocalization and facilitation of pepsin/pepsinogen secretion. British Journal of Pharmacology. 135: 1292-6. PMID 11877338 DOI: 10.1038/Sj.Bjp.0704562 |
0.348 |
|
| 2002 |
Chung AW, Jurasz P, Hollenberg MD, Radomski MW. Mechanisms of action of proteinase-activated receptor agonists on human platelets. British Journal of Pharmacology. 135: 1123-32. PMID 11877318 DOI: 10.1038/Sj.Bjp.0704559 |
0.355 |
|
| 2002 |
Al-Ani B, Saifeddine M, Wijesuriya SJ, Hollenberg MD. Modified proteinase-activated receptor-1 and -2 derived peptides inhibit proteinase-activated receptor-2 activation by trypsin. The Journal of Pharmacology and Experimental Therapeutics. 300: 702-8. PMID 11805236 DOI: 10.1124/Jpet.300.2.702 |
0.457 |
|
| 2002 |
Tibbles LA, Spurrell JC, Bowen GP, Liu Q, Lam M, Zaiss AK, Robbins SM, Hollenberg MD, Wickham TJ, Muruve DA. Activation of p38 and ERK signaling during adenovirus vector cell entry lead to expression of the C-X-C chemokine IP-10. Journal of Virology. 76: 1559-68. PMID 11799150 DOI: 10.1128/Jvi.76.4.1559-1568.2002 |
0.35 |
|
| 2002 |
McGuire JJ, Hollenberg MD, Andrade-Gordon P, Triggle CR. Multiple mechanisms of vascular smooth muscle relaxation by the activation of proteinase-activated receptor 2 in mouse mesenteric arterioles. British Journal of Pharmacology. 135: 155-69. PMID 11786491 DOI: 10.1038/Sj.Bjp.0704469 |
0.341 |
|
| 2002 |
Taniguchi T, Azuma H, Okada Y, Naiki H, Hollenberg MD, Muramatsu I. Endothelin-1-endothelin receptor type A mediates closure of rat ductus arteriosus at birth. The Journal of Physiology. 537: 579-85. PMID 11731587 DOI: 10.1111/J.1469-7793.2001.00579.X |
0.315 |
|
| 2001 |
Fiorucci S, Mencarelli A, Palazzetti B, Distrutti E, Vergnolle N, Hollenberg MD, Wallace JL, Morelli A, Cirino G. Proteinase-activated receptor 2 is an anti-inflammatory signal for colonic lamina propria lymphocytes in a mouse model of colitis. Proceedings of the National Academy of Sciences of the United States of America. 98: 13936-41. PMID 11717450 DOI: 10.1073/Pnas.241377298 |
0.437 |
|
| 2001 |
Compton SJ, Renaux B, Wijesuriya SJ, Hollenberg MD. Glycosylation and the activation of proteinase-activated receptor 2 (PAR(2)) by human mast cell tryptase. British Journal of Pharmacology. 134: 705-18. PMID 11606310 DOI: 10.1038/Sj.Bjp.0704303 |
0.463 |
|
| 2001 |
Ma L, Hollenberg MD, Wallace JL. Thrombin-induced platelet endostatin release is blocked by a proteinase activated receptor-4 (PAR4) antagonist. British Journal of Pharmacology. 134: 701-4. PMID 11606309 DOI: 10.1038/Sj.Bjp.0704312 |
0.312 |
|
| 2001 |
de Garavilla L, Vergnolle N, Young SH, Ennes H, Steinhoff M, Ossovskaya VS, D'Andrea MR, Mayer EA, Wallace JL, Hollenberg MD, Andrade-Gordon P, Bunnett NW. Agonists of proteinase-activated receptor 1 induce plasma extravasation by a neurogenic mechanism. British Journal of Pharmacology. 133: 975-87. PMID 11487506 DOI: 10.1038/Sj.Bjp.0704152 |
0.396 |
|
| 2001 |
Buresi MC, Schleihauf E, Vergnolle N, Buret A, Wallace JL, Hollenberg MD, MacNaughton WK. Protease-activated receptor-1 stimulates Ca(2+)-dependent Cl(-) secretion in human intestinal epithelial cells. American Journal of Physiology. Gastrointestinal and Liver Physiology. 281: G323-32. PMID 11447011 DOI: 10.1152/Ajpgi.2001.281.2.G323 |
0.439 |
|
| 2001 |
Vergnolle N, Bunnett NW, Sharkey KA, Brussee V, Compton SJ, Grady EF, Cirino G, Gerard N, Basbaum AI, Andrade-Gordon P, Hollenberg MD, Wallace JL. Proteinase-activated receptor-2 and hyperalgesia: A novel pain pathway. Nature Medicine. 7: 821-6. PMID 11433347 DOI: 10.1038/89945 |
0.402 |
|
| 2001 |
Vliagoftis H, Befus AD, Hollenberg MD, Moqbel R. Airway epithelial cells release eosinophil survival-promoting factors (GM-CSF) after stimulation of proteinase-activated receptor 2. The Journal of Allergy and Clinical Immunology. 107: 679-85. PMID 11295658 DOI: 10.1067/Mai.2001.114245 |
0.429 |
|
| 2001 |
Zheng XL, Matsubara S, Diao C, Hollenberg MD, Wong NC. Epidermal growth factor induction of apolipoprotein A-I is mediated by the Ras-MAP kinase cascade and Sp1. The Journal of Biological Chemistry. 276: 13822-9. PMID 11278817 DOI: 10.1074/Jbc.M011031200 |
0.384 |
|
| 2001 |
Vergnolle N, Wallace JL, Bunnett NW, Hollenberg MD. Protease-activated receptors in inflammation, neuronal signaling and pain. Trends in Pharmacological Sciences. 22: 146-52. PMID 11239578 DOI: 10.1016/S0165-6147(00)01634-5 |
0.385 |
|
| 2001 |
Saifeddine M, Al-Ani B, Sandhu S, Wijesuriya SJ, Hollenberg MD. Contractile actions of proteinase-activated receptor-derived polypeptides in guinea-pig gastric and lung parenchymal strips: evidence for distinct receptor systems. British Journal of Pharmacology. 132: 556-66. PMID 11159706 DOI: 10.1038/Sj.Bjp.0703839 |
0.388 |
|
| 2001 |
Hollenberg MD. Receptor binding and agonist efficacy: new insights from mutants of the thrombin protease-activated receptor-1 (PAR-1). Molecular Pharmacology. 58: 1175-7. PMID 11093751 DOI: 10.1124/Mol.58.6.1175 |
0.422 |
|
| 2001 |
Compton SJ, Cairns JA, Palmer KJ, Al-Ani B, Hollenberg MD, Walls AF. A polymorphic protease-activated receptor 2 (PAR2) displaying reduced sensitivity to trypsin and differential responses to PAR agonists. The Journal of Biological Chemistry. 275: 39207-12. PMID 10995771 DOI: 10.1074/JBC.M007215200 |
0.301 |
|
| 2001 |
Hollenberg MD, Saifeddine M. Proteinase-activated receptor 4 (PAR4): activation and inhibition of rat platelet aggregation by PAR4-derived peptides Canadian Journal of Physiology and Pharmacology. 79: 439-442. DOI: 10.1139/Y01-013 |
0.4 |
|
| 2001 |
Coelho A, Guiard B, Garcia-Villar R, Vergnolle N, Hollenberg MD, Wallace JL, Fioramonti J, Bueno L. Proteinase-activated recaptor-2 (PAR-2) activation produces delayed rectal hyperalgesia in awake rats Gastroenterology. 120: A178. DOI: 10.1016/S0016-5085(08)80880-3 |
0.323 |
|
| 2000 |
Vliagoftis H, Schwingshackl A, Milne CD, Duszyk M, Hollenberg MD, Wallace JL, Befus AD, Moqbel R. Proteinase-activated receptor-2-mediated matrix metalloproteinase-9 release from airway epithelial cells. The Journal of Allergy and Clinical Immunology. 106: 537-45. PMID 10984375 DOI: 10.1067/Mai.2000.109058 |
0.357 |
|
| 2000 |
Gui Y, Zheng XL, Hollenberg MD. Interleukin-1beta, Src- and non-Src tyrosine kinases, and nitric oxide synthase induction in rat aorta in vitro. American Journal of Physiology. Heart and Circulatory Physiology. 279: H566-76. PMID 10924055 DOI: 10.1152/Ajpheart.2000.279.2.H566 |
0.617 |
|
| 2000 |
Zheng XL, Matsubara S, Diao C, Hollenberg MD, Wong NC. Activation of apolipoprotein AI gene expression by protein kinase A and kinase C through transcription factor, Sp1. The Journal of Biological Chemistry. 275: 31747-54. PMID 10829013 DOI: 10.1074/Jbc.M000621200 |
0.372 |
|
| 2000 |
Kawabata A, Nishikawa H, Kuroda R, Kawai K, Hollenberg MD. Proteinase-activated receptor-2 (PAR-2): regulation of salivary and pancreatic exocrine secretion in vivo in rats and mice. British Journal of Pharmacology. 129: 1808-14. PMID 10780990 DOI: 10.1038/Sj.Bjp.0703274 |
0.393 |
|
| 2000 |
Hollenberg MD, Saifeddine M, Zwiers H. Proteinase-activated receptors (PARs): activation of PAR1 and PAR2 by a proteolytic fragment of the neuronal growth associated protein B-50/GAP-43. Canadian Journal of Physiology and Pharmacology. 78: 81-5. PMID 10741764 DOI: 10.1139/Cjpp-78-1-81 |
0.384 |
|
| 2000 |
Steinhoff M, Vergnolle N, Young SH, Tognetto M, Amadesi S, Ennes HS, Trevisani M, Hollenberg MD, Wallace JL, Caughey GH, Mitchell SE, Williams LM, Geppetti P, Mayer EA, Bunnett NW. Agonists of proteinase-activated receptor 2 induce inflammation by a neurogenic mechanism. Nature Medicine. 6: 151-8. PMID 10655102 DOI: 10.1038/72247 |
0.467 |
|
| 2000 |
Akers IA, Parsons M, Hill MR, Hollenberg MD, Sanjar S, Laurent GJ, McAnulty RJ. Mast cell tryptase stimulates human lung fibroblast proliferation via protease-activated receptor-2. American Journal of Physiology. Lung Cellular and Molecular Physiology. 278: L193-201. PMID 10645907 DOI: 10.1152/Ajplung.2000.278.1.L193 |
0.398 |
|
| 2000 |
Kawabata A, Kuroda R, Hollenberg MD. [Physiology of protease-activated receptors (PARs): involvement of PARs in digestive functions]. Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica. 173P-179P. PMID 10629876 DOI: 10.1254/Fpj.114.Supplement_173 |
0.477 |
|
| 2000 |
Al-Ani B, Saifeddine M, Kawabata A, Hollenberg MD. Proteinase activated receptor 2: Role of extracellular loop 2 for ligand-mediated activation. British Journal of Pharmacology. 128: 1105-13. PMID 10556949 DOI: 10.1038/Sj.Bjp.0702834 |
0.447 |
|
| 1999 |
Fernandez-Patron C, Zhang Y, Radomski MW, Hollenberg MD, Sandra T D. Rapid release of matrix metalloproteinase (MMP)-2 by thrombin in the rat aorta: Modulation by protein tyrosine kinase/phosphatase Thrombosis and Haemostasis. 82: 1353-1357. PMID 10544927 DOI: 10.1055/S-0037-1614389 |
0.33 |
|
| 1999 |
Hollenberg MD, Saifeddine M, Al-Ani B, Gui Y. Proteinase-activated receptor 4 (PAR4): action of PAR4-activating peptides in vascular and gastric tissue and lack of cross-reactivity with PAR1 and PAR2. Canadian Journal of Physiology and Pharmacology. 77: 458-64. PMID 10537233 DOI: 10.1139/Y99-090 |
0.693 |
|
| 1999 |
Vergnolle N, Hollenberg MD, Sharkey KA, Wallace JL. Characterization of the inflammatory response to proteinase-activated receptor-2 (PAR2)-activating peptides in the rat paw. British Journal of Pharmacology. 127: 1083-90. PMID 10455252 DOI: 10.1038/Sj.Bjp.0702634 |
0.387 |
|
| 1999 |
Alexopoulos K, Fatseas P, Melissari E, Vlahakos D, Smith J, Mavromoustakos T, Saifeddine M, Moore G, Hollenberg M, Matsoukas J. Design and synthesis of thrombin receptor-derived nonpeptide mimetics utilizing a piperazine scaffold. Bioorganic & Medicinal Chemistry. 7: 1033-41. PMID 10428371 DOI: 10.1016/S0968-0896(99)00017-6 |
0.437 |
|
| 1999 |
Hollenberg MD. Protease-activated receptors: PAR4 and counting: how long is the course? Trends in Pharmacological Sciences. 20: 271-3. PMID 10390644 DOI: 10.1016/S0165-6147(99)01333-4 |
0.406 |
|
| 1999 |
Corvera CU, Déry O, McConalogue K, Gamp P, Thoma M, Al-Ani B, Caughey GH, Hollenberg MD, Bunnett NW. Thrombin and mast cell tryptase regulate guinea-pig myenteric neurons through proteinase-activated receptors-1 and -2. The Journal of Physiology. 741-56. PMID 10358115 DOI: 10.1111/J.1469-7793.1999.0741S.X |
0.353 |
|
| 1999 |
Zheng XL, Gui Y, Sharkey KA, Hollenberg MD. Differential induction of nitric oxide synthase in rat gastric and vascular smooth muscle tissue: distinct tissue distribution and distinctive signaling pathways. The Journal of Pharmacology and Experimental Therapeutics. 289: 632-40. PMID 10215633 |
0.589 |
|
| 1999 |
Vergnolle N, Hollenberg MD, Wallace JL. Pro- and anti-inflammatory actions of thrombin: a distinct role for proteinase-activated receptor-1 (PAR1). British Journal of Pharmacology. 126: 1262-8. PMID 10205017 DOI: 10.1038/Sj.Bjp.0702408 |
0.443 |
|
| 1999 |
Saifeddine M, Roy SS, Al-Ani B, Triggle CR, Hollenberg MD. Endothelium-dependent contractile actions of proteinase-activated receptor-2-activating peptides in human umbilical vein: release of a contracting factor via a novel receptor. British Journal of Pharmacology. 125: 1445-54. PMID 9884072 DOI: 10.1038/Sj.Bjp.0702213 |
0.414 |
|
| 1999 |
Oda Y, Renaux B, Bjorge J, Saifeddine M, Fujita DJ, Hollenberg MD. cSrc is a major cytosolic tyrosine kinase in vascular tissue Canadian Journal of Physiology and Pharmacology. 77: 606-617. DOI: 10.1139/Y99-052 |
0.333 |
|
| 1999 |
Robbins SM, Hollenberg MD. Chapter 11 Plasma Membrane-Localized Signal Transduction Current Topics in Membranes and Transport. 48: 351-395. DOI: 10.1016/S0070-2161(08)61049-7 |
0.37 |
|
| 1998 |
Vergnolle N, Macnaughton WK, Al-Ani B, Saifeddine M, Wallace JL, Hollenberg MD. Proteinase-activated receptor 2 (PAR2)-activating peptides: identification of a receptor distinct from PAR2 that regulates intestinal transport. Proceedings of the National Academy of Sciences of the United States of America. 95: 7766-71. PMID 9636225 DOI: 10.1073/Pnas.95.13.7766 |
0.428 |
|
| 1998 |
Roy SS, Saifeddine M, Loutzenhiser R, Triggle CR, Hollenberg MD. Dual endothelium-dependent vascular activities of proteinase-activated receptor-2-activating peptides: evidence for receptor heterogeneity. British Journal of Pharmacology. 123: 1434-40. PMID 9579740 DOI: 10.1038/Sj.Bjp.0701726 |
0.408 |
|
| 1998 |
Vergnolle N, MacNaughton W, Wallace J, Hollenberg M. Stimulation of intestinal chloride secretion by a protease-activated receptor-2 activating peptide Gastroenterology. 114: A429. DOI: 10.1016/S0016-5085(98)81739-3 |
0.42 |
|
| 1997 |
Zheng XL, Sharkey KA, Hollenberg MD. Induction of nitric oxide synthase in rat gastric smooth muscle preparations. The American Journal of Physiology. 273: G1101-7. PMID 9374708 DOI: 10.1152/Ajpgi.1997.273.5.G1101 |
0.312 |
|
| 1997 |
Kong W, McConalogue K, Khitin LM, Hollenberg MD, Payan DG, Böhm SK, Bunnett NW. Luminal trypsin may regulate enterocytes through proteinase-activated receptor 2. Proceedings of the National Academy of Sciences of the United States of America. 94: 8884-9. PMID 9238072 DOI: 10.1073/Pnas.94.16.8884 |
0.437 |
|
| 1997 |
Matsoukas J, Hollenberg MD, Mavromoustakos T, Panagiotopoulos D, Alexopoulos K, Yamdagni R, Wu Q, Moore GJ. Conformational analysis of the thrombin receptor agonist peptides SFLLR and SFLLR-NH2 by NMR: evidence for a cyclic bioactive conformation. Journal of Protein Chemistry. 16: 113-31. PMID 9112605 DOI: 10.1023/A:1026342001226 |
0.338 |
|
| 1997 |
Laniyonu A, Eto S, Wang JH, Hollenberg MD. Detection of sarcoma virus family tyrosine kinase activity in coronary arterial tissue. Canadian Journal of Physiology and Pharmacology. 73: 1552-60. PMID 8789407 DOI: 10.1139/Y95-214 |
0.321 |
|
| 1997 |
Saifeddine M, al-Ani B, Cheng CH, Wang L, Hollenberg MD. Rat proteinase-activated receptor-2 (PAR-2): cDNA sequence and activity of receptor-derived peptides in gastric and vascular tissue. British Journal of Pharmacology. 118: 521-30. PMID 8762073 DOI: 10.1111/J.1476-5381.1996.Tb15433.X |
0.446 |
|
| 1997 |
Severson DL, Hollenberg MD. Chapter 17 The plasma membrane as a transducer and amplifier Principles of Medical Biology. 7: 387-419. DOI: 10.1016/S1569-2582(97)80125-0 |
0.383 |
|
| 1996 |
Hollenberg MD, Mokashi S, Leblond L, DiMaio J. Synergistic actions of a thrombin-derived synthetic peptide and a thrombin receptor-activating peptide in simulating fibroblast mitogenesis Journal of Cellular Physiology. 169: 491-496. PMID 8952698 DOI: 10.1002/(Sici)1097-4652(199612)169:3<491::Aid-Jcp9>3.0.Co;2-J |
0.403 |
|
| 1996 |
Matsoukas JM, Panagiotopoulos D, Keramida M, Mavromoustakos T, Yamdagni R, Wu Q, Moore GJ, Saifeddine M, Hollenberg MD. Synthesis and contractile activities of cyclic thrombin receptor-derived peptide analogues with a Phe-Leu-Leu-Arg motif: importance of the Phe/Arg relative conformation and the primary amino group for activity. Journal of Medicinal Chemistry. 39: 3585-91. PMID 8784457 DOI: 10.1021/Jm950690V |
0.346 |
|
| 1996 |
Shivji F, Cheng H, Zwiers H, Hollenberg MD, Hanley DA. Identification of classical, novel, and atypical protein kinase C isoenzymes in the bovine parathyroid. Endocrinology. 137: 3777-83. PMID 8756546 DOI: 10.1210/Endo.137.9.8756546 |
0.303 |
|
| 1996 |
Hollenberg MD. Tyrosine kinase-mediated signal transduction pathways and the actions of polypeptide growth factors and G-protein-coupled agonists in smooth muscle. Molecular and Cellular Biochemistry. 77-85. PMID 8569752 DOI: 10.1007/Bf01076566 |
0.367 |
|
| 1996 |
al-Ani B, Saifeddine M, Hollenberg MD. Detection of functional receptors for the proteinase-activated-receptor-2-activating polypeptide, SLIGRL-NH2, in rat vascular and gastric smooth muscle. Canadian Journal of Physiology and Pharmacology. 73: 1203-7. PMID 8564891 DOI: 10.1139/Y95-172 |
0.433 |
|
| 1996 |
Panagiotopoulos D, Matsoukas JM, Alexopoulos K, Zebeki A, Mavromoustakos T, Saifeddine M, Hollenberg MD. Synthesis and activities of cyclic thrombin-receptor-derived peptide analogues of the Ser42-Phe-Leu-Leu-Arg46 motif sequence containing d-Phe and/or d-Arg Letters in Peptide Science. 3: 233-240. DOI: 10.1007/Bf00128113 |
0.362 |
|
| 1995 |
Laniyonu AA, Saifeddine M, Yang SG, Hollenberg MD. Tyrosine kinase inhibitors and the contractile action of G-protein-linked vascular agonists. Canadian Journal of Physiology and Pharmacology. 72: 1075-85. PMID 7842390 DOI: 10.1139/Y94-150 |
0.322 |
|
| 1995 |
Tay-Uyboco J, Poon MC, Ahmad S, Hollenberg MD. Contractile actions of thrombin receptor-derived polypeptides in human umbilical and placental vasculature: evidence for distinct receptor systems. British Journal of Pharmacology. 115: 569-78. PMID 7582474 DOI: 10.1111/J.1476-5381.1995.Tb14970.X |
0.357 |
|
| 1995 |
Laniyonu A, Saifeddine M, Ahmad S, Hollenberg MD. Regulation of vascular and gastric smooth muscle contractility by pervanadate. British Journal of Pharmacology. 113: 403-10. PMID 7530569 DOI: 10.1111/J.1476-5381.1994.Tb17003.X |
0.346 |
|
| 1994 |
Hollenberg MD. The acute actions of growth factors in smooth muscle systems. Life Sciences. 54: 223-35. PMID 8289582 DOI: 10.1016/0024-3205(94)00811-6 |
0.319 |
|
| 1994 |
Hollenberg MD. Tyrosine kinase pathways and the regulation of smooth muscle contractility. Trends in Pharmacological Sciences. 15: 108-14. PMID 8016894 DOI: 10.1016/0165-6147(94)90046-9 |
0.373 |
|
| 1994 |
Shimomura A, Itoh H, Niki Y, Suga T, Fujioka H, Ito M, Konishi T, Hollenberg MD, Nakano T. Contractile actions of endothelins in rat gastric body: evidence for receptor subtypes and involvement of prostaglandin E2. European Journal of Pharmacology. 252: 81-6. PMID 7908644 DOI: 10.1016/0014-2999(94)90578-9 |
0.321 |
|
| 1992 |
Mokashi S, Severson DL, Hollenberg MD. Synergistic actions of epidermal growth factor-urogastrone and vasopressin in cultured aortic A-10 smooth muscle cells. Journal of Cellular Physiology. 152: 372-81. PMID 1386368 DOI: 10.1002/Jcp.1041520219 |
0.367 |
|
| 1992 |
Muramatsu I, Laniyonu A, Moore GJ, Hollenberg MD. Vascular actions of thrombin receptor peptide. Canadian Journal of Physiology and Pharmacology. 70: 996-1003. PMID 1333353 DOI: 10.1139/Y92-137 |
0.332 |
|
| 1992 |
Yang SG, Laniyonu A, Saifeddine M, Moore GJ, Hollenberg MD. Actions of thrombin and thrombin receptor peptide analogues in gastric and aortic smooth muscle: development of bioassays for structure-activity studies. Life Sciences. 51: 1325-32. PMID 1328791 DOI: 10.1016/0024-3205(92)90631-X |
0.408 |
|
| 1992 |
Yang SG, Saifeddine M, Hollenberg MD. Tyrosine kinase inhibitors and the contractile action of epidermal growth factor-urogastrone and other agonists in gastric smooth muscle. Canadian Journal of Physiology and Pharmacology. 70: 85-93. PMID 1316219 DOI: 10.1139/Y92-012 |
0.323 |
|
| 1991 |
Yang SG, Hollenberg MD. Distinct receptors for epidermal growth factor-urogastrone in cultured gastric smooth muscle cells. The American Journal of Physiology. 260: G827-34. PMID 2058672 DOI: 10.1152/Ajpgi.1991.260.6.G827 |
0.312 |
|
| 1991 |
Zhao DY, Hollenberg MD, Severson DL. Calmodulin inhibits the protein kinase C-catalysed phosphorylation of an endogenous protein in A10 smooth-muscle cells. The Biochemical Journal. 445-50. PMID 1859372 DOI: 10.1042/Bj2770445 |
0.303 |
|
| 1991 |
Hollenberg MD. Structure-activity relationships for transmembrane signaling: the receptor's turn. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 5: 178-86. PMID 1848518 DOI: 10.1096/Fasebj.5.2.1848518 |
0.423 |
|
| 1991 |
Wallukat G, Boehmer FD, Engstroem U, Langen P, Hollenberg M, Behlke J, Kuehn H, Grosse R. Modulation of the beta-adrenergic-response in cultured rat heart cells. II. Mammary-derived growth inhibitor (MDGI) blocks induction of beta-adrenergic supersensitivity. Dissociation from lipid-binding activity of MDGI. Molecular and Cellular Biochemistry. 102: 49-60. PMID 1646956 DOI: 10.1007/Bf00232157 |
0.354 |
|
| 1990 |
Hollenberg MD. Receptor triggering and receptor regulation: structure-activity relationships from the receptor's point of view. Journal of Medicinal Chemistry. 33: 1275-81. PMID 2158558 DOI: 10.1021/Jm00167A001 |
0.398 |
|
| 1990 |
Song-Gui Yang, Winkler ME, Hollenberg MD. Contribution of the C-terminal dipeptide of transforming growth factor-α to its activity: biochemical and pharmacologic profiles European Journal of Pharmacology: Molecular Pharmacology. 188: 289-300. PMID 2115447 DOI: 10.1016/0922-4106(90)90189-5 |
0.328 |
|
| 1989 |
Itoh H, Muramatsu I, Patel P, Lederis K, Hollenberg MD. Inhibition by anti-inflammatory agents of contraction induced by epidermal growth factor-urogastrone in isolated longitudinal smooth muscle strips from guinea-pig stomach. British Journal of Pharmacology. 95: 821-9. PMID 3264733 DOI: 10.1111/J.1476-5381.1988.Tb11710.X |
0.339 |
|
| 1989 |
Patel P, Itoh H, Lederis K, Hollenberg MD. Contraction of guinea pig trachea by epidermal growth factor--urogastrone. Canadian Journal of Physiology and Pharmacology. 66: 1308-12. PMID 3149204 DOI: 10.1139/Y88-214 |
0.336 |
|
| 1989 |
Gan BS, Hollenberg MD. Autoradiographic localization of binding sites for epidermal growth factor-urogastrone (EGF-URO) in coronary arteries European Journal of Pharmacology. 167: 407-410. PMID 2806378 DOI: 10.1016/0014-2999(89)90449-4 |
0.333 |
|
| 1989 |
Blay J, Hollenberg MD. Heterologous regulation of EGF receptor function in cultured aortic smooth muscle cells. European Journal of Pharmacology. 172: 1-7. PMID 2714368 DOI: 10.1016/0922-4106(89)90039-4 |
0.356 |
|
| 1989 |
Blay J, Valentine-Braun KA, Northup JK, Hollenberg MD. Epidermal-growth-factor-stimulated phosphorylation of calpactin II in membrane vesicles shed from cultured A-431 cells. The Biochemical Journal. 259: 577-83. PMID 2524190 DOI: 10.1042/Bj2590577 |
0.371 |
|
| 1988 |
Northup JK, Valentine-Braun KA, Johnson LK, Severson DL, Hollenberg MD. Evaluation of the antiinflammatory and phospholipase-inhibitory activity of calpactin II/lipocortin I. The Journal of Clinical Investigation. 82: 1347-52. PMID 2971676 DOI: 10.1172/Jci113737 |
0.376 |
|
| 1988 |
Valentine-Braun KA, Hollenberg MD, Fraser E, Northup JK. Isolation of a major human placental substrate for the epidermal growth factor (urogastrone) receptor kinase: immunological cross-reactivity with transducin and sequence homology with lipocortin. Archives of Biochemistry and Biophysics. 259: 262-82. PMID 2962537 DOI: 10.1016/0003-9861(87)90494-2 |
0.323 |
|
| 1987 |
Soley M, Hollenberg MD. Epidermal growth factor (urogastrone)-stimulated gluconeogenesis in isolated mouse hepatocytes. Archives of Biochemistry and Biophysics. 255: 136-46. PMID 3496044 DOI: 10.1016/0003-9861(87)90303-1 |
0.368 |
|
| 1987 |
Muramatsu I, Hollenberg MD, Lederis K. Modulation by epidermal growth factor--urogastrone of contraction in isolated canine helical mesenteric arterial strips. Canadian Journal of Physiology and Pharmacology. 64: 1561-5. PMID 3493833 DOI: 10.1139/Y86-262 |
0.333 |
|
| 1987 |
Hollenberg MD. SARs: the receptor side of the coin Trends in Pharmacological Sciences. 8: 197-199. DOI: 10.1016/0165-6147(87)90055-1 |
0.374 |
|
| 1986 |
Muramatsu I, Hollenberg MD, Lederis K. Vascular actions of epidermal growth factor-urogastrone: possible relationship to prostaglandin production. Canadian Journal of Physiology and Pharmacology. 63: 994-9. PMID 3878226 DOI: 10.1139/Y85-164 |
0.333 |
|
| 1986 |
Valentine-Braun KA, Northup JK, Hollenberg MD. Epidermal growth factor (urogastrone)-mediated phosphorylation of a 35-kDa substrate in human placental membranes: relationship to the beta subunit of the guanine nucleotide regulatory complex. Proceedings of the National Academy of Sciences of the United States of America. 83: 236-40. PMID 3079907 DOI: 10.1073/Pnas.83.2.236 |
0.321 |
|
| 1986 |
Aglio LS, Maturo JM, Hollenberg MD. Receptors for insulin and epidermal growth factor: interaction with organomercurial agarose. Journal of Cellular Biochemistry. 28: 143-57. PMID 3001106 DOI: 10.1002/Jcb.240280207 |
0.385 |
|
| 1986 |
Pallen CJ, Valentine KA, Wang JH, Hollenberg MD. Calcineurin-mediated dephosphorylation of the human placental membrane receptor for epidermal growth factor urogastrone. Biochemistry. 24: 4727-30. PMID 2416335 DOI: 10.1021/Bi00339A003 |
0.385 |
|
| 1985 |
Hollenberg M. Pathophysiological and therapeutic implications of receptor regulation Trends in Pharmacological Sciences. 6: 334-337. DOI: 10.1016/0165-6147(85)90154-3 |
0.381 |
|
| 1985 |
Hollenberg M. Biochemical mechanisms of receptor regulation Trends in Pharmacological Sciences. 6: 299-302. DOI: 10.1016/0165-6147(85)90137-3 |
0.39 |
|
| 1985 |
Hollenberg M. Examples of homospecific and heterospecific receptor regulation Trends in Pharmacological Sciences. 6: 242-245. DOI: 10.1016/0165-6147(85)90115-4 |
0.405 |
|
| 1984 |
Hanif K, Goren HJ, Geonzon RM, Lederis K, Hollenberg MD. Oxytocin resistance in Brattleboro rat adipocytes and comparative studies on insulin or oxytocin responsiveness in normal rat adipocytes. Canadian Journal of Physiology and Pharmacology. 61: 1418-25. PMID 6362806 DOI: 10.1139/Y83-202 |
0.305 |
|
| 1983 |
Bhaumick B, Armstrong GD, Hollenberg MD, Bala RM. Characterization of the human placental receptor for basic somatomedin. Canadian Journal of Biochemistry. 60: 923-31. PMID 6756616 DOI: 10.1139/O82-119 |
0.36 |
|
| 1983 |
Lin SL, Ts'o PO, Hollenberg MD. Epidermal growth factor-urogastrone action: induction of 2',5'-oligoadenylate synthetase activity and enhancement of the mitogenic effect by anti-interferon antibody. Life Sciences. 32: 1479-88. PMID 6601224 DOI: 10.1016/0024-3205(83)90914-1 |
0.327 |
|
| 1983 |
Armstrong GD, Hollenberg MD, Bhaumick B, Bala RM. Comparative studies on human placental insulin and basic somatomedin receptors. Journal of Cellular Biochemistry. 20: 283-92. PMID 6302119 DOI: 10.1002/Jcb.240200308 |
0.338 |
|
| 1983 |
Hollenberg M, Goren H, Hanif K, Lederis K. Oxytocin, its receptor and its insulin-like activity: A new look at an old hormone Trends in Pharmacological Sciences. 4: 310-312. DOI: 10.1016/0165-6147(83)90415-7 |
0.365 |
|
| 1982 |
Hanif K, Goren HJ, Hollenberg MD, Lederis K. Oxytocin action: lipid metabolism in adipocytes from homozygous diabetes insipidus rats (Brattleboro strain). Canadian Journal of Physiology and Pharmacology. 60: 993-7. PMID 6290016 DOI: 10.1139/Y82-140 |
0.313 |
|
| 1982 |
Hollenberg MD. Receptor mediated phosphorylation reactions Trends in Pharmacological Sciences. 3: 271-273. DOI: 10.1016/0165-6147(82)91131-2 |
0.344 |
|
| 1982 |
Hollenberg MD. Membrane receptors and hormone action II New perspectives for receptor-modulated cell function Trends in Pharmacological Sciences. 3: 25-28. DOI: 10.1016/0165-6147(82)90993-2 |
0.37 |
|
| 1981 |
Bhaumick B, Bala RM, Hollenberg MD. Somatomedin receptor of human placenta: solubilization, photolabeling, partial purification, and comparison with insulin receptor. Proceedings of the National Academy of Sciences of the United States of America. 78: 4279-83. PMID 6270667 DOI: 10.1073/Pnas.78.7.4279 |
0.39 |
|
| 1981 |
Goren HJ, Geonzon RM, Hollenberg MD, Lederis K, Morgan DO. Oxytocin action: lack of correlation between receptor number and tissue responsiveness. Journal of Supramolecular Structure. 14: 129-38. PMID 6262573 DOI: 10.1002/Jss.400140202 |
0.341 |
|
| 1981 |
Lin SL, Ts'o PO, Hollenberg MD. The effects of interferon on epidermal growth factor action. Biochemical and Biophysical Research Communications. 96: 168-74. PMID 6159884 DOI: 10.1016/0006-291X(80)91196-1 |
0.344 |
|
| 1981 |
Hollenberg MD. Membrane receptors and hormone action I new trends related to receptor structure and receptor regulation Trends in Pharmacological Sciences. 2: 320-323. DOI: 10.1016/0165-6147(81)90353-9 |
0.377 |
|
| 1980 |
Berhanu P, Hollenberg MD. Epidermal growth factor-urogastrone receptor: selective alteration in simian virus 40 transformed mouse fibroblasts. Archives of Biochemistry and Biophysics. 203: 134-44. PMID 6250481 DOI: 10.1016/0003-9861(80)90161-7 |
0.353 |
|
| 1980 |
Nexø E, Hollenberg MD, Figueroa A, Pratt RM. Detection of epidermal growth factor-urogastrone and its receptor during fetal mouse development. Proceedings of the National Academy of Sciences of the United States of America. 77: 2782-5. PMID 6248866 DOI: 10.1073/Pnas.77.5.2782 |
0.319 |
|
| 1980 |
Hollenberg MD. Epidermal growth factor-urogastrone, a polypeptide acquiring hormonal status. Vitamins and Hormones. 37: 69-110. PMID 398091 DOI: 10.1016/S0083-6729(08)61068-7 |
0.327 |
|
| 1979 |
Maturo JM, Shackelford WH, Hollenberg MD. Characteristics of the solubilized insulin receptor of human placenta. Life Sciences. 23: 2063-71. PMID 723465 DOI: 10.1016/0024-3205(78)90240-0 |
0.351 |
|
| 1979 |
Hock RA, Nexø E, Hollenberg MD. Isolation of the human placenta receptor for epidermal growth factor-urogastrone. Nature. 277: 403-5. PMID 233121 DOI: 10.1038/277403A0 |
0.413 |
|
| 1979 |
Hollenberg MD, Schneider EL. Receptors for insulin and epidermal growth factor-urogastrone in adult human fibroblasts do not change with donor age. Mechanisms of Ageing and Development. 11: 37-43. PMID 226815 DOI: 10.1016/0047-6374(79)90062-9 |
0.322 |
|
| 1979 |
Beckman BS, Hollenberg MD. Beta-adrenergic receptors and adenylate cyclase activity in rat reticulocytes and mature erythrocytes. Biochemical Pharmacology. 28: 239-48. PMID 218589 DOI: 10.1016/0006-2952(79)90510-0 |
0.379 |
|
| 1978 |
Hollenberg MD, Fryklund L. Insulin and somatomedins A and B: comparisons of biological activities in cultured human skin-derived fibroblasts. Life Sciences. 21: 943-50. PMID 562961 DOI: 10.1016/0024-3205(77)90260-0 |
0.31 |
|
| 1978 |
Maturo JM, Hollenberg MD. Insulin receptor: interaction with nonreceptor glycoprotein from liver cell membranes. Proceedings of the National Academy of Sciences of the United States of America. 75: 3070-4. PMID 277909 DOI: 10.1073/Pnas.75.7.3070 |
0.346 |
|
| 1978 |
Sahyoun N, Hock RA, Hollenberg MD. Insulin and epidermal growth factor-urogastrone: affinity crosslinking to specific binding sites in rat liver membranes. Proceedings of the National Academy of Sciences of the United States of America. 75: 1675-9. PMID 205865 DOI: 10.1073/Pnas.75.4.1675 |
0.306 |
|
| 1978 |
Hollenberg MD, Cuatrecasas P. Membrane receptors and hormone action: Recent developments Progress in Neuro-Psychopharmacology. 2: 287-302. DOI: 10.1016/0364-7722(78)90087-5 |
0.413 |
|
| 1977 |
Sahyoun N, Hollenberg MD, Bennett V, Cuatrecasas P. Topographic separation of adenylate cyclase and hormone receptors in the plasma membrane of toad erythrocyte ghosts. Proceedings of the National Academy of Sciences of the United States of America. 74: 2860-4. PMID 197522 DOI: 10.1073/Pnas.74.7.2860 |
0.357 |
|
| 1977 |
Bylund DB, Tellez-Iñon MT, Hollenberg MD. Age-related parallel decline in beta-adrenergic receptors, adenylate cyclase and phosphodiesterase activity in rat erythrocyte membranes. Life Sciences. 21: 403-10. PMID 197363 DOI: 10.1016/0024-3205(77)90521-5 |
0.357 |
|
| 1977 |
Hollenberg MD, Gregory H. Human urogastrone and mouse epidermal growth factor share a common receptor site in cultured human fibroblasts. Life Sciences. 20: 267-74. PMID 190507 DOI: 10.1016/0024-3205(77)90321-6 |
0.348 |
|
| 1976 |
Charness ME, Bylund DB, Beckman BS, Hollenberg MD, Snyder SH. Independent variation of beta-adrenergic receptor binding and catecholamine-stimulated adenylate cyclase activity in rat erythrocytes. Life Sciences. 19: 243-9. PMID 957867 DOI: 10.1016/0024-3205(76)90396-9 |
0.402 |
|
| 1976 |
Cuatrecasas P, Hollenberg MD. Membrane receptors and hormone action. Advances in Protein Chemistry. 30: 251-451. PMID 180780 DOI: 10.1016/S0065-3233(08)60481-7 |
0.391 |
|
| 1976 |
Hollenberg MD. Action of insulin analogues on cultured human fibroblasts reflects biological potency. Life Sciences. 18: 521-7. PMID 176556 DOI: 10.1016/0024-3205(76)90330-1 |
0.306 |
|
| 1976 |
Bennett V, Craig S, Hollenberg MD, O'Keefe E, Sahyoun N, Cuatrecasas P. Structure and function of cholera toxin and hormone receptors. Journal of Supramolecular Structure. 4: 99-120. PMID 176537 DOI: 10.1002/Jss.400040110 |
0.386 |
|
| 1976 |
Hollenberg MD. Receptors for insulin and epidermal growth factor: relation to synthesis of DNA in cultured rabbit lens epithelium. Archives of Biochemistry and Biophysics. 171: 371-7. PMID 173241 DOI: 10.1016/0003-9861(75)90045-4 |
0.312 |
|
| 1975 |
Cuatrecasas P, Hollenberg MD, Chang KJ, Bennett V. Hormone receptor complexes and their modulation of membrane function. Recent Progress in Hormone Research. 31: 37-94. PMID 172994 DOI: 10.1016/B978-0-12-571131-9.50006-2 |
0.367 |
|
| 1975 |
Cuatrecasas P, Hollenberg MD. Binding of insulin and other hormones to non-receptor materials: saturability, specificity and apparent "negative cooperativity". Biochemical and Biophysical Research Communications. 62: 31-41. PMID 163080 DOI: 10.1016/S0006-291X(75)80401-3 |
0.337 |
|
| 1974 |
O'Keefe E, Hollenberg MD, Cuatrecasas P. Epidermal growth factor. Characteristics of specific binding in membranes from liver, placenta, and other target tissues. Archives of Biochemistry and Biophysics. 164: 518-26. PMID 4376663 DOI: 10.1016/0003-9861(74)90062-9 |
0.315 |
|
| 1973 |
Hollenberg MD, Cuatrecasas P. Epidermal growth factor: receptors in human fibroblasts and modulation of action by cholera toxin. Proceedings of the National Academy of Sciences of the United States of America. 70: 2964-8. PMID 4355377 DOI: 10.1073/Pnas.70.10.2964 |
0.357 |
|
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