Stephen B. Liggett - Publications

Affiliations: 
University of Cincinnati, Cincinnati, OH 
Area:
Pharmacology, Molecular Biology

58 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 An SS, Mitzner W, Tang WY, Ahn K, Yoon AR, Huang J, Kilic O, Yong HM, Fahey JW, Kumar S, Biswal S, Holgate ST, Panettieri RA, Solway J, Liggett SB. An inflammation-independent contraction mechanophenotype of airway smooth muscle in asthma. The Journal of Allergy and Clinical Immunology. PMID 26936804 DOI: 10.1016/j.jaci.2015.12.1315  0.4
2015 Camoretti-Mercado B, Pauer SH, Yong HM, Smith DC, Deshpande DA, An SS, Liggett SB. Pleiotropic Effects of Bitter Taste Receptors on [Ca2+]i Mobilization, Hyperpolarization, and Relaxation of Human Airway Smooth Muscle Cells. Plos One. 10: e0131582. PMID 26121686 DOI: 10.1371/journal.pone.0131582  0.4
2015 Fox CS, Hall JL, Arnett DK, Ashley EA, Delles C, Engler MB, Freeman MW, Johnson JA, Lanfear DE, Liggett SB, Lusis AJ, Loscalzo J, MacRae CA, Musunuru K, Newby LK, et al. Future translational applications from the contemporary genomics era: a scientific statement from the American Heart Association. Circulation. 131: 1715-36. PMID 25882488 DOI: 10.1161/CIR.0000000000000211  0.4
2014 Wang WC, Pauer SH, Smith DC, Dixon MA, Disimile DJ, Panebra A, An SS, Camoretti-Mercado B, Liggett SB. Targeted transgenesis identifies Gαs as the bottleneck in β2-adrenergic receptor cell signaling and physiological function in airway smooth muscle. American Journal of Physiology. Lung Cellular and Molecular Physiology. 307: L775-80. PMID 25260754 DOI: 10.1152/ajplung.00209.2014  0.4
2014 Robinett KS, Koziol-White CJ, Akoluk A, An SS, Panettieri RA, Liggett SB. Bitter taste receptor function in asthmatic and nonasthmatic human airway smooth muscle cells. American Journal of Respiratory Cell and Molecular Biology. 50: 678-83. PMID 24219573 DOI: 10.1165/rcmb.2013-0439RC  0.4
2013 Aleong RG, Sauer WH, Sauer WH, Murphy GA, Port JD, Anand IS, Fiuzat M, O'Connor CM, Abraham WT, Liggett SB, Bristow MR. Prevention of atrial fibrillation by bucindolol is dependent on the beta₁389 Arg/Gly adrenergic receptor polymorphism. Jacc. Heart Failure. 1: 338-44. PMID 24159564 DOI: 10.1016/j.jchf.2013.04.002  0.4
2013 Aleong RG, Sauer WH, Robertson AD, Liggett SB, Bristow MR. Adrenergic receptor polymorphisms and prevention of ventricular arrhythmias with bucindolol in patients with chronic heart failure Circulation: Arrhythmia and Electrophysiology. 6: 137-143. PMID 23275278 DOI: 10.1161/CIRCEP.111.969618  0.4
2012 O'Connor CM, Fiuzat M, Carson PE, Anand IS, Plehn JF, Gottlieb SS, Silver MA, Lindenfeld J, Miller AB, White M, Walsh R, Nelson P, Medway A, Davis G, Robertson AD, ... ... Liggett SB, et al. Combinatorial pharmacogenetic interactions of bucindolol and β1, α2C adrenergic receptor polymorphisms. Plos One. 7: e44324. PMID 23071495 DOI: 10.1371/journal.pone.0044324  0.4
2012 Clark AA, Liggett SB, Munger SD. Extraoral bitter taste receptors as mediators of off-target drug effects. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 26: 4827-31. PMID 22964302 DOI: 10.1096/fj.12-215087  0.4
2012 Vandell AG, Lobmeyer MT, Gawronski BE, Langaee TY, Gong Y, Gums JG, Beitelshees AL, Turner ST, Chapman AB, Cooper-DeHoff RM, Bailey KR, Boerwinkle E, Pepine CJ, Liggett SB, Johnson JA. G protein receptor kinase 4 polymorphisms: β-blocker pharmacogenetics and treatment-related outcomes in hypertension. Hypertension. 60: 957-64. PMID 22949529 DOI: 10.1161/HYPERTENSIONAHA.112.198721  0.4
2012 An SS, Wang WC, Koziol-White CJ, Ahn K, Lee DY, Kurten RC, Panettieri RA, Liggett SB. TAS2R activation promotes airway smooth muscle relaxation despite β(2)-adrenergic receptor tachyphylaxis. American Journal of Physiology. Lung Cellular and Molecular Physiology. 303: L304-11. PMID 22683571 DOI: 10.1152/ajplung.00126.2012  0.4
2012 An SS, Robinett KS, Deshpande DA, Wang WC, Liggett SB. Reply to: Activation of BK channels may not be required for bitter tastant-induced bronchodilation. Nature Medicine. 18: 650-1. PMID 22561815 DOI: 10.1038/nm.2734  0.4
2011 Robinett KS, Deshpande DA, Malone MM, Liggett SB. Agonist-promoted homologous desensitization of human airway smooth muscle bitter taste receptors. American Journal of Respiratory Cell and Molecular Biology. 45: 1069-74. PMID 21642585 DOI: 10.1165/rcmb.2011-0061OC  0.4
2011 Parsa A, Chang YP, Kelly RJ, Corretti MC, Ryan KA, Robinson SW, Gottlieb SS, Kardia SL, Shuldiner AR, Liggett SB. Hypertrophy-associated polymorphisms ascertained in a founder cohort applied to heart failure risk and mortality. Clinical and Translational Science. 4: 17-23. PMID 21348951 DOI: 10.1111/j.1752-8062.2010.00251.x  0.4
2011 Duan QL, Gaume BR, Hawkins GA, Himes BE, Bleecker ER, Klanderman B, Irvin CG, Peters SP, Meyers DA, Hanrahan JP, Lima JJ, Litonjua AA, Tantisira KG, Liggett SB. Regulatory haplotypes in ARG1 are associated with altered bronchodilator response. American Journal of Respiratory and Critical Care Medicine. 183: 449-54. PMID 20851928 DOI: 10.1164/rccm.201005-0758OC  0.4
2010 Deshpande DA, Wang WC, McIlmoyle EL, Robinett KS, Schillinger RM, An SS, Sham JS, Liggett SB. Bitter taste receptors on airway smooth muscle bronchodilate by localized calcium signaling and reverse obstruction. Nature Medicine. 16: 1299-304. PMID 20972434 DOI: 10.1038/nm.2237  0.4
2010 Panebra A, Wang WC, Malone MM, Pitter DR, Weiss ST, Hawkins GA, Liggett SB. Common ADRB2 haplotypes derived from 26 polymorphic sites direct beta2-adrenergic receptor expression and regulation phenotypes. Plos One. 5: e11819. PMID 20686604 DOI: 10.1371/journal.pone.0011819  0.4
2010 Rajan S, Jagatheesan G, Karam CN, Alves ML, Bodi I, Schwartz A, Bulcao CF, D'Souza KM, Akhter SA, Boivin GP, Dube DK, Petrashevskaya N, Herr AB, Hullin R, Liggett SB, et al. Molecular and functional characterization of a novel cardiac-specific human tropomyosin isoform. Circulation. 121: 410-8. PMID 20065163 DOI: 10.1161/CIRCULATIONAHA.109.889725  0.4
2010 Bristow MR, Murphy GA, Krause-Steinrauf H, Anderson JL, Carlquist JF, Thaneemit-Chen S, Krishnan V, Abraham WT, Lowes BD, Port JD, Davis GW, Lazzeroni LC, Robertson AD, Lavori PW, Liggett SB. An alpha2C-adrenergic receptor polymorphism alters the norepinephrine-lowering effects and therapeutic response of the beta-blocker bucindolol in chronic heart failure. Circulation. Heart Failure. 3: 21-8. PMID 19880803 DOI: 10.1161/CIRCHEARTFAILURE.109.885962  0.4
2009 Dorn GW, Liggett SB. Mechanisms of pharmacogenomic effects of genetic variation within the cardiac adrenergic network in heart failure. Molecular Pharmacology. 76: 466-80. PMID 19491328 DOI: 10.1124/mol.109.056572  0.36
2009 Jagatheesan G, Rajan S, Schulz EM, Ahmed RP, Petrashevskaya N, Schwartz A, Boivin GP, Arteaga GM, Wang T, Wang YG, Ashraf M, Liggett SB, Lorenz J, Solaro RJ, Wieczorek DF. An internal domain of beta-tropomyosin increases myofilament Ca(2+) sensitivity. American Journal of Physiology. Heart and Circulatory Physiology. 297: H181-90. PMID 19429821 DOI: 10.1152/ajpheart.00329.2008  0.4
2008 Dorn GW, Liggett SB. Pharmacogenomics of beta-adrenergic receptors and their accessory signaling proteins in heart failure. Clinical and Translational Science. 1: 255-62. PMID 20443857 DOI: 10.1111/j.1752-8062.2008.00059.x  0.36
2008 Petrashevskaya N, Gaume BR, Mihlbachler KA, Dorn GW, Liggett SB. Bitransgenesis with beta(2)-adrenergic receptors or adenylyl cyclase fails to improve beta(1)-adrenergic receptor cardiomyopathy. Clinical and Translational Science. 1: 221-7. PMID 20443853 DOI: 10.1111/j.1752-8062.2008.00061.x  0.36
2008 Sehnert AJ, Daniels SE, Elashoff M, Wingrove JA, Burrow CR, Horne B, Muhlestein JB, Donahue M, Liggett SB, Anderson JL, Kraus WE. Lack of association between adrenergic receptor genotypes and survival in heart failure patients treated with carvedilol or metoprolol. Journal of the American College of Cardiology. 52: 644-51. PMID 18702968 DOI: 10.1016/j.jacc.2008.05.022  0.4
2008 Litonjua AA, Lasky-Su J, Schneiter K, Tantisira KG, Lazarus R, Klanderman B, Lima JJ, Irvin CG, Peters SP, Hanrahan JP, Liggett SB, Hawkins GA, Meyers DA, Bleecker ER, Lange C, et al. ARG1 is a novel bronchodilator response gene: screening and replication in four asthma cohorts. American Journal of Respiratory and Critical Care Medicine. 178: 688-94. PMID 18617639 DOI: 10.1164/rccm.200709-1363OC  0.4
2008 Liggett SB, Cresci S, Kelly RJ, Syed FM, Matkovich SJ, Hahn HS, Diwan A, Martini JS, Sparks L, Parekh RR, Spertus JA, Koch WJ, Kardia SL, Dorn GW. A GRK5 polymorphism that inhibits beta-adrenergic receptor signaling is protective in heart failure. Nature Medicine. 14: 510-7. PMID 18425130 DOI: 10.1038/nm1750  0.4
2007 Liggett SB, Kelly RJ, Parekh RR, Matkovich SJ, Benner BJ, Hahn HS, Syed FM, Galvez AS, Case KL, McGuire N, Odley AM, Sparks L, Kardia SL, Dorn GW. A functional polymorphism of the Galphaq (GNAQ) gene is associated with accelerated mortality in African-American heart failure. Human Molecular Genetics. 16: 2740-50. PMID 17720980 DOI: 10.1093/hmg/ddm229  0.36
2007 Jagatheesan G, Rajan S, Petrashevskaya N, Schwartz A, Boivin G, Arteaga GM, Solaro RJ, Liggett SB, Wieczorek DF. Rescue of tropomyosin-induced familial hypertrophic cardiomyopathy mice by transgenesis. American Journal of Physiology. Heart and Circulatory Physiology. 293: H949-58. PMID 17416600 DOI: 10.1152/ajpheart.01341.2006  0.4
2007 McGraw DW, Elwing JM, Fogel KM, Wang WC, Glinka CB, Mihlbachler KA, Rothenberg ME, Liggett SB. Crosstalk between Gi and Gq/Gs pathways in airway smooth muscle regulates bronchial contractility and relaxation. The Journal of Clinical Investigation. 117: 1391-8. PMID 17415415 DOI: 10.1172/JCI30489  0.4
2006 McGraw DW, Fogel KM, Kong S, Litonjua AA, Kranias EG, Aronow BJ, Liggett SB. Transcriptional response to persistent beta2-adrenergic receptor signaling reveals regulation of phospholamban, which alters airway contractility. Physiological Genomics. 27: 171-7. PMID 16849635 DOI: 10.1152/physiolgenomics.00044.2006  0.4
2006 Liggett SB, Mialet-Perez J, Thaneemit-Chen S, Weber SA, Greene SM, Hodne D, Nelson B, Morrison J, Domanski MJ, Wagoner LE, Abraham WT, Anderson JL, Carlquist JF, Krause-Steinrauf HJ, Lazzeroni LC, et al. A polymorphism within a conserved beta(1)-adrenergic receptor motif alters cardiac function and beta-blocker response in human heart failure. Proceedings of the National Academy of Sciences of the United States of America. 103: 11288-93. PMID 16844790 DOI: 10.1073/pnas.0509937103  0.4
2006 Small KM, Schwarb MR, Glinka C, Theiss CT, Brown KM, Seman CA, Liggett SB. Alpha2A- and alpha2C-adrenergic receptors form homo- and heterodimers: the heterodimeric state impairs agonist-promoted GRK phosphorylation and beta-arrestin recruitment. Biochemistry. 45: 4760-7. PMID 16605244 DOI: 10.1021/bi052074z  0.48
2006 Small KM, Brown KM, Seman CA, Theiss CT, Liggett SB. Complex haplotypes derived from noncoding polymorphisms of the intronless alpha2A-adrenergic gene diversify receptor expression. Proceedings of the National Academy of Sciences of the United States of America. 103: 5472-7. PMID 16567612 DOI: 10.1073/pnas.0601345103  0.48
2006 Akhter SA, D'Souza KM, Petrashevskaya NN, Mialet-Perez J, Liggett SB. Myocardial β1-adrenergic receptor polymorphisms affect functional recovery after ischemic injury American Journal of Physiology - Heart and Circulatory Physiology. 290. PMID 16537791 DOI: 10.1152/ajpheart.00908.2005  0.4
2006 Zhao W, Yuan Q, Qian J, Waggoner JR, Pathak A, Chu G, Mitton B, Sun X, Jin J, Braz JC, Hahn HS, Marreez Y, Syed F, Pollesello P, Annila A, ... ... Liggett SB, et al. The presence of Lys27 instead of Asn27 in human phospholamban promotes sarcoplasmic reticulum Ca2+-ATPase superinhibition and cardiac remodeling. Circulation. 113: 995-1004. PMID 16476846 DOI: 10.1161/CIRCULATIONAHA.105.583351  0.4
2004 Israel E, Chinchilli VM, Ford JG, Boushey HA, Cherniack R, Craig TJ, Deykin A, Fagan JK, Fahy JV, Fish J, Kraft M, Kunselman SJ, Lazarus SC, Lemanske RF, Liggett SB, et al. Use of regularly scheduled albuterol treatment in asthma: genotype-stratified, randomised, placebo-controlled cross-over trial. Lancet (London, England). 364: 1505-12. PMID 15500895 DOI: 10.1016/S0140-6736(04)17273-5  0.4
2004 Small KM, Mialet-Perez J, Seman CA, Theiss CT, Brown KM, Liggett SB. Polymorphisms of cardiac presynaptic alpha2C adrenergic receptors: Diverse intragenic variability with haplotype-specific functional effects. Proceedings of the National Academy of Sciences of the United States of America. 101: 13020-5. PMID 15319474 DOI: 10.1073/pnas.0405074101  0.48
2004 Mialet-Perez J, Green SA, Miller WE, Liggett SB. A primate-dominant third glycosylation site of the beta2-adrenergic receptor routes receptors to degradation during agonist regulation. The Journal of Biological Chemistry. 279: 38603-7. PMID 15247302 DOI: 10.1074/jbc.M403708200  0.4
2004 Braz JC, Gregory K, Pathak A, Zhao W, Sahin B, Klevitsky R, Kimball TF, Lorenz JN, Nairn AC, Liggett SB, Bodi I, Wang S, Schwartz A, Lakatta EG, DePaoli-Roach AA, et al. PKC-alpha regulates cardiac contractility and propensity toward heart failure. Nature Medicine. 10: 248-54. PMID 14966518 DOI: 10.1038/nm1000  0.4
2004 Lalchandani SG, Zhang X, Hong SS, Liggett SB, Li W, Moore BM, Miller DD, Feller DR. Medetomidine analogs as selective agonists for the human alpha2-adrenoceptors. Biochemical Pharmacology. 67: 87-96. PMID 14667931 DOI: 10.1016/j.bcp.2003.08.043  0.4
2003 Gaussin V, Tomlinson JE, Depre C, Engelhardt S, Antos CL, Takagi G, Hein L, Topper JN, Liggett SB, Olson EN, Lohse MJ, Vatner SF, Vatner DE. Common genomic response in different mouse models of beta-adrenergic-induced cardiomyopathy. Circulation. 108: 2926-33. PMID 14623810 DOI: 10.1161/01.CIR.0000101922.18151.7B  0.4
2003 Hahn HS, Marreez Y, Odley A, Sterbling A, Yussman MG, Hilty KC, Bodi I, Liggett SB, Schwartz A, Dorn GW. Protein kinase Calpha negatively regulates systolic and diastolic function in pathological hypertrophy. Circulation Research. 93: 1111-9. PMID 14605019 DOI: 10.1161/01.RES.0000105087.79373.17  0.4
2003 Mialet Perez J, Rathz DA, Petrashevskaya NN, Hahn HS, Wagoner LE, Schwartz A, Dorn GW, Liggett SB. Beta 1-adrenergic receptor polymorphisms confer differential function and predisposition to heart failure. Nature Medicine. 9: 1300-5. PMID 14502278 DOI: 10.1038/nm930  0.4
2003 Small KM, Brown KM, Theiss CT, Seman CA, Weiss ST, Liggett SB. An Ile to Met polymorphism in the catalytic domain of adenylyl cyclase type 9 confers reduced beta2-adrenergic receptor stimulation. Pharmacogenetics. 13: 535-41. PMID 12972952 DOI: 10.1097/01.fpc.0000054119.14659.01  0.48
2003 McGraw DW, Almoosa KF, Paul RJ, Kobilka BK, Liggett SB. Antithetic regulation by beta-adrenergic receptors of Gq receptor signaling via phospholipase C underlies the airway beta-agonist paradox. The Journal of Clinical Investigation. 112: 619-26. PMID 12925702 DOI: 10.1172/JCI18193  0.4
2003 Cuajungco MP, Ando Y, Axelrod FB, Biaggioni I, Goldstein DS, Guttmacher AE, Gwinn-Hardy K, Hahn MK, Hilz MJ, Jacob G, Jens J, Kennedy WR, Liggett SB, O'Connor DT, Peltzer SR, et al. Hereditary dysautonomias: current knowledge and collaborations for the future. Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society. 13: 180-95. PMID 12822040 DOI: 10.1007/s10286-003-0098-2  0.4
2003 Haghighi K, Kolokathis F, Pater L, Lynch RA, Asahi M, Gramolini AO, Fan GC, Tsiapras D, Hahn HS, Adamopoulos S, Liggett SB, Dorn GW, MacLennan DH, Kremastinos DT, Kranias EG. Human phospholamban null results in lethal dilated cardiomyopathy revealing a critical difference between mouse and human. The Journal of Clinical Investigation. 111: 869-76. PMID 12639993 DOI: 10.1172/JCI17892  0.4
2003 Small KM, Tanguay DA, Nandabalan K, Zhan P, Stephens JC, Liggett SB. Gene and protein domain-specific patterns of genetic variability within the G-protein coupled receptor superfamily. American Journal of Pharmacogenomics : Genomics-Related Research in Drug Development and Clinical Practice. 3: 65-71. PMID 12562217 DOI: 10.2165/00129785-200303010-00008  0.4
2003 Rathz DA, Gregory KN, Fang Y, Brown KM, Liggett SB. Hierarchy of polymorphic variation and desensitization permutations relative to beta 1- and beta 2-adrenergic receptor signaling. The Journal of Biological Chemistry. 278: 10784-9. PMID 12525504 DOI: 10.1074/jbc.M206054200  0.4
2002 Lalchandani SG, Lei L, Zheng W, Suni MM, Moore BM, Liggett SB, Miller DD, Feller DR. Yohimbine dimers exhibiting selectivity for the human alpha 2C-adrenoceptor subtype. The Journal of Pharmacology and Experimental Therapeutics. 303: 979-84. PMID 12438517 DOI: 10.1124/jpet.102.039057  0.4
2002 Wagoner LE, Craft LL, Zengel P, McGuire N, Rathz DA, Dorn GW, Liggett SB. Polymorphisms of the beta1-adrenergic receptor predict exercise capacity in heart failure. American Heart Journal. 144: 840-6. PMID 12422153  0.4
2002 Small KM, Wagoner LE, Levin AM, Kardia SL, Liggett SB. Synergistic polymorphisms of beta1- and alpha2C-adrenergic receptors and the risk of congestive heart failure. The New England Journal of Medicine. 347: 1135-42. PMID 12374873 DOI: 10.1056/NEJMoa020803  0.4
2002 Liang M, Eason MG, Theiss CT, Liggett SB. Phosphorylation of Ser360 in the third intracellular loop of the alpha2A-adrenoceptor during protein kinase C-mediated desensitization. European Journal of Pharmacology. 437: 41-6. PMID 11864637  0.48
2002 Rathz DA, Brown KM, Kramer LA, Liggett SB. Amino acid 49 polymorphisms of the human beta1-adrenergic receptor affect agonist-promoted trafficking. Journal of Cardiovascular Pharmacology. 39: 155-60. PMID 11791000 DOI: 10.1097/00005344-200202000-00001  0.4
2002 Small KM, Rathz DA, Liggett SB. Identification of adrenergic receptor polymorphisms. Methods in Enzymology. 343: 459-75. PMID 11665585  0.4
2001 Liang M, Freedman NJ, Theiss CT, Liggett SB. Serine 232 of the alpha(2A)-adrenergic receptor is a protein kinase C-sensitive effector coupling switch. Biochemistry. 40: 15031-7. PMID 11732925  0.48
2001 Green SA, Rathz DA, Schuster AJ, Liggett SB. The Ile164 β2-adrenoceptor polymorphism alters salmeterol exosite binding and conventional agonist coupling to Gs European Journal of Pharmacology. 421: 141-147. PMID 11516429 DOI: 10.1016/S0014-2999(01)01049-4  0.4
1998 Liang M, Eason MG, Jewell-Motz EA, Williams MA, Theiss CT, Dorn GW, Liggett SB. Phosphorylation and functional desensitization of the alpha2A-adrenergic receptor by protein kinase C. Molecular Pharmacology. 54: 44-9. PMID 9658188  0.48
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