Stephen B. Liggett - Publications

Affiliations: 
University of Cincinnati, Cincinnati, OH 
Area:
Pharmacology, Molecular Biology

58/125 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 An SS, Mitzner W, Tang WY, Ahn K, Yoon AR, Huang J, Kilic O, Yong HM, Fahey JW, Kumar S, Biswal S, Holgate ST, Panettieri RA, Solway J, Liggett SB. An inflammation-independent contraction mechanophenotype of airway smooth muscle in asthma. The Journal of Allergy and Clinical Immunology. PMID 26936804 DOI: 10.1016/j.jaci.2015.12.1315  0.4
2015 Camoretti-Mercado B, Pauer SH, Yong HM, Smith DC, Deshpande DA, An SS, Liggett SB. Pleiotropic Effects of Bitter Taste Receptors on [Ca2+]i Mobilization, Hyperpolarization, and Relaxation of Human Airway Smooth Muscle Cells. Plos One. 10: e0131582. PMID 26121686 DOI: 10.1371/journal.pone.0131582  0.4
2015 Fox CS, Hall JL, Arnett DK, Ashley EA, Delles C, Engler MB, Freeman MW, Johnson JA, Lanfear DE, Liggett SB, Lusis AJ, Loscalzo J, MacRae CA, Musunuru K, Newby LK, et al. Future translational applications from the contemporary genomics era: a scientific statement from the American Heart Association. Circulation. 131: 1715-36. PMID 25882488 DOI: 10.1161/CIR.0000000000000211  0.4
2014 Wang WC, Pauer SH, Smith DC, Dixon MA, Disimile DJ, Panebra A, An SS, Camoretti-Mercado B, Liggett SB. Targeted transgenesis identifies Gαs as the bottleneck in β2-adrenergic receptor cell signaling and physiological function in airway smooth muscle. American Journal of Physiology. Lung Cellular and Molecular Physiology. 307: L775-80. PMID 25260754 DOI: 10.1152/ajplung.00209.2014  0.4
2014 Robinett KS, Koziol-White CJ, Akoluk A, An SS, Panettieri RA, Liggett SB. Bitter taste receptor function in asthmatic and nonasthmatic human airway smooth muscle cells. American Journal of Respiratory Cell and Molecular Biology. 50: 678-83. PMID 24219573 DOI: 10.1165/rcmb.2013-0439RC  0.4
2013 Aleong RG, Sauer WH, Sauer WH, Murphy GA, Port JD, Anand IS, Fiuzat M, O'Connor CM, Abraham WT, Liggett SB, Bristow MR. Prevention of atrial fibrillation by bucindolol is dependent on the beta₁389 Arg/Gly adrenergic receptor polymorphism. Jacc. Heart Failure. 1: 338-44. PMID 24159564 DOI: 10.1016/j.jchf.2013.04.002  0.4
2013 Aleong RG, Sauer WH, Robertson AD, Liggett SB, Bristow MR. Adrenergic receptor polymorphisms and prevention of ventricular arrhythmias with bucindolol in patients with chronic heart failure Circulation: Arrhythmia and Electrophysiology. 6: 137-143. PMID 23275278 DOI: 10.1161/CIRCEP.111.969618  0.4
2012 O'Connor CM, Fiuzat M, Carson PE, Anand IS, Plehn JF, Gottlieb SS, Silver MA, Lindenfeld J, Miller AB, White M, Walsh R, Nelson P, Medway A, Davis G, Robertson AD, ... ... Liggett SB, et al. Combinatorial pharmacogenetic interactions of bucindolol and β1, α2C adrenergic receptor polymorphisms. Plos One. 7: e44324. PMID 23071495 DOI: 10.1371/journal.pone.0044324  0.4
2012 Clark AA, Liggett SB, Munger SD. Extraoral bitter taste receptors as mediators of off-target drug effects. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 26: 4827-31. PMID 22964302 DOI: 10.1096/fj.12-215087  0.4
2012 Vandell AG, Lobmeyer MT, Gawronski BE, Langaee TY, Gong Y, Gums JG, Beitelshees AL, Turner ST, Chapman AB, Cooper-DeHoff RM, Bailey KR, Boerwinkle E, Pepine CJ, Liggett SB, Johnson JA. G protein receptor kinase 4 polymorphisms: β-blocker pharmacogenetics and treatment-related outcomes in hypertension. Hypertension. 60: 957-64. PMID 22949529 DOI: 10.1161/HYPERTENSIONAHA.112.198721  0.4
2012 An SS, Wang WC, Koziol-White CJ, Ahn K, Lee DY, Kurten RC, Panettieri RA, Liggett SB. TAS2R activation promotes airway smooth muscle relaxation despite β(2)-adrenergic receptor tachyphylaxis. American Journal of Physiology. Lung Cellular and Molecular Physiology. 303: L304-11. PMID 22683571 DOI: 10.1152/ajplung.00126.2012  0.4
2012 An SS, Robinett KS, Deshpande DA, Wang WC, Liggett SB. Reply to: Activation of BK channels may not be required for bitter tastant-induced bronchodilation. Nature Medicine. 18: 650-1. PMID 22561815 DOI: 10.1038/nm.2734  0.4
2011 Robinett KS, Deshpande DA, Malone MM, Liggett SB. Agonist-promoted homologous desensitization of human airway smooth muscle bitter taste receptors. American Journal of Respiratory Cell and Molecular Biology. 45: 1069-74. PMID 21642585 DOI: 10.1165/rcmb.2011-0061OC  0.4
2011 Parsa A, Chang YP, Kelly RJ, Corretti MC, Ryan KA, Robinson SW, Gottlieb SS, Kardia SL, Shuldiner AR, Liggett SB. Hypertrophy-associated polymorphisms ascertained in a founder cohort applied to heart failure risk and mortality. Clinical and Translational Science. 4: 17-23. PMID 21348951 DOI: 10.1111/j.1752-8062.2010.00251.x  0.4
2011 Duan QL, Gaume BR, Hawkins GA, Himes BE, Bleecker ER, Klanderman B, Irvin CG, Peters SP, Meyers DA, Hanrahan JP, Lima JJ, Litonjua AA, Tantisira KG, Liggett SB. Regulatory haplotypes in ARG1 are associated with altered bronchodilator response. American Journal of Respiratory and Critical Care Medicine. 183: 449-54. PMID 20851928 DOI: 10.1164/rccm.201005-0758OC  0.4
2010 Deshpande DA, Wang WC, McIlmoyle EL, Robinett KS, Schillinger RM, An SS, Sham JS, Liggett SB. Bitter taste receptors on airway smooth muscle bronchodilate by localized calcium signaling and reverse obstruction. Nature Medicine. 16: 1299-304. PMID 20972434 DOI: 10.1038/nm.2237  0.4
2010 Panebra A, Wang WC, Malone MM, Pitter DR, Weiss ST, Hawkins GA, Liggett SB. Common ADRB2 haplotypes derived from 26 polymorphic sites direct beta2-adrenergic receptor expression and regulation phenotypes. Plos One. 5: e11819. PMID 20686604 DOI: 10.1371/journal.pone.0011819  0.4
2010 Rajan S, Jagatheesan G, Karam CN, Alves ML, Bodi I, Schwartz A, Bulcao CF, D'Souza KM, Akhter SA, Boivin GP, Dube DK, Petrashevskaya N, Herr AB, Hullin R, Liggett SB, et al. Molecular and functional characterization of a novel cardiac-specific human tropomyosin isoform. Circulation. 121: 410-8. PMID 20065163 DOI: 10.1161/CIRCULATIONAHA.109.889725  0.4
2010 Bristow MR, Murphy GA, Krause-Steinrauf H, Anderson JL, Carlquist JF, Thaneemit-Chen S, Krishnan V, Abraham WT, Lowes BD, Port JD, Davis GW, Lazzeroni LC, Robertson AD, Lavori PW, Liggett SB. An alpha2C-adrenergic receptor polymorphism alters the norepinephrine-lowering effects and therapeutic response of the beta-blocker bucindolol in chronic heart failure. Circulation. Heart Failure. 3: 21-8. PMID 19880803 DOI: 10.1161/CIRCHEARTFAILURE.109.885962  0.4
2009 Dorn GW, Liggett SB. Mechanisms of pharmacogenomic effects of genetic variation within the cardiac adrenergic network in heart failure. Molecular Pharmacology. 76: 466-80. PMID 19491328 DOI: 10.1124/mol.109.056572  0.36
2009 Jagatheesan G, Rajan S, Schulz EM, Ahmed RP, Petrashevskaya N, Schwartz A, Boivin GP, Arteaga GM, Wang T, Wang YG, Ashraf M, Liggett SB, Lorenz J, Solaro RJ, Wieczorek DF. An internal domain of beta-tropomyosin increases myofilament Ca(2+) sensitivity. American Journal of Physiology. Heart and Circulatory Physiology. 297: H181-90. PMID 19429821 DOI: 10.1152/ajpheart.00329.2008  0.4
2008 Dorn GW, Liggett SB. Pharmacogenomics of beta-adrenergic receptors and their accessory signaling proteins in heart failure. Clinical and Translational Science. 1: 255-62. PMID 20443857 DOI: 10.1111/j.1752-8062.2008.00059.x  0.36
2008 Petrashevskaya N, Gaume BR, Mihlbachler KA, Dorn GW, Liggett SB. Bitransgenesis with beta(2)-adrenergic receptors or adenylyl cyclase fails to improve beta(1)-adrenergic receptor cardiomyopathy. Clinical and Translational Science. 1: 221-7. PMID 20443853 DOI: 10.1111/j.1752-8062.2008.00061.x  0.36
2008 Sehnert AJ, Daniels SE, Elashoff M, Wingrove JA, Burrow CR, Horne B, Muhlestein JB, Donahue M, Liggett SB, Anderson JL, Kraus WE. Lack of association between adrenergic receptor genotypes and survival in heart failure patients treated with carvedilol or metoprolol. Journal of the American College of Cardiology. 52: 644-51. PMID 18702968 DOI: 10.1016/j.jacc.2008.05.022  0.4
2008 Litonjua AA, Lasky-Su J, Schneiter K, Tantisira KG, Lazarus R, Klanderman B, Lima JJ, Irvin CG, Peters SP, Hanrahan JP, Liggett SB, Hawkins GA, Meyers DA, Bleecker ER, Lange C, et al. ARG1 is a novel bronchodilator response gene: screening and replication in four asthma cohorts. American Journal of Respiratory and Critical Care Medicine. 178: 688-94. PMID 18617639 DOI: 10.1164/rccm.200709-1363OC  0.4
2008 Liggett SB, Cresci S, Kelly RJ, Syed FM, Matkovich SJ, Hahn HS, Diwan A, Martini JS, Sparks L, Parekh RR, Spertus JA, Koch WJ, Kardia SL, Dorn GW. A GRK5 polymorphism that inhibits beta-adrenergic receptor signaling is protective in heart failure. Nature Medicine. 14: 510-7. PMID 18425130 DOI: 10.1038/nm1750  0.4
2007 Liggett SB, Kelly RJ, Parekh RR, Matkovich SJ, Benner BJ, Hahn HS, Syed FM, Galvez AS, Case KL, McGuire N, Odley AM, Sparks L, Kardia SL, Dorn GW. A functional polymorphism of the Galphaq (GNAQ) gene is associated with accelerated mortality in African-American heart failure. Human Molecular Genetics. 16: 2740-50. PMID 17720980 DOI: 10.1093/hmg/ddm229  0.36
2007 Jagatheesan G, Rajan S, Petrashevskaya N, Schwartz A, Boivin G, Arteaga GM, Solaro RJ, Liggett SB, Wieczorek DF. Rescue of tropomyosin-induced familial hypertrophic cardiomyopathy mice by transgenesis. American Journal of Physiology. Heart and Circulatory Physiology. 293: H949-58. PMID 17416600 DOI: 10.1152/ajpheart.01341.2006  0.4
2007 McGraw DW, Elwing JM, Fogel KM, Wang WC, Glinka CB, Mihlbachler KA, Rothenberg ME, Liggett SB. Crosstalk between Gi and Gq/Gs pathways in airway smooth muscle regulates bronchial contractility and relaxation. The Journal of Clinical Investigation. 117: 1391-8. PMID 17415415 DOI: 10.1172/JCI30489  0.4
2006 McGraw DW, Fogel KM, Kong S, Litonjua AA, Kranias EG, Aronow BJ, Liggett SB. Transcriptional response to persistent beta2-adrenergic receptor signaling reveals regulation of phospholamban, which alters airway contractility. Physiological Genomics. 27: 171-7. PMID 16849635 DOI: 10.1152/physiolgenomics.00044.2006  0.4
2006 Liggett SB, Mialet-Perez J, Thaneemit-Chen S, Weber SA, Greene SM, Hodne D, Nelson B, Morrison J, Domanski MJ, Wagoner LE, Abraham WT, Anderson JL, Carlquist JF, Krause-Steinrauf HJ, Lazzeroni LC, et al. A polymorphism within a conserved beta(1)-adrenergic receptor motif alters cardiac function and beta-blocker response in human heart failure. Proceedings of the National Academy of Sciences of the United States of America. 103: 11288-93. PMID 16844790 DOI: 10.1073/pnas.0509937103  0.4
2006 Small KM, Schwarb MR, Glinka C, Theiss CT, Brown KM, Seman CA, Liggett SB. Alpha2A- and alpha2C-adrenergic receptors form homo- and heterodimers: the heterodimeric state impairs agonist-promoted GRK phosphorylation and beta-arrestin recruitment. Biochemistry. 45: 4760-7. PMID 16605244 DOI: 10.1021/bi052074z  0.48
2006 Small KM, Brown KM, Seman CA, Theiss CT, Liggett SB. Complex haplotypes derived from noncoding polymorphisms of the intronless alpha2A-adrenergic gene diversify receptor expression. Proceedings of the National Academy of Sciences of the United States of America. 103: 5472-7. PMID 16567612 DOI: 10.1073/pnas.0601345103  0.48
2006 Akhter SA, D'Souza KM, Petrashevskaya NN, Mialet-Perez J, Liggett SB. Myocardial β1-adrenergic receptor polymorphisms affect functional recovery after ischemic injury American Journal of Physiology - Heart and Circulatory Physiology. 290. PMID 16537791 DOI: 10.1152/ajpheart.00908.2005  0.4
2006 Zhao W, Yuan Q, Qian J, Waggoner JR, Pathak A, Chu G, Mitton B, Sun X, Jin J, Braz JC, Hahn HS, Marreez Y, Syed F, Pollesello P, Annila A, ... ... Liggett SB, et al. The presence of Lys27 instead of Asn27 in human phospholamban promotes sarcoplasmic reticulum Ca2+-ATPase superinhibition and cardiac remodeling. Circulation. 113: 995-1004. PMID 16476846 DOI: 10.1161/CIRCULATIONAHA.105.583351  0.4
2004 Israel E, Chinchilli VM, Ford JG, Boushey HA, Cherniack R, Craig TJ, Deykin A, Fagan JK, Fahy JV, Fish J, Kraft M, Kunselman SJ, Lazarus SC, Lemanske RF, Liggett SB, et al. Use of regularly scheduled albuterol treatment in asthma: genotype-stratified, randomised, placebo-controlled cross-over trial. Lancet (London, England). 364: 1505-12. PMID 15500895 DOI: 10.1016/S0140-6736(04)17273-5  0.4
2004 Small KM, Mialet-Perez J, Seman CA, Theiss CT, Brown KM, Liggett SB. Polymorphisms of cardiac presynaptic alpha2C adrenergic receptors: Diverse intragenic variability with haplotype-specific functional effects. Proceedings of the National Academy of Sciences of the United States of America. 101: 13020-5. PMID 15319474 DOI: 10.1073/pnas.0405074101  0.48
2004 Mialet-Perez J, Green SA, Miller WE, Liggett SB. A primate-dominant third glycosylation site of the beta2-adrenergic receptor routes receptors to degradation during agonist regulation. The Journal of Biological Chemistry. 279: 38603-7. PMID 15247302 DOI: 10.1074/jbc.M403708200  0.4
2004 Braz JC, Gregory K, Pathak A, Zhao W, Sahin B, Klevitsky R, Kimball TF, Lorenz JN, Nairn AC, Liggett SB, Bodi I, Wang S, Schwartz A, Lakatta EG, DePaoli-Roach AA, et al. PKC-alpha regulates cardiac contractility and propensity toward heart failure. Nature Medicine. 10: 248-54. PMID 14966518 DOI: 10.1038/nm1000  0.4
2004 Lalchandani SG, Zhang X, Hong SS, Liggett SB, Li W, Moore BM, Miller DD, Feller DR. Medetomidine analogs as selective agonists for the human alpha2-adrenoceptors. Biochemical Pharmacology. 67: 87-96. PMID 14667931 DOI: 10.1016/j.bcp.2003.08.043  0.4
2003 Gaussin V, Tomlinson JE, Depre C, Engelhardt S, Antos CL, Takagi G, Hein L, Topper JN, Liggett SB, Olson EN, Lohse MJ, Vatner SF, Vatner DE. Common genomic response in different mouse models of beta-adrenergic-induced cardiomyopathy. Circulation. 108: 2926-33. PMID 14623810 DOI: 10.1161/01.CIR.0000101922.18151.7B  0.4
2003 Hahn HS, Marreez Y, Odley A, Sterbling A, Yussman MG, Hilty KC, Bodi I, Liggett SB, Schwartz A, Dorn GW. Protein kinase Calpha negatively regulates systolic and diastolic function in pathological hypertrophy. Circulation Research. 93: 1111-9. PMID 14605019 DOI: 10.1161/01.RES.0000105087.79373.17  0.4
2003 Mialet Perez J, Rathz DA, Petrashevskaya NN, Hahn HS, Wagoner LE, Schwartz A, Dorn GW, Liggett SB. Beta 1-adrenergic receptor polymorphisms confer differential function and predisposition to heart failure. Nature Medicine. 9: 1300-5. PMID 14502278 DOI: 10.1038/nm930  0.4
2003 Small KM, Brown KM, Theiss CT, Seman CA, Weiss ST, Liggett SB. An Ile to Met polymorphism in the catalytic domain of adenylyl cyclase type 9 confers reduced beta2-adrenergic receptor stimulation. Pharmacogenetics. 13: 535-41. PMID 12972952 DOI: 10.1097/01.fpc.0000054119.14659.01  0.48
2003 McGraw DW, Almoosa KF, Paul RJ, Kobilka BK, Liggett SB. Antithetic regulation by beta-adrenergic receptors of Gq receptor signaling via phospholipase C underlies the airway beta-agonist paradox. The Journal of Clinical Investigation. 112: 619-26. PMID 12925702 DOI: 10.1172/JCI18193  0.4
2003 Cuajungco MP, Ando Y, Axelrod FB, Biaggioni I, Goldstein DS, Guttmacher AE, Gwinn-Hardy K, Hahn MK, Hilz MJ, Jacob G, Jens J, Kennedy WR, Liggett SB, O'Connor DT, Peltzer SR, et al. Hereditary dysautonomias: current knowledge and collaborations for the future. Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society. 13: 180-95. PMID 12822040 DOI: 10.1007/s10286-003-0098-2  0.4
2003 Haghighi K, Kolokathis F, Pater L, Lynch RA, Asahi M, Gramolini AO, Fan GC, Tsiapras D, Hahn HS, Adamopoulos S, Liggett SB, Dorn GW, MacLennan DH, Kremastinos DT, Kranias EG. Human phospholamban null results in lethal dilated cardiomyopathy revealing a critical difference between mouse and human. The Journal of Clinical Investigation. 111: 869-76. PMID 12639993 DOI: 10.1172/JCI17892  0.4
2003 Small KM, Tanguay DA, Nandabalan K, Zhan P, Stephens JC, Liggett SB. Gene and protein domain-specific patterns of genetic variability within the G-protein coupled receptor superfamily. American Journal of Pharmacogenomics : Genomics-Related Research in Drug Development and Clinical Practice. 3: 65-71. PMID 12562217 DOI: 10.2165/00129785-200303010-00008  0.4
2003 Rathz DA, Gregory KN, Fang Y, Brown KM, Liggett SB. Hierarchy of polymorphic variation and desensitization permutations relative to beta 1- and beta 2-adrenergic receptor signaling. The Journal of Biological Chemistry. 278: 10784-9. PMID 12525504 DOI: 10.1074/jbc.M206054200  0.4
2002 Lalchandani SG, Lei L, Zheng W, Suni MM, Moore BM, Liggett SB, Miller DD, Feller DR. Yohimbine dimers exhibiting selectivity for the human alpha 2C-adrenoceptor subtype. The Journal of Pharmacology and Experimental Therapeutics. 303: 979-84. PMID 12438517 DOI: 10.1124/jpet.102.039057  0.4
2002 Wagoner LE, Craft LL, Zengel P, McGuire N, Rathz DA, Dorn GW, Liggett SB. Polymorphisms of the beta1-adrenergic receptor predict exercise capacity in heart failure. American Heart Journal. 144: 840-6. PMID 12422153  0.4
2002 Small KM, Wagoner LE, Levin AM, Kardia SL, Liggett SB. Synergistic polymorphisms of beta1- and alpha2C-adrenergic receptors and the risk of congestive heart failure. The New England Journal of Medicine. 347: 1135-42. PMID 12374873 DOI: 10.1056/NEJMoa020803  0.4
2002 Liang M, Eason MG, Theiss CT, Liggett SB. Phosphorylation of Ser360 in the third intracellular loop of the alpha2A-adrenoceptor during protein kinase C-mediated desensitization. European Journal of Pharmacology. 437: 41-6. PMID 11864637  0.48
2002 Rathz DA, Brown KM, Kramer LA, Liggett SB. Amino acid 49 polymorphisms of the human beta1-adrenergic receptor affect agonist-promoted trafficking. Journal of Cardiovascular Pharmacology. 39: 155-60. PMID 11791000 DOI: 10.1097/00005344-200202000-00001  0.4
2002 Small KM, Rathz DA, Liggett SB. Identification of adrenergic receptor polymorphisms. Methods in Enzymology. 343: 459-75. PMID 11665585  0.4
2001 Liang M, Freedman NJ, Theiss CT, Liggett SB. Serine 232 of the alpha(2A)-adrenergic receptor is a protein kinase C-sensitive effector coupling switch. Biochemistry. 40: 15031-7. PMID 11732925  0.48
2001 Green SA, Rathz DA, Schuster AJ, Liggett SB. The Ile164 β2-adrenoceptor polymorphism alters salmeterol exosite binding and conventional agonist coupling to Gs European Journal of Pharmacology. 421: 141-147. PMID 11516429 DOI: 10.1016/S0014-2999(01)01049-4  0.4
1998 Liang M, Eason MG, Jewell-Motz EA, Williams MA, Theiss CT, Dorn GW, Liggett SB. Phosphorylation and functional desensitization of the alpha2A-adrenergic receptor by protein kinase C. Molecular Pharmacology. 54: 44-9. PMID 9658188  0.48
Low-probability matches
2008 Swift SM, Gaume BR, Small KM, Aronow BJ, Liggett SB. Differential coupling of Arg- and Gly389 polymorphic forms of the beta1-adrenergic receptor leads to pathogenic cardiac gene regulatory programs. Physiological Genomics. 35: 123-31. PMID 18664629 DOI: 10.1152/physiolgenomics.90225.2008  0.28
2008 Small KM, Mialet-Perez J, Liggett SB. Genetic variation within the beta1-adrenergic receptor gene results in haplotype-specific expression phenotypes. Journal of Cardiovascular Pharmacology. 51: 106-10. PMID 18209576 DOI: 10.1097/FJC.0b013e31815a958f  0.28
2006 McGraw DW, Mihlbachler KA, Schwarb MR, Rahman FF, Small KM, Almoosa KF, Liggett SB. Airway smooth muscle prostaglandin-EP1 receptors directly modulate beta2-adrenergic receptors within a unique heterodimeric complex. The Journal of Clinical Investigation. 116: 1400-9. PMID 16670773 DOI: 10.1172/JCI25840  0.28
2005 Tantisira KG, Small KM, Litonjua AA, Weiss ST, Liggett SB. Molecular properties and pharmacogenetics of a polymorphism of adenylyl cyclase type 9 in asthma: interaction between beta-agonist and corticosteroid pathways. Human Molecular Genetics. 14: 1671-7. PMID 15879435 DOI: 10.1093/hmg/ddi175  0.28
2003 Small KM, McGraw DW, Liggett SB. Pharmacology and physiology of human adrenergic receptor polymorphisms. Annual Review of Pharmacology and Toxicology. 43: 381-411. PMID 12540746 DOI: 10.1146/annurev.pharmtox.43.100901.135823  0.28
2003 Gerson MC, Wagoner LE, McGuire N, Liggett SB. Activity of the uptake-1 norepinephrine transporter as measured by I-123 MIBG in heart failure patients with a loss-of-function polymorphism of the presynaptic alpha2C-adrenergic receptor. Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology. 10: 583-9. PMID 14668769 DOI: 10.1016/j.nuclcard.2003.07.001  0.2
2018 Parikh KS, Fiuzat M, Davis G, Neely M, Blain-Nelson P, Whellan DJ, Abraham WT, Adams KF, Felker GM, Liggett SB, O'Connor CM, Bristow MR. Dose Response of β-Blockers in Adrenergic Receptor Polymorphism Genotypes. Circulation. Genomic and Precision Medicine. 11: e002210. PMID 30354340 DOI: 10.1161/CIRCGEN.117.002210  0.04
2011 Dockstader K, Nunley K, Karimpour-Fard A, Medway A, Nelson P, Port JD, Liggett SB, Bristow MR, Sucharov CC. Temporal analysis of mRNA and miRNA expression in transgenic mice overexpressing Arg- and Gly389 polymorphic variants of the β1-adrenergic receptor. Physiological Genomics. 43: 1294-306. PMID 21954455 DOI: 10.1152/physiolgenomics.00067.2011  0.04
2008 Wang WC, Mihlbachler KA, Bleecker ER, Weiss ST, Liggett SB. A polymorphism of G-protein coupled receptor kinase5 alters agonist-promoted desensitization of beta2-adrenergic receptors. Pharmacogenetics and Genomics. 18: 729-32. PMID 18622265 DOI: 10.1097/FPC.0b013e32830967e9  0.04
2008 Panebra A, Schwarb MR, Swift SM, Weiss ST, Bleecker ER, Hawkins GA, Liggett SB. Variable-length poly-C tract polymorphisms of the beta2-adrenergic receptor 3'-UTR alter expression and agonist regulation. American Journal of Physiology. Lung Cellular and Molecular Physiology. 294: L190-5. PMID 18024720 DOI: 10.1152/ajplung.00277.2007  0.04
2007 Panebra A, Schwarb MR, Glinka CB, Liggett SB. Heterogeneity of transcription factor expression and regulation in human airway epithelial and smooth muscle cells. American Journal of Physiology. Lung Cellular and Molecular Physiology. 293: L453-62. PMID 17557803 DOI: 10.1152/ajplung.00084.2007  0.04
2007 Panebra A, Schwarb MR, Glinka CB, Liggett SB. Allele-specific binding of airway nuclear extracts to polymorphic beta2-adrenergic receptor 5' sequence. American Journal of Respiratory Cell and Molecular Biology. 36: 654-60. PMID 17255556 DOI: 10.1165/rcmb.2006-0394OC  0.04
2007 Swift SM, Schwarb MR, Mihlbachler KA, Liggett SB. Pleiotropic beta-agonist-promoted receptor conformations and signals independent of intrinsic activity. American Journal of Respiratory Cell and Molecular Biology. 36: 236-43. PMID 16980553 DOI: 10.1165/rcmb.2006-0257OC  0.04
2006 Hawkins GA, Tantisira K, Meyers DA, Ampleford EJ, Moore WC, Klanderman B, Liggett SB, Peters SP, Weiss ST, Bleecker ER. Sequence, haplotype, and association analysis of ADRbeta2 in a multiethnic asthma case-control study. American Journal of Respiratory and Critical Care Medicine. 174: 1101-9. PMID 16931635 DOI: 10.1164/rccm.200509-1405OC  0.04
2004 Tantisira KG, Lake S, Silverman ES, Palmer LJ, Lazarus R, Silverman EK, Liggett SB, Gelfand EW, Rosenwasser LJ, Richter B, Israel E, Wechsler M, Gabriel S, Altshuler D, Lander E, et al. Corticosteroid pharmacogenetics: association of sequence variants in CRHR1 with improved lung function in asthmatics treated with inhaled corticosteroids. Human Molecular Genetics. 13: 1353-9. PMID 15128701 DOI: 10.1093/hmg/ddh149  0.04
2019 Parikh V, Scala J, Patel R, Corbi C, Lo D, Bochkov YA, Kennedy JL, Kurten RC, Liggett SB, Gern JE, Koziol-White CJ. Rhinovirus C15 Induces Airway Hyperresponsiveness Via Calcium Mobilization in Airway Smooth Muscle. American Journal of Respiratory Cell and Molecular Biology. PMID 31533004 DOI: 10.1165/rcmb.2019-0004OC  0.01
2019 Woo JA, Castaño M, Goss A, Kim D, Lewandowski EM, Chen Y, Liggett SB. Differential long-term regulation of TAS2R14 by structurally distinct agonists. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. fj201802627RR. PMID 31430434 DOI: 10.1096/fj.201802627RR  0.01
2019 Kilic O, Yoon A, Shah SR, Yong HM, Ruiz-Valls A, Chang H, Panettieri RA, Liggett SB, Quiñones-Hinojosa A, An SS, Levchenko A. A microphysiological model of the bronchial airways reveals the interplay of mechanical and biochemical signals in bronchospasm. Nature Biomedical Engineering. PMID 31150010 DOI: 10.1038/s41551-019-0366-7  0.01
2019 Woo JA, Liu T, Fang CC, Cazzaro S, Kee T, LePochat P, Yrigoin K, Penn C, Zhao X, Wang X, Liggett SB, Kang DE. Activated cofilin exacerbates tau pathology by impairing tau-mediated microtubule dynamics. Communications Biology. 2: 112. PMID 30911686 DOI: 10.1038/s42003-019-0359-9  0.01
2018 Rajan S, Jagatheesan G, Petrashevskaya N, Biesiadecki BJ, Warren CM, Riddle T, Liggett SB, Wolska BM, Solaro RJ, Wieczorek DF. Tropomyosin pseudo-phosphorylation results in dilated cardiomyopathy. The Journal of Biological Chemistry. PMID 30567734 DOI: 10.1074/jbc.RA118.004879  0.01
2018 Gern JE, Lee WM, Swenson CA, Nakagome K, Lee I, Wolff M, Grindle K, Sigelman S, Liggett SB, Togias A, Evans M, Denlinger L, Gangnon R, Bochkov YA, Crisafi G. Development of a Rhinovirus Inoculum using a Reverse Genetics Approach. The Journal of Infectious Diseases. PMID 30383246 DOI: 10.1093/infdis/jiy629  0.01
2018 Kim D, Cho S, Castaño MA, Panettieri RA, Woo JA, Liggett SB. Biased TAS2R Bronchodilators Inhibit Airway Smooth Muscle Growth by Downregulating pERK1/2. American Journal of Respiratory Cell and Molecular Biology. PMID 30365340 DOI: 10.1165/rcmb.2018-0189OC  0.01
2018 Rettie AE, Liggett SB. Preface to Special Issue on 'Cytochrome P450 Variation in Pharmacogenomics'. Journal of Personalized Medicine. 8. PMID 29973520 DOI: 10.3390/jpm8030023  0.01
2018 Panettieri RA, Pera T, Liggett SB, Benovic JL, Penn RB. Pepducins as a potential treatment strategy for asthma and COPD. Current Opinion in Pharmacology. 40: 120-125. PMID 29729548 DOI: 10.1016/j.coph.2018.04.008  0.01
2018 Liggett SB. Genetic Vulnerability of GPCRs: A Call to Action. Trends in Biochemical Sciences. 43: 227-229. PMID 29605062 DOI: 10.1016/j.tibs.2018.02.006  0.01
2018 Xu H, Dorn Ii GW, Shetty A, Parihar A, Dave T, Robinson SW, Gottlieb SS, Donahue MP, Tomaselli GF, Kraus WE, Mitchell BD, Liggett SB. A Genome-Wide Association Study of Idiopathic Dilated Cardiomyopathy in African Americans. Journal of Personalized Medicine. 8. PMID 29495422 DOI: 10.3390/jpm8010011  0.01
2018 Kim D, Cho S, Woo JA, Liggett SB. A CREB-mediated increase in miRNA let-7f during prolonged β-agonist exposure: a novel mechanism of β-adrenergic receptor down-regulation in airway smooth muscle. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. fj201701278R. PMID 29455573 DOI: 10.1096/fj.201701278R  0.01
2017 An SS, Liggett SB. Taste and smell GPCRs in the lung: Evidence for a previously unrecognized widespread chemosensory system. Cellular Signalling. PMID 28167233 DOI: 10.1016/j.cellsig.2017.02.002  0.01
2017 Kim D, Woo JA, Geffken E, An SS, Liggett SB. Coupling of Airway Smooth Muscle TAS2Rs to Intracellular Signaling and Relaxation is via Gαi1,2,3. American Journal of Respiratory Cell and Molecular Biology. PMID 28145731 DOI: 10.1165/rcmb.2016-0373OC  0.01
2016 Aisenberg WH, Huang J, Zhu W, Rajkumar P, Cruz R, Santhanam L, Natarajan N, Yong HM, De Santiago B, Oh JJ, Yoon AR, Panettieri RA, Homann O, Sullivan JK, Liggett SB, et al. Defining an olfactory receptor function in airway smooth muscle cells. Scientific Reports. 6: 38231. PMID 27905542 DOI: 10.1038/srep38231  0.01
2016 Koziol-White CJ, Yoo EJ, Cao G, Zhang J, Papanikolaou E, Pushkarsky I, Andrews A, Himes BE, Damoiseaux RD, Liggett SB, Di Carlo D, Kurten RC, Panettieri RA. Inhibition of Phosphoinositide 3-Kinase (PI3K) promotes dilation of human small airways in a Rho kinase-dependent manner. British Journal of Pharmacology. PMID 27352269 DOI: 10.1111/bph.13542  0.01
2016 Kim D, Pauer SH, Yong HM, An SS, Liggett SB. β2-adrenergic Receptors Chaperone Trapped Bitter Taste Receptor 14 to the Cell Surface as a Heterodimer and Exert Unidirectional Desensitization of Taste Receptor Function. The Journal of Biological Chemistry. PMID 27342779 DOI: 10.1074/jbc.M116.722736  0.01
2015 Bridges TM, Scheraga RG, Tulapurkar ME, Suffredini D, Liggett SB, Ramarathnam A, Potla R, Singh IS, Hasday JD. Polymorphisms in human heat shock factor-1 and analysis of potential biological consequences. Cell Stress & Chaperones. 20: 47-59. PMID 25023647 DOI: 10.1007/s12192-014-0524-5  0.01
2014 Taylor MR, Sun AY, Davis G, Fiuzat M, Liggett SB, Bristow MR. Race, common genetic variation, and therapeutic response disparities in heart failure. Jacc. Heart Failure. 2: 561-72. PMID 25443111 DOI: 10.1016/j.jchf.2014.06.010  0.01
2014 Liggett SB. Bitter taste receptors in the wrong place: novel airway smooth muscle targets for treating asthma. Transactions of the American Clinical and Climatological Association. 125: 64-74; discussion 74. PMID 25125719  0.01
2014 Liggett SB, Bochkov YA, Pappas T, Lemanske RF, Gern JE, Sengamalay N, Zhao X, Su Q, Fraser CM, Palmenberg AC. Genome sequences of rhinovirus C isolates from wisconsin pediatric respiratory studies. Genome Announcements. 2. PMID 24675858 DOI: 10.1128/genomeA.00203-14  0.01
2014 Liggett SB, Bochkov YA, Pappas T, Lemanske RF, Gern JE, Sengamalay N, Zhao X, Su Q, Fraser CM, Palmenberg AC. Genome sequences of rhinovirus B isolates from wisconsin pediatric respiratory studies. Genome Announcements. 2. PMID 24675857 DOI: 10.1128/genomeA.00202-14  0.01
2014 Liggett SB, Bochkov YA, Pappas T, Lemanske RF, Gern JE, Sengamalay N, Zhao X, Su Q, Fraser CM, Palmenberg AC. Genome sequences of rhinovirus a isolates from wisconsin pediatric respiratory studies. Genome Announcements. 2. PMID 24675855 DOI: 10.1128/genomeA.00200-14  0.01
2013 Liggett SB. Bitter taste receptors on airway smooth muscle as targets for novel bronchodilators. Expert Opinion On Therapeutic Targets. 17: 721-31. PMID 23577615 DOI: 10.1517/14728222.2013.782395  0.01
2011 Nagele P, Liggett SB. Genetic variation, β-blockers, and perioperative myocardial infarction. Anesthesiology. 115: 1316-27. PMID 21918425 DOI: 10.1097/ALN.0b013e3182315eb2  0.01
2011 Liggett SB. Phosphorylation barcoding as a mechanism of directing GPCR signaling. Science Signaling. 4: pe36. PMID 21868354 DOI: 10.1126/scisignal.2002331  0.01
2011 Deshpande DA, Robinett KS, Wang WC, Sham JS, An SS, Liggett SB. Bronchodilator activity of bitter tastants in human tissue. Nature Medicine. 17: 776-8. PMID 21738150 DOI: 10.1038/nm0711-776b  0.01
2011 Trian T, Burgess JK, Niimi K, Moir LM, Ge Q, Berger P, Liggett SB, Black JL, Oliver BG. β2-Agonist induced cAMP is decreased in asthmatic airway smooth muscle due to increased PDE4D. Plos One. 6: e20000. PMID 21611147 DOI: 10.1371/journal.pone.0020000  0.01
2011 Bochkov YA, Palmenberg AC, Lee WM, Rathe JA, Amineva SP, Sun X, Pasic TR, Jarjour NN, Liggett SB, Gern JE. Molecular modeling, organ culture and reverse genetics for a newly identified human rhinovirus C. Nature Medicine. 17: 627-32. PMID 21483405 DOI: 10.1038/nm.2358  0.01
2011 Wang WC, Juan AH, Panebra A, Liggett SB. MicroRNA let-7 establishes expression of beta2-adrenergic receptors and dynamically down-regulates agonist-promoted down-regulation. Proceedings of the National Academy of Sciences of the United States of America. 108: 6246-51. PMID 21447718 DOI: 10.1073/pnas.1101439108  0.01
2011 Wang WC, Schillinger RM, Malone MM, Liggett SB. Paradoxical attenuation of β2-AR function in airway smooth muscle by Gi-mediated counterregulation in transgenic mice overexpressing type 5 adenylyl cyclase. American Journal of Physiology. Lung Cellular and Molecular Physiology. 300: L472-8. PMID 21131397 DOI: 10.1152/ajplung.00273.2010  0.01
2010 Jagatheesan G, Rajan S, Ahmed RP, Petrashevskaya N, Boivin G, Arteaga GM, Tae HJ, Liggett SB, Solaro RJ, Wieczorek DF. Striated muscle tropomyosin isoforms differentially regulate cardiac performance and myofilament calcium sensitivity. Journal of Muscle Research and Cell Motility. 31: 227-39. PMID 20803058 DOI: 10.1007/s10974-010-9228-3  0.01
2010 Palmenberg AC, Rathe JA, Liggett SB. Analysis of the complete genome sequences of human rhinovirus. The Journal of Allergy and Clinical Immunology. 125: 1190-9; quiz 1200-1. PMID 20471068 DOI: 10.1016/j.jaci.2010.04.010  0.01
2010 Liggett SB. Pharmacogenomics of beta1-adrenergic receptor polymorphisms in heart failure. Heart Failure Clinics. 6: 27-33. PMID 19945058 DOI: 10.1016/j.hfc.2009.08.011  0.01
2010 Rathe JA, Liu X, Tallon LJ, Gern JE, Liggett SB. Full-genome sequence and analysis of a novel human rhinovirus strain within a divergent HRV-A clade. Archives of Virology. 155: 83-7. PMID 19936613 DOI: 10.1007/s00705-009-0549-8  0.01
2009 Liggett SB. alpha2A-adrenergic receptors in the genetics, pathogenesis, and treatment of type 2 diabetes. Science Translational Medicine. 1: 12ps15. PMID 20371458 DOI: 10.1126/scitranslmed.3000606  0.01
2009 Wang WC, Mihlbachler KA, Brunnett AC, Liggett SB. Targeted transgenesis reveals discrete attenuator functions of GRK and PKA in airway beta2-adrenergic receptor physiologic signaling. Proceedings of the National Academy of Sciences of the United States of America. 106: 15007-12. PMID 19706446 DOI: 10.1073/pnas.0906034106  0.01
2009 Palmenberg AC, Spiro D, Kuzmickas R, Wang S, Djikeng A, Rathe JA, Fraser-Liggett CM, Liggett SB. Sequencing and analyses of all known human rhinovirus genomes reveal structure and evolution. Science (New York, N.Y.). 324: 55-9. PMID 19213880 DOI: 10.1126/science.1165557  0.01
2008 Kardia SL, Kelly RJ, Keddache MA, Aronow BJ, Grabowski GA, Hahn HS, Case KL, Wagoner LE, Dorn GW, Liggett SB. Multiple interactions between the alpha 2C- and beta1-adrenergic receptors influence heart failure survival. Bmc Medical Genetics. 9: 93. PMID 18947427 DOI: 10.1186/1471-2350-9-93  0.01
2008 Einstein R, Jordan H, Zhou W, Brenner M, Moses EG, Liggett SB. Alternative splicing of the G protein-coupled receptor superfamily in human airway smooth muscle diversifies the complement of receptors. Proceedings of the National Academy of Sciences of the United States of America. 105: 5230-5. PMID 18362331 DOI: 10.1073/pnas.0801319105  0.01
2007 Petrashevskaya N, Liggett SB. Tight control of adrenal medulla catecholamine release by alpha 2C-adrenergic receptors influences susceptibility to heart failure. Cardiovascular Research. 75: 631-3. PMID 17643402 DOI: 10.1016/j.cardiores.2007.07.005  0.01
2007 Rajan S, Ahmed RP, Jagatheesan G, Petrashevskaya N, Boivin GP, Urboniene D, Arteaga GM, Wolska BM, Solaro RJ, Liggett SB, Wieczorek DF. Dilated cardiomyopathy mutant tropomyosin mice develop cardiac dysfunction with significantly decreased fractional shortening and myofilament calcium sensitivity. Circulation Research. 101: 205-14. PMID 17556658 DOI: 10.1161/CIRCRESAHA.107.148379  0.01
2007 Liggett SB. Long-distance affair with adrenal GRK2 hangs up heart failure. Nature Medicine. 13: 246-8. PMID 17342115 DOI: 10.1038/nm0307-246  0.01
2006 Liggett SB. Beta2-adrenergic receptor polymorphisms and sudden cardiac death: a signal to follow. Circulation. 113: 1818-20. PMID 16618829 DOI: 10.1161/CIRCULATIONAHA.105.618967  0.01
2006 Liggett SB. Cardiac 7-transmembrane-spanning domain receptor portfolios: diversify, diversify, diversify. The Journal of Clinical Investigation. 116: 875-7. PMID 16585959 DOI: 10.1172/JCI28234  0.01
2005 McGraw DW, Liggett SB. Molecular mechanisms of beta2-adrenergic receptor function and regulation. Proceedings of the American Thoracic Society. 2: 292-6; discussion 31. PMID 16267351 DOI: 10.1513/pats.200504-027SR  0.01
2005 Liggett SB. Lymphocyte GRK levels as biomarkers in heart failure. European Heart Journal. 26: 1695-6. PMID 16055498 DOI: 10.1093/eurheartj/ehi355  0.01
2004 Liggett SB. Polymorphisms of beta-adrenergic receptors in heart failure. The American Journal of Medicine. 117: 525-7. PMID 15464712 DOI: 10.1016/j.amjmed.2004.07.039  0.01
2004 Liggett SB. Genetically modified mouse models for pharmacogenomic research. Nature Reviews. Genetics. 5: 657-63. PMID 15372087 DOI: 10.1038/nrg1429  0.01
2004 Liggett SB. The two-timing thyroid. Nature Medicine. 10: 582-3. PMID 15170201 DOI: 10.1038/nm0604-582  0.01
2003 Liggett SB. Polymorphisms of adrenergic receptors: variations on a theme. Assay and Drug Development Technologies. 1: 317-26. PMID 15090197 DOI: 10.1089/15406580360545134  0.01
2002 Liggett SB. Update on current concepts of the molecular basis of beta2-adrenergic receptor signaling. The Journal of Allergy and Clinical Immunology. 110: S223-7. PMID 12464928  0.01
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