Jeffery D. Molkentin - Publications

University of Cincinnati, Cincinnati, OH 
Molecular Biology

203 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2018 Galluzzi L, Vitale I, Aaronson SA, Abrams JM, Adam D, Agostinis P, Alnemri ES, Altucci L, Amelio I, Andrews DW, Annicchiarico-Petruzzelli M, Antonov AV, Arama E, Baehrecke EH, Barlev NA, ... ... Molkentin JD, et al. Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018. Cell Death and Differentiation. PMID 29362479 DOI: 10.1038/S41418-017-0012-4  0.8
2017 Eschenhagen T, Bolli R, Braun T, Field LJ, Fleischmann BK, Frisén J, Giacca M, Hare JM, Houser SR, Lee RT, Marbán E, Martin JF, Molkentin JD, Murry CE, Riley PR, et al. Cardiomyocyte Regeneration: A Consensus Statement. Circulation. PMID 28684531 DOI: 10.1161/Circulationaha.117.029343  0.56
2017 Luongo TS, Lambert JP, Gross P, Nwokedi M, Lombardi AA, Shanmughapriya S, Carpenter AC, Kolmetzky D, Gao E, van Berlo JH, Tsai EJ, Molkentin JD, Chen X, Madesh M, Houser SR, et al. The mitochondrial Na(+)/Ca(2+) exchanger is essential for Ca(2+) homeostasis and viability. Nature. PMID 28445457 DOI: 10.1038/Nature22082  0.8
2016 Vanhoutte D, Schips TG, Kwong JQ, Davis J, Tjondrokoesoemo A, Brody MJ, Sargent MA, Kanisicak O, Yi H, Gao QQ, Rabinowitz JE, Volk T, McNally EM, Molkentin JD. Thrombospondin expression in myofibers stabilizes muscle membranes. Elife. 5. PMID 27669143 DOI: 10.7554/Elife.17589  0.84
2016 Wallner M, Duran JM, Mohsin S, Troupes CD, Vanhoutte D, Borghetti G, Vagnozzi RJ, Gross P, Yu D, Trappanese DM, Kubo H, Toib A, Sharp TE, Harper SC, Volkert MA, ... ... Molkentin JD, et al. Acute Catecholamine Exposure Causes Reversible Myocyte Injury Without Cardiac Regeneration. Circulation Research. PMID 27461939 DOI: 10.1161/Circresaha.116.308687  0.84
2016 Kanisicak O, Khalil H, Ivey MJ, Karch J, Maliken BD, Correll RN, Brody MJ, J Lin SC, Aronow BJ, Tallquist MD, Molkentin JD. Genetic lineage tracing defines myofibroblast origin and function in the injured heart. Nature Communications. 7: 12260. PMID 27447449 DOI: 10.1038/Ncomms12260  0.84
2016 Liu R, van Berlo JH, York AJ, Maillet M, Vagnozzi RJ, Molkentin JD. DUSP8 Regulates Cardiac Ventricular Remodeling by Altering ERK1/2 Signaling. Circulation Research. PMID 27225478 DOI: 10.1161/Circresaha.115.308238  0.84
2016 Lamar KM, Bogdanovich S, Gardner BB, Gao QQ, Miller T, Earley JU, Hadhazy M, Vo AH, Wren L, Molkentin JD, McNally EM. Overexpression of Latent TGFβ Binding Protein 4 in Muscle Ameliorates Muscular Dystrophy through Myostatin and TGFβ. Plos Genetics. 12: e1006019. PMID 27148972 DOI: 10.1371/Journal.Pgen.1006019  0.84
2016 Tjondrokoesoemo A, Schips TG, Sargent MA, Vanhoutte D, Kanisicak O, Prasad V, Lin SJ, Maillet M, Molkentin JD. Cathepsin S contributes to the pathogenesis of muscular dystrophy in mice. The Journal of Biological Chemistry. PMID 26966179 DOI: 10.1074/Jbc.M116.719054  0.84
2015 Davis J, Salomonis N, Ghearing N, Lin SC, Kwong JQ, Mohan A, Swanson MS, Molkentin JD. MBNL1-mediated regulation of differentiation RNAs promotes myofibroblast transformation and the fibrotic response. Nature Communications. 6: 10084. PMID 26670661 DOI: 10.1038/Ncomms10084  0.84
2015 Li L, Chen Y, Li J, Yin H, Guo X, Doan J, Molkentin JD, Liu Q. TAK1 Regulates Myocardial Response to Pathological Stress via NFAT, NFκB, and Bnip3 Pathways. Scientific Reports. 5: 16626. PMID 26564789 DOI: 10.1038/Srep16626  0.84
2015 Brody MJ, Schips TG, Vanhoutte D, Kanisicak O, Karch J, Maliken BD, Blair NS, Sargent MA, Prasad V, Molkentin JD. Dissection of thrombospondin-4 domains involved in intracellular adaptive ER Stress responsive signaling. Molecular and Cellular Biology. PMID 26459760 DOI: 10.1128/Mcb.00607-15  0.84
2015 Pfluger PT, Kabra DG, Aichler M, Schriever SC, Pfuhlmann K, García VC, Lehti M, Weber J, Kutschke M, Rozman J, Elrod JW, Hevener AL, Feuchtinger A, Hrabě de Angelis M, Walch A, ... ... Molkentin JD, et al. Calcineurin Links Mitochondrial Elongation with Energy Metabolism. Cell Metabolism. PMID 26411342 DOI: 10.1016/J.Cmet.2015.08.022  0.8
2015 Correll RN, Goonasekera SA, van Berlo JH, Burr AR, Accornero F, Zhang H, Makarewich CA, York AJ, Sargent MA, Chen X, Houser SR, Molkentin JD. STIM1 elevation in the heart results in aberrant Ca(2+) handling and cardiomyopathy. Journal of Molecular and Cellular Cardiology. PMID 26241845 DOI: 10.1016/J.Yjmcc.2015.07.032  0.84
2015 Kwong JQ, Lu X, Correll RN, Schwanekamp JA, Vagnozzi RJ, Sargent MA, York AJ, Zhang J, Bers DM, Molkentin JD. The Mitochondrial Calcium Uniporter Selectively Matches Metabolic Output to Acute Contractile Stress in the Heart. Cell Reports. PMID 26119742 DOI: 10.1016/J.Celrep.2015.06.002  0.84
2015 Shojaee S, Caeser R, Buchner M, Park E, Swaminathan S, Hurtz C, Geng H, Chan LN, Klemm L, Hofmann WK, Qiu YH, Zhang N, Coombes KR, Paietta E, Molkentin J, et al. Erk Negative Feedback Control Enables Pre-B Cell Transformation and Represents a Therapeutic Target in Acute Lymphoblastic Leukemia. Cancer Cell. 28: 114-28. PMID 26073130 DOI: 10.1016/J.Ccell.2015.05.008  0.84
2015 Mukherjee R, Mareninova OA, Odinokova IV, Huang W, Murphy J, Chvanov M, Javed MA, Wen L, Booth DM, Cane MC, Awais M, Gavillet B, Pruss RM, Schaller S, Molkentin JD, et al. Mechanism of mitochondrial permeability transition pore induction and damage in the pancreas: inhibition prevents acute pancreatitis by protecting production of ATP. Gut. PMID 26071131 DOI: 10.1136/Gutjnl-2014-308553  0.84
2015 Karch J, Kanisicak O, Brody MJ, Sargent MA, Michael DM, Molkentin JD. Necroptosis Interfaces with MOMP and the MPTP in Mediating Cell Death. Plos One. 10: e0130520. PMID 26061004 DOI: 10.1371/Journal.Pone.0130520  0.84
2015 Accornero F, van Berlo JH, Correll RN, Elrod JW, Sargent MA, York A, Rabinowitz JE, Leask A, Molkentin JD. Genetic Analysis of Connective Tissue Growth Factor as an Effector of Transforming Growth Factor β Signaling and Cardiac Remodeling. Molecular and Cellular Biology. 35: 2154-64. PMID 25870108 DOI: 10.1128/Mcb.00199-15  0.84
2015 Mázala DA, Pratt SJ, Chen D, Molkentin JD, Lovering RM, Chin ER. SERCA1 overexpression minimizes skeletal muscle damage in dystrophic mouse models. American Journal of Physiology. Cell Physiology. 308: C699-709. PMID 25652448 DOI: 10.1152/Ajpcell.00341.2014  0.84
2015 Kwong JQ, Molkentin JD. Physiological and pathological roles of the mitochondrial permeability transition pore in the heart. Cell Metabolism. 21: 206-14. PMID 25651175 DOI: 10.1016/J.Cmet.2014.12.001  0.84
2015 Liu R, Correll RN, Davis J, Vagnozzi RJ, York AJ, Sargent MA, Nairn AC, Molkentin JD. Cardiac-specific deletion of protein phosphatase 1β promotes increased myofilament protein phosphorylation and contractile alterations Journal of Molecular and Cellular Cardiology. 87: 204-213. DOI: 10.1016/j.yjmcc.2015.08.018  0.84
2014 Ceco E, Bogdanovich S, Gardner B, Miller T, DeJesus A, Earley JU, Hadhazy M, Smith LR, Barton ER, Molkentin JD, McNally EM. Targeting latent TGFβ release in muscular dystrophy. Science Translational Medicine. 6: 259ra144. PMID 25338755 DOI: 10.1126/Scitranslmed.3010018  0.84
2014 Lauriol J, Keith K, Jaffré F, Couvillon A, Saci A, Goonasekera SA, McCarthy JR, Kessinger CW, Wang J, Ke Q, Kang PM, Molkentin JD, Carpenter C, Kontaridis MI. RhoA signaling in cardiomyocytes protects against stress-induced heart failure but facilitates cardiac fibrosis. Science Signaling. 7: ra100. PMID 25336613 DOI: 10.1126/Scisignal.2005262  0.84
2014 Khatlani T, Pradhan S, Da Q, Gushiken FC, Bergeron AL, Langlois KW, Molkentin JD, Rumbaut RE, Vijayan KV. The β isoform of the catalytic subunit of protein phosphatase 2B restrains platelet function by suppressing outside-in αII b β3 integrin signaling. Journal of Thrombosis and Haemostasis : Jth. 12: 2089-101. PMID 25330904 DOI: 10.1111/jth.12761  0.84
2014 Li L, Chen Y, Doan J, Murray J, Molkentin JD, Liu Q. Transforming growth factor β-activated kinase 1 signaling pathway critically regulates myocardial survival and remodeling. Circulation. 130: 2162-72. PMID 25278099 DOI: 10.1161/Circulationaha.114.011195  0.84
2014 Gupta MK, Gulick J, Liu R, Wang X, Molkentin JD, Robbins J. Sumo E2 enzyme UBC9 is required for efficient protein quality control in cardiomyocytes. Circulation Research. 115: 721-9. PMID 25097219 DOI: 10.1161/Circresaha.115.304760  0.84
2014 Makarewich CA, Zhang H, Davis J, Correll RN, Trappanese DM, Hoffman NE, Troupes CD, Berretta RM, Kubo H, Madesh M, Chen X, Gao E, Molkentin JD, Houser SR. Transient receptor potential channels contribute to pathological structural and functional remodeling after myocardial infarction. Circulation Research. 115: 567-80. PMID 25047165 DOI: 10.1161/Circresaha.115.303831  0.84
2014 Tane S, Kubota M, Okayama H, Ikenishi A, Yoshitome S, Iwamoto N, Satoh Y, Kusakabe A, Ogawa S, Kanai A, Molkentin JD, Nakamura K, Ohbayashi T, Takeuchi T. Repression of cyclin D1 expression is necessary for the maintenance of cell cycle exit in adult mammalian cardiomyocytes. The Journal of Biological Chemistry. 289: 18033-44. PMID 24821722 DOI: 10.1074/Jbc.M113.541953  0.84
2014 van Berlo JH, Kanisicak O, Maillet M, Vagnozzi RJ, Karch J, Lin SC, Middleton RC, Marbán E, Molkentin JD. c-kit+ cells minimally contribute cardiomyocytes to the heart. Nature. 509: 337-41. PMID 24805242 DOI: 10.1038/Nature13309  0.84
2014 Gutiérrez-Aguilar M, Douglas DL, Gibson AK, Domeier TL, Molkentin JD, Baines CP. Genetic manipulation of the cardiac mitochondrial phosphate carrier does not affect permeability transition. Journal of Molecular and Cellular Cardiology. 72: 316-25. PMID 24768964 DOI: 10.1016/J.Yjmcc.2014.04.008  0.84
2014 Kwong JQ, Davis J, Baines CP, Sargent MA, Karch J, Wang X, Huang T, Molkentin JD. Genetic deletion of the mitochondrial phosphate carrier desensitizes the mitochondrial permeability transition pore and causes cardiomyopathy Cell Death and Differentiation. 21: 1209-1217. PMID 24658400 DOI: 10.1038/Cdd.2014.36  0.84
2014 Taddeo EP, Laker RC, Breen DS, Akhtar YN, Kenwood BM, Liao JA, Zhang M, Fazakerley DJ, Tomsig JL, Harris TE, Keller SR, Chow JD, Lynch KR, Chokki M, Molkentin JD, et al. Opening of the mitochondrial permeability transition pore links mitochondrial dysfunction to insulin resistance in skeletal muscle. Molecular Metabolism. 3: 124-34. PMID 24634818 DOI: 10.1016/J.Molmet.2013.11.003  0.84
2014 Goonasekera SA, Davis J, Kwong JQ, Accornero F, Wei-LaPierre L, Sargent MA, Dirksen RT, Molkentin JD. Enhanced Ca²⁺ influx from STIM1-Orai1 induces muscle pathology in mouse models of muscular dystrophy. Human Molecular Genetics. 23: 3706-15. PMID 24556214 DOI: 10.1093/Hmg/Ddu079  0.84
2014 Molkentin JD, Houser SR. Response to Torella et al. Circulation Research. 114: e27. PMID 24526680 DOI: 10.1161/Circresaha.114.303361  0.84
2014 Correll RN, Eder P, Burr AR, Despa S, Davis J, Bers DM, Molkentin JD. Overexpression of the Na+/K+ ATPase α2 but not α1 isoform attenuates pathological cardiac hypertrophy and remodeling. Circulation Research. 114: 249-56. PMID 24218169 DOI: 10.1161/Circresaha.114.302293  0.84
2013 Davis J, Kwong JQ, Kitsis RN, Molkentin JD. Apoptosis repressor with a CARD domain (ARC) restrains Bax-mediated pathogenesis in dystrophic skeletal muscle. Plos One. 8: e82053. PMID 24312627 DOI: 10.1371/Journal.Pone.0082053  0.84
2013 Braitsch CM, Kanisicak O, van Berlo JH, Molkentin JD, Yutzey KE. Differential expression of embryonic epicardial progenitor markers and localization of cardiac fibrosis in adult ischemic injury and hypertensive heart disease. Journal of Molecular and Cellular Cardiology. 65: 108-19. PMID 24140724 DOI: 10.1016/J.Yjmcc.2013.10.005  0.84
2013 Molkentin JD, Houser SR. Are resident c-Kit+ cardiac stem cells really all that are needed to mend a broken heart? Circulation Research. 113: 1037-9. PMID 24115067 DOI: 10.1161/Circresaha.113.302564  0.84
2013 Karch J, Kwong JQ, Burr AR, Sargent MA, Elrod JW, Peixoto PM, Martinez-Caballero S, Osinska H, Cheng EH, Robbins J, Kinnally KW, Molkentin JD. Bax and Bak function as the outer membrane component of the mitochondrial permeability pore in regulating necrotic cell death in mice. Elife. 2: e00772. PMID 23991283 DOI: 10.7554/Elife.00772  0.8
2013 Correll RN, Molkentin JD. CaMKII does it again: even the mitochondria cannot escape its influence. Circulation Research. 112: 1208-11. PMID 23620234 DOI: 10.1161/Circresaha.113.301263  0.84
2013 Elrod JW, Molkentin JD. Physiologic functions of cyclophilin D and the mitochondrial permeability transition pore. Circulation Journal : Official Journal of the Japanese Circulation Society. 77: 1111-22. PMID 23538482 DOI: 10.1253/Circj.Cj-13-0321  0.8
2013 Nicholson CK, Lambert JP, Molkentin JD, Sadoshima J, Calvert JW. Thioredoxin 1 is essential for sodium sulfide-mediated cardioprotection in the setting of heart failure. Arteriosclerosis, Thrombosis, and Vascular Biology. 33: 744-51. PMID 23349187 DOI: 10.1161/Atvbaha.112.300484  0.84
2013 Suk HY, Zhou C, Yang TT, Zhu H, Yu RY, Olabisi O, Yang X, Brancho D, Kim JY, Scherer PE, Frank PG, Lisanti MP, Calvert JW, Lefer DJ, Molkentin JD, et al. Ablation of calcineurin Aβ reveals hyperlipidemia and signaling cross-talks with phosphodiesterases. The Journal of Biological Chemistry. 288: 3477-88. PMID 23258544 DOI: 10.1074/Jbc.M112.419150  0.84
2013 Auger-Messier M, Accornero F, Goonasekera SA, Bueno OF, Lorenz JN, van Berlo JH, Willette RN, Molkentin JD. Unrestrained p38 MAPK activation in Dusp1/4 double-null mice induces cardiomyopathy. Circulation Research. 112: 48-56. PMID 22993413 DOI: 10.1161/Circresaha.112.272963  0.84
2013 Karch J, Kwong JQ, Burr AR, Sargent MA, Elrod JW, Peixoto PM, Martinez-Caballero S, Osinska H, Cheng EH, Robbins J, Kinnally KW, Molkentin JD. Author response: Bax and Bak function as the outer membrane component of the mitochondrial permeability pore in regulating necrotic cell death in mice Elife. DOI: 10.7554/Elife.00772.020  0.8
2013 Auger-Messier M, Accornero F, Goonasekera SA, Bueno OF, Lorenz JN, Berlo Jv, Willette RN, Molkentin JD. Erratum: Unrestrained p38 MAPK activation in Dusp1/4 double-null mice induces cardiomyopathy (Circulation Research (2013) 112 (48-56) DOI: 10.1161/CIRCRESAHA.112.272963) Circulation Research. 112. DOI: 10.1161/Res.0B013E318286C253  0.72
2012 Drawnel FM, Wachten D, Molkentin JD, Maillet M, Aronsen JM, Swift F, Sjaastad I, Liu N, Catalucci D, Mikoshiba K, Hisatsune C, Okkenhaug H, Andrews SR, Bootman MD, Roderick HL. Mutual antagonism between IP(3)RII and miRNA-133a regulates calcium signals and cardiac hypertrophy. The Journal of Cell Biology. 199: 783-98. PMID 23166348 DOI: 10.1085/Jgp1411Oia1  0.84
2012 Schulz EM, Correll RN, Sheikh HN, Lofrano-Alves MS, Engel PL, Newman G, Schultz JEJ, Molkentin JD, Wolska BM, Solaro RJ, Wieczorek DF. Tropomyosin dephosphorylation results in compensated cardiac hypertrophy Journal of Biological Chemistry. 287: 44478-44489. PMID 23148217 DOI: 10.1074/Jbc.M112.402040  0.84
2012 Davis J, Burr AR, Davis GF, Birnbaumer L, Molkentin JD. A TRPC6-dependent pathway for myofibroblast transdifferentiation and wound healing in vivo. Developmental Cell. 23: 705-15. PMID 23022034 DOI: 10.1016/J.Devcel.2012.08.017  0.84
2012 Gao H, Wang F, Wang W, Makarewich CA, Zhang H, Kubo H, Berretta RM, Barr LA, Molkentin JD, Houser SR. Ca(2+) influx through L-type Ca(2+) channels and transient receptor potential channels activates pathological hypertrophy signaling. Journal of Molecular and Cellular Cardiology. 53: 657-67. PMID 22921230 DOI: 10.1016/J.Yjmcc.2012.08.005  0.84
2012 Lynch JM, Maillet M, Vanhoutte D, Schloemer A, Sargent MA, Blair NS, Lynch KA, Okada T, Aronow BJ, Osinska H, Prywes R, Lorenz JN, Mori K, Lawler J, Robbins J, ... Molkentin JD, et al. A thrombospondin-dependent pathway for a protective ER stress response. Cell. 149: 1257-68. PMID 22682248 DOI: 10.1016/J.Cell.2012.03.050  0.84
2012 Houser SR, Margulies KB, Murphy AM, Spinale FG, Francis GS, Prabhu SD, Rockman HA, Kass DA, Molkentin JD, Sussman MA, Koch WJ, Koch W. Animal models of heart failure: a scientific statement from the American Heart Association. Circulation Research. 111: 131-50. PMID 22595296 DOI: 10.1161/Res.0B013E3182582523  0.84
2012 Makarewich CA, Correll RN, Gao H, Zhang H, Yang B, Berretta RM, Rizzo V, Molkentin JD, Houser SR. A caveolae-targeted L-type Ca²+ channel antagonist inhibits hypertrophic signaling without reducing cardiac contractility. Circulation Research. 110: 669-74. PMID 22302787 DOI: 10.1161/Circresaha.111.264028  0.84
2012 Goonasekera SA, Hammer K, Auger-Messier M, Bodi I, Chen X, Zhang H, Reiken S, Elrod JW, Correll RN, York AJ, Sargent MA, Hofmann F, Moosmang S, Marks AR, Houser SR, ... ... Molkentin JD, et al. Decreased cardiac L-type Ca²⁺ channel activity induces hypertrophy and heart failure in mice. The Journal of Clinical Investigation. 122: 280-90. PMID 22133878 DOI: 10.1172/Jci58227  0.84
2011 Ladage D, Tilemann L, Ishikawa K, Correll RN, Kawase Y, Houser SR, Molkentin JD, Hajjar RJ. Inhibition of PKCα/β with ruboxistaurin antagonizes heart failure in pigs after myocardial infarction injury. Circulation Research. 109: 1396-400. PMID 21998327 DOI: 10.1161/Circresaha.111.255687  0.84
2011 Hom JR, Quintanilla RA, Hoffman DL, de Mesy Bentley KL, Molkentin JD, Sheu SS, Porter GA. The permeability transition pore controls cardiac mitochondrial maturation and myocyte differentiation. Developmental Cell. 21: 469-78. PMID 21920313 DOI: 10.1016/J.Devcel.2011.08.008  0.84
2011 Xiang SY, Vanhoutte D, Del Re DP, Purcell NH, Ling H, Banerjee I, Bossuyt J, Lang RA, Zheng Y, Matkovich SJ, Miyamoto S, Molkentin JD, Dorn GW, Brown JH. RhoA protects the mouse heart against ischemia/reperfusion injury. The Journal of Clinical Investigation. 121: 3269-76. PMID 21747165 DOI: 10.1172/Jci44371  0.84
2011 van Berlo JH, Elrod JW, Aronow BJ, Pu WT, Molkentin JD. Serine 105 phosphorylation of transcription factor GATA4 is necessary for stress-induced cardiac hypertrophy in vivo. Proceedings of the National Academy of Sciences of the United States of America. 108: 12331-6. PMID 21746915 DOI: 10.1073/Pnas.1104499108  0.8
2011 Qian L, Wythe JD, Liu J, Cartry J, Vogler G, Mohapatra B, Otway RT, Huang Y, King IN, Maillet M, Zheng Y, Crawley T, Taghli-Lamallem O, Semsarian C, Dunwoodie S, ... ... Molkentin JD, et al. Tinman/Nkx2-5 acts via miR-1 and upstream of Cdc42 to regulate heart function across species. The Journal of Cell Biology. 193: 1181-96. PMID 21690310 DOI: 10.1083/Jcb.201006114  0.84
2011 Accornero F, Van Berlo JH, Benard MJ, Lorenz JN, Carmeliet P, Molkentin JD. Placental growth factor regulates cardiac adaptation and hypertrophy through a paracrine mechanism Circulation Research. 109: 272-280. PMID 21636802 DOI: 10.1161/Circresaha.111.240820  0.84
2011 Stefater JA, Lewkowich I, Rao S, Mariggi G, Carpenter AC, Burr AR, Fan J, Ajima R, Molkentin JD, Williams BO, Wills-Karp M, Pollard JW, Yamaguchi T, Ferrara N, Gerhardt H, et al. Regulation of angiogenesis by a non-canonical Wnt-Flt1 pathway in myeloid cells. Nature. 474: 511-5. PMID 21623369 DOI: 10.1038/Nature10085  0.84
2011 Sadayappan S, Gulick J, Osinska H, Barefield D, Cuello F, Avkiran M, Lasko VM, Lorenz JN, Maillet M, Martin JL, Brown JH, Bers DM, Molkentin JD, James J, Robbins J. A critical function for Ser-282 in cardiac Myosin binding protein-C phosphorylation and cardiac function. Circulation Research. 109: 141-50. PMID 21597010 DOI: 10.1161/Circresaha.111.242560  0.84
2011 Meissner M, Weissgerber P, Londoño JE, Prenen J, Link S, Ruppenthal S, Molkentin JD, Lipp P, Nilius B, Freichel M, Flockerzi V. Moderate calcium channel dysfunction in adult mice with inducible cardiomyocyte-specific excision of the cacnb2 gene. The Journal of Biological Chemistry. 286: 15875-82. PMID 21357697 DOI: 10.1074/Jbc.M111.227819  0.84
2011 Goonasekera SA, Lam CK, Millay DP, Sargent MA, Hajjar RJ, Kranias EG, Molkentin JD. Mitigation of muscular dystrophy in mice by SERCA overexpression in skeletal muscle. The Journal of Clinical Investigation. 121: 1044-52. PMID 21285509 DOI: 10.1172/Jci43844  0.84
2011 Sengupta A, Molkentin JD, Paik JH, DePinho RA, Yutzey KE. FoxO transcription factors promote cardiomyocyte survival upon induction of oxidative stress. The Journal of Biological Chemistry. 286: 7468-78. PMID 21159781 DOI: 10.1074/Jbc.M110.179242  0.84
2011 Kehat I, Davis J, Tiburcy M, Accornero F, Saba-El-Leil MK, Maillet M, York AJ, Lorenz JN, Zimmermann WH, Meloche S, Molkentin JD. Extracellular signal-regulated kinases 1 and 2 regulate the balance between eccentric and concentric cardiac growth. Circulation Research. 108: 176-83. PMID 21127295 DOI: 10.1161/Circresaha.110.231514  0.84
2011 Chen X, Nakayama H, Zhang X, Ai X, Harris DM, Tang M, Zhang H, Szeto C, Stockbower K, Berretta RM, Eckhart AD, Koch WJ, Molkentin JD, Houser SR. Calcium influx through Cav1.2 is a proximal signal for pathological cardiomyocyte hypertrophy. Journal of Molecular and Cellular Cardiology. 50: 460-70. PMID 21111744 DOI: 10.1016/J.Yjmcc.2010.11.012  0.84
2011 Sugden PH, Markou T, Fuller SJ, Tham el L, Molkentin JD, Paterson HF, Clerk A. Monophosphothreonyl extracellular signal-regulated kinases 1 and 2 (ERK1/2) are formed endogenously in intact cardiac myocytes and are enzymically active. Cellular Signalling. 23: 468-77. PMID 21044683 DOI: 10.1016/J.Cellsig.2010.10.024  0.84
2011 Reddy RN, Knotts TL, Roberts BR, Molkentin JD, Price SR, Gooch JL. Calcineurin A-β is required for hypertrophy but not matrix expansion in the diabetic kidney. Journal of Cellular and Molecular Medicine. 15: 414-22. PMID 19778355 DOI: 10.1111/J.1582-4934.2009.00910.X  0.84
2011 Sugden PH, Markou T, Fuller SJ, Tham EL, Molkentin JD, Paterson HF, Clerk A. Corrigendum to "Monophosphothreonyl extracellular signal-regulated kinases 1 and 2 (ERK1/2) are formed endogenously in intact cardiac myocytes and are enzymically active" [Cell Signal 23 (2011) 468-477] Cellular Signalling. 23: 950. DOI: 10.1016/J.Cellsig.2011.01.011  0.84
2010 Elrod JW, Wong R, Mishra S, Vagnozzi RJ, Sakthievel B, Goonasekera SA, Karch J, Gabel S, Farber J, Force T, Brown JH, Murphy E, Molkentin JD. Cyclophilin D controls mitochondrial pore-dependent Ca(2+) exchange, metabolic flexibility, and propensity for heart failure in mice. The Journal of Clinical Investigation. 120: 3680-7. PMID 20890047 DOI: 10.1172/Jci43171  0.84
2010 Force T, Bonow RO, Houser SR, Solaro RJ, Hershberger RE, Adhikari B, Anderson ME, Boineau R, Byrne BJ, Cappola TP, Kalluri R, LeWinter MM, Maron MS, Molkentin JD, Ommen SR, et al. Research priorities in hypertrophic cardiomyopathy: report of a Working Group of the National Heart, Lung, and Blood Institute. Circulation. 122: 1130-3. PMID 20837938 DOI: 10.1161/Circulationaha.110.950089  0.84
2010 Sun T, Wu XS, Xu J, McNeil BD, Pang ZP, Yang W, Bai L, Qadri S, Molkentin JD, Yue DT, Wu LG. The role of calcium/calmodulin-activated calcineurin in rapid and slow endocytosis at central synapses. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 11838-47. PMID 20810903 DOI: 10.1523/Jneurosci.1481-10.2010  0.84
2010 van Berlo JH, Elrod JW, van den Hoogenhof MM, York AJ, Aronow BJ, Duncan SA, Molkentin JD. The transcription factor GATA-6 regulates pathological cardiac hypertrophy. Circulation Research. 107: 1032-40. PMID 20705924 DOI: 10.1161/Circresaha.110.220764  0.84
2010 Zhang H, Chen X, Gao E, MacDonnell SM, Wang W, Kolpakov M, Nakayama H, Zhang X, Jaleel N, Harris DM, Li Y, Tang M, Berretta R, Leri A, Kajstura J, ... ... Molkentin JD, et al. Increasing cardiac contractility after myocardial infarction exacerbates cardiac injury and pump dysfunction Circulation Research. 107: 800-809. PMID 20671241 DOI: 10.1016/J.Bpj.2008.12.1276  0.84
2010 Heineke J, Auger-Messier M, Correll RN, Xu J, Benard MJ, Yuan W, Drexler H, Parise LV, Molkentin JD. CIB1 is a regulator of pathological cardiac hypertrophy Nature Medicine. 16: 872-879. PMID 20639889 DOI: 10.1038/Nm.2181  0.84
2010 Nakayama H, Bodi I, Maillet M, DeSantiago J, Domeier TL, Mikoshiba K, Lorenz JN, Blatter LA, Bers DM, Molkentin JD. The IP3 receptor regulates cardiac hypertrophy in response to select stimuli. Circulation Research. 107: 659-66. PMID 20616315 DOI: 10.1161/Circresaha.110.220038  0.84
2010 Tang M, Zhang X, Li Y, Guan Y, Ai X, Szeto C, Nakayama H, Zhang H, Ge S, Molkentin JD, Houser SR, Chen X. Enhanced basal contractility but reduced excitation-contraction coupling efficiency and beta-adrenergic reserve of hearts with increased Cav1.2 activity. American Journal of Physiology. Heart and Circulatory Physiology. 299: H519-28. PMID 20543081 DOI: 10.1152/Ajpheart.00265.2010  0.84
2010 Kitsis RN, Molkentin JD. Apoptotic cell death "Nixed" by an ER-mitochondrial necrotic pathway. Proceedings of the National Academy of Sciences of the United States of America. 107: 9031-2. PMID 20448198 DOI: 10.1073/Pnas.1003827107  0.84
2010 Wu X, Eder P, Chang B, Molkentin JD. TRPC channels are necessary mediators of pathologic cardiac hypertrophy Proceedings of the National Academy of Sciences of the United States of America. 107: 7000-7005. PMID 20351294 DOI: 10.1073/Pnas.1001825107  0.84
2010 Rinne A, Kapur N, Molkentin JD, Pogwizd SM, Bers DM, Banach K, Blatter LA. Isoform- and tissue-specific regulation of the Ca2+-sensitive transcription factor NFAT in cardiac myocytes and heart failure American Journal of Physiology - Heart and Circulatory Physiology. 298: H2001-H2009. PMID 20304816 DOI: 10.1152/Ajpheart.01072.2009  0.84
2010 Tsika RW, Ma L, Kehat I, Schramm C, Simmer G, Morgan B, Fine DM, Hanft LM, McDonald KS, Molkentin JD, Krenz M, Yang S, Ji J. TEAD-1 overexpression in the mouse heart promotes an age-dependent heart dysfunction. The Journal of Biological Chemistry. 285: 13721-35. PMID 20194497 DOI: 10.1074/Jbc.M109.063057  0.84
2010 Navedo MF, Cheng EP, Yuan C, Votaw S, Molkentin JD, Scott JD, Santana LF. Increased coupled gating of L-type Ca2+ channels during hypertension and Timothy syndrome. Circulation Research. 106: 748-56. PMID 20110531 DOI: 10.1161/Circresaha.109.213363  0.84
2010 Quinsay MN, Lee Y, Rikka S, Sayen MR, Molkentin JD, Gottlieb RA, Gustafsson AB. Bnip3 mediates permeabilization of mitochondria and release of cytochrome c via a novel mechanism. Journal of Molecular and Cellular Cardiology. 48: 1146-56. PMID 20025887 DOI: 10.1016/J.Yjmcc.2009.12.004  0.84
2010 Heineke J, Wollert KC, Osinska H, Sargent MA, York AJ, Robbins J, Molkentin JD. Calcineurin protects the heart in a murine model of dilated cardiomyopathy. Journal of Molecular and Cellular Cardiology. 48: 1080-7. PMID 19854199 DOI: 10.1016/J.Yjmcc.2009.10.012  0.84
2010 Navedo MF, Takeda Y, Nieves-Cintrón M, Molkentin JD, Santana LF. Elevated Ca2+ sparklet activity during acute hyperglycemia and diabetes in cerebral arterial smooth muscle cells. American Journal of Physiology. Cell Physiology. 298: C211-20. PMID 19846755 DOI: 10.1152/Ajpcell.00267.2009  0.84
2009 Nakayama H, Bodi I, Correll RN, Chen X, Lorenz J, Houser SR, Robbins J, Schwartz A, Molkentin JD. alpha1G-dependent T-type Ca2+ current antagonizes cardiac hypertrophy through a NOS3-dependent mechanism in mice. The Journal of Clinical Investigation. 119: 3787-96. PMID 19920353 DOI: 10.1172/Jci39724  0.84
2009 Liu Q, Sargent MA, York AJ, Molkentin JD. ASK1 regulates cardiomyocyte death but not hypertrophy in transgenic mice Circulation Research. 105: 1110-1117. PMID 19815822 DOI: 10.1161/Circresaha.109.200741  0.84
2009 Bommireddy R, Bueno OF, Martin J, Ormsby I, Chen H, Gard C, Molkentin JD, Boivin GP, Babcock GF, Doetschman T. Calcineurin deficiency decreases inflammatory lesions in transforming growth factor beta1-deficient mice. Clinical and Experimental Immunology. 158: 317-24. PMID 19747209 DOI: 10.1111/J.1365-2249.2009.04015.X  0.84
2009 Maillet M, Lynch JM, Sanna B, York AJ, Zheng Y, Molkentin JD. Cdc42 is an antihypertrophic molecular switch in the mouse heart. The Journal of Clinical Investigation. 119: 3079-88. PMID 19741299 DOI: 10.1172/Jci37694  0.84
2009 Tkatchenko TV, Moreno-Rodriguez RA, Conway SJ, Molkentin JD, Markwald RR, Tkatchenko AV. Lack of periostin leads to suppression of Notch1 signaling and calcific aortic valve disease. Physiological Genomics. 39: 160-8. PMID 19723774 DOI: 10.1152/Physiolgenomics.00078.2009  0.84
2009 Sengupta A, Molkentin JD, Yutzey KE. FoxO transcription factors promote autophagy in cardiomyocytes. The Journal of Biological Chemistry. 284: 28319-31. PMID 19696026 DOI: 10.1074/Jbc.M109.024406  0.84
2009 MacDonnell SM, Weisser-Thomas J, Kubo H, Hanscome M, Liu Q, Jaleel N, Berretta R, Chen X, Brown JH, Sabri AK, Molkentin JD, Houser SR. CaMKII negatively regulates calcineurin-NFAT signaling in cardiac myocytes. Circulation Research. 105: 316-25. PMID 19608982 DOI: 10.1161/Circresaha.109.194035  0.84
2009 Liu Q, Chen X, Macdonnell SM, Kranias EG, Lorenz JN, Leitges M, Houser SR, Molkentin JD. Protein kinase C{alpha}, but not PKC{beta} or PKC{gamma}, regulates contractility and heart failure susceptibility: implications for ruboxistaurin as a novel therapeutic approach. Circulation Research. 105: 194-200. PMID 19556521 DOI: 10.1161/Circresaha.109.195313  0.84
2009 Ito K, Akazawa H, Tamagawa M, Furukawa K, Ogawa W, Yasuda N, Kudo Y, Liao CH, Yamamoto R, Sato T, Molkentin JD, Kasuga M, Noda T, Nakaya H, Komuro I. PDK1 coordinates survival pathways and beta-adrenergic response in the heart. Proceedings of the National Academy of Sciences of the United States of America. 106: 8689-94. PMID 19429709 DOI: 10.1073/Pnas.0900064106  0.84
2009 Wu X, Chang B, Blair NS, Sargent M, York AJ, Robbins J, Shull GE, Molkentin JD. Plasma membrane Ca2+-ATPase isoform 4 antagonizes cardiac hypertrophy in association with calcineurin inhibition in rodents. The Journal of Clinical Investigation. 119: 976-85. PMID 19287093 DOI: 10.1172/Jci36693  0.84
2009 Martin LJ, Gertz B, Pan Y, Price AC, Molkentin JD, Chang Q. The mitochondrial permeability transition pore in motor neurons: involvement in the pathobiology of ALS mice. Experimental Neurology. 218: 333-46. PMID 19272377 DOI: 10.1016/J.Expneurol.2009.02.015  0.84
2009 Carneiro LA, Travassos LH, Soares F, Tattoli I, Magalhaes JG, Bozza MT, Plotkowski MC, Sansonetti PJ, Molkentin JD, Philpott DJ, Girardin SE. Shigella induces mitochondrial dysfunction and cell death in nonmyleoid cells. Cell Host & Microbe. 5: 123-36. PMID 19218084 DOI: 10.1016/J.Chom.2008.12.011  0.84
2009 Donaldson C, Eder S, Baker C, Aronovitz MJ, Weiss AD, Hall-Porter M, Wang F, Ackerman A, Karas RH, Molkentin JD, Patten RD. Estrogen attenuates left ventricular and cardiomyocyte hypertrophy by an estrogen receptor-dependent pathway that increases calcineurin degradation. Circulation Research. 104: 265-75, 11p followin. PMID 19074476 DOI: 10.1161/Circresaha.108.190397  0.84
2009 Lorts A, Schwanekamp JA, Elrod JW, Sargent MA, Molkentin JD. Genetic manipulation of periostin expression in the heart does not affect myocyte content, cell cycle activity, or cardiac repair. Circulation Research. 104: e1-7. PMID 19038863 DOI: 10.1161/Circresaha.108.188649  0.8
2009 Hsu S, Nagayama T, Koitabashi N, Zhang M, Zhou L, Bedja D, Gabrielson KL, Molkentin JD, Kass DA, Takimoto E. Phosphodiesterase 5 inhibition blocks pressure overload-induced cardiac hypertrophy independent of the calcineurin pathway. Cardiovascular Research. 81: 301-9. PMID 19029137 DOI: 10.1093/Cvr/Cvn324  0.84
2008 Conway SJ, Molkentin JD. Periostin as a heterofunctional regulator of cardiac development and disease. Current Genomics. 9: 548-55. PMID 19516962 DOI: 10.2174/138920208786847917  0.84
2008 Blanchard C, Mingler MK, McBride M, Putnam PE, Collins MH, Chang G, Stringer K, Abonia JP, Molkentin JD, Rothenberg ME. Periostin facilitates eosinophil tissue infiltration in allergic lung and esophageal responses. Mucosal Immunology. 1: 289-96. PMID 19079190 DOI: 10.1038/Mi.2008.15  0.84
2008 Krenz M, Gulick J, Osinska HE, Colbert MC, Molkentin JD, Robbins J. Role of ERK1/2 signaling in congenital valve malformations in Noonan syndrome. Proceedings of the National Academy of Sciences of the United States of America. 105: 18930-5. PMID 19017799 DOI: 10.1073/Pnas.0806556105  0.84
2008 Jaleel N, Nakayama H, Chen X, Kubo H, MacDonnell S, Zhang H, Berretta R, Robbins J, Cribbs L, Molkentin JD, Houser SR. Ca2+ influx through T- and L-type Ca2+ channels have different effects on myocyte contractility and induce unique cardiac phenotypes. Circulation Research. 103: 1109-19. PMID 18832749 DOI: 10.1161/Circresaha.108.185611  0.84
2008 Nieves-Cintrón M, Amberg GC, Navedo MF, Molkentin JD, Santana LF. The control of Ca2+ influx and NFATc3 signaling in arterial smooth muscle during hypertension. Proceedings of the National Academy of Sciences of the United States of America. 105: 15623-8. PMID 18832165 DOI: 10.1073/Pnas.0808759105  0.84
2008 Da Costa Martins PA, Bourajjaj M, Gladka M, Kortland M, Van Oort RJ, Pinto YM, Molkentin JD, De Windt LJ. Conditional Dicer gene deletion in the postnatal myocardium provokes spontaneous cardiac remodeling Circulation. 118: 1567-1576. PMID 18809798 DOI: 10.1161/Circulationaha.108.769984  0.84
2008 Du H, Guo L, Fang F, Chen D, Sosunov AA, McKhann GM, Yan Y, Wang C, Zhang H, Molkentin JD, Gunn-Moore FJ, Vonsattel JP, Arancio O, Chen JX, Yan SD. Cyclophilin D deficiency attenuates mitochondrial and neuronal perturbation and ameliorates learning and memory in Alzheimer's disease. Nature Medicine. 14: 1097-105. PMID 18806802 DOI: 10.1038/Nm.1868  0.84
2008 Maillet M, Purcell NH, Sargent MA, York AJ, Bueno OF, Molkentin JD. DUSP6 (MKP3) null mice show enhanced ERK1/2 phosphorylation at baseline and increased myocyte proliferation in the heart affecting disease susceptibility. The Journal of Biological Chemistry. 283: 31246-55. PMID 18753132 DOI: 10.1074/Jbc.M806085200  0.84
2008 Houser SR, Molkentin JD. Does contractile Ca2+ control calcineurin-NFAT signaling and pathological hypertrophy in cardiac myocytes? Science Signaling. 1: pe31. PMID 18577756 DOI: 10.1126/Scisignal.125Pe31  0.84
2008 Fuller SJ, Pikkarainen S, Tham el L, Cullingford TE, Molkentin JD, Cornils H, Hergovich A, Hemmings BA, Clerk A, Sugden PH. Nuclear Dbf2-related protein kinases (NDRs) in isolated cardiac myocytes and the myocardium: activation by cellular stresses and by phosphoprotein serine-/threonine-phosphatase inhibitors. Cellular Signalling. 20: 1564-77. PMID 18555663 DOI: 10.1016/J.Cellsig.2008.04.013  0.84
2008 Snider P, Hinton RB, Moreno-Rodriguez RA, Wang J, Rogers R, Lindsley A, Li F, Ingram DA, Menick D, Field L, Firulli AB, Molkentin JD, Markwald R, Conway SJ. Periostin is required for maturation and extracellular matrix stabilization of noncardiomyocyte lineages of the heart. Circulation Research. 102: 752-60. PMID 18296617 DOI: 10.1161/Circresaha.107.159517  0.84
2008 Pinz I, Ostroy SE, Hoyer K, Osinska H, Robbins J, Molkentin JD, Ingwall JS. Calcineurin-induced energy wasting in a transgenic mouse model of heart failure. American Journal of Physiology. Heart and Circulatory Physiology. 294: H1459-66. PMID 18192216 DOI: 10.1152/Ajpheart.00911.2007  0.84
2008 Sahin B, Hawasli AH, Greene RW, Molkentin JD, Bibb JA. Negative regulation of cyclin-dependent kinase 5 targets by protein kinase C. European Journal of Pharmacology. 581: 270-5. PMID 18190909 DOI: 10.1016/J.Ejphar.2007.11.061  0.84
2008 Manicassamy S, Gupta S, Huang Z, Molkentin JD, Shang W, Sun Z. Requirement of calcineurin a beta for the survival of naive T cells. Journal of Immunology (Baltimore, Md. : 1950). 180: 106-12. PMID 18097009 DOI: 10.4049/Jimmunol.180.1.106  0.84
2007 Hambleton M, York A, Sargent MA, Kaiser RA, Lorenz JN, Robbins J, Molkentin JD. Inducible and myocyte-specific inhibition of PKCalpha enhances cardiac contractility and protects against infarction-induced heart failure. American Journal of Physiology. Heart and Circulatory Physiology. 293: H3768-71. PMID 17921332 DOI: 10.1152/Ajpheart.00486.2007  0.84
2007 Purcell NH, Wilkins BJ, York A, Saba-El-Leil MK, Meloche S, Robbins J, Molkentin JD. Genetic inhibition of cardiac ERK1/2 promotes stress-induced apoptosis and heart failure but has no effect on hypertrophy in vivo. Proceedings of the National Academy of Sciences of the United States of America. 104: 14074-9. PMID 17709754 DOI: 10.1073/Pnas.0610906104  0.84
2007 Nakayama H, Chen X, Baines CP, Klevitsky R, Zhang X, Zhang H, Jaleel N, Chua BH, Hewett TE, Robbins J, Houser SR, Molkentin JD. Ca2+- and mitochondrial-dependent cardiomyocyte necrosis as a primary mediator of heart failure. The Journal of Clinical Investigation. 117: 2431-44. PMID 17694179 DOI: 10.1172/Jci31060  0.84
2007 Davies KJ, Ermak G, Rothermel BA, Pritchard M, Heitman J, Ahnn J, Henrique-Silva F, Crawford D, Canaider S, Strippoli P, Carinci P, Min KT, Fox DS, Cunningham KW, Bassel-Duby R, ... ... Molkentin JD, et al. Renaming the DSCR1/Adapt78 gene family as RCAN: regulators of calcineurin. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 21: 3023-8. PMID 17595344 DOI: 10.1096/Fj.06-7246Com  0.84
2007 Oka T, Xu J, Kaiser RA, Melendez J, Hambleton M, Sargent MA, Lorts A, Brunskill EW, Dorn GW, Conway SJ, Aronow BJ, Robbins J, Molkentin JD. Genetic manipulation of periostin expression reveals a role in cardiac hypertrophy and ventricular remodeling. Circulation Research. 101: 313-21. PMID 17569887 DOI: 10.1016/J.Cardfail.2007.06.236  0.84
2007 Diwan A, Koesters AG, Odley AM, Pushkaran S, Baines CP, Spike BT, Daria D, Jegga AG, Geiger H, Aronow BJ, Molkentin JD, Macleod KF, Kalfa TA, Dorn GW. Unrestrained erythroblast development in Nix-/- mice reveals a mechanism for apoptotic modulation of erythropoiesis. Proceedings of the National Academy of Sciences of the United States of America. 104: 6794-9. PMID 17420462 DOI: 10.1073/Pnas.0610666104  0.84
2007 Baines CP, Kaiser RA, Sheiko T, Craigen WJ, Molkentin JD. Voltage-dependent anion channels are dispensable for mitochondrial-dependent cell death. Nature Cell Biology. 9: 550-5. PMID 17417626 DOI: 10.1038/Ncb1575  0.84
2007 Parsons SA, Millay DP, Sargent MA, Naya FJ, McNally EM, Sweeney HL, Molkentin JD. Genetic disruption of calcineurin improves skeletal muscle pathology and cardiac disease in a mouse model of limb-girdle muscular dystrophy. The Journal of Biological Chemistry. 282: 10068-78. PMID 17289669 DOI: 10.1074/Jbc.M609368200  0.84
2007 Peng J, Raddatz K, Molkentin JD, Wu Y, Labeit S, Granzier H, Gotthardt M. Cardiac hypertrophy and reduced contractility in hearts deficient in the titin kinase region. Circulation. 115: 743-51. PMID 17261657 DOI: 10.1161/Circulationaha.106.645499  0.84
2007 Norris RA, Damon B, Mironov V, Kasyanov V, Ramamurthi A, Moreno-Rodriguez R, Trusk T, Potts JD, Goodwin RL, Davis J, Hoffman S, Wen X, Sugi Y, Kern CB, Mjaatvedt CH, ... ... Molkentin JD, et al. Periostin regulates collagen fibrillogenesis and the biomechanical properties of connective tissues. Journal of Cellular Biochemistry. 101: 695-711. PMID 17226767 DOI: 10.1002/Jcb.21224  0.84
2007 Xiong D, Yajima T, Lim BK, Stenbit A, Dublin A, Dalton ND, Summers-Torres D, Molkentin JD, Duplain H, Wessely R, Chen J, Knowlton KU. Inducible cardiac-restricted expression of enteroviral protease 2A is sufficient to induce dilated cardiomyopathy. Circulation. 115: 94-102. PMID 17190866 DOI: 10.1161/Circulationaha.106.631093  0.84
2007 Amberg GC, Navedo MF, Nieves-Cintrón M, Molkentin JD, Santana LF. Calcium sparklets regulate local and global calcium in murine arterial smooth muscle. The Journal of Physiology. 579: 187-201. PMID 17158168 DOI: 10.1113/Jphysiol.2006.124420  0.84
2007 Nieves-Cintrón M, Amberg GC, Nichols CB, Molkentin JD, Santana LF. Activation of NFATc3 down-regulates the beta1 subunit of large conductance, calcium-activated K+ channels in arterial smooth muscle and contributes to hypertension. The Journal of Biological Chemistry. 282: 3231-40. PMID 17148444 DOI: 10.1074/Jbc.M608822200  0.84
2006 Gong N, Bodi I, Zobel C, Schwartz A, Molkentin JD, Backx PH. Calcineurin increases cardiac transient outward K+ currents via transcriptional up-regulation of Kv4.2 channel subunits. The Journal of Biological Chemistry. 281: 38498-506. PMID 17060317 DOI: 10.1074/Jbc.M607774200  0.84
2006 Hambleton M, Hahn H, Pleger ST, Kuhn MC, Klevitsky R, Carr AN, Kimball TF, Hewett TE, Dorn GW, Koch WJ, Molkentin JD. Pharmacological- and gene therapy-based inhibition of protein kinase Cα/β enhances cardiac contractility and attenuates heart failure Circulation. 114: 574-582. PMID 16880328 DOI: 10.1161/Circulationaha.105.592550  0.84
2006 Xin M, Davis CA, Molkentin JD, Lien CL, Duncan SA, Richardson JA, Olson EN. A threshold of GATA4 and GATA6 expression is required for cardiovascular development. Proceedings of the National Academy of Sciences of the United States of America. 103: 11189-94. PMID 16847256 DOI: 10.1073/Pnas.0604604103  0.76
2006 Obasanjo-Blackshire K, Mesquita R, Jabr RI, Molkentin JD, Hart SL, Marber MS, Xia Y, Heads RJ. Calcineurin regulates NFAT-dependent iNOS expression and protection of cardiomyocytes: co-operation with Src tyrosine kinase. Cardiovascular Research. 71: 672-83. PMID 16828070 DOI: 10.1016/J.Cardiores.2006.05.026  0.84
2006 Sahin B, Shu H, Fernandez J, El-Armouche A, Molkentin JD, Nairn AC, Bibb JA. Phosphorylation of protein phosphatase inhibitor-1 by protein kinase C. The Journal of Biological Chemistry. 281: 24322-35. PMID 16772299 DOI: 10.1074/Jbc.M603282200  0.84
2006 Chen X, Shevtsov SP, Hsich E, Cui L, Haq S, Aronovitz M, Kerkelä R, Molkentin JD, Liao R, Salomon RN, Patten R, Force T. The β-catenin/T-cell factor/lymphocyte enhancer factor signaling pathway is required for normal and stress-induced cardiac hypertrophy Molecular and Cellular Biology. 26: 4462-4473. PMID 16738313 DOI: 10.1128/Mcb.02157-05  0.84
2006 Parsons SA, Millay DP, Sargent MA, McNally EM, Molkentin JD. Age-dependent effect of myostatin blockade on disease severity in a murine model of limb-girdle muscular dystrophy. The American Journal of Pathology. 168: 1975-85. PMID 16723712 DOI: 10.2353/Ajpath.2006.051316  0.84
2006 Navedo MF, Amberg GC, Nieves M, Molkentin JD, Santana LF. Mechanisms underlying heterogeneous Ca2+ sparklet activity in arterial smooth muscle. The Journal of General Physiology. 127: 611-22. PMID 16702354 DOI: 10.1085/Jgp.200609519  0.84
2006 Liu Q, Wilkins BJ, Lee YJ, Ichijo H, Molkentin JD. Direct interaction and reciprocal regulation between ASK1 and calcineurin-NFAT control cardiomyocyte death and growth. Molecular and Cellular Biology. 26: 3785-97. PMID 16648474 DOI: 10.1128/Mcb.26.10.3785-3797.2006  0.84
2006 Sanna B, Brandt EB, Kaiser RA, Pfluger P, Witt SA, Kimball TR, van Rooij E, De Windt LJ, Rothenberg ME, Tschop MH, Benoit SC, Molkentin JD. Modulatory calcineurin-interacting proteins 1 and 2 function as calcineurin facilitators in vivo. Proceedings of the National Academy of Sciences of the United States of America. 103: 7327-32. PMID 16648267 DOI: 10.1073/Pnas.0509340103  0.84
2006 Oka T, Maillet M, Watt AJ, Schwartz RJ, Aronow BJ, Duncan SA, Molkentin JD. Cardiac-specific deletion of Gata4 reveals its requirement for hypertrophy, compensation, and myocyte viability. Circulation Research. 98: 837-45. PMID 16514068 DOI: 10.1161/01.Res.0000215985.18538.C4  0.84
2006 Zhao W, Yuan Q, Qian J, Waggoner JR, Pathak A, Chu G, Mitton B, Sun X, Jin J, Braz JC, Hahn HS, Marreez Y, Syed F, Pollesello P, Annila A, ... ... Molkentin JD, et al. The presence of Lys27 instead of Asn27 in human phospholamban promotes sarcoplasmic reticulum Ca2+-ATPase superinhibition and cardiac remodeling. Circulation. 113: 995-1004. PMID 16476846 DOI: 10.1161/Circulationaha.105.583351  0.84
2006 Xu J, Kimball TR, Lorenz JN, Brown DA, Bauskin AR, Klevitsky R, Hewett TE, Breit SN, Molkentin JD. GDF15/MIC-1 functions as a protective and antihypertrophic factor released from the myocardium in association with SMAD protein activation. Circulation Research. 98: 342-50. PMID 16397142 DOI: 10.1161/01.Res.0000202804.84885.D0  0.84
2005 Kaiser RA, Lyons JM, Duffy JY, Wagner CJ, McLean KM, O'Neill TP, Pearl JM, Molkentin JD. Inhibition of p38 reduces myocardial infarction injury in the mouse but not pig after ischemia-reperfusion. American Journal of Physiology. Heart and Circulatory Physiology. 289: H2747-51. PMID 16143643 DOI: 10.1152/Ajpheart.01280.2004  0.84
2005 Li J, Patel VV, Kostetskii I, Xiong Y, Chu AF, Jacobson JT, Yu C, Morley GE, Molkentin JD, Radice GL. Cardiac-specific loss of N-cadherin leads to alteration in connexins with conduction slowing and arrhythmogenesis. Circulation Research. 97: 474-81. PMID 16100040 DOI: 10.1161/01.Res.0000181132.11393.18  0.84
2005 Kaiser RA, Liang Q, Bueno O, Huang Y, Lackey T, Klevitsky R, Hewett TE, Molkentin JD. Genetic inhibition or activation of JNK1/2 protects the myocardium from ischemia-reperfusion-induced cell death in vivo. The Journal of Biological Chemistry. 280: 32602-8. PMID 16043490 DOI: 10.1074/Jbc.M500684200  0.84
2005 Baines CP, Kaiser RA, Purcell NH, Blair NS, Osinska H, Hambleton MA, Brunskill EW, Sayen MR, Gottlieb RA, Dorn GW, Robbins J, Molkentin JD. Loss of cyclophilin D reveals a critical role for mitochondrial permeability transition in cell death. Nature. 434: 658-62. PMID 15800627 DOI: 10.1038/Nature03434  0.84
2005 Heineke J, Ruetten H, Willenbockel C, Gross SC, Naguib M, Schaefer A, Kempf T, Hilfiker-Kleiner D, Caroni P, Kraft T, Kaiser RA, Molkentin JD, Drexler H, Wollert KC. Attenuation of cardiac remodeling after myocardial infarction by muscle LIM protein-calcineurin signaling at the sarcomeric Z-disc. Proceedings of the National Academy of Sciences of the United States of America. 102: 1655-60. PMID 15665106 DOI: 10.1073/Pnas.0405488102  0.84
2005 Sanna B, Bueno OF, Dai YS, Wilkins BJ, Molkentin JD. Direct and indirect interactions between calcineurin-NFAT and MEK1-extracellular signal-regulated kinase 1/2 signaling pathways regulate cardiac gene expression and cellular growth. Molecular and Cellular Biology. 25: 865-78. PMID 15657416 DOI: 10.1128/Mcb.25.3.865-878.2005  0.84
2004 Wilkins BJ, Molkentin JD. Calcium-calcineurin signaling in the regulation of cardiac hypertrophy. Biochemical and Biophysical Research Communications. 322: 1178-91. PMID 15336966 DOI: 10.1016/J.Bbrc.2004.07.121  0.84
2004 Lips DJ, Bueno OF, Wilkins BJ, Purcell NH, Kaiser RA, Lorenz JN, Voisin L, Saba-El-Leil MK, Meloche S, Pouysségur J, Pagès G, De Windt LJ, Doevendans PA, Molkentin JD. MEK1-ERK2 signaling pathway protects myocardium from ischemic injury in vivo. Circulation. 109: 1938-41. PMID 15096454 DOI: 10.1161/01.Cir.0000127126.73759.23  0.84
2004 Parsons SA, Millay DP, Wilkins BJ, Bueno OF, Tsika GL, Neilson JR, Liberatore CM, Yutzey KE, Crabtree GR, Tsika RW, Molkentin JD. Genetic loss of calcineurin blocks mechanical overload-induced skeletal muscle fiber type switching but not hypertrophy. The Journal of Biological Chemistry. 279: 26192-200. PMID 15082723 DOI: 10.1074/Jbc.M313800200  0.84
2004 Michael A, Haq S, Chen X, Hsich E, Cui L, Walters B, Shao Z, Bhattacharya K, Kilter H, Huggins G, Andreucci M, Periasamy M, Solomon RN, Liao R, Patten R, ... Molkentin JD, et al. Glycogen synthase kinase-3beta regulates growth, calcium homeostasis, and diastolic function in the heart. The Journal of Biological Chemistry. 279: 21383-93. PMID 15020584 DOI: 10.1074/Jbc.M401413200  0.84
2004 Braz JC, Gregory K, Pathak A, Zhao W, Sahin B, Klevitsky R, Kimball TF, Lorenz JN, Nairn AC, Liggett SB, Bodi I, Wang S, Schwartz A, Lakatta EG, DePaoli-Roach AA, ... ... Molkentin JD, et al. PKC-alpha regulates cardiac contractility and propensity toward heart failure. Nature Medicine. 10: 248-54. PMID 14966518 DOI: 10.1038/Nm1000  0.84
2004 Kaiser RA, Bueno OF, Lips DJ, Doevendans PA, Jones F, Kimball TF, Molkentin JD. Targeted inhibition of p38 mitogen-activated protein kinase antagonizes cardiac injury and cell death following ischemia-reperfusion in vivo. The Journal of Biological Chemistry. 279: 15524-30. PMID 14749328 DOI: 10.1074/Jbc.M313717200  0.84
2004 Lange AW, Molkentin JD, Yutzey KE. DSCR1 gene expression is dependent on NFATc1 during cardiac valve formation and colocalizes with anomalous organ development in trisomy 16 mice. Developmental Biology. 266: 346-60. PMID 14738882 DOI: 10.1016/J.Ydbio.2003.10.036  0.84
2004 Purcell NH, Darwis D, Bueno OF, Müller JM, Schüle R, Molkentin JD. Extracellular signal-regulated kinase 2 interacts with and is negatively regulated by the LIM-only protein FHL2 in cardiomyocytes. Molecular and Cellular Biology. 24: 1081-95. PMID 14729955 DOI: 10.1128/Mcb.24.3.1081-1095.2004  0.84
2004 Wilkins BJ, Dai YS, Bueno OF, Parsons SA, Xu J, Plank DM, Jones F, Kimball TR, Molkentin JD. Calcineurin/NFAT coupling participates in pathological, but not physiological, cardiac hypertrophy. Circulation Research. 94: 110-8. PMID 14656927 DOI: 10.1161/01.Res.0000109415.17511.18  0.84
2004 Bueno OF, Lips DJ, Kaiser RA, Wilkins BJ, Dai YS, Glascock BJ, Klevitsky R, Hewett TE, Kimball TR, Aronow BJ, Doevendans PA, Molkentin JD. Calcineurin Abeta gene targeting predisposes the myocardium to acute ischemia-induced apoptosis and dysfunction. Circulation Research. 94: 91-9. PMID 14615291 DOI: 10.1161/01.Res.0000107197.99679.77  0.84
2003 Prabhakar R, Petrashevskaya N, Schwartz A, Aronow B, Boivin GP, Molkentin JD, Wieczorek DF. A mouse model of familial hypertrophic cardiomyopathy caused by a alpha-tropomyosin mutation. Molecular and Cellular Biochemistry. 251: 33-42. PMID 14575301 DOI: 10.1023/A:1025409227350  0.84
2003 Liang Q, Bueno OF, Wilkins BJ, Kuan CY, Xia Y, Molkentin JD. c-Jun N-terminal kinases (JNK) antagonize cardiac growth through cross-talk with calcineurin-NFAT signaling. The Embo Journal. 22: 5079-89. PMID 14517246 DOI: 10.1093/Emboj/Cdg474  0.84
2003 Haq S, Kilter H, Michael A, Tao J, O'Leary E, Sun XM, Walters B, Bhattacharya K, Chen X, Cui L, Andreucci M, Rosenzweig A, Guerrero JL, Patten R, Liao R, ... Molkentin J, et al. Deletion of cytosolic phospholipase A2 promotes striated muscle growth Nature Medicine. 9: 944-951. PMID 12808451 DOI: 10.1038/Nm891  0.84
2003 Parsons SA, Wilkins BJ, Bueno OF, Molkentin JD. Altered skeletal muscle phenotypes in calcineurin Aalpha and Abeta gene-targeted mice. Molecular and Cellular Biology. 23: 4331-43. PMID 12773574 DOI: 10.1128/Mcb.23.12.4331-4343.2003  0.84
2003 Braz JC, Bueno OF, Liang Q, Wilkins BJ, Dai YS, Parsons S, Braunwart J, Glascock BJ, Klevitsky R, Kimball TF, Hewett TE, Molkentin JD. Targeted inhibition of p38 MAPK promotes hypertrophic cardiomyopathy through upregulation of calcineurin-NFAT signaling. The Journal of Clinical Investigation. 111: 1475-86. PMID 12750397 DOI: 10.1172/Jci17295  0.84
2003 Gajewski K, Wang J, Molkentin JD, Chen EH, Olson EN, Schulz RA. Requirement of the calcineurin subunit gene canB2 for indirect flight muscle formation in Drosophila. Proceedings of the National Academy of Sciences of the United States of America. 100: 1040-5. PMID 12538857 DOI: 10.1073/Pnas.0337662100  0.84
2002 Bueno OF, Molkentin JD. Involvement of extracellular signal-regulated kinases 1/2 in cardiac hypertrophy and cell death. Circulation Research. 91: 776-81. PMID 12411391 DOI: 10.1161/01.Res.0000038488.38975.1A  0.84
2002 Wilkins BJ, De Windt LJ, Bueno OF, Braz JC, Glascock BJ, Kimball TF, Molkentin JD. Targeted disruption of NFATc3, but not NFATc4, reveals an intrinsic defect in calcineurin-mediated cardiac hypertrophic growth. Molecular and Cellular Biology. 22: 7603-13. PMID 12370307 DOI: 10.1128/Mcb.22.21.7603-7613.2002  0.84
2002 Lynch RA, Wagoner L, Li S, Sparks L, Molkentin J, Dorn GW. Novel and nondetected human signaling protein polymorphisms Physiol Genomics. 10: 159-168. PMID 12209018 DOI: 10.1152/Physiolgenomics.00030.2002  0.84
2002 Fiedler B, Lohmann SM, Smolenski A, Linnemuller S, Pieske B, Schroder F, Molkentin JD, Drexler H, Wollert KC. Inhibition of calcineurin-NFAT hypertrophy signaling by cGMP-dependent protein kinase type I in cardiac myocytes. Proceedings of the National Academy of Sciences of the United States of America. 99: 11363-8. PMID 12177418 DOI: 10.1073/Pnas.162100799  0.84
2002 Jacob A, Molkentin JD, Smolenski A, Lohmann SM, Begum N. Insulin inhibits PDGF-directed VSMC migration via NO/ cGMP increase of MKP-1 and its inactivation of MAPKs. American Journal of Physiology. Cell Physiology. 283: C704-13. PMID 12176727 DOI: 10.1152/Ajpcell.00110.2002  0.84
2002 Bueno OF, Brandt EB, Rothenberg ME, Molkentin JD. Defective T cell development and function in calcineurin A beta -deficient mice. Proceedings of the National Academy of Sciences of the United States of America. 99: 9398-403. PMID 12091710 DOI: 10.1073/Pnas.152665399  0.84
2002 Petrashevskaya NN, Bodi I, Rubio M, Molkentin JD, Schwartz A. Cardiac function and electrical remodeling of the calcineurin-overexpressed transgenic mouse. Cardiovascular Research. 54: 117-32. PMID 12062368 DOI: 10.1016/S0008-6363(02)00241-9  0.84
2002 Liang Q, Molkentin JD. Divergent signaling pathways converge on GATA4 to regulate cardiac hypertrophic gene expression Journal of Molecular and Cellular Cardiology. 34: 611-616. PMID 12054848 DOI: 10.1006/Jmcc.2002.2011  0.84
2002 Wilkins BJ, Molkentin JD. Calcineurin and cardiac hypertrophy: where have we been? Where are we going? The Journal of Physiology. 541: 1-8. PMID 12015416 DOI: 10.1113/Jphysiol.2002.017129  0.84
2002 Dai YS, Cserjesi P, Markham BE, Molkentin JD. The transcription factors GATA4 and dHAND physically interact to synergistically activate cardiac gene expression through a p300-dependent mechanism. The Journal of Biological Chemistry. 277: 24390-8. PMID 11994297 DOI: 10.1074/Jbc.M202490200  0.84
2002 Donelan MJ, Morfini G, Julyan R, Sommers S, Hays L, Kajio H, Briaud I, Easom RA, Molkentin JD, Brady ST, Rhodes CJ. Ca2+-dependent dephosphorylation of kinesin heavy chain on beta-granules in pancreatic beta-cells. Implications for regulated beta-granule transport and insulin exocytosis. The Journal of Biological Chemistry. 277: 24232-42. PMID 11978799 DOI: 10.1074/jbc.M203345200  0.84
2002 Bueno OF, van Rooij E, Molkentin JD, Doevendans PA, De Windt LJ. Calcineurin and hypertrophic heart disease: novel insights and remaining questions. Cardiovascular Research. 53: 806-21. PMID 11922891 DOI: 10.1016/S0008-6363(01)00493-X  0.84
2002 Bueno OF, Wilkins BJ, Tymitz KM, Glascock BJ, Kimball TF, Lorenz JN, Molkentin JD. Impaired cardiac hypertrophic response in Calcineurin Abeta -deficient mice. Proceedings of the National Academy of Sciences of the United States of America. 99: 4586-91. PMID 11904392 DOI: 10.1073/Pnas.072647999  0.84
2002 Braz JC, Bueno OF, De Windt LJ, Molkentin JD. PKC alpha regulates the hypertrophic growth of cardiomyocytes through extracellular signal-regulated kinase1/2 (ERK1/2). The Journal of Cell Biology. 156: 905-19. PMID 11864993 DOI: 10.1083/Jcb.200108062  0.84
2001 Charron F, Tsimiklis G, Arcand M, Robitaille L, Liang Q, Molkentin JD, Meloche S, Nemer M. Tissue-specific GATA factors are transcriptional effectors of the small GTPase RhoA. Genes & Development. 15: 2702-19. PMID 11641276 DOI: 10.1101/Gad.915701  0.84
2001 Liang Q, Wiese RJ, Bueno OF, Dai YS, Markham BE, Molkentin JD. The transcription factor GATA4 is activated by extracellular signal-regulated kinase 1- and 2-mediated phosphorylation of serine 105 in cardiomyocytes. Molecular and Cellular Biology. 21: 7460-9. PMID 11585926 DOI: 10.1128/Mcb.21.21.7460-7469.2001  0.84
2001 Qiao L, Studer E, Leach K, McKinstry R, Gupta S, Decker R, Kukreja R, Valerie K, Nagarkatti P, El Deiry W, Molkentin J, Schmidt-Ullrich R, Fisher PB, Grant S, Hylemon PB, et al. Deoxycholic acid (DCA) causes ligand-independent activation of epidermal growth factor receptor (EGFR) and FAS receptor in primary hepatocytes: Inhibition of EGFR/mitogen-activated protein kinase-signaling module enhances DCA-induced apoptosis Molecular Biology of the Cell. 12: 2629-2645. PMID 11553704 DOI: 10.1091/Mbc.12.9.2629  0.84
2001 Li J, Molkentin JD, Colbert MC. Retinoic acid inhibits cardiac neural crest migration by blocking c-Jun N-terminal kinase activation. Developmental Biology. 232: 351-61. PMID 11401397 DOI: 10.1006/Dbio.2001.0203  0.84
2001 Aronow BJ, Toyokawa T, Canning A, Haghighi K, Delling U, Kranias E, Molkentin JD, Dorn GW. Divergent transcriptional responses to independent genetic causes of cardiac hypertrophy Physiological Genomics. 6: 19-28. PMID 11395543 DOI: 10.1152/Physiolgenomics.2001.6.1.19  0.84
2001 Crispino JD, Lodish MB, Thurberg BL, Litovsky SH, Collins T, Molkentin JD, Orkin SH. Proper coronary vascular development and heart morphogenesis depend on interaction of GATA-4 with FOG cofactors Genes and Development. 15: 839-844. PMID 11297508 DOI: 10.1101/Gad.875201  0.84
2001 Lim HW, New L, Han J, Molkentin JD. Calcineurin enhances MAPK phosphatase-1 expression and p38 MAPK inactivation in cardiac myocytes. The Journal of Biological Chemistry. 276: 15913-9. PMID 11279073 DOI: 10.1074/Jbc.M100452200  0.84
2001 De Windt LJ, Lim HW, Bueno OF, Liang Q, Delling U, Braz JC, Glascock BJ, Kimball TF, del Monte F, Hajjar RJ, Molkentin JD. Targeted inhibition of calcineurin attenuates cardiac hypertrophy in vivo. Proceedings of the National Academy of Sciences of the United States of America. 98: 3322-7. PMID 11248077 DOI: 10.1073/Pnas.031371998  0.84
2001 Bueno OF, De Windt LJ, Lim HW, Tymitz KM, Witt SA, Kimball TR, Molkentin JD. The dual-specificity phosphatase MKP-1 limits the cardiac hypertrophic response in vitro and in vivo. Circulation Research. 88: 88-96. PMID 11139479 DOI: 10.1161/01.Res.88.1.88  0.84
2000 Bueno OF, De Windt LJ, Tymitz KM, Witt SA, Kimball TR, Klevitsky R, Hewett TE, Jones SP, Lefer DJ, Peng CF, Kitsis RN, Molkentin JD. The MEK1-ERK1/2 signaling pathway promotes compensated cardiac hypertrophy in transgenic mice. The Embo Journal. 19: 6341-50. PMID 11101507 DOI: 10.1093/Emboj/19.23.6341  0.84
2000 Molkentin JD, Tymitz KM, Richardson JA, Olson EN. Abnormalities of the genitourinary tract in female mice lacking GATA5. Molecular and Cellular Biology. 20: 5256-60. PMID 10866681 DOI: 10.1128/Mcb.20.14.5256-5260.2000  0.36
2000 De Windt LJ, Lim HW, Taigen T, Wencker D, Condorelli G, Dorn GW, Kitsis RN, Molkentin JD. Calcineurin-mediated hypertrophy protects cardiomyocytes from apoptosis in vitro and in vivo. An apoptosis-independent model of dilated heart failure Circulation Research. 86: 255-263. PMID 10679475 DOI: 10.1161/01.Res.86.3.255  0.84
1999 Olson EN, Molkentin JD. Prevention of cardiac hypertrophy by calcineurin inhibition: hope or hype? Circulation Research. 84: 623-32. PMID 10189350 DOI: 10.1161/01.Res.84.6.623  0.48
1999 Wilson-Rawls J, Molkentin JD, Black BL, Olson EN. Activated notch inhibits myogenic activity of the MADS-Box transcription factor myocyte enhancer factor 2C. Molecular and Cellular Biology. 19: 2853-62. PMID 10082551 DOI: 10.1128/Mcb.19.4.2853  0.76
1998 Sussman MA, Lim HW, Gude N, Taigen T, Olson EN, Robbins J, Colbert MC, Gualberto A, Wieczorek DF, Molkentin JD. Prevention of cardiac hypertrophy in mice by calcineurin inhibition. Science (New York, N.Y.). 281: 1690-3. PMID 9733519 DOI: 10.1126/Science.281.5383.1690  0.84
1998 Molkentin JD, Lu JR, Antos CL, Markham B, Richardson J, Robbins J, Grant SR, Olson EN. A calcineurin-dependent transcriptional pathway for cardiac hypertrophy. Cell. 93: 215-28. PMID 9568714 DOI: 10.1016/S0092-8674(00)81573-1  0.76
1998 Black BL, Molkentin JD, Olson EN. Multiple roles for the MyoD basic region in transmission of transcriptional activation signals and interaction with MEF2. Molecular and Cellular Biology. 18: 69-77. PMID 9418854 DOI: 10.1128/Mcb.18.1.69  0.76
1996 Molkentin JD, Olson EN. Defining the regulatory networks for muscle development. Current Opinion in Genetics & Development. 6: 445-53. PMID 8791524 DOI: 10.1016/S0959-437X(96)80066-9  0.56
1996 Molkentin JD, Olson EN. Combinatorial control of muscle development by basic helix-loop-helix and MADS-box transcription factors. Proceedings of the National Academy of Sciences of the United States of America. 93: 9366-73. PMID 8790335 DOI: 10.1073/Pnas.93.18.9366  0.44
1996 Molkentin JD, Firulli AB, Black BL, Martin JF, Hustad CM, Copeland N, Jenkins N, Lyons G, Olson EN. MEF2B is a potent transactivator expressed in early myogenic lineages Molecular and Cellular Biology. 16: 3814-3824. PMID 8668199 DOI: 10.1128/Mcb.16.7.3814  0.84
1996 Molkentin JD, Li L, Olson EN. Phosphorylation of the MADS-Box transcription factor MEF2C enhances its DNA binding activity. The Journal of Biological Chemistry. 271: 17199-204. PMID 8663403 DOI: 10.1074/Jbc.271.29.17199  0.32
1996 Molkentin JD, Black BL, Martin JF, Olson EN. Mutational analysis of the DNA binding, dimerization, and transcriptional activation domains of MEF2C. Molecular and Cellular Biology. 16: 2627-36. PMID 8649370 DOI: 10.1128/Mcb.16.6.2627  0.76
1995 Molkentin JD, Black BL, Martin JF, Olson EN. Cooperative activation of muscle gene expression by MEF2 and myogenic bHLH proteins. Cell. 83: 1125-36. PMID 8548800 DOI: 10.1016/0092-8674(95)90139-6  0.76
1995 Ranganayakulu G, Zhao B, Dokidis A, Molkentin JD, Olson EN, Schulz RA. A series of mutations in the D-MEF2 transcription factor reveal multiple functions in larval and adult myogenesis in Drosophila. Developmental Biology. 171: 169-81. PMID 7556894 DOI: 10.1006/Dbio.1995.1269  0.84
1992 Barbieri JT, Armellini D, Molkentin J, Rappuoli R. Construction of a diphtheria toxin A fragment-C180 peptide fusion protein which elicits a neutralizing antibody response against diphtheria toxin and pertussis toxin Infection and Immunity. 60: 5071-5077. PMID 1452339 DOI: 10.1128/Iai.60.12.5071-5077.1992  0.84
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