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Jeffery D. Molkentin - Publications

Affiliations: 
University of Cincinnati, Cincinnati, OH 
Area:
Molecular Biology
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Year Citation  Score
2023 Baldwin TA, Teuber JP, Kuwabara Y, Subramani A, Lin SJ, Kanisicak O, Vagnozzi RJ, Zhang W, Brody MJ, Molkentin JD. Palmitoylation-Dependent Regulation of Cardiomyocyte Rac1 Signaling Activity and Minor Effects on Cardiac Hypertrophy. The Journal of Biological Chemistry. 105426. PMID 37926281 DOI: 10.1016/j.jbc.2023.105426  0.408
2023 Kuwabara Y, York AJ, Lin SC, Sargent MA, Grimes KM, Pirruccello JP, Molkentin JD. A human FLII gene variant alters sarcomeric actin thin filament length and predisposes to cardiomyopathy. Proceedings of the National Academy of Sciences of the United States of America. 120: e2213696120. PMID 37126682 DOI: 10.1073/pnas.2213696120  0.318
2023 Grimes KM, Prasad V, Huo J, Kuwabara Y, Vanhoutte D, Baldwin TA, Bowers SLK, Johansen AKZ, Sargent MA, Lin SJ, Molkentin JD. gene deletion in mice reduces heart weight over time. Frontiers in Physiology. 14: 1054169. PMID 36733907 DOI: 10.3389/fphys.2023.1054169  0.386
2022 Yan R, Cigliola V, Oonk KA, Petrover Z, DeLuca S, Wolfson DW, Vekstein A, Mendiola MA, Devlin G, Bishawi M, Gemberling MP, Sinha T, Sargent MA, York AJ, Shakked A, ... ... Molkentin JD, et al. An enhancer-based gene-therapy strategy for spatiotemporal control of cargoes during tissue repair. Cell Stem Cell. PMID 36516837 DOI: 10.1016/j.stem.2022.11.012  0.597
2022 Li Y, Li C, Liu Q, Wang L, Bao AX, Jung JP, Dodlapati S, Sun J, Gao P, Zhang X, Francis J, Molkentin JD, Fu X. Loss of Acta2 in cardiac fibroblasts does not prevent the myofibroblast differentiation or affect the cardiac repair after myocardial infarction. Journal of Molecular and Cellular Cardiology. 171: 117-132. PMID 36007455 DOI: 10.1016/j.yjmcc.2022.08.003  0.352
2021 Vanhoutte D, Schips TG, Vo A, Grimes KM, Baldwin TA, Brody MJ, Accornero F, Sargent MA, Molkentin JD. Thbs1 induces lethal cardiac atrophy through PERK-ATF4 regulated autophagy. Nature Communications. 12: 3928. PMID 34168130 DOI: 10.1038/s41467-021-24215-4  0.389
2021 Fischesser DM, Meyer EC, Sargent M, Molkentin JD. Refined CLARITY-Based Tissue Clearing for Three-Dimensional Fibroblast Organization in Healthy and Injured Mouse Hearts. Journal of Visualized Experiments : Jove. PMID 34057439 DOI: 10.3791/62023  0.346
2020 Singh SR, Meyer-Jens M, Alizoti E, Bacon WC, Davis G, Osinska H, Gulick J, Reischmann-Düsener S, Orthey E, McLendon PM, Molkentin JD, Schlossarek S, Robbins J, Carrier L. A high-throughput screening identifies ZNF418 as a novel regulator of the ubiquitin-proteasome system and autophagy-lysosomal pathway. Autophagy. PMID 33249983 DOI: 10.1080/15548627.2020.1856493  0.305
2020 Schriever SC, Kabra DG, Pfuhlmann K, Baumann P, Baumgart EV, Nagler J, Seebacher F, Harrison L, Irmler M, Kullmann S, Corrêa-da-Silva F, Giesert F, Jain R, Schug H, Castel J, ... ... Molkentin JD, et al. Type 2 diabetes risk gene Dusp8 regulates hypothalamic Jnk signaling and insulin sensitivity. The Journal of Clinical Investigation. PMID 32780722 DOI: 10.1172/Jci136363  0.313
2020 Bround MJ, Bers DM, Molkentin JD. A 20/20 view of ANT function in mitochondrial biology and necrotic cell death. Journal of Molecular and Cellular Cardiology. PMID 32454061 DOI: 10.1016/J.Yjmcc.2020.05.012  0.303
2020 Huo J, Lu S, Kwong JQ, Bround MJ, Grimes KM, Sargent MA, Brown ME, Davis ME, Bers DM, Molkentin JD. MCUb Induction Protects the Heart from Post-Ischemic Remodeling. Circulation Research. PMID 32299299 DOI: 10.1161/Circresaha.119.316369  0.4
2020 Vagnozzi RJ, Sargent MA, Molkentin JD. Cardiac Cell Therapy Rejuvenates the Infarcted Rodent Heart via Direct Injection but Not by Vascular Infusion. Circulation. 141: 1037-1039. PMID 32202933 DOI: 10.1161/Circulationaha.119.044686  0.38
2020 Lu S, Liao Z, Lu X, Katschinski DM, Mercola M, Chen J, Heller Brown J, Molkentin JD, Bossuyt J, Bers DM. Hyperglycemia Acutely Increases Cytosolic Reactive Oxygen Species via -linked GlcNAcylation and CaMKII Activation in Mouse Ventricular Myocytes. Circulation Research. PMID 32134364 DOI: 10.1161/Circresaha.119.316288  0.357
2020 Amanakis G, Sun J, Fergusson MM, McGinty S, Liu C, Molkentin JD, Murphy E. Cysteine 202 of Cyclophilin D is a site of multiple post-translational modifications and plays a role in cardioprotection. Cardiovascular Research. PMID 32129829 DOI: 10.1093/Cvr/Cvaa053  0.332
2020 Pereira AHM, Cardoso AC, Consonni SR, Oliveira RR, Saito A, Vaggione MLB, Matos-Souza JR, Carazzolle MF, Gonçalves A, Fernandes JL, Ribeiro GCA, Lopes MM, Molkentin JD, Franchini KG. MEF2C repressor variant deregulation leads to cell cycle re-entry and development of heart failure. Ebiomedicine. 51: 102571. PMID 31911274 DOI: 10.1016/J.Ebiom.2019.11.032  0.388
2019 Vagnozzi RJ, Maillet M, Sargent MA, Khalil H, Johansen AK, Schwanekamp JA, York AJ, Huang V, Nahrendorf M, Sadayappan S, Molkentin JD. An acute immune response underlies the benefit of cardiac stem-cell therapy. Nature. PMID 31775156 DOI: 10.1038/S41586-019-1802-2  0.415
2019 Antonucci S, Di Sante M, Sileikyte J, Deveraux J, Bauer T, Bround MJ, Menabò R, Paillard M, Alanova P, Carraro M, Ovize M, Molkentin JD, Cohen M, Forte MA, Bernardi P, et al. A novel class of cardioprotective small-molecule PTP inhibitors. Pharmacological Research. 104548. PMID 31759087 DOI: 10.1016/J.Phrs.2019.104548  0.343
2019 Johansen AKZ, Molkentin JD. Hippo signaling does it again: arbitrating cardiac fibroblast identity and activation. Genes & Development. 33: 1457-1459. PMID 31676733 DOI: 10.1101/Gad.332791.119  0.483
2019 Vagnozzi RJ, Johansen AKZ, Molkentin JD. CARdiac Immunotherapy: T Cells Engineered to Treat the Fibrotic Heart. Molecular Therapy : the Journal of the American Society of Gene Therapy. PMID 31585799 DOI: 10.1016/J.Ymthe.2019.09.021  0.382
2019 Karch J, Bround MJ, Khalil H, Sargent MA, Latchman N, Terada N, Peixoto PM, Molkentin JD. Inhibition of mitochondrial permeability transition by deletion of the ANT family and CypD. Science Advances. 5: eaaw4597. PMID 31489369 DOI: 10.1126/Sciadv.Aaw4597  0.358
2019 Khalil H, Kanisicak O, Vagnozzi RJ, Johansen AK, Maliken BD, Prasad V, Boyer JG, Brody MJ, Schips T, Kilian KK, Correll RN, Kawasaki K, Nagata K, Molkentin JD. Cell-specific ablation of Hsp47 defines the collagen-producing cells in the injured heart Jci Insight. 4: e128722. PMID 31393098 DOI: 10.1172/Jci.Insight.128722  0.46
2019 Murphy E, Bernardi P, Cohen M, Di Lisa F, Forte M, Molkentin JD, Ovize M. Fondation Leducq Transatlantic Network of Excellence Targeting Mitochondria to Treat Heart Disease. Circulation Research. 124: 1294-1296. PMID 31021720 DOI: 10.1161/Circresaha.119.314893  0.311
2019 Brody MJ, Vanhoutte D, Bakshi CV, Liu R, Correll RN, Sargent MA, Molkentin JD. Disruption of valosin-containing protein activity causes cardiomyopathy and reveals pleiotropic functions in cardiac homeostasis. The Journal of Biological Chemistry. PMID 31006653 DOI: 10.1074/Jbc.Ra119.007585  0.481
2019 Boyer JG, Prasad V, Song T, Lee D, Fu X, Grimes KM, Sargent MA, Sadayappan S, Molkentin JD. ERK1/2 signaling induces skeletal muscle slow fiber-type switching and reduces muscular dystrophy disease severity. Jci Insight. 5. PMID 30964448 DOI: 10.1172/Jci.Insight.127356  0.407
2019 Correll RN, Grimes KM, Prasad V, Lynch JM, Khalil H, Molkentin JD. Overlapping and differential functions of ATF6α versus ATF6β in the mouse heart. Scientific Reports. 9: 2059. PMID 30765833 DOI: 10.1038/S41598-019-39515-5  0.489
2019 Schips TG, Vanhoutte D, Vo A, Correll RN, Brody MJ, Khalil H, Karch J, Tjondrokoesoemo A, Sargent MA, Maillet M, Ross RS, Molkentin JD. Thrombospondin-3 augments injury-induced cardiomyopathy by intracellular integrin inhibition and sarcolemmal instability. Nature Communications. 10: 76. PMID 30622267 DOI: 10.1038/S41467-018-08026-8  0.392
2019 Altamimi TR, Karwi QG, Uddin GM, Fukushima A, Kwong JQ, Molkentin JD, Lopaschuk GD. Cardiac-specific deficiency of the mitochondrial calcium uniporter augments fatty acid oxidation and functional reserve. Journal of Molecular and Cellular Cardiology. 127: 223-231. PMID 30615880 DOI: 10.1016/J.Yjmcc.2018.12.019  0.387
2019 Lim HW, Molkentin JD. Reply to revisiting calcineurin and human heart failure Nature Medicine. 6: 3. PMID 10613794 DOI: 10.1038/71511  0.427
2019 Grimes KM, Pyo A, Molkentin JD. Abstract 918: Pre-B-cell Leukemia Homeobox Interacting Protein 1 is a Novel Regulator of Growth Signaling in the Heart Circulation Research. 125. DOI: 10.1161/Res.125.Suppl_1.918  0.385
2019 Khalil H, Jones SM, Alam P, Aronow BJ, Molkentin JD, Kanisicak O. Abstract 837: Different Disease States in Heart Have Distinct Cardiac Interstitial Cells Contributing to Fibrosis Circulation Research. 125. DOI: 10.1161/Res.125.Suppl_1.837  0.402
2019 Fu X, Liu Q, Wang L, Molkentin J. Abstract 828: The Functional Role of Myofibroblast-Expressed Smooth Muscle Alpha Actin in Post-Myocardial Infarction Tissue Healing Circulation Research. 125. DOI: 10.1161/Res.125.Suppl_1.828  0.307
2019 Kaikkonen LA, Sätzler V, Roy A, Contreras M, Xu B, Stroll S, McCarthy J, Molkentin JD, Das S, Kontaridis M. Abstract 252: Activated Fibroblast-specific Deletion of RhoA Reduces Cardiac Fibrosis Through Regulation of the Non-canonical p38-MAPK Signaling Pathway Circulation Research. 125. DOI: 10.1161/Res.125.Suppl_1.252  0.422
2019 Perera MM, Fischesser DM, Molkentin JD, Ayres N. Stiffness of thermoresponsive gelatin-based dynamic hydrogels affects fibroblast activation Polymer Chemistry. 10: 6360-6367. DOI: 10.1039/C9Py01424A  0.374
2018 Meng Q, Bhandary B, Bhuiyan MS, James J, Osinska H, Valiente-Alandi I, Shay-Winkler K, Gulick J, Molkentin JD, Blaxall BC, Robbins J. Myofibroblast-Specific TGFβ Receptor II Signaling in the Fibrotic Response to Cardiac Myosin Binding Protein C-Induced Cardiomyopathy. Circulation Research. 123: 1285-1297. PMID 30566042 DOI: 10.1161/Circresaha.118.313089  0.418
2018 Neidig LE, Weinberger F, Palpant NJ, Mignone J, Martinson AM, Sorensen DW, Bender I, Nemoto N, Reinecke H, Pabon L, Molkentin JD, Murry CE, van Berlo JH. Evidence for Minimal Cardiogenic Potential of Stem Cell Antigen 1-Positive Cells in the Adult Mouse Heart. Circulation. 138: 2960-2962. PMID 30566022 DOI: 10.1161/Circulationaha.118.035273  0.321
2018 Kwong JQ, Huo J, Bround MJ, Boyer JG, Schwanekamp JA, Ghazal N, Maxwell JT, Jang YC, Khuchua Z, Shi K, Bers DM, Davis J, Molkentin JD. The mitochondrial calcium uniporter underlies metabolic fuel preference in skeletal muscle. Jci Insight. 3. PMID 30429366 DOI: 10.1172/Jci.Insight.121689  0.353
2018 Bhandary B, Meng Q, James J, Osinska H, Gulick J, Valiente-Alandi I, Sargent MA, Bhuiyan MS, Blaxall BC, Molkentin JD, Robbins J. Cardiac Fibrosis in Proteotoxic Cardiac Disease is Dependent Upon Myofibroblast TGF -β Signaling. Journal of the American Heart Association. 7: e010013. PMID 30371263 DOI: 10.1161/Jaha.118.010013  0.429
2018 Maliken BD, Molkentin JD. Undeniable Evidence That the Adult Mammalian Heart Lacks an Endogenous Regenerative Stem Cell. Circulation. 138: 806-808. PMID 30359129 DOI: 10.1161/Circulationaha.118.035186  0.327
2018 Olivares-Florez S, Czolbe M, Riediger F, Seidlmayer L, Williams T, Nordbeck P, Strasen J, Glocker C, Jänsch M, Eder-Negrin P, Arias-Loza P, Mühlfelder M, Plačkić J, Heinze KG, Molkentin JD, et al. Nuclear calcineurin is a sensor for detecting Ca release from the nuclear envelope via IPR. Journal of Molecular Medicine (Berlin, Germany). PMID 30293136 DOI: 10.1007/S00109-018-1701-2  0.34
2018 Vagnozzi RJ, Sargent MA, Lin SJ, Palpant NJ, Murry CE, Molkentin JD. Genetic Lineage Tracing of Sca-1 Cells Reveals Endothelial but Not Myogenic Contribution to the Murine Heart. Circulation. PMID 29991486 DOI: 10.1161/Circulationaha.118.035210  0.449
2018 Vagnozzi RJ, Molkentin JD, Houser SR. New Myocyte Formation in the Adult Heart: Endogenous Sources and Therapeutic Implications. Circulation Research. 123: 159-176. PMID 29976685 DOI: 10.1161/Circresaha.118.311208  0.422
2018 Nayak G, Odaka Y, Prasad V, Solano AF, Yeo EJ, Vemaraju S, Molkentin JD, Trumpp A, Williams B, Rao S, Lang RA. Developmental vascular regression is regulated by a Wnt/β-catenin, MYC, P21 (CDKN1A) pathway that controls cell proliferation and cell death. Development (Cambridge, England). PMID 29777010 DOI: 10.1242/Dev.154898  0.329
2018 Brody MJ, Vanhoutte D, Schips TG, Boyer JG, Bakshi CV, Sargent MA, York AJ, Molkentin JD. Defective Flux of Thrombospondin-4 through the Secretory Pathway Impairs Cardiomyocyte Membrane Stability and Causes Cardiomyopathy. Molecular and Cellular Biology. PMID 29712757 DOI: 10.1128/Mcb.00114-18  0.387
2018 Maliken BD, Kanisicak O, Karch J, Khalil H, Fu X, Boyer JG, Prasad V, Zheng Y, Molkentin JD. Gata4-Dependent Differentiation of c-Kit Derived Endothelial Cells Underlies Artefactual Cardiomyocyte Regeneration in the Heart. Circulation. PMID 29666070 DOI: 10.1161/Circulationaha.118.033703  0.381
2018 Fu X, Khalil H, Kanisicak O, Boyer JG, Vagnozzi RJ, Maliken BD, Sargent MA, Prasad V, Valiente-Alandi I, Blaxall BC, Molkentin JD. Specialized fibroblast differentiated states underlie scar formation in the infarcted mouse heart. The Journal of Clinical Investigation. PMID 29664017 DOI: 10.1172/Jci98215  0.389
2018 Valiente-Alandi I, Potter SJ, Salvador AM, Schafer AE, Schips T, Carrillo-Salinas F, Gibson AM, Nieman ML, Perkins C, Sargent MA, Huo J, Lorenz JN, DeFalco T, Molkentin JD, Alcaide P, et al. Inhibiting Fibronectin Attenuates Fibrosis and Improves Cardiac Function in a Model of Heart Failure. Circulation. PMID 29653926 DOI: 10.1161/Circulationaha.118.034609  0.457
2018 Galluzzi L, Vitale I, Aaronson SA, Abrams JM, Adam D, Agostinis P, Alnemri ES, Altucci L, Amelio I, Andrews DW, Annicchiarico-Petruzzelli M, Antonov AV, Arama E, Baehrecke EH, Barlev NA, ... ... Molkentin JD, et al. Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018. Cell Death and Differentiation. PMID 29362479 DOI: 10.1038/S41418-017-0012-4  0.574
2018 Brody MJ, Vanhoutte D, Viswanathan MC, Nguyen T, Maillet M, York AJ, Sargent MA, Cammarato A, Molkentin JD. Abstract 548: Evolutionarily Conserved Functions for Valosin Containing Protein (VCP) in Cardiac and Skeletal Muscle Reveal Mechanistic Insights into Multisystem Proteinopathy Circulation Research. 123. DOI: 10.1161/Res.123.Suppl_1.548  0.395
2018 Grimes KM, Maillet M, Molkentin JD. Abstract 306: Identifying Downstream Effectors of the Extracellular Signal-related Kinase 1/2-controlled Directional Growth Response in Cardiomyocytes Circulation Research. 123. DOI: 10.1161/Res.123.Suppl_1.306  0.328
2018 Karch J, Molkentin JD. Identity of the elusive mitochondrial permeability transition pore: what it might be, what it was, and what it still could be Current Opinion in Physiology. 3: 57-62. DOI: 10.1016/J.Cophys.2018.03.001  0.319
2017 Sharp TE, Kubo H, Berretta RM, Starosta T, Wallner M, Schena GJ, Hobby AR, Yu D, Trappanese DM, George JC, Molkentin JD, Houser SR. Protein Kinase C Inhibition With Ruboxistaurin Increases Contractility and Reduces Heart Size in a Swine Model of Heart Failure With Reduced Ejection Fraction. Jacc. Basic to Translational Science. 2: 669-683. PMID 30062182 DOI: 10.1016/J.Jacbts.2017.06.007  0.416
2017 Li Y, Zhang X, Zhang C, Zhang X, Li Y, Qi Z, Szeto C, Tang M, Peng Y, Molkentin JD, Houser SR, Xie M, Chen X. Increasing T-Type calcium channel activity by β-adrenergic stimulation contributes to β-adrenergic regulation of heart rates. The Journal of Physiology. PMID 29274077 DOI: 10.1113/Jp274756  0.366
2017 Accornero F, Schips TG, Petrosino JM, Gu SQ, Kanisicak O, van Berlo JH, Molkentin JD. BEX1 is an RNA-dependent mediator of cardiomyopathy. Nature Communications. 8: 1875. PMID 29192139 DOI: 10.1038/S41467-017-02005-1  0.447
2017 Karch J, Schips TG, Maliken BD, Brody MJ, Sargent MA, Kanisciak O, Molkentin JD. Autophagic cell death is dependent on lysosomal membrane permeability through Bax and Bak. Elife. 6. PMID 29148970 DOI: 10.7554/Elife.30543  0.302
2017 Kanisicak O, Vagnozzi RJ, Molkentin JD. Identity Crisis for Regenerative Cardiac cKit(+) Cells. Circulation Research. 121: 1130-1132. PMID 29074532 DOI: 10.1161/Circresaha.117.311921  0.406
2017 Khalil H, Maillet M, Molkentin JD. Spatial Gene Profiling in the Ischemic Heart: Fibroblasts Put on Their SOX. Circulation. 136: 1410-1411. PMID 28993372 DOI: 10.1161/Circulationaha.117.030625  0.44
2017 Khalil H, Kanisicak O, Prasad V, Correll RN, Fu X, Schips T, Vagnozzi RJ, Liu R, Huynh T, Lee SJ, Karch J, Molkentin JD. Fibroblast-specific TGF-β-Smad2/3 signaling underlies cardiac fibrosis. The Journal of Clinical Investigation. PMID 28891814 DOI: 10.1172/Jci94753  0.408
2017 Travers JG, Kamal FA, Valiente-Alandi I, Nieman ML, Sargent MA, Lorenz JN, Molkentin JD, Blaxall BC. Pharmacological and Activated Fibroblast Targeting of Gβγ-GRK2 After Myocardial Ischemia Attenuates Heart Failure Progression. Journal of the American College of Cardiology. 70: 958-971. PMID 28818206 DOI: 10.1016/J.Jacc.2017.06.049  0.434
2017 Schwanekamp JA, Lorts A, Sargent MA, York AJ, Grimes KM, Fischesser DM, Gokey JJ, Whitsett JA, Conway SJ, Molkentin JD. TGFBI functions similar to periostin but is uniquely dispensable during cardiac injury. Plos One. 12: e0181945. PMID 28750100 DOI: 10.1371/Journal.Pone.0181945  0.48
2017 Correll RN, Lynch JM, Schips TG, Prasad V, York AJ, Sargent MA, Brochet DXP, Ma J, Molkentin JD. Mitsugumin 29 regulates t-tubule architecture in the failing heart. Scientific Reports. 7: 5328. PMID 28706255 DOI: 10.1038/S41598-017-05284-2  0.454
2017 Eschenhagen T, Bolli R, Braun T, Field LJ, Fleischmann BK, Frisén J, Giacca M, Hare JM, Houser SR, Lee RT, Marbán E, Martin JF, Molkentin JD, Murry CE, Riley PR, et al. Cardiomyocyte Regeneration: A Consensus Statement. Circulation. PMID 28684531 DOI: 10.1161/Circulationaha.117.029343  0.513
2017 McLendon PM, Davis G, Gulick J, Singh SR, Xu N, Salomonis N, Molkentin JD, Robbins J. An Unbiased High Throughput Screen to Identify Novel Effectors that Impact on Cardiomyocyte Aggregate Levels. Circulation Research. PMID 28655832 DOI: 10.1161/Circresaha.117.310945  0.352
2017 He L, Huang X, Kanisicak O, Li Y, Wang Y, Li Y, Pu W, Liu Q, Zhang H, Tian X, Zhao H, Liu X, Zhang S, Nie Y, Hu S, ... ... Molkentin JD, et al. Preexisting endothelial cells mediate cardiac neovascularization after injury. The Journal of Clinical Investigation. PMID 28650345 DOI: 10.1172/Jci93868  0.368
2017 Luongo TS, Lambert JP, Gross P, Nwokedi M, Lombardi AA, Shanmughapriya S, Carpenter AC, Kolmetzky D, Gao E, van Berlo JH, Tsai EJ, Molkentin JD, Chen X, Madesh M, Houser SR, et al. The mitochondrial Na(+)/Ca(2+) exchanger is essential for Ca(2+) homeostasis and viability. Nature. PMID 28445457 DOI: 10.1038/Nature22082  0.679
2017 Tallquist MD, Molkentin JD. Redefining the identity of cardiac fibroblasts. Nature Reviews. Cardiology. PMID 28436487 DOI: 10.1038/Nrcardio.2017.57  0.433
2017 Correll RN, Makarewich CA, Zhang H, Zhang C, Sargent MA, York AJ, Berretta RM, Chen X, Houser SR, Molkentin JD. Caveolae-localized L-type Ca2+ channels do not contribute to function or hypertrophic signalling in the mouse heart. Cardiovascular Research. PMID 28402392 DOI: 10.1093/Cvr/Cvx046  0.389
2017 Molkentin JD, Bugg D, Ghearing N, Dorn LE, Kim P, Sargent MA, Gunaje J, Otsu K, Davis JM. Fibroblast-Specific Genetic Manipulation of p38 MAPK in vivo Reveals its Central Regulatory Role in Fibrosis. Circulation. PMID 28356446 DOI: 10.1161/Circulationaha.116.026238  0.494
2017 Cai CL, Molkentin JD. The Elusive Progenitor Cell in Cardiac Regeneration: Slip Slidin' Away. Circulation Research. 120: 400-406. PMID 28104772 DOI: 10.1161/Circresaha.116.309710  0.371
2016 Kanisicak O, Molkentin JD. Applying Modern Transcriptomics to Interrogate the Human Cardiac Fibroblast. Jacc. Basic to Translational Science. 1: 603-605. PMID 30167545 DOI: 10.1016/J.Jacbts.2016.10.002  0.361
2016 Kim JH, Kim K, Kim I, Seong S, Jeong BC, Nam KI, Kim KK, Molkentin JD, Kim N. RCANs regulate the convergent roles of NFATc1 in bone homeostasis. Scientific Reports. 6: 38526. PMID 27917924 DOI: 10.1038/Srep38526  0.339
2016 Liu R, Khalil H, Lin SJ, Sargent MA, York AJ, Molkentin JD. Nemo-Like Kinase (NLK) Is a Pathological Signaling Effector in the Mouse Heart. Plos One. 11: e0164897. PMID 27764156 DOI: 10.1371/Journal.Pone.0164897  0.526
2016 Vanhoutte D, Schips TG, Kwong JQ, Davis J, Tjondrokoesoemo A, Brody MJ, Sargent MA, Kanisicak O, Yi H, Gao QQ, Rabinowitz JE, Volk T, McNally EM, Molkentin JD. Thrombospondin expression in myofibers stabilizes muscle membranes. Elife. 5. PMID 27669143 DOI: 10.7554/Elife.17589  0.332
2016 Liu R, Molkentin JD. Regulation of cardiac hypertrophy and remodeling through the dual-specificity MAPK phosphatases (DUSPs). Journal of Molecular and Cellular Cardiology. PMID 27575022 DOI: 10.1016/J.Yjmcc.2016.08.018  0.501
2016 Seidlmayer LK, Kuhn J, Berbner A, Arias-Loza P, Williams T, Kaspar M, Czolbe M, Kwong JQ, Molkentin JD, Heinze K, Dedkova EN, Ritter O. IP3 mediated SR-mitochondrial crosstalk influences ATP production via mitochondrial Ca2+ uptake through the mRyR1 in cardiac myocytes. Cardiovascular Research. PMID 27496868 DOI: 10.1093/Cvr/Cvw185  0.39
2016 Wallner M, Duran JM, Mohsin S, Troupes CD, Vanhoutte D, Borghetti G, Vagnozzi RJ, Gross P, Yu D, Trappanese DM, Kubo H, Toib A, Sharp TE, Harper SC, Volkert MA, ... ... Molkentin JD, et al. Acute Catecholamine Exposure Causes Reversible Myocyte Injury Without Cardiac Regeneration. Circulation Research. PMID 27461939 DOI: 10.1161/Circresaha.116.308687  0.402
2016 Kanisicak O, Khalil H, Ivey MJ, Karch J, Maliken BD, Correll RN, Brody MJ, J Lin SC, Aronow BJ, Tallquist MD, Molkentin JD. Genetic lineage tracing defines myofibroblast origin and function in the injured heart. Nature Communications. 7: 12260. PMID 27447449 DOI: 10.1038/Ncomms12260  0.459
2016 Liu R, van Berlo JH, York AJ, Maillet M, Vagnozzi RJ, Molkentin JD. DUSP8 Regulates Cardiac Ventricular Remodeling by Altering ERK1/2 Signaling. Circulation Research. PMID 27225478 DOI: 10.1161/Circresaha.115.308238  0.44
2016 Lamar KM, Bogdanovich S, Gardner BB, Gao QQ, Miller T, Earley JU, Hadhazy M, Vo AH, Wren L, Molkentin JD, McNally EM. Overexpression of Latent TGFβ Binding Protein 4 in Muscle Ameliorates Muscular Dystrophy through Myostatin and TGFβ. Plos Genetics. 12: e1006019. PMID 27148972 DOI: 10.1371/Journal.Pgen.1006019  0.384
2016 Davis J, Davis LC, Correll RN, Makarewich CA, Schwanekamp JA, Moussavi-Harami F, Wang D, York AJ, Wu H, Houser SR, Seidman CE, Seidman JG, Regnier M, Metzger JM, Wu JC, ... Molkentin JD, et al. A Tension-Based Model Distinguishes Hypertrophic versus Dilated Cardiomyopathy. Cell. PMID 27114035 DOI: 10.1016/J.Cell.2016.04.002  0.413
2016 Tjondrokoesoemo A, Schips TG, Sargent MA, Vanhoutte D, Kanisicak O, Prasad V, Lin SJ, Maillet M, Molkentin JD. Cathepsin S contributes to the pathogenesis of muscular dystrophy in mice. The Journal of Biological Chemistry. PMID 26966179 DOI: 10.1074/Jbc.M116.719054  0.398
2016 van Berlo JH, Molkentin JD. Most of the Dust Has Settled: cKit+ Progenitor Cells Are an Irrelevant Source of Cardiac Myocytes In Vivo. Circulation Research. 118: 17-9. PMID 26837741 DOI: 10.1161/Circresaha.115.307934  0.389
2016 Tjondrokoesoemo A, Schips T, Kanisicak O, Sargent MA, Molkentin JD. Genetic overexpression of Serpina3n attenuates muscular dystrophy in mice. Human Molecular Genetics. 25: 1192-202. PMID 26744329 DOI: 10.1093/Hmg/Ddw005  0.367
2016 Zhang X, Ai X, Nakayama H, Chen B, Harris DM, Tang M, Xie Y, Szeto C, Li Y, Li Y, Zhang H, Eckhart AD, Koch WJ, Molkentin JD, Chen X. Persistent increases in Ca(2+) influx through Cav1.2 shortens action potential and causes Ca(2+) overload-induced afterdepolarizations and arrhythmias. Basic Research in Cardiology. 111: 4. PMID 26611208 DOI: 10.1007/S00395-015-0523-4  0.378
2016 Schwanekamp JA, Lorts A, Vagnozzi RJ, Vanhoutte D, Molkentin JD. Deletion of Periostin Protects Against Atherosclerosis in Mice by Altering Inflammation and Extracellular Matrix Remodeling. Arteriosclerosis, Thrombosis, and Vascular Biology. 36: 60-8. PMID 26564821 DOI: 10.1161/Atvbaha.115.306397  0.328
2015 Lu X, Kwong J, Molkentin JD, Bers DM. Individual Cardiac Mitochondria Undergo Rare Transient Permeability Transition Pore Openings. Circulation Research. PMID 26712344 DOI: 10.1161/Circresaha.115.308093  0.338
2015 Davis J, Salomonis N, Ghearing N, Lin SC, Kwong JQ, Mohan A, Swanson MS, Molkentin JD. MBNL1-mediated regulation of differentiation RNAs promotes myofibroblast transformation and the fibrotic response. Nature Communications. 6: 10084. PMID 26670661 DOI: 10.1038/Ncomms10084  0.335
2015 Li L, Chen Y, Li J, Yin H, Guo X, Doan J, Molkentin JD, Liu Q. TAK1 Regulates Myocardial Response to Pathological Stress via NFAT, NFκB, and Bnip3 Pathways. Scientific Reports. 5: 16626. PMID 26564789 DOI: 10.1038/Srep16626  0.536
2015 Brody MJ, Schips TG, Vanhoutte D, Kanisicak O, Karch J, Maliken BD, Blair NS, Sargent MA, Prasad V, Molkentin JD. Dissection of thrombospondin-4 domains involved in intracellular adaptive ER Stress responsive signaling. Molecular and Cellular Biology. PMID 26459760 DOI: 10.1128/Mcb.00607-15  0.311
2015 Pfluger PT, Kabra DG, Aichler M, Schriever SC, Pfuhlmann K, García VC, Lehti M, Weber J, Kutschke M, Rozman J, Elrod JW, Hevener AL, Feuchtinger A, Hrabě de Angelis M, Walch A, ... ... Molkentin JD, et al. Calcineurin Links Mitochondrial Elongation with Energy Metabolism. Cell Metabolism. PMID 26411342 DOI: 10.1016/J.Cmet.2015.08.022  0.61
2015 Liu R, Correll RN, Davis J, Vagnozzi RJ, York AJ, Sargent MA, Nairn AC, Molkentin JD. Cardiac-specific deletion of protein phosphatase 1β promotes increased myofilament protein phosphorylation and contractile alterations. Journal of Molecular and Cellular Cardiology. 87: 204-13. PMID 26334248 DOI: 10.1016/J.Yjmcc.2015.08.018  0.478
2015 Correll RN, Goonasekera SA, van Berlo JH, Burr AR, Accornero F, Zhang H, Makarewich CA, York AJ, Sargent MA, Chen X, Houser SR, Molkentin JD. STIM1 elevation in the heart results in aberrant Ca(2+) handling and cardiomyopathy. Journal of Molecular and Cellular Cardiology. PMID 26241845 DOI: 10.1016/J.Yjmcc.2015.07.032  0.415
2015 Kwong JQ, Lu X, Correll RN, Schwanekamp JA, Vagnozzi RJ, Sargent MA, York AJ, Zhang J, Bers DM, Molkentin JD. The Mitochondrial Calcium Uniporter Selectively Matches Metabolic Output to Acute Contractile Stress in the Heart. Cell Reports. PMID 26119742 DOI: 10.1016/J.Celrep.2015.06.002  0.364
2015 Burr AR, Molkentin JD. Genetic evidence in the mouse solidifies the calcium hypothesis of myofiber death in muscular dystrophy. Cell Death and Differentiation. 22: 1402-12. PMID 26088163 DOI: 10.1038/Cdd.2015.65  0.303
2015 Shojaee S, Caeser R, Buchner M, Park E, Swaminathan S, Hurtz C, Geng H, Chan LN, Klemm L, Hofmann WK, Qiu YH, Zhang N, Coombes KR, Paietta E, Molkentin J, et al. Erk Negative Feedback Control Enables Pre-B Cell Transformation and Represents a Therapeutic Target in Acute Lymphoblastic Leukemia. Cancer Cell. 28: 114-28. PMID 26073130 DOI: 10.1016/J.Ccell.2015.05.008  0.317
2015 Karch J, Kanisicak O, Brody MJ, Sargent MA, Michael DM, Molkentin JD. Necroptosis Interfaces with MOMP and the MPTP in Mediating Cell Death. Plos One. 10: e0130520. PMID 26061004 DOI: 10.1371/Journal.Pone.0130520  0.344
2015 Karch J, Molkentin JD. Regulated necrotic cell death: the passive aggressive side of Bax and Bak. Circulation Research. 116: 1800-9. PMID 25999420 DOI: 10.1161/Circresaha.116.305421  0.319
2015 Jin S, Orabi AI, Le T, Javed TA, Sah S, Eisses JF, Bottino R, Molkentin JD, Husain SZ. Exposure to Radiocontrast Agents Induces Pancreatic Inflammation by Activation of Nuclear Factor-kB, Calcium Signaling, and Calcineurin. Gastroenterology. PMID 25980752 DOI: 10.1053/J.Gastro.2015.05.004  0.382
2015 Accornero F, van Berlo JH, Correll RN, Elrod JW, Sargent MA, York A, Rabinowitz JE, Leask A, Molkentin JD. Genetic Analysis of Connective Tissue Growth Factor as an Effector of Transforming Growth Factor β Signaling and Cardiac Remodeling. Molecular and Cellular Biology. 35: 2154-64. PMID 25870108 DOI: 10.1128/Mcb.00199-15  0.673
2015 Sopariwala DH, Pant M, Shaikh SA, Goonasekera SA, Molkentin JD, Weisleder N, Ma J, Pan Z, Periasamy M. Sarcolipin overexpression improves muscle energetics and reduces fatigue. Journal of Applied Physiology (Bethesda, Md. : 1985). 118: 1050-8. PMID 25701006 DOI: 10.1152/Japplphysiol.01066.2014  0.339
2015 Mázala DA, Pratt SJ, Chen D, Molkentin JD, Lovering RM, Chin ER. SERCA1 overexpression minimizes skeletal muscle damage in dystrophic mouse models. American Journal of Physiology. Cell Physiology. 308: C699-709. PMID 25652448 DOI: 10.1152/Ajpcell.00341.2014  0.39
2015 Kwong JQ, Molkentin JD. Physiological and pathological roles of the mitochondrial permeability transition pore in the heart. Cell Metabolism. 21: 206-14. PMID 25651175 DOI: 10.1016/J.Cmet.2014.12.001  0.36
2014 van Berlo JH, Molkentin JD. An emerging consensus on cardiac regeneration. Nature Medicine. 20: 1386-93. PMID 25473919 DOI: 10.1038/Nm.3764  0.395
2014 Ceco E, Bogdanovich S, Gardner B, Miller T, DeJesus A, Earley JU, Hadhazy M, Smith LR, Barton ER, Molkentin JD, McNally EM. Targeting latent TGFβ release in muscular dystrophy. Science Translational Medicine. 6: 259ra144. PMID 25338755 DOI: 10.1126/Scitranslmed.3010018  0.38
2014 Lauriol J, Keith K, Jaffré F, Couvillon A, Saci A, Goonasekera SA, McCarthy JR, Kessinger CW, Wang J, Ke Q, Kang PM, Molkentin JD, Carpenter C, Kontaridis MI. RhoA signaling in cardiomyocytes protects against stress-induced heart failure but facilitates cardiac fibrosis. Science Signaling. 7: ra100. PMID 25336613 DOI: 10.1126/Scisignal.2005262  0.526
2014 Li L, Chen Y, Doan J, Murray J, Molkentin JD, Liu Q. Transforming growth factor β-activated kinase 1 signaling pathway critically regulates myocardial survival and remodeling. Circulation. 130: 2162-72. PMID 25278099 DOI: 10.1161/Circulationaha.114.011195  0.435
2014 Molkentin JD. Letter by Molkentin regarding article, "The absence of evidence is not evidence of absence: the pitfalls of Cre Knock-Ins in the c-Kit Locus". Circulation Research. 115: e21-3. PMID 25258403 DOI: 10.1161/Circresaha.114.305011  0.373
2014 Accornero F, Kanisicak O, Tjondrokoesoemo A, Attia AC, McNally EM, Molkentin JD. Myofiber-specific inhibition of TGFβ signaling protects skeletal muscle from injury and dystrophic disease in mice. Human Molecular Genetics. 23: 6903-15. PMID 25106553 DOI: 10.1093/Hmg/Ddu413  0.406
2014 Gupta MK, Gulick J, Liu R, Wang X, Molkentin JD, Robbins J. Sumo E2 enzyme UBC9 is required for efficient protein quality control in cardiomyocytes. Circulation Research. 115: 721-9. PMID 25097219 DOI: 10.1161/Circresaha.115.304760  0.356
2014 Goldstein JA, Bogdanovich S, Beiriger A, Wren LM, Rossi AE, Gao QQ, Gardner BB, Earley JU, Molkentin JD, McNally EM. Excess SMAD signaling contributes to heart and muscle dysfunction in muscular dystrophy. Human Molecular Genetics. 23: 6722-31. PMID 25070948 DOI: 10.1093/Hmg/Ddu390  0.429
2014 Makarewich CA, Zhang H, Davis J, Correll RN, Trappanese DM, Hoffman NE, Troupes CD, Berretta RM, Kubo H, Madesh M, Chen X, Gao E, Molkentin JD, Houser SR. Transient receptor potential channels contribute to pathological structural and functional remodeling after myocardial infarction. Circulation Research. 115: 567-80. PMID 25047165 DOI: 10.1161/Circresaha.115.303831  0.416
2014 Wissing ER, Boyer JG, Kwong JQ, Sargent MA, Karch J, McNally EM, Otsu K, Molkentin JD. P38α MAPK underlies muscular dystrophy and myofiber death through a Bax-dependent mechanism. Human Molecular Genetics. 23: 5452-63. PMID 24876160 DOI: 10.1093/Hmg/Ddu270  0.422
2014 Tane S, Kubota M, Okayama H, Ikenishi A, Yoshitome S, Iwamoto N, Satoh Y, Kusakabe A, Ogawa S, Kanai A, Molkentin JD, Nakamura K, Ohbayashi T, Takeuchi T. Repression of cyclin D1 expression is necessary for the maintenance of cell cycle exit in adult mammalian cardiomyocytes. The Journal of Biological Chemistry. 289: 18033-44. PMID 24821722 DOI: 10.1074/Jbc.M113.541953  0.353
2014 van Berlo JH, Kanisicak O, Maillet M, Vagnozzi RJ, Karch J, Lin SC, Middleton RC, Marbán E, Molkentin JD. c-kit+ cells minimally contribute cardiomyocytes to the heart. Nature. 509: 337-41. PMID 24805242 DOI: 10.1038/Nature13309  0.423
2014 Gutiérrez-Aguilar M, Douglas DL, Gibson AK, Domeier TL, Molkentin JD, Baines CP. Genetic manipulation of the cardiac mitochondrial phosphate carrier does not affect permeability transition. Journal of Molecular and Cellular Cardiology. 72: 316-25. PMID 24768964 DOI: 10.1016/J.Yjmcc.2014.04.008  0.395
2014 Burr AR, Millay DP, Goonasekera SA, Park KH, Sargent MA, Collins J, Altamirano F, Philipson KD, Allen PD, Ma J, López JR, Molkentin JD. Na+ dysregulation coupled with Ca2+ entry through NCX1 promotes muscular dystrophy in mice. Molecular and Cellular Biology. 34: 1991-2002. PMID 24662047 DOI: 10.1128/Mcb.00339-14  0.35
2014 Kwong JQ, Davis J, Baines CP, Sargent MA, Karch J, Wang X, Huang T, Molkentin JD. Genetic deletion of the mitochondrial phosphate carrier desensitizes the mitochondrial permeability transition pore and causes cardiomyopathy Cell Death and Differentiation. 21: 1209-1217. PMID 24658400 DOI: 10.1038/Cdd.2014.36  0.447
2014 Rainer PP, Hao S, Vanhoutte D, Lee DI, Koitabashi N, Molkentin JD, Kass DA. Cardiomyocyte-specific transforming growth factor β suppression blocks neutrophil infiltration, augments multiple cytoprotective cascades, and reduces early mortality after myocardial infarction. Circulation Research. 114: 1246-57. PMID 24573206 DOI: 10.1161/Circresaha.114.302653  0.416
2014 Goonasekera SA, Davis J, Kwong JQ, Accornero F, Wei-LaPierre L, Sargent MA, Dirksen RT, Molkentin JD. Enhanced Ca²⁺ influx from STIM1-Orai1 induces muscle pathology in mouse models of muscular dystrophy. Human Molecular Genetics. 23: 3706-15. PMID 24556214 DOI: 10.1093/Hmg/Ddu079  0.388
2014 Molkentin JD, Houser SR. Response to Torella et al. Circulation Research. 114: e27. PMID 24526680 DOI: 10.1161/Circresaha.114.303361  0.327
2014 Correll RN, Eder P, Burr AR, Despa S, Davis J, Bers DM, Molkentin JD. Overexpression of the Na+/K+ ATPase α2 but not α1 isoform attenuates pathological cardiac hypertrophy and remodeling. Circulation Research. 114: 249-56. PMID 24218169 DOI: 10.1161/Circresaha.114.302293  0.399
2014 Davis J, Molkentin JD. Myofibroblasts: trust your heart and let fate decide. Journal of Molecular and Cellular Cardiology. 70: 9-18. PMID 24189039 DOI: 10.1016/J.Yjmcc.2013.10.019  0.47
2013 van Berlo JH, Aronow BJ, Molkentin JD. Parsing the roles of the transcription factors GATA-4 and GATA-6 in the adult cardiac hypertrophic response. Plos One. 8: e84591. PMID 24391969 DOI: 10.1371/Journal.Pone.0084591  0.473
2013 Davis J, Kwong JQ, Kitsis RN, Molkentin JD. Apoptosis repressor with a CARD domain (ARC) restrains Bax-mediated pathogenesis in dystrophic skeletal muscle. Plos One. 8: e82053. PMID 24312627 DOI: 10.1371/Journal.Pone.0082053  0.384
2013 Braitsch CM, Kanisicak O, van Berlo JH, Molkentin JD, Yutzey KE. Differential expression of embryonic epicardial progenitor markers and localization of cardiac fibrosis in adult ischemic injury and hypertensive heart disease. Journal of Molecular and Cellular Cardiology. 65: 108-19. PMID 24140724 DOI: 10.1016/J.Yjmcc.2013.10.005  0.456
2013 Molkentin JD, Houser SR. Are resident c-Kit+ cardiac stem cells really all that are needed to mend a broken heart? Circulation Research. 113: 1037-9. PMID 24115067 DOI: 10.1161/Circresaha.113.302564  0.413
2013 Karch J, Kwong JQ, Burr AR, Sargent MA, Elrod JW, Peixoto PM, Martinez-Caballero S, Osinska H, Cheng EH, Robbins J, Kinnally KW, Molkentin JD. Bax and Bak function as the outer membrane component of the mitochondrial permeability pore in regulating necrotic cell death in mice. Elife. 2: e00772. PMID 23991283 DOI: 10.7554/Elife.00772  0.589
2013 Molkentin JD. Parsing good versus bad signaling pathways in the heart: role of calcineurin-nuclear factor of activated T-cells. Circulation Research. 113: 16-9. PMID 23788503 DOI: 10.1161/Circresaha.113.301667  0.45
2013 Correll RN, Molkentin JD. CaMKII does it again: even the mitochondria cannot escape its influence. Circulation Research. 112: 1208-11. PMID 23620234 DOI: 10.1161/Circresaha.113.301263  0.36
2013 Elrod JW, Molkentin JD. Physiologic functions of cyclophilin D and the mitochondrial permeability transition pore. Circulation Journal : Official Journal of the Japanese Circulation Society. 77: 1111-22. PMID 23538482 DOI: 10.1253/Circj.Cj-13-0321  0.596
2013 Nicholson CK, Lambert JP, Molkentin JD, Sadoshima J, Calvert JW. Thioredoxin 1 is essential for sodium sulfide-mediated cardioprotection in the setting of heart failure. Arteriosclerosis, Thrombosis, and Vascular Biology. 33: 744-51. PMID 23349187 DOI: 10.1161/Atvbaha.112.300484  0.344
2013 van Berlo JH, Maillet M, Molkentin JD. Signaling effectors underlying pathologic growth and remodeling of the heart. The Journal of Clinical Investigation. 123: 37-45. PMID 23281408 DOI: 10.1172/Jci62839  0.447
2013 Suk HY, Zhou C, Yang TT, Zhu H, Yu RY, Olabisi O, Yang X, Brancho D, Kim JY, Scherer PE, Frank PG, Lisanti MP, Calvert JW, Lefer DJ, Molkentin JD, et al. Ablation of calcineurin Aβ reveals hyperlipidemia and signaling cross-talks with phosphodiesterases. The Journal of Biological Chemistry. 288: 3477-88. PMID 23258544 DOI: 10.1074/Jbc.M112.419150  0.582
2013 Maillet M, van Berlo JH, Molkentin JD. Molecular basis of physiological heart growth: fundamental concepts and new players. Nature Reviews. Molecular Cell Biology. 14: 38-48. PMID 23258295 DOI: 10.1038/Nrm3495  0.443
2013 Muili KA, Wang D, Orabi AI, Sarwar S, Luo Y, Javed TA, Eisses JF, Mahmood SM, Jin S, Singh VP, Ananthanaravanan M, Perides G, Williams JA, Molkentin JD, Husain SZ. Bile acids induce pancreatic acinar cell injury and pancreatitis by activating calcineurin. The Journal of Biological Chemistry. 288: 570-80. PMID 23148215 DOI: 10.1074/Jbc.M112.428896  0.325
2013 Auger-Messier M, Accornero F, Goonasekera SA, Bueno OF, Lorenz JN, van Berlo JH, Willette RN, Molkentin JD. Unrestrained p38 MAPK activation in Dusp1/4 double-null mice induces cardiomyopathy. Circulation Research. 112: 48-56. PMID 22993413 DOI: 10.1161/Circresaha.112.272963  0.453
2013 Karch J, Kwong JQ, Burr AR, Sargent MA, Elrod JW, Peixoto PM, Martinez-Caballero S, Osinska H, Cheng EH, Robbins J, Kinnally KW, Molkentin JD. Author response: Bax and Bak function as the outer membrane component of the mitochondrial permeability pore in regulating necrotic cell death in mice Elife. DOI: 10.7554/Elife.00772.020  0.61
2013 Auger-Messier M, Accornero F, Goonasekera SA, Bueno OF, Lorenz JN, Berlo Jv, Willette RN, Molkentin JD. Erratum: Unrestrained p38 MAPK activation in Dusp1/4 double-null mice induces cardiomyopathy (Circulation Research (2013) 112 (48-56) DOI: 10.1161/CIRCRESAHA.112.272963) Circulation Research. 112. DOI: 10.1161/Res.0B013E318286C253  0.346
2012 Drawnel FM, Wachten D, Molkentin JD, Maillet M, Aronsen JM, Swift F, Sjaastad I, Liu N, Catalucci D, Mikoshiba K, Hisatsune C, Okkenhaug H, Andrews SR, Bootman MD, Roderick HL. Mutual antagonism between IP(3)RII and miRNA-133a regulates calcium signals and cardiac hypertrophy. The Journal of Cell Biology. 199: 783-98. PMID 23166348 DOI: 10.1085/Jgp1411Oia1  0.312
2012 Schulz EM, Correll RN, Sheikh HN, Lofrano-Alves MS, Engel PL, Newman G, Schultz JEJ, Molkentin JD, Wolska BM, Solaro RJ, Wieczorek DF. Tropomyosin dephosphorylation results in compensated cardiac hypertrophy Journal of Biological Chemistry. 287: 44478-44489. PMID 23148217 DOI: 10.1074/Jbc.M112.402040  0.474
2012 Bolte C, Zhang Y, York A, Kalin TV, Schultz Jel J, Molkentin JD, Kalinichenko VV. Postnatal ablation of Foxm1 from cardiomyocytes causes late onset cardiac hypertrophy and fibrosis without exacerbating pressure overload-induced cardiac remodeling. Plos One. 7: e48713. PMID 23144938 DOI: 10.1371/Journal.Pone.0048713  0.491
2012 Karch J, Molkentin JD. Is p53 the long-sought molecular trigger for cyclophilin D-regulated mitochondrial permeability transition pore formation and necrosis? Circulation Research. 111: 1258-60. PMID 23104876 DOI: 10.1161/Circresaha.112.280990  0.365
2012 Davis J, Burr AR, Davis GF, Birnbaumer L, Molkentin JD. A TRPC6-dependent pathway for myofibroblast transdifferentiation and wound healing in vivo. Developmental Cell. 23: 705-15. PMID 23022034 DOI: 10.1016/J.Devcel.2012.08.017  0.398
2012 Bal NC, Maurya SK, Sopariwala DH, Sahoo SK, Gupta SC, Shaikh SA, Pant M, Rowland LA, Bombardier E, Goonasekera SA, Tupling AR, Molkentin JD, Periasamy M. Sarcolipin is a newly identified regulator of muscle-based thermogenesis in mammals. Nature Medicine. 18: 1575-9. PMID 22961106 DOI: 10.1038/Nm.2897  0.366
2012 Davis J, Maillet M, Miano JM, Molkentin JD. Lost in transgenesis: a user's guide for genetically manipulating the mouse in cardiac research. Circulation Research. 111: 761-77. PMID 22935533 DOI: 10.1161/Circresaha.111.262717  0.4
2012 Gao H, Wang F, Wang W, Makarewich CA, Zhang H, Kubo H, Berretta RM, Barr LA, Molkentin JD, Houser SR. Ca(2+) influx through L-type Ca(2+) channels and transient receptor potential channels activates pathological hypertrophy signaling. Journal of Molecular and Cellular Cardiology. 53: 657-67. PMID 22921230 DOI: 10.1016/J.Yjmcc.2012.08.005  0.339
2012 Maejima Y, Galeotti J, Molkentin JD, Sadoshima J, Zhai P. Constitutively active MEK1 rescues cardiac dysfunction caused by overexpressed GSK-3α during aging and hemodynamic pressure overload. American Journal of Physiology. Heart and Circulatory Physiology. 303: H979-88. PMID 22904158 DOI: 10.1152/Ajpheart.00415.2012  0.451
2012 Lorts A, Schwanekamp JA, Baudino TA, McNally EM, Molkentin JD. Deletion of periostin reduces muscular dystrophy and fibrosis in mice by modulating the transforming growth factor-β pathway. Proceedings of the National Academy of Sciences of the United States of America. 109: 10978-83. PMID 22711826 DOI: 10.1073/Pnas.1204708109  0.364
2012 Lynch JM, Maillet M, Vanhoutte D, Schloemer A, Sargent MA, Blair NS, Lynch KA, Okada T, Aronow BJ, Osinska H, Prywes R, Lorenz JN, Mori K, Lawler J, Robbins J, ... Molkentin JD, et al. A thrombospondin-dependent pathway for a protective ER stress response. Cell. 149: 1257-68. PMID 22682248 DOI: 10.1016/J.Cell.2012.03.050  0.392
2012 Houser SR, Margulies KB, Murphy AM, Spinale FG, Francis GS, Prabhu SD, Rockman HA, Kass DA, Molkentin JD, Sussman MA, Koch WJ, Koch W. Animal models of heart failure: a scientific statement from the American Heart Association. Circulation Research. 111: 131-50. PMID 22595296 DOI: 10.1161/Res.0B013E3182582523  0.314
2012 Liu Q, Chen Y, Auger-Messier M, Molkentin JD. Interaction between NFκB and NFAT coordinates cardiac hypertrophy and pathological remodeling. Circulation Research. 110: 1077-86. PMID 22403241 DOI: 10.1161/Circresaha.111.260729  0.439
2012 Muili KA, Ahmad M, Orabi AI, Mahmood SM, Shah AU, Molkentin JD, Husain SZ. Pharmacological and genetic inhibition of calcineurin protects against carbachol-induced pathological zymogen activation and acinar cell injury. American Journal of Physiology. Gastrointestinal and Liver Physiology. 302: G898-905. PMID 22323127 DOI: 10.1152/Ajpgi.00545.2011  0.358
2012 Makarewich CA, Correll RN, Gao H, Zhang H, Yang B, Berretta RM, Rizzo V, Molkentin JD, Houser SR. A caveolae-targeted L-type Ca²+ channel antagonist inhibits hypertrophic signaling without reducing cardiac contractility. Circulation Research. 110: 669-74. PMID 22302787 DOI: 10.1161/Circresaha.111.264028  0.367
2012 Goonasekera SA, Hammer K, Auger-Messier M, Bodi I, Chen X, Zhang H, Reiken S, Elrod JW, Correll RN, York AJ, Sargent MA, Hofmann F, Moosmang S, Marks AR, Houser SR, ... ... Molkentin JD, et al. Decreased cardiac L-type Ca²⁺ channel activity induces hypertrophy and heart failure in mice. The Journal of Clinical Investigation. 122: 280-90. PMID 22133878 DOI: 10.1172/Jci58227  0.693
2012 Goonasekera SA, Molkentin JD. Unraveling the secrets of a double life: contractile versus signaling Ca2+ in a cardiac myocyte. Journal of Molecular and Cellular Cardiology. 52: 317-22. PMID 21600216 DOI: 10.1016/J.Yjmcc.2011.05.001  0.394
2012 Shojaee S, Buchner M, Swaminathan S, Geng H, Chan L, Bothe M, Chen Z, Melnick A, Molkentin J, Martin G, Koeffler HP, Muschen M. Negative Feedback Signaling Enables Leukemic Transformation by Oncogenic Tyrosine Kinases Blood. 120: 1352-1352. DOI: 10.1182/Blood.V120.21.1352.1352  0.376
2012 Shojaee S, Buchner M, Swaminathan S, Chan L, Bothe M, Geng H, Melnick A, Molkentin J, Martin G, Koeffler P, Muschen M. Abstract 2944: Targeting negative feedback signaling in tyrosine kinase-driven malignancies Cancer Research. 72: 2944-2944. DOI: 10.1158/1538-7445.Am2012-2944  0.372
2012 Bal NC, Maurya SK, Sopariwala DH, Sahoo SK, Gupta SC, Shaikh SA, Pant M, Rowland LA, Goonasekera SA, Molkentin JD, Periasamy M. Erratum: Corrigendum: Sarcolipin is a newly identified regulator of muscle-based thermogenesis in mammals Nature Medicine. 18: 1857-1857. DOI: 10.1038/Nm1212-1857B  0.309
2011 Accornero F, Molkentin JD. Placental growth factor as a protective paracrine effector in the heart. Trends in Cardiovascular Medicine. 21: 220-4. PMID 22902069 DOI: 10.1016/J.Tcm.2012.05.014  0.435
2011 Ladage D, Tilemann L, Ishikawa K, Correll RN, Kawase Y, Houser SR, Molkentin JD, Hajjar RJ. Inhibition of PKCα/β with ruboxistaurin antagonizes heart failure in pigs after myocardial infarction injury. Circulation Research. 109: 1396-400. PMID 21998327 DOI: 10.1161/Circresaha.111.255687  0.461
2011 Hom JR, Quintanilla RA, Hoffman DL, de Mesy Bentley KL, Molkentin JD, Sheu SS, Porter GA. The permeability transition pore controls cardiac mitochondrial maturation and myocyte differentiation. Developmental Cell. 21: 469-78. PMID 21920313 DOI: 10.1016/J.Devcel.2011.08.008  0.348
2011 Xiang SY, Vanhoutte D, Del Re DP, Purcell NH, Ling H, Banerjee I, Bossuyt J, Lang RA, Zheng Y, Matkovich SJ, Miyamoto S, Molkentin JD, Dorn GW, Brown JH. RhoA protects the mouse heart against ischemia/reperfusion injury. The Journal of Clinical Investigation. 121: 3269-76. PMID 21747165 DOI: 10.1172/Jci44371  0.419
2011 van Berlo JH, Elrod JW, Aronow BJ, Pu WT, Molkentin JD. Serine 105 phosphorylation of transcription factor GATA4 is necessary for stress-induced cardiac hypertrophy in vivo. Proceedings of the National Academy of Sciences of the United States of America. 108: 12331-6. PMID 21746915 DOI: 10.1073/Pnas.1104499108  0.722
2011 Qian L, Wythe JD, Liu J, Cartry J, Vogler G, Mohapatra B, Otway RT, Huang Y, King IN, Maillet M, Zheng Y, Crawley T, Taghli-Lamallem O, Semsarian C, Dunwoodie S, ... ... Molkentin JD, et al. Tinman/Nkx2-5 acts via miR-1 and upstream of Cdc42 to regulate heart function across species. The Journal of Cell Biology. 193: 1181-96. PMID 21690310 DOI: 10.1083/Jcb.201006114  0.611
2011 Accornero F, Van Berlo JH, Benard MJ, Lorenz JN, Carmeliet P, Molkentin JD. Placental growth factor regulates cardiac adaptation and hypertrophy through a paracrine mechanism Circulation Research. 109: 272-280. PMID 21636802 DOI: 10.1161/Circresaha.111.240820  0.43
2011 Stefater JA, Lewkowich I, Rao S, Mariggi G, Carpenter AC, Burr AR, Fan J, Ajima R, Molkentin JD, Williams BO, Wills-Karp M, Pollard JW, Yamaguchi T, Ferrara N, Gerhardt H, et al. Regulation of angiogenesis by a non-canonical Wnt-Flt1 pathway in myeloid cells. Nature. 474: 511-5. PMID 21623369 DOI: 10.1038/Nature10085  0.301
2011 Sadayappan S, Gulick J, Osinska H, Barefield D, Cuello F, Avkiran M, Lasko VM, Lorenz JN, Maillet M, Martin JL, Brown JH, Bers DM, Molkentin JD, James J, Robbins J. A critical function for Ser-282 in cardiac Myosin binding protein-C phosphorylation and cardiac function. Circulation Research. 109: 141-50. PMID 21597010 DOI: 10.1161/Circresaha.111.242560  0.366
2011 Kehat I, Accornero F, Aronow BJ, Molkentin JD. Modulation of chromatin position and gene expression by HDAC4 interaction with nucleoporins. The Journal of Cell Biology. 193: 21-9. PMID 21464227 DOI: 10.1083/Jcb.201101046  0.349
2011 Breitbart A, Auger-Messier M, Molkentin JD, Heineke J. Myostatin from the heart: local and systemic actions in cardiac failure and muscle wasting. American Journal of Physiology. Heart and Circulatory Physiology. 300: H1973-82. PMID 21421824 DOI: 10.1152/Ajpheart.00200.2011  0.443
2011 Yamaguchi N, Chakraborty A, Pasek DA, Molkentin JD, Meissner G. Dysfunctional ryanodine receptor and cardiac hypertrophy: role of signaling molecules. American Journal of Physiology. Heart and Circulatory Physiology. 300: H2187-95. PMID 21421818 DOI: 10.1152/Ajpheart.00719.2010  0.404
2011 Ch'en IL, Tsau JS, Molkentin JD, Komatsu M, Hedrick SM. Mechanisms of necroptosis in T cells. The Journal of Experimental Medicine. 208: 633-41. PMID 21402742 DOI: 10.1084/Jem.20110251  0.328
2011 Meissner M, Weissgerber P, Londoño JE, Prenen J, Link S, Ruppenthal S, Molkentin JD, Lipp P, Nilius B, Freichel M, Flockerzi V. Moderate calcium channel dysfunction in adult mice with inducible cardiomyocyte-specific excision of the cacnb2 gene. The Journal of Biological Chemistry. 286: 15875-82. PMID 21357697 DOI: 10.1074/Jbc.M111.227819  0.405
2011 Molkentin JD. The transcription factor C/EBPbeta serves as a master regulator of physiologic cardiac hypertrophy. Circulation Research. 108: 277-8. PMID 21293006 DOI: 10.1161/Res.0B013E31820Ff484  0.407
2011 Goonasekera SA, Lam CK, Millay DP, Sargent MA, Hajjar RJ, Kranias EG, Molkentin JD. Mitigation of muscular dystrophy in mice by SERCA overexpression in skeletal muscle. The Journal of Clinical Investigation. 121: 1044-52. PMID 21285509 DOI: 10.1172/Jci43844  0.383
2011 Korf-Klingebiel M, Kempf T, Schlüter KD, Willenbockel C, Brod T, Heineke J, Schmidt VJ, Jantzen F, Brandes RP, Sugden PH, Drexler H, Molkentin JD, Wollert KC. Conditional transgenic expression of fibroblast growth factor 9 in the adult mouse heart reduces heart failure mortality after myocardial infarction. Circulation. 123: 504-14. PMID 21262993 DOI: 10.1161/Circulationaha.110.989665  0.432
2011 Eder P, Molkentin JD. TRPC channels as effectors of cardiac hypertrophy. Circulation Research. 108: 265-72. PMID 21252153 DOI: 10.1161/Circresaha.110.225888  0.412
2011 Bolli R, Stein AB, Guo Y, Wang OL, Rokosh G, Dawn B, Molkentin JD, Sanganalmath SK, Zhu Y, Xuan YT. A murine model of inducible, cardiac-specific deletion of STAT3: its use to determine the role of STAT3 in the upregulation of cardioprotective proteins by ischemic preconditioning. Journal of Molecular and Cellular Cardiology. 50: 589-97. PMID 21223971 DOI: 10.1016/J.Yjmcc.2011.01.002  0.455
2011 Sengupta A, Molkentin JD, Paik JH, DePinho RA, Yutzey KE. FoxO transcription factors promote cardiomyocyte survival upon induction of oxidative stress. The Journal of Biological Chemistry. 286: 7468-78. PMID 21159781 DOI: 10.1074/Jbc.M110.179242  0.397
2011 Kehat I, Davis J, Tiburcy M, Accornero F, Saba-El-Leil MK, Maillet M, York AJ, Lorenz JN, Zimmermann WH, Meloche S, Molkentin JD. Extracellular signal-regulated kinases 1 and 2 regulate the balance between eccentric and concentric cardiac growth. Circulation Research. 108: 176-83. PMID 21127295 DOI: 10.1161/Circresaha.110.231514  0.418
2011 Chen X, Nakayama H, Zhang X, Ai X, Harris DM, Tang M, Zhang H, Szeto C, Stockbower K, Berretta RM, Eckhart AD, Koch WJ, Molkentin JD, Houser SR. Calcium influx through Cav1.2 is a proximal signal for pathological cardiomyocyte hypertrophy. Journal of Molecular and Cellular Cardiology. 50: 460-70. PMID 21111744 DOI: 10.1016/J.Yjmcc.2010.11.012  0.347
2011 Sugden PH, Markou T, Fuller SJ, Tham el L, Molkentin JD, Paterson HF, Clerk A. Monophosphothreonyl extracellular signal-regulated kinases 1 and 2 (ERK1/2) are formed endogenously in intact cardiac myocytes and are enzymically active. Cellular Signalling. 23: 468-77. PMID 21044683 DOI: 10.1016/J.Cellsig.2010.10.024  0.346
2011 Wansapura JP, Millay DP, Dunn RS, Molkentin JD, Benson DW. Magnetic resonance imaging assessment of cardiac dysfunction in δ-sarcoglycan null mice. Neuromuscular Disorders : Nmd. 21: 68-73. PMID 20934875 DOI: 10.1016/J.Nmd.2010.09.007  0.35
2011 Reddy RN, Knotts TL, Roberts BR, Molkentin JD, Price SR, Gooch JL. Calcineurin A-β is required for hypertrophy but not matrix expansion in the diabetic kidney. Journal of Cellular and Molecular Medicine. 15: 414-22. PMID 19778355 DOI: 10.1111/J.1582-4934.2009.00910.X  0.313
2011 Shojaee S, Buchner M, Geng H, Melnick A, Gery S, Molkentin J, Koeffler P, Muschen M. DUSP6-Mediated Negative Feedback to Oncogenic Tyrosine Kinase Signaling Prevents Excessive Accumulation of ROS and Enables Leukemia Cell Survival Blood. 118: 1479-1479. DOI: 10.1182/Blood.V118.21.1479.1479  0.347
2011 Hom JR, Quintanilla RA, Hoffman DL, Bentley K, Molkentin JD, Sheu S, Porter GA. The Embryonic Mitochondrial Permeability Transition Pore Controls Cardiac Myocyte Mitochondrial Maturation and Differentiation Biophysical Journal. 100: 46a-47a. DOI: 10.1016/J.Bpj.2010.12.452  0.349
2011 Li Y, Wang F, Zhang X, Qi Z, Szeto C, Tang M, Guan Y, Ai X, Zhang H, Molkentin JD, Chen X. Cav3.1/α1G T-Type Ca2+ Channels are Involved in the Heart Rate Regulation Biophysical Journal. 100: 567a. DOI: 10.1016/J.Bpj.2010.12.3288  0.383
2010 Marber MS, Molkentin JD, Force T. Developing small molecules to inhibit kinases unkind to the heart: p38 MAPK as a case in point. Drug Discovery Today. Disease Mechanisms. 7: e123-e127. PMID 21278838 DOI: 10.1016/J.Ddmec.2010.07.006  0.395
2010 Kehat I, Molkentin JD. Molecular pathways underlying cardiac remodeling during pathophysiological stimulation. Circulation. 122: 2727-35. PMID 21173361 DOI: 10.1161/Circulationaha.110.942268  0.442
2010 Liu Q, Molkentin JD. Protein kinase Cα as a heart failure therapeutic target. Journal of Molecular and Cellular Cardiology. 51: 474-8. PMID 20937286 DOI: 10.1016/J.Yjmcc.2010.10.004  0.401
2010 Elrod JW, Wong R, Mishra S, Vagnozzi RJ, Sakthievel B, Goonasekera SA, Karch J, Gabel S, Farber J, Force T, Brown JH, Murphy E, Molkentin JD. Cyclophilin D controls mitochondrial pore-dependent Ca(2+) exchange, metabolic flexibility, and propensity for heart failure in mice. The Journal of Clinical Investigation. 120: 3680-7. PMID 20890047 DOI: 10.1172/Jci43171  0.676
2010 Force T, Bonow RO, Houser SR, Solaro RJ, Hershberger RE, Adhikari B, Anderson ME, Boineau R, Byrne BJ, Cappola TP, Kalluri R, LeWinter MM, Maron MS, Molkentin JD, Ommen SR, et al. Research priorities in hypertrophic cardiomyopathy: report of a Working Group of the National Heart, Lung, and Blood Institute. Circulation. 122: 1130-3. PMID 20837938 DOI: 10.1161/Circulationaha.110.950089  0.39
2010 Sun T, Wu XS, Xu J, McNeil BD, Pang ZP, Yang W, Bai L, Qadri S, Molkentin JD, Yue DT, Wu LG. The role of calcium/calmodulin-activated calcineurin in rapid and slow endocytosis at central synapses. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 11838-47. PMID 20810903 DOI: 10.1523/Jneurosci.1481-10.2010  0.308
2010 van Berlo JH, Elrod JW, van den Hoogenhof MM, York AJ, Aronow BJ, Duncan SA, Molkentin JD. The transcription factor GATA-6 regulates pathological cardiac hypertrophy. Circulation Research. 107: 1032-40. PMID 20705924 DOI: 10.1161/Circresaha.110.220764  0.65
2010 Zhang H, Chen X, Gao E, MacDonnell SM, Wang W, Kolpakov M, Nakayama H, Zhang X, Jaleel N, Harris DM, Li Y, Tang M, Berretta R, Leri A, Kajstura J, ... ... Molkentin JD, et al. Increasing cardiac contractility after myocardial infarction exacerbates cardiac injury and pump dysfunction Circulation Research. 107: 800-809. PMID 20671241 DOI: 10.1016/J.Bpj.2008.12.1276  0.394
2010 Heineke J, Auger-Messier M, Correll RN, Xu J, Benard MJ, Yuan W, Drexler H, Parise LV, Molkentin JD. CIB1 is a regulator of pathological cardiac hypertrophy Nature Medicine. 16: 872-879. PMID 20639889 DOI: 10.1038/Nm.2181  0.513
2010 Wissing ER, Millay DP, Vuagniaux G, Molkentin JD. Debio-025 is more effective than prednisone in reducing muscular pathology in mdx mice. Neuromuscular Disorders : Nmd. 20: 753-60. PMID 20637615 DOI: 10.1016/J.Nmd.2010.06.016  0.372
2010 Nakayama H, Bodi I, Maillet M, DeSantiago J, Domeier TL, Mikoshiba K, Lorenz JN, Blatter LA, Bers DM, Molkentin JD. The IP3 receptor regulates cardiac hypertrophy in response to select stimuli. Circulation Research. 107: 659-66. PMID 20616315 DOI: 10.1161/Circresaha.110.220038  0.468
2010 Tang M, Li J, Huang W, Su H, Liang Q, Tian Z, Horak KM, Molkentin JD, Wang X. Proteasome functional insufficiency activates the calcineurin-NFAT pathway in cardiomyocytes and promotes maladaptive remodelling of stressed mouse hearts. Cardiovascular Research. 88: 424-33. PMID 20601385 DOI: 10.1093/Cvr/Cvq217  0.473
2010 Tang M, Zhang X, Li Y, Guan Y, Ai X, Szeto C, Nakayama H, Zhang H, Ge S, Molkentin JD, Houser SR, Chen X. Enhanced basal contractility but reduced excitation-contraction coupling efficiency and beta-adrenergic reserve of hearts with increased Cav1.2 activity. American Journal of Physiology. Heart and Circulatory Physiology. 299: H519-28. PMID 20543081 DOI: 10.1152/Ajpheart.00265.2010  0.42
2010 Gilio K, Harper MT, Cosemans JM, Konopatskaya O, Munnix IC, Prinzen L, Leitges M, Liu Q, Molkentin JD, Heemskerk JW, Poole AW. Functional divergence of platelet protein kinase C (PKC) isoforms in thrombus formation on collagen. The Journal of Biological Chemistry. 285: 23410-9. PMID 20479008 DOI: 10.1074/Jbc.M110.136176  0.315
2010 Kitsis RN, Molkentin JD. Apoptotic cell death "Nixed" by an ER-mitochondrial necrotic pathway. Proceedings of the National Academy of Sciences of the United States of America. 107: 9031-2. PMID 20448198 DOI: 10.1073/Pnas.1003827107  0.317
2010 Wu X, Eder P, Chang B, Molkentin JD. TRPC channels are necessary mediators of pathologic cardiac hypertrophy Proceedings of the National Academy of Sciences of the United States of America. 107: 7000-7005. PMID 20351294 DOI: 10.1073/Pnas.1001825107  0.488
2010 Rinne A, Kapur N, Molkentin JD, Pogwizd SM, Bers DM, Banach K, Blatter LA. Isoform- and tissue-specific regulation of the Ca2+-sensitive transcription factor NFAT in cardiac myocytes and heart failure American Journal of Physiology - Heart and Circulatory Physiology. 298: H2001-H2009. PMID 20304816 DOI: 10.1152/Ajpheart.01072.2009  0.45
2010 Kehat I, Molkentin JD. Extracellular signal-regulated kinase 1/2 (ERK1/2) signaling in cardiac hypertrophy. Annals of the New York Academy of Sciences. 1188: 96-102. PMID 20201891 DOI: 10.1111/J.1749-6632.2009.05088.X  0.498
2010 Tsika RW, Ma L, Kehat I, Schramm C, Simmer G, Morgan B, Fine DM, Hanft LM, McDonald KS, Molkentin JD, Krenz M, Yang S, Ji J. TEAD-1 overexpression in the mouse heart promotes an age-dependent heart dysfunction. The Journal of Biological Chemistry. 285: 13721-35. PMID 20194497 DOI: 10.1074/Jbc.M109.063057  0.502
2010 Heineke J, Auger-Messier M, Xu J, Sargent M, York A, Welle S, Molkentin JD. Genetic deletion of myostatin from the heart prevents skeletal muscle atrophy in heart failure. Circulation. 121: 419-25. PMID 20065166 DOI: 10.1161/Circulationaha.109.882068  0.414
2010 Maillet M, Davis J, Auger-Messier M, York A, Osinska H, Piquereau J, Lorenz JN, Robbins J, Ventura-Clapier R, Molkentin JD. Heart-specific deletion of CnB1 reveals multiple mechanisms whereby calcineurin regulates cardiac growth and function. The Journal of Biological Chemistry. 285: 6716-24. PMID 20037164 DOI: 10.1074/Jbc.M109.056143  0.529
2010 Quinsay MN, Lee Y, Rikka S, Sayen MR, Molkentin JD, Gottlieb RA, Gustafsson AB. Bnip3 mediates permeabilization of mitochondria and release of cytochrome c via a novel mechanism. Journal of Molecular and Cellular Cardiology. 48: 1146-56. PMID 20025887 DOI: 10.1016/J.Yjmcc.2009.12.004  0.33
2010 Heineke J, Wollert KC, Osinska H, Sargent MA, York AJ, Robbins J, Molkentin JD. Calcineurin protects the heart in a murine model of dilated cardiomyopathy. Journal of Molecular and Cellular Cardiology. 48: 1080-7. PMID 19854199 DOI: 10.1016/J.Yjmcc.2009.10.012  0.502
2010 Teekakirikul P, Eminaga S, Toka O, Wang L, Wakimoto H, Nayor M, Konno T, Wolf CM, Alcalai R, Gorham J, Schmitt JP, Caine B, Markwald RR, Hoffman SR, Molkentin JD, et al. INHIBITION OF CARDIAC FIBROSIS MEDIATED BY NON-MYOCYTE PROLIFERATION IN HYPERTROPHIC CARDIOMYOPATHY Journal of the American College of Cardiology. 55: A21.E199. DOI: 10.1016/S0735-1097(10)60200-8  0.409
2010 Eder P, Wu X, Molkentin JD. Effects of Cardiac Specific Inhibition of TRPC Channels on Cardiac Hypertrophy and Ca2+ Handling Biophysical Journal. 98: 344a. DOI: 10.1016/J.Bpj.2009.12.1861  0.43
2009 Nakayama H, Bodi I, Correll RN, Chen X, Lorenz J, Houser SR, Robbins J, Schwartz A, Molkentin JD. alpha1G-dependent T-type Ca2+ current antagonizes cardiac hypertrophy through a NOS3-dependent mechanism in mice. The Journal of Clinical Investigation. 119: 3787-96. PMID 19920353 DOI: 10.1172/Jci39724  0.457
2009 Andersson KB, Winer LH, Mørk HK, Molkentin JD, Jaisser F. Tamoxifen administration routes and dosage for inducible Cre-mediated gene disruption in mouse hearts. Transgenic Research. 19: 715-25. PMID 19894134 DOI: 10.1007/S11248-009-9342-4  0.415
2009 Millay DP, Goonasekera SA, Sargent MA, Maillet M, Aronow BJ, Molkentin JD. Calcium influx is sufficient to induce muscular dystrophy through a TRPC-dependent mechanism. Proceedings of the National Academy of Sciences of the United States of America. 106: 19023-8. PMID 19864620 DOI: 10.1073/Pnas.0906591106  0.352
2009 Qian J, Ren X, Wang X, Zhang P, Jones WK, Molkentin JD, Fan GC, Kranias EG. Blockade of Hsp20 phosphorylation exacerbates cardiac ischemia/reperfusion injury by suppressed autophagy and increased cell death. Circulation Research. 105: 1223-31. PMID 19850943 DOI: 10.1161/Circresaha.109.200378  0.383
2009 Millay DP, Maillet M, Roche JA, Sargent MA, McNally EM, Bloch RJ, Molkentin JD. Genetic manipulation of dysferlin expression in skeletal muscle: novel insights into muscular dystrophy. The American Journal of Pathology. 175: 1817-23. PMID 19834057 DOI: 10.2353/Ajpath.2009.090107  0.388
2009 Liu Q, Sargent MA, York AJ, Molkentin JD. ASK1 regulates cardiomyocyte death but not hypertrophy in transgenic mice Circulation Research. 105: 1110-1117. PMID 19815822 DOI: 10.1161/Circresaha.109.200741  0.516
2009 Bommireddy R, Bueno OF, Martin J, Ormsby I, Chen H, Gard C, Molkentin JD, Boivin GP, Babcock GF, Doetschman T. Calcineurin deficiency decreases inflammatory lesions in transforming growth factor beta1-deficient mice. Clinical and Experimental Immunology. 158: 317-24. PMID 19747209 DOI: 10.1111/J.1365-2249.2009.04015.X  0.356
2009 Maillet M, Lynch JM, Sanna B, York AJ, Zheng Y, Molkentin JD. Cdc42 is an antihypertrophic molecular switch in the mouse heart. The Journal of Clinical Investigation. 119: 3079-88. PMID 19741299 DOI: 10.1172/Jci37694  0.521
2009 Tkatchenko TV, Moreno-Rodriguez RA, Conway SJ, Molkentin JD, Markwald RR, Tkatchenko AV. Lack of periostin leads to suppression of Notch1 signaling and calcific aortic valve disease. Physiological Genomics. 39: 160-8. PMID 19723774 DOI: 10.1152/Physiolgenomics.00078.2009  0.443
2009 Gelpi RJ, Gao S, Zhai P, Yan L, Hong C, Danridge LM, Ge H, Maejima Y, Donato M, Yokota M, Molkentin JD, Vatner DE, Vatner SF, Sadoshima J. Genetic inhibition of calcineurin induces diastolic dysfunction in mice with chronic pressure overload. American Journal of Physiology. Heart and Circulatory Physiology. 297: H1814-9. PMID 19717730 DOI: 10.1152/Ajpheart.00449.2009  0.402
2009 Sengupta A, Molkentin JD, Yutzey KE. FoxO transcription factors promote autophagy in cardiomyocytes. The Journal of Biological Chemistry. 284: 28319-31. PMID 19696026 DOI: 10.1074/Jbc.M109.024406  0.454
2009 MacDonnell SM, Weisser-Thomas J, Kubo H, Hanscome M, Liu Q, Jaleel N, Berretta R, Chen X, Brown JH, Sabri AK, Molkentin JD, Houser SR. CaMKII negatively regulates calcineurin-NFAT signaling in cardiac myocytes. Circulation Research. 105: 316-25. PMID 19608982 DOI: 10.1161/Circresaha.109.194035  0.422
2009 Liu Q, Chen X, Macdonnell SM, Kranias EG, Lorenz JN, Leitges M, Houser SR, Molkentin JD. Protein kinase C{alpha}, but not PKC{beta} or PKC{gamma}, regulates contractility and heart failure susceptibility: implications for ruboxistaurin as a novel therapeutic approach. Circulation Research. 105: 194-200. PMID 19556521 DOI: 10.1161/Circresaha.109.195313  0.49
2009 Baines CP, Molkentin JD. Adenine nucleotide translocase-1 induces cardiomyocyte death through upregulation of the pro-apoptotic protein Bax. Journal of Molecular and Cellular Cardiology. 46: 969-77. PMID 19452617 DOI: 10.1016/J.Yjmcc.2009.01.016  0.347
2009 Ito K, Akazawa H, Tamagawa M, Furukawa K, Ogawa W, Yasuda N, Kudo Y, Liao CH, Yamamoto R, Sato T, Molkentin JD, Kasuga M, Noda T, Nakaya H, Komuro I. PDK1 coordinates survival pathways and beta-adrenergic response in the heart. Proceedings of the National Academy of Sciences of the United States of America. 106: 8689-94. PMID 19429709 DOI: 10.1073/Pnas.0900064106  0.452
2009 Andersson KB, Birkeland JA, Finsen AV, Louch WE, Sjaastad I, Wang Y, Chen J, Molkentin JD, Chien KR, Sejersted OM, Christensen G. Moderate heart dysfunction in mice with inducible cardiomyocyte-specific excision of the Serca2 gene. Journal of Molecular and Cellular Cardiology. 47: 180-7. PMID 19328205 DOI: 10.1016/J.Yjmcc.2009.03.013  0.427
2009 Wu X, Chang B, Blair NS, Sargent M, York AJ, Robbins J, Shull GE, Molkentin JD. Plasma membrane Ca2+-ATPase isoform 4 antagonizes cardiac hypertrophy in association with calcineurin inhibition in rodents. The Journal of Clinical Investigation. 119: 976-85. PMID 19287093 DOI: 10.1172/Jci36693  0.444
2009 Martin LJ, Gertz B, Pan Y, Price AC, Molkentin JD, Chang Q. The mitochondrial permeability transition pore in motor neurons: involvement in the pathobiology of ALS mice. Experimental Neurology. 218: 333-46. PMID 19272377 DOI: 10.1016/J.Expneurol.2009.02.015  0.328
2009 Sadayappan S, Gulick J, Klevitsky R, Lorenz JN, Sargent M, Molkentin JD, Robbins J. Cardiac myosin binding protein-C phosphorylation in a {beta}-myosin heavy chain background. Circulation. 119: 1253-62. PMID 19237661 DOI: 10.1161/Circulationaha.108.798983  0.407
2009 Carneiro LA, Travassos LH, Soares F, Tattoli I, Magalhaes JG, Bozza MT, Plotkowski MC, Sansonetti PJ, Molkentin JD, Philpott DJ, Girardin SE. Shigella induces mitochondrial dysfunction and cell death in nonmyleoid cells. Cell Host & Microbe. 5: 123-36. PMID 19218084 DOI: 10.1016/J.Chom.2008.12.011  0.322
2009 Liu Q, Busby JC, Molkentin JD. Interaction between TAK1-TAB1-TAB2 and RCAN1-calcineurin defines a signalling nodal control point. Nature Cell Biology. 11: 154-61. PMID 19136967 DOI: 10.1038/Ncb1823  0.399
2009 Yang YJ, Chen W, Edgar A, Li B, Molkentin JD, Berman JN, Lin TJ. Rcan1 negatively regulates Fc epsilonRI-mediated signaling and mast cell function. The Journal of Experimental Medicine. 206: 195-207. PMID 19124655 DOI: 10.1084/Jem.20081140  0.396
2009 Donaldson C, Eder S, Baker C, Aronovitz MJ, Weiss AD, Hall-Porter M, Wang F, Ackerman A, Karas RH, Molkentin JD, Patten RD. Estrogen attenuates left ventricular and cardiomyocyte hypertrophy by an estrogen receptor-dependent pathway that increases calcineurin degradation. Circulation Research. 104: 265-75, 11p followin. PMID 19074476 DOI: 10.1161/Circresaha.108.190397  0.423
2009 Diwan A, Matkovich SJ, Yuan Q, Zhao W, Yatani A, Brown JH, Molkentin JD, Kranias EG, Dorn GW. Endoplasmic reticulum-mitochondria crosstalk in NIX-mediated murine cell death. The Journal of Clinical Investigation. 119: 203-12. PMID 19065046 DOI: 10.1172/Jci36445  0.408
2009 Lorts A, Schwanekamp JA, Elrod JW, Sargent MA, Molkentin JD. Genetic manipulation of periostin expression in the heart does not affect myocyte content, cell cycle activity, or cardiac repair. Circulation Research. 104: e1-7. PMID 19038863 DOI: 10.1161/Circresaha.108.188649  0.705
2009 Hsu S, Nagayama T, Koitabashi N, Zhang M, Zhou L, Bedja D, Gabrielson KL, Molkentin JD, Kass DA, Takimoto E. Phosphodiesterase 5 inhibition blocks pressure overload-induced cardiac hypertrophy independent of the calcineurin pathway. Cardiovascular Research. 81: 301-9. PMID 19029137 DOI: 10.1093/Cvr/Cvn324  0.438
2009 Molkentin JD, Robbins J. With great power comes great responsibility: using mouse genetics to study cardiac hypertrophy and failure. Journal of Molecular and Cellular Cardiology. 46: 130-6. PMID 18845155 DOI: 10.1016/J.Yjmcc.2008.09.002  0.389
2009 Oka T, Takano H, Molkentin JD, Komuro I. P-348 Periostin, Secreted Extracellular Matrix Protein, Plays a Critical Role in Cardiac Hypertrophy and Ventricular Remodeling Cvd Prevention and Control. 4: S150. DOI: 10.1016/S1875-4570(09)60540-4  0.375
2009 Li Y, Zhang X, Tang M, Zhang H, Molkentin J, Houser SR, Chen X. Enhancement of the Cav3.1 Channel Activity by PKA in Ventricular Myocytes of a1G Transgenic Mice Biophysical Journal. 96: 182a. DOI: 10.1016/J.Bpj.2008.12.850  0.389
2008 Conway SJ, Molkentin JD. Periostin as a heterofunctional regulator of cardiac development and disease. Current Genomics. 9: 548-55. PMID 19516962 DOI: 10.2174/138920208786847917  0.444
2008 Blanchard C, Mingler MK, McBride M, Putnam PE, Collins MH, Chang G, Stringer K, Abonia JP, Molkentin JD, Rothenberg ME. Periostin facilitates eosinophil tissue infiltration in allergic lung and esophageal responses. Mucosal Immunology. 1: 289-96. PMID 19079190 DOI: 10.1038/Mi.2008.15  0.396
2008 Krenz M, Gulick J, Osinska HE, Colbert MC, Molkentin JD, Robbins J. Role of ERK1/2 signaling in congenital valve malformations in Noonan syndrome. Proceedings of the National Academy of Sciences of the United States of America. 105: 18930-5. PMID 19017799 DOI: 10.1073/Pnas.0806556105  0.449
2008 Jaleel N, Nakayama H, Chen X, Kubo H, MacDonnell S, Zhang H, Berretta R, Robbins J, Cribbs L, Molkentin JD, Houser SR. Ca2+ influx through T- and L-type Ca2+ channels have different effects on myocyte contractility and induce unique cardiac phenotypes. Circulation Research. 103: 1109-19. PMID 18832749 DOI: 10.1161/Circresaha.108.185611  0.369
2008 Nieves-Cintrón M, Amberg GC, Navedo MF, Molkentin JD, Santana LF. The control of Ca2+ influx and NFATc3 signaling in arterial smooth muscle during hypertension. Proceedings of the National Academy of Sciences of the United States of America. 105: 15623-8. PMID 18832165 DOI: 10.1073/Pnas.0808759105  0.335
2008 Da Costa Martins PA, Bourajjaj M, Gladka M, Kortland M, Van Oort RJ, Pinto YM, Molkentin JD, De Windt LJ. Conditional Dicer gene deletion in the postnatal myocardium provokes spontaneous cardiac remodeling Circulation. 118: 1567-1576. PMID 18809798 DOI: 10.1161/Circulationaha.108.769984  0.306
2008 Maillet M, Purcell NH, Sargent MA, York AJ, Bueno OF, Molkentin JD. DUSP6 (MKP3) null mice show enhanced ERK1/2 phosphorylation at baseline and increased myocyte proliferation in the heart affecting disease susceptibility. The Journal of Biological Chemistry. 283: 31246-55. PMID 18753132 DOI: 10.1074/Jbc.M806085200  0.488
2008 Ramesh S, Qi XJ, Wildey GM, Robinson J, Molkentin J, Letterio J, Howe PH. TGF beta-mediated BIM expression and apoptosis are regulated through SMAD3-dependent expression of the MAPK phosphatase MKP2. Embo Reports. 9: 990-7. PMID 18704116 DOI: 10.1038/Embor.2008.158  0.391
2008 Houser SR, Molkentin JD. Does contractile Ca2+ control calcineurin-NFAT signaling and pathological hypertrophy in cardiac myocytes? Science Signaling. 1: pe31. PMID 18577756 DOI: 10.1126/Scisignal.125Pe31  0.427
2008 Ago T, Liu T, Zhai P, Chen W, Li H, Molkentin JD, Vatner SF, Sadoshima J. A redox-dependent pathway for regulating class II HDACs and cardiac hypertrophy. Cell. 133: 978-93. PMID 18555775 DOI: 10.1016/J.Cell.2008.04.041  0.405
2008 Fuller SJ, Pikkarainen S, Tham el L, Cullingford TE, Molkentin JD, Cornils H, Hergovich A, Hemmings BA, Clerk A, Sugden PH. Nuclear Dbf2-related protein kinases (NDRs) in isolated cardiac myocytes and the myocardium: activation by cellular stresses and by phosphoprotein serine-/threonine-phosphatase inhibitors. Cellular Signalling. 20: 1564-77. PMID 18555663 DOI: 10.1016/J.Cellsig.2008.04.013  0.395
2008 Millay DP, Sargent MA, Osinska H, Baines CP, Barton ER, Vuagniaux G, Sweeney HL, Robbins J, Molkentin JD. Genetic and pharmacologic inhibition of mitochondrial-dependent necrosis attenuates muscular dystrophy. Nature Medicine. 14: 442-7. PMID 18345011 DOI: 10.1038/Nm1736  0.407
2008 Snider P, Hinton RB, Moreno-Rodriguez RA, Wang J, Rogers R, Lindsley A, Li F, Ingram DA, Menick D, Field L, Firulli AB, Molkentin JD, Markwald R, Conway SJ. Periostin is required for maturation and extracellular matrix stabilization of noncardiomyocyte lineages of the heart. Circulation Research. 102: 752-60. PMID 18296617 DOI: 10.1161/Circresaha.107.159517  0.703
2008 Morancho B, Minguillón J, Molkentin JD, López-Rodríguez C, Aramburu J. Analysis of the transcriptional activity of endogenous NFAT5 in primary cells using transgenic NFAT-luciferase reporter mice. Bmc Molecular Biology. 9: 13. PMID 18221508 DOI: 10.1186/1471-2199-9-13  0.355
2008 Pinz I, Ostroy SE, Hoyer K, Osinska H, Robbins J, Molkentin JD, Ingwall JS. Calcineurin-induced energy wasting in a transgenic mouse model of heart failure. American Journal of Physiology. Heart and Circulatory Physiology. 294: H1459-66. PMID 18192216 DOI: 10.1152/Ajpheart.00911.2007  0.398
2008 Sahin B, Hawasli AH, Greene RW, Molkentin JD, Bibb JA. Negative regulation of cyclin-dependent kinase 5 targets by protein kinase C. European Journal of Pharmacology. 581: 270-5. PMID 18190909 DOI: 10.1016/J.Ejphar.2007.11.061  0.324
2008 Manicassamy S, Gupta S, Huang Z, Molkentin JD, Shang W, Sun Z. Requirement of calcineurin a beta for the survival of naive T cells. Journal of Immunology (Baltimore, Md. : 1950). 180: 106-12. PMID 18097009 DOI: 10.4049/Jimmunol.180.1.106  0.302
2008 Gurda GT, Guo L, Lee SH, Molkentin JD, Williams JA. Cholecystokinin activates pancreatic calcineurin-NFAT signaling in vitro and in vivo. Molecular Biology of the Cell. 19: 198-206. PMID 17978097 DOI: 10.1091/Mbc.E07-05-0430  0.36
2007 Jobe SM, Wilson KM, Leo L, Raimondi A, Molkentin JD, Lentz SR, Di Paola J. Critical role for the mitochondrial permeability transition pore and cyclophilin D in platelet activation and thrombosis. Blood. 111: 1257-65. PMID 17989312 DOI: 10.1182/Blood-2007-05-092684  0.313
2007 Heineke J, Auger-Messier M, Xu J, Oka T, Sargent MA, York A, Klevitsky R, Vaikunth S, Duncan SA, Aronow BJ, Robbins J, Crombleholme TM, Cromblehol TM, Molkentin JD. Cardiomyocyte GATA4 functions as a stress-responsive regulator of angiogenesis in the murine heart. The Journal of Clinical Investigation. 117: 3198-210. PMID 17975667 DOI: 10.1172/Jci32573  0.476
2007 Hambleton M, York A, Sargent MA, Kaiser RA, Lorenz JN, Robbins J, Molkentin JD. Inducible and myocyte-specific inhibition of PKCalpha enhances cardiac contractility and protects against infarction-induced heart failure. American Journal of Physiology. Heart and Circulatory Physiology. 293: H3768-71. PMID 17921332 DOI: 10.1152/Ajpheart.00486.2007  0.487
2007 Purcell NH, Wilkins BJ, York A, Saba-El-Leil MK, Meloche S, Robbins J, Molkentin JD. Genetic inhibition of cardiac ERK1/2 promotes stress-induced apoptosis and heart failure but has no effect on hypertrophy in vivo. Proceedings of the National Academy of Sciences of the United States of America. 104: 14074-9. PMID 17709754 DOI: 10.1073/Pnas.0610906104  0.751
2007 Nakayama H, Chen X, Baines CP, Klevitsky R, Zhang X, Zhang H, Jaleel N, Chua BH, Hewett TE, Robbins J, Houser SR, Molkentin JD. Ca2+- and mitochondrial-dependent cardiomyocyte necrosis as a primary mediator of heart failure. The Journal of Clinical Investigation. 117: 2431-44. PMID 17694179 DOI: 10.1172/Jci31060  0.404
2007 Hsieh PC, Segers VF, Davis ME, MacGillivray C, Gannon J, Molkentin JD, Robbins J, Lee RT. Evidence from a genetic fate-mapping study that stem cells refresh adult mammalian cardiomyocytes after injury. Nature Medicine. 13: 970-4. PMID 17660827 DOI: 10.1038/Nm1618  0.37
2007 Nakamura T, Colbert M, Krenz M, Molkentin JD, Hahn HS, Dorn GW, Robbins J. Mediating ERK 1/2 signaling rescues congenital heart defects in a mouse model of Noonan syndrome. The Journal of Clinical Investigation. 117: 2123-32. PMID 17641779 DOI: 10.1172/Jci30756  0.477
2007 Davies KJ, Ermak G, Rothermel BA, Pritchard M, Heitman J, Ahnn J, Henrique-Silva F, Crawford D, Canaider S, Strippoli P, Carinci P, Min KT, Fox DS, Cunningham KW, Bassel-Duby R, ... ... Molkentin JD, et al. Renaming the DSCR1/Adapt78 gene family as RCAN: regulators of calcineurin. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 21: 3023-8. PMID 17595344 DOI: 10.1096/Fj.06-7246Com  0.398
2007 Oka T, Xu J, Kaiser RA, Melendez J, Hambleton M, Sargent MA, Lorts A, Brunskill EW, Dorn GW, Conway SJ, Aronow BJ, Robbins J, Molkentin JD. Genetic manipulation of periostin expression reveals a role in cardiac hypertrophy and ventricular remodeling. Circulation Research. 101: 313-21. PMID 17569887 DOI: 10.1016/J.Cardfail.2007.06.236  0.492
2007 Diwan A, Koesters AG, Odley AM, Pushkaran S, Baines CP, Spike BT, Daria D, Jegga AG, Geiger H, Aronow BJ, Molkentin JD, Macleod KF, Kalfa TA, Dorn GW. Unrestrained erythroblast development in Nix-/- mice reveals a mechanism for apoptotic modulation of erythropoiesis. Proceedings of the National Academy of Sciences of the United States of America. 104: 6794-9. PMID 17420462 DOI: 10.1073/Pnas.0610666104  0.417
2007 Baines CP, Kaiser RA, Sheiko T, Craigen WJ, Molkentin JD. Voltage-dependent anion channels are dispensable for mitochondrial-dependent cell death. Nature Cell Biology. 9: 550-5. PMID 17417626 DOI: 10.1038/Ncb1575  0.33
2007 Parsons SA, Millay DP, Sargent MA, Naya FJ, McNally EM, Sweeney HL, Molkentin JD. Genetic disruption of calcineurin improves skeletal muscle pathology and cardiac disease in a mouse model of limb-girdle muscular dystrophy. The Journal of Biological Chemistry. 282: 10068-78. PMID 17289669 DOI: 10.1074/Jbc.M609368200  0.785
2007 Peng J, Raddatz K, Molkentin JD, Wu Y, Labeit S, Granzier H, Gotthardt M. Cardiac hypertrophy and reduced contractility in hearts deficient in the titin kinase region. Circulation. 115: 743-51. PMID 17261657 DOI: 10.1161/Circulationaha.106.645499  0.448
2007 Norris RA, Damon B, Mironov V, Kasyanov V, Ramamurthi A, Moreno-Rodriguez R, Trusk T, Potts JD, Goodwin RL, Davis J, Hoffman S, Wen X, Sugi Y, Kern CB, Mjaatvedt CH, ... ... Molkentin JD, et al. Periostin regulates collagen fibrillogenesis and the biomechanical properties of connective tissues. Journal of Cellular Biochemistry. 101: 695-711. PMID 17226767 DOI: 10.1002/Jcb.21224  0.329
2007 Nieves-Cintrón M, Amberg GC, Nichols CB, Molkentin JD, Santana LF. Activation of NFATc3 down-regulates the beta1 subunit of large conductance, calcium-activated K+ channels in arterial smooth muscle and contributes to hypertension. The Journal of Biological Chemistry. 282: 3231-40. PMID 17148444 DOI: 10.1074/Jbc.M608822200  0.34
2007 Andersson KB, Finsen AV, Sjaastad I, Wang Y, Chen J, Molkentin JD, Chien KR, Sejersted OM, Christensen G. WITHDRAWN: Heart function in adult cardiac Serca2null mice Journal of Molecular and Cellular Cardiology. DOI: 10.1016/J.Yjmcc.2007.03.841  0.435
2007 Andersson KB, Finsen AV, Sjaastad I, Wang Y, Chen J, Molkentin JD, Chien KR, Sejersted OM, Christensen G. Heart function in adult cardiac Serca2null mice Journal of Molecular and Cellular Cardiology. 42: S106. DOI: 10.1016/J.Yjmcc.2007.03.237  0.434
2007 Bodi I, D'Souza K, Rubio M, Nicolaou S, Fuller G, Conforti L, Molkentin J, Schwartz A. Calcineurin Aβ null partially rescues impaired cardiac function in targeted overexpression of L-LVDCC α1C Journal of Molecular and Cellular Cardiology. 42: S37. DOI: 10.1016/J.Yjmcc.2007.03.104  0.343
2007 Zhang H, Chen X, Gao E, Harris D, Nakayama H, Zhang X, Jaleel N, Eckhart A, Koch W, Molkentin J, Houser S. Excess Ca2+ Influx through the L-Type Ca2+ Channel Exacerbates Ischemia-Induced Cardiac Damage Journal of Cardiac Failure. 13: S87-S88. DOI: 10.1016/J.Cardfail.2007.06.348  0.308
2007 Chen X, Zhang X, Zhang H, Nakayama H, Harris D, Wilson R, Molkentin J, Houser S. Increases in Ca Influx Induces Cardiomyocyte Hypertrophy In Vitro and In Vivo Journal of Cardiac Failure. 13: S71. DOI: 10.1016/J.Cardfail.2007.06.309  0.324
2006 Oka T, Xu J, Molkentin JD. Re-employment of developmental transcription factors in adult heart disease. Seminars in Cell & Developmental Biology. 18: 117-31. PMID 17161634 DOI: 10.1016/J.Semcdb.2006.11.012  0.423
2006 Nilsson LM, Sun ZW, Nilsson J, Nordström I, Chen YW, Molkentin JD, Wide-Swensson D, Hellstrand P, Lydrup ML, Gomez MF. Novel blocker of NFAT activation inhibits IL-6 production in human myometrial arteries and reduces vascular smooth muscle cell proliferation. American Journal of Physiology. Cell Physiology. 292: C1167-78. PMID 17079331 DOI: 10.1152/Ajpcell.00590.2005  0.371
2006 Gong N, Bodi I, Zobel C, Schwartz A, Molkentin JD, Backx PH. Calcineurin increases cardiac transient outward K+ currents via transcriptional up-regulation of Kv4.2 channel subunits. The Journal of Biological Chemistry. 281: 38498-506. PMID 17060317 DOI: 10.1074/Jbc.M607774200  0.372
2006 Heineke J, Molkentin JD. Regulation of cardiac hypertrophy by intracellular signalling pathways. Nature Reviews. Molecular Cell Biology. 7: 589-600. PMID 16936699 DOI: 10.1038/Nrm1983  0.456
2006 Hambleton M, Hahn H, Pleger ST, Kuhn MC, Klevitsky R, Carr AN, Kimball TF, Hewett TE, Dorn GW, Koch WJ, Molkentin JD. Pharmacological- and gene therapy-based inhibition of protein kinase Cα/β enhances cardiac contractility and attenuates heart failure Circulation. 114: 574-582. PMID 16880328 DOI: 10.1161/Circulationaha.105.592550  0.414
2006 Nakayama H, Wilkin BJ, Bodi I, Molkentin JD. Calcineurin-dependent cardiomyopathy is activated by TRPC in the adult mouse heart. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 20: 1660-70. PMID 16873889 DOI: 10.1096/Fj.05-5560Com  0.42
2006 Xin M, Davis CA, Molkentin JD, Lien CL, Duncan SA, Richardson JA, Olson EN. A threshold of GATA4 and GATA6 expression is required for cardiovascular development. Proceedings of the National Academy of Sciences of the United States of America. 103: 11189-94. PMID 16847256 DOI: 10.1073/Pnas.0604604103  0.572
2006 Obasanjo-Blackshire K, Mesquita R, Jabr RI, Molkentin JD, Hart SL, Marber MS, Xia Y, Heads RJ. Calcineurin regulates NFAT-dependent iNOS expression and protection of cardiomyocytes: co-operation with Src tyrosine kinase. Cardiovascular Research. 71: 672-83. PMID 16828070 DOI: 10.1016/J.Cardiores.2006.05.026  0.319
2006 Chen X, Shevtsov SP, Hsich E, Cui L, Haq S, Aronovitz M, Kerkelä R, Molkentin JD, Liao R, Salomon RN, Patten R, Force T. The β-catenin/T-cell factor/lymphocyte enhancer factor signaling pathway is required for normal and stress-induced cardiac hypertrophy Molecular and Cellular Biology. 26: 4462-4473. PMID 16738313 DOI: 10.1128/Mcb.02157-05  0.428
2006 Parsons SA, Millay DP, Sargent MA, McNally EM, Molkentin JD. Age-dependent effect of myostatin blockade on disease severity in a murine model of limb-girdle muscular dystrophy. The American Journal of Pathology. 168: 1975-85. PMID 16723712 DOI: 10.2353/Ajpath.2006.051316  0.768
2006 Noh HL, Okajima K, Molkentin JD, Homma S, Homma S, Goldberg IJ. Acute lipoprotein lipase deletion in adult mice leads to dyslipidemia and cardiac dysfunction. American Journal of Physiology. Endocrinology and Metabolism. 291: E755-60. PMID 16684851 DOI: 10.1152/Ajpendo.00111.2006  0.405
2006 Liu Q, Wilkins BJ, Lee YJ, Ichijo H, Molkentin JD. Direct interaction and reciprocal regulation between ASK1 and calcineurin-NFAT control cardiomyocyte death and growth. Molecular and Cellular Biology. 26: 3785-97. PMID 16648474 DOI: 10.1128/Mcb.26.10.3785-3797.2006  0.706
2006 Sanna B, Brandt EB, Kaiser RA, Pfluger P, Witt SA, Kimball TR, van Rooij E, De Windt LJ, Rothenberg ME, Tschop MH, Benoit SC, Molkentin JD. Modulatory calcineurin-interacting proteins 1 and 2 function as calcineurin facilitators in vivo. Proceedings of the National Academy of Sciences of the United States of America. 103: 7327-32. PMID 16648267 DOI: 10.1073/Pnas.0509340103  0.437
2006 Oka T, Maillet M, Watt AJ, Schwartz RJ, Aronow BJ, Duncan SA, Molkentin JD. Cardiac-specific deletion of Gata4 reveals its requirement for hypertrophy, compensation, and myocyte viability. Circulation Research. 98: 837-45. PMID 16514068 DOI: 10.1161/01.Res.0000215985.18538.C4  0.505
2006 Molkentin JD. Dichotomy of Ca2+ in the heart: contraction versus intracellular signaling. The Journal of Clinical Investigation. 116: 623-6. PMID 16511595 DOI: 10.1172/Jci27824  0.386
2006 Zhao W, Yuan Q, Qian J, Waggoner JR, Pathak A, Chu G, Mitton B, Sun X, Jin J, Braz JC, Hahn HS, Marreez Y, Syed F, Pollesello P, Annila A, ... ... Molkentin JD, et al. The presence of Lys27 instead of Asn27 in human phospholamban promotes sarcoplasmic reticulum Ca2+-ATPase superinhibition and cardiac remodeling. Circulation. 113: 995-1004. PMID 16476846 DOI: 10.1161/Circulationaha.105.583351  0.394
2006 Nilsson J, Nilsson LM, Chen YW, Molkentin JD, Erlinge D, Gomez MF. High glucose activates nuclear factor of activated T cells in native vascular smooth muscle. Arteriosclerosis, Thrombosis, and Vascular Biology. 26: 794-800. PMID 16469950 DOI: 10.1161/01.Atv.0000209513.00765.13  0.325
2006 Xu J, Gong NL, Bodi I, Aronow BJ, Backx PH, Molkentin JD. Myocyte enhancer factors 2A and 2C induce dilated cardiomyopathy in transgenic mice. The Journal of Biological Chemistry. 281: 9152-62. PMID 16469744 DOI: 10.1074/Jbc.M510217200  0.529
2006 Xu J, Kimball TR, Lorenz JN, Brown DA, Bauskin AR, Klevitsky R, Hewett TE, Breit SN, Molkentin JD. GDF15/MIC-1 functions as a protective and antihypertrophic factor released from the myocardium in association with SMAD protein activation. Circulation Research. 98: 342-50. PMID 16397142 DOI: 10.1161/01.Res.0000202804.84885.D0  0.514
2006 Kempf T, Eden M, Strelau J, Naguib M, Willenbockel C, Tongers J, Heineke J, Kotlarz D, Xu J, Molkentin JD, Niessen HW, Drexler H, Wollert KC. The transforming growth factor-beta superfamily member growth-differentiation factor-15 protects the heart from ischemia/reperfusion injury. Circulation Research. 98: 351-60. PMID 16397141 DOI: 10.1161/01.Res.0000202805.73038.48  0.398
2006 Molkentin JD. Locating heart failure. Nature Medicine. 11: 1284-5. PMID 16333267 DOI: 10.1038/Nm1205-1284  0.365
2006 BOURAJJAJ M, ARMAND A, RYBKIN I, BASSELDUBY R, OLSON E, MOLKENTIN J, DEWINDT L. 423 Genome wide expression profiling of NFAT transcriptional activity in a ventricular muscle cell line identifies GATA4 as an NFAT target gene in a feedforward mechanism driving cardiomyocyte hypertrophy European Journal of Heart Failure Supplements. 5: 99-99. DOI: 10.1016/S1567-4215(06)80285-7  0.518
2006 Tang M, Horak K, Zheng H, Molkentin J, Wang X. A120. Activation of the calcineurin-NFAT pathway in desminopathy mouse hearts: The role of proteasomal malfunction Journal of Molecular and Cellular Cardiology. 40: 910. DOI: 10.1016/J.Yjmcc.2006.03.413  0.367
2005 Parlakian A, Charvet C, Escoubet B, Mericskay M, Molkentin JD, Gary-Bobo G, De Windt LJ, Ludosky MA, Paulin D, Daegelen D, Tuil D, Li Z. Temporally controlled onset of dilated cardiomyopathy through disruption of the SRF gene in adult heart. Circulation. 112: 2930-9. PMID 16260633 DOI: 10.1161/Circulationaha.105.533778  0.463
2005 Dai YS, Xu J, Molkentin JD. The DnaJ-related factor Mrj interacts with nuclear factor of activated T cells c3 and mediates transcriptional repression through class II histone deacetylase recruitment. Molecular and Cellular Biology. 25: 9936-48. PMID 16260608 DOI: 10.1128/Mcb.25.22.9936-9948.2005  0.371
2005 Kaiser RA, Lyons JM, Duffy JY, Wagner CJ, McLean KM, O'Neill TP, Pearl JM, Molkentin JD. Inhibition of p38 reduces myocardial infarction injury in the mouse but not pig after ischemia-reperfusion. American Journal of Physiology. Heart and Circulatory Physiology. 289: H2747-51. PMID 16143643 DOI: 10.1152/Ajpheart.01280.2004  0.342
2005 Li J, Patel VV, Kostetskii I, Xiong Y, Chu AF, Jacobson JT, Yu C, Morley GE, Molkentin JD, Radice GL. Cardiac-specific loss of N-cadherin leads to alteration in connexins with conduction slowing and arrhythmogenesis. Circulation Research. 97: 474-81. PMID 16100040 DOI: 10.1161/01.Res.0000181132.11393.18  0.394
2005 Kaiser RA, Liang Q, Bueno O, Huang Y, Lackey T, Klevitsky R, Hewett TE, Molkentin JD. Genetic inhibition or activation of JNK1/2 protects the myocardium from ischemia-reperfusion-induced cell death in vivo. The Journal of Biological Chemistry. 280: 32602-8. PMID 16043490 DOI: 10.1074/Jbc.M500684200  0.486
2005 Oka T, Dai YS, Molkentin JD. Regulation of calcineurin through transcriptional induction of the calcineurin A beta promoter in vitro and in vivo. Molecular and Cellular Biology. 25: 6649-59. PMID 16024800 DOI: 10.1128/Mcb.25.15.6649-6659.2005  0.405
2005 Lynch J, Guo L, Gelebart P, Chilibeck K, Xu J, Molkentin JD, Agellon LB, Michalak M. Calreticulin signals upstream of calcineurin and MEF2C in a critical Ca(2+)-dependent signaling cascade. The Journal of Cell Biology. 170: 37-47. PMID 15998798 DOI: 10.1083/Jcb.200412156  0.48
2005 Baines CP, Kaiser RA, Purcell NH, Blair NS, Osinska H, Hambleton MA, Brunskill EW, Sayen MR, Gottlieb RA, Dorn GW, Robbins J, Molkentin JD. Loss of cyclophilin D reveals a critical role for mitochondrial permeability transition in cell death. Nature. 434: 658-62. PMID 15800627 DOI: 10.1038/Nature03434  0.373
2005 Heineke J, Ruetten H, Willenbockel C, Gross SC, Naguib M, Schaefer A, Kempf T, Hilfiker-Kleiner D, Caroni P, Kraft T, Kaiser RA, Molkentin JD, Drexler H, Wollert KC. Attenuation of cardiac remodeling after myocardial infarction by muscle LIM protein-calcineurin signaling at the sarcomeric Z-disc. Proceedings of the National Academy of Sciences of the United States of America. 102: 1655-60. PMID 15665106 DOI: 10.1073/Pnas.0405488102  0.485
2005 Kostetskii I, Li J, Xiong Y, Zhou R, Ferrari VA, Patel VV, Molkentin JD, Radice GL. Induced deletion of the N-cadherin gene in the heart leads to dissolution of the intercalated disc structure. Circulation Research. 96: 346-54. PMID 15662031 DOI: 10.1161/01.Res.0000156274.72390.2C  0.403
2005 Sanna B, Bueno OF, Dai YS, Wilkins BJ, Molkentin JD. Direct and indirect interactions between calcineurin-NFAT and MEK1-extracellular signal-regulated kinase 1/2 signaling pathways regulate cardiac gene expression and cellular growth. Molecular and Cellular Biology. 25: 865-78. PMID 15657416 DOI: 10.1128/Mcb.25.3.865-878.2005  0.735
2005 Baines CP, Molkentin JD. STRESS signaling pathways that modulate cardiac myocyte apoptosis. Journal of Molecular and Cellular Cardiology. 38: 47-62. PMID 15623421 DOI: 10.1016/J.Yjmcc.2004.11.004  0.433
2005 Zhang L, Deng M, Parthasarathy R, Wang L, Mongan M, Molkentin JD, Zheng Y, Xia Y. MEKK1 transduces activin signals in keratinocytes to induce actin stress fiber formation and migration. Molecular and Cellular Biology. 25: 60-5. PMID 15601830 DOI: 10.1128/Mcb.25.1.60-65.2005  0.39
2005 Bell O, Gaberman E, Kilav R, Levi R, Cox KB, Molkentin JD, Silver J, Naveh-Many T. The protein phosphatase calcineurin determines basal parathyroid hormone gene expression. Molecular Endocrinology (Baltimore, Md.). 19: 516-26. PMID 15514034 DOI: 10.1210/Me.2004-0108  0.318
2004 Matsuura K, Wada H, Nagai T, Iijima Y, Minamino T, Sano M, Akazawa H, Molkentin JD, Kasanuki H, Komuro I. Cardiomyocytes fuse with surrounding noncardiomyocytes and reenter the cell cycle. The Journal of Cell Biology. 167: 351-63. PMID 15492039 DOI: 10.1083/Jcb.200312111  0.359
2004 Wilkins BJ, Molkentin JD. Calcium-calcineurin signaling in the regulation of cardiac hypertrophy. Biochemical and Biophysical Research Communications. 322: 1178-91. PMID 15336966 DOI: 10.1016/J.Bbrc.2004.07.121  0.735
2004 Molkentin JD. Calcineurin-NFAT signaling regulates the cardiac hypertrophic response in coordination with the MAPKs. Cardiovascular Research. 63: 467-75. PMID 15276472 DOI: 10.1016/J.Cardiores.2004.01.021  0.479
2004 Lips DJ, Bueno OF, Wilkins BJ, Purcell NH, Kaiser RA, Lorenz JN, Voisin L, Saba-El-Leil MK, Meloche S, Pouysségur J, Pagès G, De Windt LJ, Doevendans PA, Molkentin JD. MEK1-ERK2 signaling pathway protects myocardium from ischemic injury in vivo. Circulation. 109: 1938-41. PMID 15096454 DOI: 10.1161/01.Cir.0000127126.73759.23  0.722
2004 Parsons SA, Millay DP, Wilkins BJ, Bueno OF, Tsika GL, Neilson JR, Liberatore CM, Yutzey KE, Crabtree GR, Tsika RW, Molkentin JD. Genetic loss of calcineurin blocks mechanical overload-induced skeletal muscle fiber type switching but not hypertrophy. The Journal of Biological Chemistry. 279: 26192-200. PMID 15082723 DOI: 10.1074/Jbc.M313800200  0.81
2004 Aliahmad P, O'Flaherty E, Han P, Goularte OD, Wilkinson B, Satake M, Molkentin JD, Kaye J. TOX provides a link between calcineurin activation and CD8 lineage commitment. The Journal of Experimental Medicine. 199: 1089-99. PMID 15078895 DOI: 10.1084/Jem.20040051  0.332
2004 Michael A, Haq S, Chen X, Hsich E, Cui L, Walters B, Shao Z, Bhattacharya K, Kilter H, Huggins G, Andreucci M, Periasamy M, Solomon RN, Liao R, Patten R, ... Molkentin JD, et al. Glycogen synthase kinase-3beta regulates growth, calcium homeostasis, and diastolic function in the heart. The Journal of Biological Chemistry. 279: 21383-93. PMID 15020584 DOI: 10.1074/Jbc.M401413200  0.438
2004 Braz JC, Gregory K, Pathak A, Zhao W, Sahin B, Klevitsky R, Kimball TF, Lorenz JN, Nairn AC, Liggett SB, Bodi I, Wang S, Schwartz A, Lakatta EG, DePaoli-Roach AA, ... ... Molkentin JD, et al. PKC-alpha regulates cardiac contractility and propensity toward heart failure. Nature Medicine. 10: 248-54. PMID 14966518 DOI: 10.1038/Nm1000  0.448
2004 Kaiser RA, Bueno OF, Lips DJ, Doevendans PA, Jones F, Kimball TF, Molkentin JD. Targeted inhibition of p38 mitogen-activated protein kinase antagonizes cardiac injury and cell death following ischemia-reperfusion in vivo. The Journal of Biological Chemistry. 279: 15524-30. PMID 14749328 DOI: 10.1074/Jbc.M313717200  0.468
2004 Lange AW, Molkentin JD, Yutzey KE. DSCR1 gene expression is dependent on NFATc1 during cardiac valve formation and colocalizes with anomalous organ development in trisomy 16 mice. Developmental Biology. 266: 346-60. PMID 14738882 DOI: 10.1016/J.Ydbio.2003.10.036  0.434
2004 Dorn GW, Molkentin JD. Manipulating cardiac contractility in heart failure: data from mice and men. Circulation. 109: 150-8. PMID 14734503 DOI: 10.1161/01.Cir.0000111581.15521.F5  0.403
2004 Purcell NH, Darwis D, Bueno OF, Müller JM, Schüle R, Molkentin JD. Extracellular signal-regulated kinase 2 interacts with and is negatively regulated by the LIM-only protein FHL2 in cardiomyocytes. Molecular and Cellular Biology. 24: 1081-95. PMID 14729955 DOI: 10.1128/Mcb.24.3.1081-1095.2004  0.437
2004 Wilkins BJ, Dai YS, Bueno OF, Parsons SA, Xu J, Plank DM, Jones F, Kimball TR, Molkentin JD. Calcineurin/NFAT coupling participates in pathological, but not physiological, cardiac hypertrophy. Circulation Research. 94: 110-8. PMID 14656927 DOI: 10.1161/01.Res.0000109415.17511.18  0.832
2004 Liang Q, Molkentin JD. Redefining the roles of p38 and JNK signaling in cardiac hypertrophy: dichotomy between cultured myocytes and animal models. Journal of Molecular and Cellular Cardiology. 35: 1385-94. PMID 14654364 DOI: 10.1016/J.Yjmcc.2003.10.001  0.455
2004 Bueno OF, Lips DJ, Kaiser RA, Wilkins BJ, Dai YS, Glascock BJ, Klevitsky R, Hewett TE, Kimball TR, Aronow BJ, Doevendans PA, Molkentin JD. Calcineurin Abeta gene targeting predisposes the myocardium to acute ischemia-induced apoptosis and dysfunction. Circulation Research. 94: 91-9. PMID 14615291 DOI: 10.1161/01.Res.0000107197.99679.77  0.735
2003 Prabhakar R, Petrashevskaya N, Schwartz A, Aronow B, Boivin GP, Molkentin JD, Wieczorek DF. A mouse model of familial hypertrophic cardiomyopathy caused by a alpha-tropomyosin mutation. Molecular and Cellular Biochemistry. 251: 33-42. PMID 14575301 DOI: 10.1023/A:1025409227350  0.306
2003 Liang Q, Bueno OF, Wilkins BJ, Kuan CY, Xia Y, Molkentin JD. c-Jun N-terminal kinases (JNK) antagonize cardiac growth through cross-talk with calcineurin-NFAT signaling. The Embo Journal. 22: 5079-89. PMID 14517246 DOI: 10.1093/Emboj/Cdg474  0.747
2003 Purcell NH, Molkentin JD. Is nuclear factor kappaB an attractive therapeutic target for treating cardiac hypertrophy? Circulation. 108: 638-40. PMID 12912791 DOI: 10.1161/01.Cir.0000085362.40608.Dd  0.455
2003 Haq S, Kilter H, Michael A, Tao J, O'Leary E, Sun XM, Walters B, Bhattacharya K, Chen X, Cui L, Andreucci M, Rosenzweig A, Guerrero JL, Patten R, Liao R, ... Molkentin J, et al. Deletion of cytosolic phospholipase A2 promotes striated muscle growth Nature Medicine. 9: 944-951. PMID 12808451 DOI: 10.1038/Nm891  0.419
2003 Schubert W, Yang XY, Yang TT, Factor SM, Lisanti MP, Molkentin JD, Rincon M, Chow CW. Requirement of transcription factor NFAT in developing atrial myocardium. The Journal of Cell Biology. 161: 861-74. PMID 12796475 DOI: 10.1083/Jcb.200301058  0.448
2003 Parsons SA, Wilkins BJ, Bueno OF, Molkentin JD. Altered skeletal muscle phenotypes in calcineurin Aalpha and Abeta gene-targeted mice. Molecular and Cellular Biology. 23: 4331-43. PMID 12773574 DOI: 10.1128/Mcb.23.12.4331-4343.2003  0.801
2003 Braz JC, Bueno OF, Liang Q, Wilkins BJ, Dai YS, Parsons S, Braunwart J, Glascock BJ, Klevitsky R, Kimball TF, Hewett TE, Molkentin JD. Targeted inhibition of p38 MAPK promotes hypertrophic cardiomyopathy through upregulation of calcineurin-NFAT signaling. The Journal of Clinical Investigation. 111: 1475-86. PMID 12750397 DOI: 10.1172/Jci17295  0.833
2003 Bushdid PB, Osinska H, Waclaw RR, Molkentin JD, Yutzey KE. NFATc3 and NFATc4 are required for cardiac development and mitochondrial function. Circulation Research. 92: 1305-13. PMID 12750314 DOI: 10.1161/01.Res.0000077045.84609.9F  0.495
2003 Molkentin JD. A friend within the heart: natriuretic peptide receptor signaling. The Journal of Clinical Investigation. 111: 1275-7. PMID 12727915 DOI: 10.1172/Jci18389  0.459
2003 Suzuki YJ, Day RM, Tan CC, Sandven TH, Liang Q, Molkentin JD, Fanburg BL. Activation of GATA-4 by serotonin in pulmonary artery smooth muscle cells. The Journal of Biological Chemistry. 278: 17525-31. PMID 12615926 DOI: 10.1074/Jbc.M210465200  0.319
2003 Petrich BG, Molkentin JD, Wang Y. Temporal activation of c-Jun N-terminal kinase in adult transgenic heart via cre-loxP-mediated DNA recombination. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 17: 749-51. PMID 12594183 DOI: 10.1096/Fj.02-0438Fje  0.449
2003 Rybin VO, Sabri A, Short J, Braz JC, Molkentin JD, Steinberg SF. Cross-regulation of novel protein kinase C (PKC) isoform function in cardiomyocytes. Role of PKC epsilon in activation loop phosphorylations and PKC delta in hydrophobic motif phosphorylations. The Journal of Biological Chemistry. 278: 14555-64. PMID 12566450 DOI: 10.1074/Jbc.M212644200  0.335
2003 Dong D, Duan Y, Guo J, Roach DE, Swirp SL, Wang L, Lees-Miller JP, Sheldon RS, Molkentin JD, Duff HJ. Overexpression of calcineurin in mouse causes sudden cardiac death associated with decreased density of K+ channels. Cardiovascular Research. 57: 320-32. PMID 12566105 DOI: 10.1016/S0008-6363(02)00661-2  0.406
2003 Gajewski K, Wang J, Molkentin JD, Chen EH, Olson EN, Schulz RA. Requirement of the calcineurin subunit gene canB2 for indirect flight muscle formation in Drosophila. Proceedings of the National Academy of Sciences of the United States of America. 100: 1040-5. PMID 12538857 DOI: 10.1073/Pnas.0337662100  0.703
2003 Sayen MR, Gustafsson AB, Sussman MA, Molkentin JD, Gottlieb RA. Calcineurin transgenic mice have mitochondrial dysfunction and elevated superoxide production. American Journal of Physiology. Cell Physiology. 284: C562-70. PMID 12397029 DOI: 10.1152/Ajpcell.00336.2002  0.339
2003 Michael A, Haq S, Kilter H, Chen X, Liao R, Cui L, Patten R, Molkentin J, Battacharya K, Force T. Cardiac-specific expression of GSK-3 impairs cardiac growth and calcium handling, leading to systolic and diastolic dysfunction, heart failure, and premature death Journal of Cardiac Failure. 9: S39. DOI: 10.1016/S1071-9164(03)00489-5  0.435
2003 Prabhakar R, Petrashevskaya N, Schwartz A, Aronow B, Boivin GP, Molkentin JD, Wieczorek DF. A mouse model of familial hypertrophic cardiomyopathy caused by a α-tropomyosin mutation Molecular and Cellular Biochemistry. 251: 33-42. DOI: 10.1007/978-1-4419-9238-3_5  0.423
2002 Bueno OF, Molkentin JD. Involvement of extracellular signal-regulated kinases 1/2 in cardiac hypertrophy and cell death. Circulation Research. 91: 776-81. PMID 12411391 DOI: 10.1161/01.Res.0000038488.38975.1A  0.481
2002 Semeniuk LM, Severson DL, Kryski AJ, Swirp SL, Molkentin JD, Duff HJ. Time-dependent systolic and diastolic function in mice overexpressing calcineurin. American Journal of Physiology. Heart and Circulatory Physiology. 284: H425-30. PMID 12388248 DOI: 10.1152/Ajpheart.00546.2002  0.404
2002 Wilkins BJ, De Windt LJ, Bueno OF, Braz JC, Glascock BJ, Kimball TF, Molkentin JD. Targeted disruption of NFATc3, but not NFATc4, reveals an intrinsic defect in calcineurin-mediated cardiac hypertrophic growth. Molecular and Cellular Biology. 22: 7603-13. PMID 12370307 DOI: 10.1128/Mcb.22.21.7603-7613.2002  0.757
2002 Tomita M, Reinhold MI, Molkentin JD, Naski MC. Calcineurin and NFAT4 induce chondrogenesis. The Journal of Biological Chemistry. 277: 42214-8. PMID 12239209 DOI: 10.1074/Jbc.C200504200  0.385
2002 van Rooij E, Doevendans PA, de Theije CC, Babiker FA, Molkentin JD, de Windt LJ. Requirement of nuclear factor of activated T-cells in calcineurin-mediated cardiomyocyte hypertrophy. The Journal of Biological Chemistry. 277: 48617-26. PMID 12226086 DOI: 10.1074/Jbc.M206532200  0.479
2002 Fiedler B, Lohmann SM, Smolenski A, Linnemuller S, Pieske B, Schroder F, Molkentin JD, Drexler H, Wollert KC. Inhibition of calcineurin-NFAT hypertrophy signaling by cGMP-dependent protein kinase type I in cardiac myocytes. Proceedings of the National Academy of Sciences of the United States of America. 99: 11363-8. PMID 12177418 DOI: 10.1073/Pnas.162100799  0.449
2002 Jacob A, Molkentin JD, Smolenski A, Lohmann SM, Begum N. Insulin inhibits PDGF-directed VSMC migration via NO/ cGMP increase of MKP-1 and its inactivation of MAPKs. American Journal of Physiology. Cell Physiology. 283: C704-13. PMID 12176727 DOI: 10.1152/Ajpcell.00110.2002  0.311
2002 Bueno OF, Brandt EB, Rothenberg ME, Molkentin JD. Defective T cell development and function in calcineurin A beta -deficient mice. Proceedings of the National Academy of Sciences of the United States of America. 99: 9398-403. PMID 12091710 DOI: 10.1073/Pnas.152665399  0.358
2002 Petrashevskaya NN, Bodi I, Rubio M, Molkentin JD, Schwartz A. Cardiac function and electrical remodeling of the calcineurin-overexpressed transgenic mouse. Cardiovascular Research. 54: 117-32. PMID 12062368 DOI: 10.1016/S0008-6363(02)00241-9  0.415
2002 Chu G, Carr AN, Young KB, Lester JW, Yatani A, Sanbe A, Colbert MC, Schwartz SM, Frank KF, Lampe PD, Robbins J, Molkentin JD, Kranias EG. Enhanced myocyte contractility and Ca2+ handling in a calcineurin transgenic model of heart failure. Cardiovascular Research. 54: 105-16. PMID 12062367 DOI: 10.1016/S0008-6363(02)00230-4  0.447
2002 Liang Q, Molkentin JD. Divergent signaling pathways converge on GATA4 to regulate cardiac hypertrophic gene expression Journal of Molecular and Cellular Cardiology. 34: 611-616. PMID 12054848 DOI: 10.1006/Jmcc.2002.2011  0.42
2002 Wilkins BJ, Molkentin JD. Calcineurin and cardiac hypertrophy: where have we been? Where are we going? The Journal of Physiology. 541: 1-8. PMID 12015416 DOI: 10.1113/Jphysiol.2002.017129  0.74
2002 Dai YS, Cserjesi P, Markham BE, Molkentin JD. The transcription factors GATA4 and dHAND physically interact to synergistically activate cardiac gene expression through a p300-dependent mechanism. The Journal of Biological Chemistry. 277: 24390-8. PMID 11994297 DOI: 10.1074/Jbc.M202490200  0.403
2002 Sah R, Oudit GY, Nguyen TT, Lim HW, Wickenden AD, Wilson GJ, Molkentin JD, Backx PH. Inhibition of calcineurin and sarcolemmal Ca2+ influx protects cardiac morphology and ventricular function in K(v)4.2N transgenic mice. Circulation. 105: 1850-6. PMID 11956130 DOI: 10.1161/01.Cir.0000014211.47830.4D  0.413
2002 Bueno OF, van Rooij E, Molkentin JD, Doevendans PA, De Windt LJ. Calcineurin and hypertrophic heart disease: novel insights and remaining questions. Cardiovascular Research. 53: 806-21. PMID 11922891 DOI: 10.1016/S0008-6363(01)00493-X  0.45
2002 Bueno OF, Wilkins BJ, Tymitz KM, Glascock BJ, Kimball TF, Lorenz JN, Molkentin JD. Impaired cardiac hypertrophic response in Calcineurin Abeta -deficient mice. Proceedings of the National Academy of Sciences of the United States of America. 99: 4586-91. PMID 11904392 DOI: 10.1073/Pnas.072647999  0.752
2002 Braz JC, Bueno OF, De Windt LJ, Molkentin JD. PKC alpha regulates the hypertrophic growth of cardiomyocytes through extracellular signal-regulated kinase1/2 (ERK1/2). The Journal of Cell Biology. 156: 905-19. PMID 11864993 DOI: 10.1083/Jcb.200108062  0.359
2002 Dai Y, Markham BE, Molkentin JD. 13 GATA4 and dHAND physically interact to synergistically activate cardiac gene expression via A p300-dependent mechanism Journal of Molecular and Cellular Cardiology. 34: A42. DOI: 10.1016/S0022-2828(02)90221-X  0.373
2002 Braz JC, Bueno OF, Wilkins BJ, Braunwart J, Molkentin JD. 05 Inhibition of p38 mitogen-activated protein kinase (MAPK) leads to hypertrophic cardiomyopathy Journal of Molecular and Cellular Cardiology. 34: A12. DOI: 10.1016/S0022-2828(02)90111-2  0.658
2001 Charron F, Tsimiklis G, Arcand M, Robitaille L, Liang Q, Molkentin JD, Meloche S, Nemer M. Tissue-specific GATA factors are transcriptional effectors of the small GTPase RhoA. Genes & Development. 15: 2702-19. PMID 11641276 DOI: 10.1101/Gad.915701  0.494
2001 Liang Q, Wiese RJ, Bueno OF, Dai YS, Markham BE, Molkentin JD. The transcription factor GATA4 is activated by extracellular signal-regulated kinase 1- and 2-mediated phosphorylation of serine 105 in cardiomyocytes. Molecular and Cellular Biology. 21: 7460-9. PMID 11585926 DOI: 10.1128/Mcb.21.21.7460-7469.2001  0.403
2001 Sohal DS, Nghiem M, Crackower MA, Witt SA, Kimball TR, Tymitz KM, Penninger JM, Molkentin JD. Temporally regulated and tissue-specific gene manipulations in the adult and embryonic heart using a tamoxifen-inducible Cre protein. Circulation Research. 89: 20-5. PMID 11440973 DOI: 10.1161/Hh1301.092687  0.471
2001 Molkentin JD. Calcineurin, mitochondrial membrane potential, and cardiomyocyte apoptosis. Circulation Research. 88: 1220-2. PMID 11420294 DOI: 10.1161/Hh1201.093159  0.358
2001 Li J, Molkentin JD, Colbert MC. Retinoic acid inhibits cardiac neural crest migration by blocking c-Jun N-terminal kinase activation. Developmental Biology. 232: 351-61. PMID 11401397 DOI: 10.1006/Dbio.2001.0203  0.353
2001 Aronow BJ, Toyokawa T, Canning A, Haghighi K, Delling U, Kranias E, Molkentin JD, Dorn GW. Divergent transcriptional responses to independent genetic causes of cardiac hypertrophy Physiological Genomics. 6: 19-28. PMID 11395543 DOI: 10.1152/Physiolgenomics.2001.6.1.19  0.394
2001 Liang Q, De Windt LJ, Witt SA, Kimball TR, Markham BE, Molkentin JD. The transcription factors GATA4 and GATA6 regulate cardiomyocyte hypertrophy in vitro and in vivo. The Journal of Biological Chemistry. 276: 30245-53. PMID 11356841 DOI: 10.1074/Jbc.M102174200  0.508
2001 Crispino JD, Lodish MB, Thurberg BL, Litovsky SH, Collins T, Molkentin JD, Orkin SH. Proper coronary vascular development and heart morphogenesis depend on interaction of GATA-4 with FOG cofactors Genes and Development. 15: 839-844. PMID 11297508 DOI: 10.1101/Gad.875201  0.454
2001 Lim HW, New L, Han J, Molkentin JD. Calcineurin enhances MAPK phosphatase-1 expression and p38 MAPK inactivation in cardiac myocytes. The Journal of Biological Chemistry. 276: 15913-9. PMID 11279073 DOI: 10.1074/Jbc.M100452200  0.467
2001 De Windt LJ, Lim HW, Bueno OF, Liang Q, Delling U, Braz JC, Glascock BJ, Kimball TF, del Monte F, Hajjar RJ, Molkentin JD. Targeted inhibition of calcineurin attenuates cardiac hypertrophy in vivo. Proceedings of the National Academy of Sciences of the United States of America. 98: 3322-7. PMID 11248077 DOI: 10.1073/Pnas.031371998  0.5
2001 Molkentin JD, Dorn GW. Cytoplasmic signaling pathways that regulate cardiac hypertrophy. Annual Review of Physiology. 63: 391-426. PMID 11181961 DOI: 10.1146/Annurev.Physiol.63.1.391  0.435
2001 Yatani A, Honda R, Tymitz KM, Lalli MJ, Molkentin JD. Enhanced Ca2+ channel currents in cardiac hypertrophy induced by activation of calcineurin-dependent pathway. Journal of Molecular and Cellular Cardiology. 33: 249-59. PMID 11162130 DOI: 10.1006/Jmcc.2000.1296  0.375
2001 Haq S, Choukroun G, Lim H, Tymitz KM, del Monte F, Gwathmey J, Grazette L, Michael A, Hajjar R, Force T, Molkentin JD. Differential activation of signal transduction pathways in human hearts with hypertrophy versus advanced heart failure. Circulation. 103: 670-7. PMID 11156878 DOI: 10.1161/01.Cir.103.5.670  0.406
2001 Han J, Molkentin JD. Regulation of MEF2 by p38 MAPK and its implication in cardiomyocyte biology. Trends in Cardiovascular Medicine. 10: 19-22. PMID 11150724 DOI: 10.1016/S1050-1738(00)00039-6  0.443
2001 Bueno OF, De Windt LJ, Lim HW, Tymitz KM, Witt SA, Kimball TR, Molkentin JD. The dual-specificity phosphatase MKP-1 limits the cardiac hypertrophic response in vitro and in vivo. Circulation Research. 88: 88-96. PMID 11139479 DOI: 10.1161/01.Res.88.1.88  0.487
2001 Molkentin JD. The zinc finger-containing transcription factors GATA-4, -5, and -6. Ubiquitously expressed regulators of tissue-specific gene expression. The Journal of Biological Chemistry. 275: 38949-52. PMID 11042222 DOI: 10.1074/Jbc.R000029200  0.317
2001 Wilkins BJ, DeWindt LJ, Bueno OF, Braz JC, Molkentin JD. Loss of NF-ATc3, not NF-ATc4, attenuates cardiac hypertrophy induced by calcineurin activation in vivo Journal of Molecular and Cellular Cardiology. 33: A130. DOI: 10.1016/S0022-2828(01)90519-X  0.687
2001 Bueno OF, Wilkins BJ, Klevitsky R, Hewitt TE, Molkentin JD. Impaired hypertrophic response in calcineurin Aβ-deficient mice Journal of Molecular and Cellular Cardiology. 33: A17. DOI: 10.1016/S0022-2828(01)90066-5  0.66
2001 Braz JC, De Windt LJ, Molkentin JD. Characterization of protein kinase C (PKC) function in cardiomyocyte hypertrophy Journal of Molecular and Cellular Cardiology. 33: A16. DOI: 10.1016/S0022-2828(01)90062-8  0.303
2000 Bueno OF, De Windt LJ, Tymitz KM, Witt SA, Kimball TR, Klevitsky R, Hewett TE, Jones SP, Lefer DJ, Peng CF, Kitsis RN, Molkentin JD. The MEK1-ERK1/2 signaling pathway promotes compensated cardiac hypertrophy in transgenic mice. The Embo Journal. 19: 6341-50. PMID 11101507 DOI: 10.1093/Emboj/19.23.6341  0.651
2000 Molkentin JD. Calcineurin and beyond: cardiac hypertrophic signaling. Circulation Research. 87: 731-8. PMID 11055975 DOI: 10.1161/01.Res.87.9.731  0.471
2000 Delling U, Sussman MA, Molkentin JD. Re-evaluating sarcoplasmic reticulum function in heart failure. Nature Medicine. 6: 942-3. PMID 10973288 DOI: 10.1038/79592  0.408
2000 Delling U, Tureckova J, Lim HW, De Windt LJ, Rotwein P, Molkentin JD. A calcineurin-NFATc3-dependent pathway regulates skeletal muscle differentiation and slow myosin heavy-chain expression. Molecular and Cellular Biology. 20: 6600-11. PMID 10938134 DOI: 10.1128/Mcb.20.17.6600-6611.2000  0.417
2000 Molkentin JD, Tymitz KM, Richardson JA, Olson EN. Abnormalities of the genitourinary tract in female mice lacking GATA5. Molecular and Cellular Biology. 20: 5256-60. PMID 10866681 DOI: 10.1128/Mcb.20.14.5256-5260.2000  0.526
2000 Lim HW, De Windt LJ, Steinberg L, Taigen T, Witt SA, Kimball TR, Molkentin JD. Calcineurin expression, activation, and function in cardiac pressure-overload hypertrophy. Circulation. 101: 2431-7. PMID 10821822 DOI: 10.1161/01.Cir.101.20.2431  0.45
2000 De Windt LJ, Lim HW, Haq S, Force T, Molkentin JD. Calcineurin promotes protein kinase C and c-Jun NH2-terminal kinase activation in the heart. Cross-talk between cardiac hypertrophic signaling pathways. The Journal of Biological Chemistry. 275: 13571-9. PMID 10788473 DOI: 10.1074/Jbc.275.18.13571  0.442
2000 Lim HW, De Windt LJ, Mante J, Kimball TR, Witt SA, Sussman MA, Molkentin JD. Reversal of cardiac hypertrophy in transgenic disease models by calcineurin inhibition. Journal of Molecular and Cellular Cardiology. 32: 697-709. PMID 10756124 DOI: 10.1006/Jmcc.2000.1113  0.481
2000 Sussman MA, Welch S, Walker A, Klevitsky R, Hewett TE, Witt SA, Kimball TR, Price R, Lim HW, Molkentin JD. Hypertrophic defect unmasked by calcineurin expression in asymptomatic tropomodulin overexpressing transgenic mice. Cardiovascular Research. 46: 90-101. PMID 10727657 DOI: 10.1016/S0008-6363(99)00422-8  0.38
2000 De Windt LJ, Lim HW, Taigen T, Wencker D, Condorelli G, Dorn GW, Kitsis RN, Molkentin JD. Calcineurin-mediated hypertrophy protects cardiomyocytes from apoptosis in vitro and in vivo. An apoptosis-independent model of dilated heart failure Circulation Research. 86: 255-263. PMID 10679475 DOI: 10.1161/01.Res.86.3.255  0.485
2000 Taigen T, De Windt LJ, Lim HW, Molkentin JD. Targeted inhibition of calcineurin prevents agonist-induced cardiomyocyte hypertrophy. Proceedings of the National Academy of Sciences of the United States of America. 97: 1196-201. PMID 10655507 DOI: 10.1073/Pnas.97.3.1196  0.438
2000 Molkentin JD, Antos C, Mercer B, Taigen T, Miano JM, Olson EN. Direct activation of a GATA6 cardiac enhancer by Nkx2.5: evidence for a reinforcing regulatory network of Nkx2.5 and GATA transcription factors in the developing heart. Developmental Biology. 217: 301-9. PMID 10625555 DOI: 10.1006/Dbio.1999.9544  0.594
1999 Sussman MA, Welch S, Gude N, Khoury PR, Daniels SR, Kirkpatrick D, Walsh RA, Price RL, Lim HW, Molkentin JD. Pathogenesis of dilated cardiomyopathy: molecular, structural, and population analyses in tropomodulin-overexpressing transgenic mice. The American Journal of Pathology. 155: 2101-13. PMID 10595939 DOI: 10.1016/S0002-9440(10)65528-9  0.405
1999 Olson EN, Molkentin JD. Prevention of cardiac hypertrophy by calcineurin inhibition: hope or hype? Circulation Research. 84: 623-32. PMID 10189350 DOI: 10.1161/01.Res.84.6.623  0.586
1999 Lim HW, Molkentin JD. Calcineurin and human heart failure. Nature Medicine. 5: 246-7. PMID 10086361 DOI: 10.1038/6430  0.327
1999 Wilson-Rawls J, Molkentin JD, Black BL, Olson EN. Activated notch inhibits myogenic activity of the MADS-Box transcription factor myocyte enhancer factor 2C. Molecular and Cellular Biology. 19: 2853-62. PMID 10082551 DOI: 10.1128/Mcb.19.4.2853  0.682
1998 Sussman MA, Lim HW, Gude N, Taigen T, Olson EN, Robbins J, Colbert MC, Gualberto A, Wieczorek DF, Molkentin JD. Prevention of cardiac hypertrophy in mice by calcineurin inhibition. Science (New York, N.Y.). 281: 1690-3. PMID 9733519 DOI: 10.1126/Science.281.5383.1690  0.57
1998 Molkentin JD, Lu JR, Antos CL, Markham B, Richardson J, Robbins J, Grant SR, Olson EN. A calcineurin-dependent transcriptional pathway for cardiac hypertrophy. Cell. 93: 215-28. PMID 9568714 DOI: 10.1016/S0092-8674(00)81573-1  0.755
1998 Katoh Y, Molkentin JD, Dave V, Olson EN, Periasamy M. MEF2B is a component of a smooth muscle-specific complex that binds an A/T-rich element important for smooth muscle myosin heavy chain gene expression. The Journal of Biological Chemistry. 273: 1511-8. PMID 9430690 DOI: 10.1074/Jbc.273.3.1511  0.49
1998 Black BL, Molkentin JD, Olson EN. Multiple roles for the MyoD basic region in transmission of transcriptional activation signals and interaction with MEF2. Molecular and Cellular Biology. 18: 69-77. PMID 9418854 DOI: 10.1128/Mcb.18.1.69  0.668
1997 Herzig TC, Jobe SM, Aoki H, Molkentin JD, Cowley AW, Izumo S, Markham BE. Angiotensin II type1a receptor gene expression in the heart: AP-1 and GATA-4 participate in the response to pressure overload. Proceedings of the National Academy of Sciences of the United States of America. 94: 7543-8. PMID 9207128 DOI: 10.1073/Pnas.94.14.7543  0.429
1997 Molkentin JD, Lin Q, Duncan SA, Olson EN. Requirement of the transcription factor GATA4 for heart tube formation and ventral morphogenesis. Genes & Development. 11: 1061-72. PMID 9136933 DOI: 10.1101/Gad.11.8.1061  0.56
1996 Molkentin JD, Olson EN. Defining the regulatory networks for muscle development. Current Opinion in Genetics & Development. 6: 445-53. PMID 8791524 DOI: 10.1016/S0959-437X(96)80066-9  0.497
1996 Molkentin JD, Olson EN. Combinatorial control of muscle development by basic helix-loop-helix and MADS-box transcription factors. Proceedings of the National Academy of Sciences of the United States of America. 93: 9366-73. PMID 8790335 DOI: 10.1073/Pnas.93.18.9366  0.522
1996 Molkentin JD, Jobe SM, Markham BE. Alpha-myosin heavy chain gene regulation: delineation and characterization of the cardiac muscle-specific enhancer and muscle-specific promoter. Journal of Molecular and Cellular Cardiology. 28: 1211-25. PMID 8782063 DOI: 10.1006/Jmcc.1996.0112  0.423
1996 Molkentin JD, Firulli AB, Black BL, Martin JF, Hustad CM, Copeland N, Jenkins N, Lyons G, Olson EN. MEF2B is a potent transactivator expressed in early myogenic lineages Molecular and Cellular Biology. 16: 3814-3824. PMID 8668199 DOI: 10.1128/Mcb.16.7.3814  0.765
1996 Molkentin JD, Li L, Olson EN. Phosphorylation of the MADS-Box transcription factor MEF2C enhances its DNA binding activity. The Journal of Biological Chemistry. 271: 17199-204. PMID 8663403 DOI: 10.1074/Jbc.271.29.17199  0.477
1996 Molkentin JD, Black BL, Martin JF, Olson EN. Mutational analysis of the DNA binding, dimerization, and transcriptional activation domains of MEF2C. Molecular and Cellular Biology. 16: 2627-36. PMID 8649370 DOI: 10.1128/Mcb.16.6.2627  0.67
1995 Molkentin JD, Black BL, Martin JF, Olson EN. Cooperative activation of muscle gene expression by MEF2 and myogenic bHLH proteins. Cell. 83: 1125-36. PMID 8548800 DOI: 10.1016/0092-8674(95)90139-6  0.719
1995 Ranganayakulu G, Zhao B, Dokidis A, Molkentin JD, Olson EN, Schulz RA. A series of mutations in the D-MEF2 transcription factor reveal multiple functions in larval and adult myogenesis in Drosophila. Developmental Biology. 171: 169-81. PMID 7556894 DOI: 10.1006/Dbio.1995.1269  0.505
1994 Molkentin JD, Markham BE. An M-CAT binding factor and an RSRF-related A-rich binding factor positively regulate expression of the alpha-cardiac myosin heavy-chain gene in vivo. Molecular and Cellular Biology. 14: 5056-65. PMID 8035789 DOI: 10.1128/Mcb.14.8.5056  0.417
1994 Molkentin JD, Kalvakolanu DV, Markham BE. Transcription factor GATA-4 regulates cardiac muscle-specific expression of the alpha-myosin heavy-chain gene. Molecular and Cellular Biology. 14: 4947-57. PMID 8007990 DOI: 10.1128/Mcb.14.7.4947  0.406
Low-probability matches (unlikely to be authored by this person)
2009 Konopatskaya O, Gilio K, Harper MT, Zhao Y, Cosemans JM, Karim ZA, Whiteheart SW, Molkentin JD, Verkade P, Watson SP, Heemskerk JW, Poole AW. PKCalpha regulates platelet granule secretion and thrombus formation in mice. The Journal of Clinical Investigation. 119: 399-407. PMID 19147982 DOI: 10.1172/Jci34665  0.3
2020 Hortells L, Valiente-Alandi I, Thomas ZM, Agnew EJ, Schnell DJ, York AJ, Vagnozzi RJ, Meyer EC, Molkentin JD, Yutzey KE. A specialized population of Periostin-expressing cardiac fibroblasts contributes to postnatal cardiomyocyte maturation and innervation. Proceedings of the National Academy of Sciences of the United States of America. PMID 32817558 DOI: 10.1073/pnas.2009119117  0.298
2006 Sahin B, Shu H, Fernandez J, El-Armouche A, Molkentin JD, Nairn AC, Bibb JA. Phosphorylation of protein phosphatase inhibitor-1 by protein kinase C. The Journal of Biological Chemistry. 281: 24322-35. PMID 16772299 DOI: 10.1074/Jbc.M603282200  0.296
2016 Cunha DA, Cito M, Carlsson PO, Vanderwinden JM, Molkentin JD, Bugliani M, Marchetti P, Eizirik DL, Cnop M. Thrombospondin 1 protects pancreatic β-cells from lipotoxicity via the PERK-NRF2 pathway. Cell Death and Differentiation. PMID 27588705 DOI: 10.1038/Cdd.2016.89  0.296
2014 Karch J, Molkentin JD. Identifying the components of the elusive mitochondrial permeability transition pore. Proceedings of the National Academy of Sciences of the United States of America. 111: 10396-7. PMID 25002521 DOI: 10.1073/Pnas.1410104111  0.296
2014 Taddeo EP, Laker RC, Breen DS, Akhtar YN, Kenwood BM, Liao JA, Zhang M, Fazakerley DJ, Tomsig JL, Harris TE, Keller SR, Chow JD, Lynch KR, Chokki M, Molkentin JD, et al. Opening of the mitochondrial permeability transition pore links mitochondrial dysfunction to insulin resistance in skeletal muscle. Molecular Metabolism. 3: 124-34. PMID 24634818 DOI: 10.1016/J.Molmet.2013.11.003  0.295
2010 Navedo MF, Takeda Y, Nieves-Cintrón M, Molkentin JD, Santana LF. Elevated Ca2+ sparklet activity during acute hyperglycemia and diabetes in cerebral arterial smooth muscle cells. American Journal of Physiology. Cell Physiology. 298: C211-20. PMID 19846755 DOI: 10.1152/Ajpcell.00267.2009  0.295
2005 Nimah M, Zhao B, Denenberg AG, Bueno O, Molkentin J, Wong HR, Shanley TP. Contribution of MKP-1 regulation of p38 to endotoxin tolerance. Shock (Augusta, Ga.). 23: 80-7. PMID 15614136 DOI: 10.1097/01.Shk.0000145206.28812.60  0.295
2007 Xiong D, Yajima T, Lim BK, Stenbit A, Dublin A, Dalton ND, Summers-Torres D, Molkentin JD, Duplain H, Wessely R, Chen J, Knowlton KU. Inducible cardiac-restricted expression of enteroviral protease 2A is sufficient to induce dilated cardiomyopathy. Circulation. 115: 94-102. PMID 17190866 DOI: 10.1161/Circulationaha.106.631093  0.295
2004 Moz Y, Levi R, Lavi-Moshayoff V, Cox KB, Molkentin JD, Silver J, Naveh-Many T. Calcineurin Abeta is central to the expression of the renal type II Na/Pi co-transporter gene and to the regulation of renal phosphate transport. Journal of the American Society of Nephrology : Jasn. 15: 2972-80. PMID 15579499 DOI: 10.1097/01.Asn.0000144207.44469.Be  0.295
2006 Navedo MF, Amberg GC, Nieves M, Molkentin JD, Santana LF. Mechanisms underlying heterogeneous Ca2+ sparklet activity in arterial smooth muscle. The Journal of General Physiology. 127: 611-22. PMID 16702354 DOI: 10.1085/Jgp.200609519  0.295
2010 Harper MT, Molkentin JD, Poole AW. Protein kinase C alpha enhances sodium-calcium exchange during store-operated calcium entry in mouse platelets. Cell Calcium. 48: 333-40. PMID 21094527 DOI: 10.1016/J.Ceca.2010.10.006  0.29
2005 Pope SM, Fulkerson PC, Blanchard C, Akei HS, Nikolaidis NM, Zimmermann N, Molkentin JD, Rothenberg ME. Identification of a cooperative mechanism involving interleukin-13 and eotaxin-2 in experimental allergic lung inflammation. The Journal of Biological Chemistry. 280: 13952-61. PMID 15647285 DOI: 10.1074/Jbc.M406037200  0.289
2002 Kassiri Z, Zobel C, Nguyen TT, Molkentin JD, Backx PH. Reduction of I(to) causes hypertrophy in neonatal rat ventricular myocytes. Circulation Research. 90: 578-85. PMID 11909822 DOI: 10.1161/01.Res.0000012223.86441.A1  0.289
2004 Nimah M, Zhao B, Bueno O, Molkentin J, Shanley T. ENDOTOXIN TOLERANCE IS MEDIATED BY MKP-1 REGULATION OF THE p38 KINASE. Shock. 21: 22. DOI: 10.1097/00024382-200406002-00064  0.288
2011 Sugden PH, Markou T, Fuller SJ, Tham EL, Molkentin JD, Paterson HF, Clerk A. Corrigendum to "Monophosphothreonyl extracellular signal-regulated kinases 1 and 2 (ERK1/2) are formed endogenously in intact cardiac myocytes and are enzymically active" [Cell Signal 23 (2011) 468-477] Cellular Signalling. 23: 950. DOI: 10.1016/J.Cellsig.2011.01.011  0.288
2009 DeSantiago J, Zima AV, Domeier TL, Ginsburg K, Molkentin JD, Blatter LA, Bers DM. IP3 Receptor-mediated Ca Release Facilitates RyR-Ca Release To Cause Inotropy And Arrhythmogenicity In Mouse Ventricular Myocytes Biophysical Journal. 96: 540a. DOI: 10.1016/J.Bpj.2008.12.2790  0.288
2015 Mukherjee R, Mareninova OA, Odinokova IV, Huang W, Murphy J, Chvanov M, Javed MA, Wen L, Booth DM, Cane MC, Awais M, Gavillet B, Pruss RM, Schaller S, Molkentin JD, et al. Mechanism of mitochondrial permeability transition pore induction and damage in the pancreas: inhibition prevents acute pancreatitis by protecting production of ATP. Gut. PMID 26071131 DOI: 10.1136/Gutjnl-2014-308553  0.287
2007 Oka T, Kaiser RA, Melendez J, Molkentin JD. Genetic Manipulation of Periostin Expression Reveals a Role in Cardiac Hypertrophy and Ventricular Remodeling Journal of Cardiac Failure. 13: S51. DOI: 10.1016/J.CARDFAIL.2007.06.236  0.286
2023 Bround MJ, Havens JR, York AJ, Sargent MA, Karch J, Molkentin JD. ANT-dependent MPTP underlies necrotic myofiber death in muscular dystrophy. Science Advances. 9: eadi2767. PMID 37624892 DOI: 10.1126/sciadv.adi2767  0.283
2008 Du H, Guo L, Fang F, Chen D, Sosunov AA, McKhann GM, Yan Y, Wang C, Zhang H, Molkentin JD, Gunn-Moore FJ, Vonsattel JP, Arancio O, Chen JX, Yan SD. Cyclophilin D deficiency attenuates mitochondrial and neuronal perturbation and ameliorates learning and memory in Alzheimer's disease. Nature Medicine. 14: 1097-105. PMID 18806802 DOI: 10.1038/Nm.1868  0.283
2016 Vanhoutte D, Schips TG, Kwong JQ, Davis J, Tjondrokoesoemo A, Brody MJ, Sargent MA, Kanisicak O, Yi H, Gao QQ, Rabinowitz JE, Volk T, McNally EM, Molkentin JD. Author response: Thrombospondin expression in myofibers stabilizes muscle membranes Elife. DOI: 10.7554/Elife.17589.028  0.281
2006 Jobe SM, Wilson KM, Leo L, Molkentin JD, Lentz SR, Di Paola J. Critical Role for Cyclophilin D and the Mitochondrial Permeability Transition Pore (MPTP) in Platelet Activation. Blood. 108: 1508-1508. DOI: 10.1182/Blood.V108.11.1508.1508  0.279
2007 Amberg GC, Navedo MF, Nieves-Cintrón M, Molkentin JD, Santana LF. Calcium sparklets regulate local and global calcium in murine arterial smooth muscle. The Journal of Physiology. 579: 187-201. PMID 17158168 DOI: 10.1113/Jphysiol.2006.124420  0.276
2018 Amanakis G, Sun J, Boylston J, Liu C, Molkentin J, Murphy E. Abstract 287: Cardioprotection in Mice With a Knock-in Mutation (C202S) in Cyclophilin D Circulation Research. 123. DOI: 10.1161/Res.123.Suppl_1.287  0.275
2010 Navedo MF, Cheng EP, Yuan C, Votaw S, Molkentin JD, Scott JD, Santana LF. Increased coupled gating of L-type Ca2+ channels during hypertension and Timothy syndrome. Circulation Research. 106: 748-56. PMID 20110531 DOI: 10.1161/Circresaha.109.213363  0.275
2023 Bowers SLK, Meng Q, Kuwabara Y, Huo J, Minerath R, York AJ, Sargent MA, Prasad V, Saviola AJ, Galindo DC, Hansen KC, Vagnozzi RJ, Yutzey KE, Molkentin JD. -Deleted Mice Have Defective Type I Collagen and Secondary Reactive Cardiac Fibrosis with Altered Hypertrophic Dynamics. Cells. 12. PMID 37681905 DOI: 10.3390/cells12172174  0.272
2020 Weinberger T, Esfandyari D, Messerer D, Percin G, Schleifer C, Thaler R, Liu L, Stremmel C, Schneider V, Vagnozzi RJ, Schwanenkamp J, Fischer M, Busch K, Klapproth K, Ishikawa-Ankerhold H, ... ... Molkentin JD, et al. Ontogeny of arterial macrophages defines their functions in homeostasis and inflammation. Nature Communications. 11: 4549. PMID 32917889 DOI: 10.1038/S41467-020-18287-X  0.272
2004 Matsuura K, Wada H, Nagai T, Iijima Y, Minamino T, Sano M, Akazawa H, Molkentin JD, Kasanuki H, Komuro I. Correction: Cardiomyocytes fuse with surrounding noncardiomyocytes and reenter the cell cycle Journal of Cell Biology. 167: 985-985. DOI: 10.1083/Jcb.200312111111904C  0.271
2021 Vagnozzi RJ, Kasam RK, Sargent MA, Molkentin JD. Cardiac Cell Therapy Fails to Rejuvenate the Chronically Scarred Rodent Heart. Circulation. 144: 328-331. PMID 34310160 DOI: 10.1161/CIRCULATIONAHA.120.053080  0.269
2020 Razin T, Melamed-Book N, Argaman J, Galin I, Lowy Y, Anuka E, Naftali-Shani N, Kandel-Kfir M, Garfinkel BP, Brielle S, Granot Z, Apte RN, Conway SJ, Molkentin JD, Kamari Y, et al. Interleukin-1α dependent survival of cardiac fibroblasts is associated with StAR/STARD1 expression and improved cardiac remodeling and function after myocardial infarction. Journal of Molecular and Cellular Cardiology. PMID 33130150 DOI: 10.1016/j.yjmcc.2020.10.013  0.268
2003 Haq S, Kilter H, Michael A, Tao J, O'Leary E, Sun XM, Walters B, Bhattacharya K, Chen X, Cui L, Andreucci M, Rosenzweig A, Guerrero JL, Patten R, Liao R, ... Molkentin J, et al. Erratum: Deletion of cytosolic phospholipase A2 promotes striated muscle growth Nature Medicine. 9: 1221-1221. DOI: 10.1038/Nm0903-1221C  0.266
2022 Molkentin JD, Leinwand LA. Remembering Jeff Robbins: The Father of Cardiac Transgenesis. Jacc. Basic to Translational Science. 7: 1063-1065. PMID 36337923 DOI: 10.1016/j.jacbts.2022.09.005  0.265
2002 Lynch RA, Wagoner L, Li S, Sparks L, Molkentin J, Dorn GW. Novel and nondetected human signaling protein polymorphisms Physiol Genomics. 10: 159-168. PMID 12209018 DOI: 10.1152/Physiolgenomics.00030.2002  0.264
2015 Karch J, Kanisicak O, Brody MJ, Sargent MA, Michael DM, Molkentin JD. The necroptotic pathway and mitochondrial involvement. Plos One. DOI: 10.1371/Journal.Pone.0130520.G005  0.263
2019 Wang Y, Pandey RN, York AJ, Mallela J, Nichols WC, Hu YC, Molkentin JD, Wikenheiser-Brokamp KA, Hegde RS. The EYA3 tyrosine phosphatase activity promotes pulmonary vascular remodeling in pulmonary arterial hypertension. Nature Communications. 10: 4143. PMID 31515519 DOI: 10.1038/S41467-019-12226-1  0.26
2017 Karch J, Schips TG, Maliken BD, Brody MJ, Sargent MA, Kanisicak O, Molkentin JD. Author response: Autophagic cell death is dependent on lysosomal membrane permeability through Bax and Bak Elife. DOI: 10.7554/Elife.30543.016  0.259
2016 Zhu X, Hogan SP, Molkentin JD, Zimmermann N. Cyclophilin D Regulates Necrosis But Not Apoptosis of Murine Eosinophils. American Journal of Physiology. Gastrointestinal and Liver Physiology. ajpgi.00389.2015. PMID 26893161 DOI: 10.1152/Ajpgi.00389.2015  0.257
2011 Froese N, Kattih B, Breitbart A, Grund A, Geffers R, Molkentin JD, Kispert A, Wollert KC, Drexler H, Heineke J. GATA6 promotes angiogenic function and survival in endothelial cells by suppression of autocrine transforming growth factor beta/activin receptor-like kinase 5 signaling. The Journal of Biological Chemistry. 286: 5680-90. PMID 21127043 DOI: 10.1074/jbc.M110.176925  0.256
2022 Wintzinger M, Panta M, Miz K, Prabakaran AD, Durumutla HB, Sargent M, Peek CB, Bass J, Molkentin JD, Quattrocelli M. Impact of circadian time of dosing on cardiomyocyte-autonomous effects of glucocorticoids. Molecular Metabolism. 101528. PMID 35717025 DOI: 10.1016/j.molmet.2022.101528  0.253
2017 Nyamandi V, García-Patiño M, Molkentin J, Macleod K. Cardiac-specific Deletion of RhoA Restores Cardiac Function in a Mouse Model of Type 1 Diabetes Journal of Pharmacological and Toxicological Methods. 88: 174. DOI: 10.1016/j.vascn.2017.09.022  0.253
2009 Zhang H, Chen X, Gao E, Macdonnell S, Jaleel N, Harris DM, Nakayama H, Zhang X, Li Y, Tang M, Berretta R, Koch WJ, Molkentin JD, Houser SR. Increasing Cardiac Contractility after Myocardial Infarction Exacerbates Cardiac Injury and Pump Dysfunction Biophysical Journal. 96: 258a. DOI: 10.1016/j.bpj.2008.12.1276  0.248
2015 Liu R, Correll RN, Davis J, Vagnozzi RJ, York AJ, Sargent MA, Nairn AC, Molkentin JD. Cardiac-specific deletion of protein phosphatase 1β promotes increased myofilament protein phosphorylation and contractile alterations Journal of Molecular and Cellular Cardiology. 87: 204-213. DOI: 10.1016/j.yjmcc.2015.08.018  0.248
2023 Huo J, Prasad V, Grimes KM, Vanhoutte D, Blair NS, Lin SC, Bround MJ, Bers DM, Molkentin JD. MCUb is an inducible regulator of calcium-dependent mitochondrial metabolism and substrate utilization in muscle. Cell Reports. 42: 113465. PMID 37976157 DOI: 10.1016/j.celrep.2023.113465  0.248
1992 Barbieri JT, Armellini D, Molkentin J, Rappuoli R. Construction of a diphtheria toxin A fragment-C180 peptide fusion protein which elicits a neutralizing antibody response against diphtheria toxin and pertussis toxin Infection and Immunity. 60: 5071-5077. PMID 1452339 DOI: 10.1128/Iai.60.12.5071-5077.1992  0.244
2018 Stremmel C, Schuchert R, Wagner F, Thaler R, Weinberger T, Pick R, Mass E, Ishikawa-Ankerhold HC, Margraf A, Hutter S, Vagnozzi R, Klapproth S, Frampton J, Yona S, Scheiermann C, ... Molkentin JD, et al. Yolk sac macrophage progenitors traffic to the embryo during defined stages of development. Nature Communications. 9: 75. PMID 29311541 DOI: 10.1038/S41467-017-02492-2  0.24
2018 Karch J, Bround MJ, Parks RJ, Terada N, Wallace DC, Murphy E, Molkentin JD. Abstract 486: Role of the Adenine Nucleotide Translocator Family in the Mitochondrial Permeability Transition Pore Circulation Research. 123. DOI: 10.1161/Res.123.Suppl_1.486  0.238
2020 Vagnozzi RJ, Molkentin JD. Resident macrophages keep mitochondria running in the heart. Cell Research. PMID 33139923 DOI: 10.1038/s41422-020-00427-z  0.23
2008 Blanchard C, Mingler MK, Collins MH, Putnam PE, Molkentin JD, Rothenberg ME. 725 Periostin Facilitates Eosinophil Tissue Infiltration In Vivo and In Vitro Gastroenterology. 134: A-104. DOI: 10.1016/S0016-5085(08)60487-4  0.228
1999 Molkentin J. Bioactive lipids naturally occurring in bovine milk. Nahrung-Food. 43: 185-189. PMID 10399352 DOI: 10.1002/(Sici)1521-3803(19990601)43:3<185::Aid-Food185>3.0.Co;2-V  0.227
2022 Boyer JG, Huo J, Han S, Havens JR, Prasad V, Lin BL, Kass DA, Song T, Sadayappan S, Khairallah RJ, Ward CW, Molkentin JD. Depletion of skeletal muscle satellite cells attenuates pathology in muscular dystrophy. Nature Communications. 13: 2940. PMID 35618700 DOI: 10.1038/s41467-022-30619-7  0.226
1995 Precht D, Molkentin J. Trans fatty acids: Implications for health, analytical methods, incidence in edible fats and intake Nahrung-Food. 39: 343-374. PMID 8569844 DOI: 10.1002/Food.19950390503  0.222
2001 Qiao L, Studer E, Leach K, McKinstry R, Gupta S, Decker R, Kukreja R, Valerie K, Nagarkatti P, El Deiry W, Molkentin J, Schmidt-Ullrich R, Fisher PB, Grant S, Hylemon PB, et al. Deoxycholic acid (DCA) causes ligand-independent activation of epidermal growth factor receptor (EGFR) and FAS receptor in primary hepatocytes: Inhibition of EGFR/mitogen-activated protein kinase-signaling module enhances DCA-induced apoptosis Molecular Biology of the Cell. 12: 2629-2645. PMID 11553704 DOI: 10.1091/Mbc.12.9.2629  0.218
2019 Amanakis G, Sun J, Brody M, Bauer T, McGinty S, Boylston J, Liu C, Molkentin J, Murphy E. Abstract 295: Cysteine 202 of Cyclophilin D is a Site of Multiple Post-translational Modifications and Plays a Role in Cardioprotection Circulation Research. 125. DOI: 10.1161/Res.125.Suppl_1.295  0.218
1991 Molkentin J, Gorski J, Baxter-Lowe LA. Detection of 14 HLA-DQB1 alleles by oligotyping. Human Immunology. 31: 114-22. PMID 2066271 DOI: 10.1016/0198-8859(91)90014-Z  0.217
2010 Dzau VJ, Molkentin JD. Helmut Drexler, MD, 1951-2009. Circulation. 120: 2402-3. PMID 20050129 DOI: 10.1161/Circulationaha.109.917120  0.21
2009 Yang YJ, Chen W, Edgar A, Li B, Molkentin JD, Berman JN, Lin T. Rcan1 negatively regulates FceRI-mediated signaling and mast cell function The Journal of Cell Biology. 184: i2-i2. DOI: 10.1083/JCB1841OIA2  0.199
2017 Klir Z, Castro-Montoya JM, Novoselec J, Molkentin J, Domacinovic M, Mioc B, Dickhoefer U, Antunovic Z. Influence of pumpkin seed cake and extruded linseed on milk production and milk fatty acid profile in Alpine goats. Animal. 11: 1772-1778. PMID 28367773 DOI: 10.1017/S175173111700060X  0.197
1997 Precht D, Molkentin J. Effect of feeding on conjugated cis delta 9, trans delta 11-octadecadienoic acid and other isomers of linoleic acid in bovine milk fats. Nahrung-Food. 41: 330-335. PMID 9499182 DOI: 10.1002/Food.19970410603  0.196
2018 Stremmel C, Schuchert R, Wagner F, Thaler R, Weinberger T, Pick R, Mass E, Ishikawa-Ankerhold HC, Margraf A, Hutter S, Vagnozzi R, Klapproth S, Frampton J, Yona S, Scheiermann C, ... Molkentin JD, et al. Author Correction: Yolk sac macrophage progenitors traffic to the embryo during defined stages of development. Nature Communications. 9: 3699. PMID 30194428 DOI: 10.1038/S41467-018-06065-9  0.193
1993 Molkentin J, Gregersen PK, Lin X, Zhu N, Wang Y, Wang Y, Chen S, Chen S, Baxter-Lowe LA, Silver J. Molecular analysis of HLA-DR beta and DQ beta polymorphism in Chinese with rheumatoid arthritis. Annals of the Rheumatic Diseases. 52: 610-2. PMID 8215626 DOI: 10.1136/Ard.52.8.610  0.191
2010 Sabir H, Nehlin J, Isa A, Barington T, Kim J, Bommireddy R, Chen D, Gard C, Molkentin JD, Rimsza L, Doetschman T, Loh Y, Gracey D, Groth BFDS, Shibasaki S, et al. Organ transplantation (WS-076) Chairpersons: Susumu Ikehara, Jorge Kalil International Immunology. 22. DOI: 10.1093/Intimm/Dxq327  0.181
2018 van Berlo JH, Kanisicak O, Maillet M, Vagnozzi RJ, Karch J, Lin SJ, Middleton RC, Marbán E, Molkentin JD. van Berlo et al. reply. Nature. 555: E18. PMID 29565361 DOI: 10.1038/Nature25772  0.175
2015 Gainutdinov T, Molkentin JD, Siemen D, Ziemer M, Debska-Vielhaber G, Vielhaber S, Gizatullina Z, Orynbayeva Z, Gellerich FN. Knockout of cyclophilin D in Ppif⁻/⁻ mice increases stability of brain mitochondria against Ca²⁺ stress. Archives of Biochemistry and Biophysics. 579: 40-6. PMID 26032335 DOI: 10.1016/j.abb.2015.05.009  0.174
2022 Prasad V, Molkentin JD. At the Brink of Human Therapy to Generate New Myocytes in the Adult Injured Heart. Circulation. 145: 1356-1358. PMID 35467953 DOI: 10.1161/CIRCULATIONAHA.122.059106  0.172
2014 Khatlani T, Pradhan S, Da Q, Gushiken FC, Bergeron AL, Langlois KW, Molkentin JD, Rumbaut RE, Vijayan KV. The β isoform of the catalytic subunit of protein phosphatase 2B restrains platelet function by suppressing outside-in αII b β3 integrin signaling. Journal of Thrombosis and Haemostasis : Jth. 12: 2089-101. PMID 25330904 DOI: 10.1111/jth.12761  0.169
2022 Wintzinger M, Miz K, York A, Demonbreun AR, Molkentin JD, McNally EM, Quattrocelli M. Effects of Glucocorticoids in Murine Models of Duchenne and Limb-Girdle Muscular Dystrophy. Methods in Molecular Biology (Clifton, N.J.). 2587: 467-478. PMID 36401044 DOI: 10.1007/978-1-0716-2772-3_24  0.167
2021 Sun F, Wang G, Pradhan A, Xu K, Gomez-Arroyo J, Zhang Y, Kalin GT, Deng Z, Vagnozzi RJ, He H, Dunn AW, Wang Y, York AJ, Hegde RS, Woods JC, ... ... Molkentin JD, et al. Nanoparticle Delivery of STAT3 Alleviates Pulmonary Hypertension in a Mouse Model of Alveolar Capillary Dysplasia. Circulation. PMID 34111939 DOI: 10.1161/CIRCULATIONAHA.121.053980  0.151
2023 Florens N, Kasam RK, Rudman-Melnick V, Lin SC, Prasad V, Molkentin JD. Interleukin-33 Mediates Cardiomyopathy After Acute Kidney Injury by Signaling to Cardiomyocytes. Circulation. PMID 36695175 DOI: 10.1161/CIRCULATIONAHA.122.063014  0.135
2018 Hu R, Morley MP, Brandimarto J, Tucker NR, Parsons VA, Zhao SD, Meder B, Katus HA, Rühle F, Stoll M, Villard E, Cambien F, Lin H, Smith NL, Felix JF, ... ... Molkentin JD, et al. Genetic Reduction in Left Ventricular Protein Kinase C-α and Adverse Ventricular Remodeling in Human Subjects. Circulation. Genomic and Precision Medicine. 11: e001901. PMID 29540468 DOI: 10.1161/Circgen.117.001901  0.132
2002 Donelan MJ, Morfini G, Julyan R, Sommers S, Hays L, Kajio H, Briaud I, Easom RA, Molkentin JD, Brady ST, Rhodes CJ. Ca2+-dependent dephosphorylation of kinesin heavy chain on beta-granules in pancreatic beta-cells. Implications for regulated beta-granule transport and insulin exocytosis. The Journal of Biological Chemistry. 277: 24232-42. PMID 11978799 DOI: 10.1074/jbc.M203345200  0.127
2024 Bround MJ, Abay E, Huo J, Havens JR, York AJ, Bers DM, Molkentin JD. MCU-independent Ca uptake mediates mitochondrial Ca overload and necrotic cell death in a mouse model of Duchenne muscular dystrophy. Scientific Reports. 14: 6751. PMID 38514795 DOI: 10.1038/s41598-024-57340-3  0.12
2023 Grimes KM, Maillet M, Swoboda CO, Bowers SLK, Millay DP, Molkentin JD. MEK1-ERK1/2 signaling regulates the cardiomyocyte non-sarcomeric actin cytoskeletal network. American Journal of Physiology. Heart and Circulatory Physiology. 326: H180-H189. PMID 37999644 DOI: 10.1152/ajpheart.00612.2023  0.12
2022 Zampese E, Wokosin DL, Gonzalez-Rodriguez P, Guzman JN, Tkatch T, Kondapalli J, Surmeier WC, D'Alessandro KB, De Stefani D, Rizzuto R, Iino M, Molkentin JD, Chandel NS, Schumacker PT, Surmeier DJ. Ca channels couple spiking to mitochondrial metabolism in substantia nigra dopaminergic neurons. Science Advances. 8: eabp8701. PMID 36179023 DOI: 10.1126/sciadv.abp8701  0.117
2021 Davis G, York AJ, Bacon WC, Lin SC, McNeal MM, Yarawsky AE, Maciag JJ, Miller JLC, Locker KCS, Bailey M, Stone R, Hall M, Gonzalez J, Sproles A, Woodle ES, ... ... Molkentin JD, et al. Seroprevalence of SARS-CoV-2 infection in Cincinnati Ohio USA from August to December 2020. Plos One. 16: e0254667. PMID 34260645 DOI: 10.1371/journal.pone.0254667  0.04
1997 Molkentin JD. Book Review Exploring Genetic Mechanisms Edited by Maxine Singer and Paul Berg. 674 pp., illustrated. Sausalito, Calif., University Science Books, 1997. $86.50. 0-935702-70-9 New England Journal of Medicine. 337: 1399-1400. DOI: 10.1056/NEJM199711063371922  0.04
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