Lorne J. Hofseth - Publications

Affiliations: 
Pharmaceutical Science University of South Carolina, Columbia, SC 
Area:
Cell Biology, Pharmacology

43 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Chumanevich AA, Chaparala A, Witalison EE, Tashkandi H, Hofseth AB, Lane C, Pena E, Liu P, Pittman DL, Nagarkatti P, Nagarkatti M, Hofseth LJ, Chumanevich AA. Looking for the best anti-colitis medicine: A comparative analysis of current and prospective compounds. Oncotarget. PMID 27974688 DOI: 10.18632/oncotarget.13894  0.32
2016 Chumanevich AA, Witalison EE, Chaparala A, Chumanevich A, Nagarkatti P, Nagarkatti M, Hofseth LJ. Repurposing the anti-malarial drug, quinacrine: new anti-colitis properties. Oncotarget. PMID 27447967 DOI: 10.18632/oncotarget.10608  0.32
2015 Witalison EE, Cui X, Causey CP, Thompson PR, Hofseth LJ. Molecular targeting of protein arginine deiminases to suppress colitis and prevent colon cancer. Oncotarget. PMID 26440311 DOI: 10.18632/oncotarget.5937  0.32
2015 Samadi AK, Bilsland A, Georgakilas AG, Amedei A, Amin A, Bishayee A, Azmi AS, Lokeshwar BL, Grue B, Panis C, Boosani CS, Poudyal D, Stafforini DM, Bhakta D, Niccolai E, ... ... Hofseth LJ, et al. A multi-targeted approach to suppress tumor-promoting inflammation. Seminars in Cancer Biology. PMID 25951989 DOI: 10.1016/j.semcancer.2015.03.006  0.32
2015 Witalison EE, Thompson PR, Hofseth LJ. Protein Arginine Deiminases and Associated Citrullination: Physiological Functions and Diseases Associated with Dysregulation. Current Drug Targets. PMID 25642720  0.32
2015 Witalison EE, Cui X, Hofseth AB, Subramanian V, Causey CP, Thompson PR, Hofseth LJ. Inhibiting protein arginine deiminases has antioxidant consequences. The Journal of Pharmacology and Experimental Therapeutics. 353: 64-70. PMID 25635139 DOI: 10.1124/jpet.115.222745  0.32
2013 Poudyal D, Cui X, Le PM, Hofseth AB, Windust A, Nagarkatti M, Nagarkatti PS, Schetter AJ, Harris CC, Hofseth LJ. A key role of microRNA-29b for the suppression of colon cancer cell migration by American ginseng. Plos One. 8: e75034. PMID 24130681 DOI: 10.1371/journal.pone.0075034  0.32
2013 Cui X, Witalison EE, Chumanevich AP, Chumanevich AA, Poudyal D, Subramanian V, Schetter AJ, Harris CC, Thompson PR, Hofseth LJ. The induction of microRNA-16 in colon cancer cells by protein arginine deiminase inhibition causes a p53-dependent cell cycle arrest. Plos One. 8: e53791. PMID 23308284 DOI: 10.1371/journal.pone.0053791  0.32
2012 Bicker KL, Anguish L, Chumanevich AA, Cameron MD, Cui X, Witalison E, Subramanian V, Zhang X, Chumanevich AP, Hofseth LJ, Coonrod SA, Thompson PR. D-amino acid based protein arginine deiminase inhibitors: Synthesis, pharmacokinetics, and in cellulo efficacy. Acs Medicinal Chemistry Letters. 3: 1081-1085. PMID 23420624 DOI: 10.1021/ml300288d  0.32
2012 Bicker KL, Subramanian V, Chumanevich AA, Hofseth LJ, Thompson PR. Seeing citrulline: development of a phenylglyoxal-based probe to visualize protein citrullination. Journal of the American Chemical Society. 134: 17015-8. PMID 23030787 DOI: 10.1021/ja308871v  0.32
2012 Sohn JJ, Schetter AJ, Yfantis HG, Ridnour LA, Horikawa I, Khan MA, Robles AI, Hussain SP, Goto A, Bowman ED, Hofseth LJ, Bartkova J, Bartek J, Wogan GN, Wink DA, et al. Macrophages, nitric oxide and microRNAs are associated with DNA damage response pathway and senescence in inflammatory bowel disease. Plos One. 7: e44156. PMID 22970173 DOI: 10.1371/journal.pone.0044156  0.32
2012 Poudyal D, Cui X, Mai Le P, Davis T, Hofseth AB, Jin Y, Chumanevich AA, Wargovich MJ, Nagarkatti M, Nagarkatti PS, Windust A, Hofseth LJ. A limited role of p53 on the ability of a Hexane fraction of American ginseng to suppress mouse colitis. Journal of Biomedicine & Biotechnology. 2012: 785739. PMID 22899889 DOI: 10.1155/2012/785739  0.32
2012 Shaked H, Hofseth LJ, Chumanevich A, Chumanevich AA, Wang J, Wang Y, Taniguchi K, Guma M, Shenouda S, Clevers H, Harris CC, Karin M. Chronic epithelial NF-κB activation accelerates APC loss and intestinal tumor initiation through iNOS up-regulation. Proceedings of the National Academy of Sciences of the United States of America. 109: 14007-12. PMID 22893683 DOI: 10.1073/pnas.1211509109  0.32
2012 Cui X, Jin Y, Singh UP, Chumanevich AA, Harmon B, Cavicchia P, Hofseth AB, Kotakadi V, Poudyal D, Stroud B, Volate SR, Hurley TG, Hebert JR, Hofseth LJ. Suppression of DNA damage in human peripheral blood lymphocytes by a juice concentrate: a randomized, double-blind, placebo-controlled trial. Molecular Nutrition & Food Research. 56: 666-70. PMID 22383296 DOI: 10.1002/mnfr.201100496  0.32
2012 Poudyal D, Le PM, Davis T, Hofseth AB, Chumanevich A, Chumanevich AA, Wargovich MJ, Nagarkatti M, Nagarkatti PS, Windust A, Hofseth LJ. A hexane fraction of American ginseng suppresses mouse colitis and associated colon cancer: anti-inflammatory and proapoptotic mechanisms. Cancer Prevention Research (Philadelphia, Pa.). 5: 685-96. PMID 22293630 DOI: 10.1158/1940-6207.CAPR-11-0421  0.32
2011 Causey CP, Jones JE, Slack JL, Kamei D, Jones LE, Subramanian V, Knuckley B, Ebrahimi P, Chumanevich AA, Luo Y, Hashimoto H, Sato M, Hofseth LJ, Thompson PR. The development of N-α-(2-carboxyl)benzoyl-N(5)-(2-fluoro-1-iminoethyl)-l-ornithine amide (o-F-amidine) and N-α-(2-carboxyl)benzoyl-N(5)-(2-chloro-1-iminoethyl)-l-ornithine amide (o-Cl-amidine) as second generation protein arginine deiminase (PAD) inhibitors. Journal of Medicinal Chemistry. 54: 6919-35. PMID 21882827 DOI: 10.1021/jm2008985  0.32
2011 Chumanevich AA, Causey CP, Knuckley BA, Jones JE, Poudyal D, Chumanevich AP, Davis T, Matesic LE, Thompson PR, Hofseth LJ. Suppression of colitis in mice by Cl-amidine: a novel peptidylarginine deiminase inhibitor. American Journal of Physiology. Gastrointestinal and Liver Physiology. 300: G929-38. PMID 21415415 DOI: 10.1152/ajpgi.00435.2010  0.32
2010 Chumanevich AA, Poudyal D, Cui X, Davis T, Wood PA, Smith CD, Hofseth LJ. Suppression of colitis-driven colon cancer in mice by a novel small molecule inhibitor of sphingosine kinase. Carcinogenesis. 31: 1787-93. PMID 20688834 DOI: 10.1093/carcin/bgq158  0.32
2010 Jin Y, Cui X, Singh UP, Chumanevich AA, Harmon B, Cavicchia P, Hofseth AB, Kotakadi V, Stroud B, Volate SR, Hurley TG, Hebert JR, Hofseth LJ. Systemic inflammatory load in humans is suppressed by consumption of two formulations of dried, encapsulated juice concentrate. Molecular Nutrition & Food Research. 54: 1506-14. PMID 20425759 DOI: 10.1002/mnfr.200900579  0.32
2010 Cui X, Jin Y, Hofseth AB, Pena E, Habiger J, Chumanevich A, Poudyal D, Nagarkatti M, Nagarkatti PS, Singh UP, Hofseth LJ. Resveratrol suppresses colitis and colon cancer associated with colitis. Cancer Prevention Research (Philadelphia, Pa.). 3: 549-59. PMID 20332304 DOI: 10.1158/1940-6207.CAPR-09-0117  0.32
2010 Jin Y, Hofseth AB, Cui X, Windust AJ, Poudyal D, Chumanevich AA, Matesic LE, Singh NP, Nagarkatti M, Nagarkatti PS, Hofseth LJ. American ginseng suppresses colitis through p53-mediated apoptosis of inflammatory cells. Cancer Prevention Research (Philadelphia, Pa.). 3: 339-47. PMID 20179294 DOI: 10.1158/1940-6207.CAPR-09-0116  0.32
2009 Jones LE, Ying L, Hofseth AB, Jelezcova E, Sobol RW, Ambs S, Harris CC, Espey MG, Hofseth LJ, Wyatt MD. Differential effects of reactive nitrogen species on DNA base excision repair initiated by the alkyladenine DNA glycosylase. Carcinogenesis. 30: 2123-9. PMID 19864471 DOI: 10.1093/carcin/bgp256  0.32
2009 Yoshizawa K, Jelezcova E, Brown AR, Foley JF, Nyska A, Cui X, Hofseth LJ, Maronpot RM, Wilson SH, Sepulveda AR, Sobol RW. Gastrointestinal hyperplasia with altered expression of DNA polymerase beta. Plos One. 4: e6493. PMID 19654874 DOI: 10.1371/journal.pone.0006493  0.32
2008 Jin Y, Kotakadi VS, Ying L, Hofseth AB, Cui X, Wood PA, Windust A, Matesic LE, Pena EA, Chiuzan C, Singh NP, Nagarkatti M, Nagarkatti PS, Wargovich MJ, Hofseth LJ. American ginseng suppresses inflammation and DNA damage associated with mouse colitis. Carcinogenesis. 29: 2351-9. PMID 18802031 DOI: 10.1093/carcin/bgn211  0.32
2008 Hussain SP, He P, Subleski J, Hofseth LJ, Trivers GE, Mechanic L, Hofseth AB, Bernard M, Schwank J, Nguyen G, Mathe E, Djurickovic D, Haines D, Weiss J, Back T, et al. Nitric oxide is a key component in inflammation-accelerated tumorigenesis. Cancer Research. 68: 7130-6. PMID 18757428 DOI: 10.1158/0008-5472.CAN-08-0410  0.32
2008 Kotakadi VS, Jin Y, Hofseth AB, Ying L, Cui X, Volate S, Chumanevich A, Wood PA, Price RL, McNeal A, Singh UP, Singh NP, Nagarkatti M, Nagarkatti PS, Matesic LE, ... ... Hofseth LJ, et al. Ginkgo biloba extract EGb 761 has anti-inflammatory properties and ameliorates colitis in mice by driving effector T cell apoptosis. Carcinogenesis. 29: 1799-806. PMID 18567620 DOI: 10.1093/carcin/bgn143  0.32
2005 Hofseth LJ, Robles AI, Espey MG, Harris CC. Nitric oxide is a signaling molecule that regulates gene expression. Methods in Enzymology. 396: 326-40. PMID 16291242 DOI: 10.1016/S0076-6879(05)96027-8  0.32
2005 Staib F, Robles AI, Varticovski L, Wang XW, Zeeberg BR, Sirotin M, Zhurkin VB, Hofseth LJ, Hussain SP, Weinstein JN, Galle PR, Harris CC. The p53 tumor suppressor network is a key responder to microenvironmental components of chronic inflammatory stress. Cancer Research. 65: 10255-64. PMID 16288013 DOI: 10.1158/0008-5472.CAN-05-1714  0.32
2005 Ying L, Marino J, Hussain SP, Khan MA, You S, Hofseth AB, Trivers GE, Dixon DA, Harris CC, Hofseth LJ. Chronic inflammation promotes retinoblastoma protein hyperphosphorylation and E2F1 activation. Cancer Research. 65: 9132-6. PMID 16230367 DOI: 10.1158/0008-5472.CAN-05-1358  0.32
2004 Hussain SP, Trivers GE, Hofseth LJ, He P, Shaikh I, Mechanic LE, Doja S, Jiang W, Subleski J, Shorts L, Haines D, Laubach VE, Wiltrout RH, Djurickovic D, Harris CC. Nitric oxide, a mediator of inflammation, suppresses tumorigenesis. Cancer Research. 64: 6849-53. PMID 15466171 DOI: 10.1158/0008-5472.CAN-04-2201  0.32
2004 Goodman JE, Hofseth LJ, Hussain SP, Harris CC. Nitric oxide and p53 in cancer-prone chronic inflammation and oxyradical overload disease. Environmental and Molecular Mutagenesis. 44: 3-9. PMID 15199542 DOI: 10.1002/em.20024  0.32
2004 Thomas DD, Espey MG, Ridnour LA, Hofseth LJ, Mancardi D, Harris CC, Wink DA. Hypoxic inducible factor 1alpha, extracellular signal-regulated kinase, and p53 are regulated by distinct threshold concentrations of nitric oxide. Proceedings of the National Academy of Sciences of the United States of America. 101: 8894-9. PMID 15178764 DOI: 10.1073/pnas.0400453101  0.32
2004 Li CQ, Robles AI, Hanigan CL, Hofseth LJ, Trudel LJ, Harris CC, Wogan GN. Apoptotic signaling pathways induced by nitric oxide in human lymphoblastoid cells expressing wild-type or mutant p53. Cancer Research. 64: 3022-9. PMID 15126337 DOI: 10.1158/0008-5472.CAN-03-1880  0.32
2004 Hofseth LJ, Hussain SP, Harris CC. p53: 25 years after its discovery. Trends in Pharmacological Sciences. 25: 177-81. PMID 15116721 DOI: 10.1016/j.tips.2004.02.009  0.32
2004 Hussain SP, Amstad P, He P, Robles A, Lupold S, Kaneko I, Ichimiya M, Sengupta S, Mechanic L, Okamura S, Hofseth LJ, Moake M, Nagashima M, Forrester KS, Harris CC. p53-induced up-regulation of MnSOD and GPx but not catalase increases oxidative stress and apoptosis. Cancer Research. 64: 2350-6. PMID 15059885 DOI: 10.1158/0008-5472.CAN-2287-2  0.32
2004 Zurer I, Hofseth LJ, Cohen Y, Xu-Welliver M, Hussain SP, Harris CC, Rotter V. The role of p53 in base excision repair following genotoxic stress. Carcinogenesis. 25: 11-9. PMID 14555612 DOI: 10.1093/carcin/bgg186  0.32
2003 Hofseth LJ, Khan MA, Ambrose M, Nikolayeva O, Xu-Welliver M, Kartalou M, Hussain SP, Roth RB, Zhou X, Mechanic LE, Zurer I, Rotter V, Samson LD, Harris CC. The adaptive imbalance in base excision-repair enzymes generates microsatellite instability in chronic inflammation. The Journal of Clinical Investigation. 112: 1887-94. PMID 14679184 DOI: 10.1172/JCI19757  0.32
2003 Linke SP, Sengupta S, Khabie N, Jeffries BA, Buchhop S, Miska S, Henning W, Pedeux R, Wang XW, Hofseth LJ, Yang Q, Garfield SH, Stürzbecher HW, Harris CC. p53 interacts with hRAD51 and hRAD54, and directly modulates homologous recombination. Cancer Research. 63: 2596-605. PMID 12750285  0.32
2003 Hofseth LJ, Hussain SP, Wogan GN, Harris CC. Nitric oxide in cancer and chemoprevention. Free Radical Biology & Medicine. 34: 955-68. PMID 12684081 DOI: 10.1016/S0891-5849(02)01363-1  0.32
2003 Hussain SP, Hofseth LJ, Harris CC. Radical causes of cancer. Nature Reviews. Cancer. 3: 276-85. PMID 12671666 DOI: 10.1038/nrc1046  0.32
2003 Staib F, Hussain SP, Hofseth LJ, Wang XW, Harris CC. TP53 and liver carcinogenesis. Human Mutation. 21: 201-16. PMID 12619106 DOI: 10.1002/humu.10176  0.32
2003 Hofseth LJ, Saito S, Hussain SP, Espey MG, Miranda KM, Araki Y, Jhappan C, Higashimoto Y, He P, Linke SP, Quezado MM, Zurer I, Rotter V, Wink DA, Appella E, et al. Nitric oxide-induced cellular stress and p53 activation in chronic inflammation. Proceedings of the National Academy of Sciences of the United States of America. 100: 143-8. PMID 12518062 DOI: 10.1073/pnas.0237083100  0.32
2002 Wang XW, Hussain SP, Huo TI, Wu CG, Forgues M, Hofseth LJ, Brechot C, Harris CC. Molecular pathogenesis of human hepatocellular carcinoma. Toxicology. 181: 43-7. PMID 12505283  0.32
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