Alex Toker - Publications

Affiliations: 
Harvard University, Cambridge, MA, United States 
Area:
Pathology, Cell Biology, Molecular Biology

57 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any innacuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2018 Toker A, Dibble CC. PI 3-Kinase Signaling: AKTing up inside the Cell. Molecular Cell. 71: 875-876. PMID 30241602 DOI: 10.1016/j.molcel.2018.09.006  0.92
2017 Lien EC, Ghisolfi L, Geck RC, Asara JM, Toker A. Oncogenic PI3K promotes methionine dependency in breast cancer cells through the cystine-glutamate antiporter xCT. Science Signaling. 10. PMID 29259101 DOI: 10.1126/scisignal.aao6604  0.72
2017 Liu H, Murphy CJ, Karreth FA, Emdal KB, White FM, Elemento O, Toker A, Wulf GM, Cantley LC. Identifying and Targeting Sporadic Oncogenic Genetic Aberrations in Mouse Models of Triple Negative Breast Cancer. Cancer Discovery. PMID 29203461 DOI: 10.1158/2159-8290.CD-17-0679  0.6
2017 Manning BD, Toker A. AKT/PKB Signaling: Navigating the Network. Cell. 169: 381-405. PMID 28431241 DOI: 10.1016/j.cell.2017.04.001  0.36
2017 Lien EC, Dibble CC, Toker A. PI3K signaling in cancer: beyond AKT. Current Opinion in Cell Biology. 45: 62-71. PMID 28343126 DOI: 10.1016/j.ceb.2017.02.007  0.92
2017 Brown KK, Spinelli JB, Asara JM, Toker A. Adaptive Reprogramming of De Novo Pyrimidine Synthesis Is a Metabolic Vulnerability in Triple-Negative Breast Cancer. Cancer Discovery. PMID 28255083 DOI: 10.1158/2159-8290.CD-16-0611  0.36
2017 Shimizu K, Fukushima H, Ogura K, Lien EC, Nihira NT, Zhang J, North BJ, Guo A, Nagashima K, Nakagawa T, Hoshikawa S, Watahiki A, Okabe K, Yamada A, Toker A, et al. The SCFβ-TRCP E3 ubiquitin ligase complex targets Lipin1 for ubiquitination and degradation to promote hepatic lipogenesis. Science Signaling. 10. PMID 28049764 DOI: 10.1126/scisignal.aah4117  0.72
2016 Henry WS, Laszewski T, Tsang T, Beca F, Beck AH, McAllister SS, Toker A. Aspirin suppresses growth in PI3K-mutant breast cancer by activating AMPK and inhibiting mTORC1 signaling. Cancer Research. PMID 27940576 DOI: 10.1158/0008-5472.CAN-16-2400  0.36
2016 Henry WS, Hendrickson DG, Beca F, Glass B, Lindahl-Allen M, He L, Ji Z, Struhl K, Beck AH, Rinn JL, Toker A. LINC00520 is induced by Src, STAT3, and PI3K and plays a functional role in breast cancer. Oncotarget. PMID 27626181 DOI: 10.18632/oncotarget.11962  0.36
2016 Guo J, Chakraborty AA, Liu P, Gan W, Zheng X, Inuzuka H, Wang B, Zhang J, Zhang L, Yuan M, Novak J, Cheng JQ, Toker A, Signoretti S, Zhang Q, et al. pVHL suppresses kinase activity of Akt in a proline-hydroxylation-dependent manner. Science (New York, N.Y.). 353: 929-32. PMID 27563096 DOI: 10.1126/science.aad5755  0.36
2016 Zhang J, Xu K, Liu P, Geng Y, Wang B, Gan W, Guo J, Wu F, Chin YR, Berrios C, Lien EC, Toker A, DeCaprio JA, Sicinski P, Wei W. Inhibition of Rb Phosphorylation Leads to mTORC2-Mediated Activation of Akt. Molecular Cell. PMID 27237051 DOI: 10.1016/j.molcel.2016.04.023  0.96
2016 Lien EC, Lyssiotis CA, Juvekar A, Hu H, Asara JM, Cantley LC, Toker A. Glutathione biosynthesis is a metabolic vulnerability in PI(3)K/Akt-driven breast cancer. Nature Cell Biology. PMID 27088857 DOI: 10.1038/ncb3341  0.96
2016 Mancini ML, Lien EC, Toker A. Oncogenic AKT1(E17K) mutation induces mammary hyperplasia but prevents HER2-driven tumorigenesis. Oncotarget. PMID 27004402 DOI: 10.18632/oncotarget.8191  0.72
2015 Liu P, Gan W, Chin YR, Ogura K, Guo J, Zhang J, Wang B, Blenis J, Cantley LC, Toker A, Su B, Wei W. PtdIns(3,4,5)P3-Dependent Activation of the mTORC2 Kinase Complex. Cancer Discovery. 5: 1194-209. PMID 26293922 DOI: 10.1158/2159-8290.CD-15-0460  0.96
2015 Brown KK, Montaser-Kouhsari L, Beck AH, Toker A. MERIT40 Is an Akt Substrate that Promotes Resolution of DNA Damage Induced by Chemotherapy. Cell Reports. 11: 1358-66. PMID 26027929 DOI: 10.1016/j.celrep.2015.05.004  0.96
2015 Brown KK, Toker A. The phosphoinositide 3-kinase pathway and therapy resistance in cancer. F1000prime Reports. 7: 13. PMID 25750731 DOI: 10.12703/P7-13  0.96
2015 Kaunisto A, Henry WS, Montaser-Kouhsari L, Jaminet SC, Oh EY, Zhao L, Luo HR, Beck AH, Toker A. NFAT1 promotes intratumoral neutrophil infiltration by regulating IL8 expression in breast cancer. Molecular Oncology. 9: 1140-54. PMID 25735562 DOI: 10.1016/j.molonc.2015.02.004  0.96
2014 Gasser JA, Inuzuka H, Lau AW, Wei W, Beroukhim R, Toker A. SGK3 mediates INPP4B-dependent PI3K signaling in breast cancer. Molecular Cell. 56: 595-607. PMID 25458846 DOI: 10.1016/j.molcel.2014.09.023  0.96
2014 Clark AR, Toker A. Signalling specificity in the Akt pathway in breast cancer. Biochemical Society Transactions. 42: 1349-55. PMID 25233414 DOI: 10.1042/BST20140160  0.96
2014 Liu P, Begley M, Michowski W, Inuzuka H, Ginzberg M, Gao D, Tsou P, Gan W, Papa A, Kim BM, Wan L, Singh A, Zhai B, Yuan M, Wang Z, ... ... Toker A, et al. Cell-cycle-regulated activation of Akt kinase by phosphorylation at its carboxyl terminus. Nature. 508: 541-5. PMID 24670654 DOI: 10.1038/nature13079  0.96
2014 Chin YR, Yoshida T, Marusyk A, Beck AH, Polyak K, Toker A. Targeting Akt3 signaling in triple-negative breast cancer. Cancer Research. 74: 964-73. PMID 24335962 DOI: 10.1158/0008-5472.CAN-13-2175  0.96
2014 Elloul S, Kedrin D, Knoblauch NW, Beck AH, Toker A. The adherens junction protein afadin is an AKT substrate that regulates breast cancer cell migration. Molecular Cancer Research : McR. 12: 464-76. PMID 24269953 DOI: 10.1158/1541-7786.MCR-13-0398  0.36
2013 White CD, Toker A. Using phospho-motif antibodies to determine kinase substrates. Current Protocols in Molecular Biology / Edited by Frederick M. Ausubel ... [Et Al.]. Unit 18.20.. PMID 23288461 DOI: 10.1002/0471142727.mb1820s101  0.96
2013 Kazerounian S, Gerald D, Huang M, Chin YR, Udayakumar D, Zheng N, O'Donnell RK, Perruzzi C, Mangiante L, Pourat J, Phung TL, Bravo-Nuevo A, Shechter S, McNamara S, Duhadaway JB, ... ... Toker A, et al. RhoB differentially controls Akt function in tumor cells and stromal endothelial cells during breast tumorigenesis. Cancer Research. 73: 50-61. PMID 23135917 DOI: 10.1158/0008-5472.CAN-11-3055  0.96
2012 Christoforides C, Rainero E, Brown KK, Norman JC, Toker A. PKD controls αvβ3 integrin recycling and tumor cell invasive migration through its substrate Rabaptin-5. Developmental Cell. 23: 560-72. PMID 22975325 DOI: 10.1016/j.devcel.2012.08.008  0.96
2012 Inuzuka H, Gao D, Finley LW, Yang W, Wan L, Fukushima H, Chin YR, Zhai B, Shaik S, Lau AW, Wang Z, Gygi SP, Nakayama K, Teruya-Feldstein J, Toker A, et al. Acetylation-dependent regulation of Skp2 function. Cell. 150: 179-93. PMID 22770219 DOI: 10.1016/j.cell.2012.05.038  0.96
2012 Banerji S, Cibulskis K, Rangel-Escareno C, Brown KK, Carter SL, Frederick AM, Lawrence MS, Sivachenko AY, Sougnez C, Zou L, Cortes ML, Fernandez-Lopez JC, Peng S, Ardlie KG, Auclair D, ... ... Toker A, et al. Sequence analysis of mutations and translocations across breast cancer subtypes. Nature. 486: 405-9. PMID 22722202 DOI: 10.1038/nature11154  0.96
2011 Gao D, Inuzuka H, Tan MK, Fukushima H, Locasale JW, Liu P, Wan L, Zhai B, Chin YR, Shaik S, Lyssiotis CA, Gygi SP, Toker A, Cantley LC, Asara JM, et al. mTOR drives its own activation via SCF(βTrCP)-dependent degradation of the mTOR inhibitor DEPTOR. Molecular Cell. 44: 290-303. PMID 22017875 DOI: 10.1016/j.molcel.2011.08.030  0.96
2011 Yiu GK, Kaunisto A, Chin YR, Toker A. NFAT promotes carcinoma invasive migration through glypican-6. The Biochemical Journal. 440: 157-66. PMID 21871017 DOI: 10.1042/BJ20110530  0.32
2010 Gao D, Wan L, Inuzuka H, Berg AH, Tseng A, Zhai B, Shaik S, Bennett E, Tron AE, Gasser JA, Lau A, Gygi SP, Harper JW, DeCaprio JA, Toker A, et al. Rictor forms a complex with Cullin-1 to promote SGK1 ubiquitination and destruction. Molecular Cell. 39: 797-808. PMID 20832730 DOI: 10.1016/j.molcel.2010.08.016  0.96
2010 Fry JL, Toker A. Secreted and membrane-bound isoforms of protease ADAM9 have opposing effects on breast cancer cell migration. Cancer Research. 70: 8187-98. PMID 20736367 DOI: 10.1158/0008-5472.CAN-09-4231  0.96
2010 Nhek S, Ngo M, Yang X, Ng MM, Field SJ, Asara JM, Ridgway ND, Toker A. Regulation of oxysterol-binding protein Golgi localization through protein kinase D-mediated phosphorylation. Molecular Biology of the Cell. 21: 2327-37. PMID 20444975 DOI: 10.1091/mbc.E10-02-0090  0.96
2009 Maurer M, Su T, Saal LH, Koujak S, Hopkins BD, Barkley CR, Wu J, Nandula S, Dutta B, Xie Y, Chin YR, Kim DI, Ferris JS, Gruvberger-Saal SK, Laakso M, ... ... Toker A, et al. 3-Phosphoinositide-dependent kinase 1 potentiates upstream lesions on the phosphatidylinositol 3-kinase pathway in breast carcinoma. Cancer Research. 69: 6299-306. PMID 19602588 DOI: 10.1158/0008-5472.CAN-09-0820  0.96
2009 Storz P, Döppler H, Copland JA, Simpson KJ, Toker A. FOXO3a promotes tumor cell invasion through the induction of matrix metalloproteinases. Molecular and Cellular Biology. 29: 4906-17. PMID 19564415 DOI: 10.1128/MCB.00077-09  1
2009 Gao D, Inuzuka H, Tseng A, Chin RY, Toker A, Wei W. Phosphorylation by Akt1 promotes cytoplasmic localization of Skp2 and impairs APCCdh1-mediated Skp2 destruction. Nature Cell Biology. 11: 397-408. PMID 19270695 DOI: 10.1038/ncb1847  0.96
2009 Yoeli-Lerner M, Chin YR, Hansen CK, Toker A. Akt/protein kinase b and glycogen synthase kinase-3beta signaling pathway regulates cell migration through the NFAT1 transcription factor. Molecular Cancer Research : McR. 7: 425-32. PMID 19258413 DOI: 10.1158/1541-7786.MCR-08-0342  0.36
2008 Watkins JL, Lewandowski KT, Meek SE, Storz P, Toker A, Piwnica-Worms H. Phosphorylation of the Par-1 polarity kinase by protein kinase D regulates 14-3-3 binding and membrane association. Proceedings of the National Academy of Sciences of the United States of America. 105: 18378-83. PMID 19011111 DOI: 10.1073/pnas.0809661105  0.96
2007 Kunkel MT, Toker A, Tsien RY, Newton AC. Calcium-dependent regulation of protein kinase D revealed by a genetically encoded kinase activity reporter. The Journal of Biological Chemistry. 282: 6733-42. PMID 17189263 DOI: 10.1074/jbc.M608086200  0.96
2006 Toker A, Yoeli-Lerner M. Akt signaling and cancer: surviving but not moving on. Cancer Research. 66: 3963-6. PMID 16618711 DOI: 10.1158/0008-5472.CAN-06-0743  0.36
2006 Yoeli-Lerner M, Toker A. Akt/PKB signaling in cancer: a function in cell motility and invasion. Cell Cycle (Georgetown, Tex.). 5: 603-5. PMID 16582622 DOI: 10.4161/cc.5.6.2561  0.36
2006 Yiu GK, Toker A. NFAT induces breast cancer cell invasion by promoting the induction of cyclooxygenase-2. The Journal of Biological Chemistry. 281: 12210-7. PMID 16505480 DOI: 10.1074/jbc.M600184200  0.32
2005 Yoeli-Lerner M, Yiu GK, Rabinovitz I, Erhardt P, Jauliac S, Toker A. Akt blocks breast cancer cell motility and invasion through the transcription factor NFAT. Molecular Cell. 20: 539-50. PMID 16307918 DOI: 10.1016/j.molcel.2005.10.033  0.96
2005 Storz P, Döppler H, Toker A. Protein kinase D mediates mitochondrion-to-nucleus signaling and detoxification from mitochondrial reactive oxygen species. Molecular and Cellular Biology. 25: 8520-30. PMID 16166634 DOI: 10.1128/MCB.25.19.8520-8530.2005  1
2005 Hausser A, Storz P, Märtens S, Link G, Toker A, Pfizenmaier K. Protein kinase D regulates vesicular transport by phosphorylating and activating phosphatidylinositol-4 kinase IIIbeta at the Golgi complex. Nature Cell Biology. 7: 880-6. PMID 16100512 DOI: 10.1038/ncb1289  1
2005 Döppler H, Storz P, Li J, Comb MJ, Toker A. A phosphorylation state-specific antibody recognizes Hsp27, a novel substrate of protein kinase D. The Journal of Biological Chemistry. 280: 15013-9. PMID 15728188 DOI: 10.1074/jbc.C400575200  0.96
2005 Storz P, Döppler H, Ferran C, Grey ST, Toker A. Functional dichotomy of A20 in apoptotic and necrotic cell death Biochemical Journal. 387: 47-55. PMID 15527421 DOI: 10.1042/BJ20041443  0.96
2004 Hutti JE, Jarrell ET, Chang JD, Abbott DW, Storz P, Toker A, Cantley LC, Turk BE. A rapid method for determining protein kinase phosphorylation specificity. Nature Methods. 1: 27-9. PMID 15782149 DOI: 10.1038/nmeth708  1
2004 Hodges RR, Raddassi I, Zoukhri D, Toker A, Kazlauskas A, Dartt DA. Effect of overexpression of constitutively active PKCalpha on rat lacrimal gland protein secretion. Investigative Ophthalmology & Visual Science. 45: 3974-81. PMID 15505044 DOI: 10.1167/iovs.04-0508  0.96
2004 Storz P, Döppler H, Toker A. Activation loop phosphorylation controls protein kinase D-dependent activation of nuclear factor kappaB. Molecular Pharmacology. 66: 870-9. PMID 15226414 DOI: 10.1124/mol.104.000687  1
2004 Storz P, Döppler H, Toker A. Protein kinase Cdelta selectively regulates protein kinase D-dependent activation of NF-kappaB in oxidative stress signaling. Molecular and Cellular Biology. 24: 2614-26. PMID 15024053  1
2003 Storz P, Toker A. NF-kappaB signaling--an alternate pathway for oxidative stress responses. Cell Cycle (Georgetown, Tex.). 2: 9-10. PMID 12695674 DOI: 10.4161/cc.2.1.234  1
2003 Storz P, Döppler H, Johannes FJ, Toker A. Tyrosine phosphorylation of protein kinase D in the pleckstrin homology domain leads to activation. The Journal of Biological Chemistry. 278: 17969-76. PMID 12637538 DOI: 10.1074/jbc.M213224200  1
2003 Storz P, Toker A. Protein kinase D mediates a stress-induced NF-kappaB activation and survival pathway. The Embo Journal. 22: 109-20. PMID 12505989 DOI: 10.1093/emboj/cdg009  1
2002 Hodges RR, Kazlauskas A, Toker A, Dartt DA. Effect of overexpression of protein kinase C alpha on rat lacrimal gland protein secretion. Advances in Experimental Medicine and Biology. 506: 237-41. PMID 12613914  0.96
2002 Jauliac S, López-Rodriguez C, Shaw LM, Brown LF, Rao A, Toker A. The role of NFAT transcription factors in integrin-mediated carcinoma invasion. Nature Cell Biology. 4: 540-4. PMID 12080349 DOI: 10.1038/ncb816  0.36
2002 Cenni V, Döppler H, Sonnenburg ED, Maraldi N, Newton AC, Toker A. Regulation of novel protein kinase C epsilon by phosphorylation. The Biochemical Journal. 363: 537-45. PMID 11964154  1
2002 Storz P, Toker A. 3'-phosphoinositide-dependent kinase-1 (PDK-1) in PI 3-kinase signaling. Frontiers in Bioscience : a Journal and Virtual Library. 7: d886-902. PMID 11897568  1
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