Gregg Semenza - Publications

Affiliations: 
Johns Hopkins University, Baltimore, MD 
Area:
Cell Biology, Molecular Biology

105 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any innacuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2018 Bao L, Chen Y, Lai HT, Wu SY, Wang JE, Hatanpaa KJ, Raisanen JM, Fontenot M, Lega B, Chiang CM, Semenza GL, Wang Y, Luo W. Methylation of hypoxia-inducible factor (HIF)-1α by G9a/GLP inhibits HIF-1 transcriptional activity and cell migration. Nucleic Acids Research. PMID 29860315 DOI: 10.1093/nar/gky449  0.32
2017 Lu H, Chen I, Shimoda LA, Park Y, Zhang C, Tran L, Zhang H, Semenza GL. Chemotherapy-Induced Ca(2+) Release Stimulates Breast Cancer Stem Cell Enrichment. Cell Reports. 18: 1946-1957. PMID 28228260 DOI: 10.1016/j.celrep.2017.02.001  0.36
2017 Ju JA, Godet I, Ye IC, Byun J, Jayatilaka H, Lee SJ, Xiang L, Samanta D, Lee MH, Wu PH, Wirtz D, Semenza GL, Gilkes DM. Hypoxia Selectively Enhances Integrin Receptor Expression to Promote Metastasis. Molecular Cancer Research : McR. PMID 28213554 DOI: 10.1158/1541-7786.MCR-16-0338  0.48
2016 Schito L, Semenza GL. Hypoxia-Inducible Factors: Master Regulators of Cancer Progression. Trends in Cancer. 2: 758-770. PMID 28741521 DOI: 10.1016/j.trecan.2016.10.016  1
2016 Elgogary A, Xu Q, Poore B, Alt J, Zimmermann SC, Zhao L, Fu J, Chen B, Xia S, Liu Y, Neisser M, Nguyen C, Lee R, Park JK, Reyes J, ... ... Semenza GL, et al. Combination therapy with BPTES nanoparticles and metformin targets the metabolic heterogeneity of pancreatic cancer. Proceedings of the National Academy of Sciences of the United States of America. PMID 27559084 DOI: 10.1073/pnas.1611406113  1
2016 Yuan G, Peng YJ, Khan SA, Nanduri J, Singh A, Vasavda C, Semenza GL, Kumar GK, Snyder SH, Prabhakar NR. H2S production by reactive oxygen species in the carotid body triggers hypertension in a rodent model of sleep apnea. Science Signaling. 9: ra80. PMID 27531649 DOI: 10.1126/scisignal.aaf3204  1
2016 Samanta D, Park Y, Andrabi SA, Shelton LM, Gilkes DM, Semenza GL. PHGDH Expression is Required for Mitochondrial Redox Homeostasis, Breast Cancer Stem Cell Maintenance and Lung Metastasis. Cancer Research. PMID 27280394 DOI: 10.1158/0008-5472.CAN-16-0530  1
2016 Bullen JW, Tchernyshyov I, Holewinski RJ, DeVine L, Wu F, Venkatraman V, Kass DL, Cole RN, Van Eyk J, Semenza GL. Protein kinase A-dependent phosphorylation stimulates the transcriptional activity of hypoxia-inducible factor 1. Science Signaling. 9: ra56. PMID 27245613 DOI: 10.1126/scisignal.aaf0583  1
2016 Zhang C, Samanta D, Lu H, Bullen JW, Zhang H, Chen I, He X, Semenza GL. Hypoxia induces the breast cancer stem cell phenotype by HIF-dependent and ALKBH5-mediated m6A-demethylation of NANOG mRNA. Proceedings of the National Academy of Sciences of the United States of America. PMID 27001847 DOI: 10.1073/pnas.1602883113  0.36
2016 Luo W, Chen I, Chen Y, Alkam D, Wang Y, Semenza GL. PRDX2 and PRDX4 are negative regulators of hypoxia-inducible factors under conditions of prolonged hypoxia. Oncotarget. PMID 26837221 DOI: 10.18632/oncotarget.7142  0.32
2016 Johns RA, Takimoto E, Meuchel LW, Elsaigh E, Zhang A, Heller NM, Semenza GL, Yamaji-Kegan K. Hypoxia-Inducible Factor 1α Is a Critical Downstream Mediator for Hypoxia-Induced Mitogenic Factor (FIZZ1/RELMα)-Induced Pulmonary Hypertension. Arteriosclerosis, Thrombosis, and Vascular Biology. 36: 134-44. PMID 26586659 DOI: 10.1161/ATVBAHA.115.306710  1
2016 Prabhakar NR, Semenza GL. Regulation of carotid body oxygen sensing by hypoxia-inducible factors. PflüGers Archiv : European Journal of Physiology. 468: 71-5. PMID 26265380 DOI: 10.1007/s00424-015-1719-z  1
2015 Zhang H, Lu H, Xiang L, Bullen JW, Zhang C, Samanta D, Gilkes DM, He J, Semenza GL. HIF-1 regulates CD47 expression in breast cancer cells to promote evasion of phagocytosis and maintenance of cancer stem cells. Proceedings of the National Academy of Sciences of the United States of America. PMID 26512116 DOI: 10.1073/pnas.1520032112  1
2015 Hubbi ME, Semenza GL. Regulation of cell proliferation by hypoxia-inducible factors. American Journal of Physiology. Cell Physiology. 309: C775-82. PMID 26491052 DOI: 10.1152/ajpcell.00279.2015  0.88
2015 Prabhakar NR, Semenza GL. Oxygen Sensing and Homeostasis. Physiology (Bethesda, Md.). 30: 340-8. PMID 26328879 DOI: 10.1152/physiol.00022.2015  1
2015 Ganten D, Semenza G, Sommer T. 151 years Berliner Klinische Wochenschrift and the 20th anniversary of the Journal of Molecular Medicine. Journal of Molecular Medicine (Berlin, Germany). 93: 935-6. PMID 26260526 DOI: 10.1007/s00109-015-1324-9  1
2015 Lu H, Samanta D, Xiang L, Zhang H, Hu H, Chen I, Bullen JW, Semenza GL. Chemotherapy triggers HIF-1-dependent glutathione synthesis and copper chelation that induces the breast cancer stem cell phenotype. Proceedings of the National Academy of Sciences of the United States of America. 112: E4600-9. PMID 26229077 DOI: 10.1073/pnas.1513433112  0.36
2015 Ma T, Patel H, Babapoor-Farrokhran S, Franklin R, Semenza GL, Sodhi A, Montaner S. KSHV induces aerobic glycolysis and angiogenesis through HIF-1-dependent upregulation of pyruvate kinase 2 in Kaposi's sarcoma. Angiogenesis. PMID 26092770 DOI: 10.1007/s10456-015-9475-4  1
2015 Xiang L, Gilkes DM, Hu H, Luo W, Bullen JW, Liang H, Semenza GL. HIF-1α and TAZ serve as reciprocal co-activators in human breast cancer cells. Oncotarget. 6: 11768-78. PMID 26059435  1
2015 Babapoor-Farrokhran S, Jee K, Puchner B, Hassan SJ, Xin X, Rodrigues M, Kashiwabuchi F, Ma T, Hu K, Deshpande M, Daoud Y, Solomon S, Wenick A, Lutty GA, Semenza GL, et al. Angiopoietin-like 4 is a potent angiogenic factor and a novel therapeutic target for patients with proliferative diabetic retinopathy. Proceedings of the National Academy of Sciences of the United States of America. 112: E3030-9. PMID 26039997 DOI: 10.1073/pnas.1423765112  1
2015 Semenza GL, Prabhakar NR. Neural regulation of hypoxia-inducible factors and redox state drives the pathogenesis of hypertension in a rodent model of sleep apnea. Journal of Applied Physiology (Bethesda, Md. : 1985). 119: 1152-6. PMID 25953833 DOI: 10.1152/japplphysiol.00162.2015  1
2015 Hubbi ME, Semenza GL. An essential role for chaperone-mediated autophagy in cell cycle progression. Autophagy. 11: 850-1. PMID 25945892 DOI: 10.1080/15548627.2015.1037063  0.88
2015 Yuan G, Vasavda C, Peng YJ, Makarenko VV, Raghuraman G, Nanduri J, Gadalla MM, Semenza GL, Kumar GK, Snyder SH, Prabhakar NR. Protein kinase G-regulated production of H2S governs oxygen sensing. Science Signaling. 8: ra37. PMID 25900831 DOI: 10.1126/scisignal.2005846  1
2015 Wang J, Fu X, Yang K, Jiang Q, Chen Y, Jia J, Duan X, Wang EW, He J, Ran P, Zhong N, Semenza GL, Lu W. Hypoxia inducible factor-1-dependent up-regulation of BMP4 mediates hypoxia-induced increase of TRPC expression in PASMCs. Cardiovascular Research. 107: 108-18. PMID 25824146 DOI: 10.1093/cvr/cvv122  1
2015 Nanduri J, Vaddi DR, Khan SA, Wang N, Makarenko V, Semenza GL, Prabhakar NR. HIF-1α activation by intermittent hypoxia requires NADPH oxidase stimulation by xanthine oxidase. Plos One. 10: e0119762. PMID 25751622 DOI: 10.1371/journal.pone.0119762  1
2014 Xiang L, Gilkes DM, Hu H, Takano N, Luo W, Lu H, Bullen JW, Samanta D, Liang H, Semenza GL. Hypoxia-inducible factor 1 mediates TAZ expression and nuclear localization to induce the breast cancer stem cell phenotype. Oncotarget. 5: 12509-27. PMID 25587023  1
2014 Samanta D, Gilkes DM, Chaturvedi P, Xiang L, Semenza GL. Hypoxia-inducible factors are required for chemotherapy resistance of breast cancer stem cells. Proceedings of the National Academy of Sciences of the United States of America. 111: E5429-38. PMID 25453096 DOI: 10.1073/pnas.1421438111  0.48
2014 Hu H, Takano N, Xiang L, Gilkes DM, Luo W, Semenza GL. Hypoxia-inducible factors enhance glutamate signaling in cancer cells. Oncotarget. 5: 8853-68. PMID 25326682  1
2014 Chapiro J, Sur S, Savic LJ, Ganapathy-Kanniappan S, Reyes J, Duran R, Thiruganasambandam SC, Moats CR, Lin M, Luo W, Tran PT, Herman JM, Semenza GL, Ewald AJ, Vogelstein B, et al. Systemic delivery of microencapsulated 3-bromopyruvate for the therapy of pancreatic cancer. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 20: 6406-17. PMID 25326230 DOI: 10.1158/1078-0432.CCR-14-1271  1
2014 Huang D, Li T, Li X, Zhang L, Sun L, He X, Zhong X, Jia D, Song L, Semenza GL, Gao P, Zhang H. HIF-1-mediated suppression of acyl-CoA dehydrogenases and fatty acid oxidation is critical for cancer progression. Cell Reports. 8: 1930-42. PMID 25242319 DOI: 10.1016/j.celrep.2014.08.028  0.36
2014 Lorenzo FR, Huff C, Myllymäki M, Olenchock B, Swierczek S, Tashi T, Gordeuk V, Wuren T, Ri-Li G, McClain DA, Khan TM, Koul PA, Guchhait P, Salama ME, Xing J, ... Semenza GL, et al. A genetic mechanism for Tibetan high-altitude adaptation. Nature Genetics. 46: 951-6. PMID 25129147 DOI: 10.1038/ng.3067  1
2014 Luo W, Lin B, Wang Y, Zhong J, O'Meally R, Cole RN, Pandey A, Levchenko A, Semenza GL. PHD3-mediated prolyl hydroxylation of nonmuscle actin impairs polymerization and cell motility. Molecular Biology of the Cell. 25: 2788-96. PMID 25079693 DOI: 10.1091/mbc.E14-02-0775  1
2014 Hubbi ME, Gilkes DM, Hu H, Kshitiz, Ahmed I, Semenza GL. Cyclin-dependent kinases regulate lysosomal degradation of hypoxia-inducible factor 1α to promote cell-cycle progression. Proceedings of the National Academy of Sciences of the United States of America. 111: E3325-34. PMID 25071185 DOI: 10.1073/pnas.1412840111  1
2014 Takano N, Sarfraz Y, Gilkes DM, Chaturvedi P, Xiang L, Suematsu M, Zagzag D, Semenza GL. Decreased expression of cystathionine β-synthase promotes glioma tumorigenesis. Molecular Cancer Research : McR. 12: 1398-406. PMID 24994751 DOI: 10.1158/1541-7786.MCR-14-0184  1
2014 Peng YJ, Yuan G, Khan S, Nanduri J, Makarenko VV, Reddy VD, Vasavda C, Kumar GK, Semenza GL, Prabhakar NR. Regulation of hypoxia-inducible factor-α isoforms and redox state by carotid body neural activity in rats. The Journal of Physiology. 592: 3841-58. PMID 24973414 DOI: 10.1113/jphysiol.2014.273789  1
2014 Wang T, Gilkes DM, Takano N, Xiang L, Luo W, Bishop CJ, Chaturvedi P, Green JJ, Semenza GL. Hypoxia-inducible factors and RAB22A mediate formation of microvesicles that stimulate breast cancer invasion and metastasis. Proceedings of the National Academy of Sciences of the United States of America. 111: E3234-42. PMID 24938788 DOI: 10.1073/pnas.1410041111  1
2014 Yang C, Jiang L, Zhang H, Shimoda LA, DeBerardinis RJ, Semenza GL. Analysis of hypoxia-induced metabolic reprogramming. Methods in Enzymology. 542: 425-55. PMID 24862279 DOI: 10.1016/B978-0-12-416618-9.00022-4  0.36
2014 Gilkes DM, Semenza GL, Wirtz D. Hypoxia and the extracellular matrix: drivers of tumour metastasis. Nature Reviews. Cancer. 14: 430-9. PMID 24827502 DOI: 10.1038/nrc3726  1
2014 Chaturvedi P, Gilkes DM, Takano N, Semenza GL. Hypoxia-inducible factor-dependent signaling between triple-negative breast cancer cells and mesenchymal stem cells promotes macrophage recruitment. Proceedings of the National Academy of Sciences of the United States of America. 111: E2120-9. PMID 24799675 DOI: 10.1073/pnas.1406655111  1
2014 Takano N, Peng YJ, Kumar GK, Luo W, Hu H, Shimoda LA, Suematsu M, Prabhakar NR, Semenza GL. Hypoxia-inducible factors regulate human and rat cystathionine β-synthase gene expression. The Biochemical Journal. 458: 203-11. PMID 24328859 DOI: 10.1042/BJ20131350  1
2014 Gilkes DM, Xiang L, Lee SJ, Chaturvedi P, Hubbi ME, Wirtz D, Semenza GL. Hypoxia-inducible factors mediate coordinated RhoA-ROCK1 expression and signaling in breast cancer cells. Proceedings of the National Academy of Sciences of the United States of America. 111: E384-93. PMID 24324133 DOI: 10.1073/pnas.1321510111  1
2014 Xiang L, Gilkes DM, Chaturvedi P, Luo W, Hu H, Takano N, Liang H, Semenza GL. Ganetespib blocks HIF-1 activity and inhibits tumor growth, vascularization, stem cell maintenance, invasion, and metastasis in orthotopic mouse models of triple-negative breast cancer. Journal of Molecular Medicine (Berlin, Germany). 92: 151-64. PMID 24248265 DOI: 10.1007/s00109-013-1102-5  1
2014 Jiang X, Malkovskiy AV, Tian W, Sung YK, Sun W, Hsu JL, Manickam S, Wagh D, Joubert LM, Semenza GL, Rajadas J, Nicolls MR. Promotion of airway anastomotic microvascular regeneration and alleviation of airway ischemia by deferoxamine nanoparticles. Biomaterials. 35: 803-13. PMID 24161166 DOI: 10.1016/j.biomaterials.2013.09.092  1
2013 Gilkes DM, Semenza GL. Role of hypoxia-inducible factors in breast cancer metastasis. Future Oncology (London, England). 9: 1623-36. PMID 24156323 DOI: 10.2217/fon.13.92  1
2013 Cai Z, Luo W, Zhan H, Semenza GL. Hypoxia-inducible factor 1 is required for remote ischemic preconditioning of the heart. Proceedings of the National Academy of Sciences of the United States of America. 110: 17462-7. PMID 24101519 DOI: 10.1073/pnas.1317158110  0.32
2013 Chen Z, Barbi J, Bu S, Yang HY, Li Z, Gao Y, Jinasena D, Fu J, Lin F, Chen C, Zhang J, Yu N, Li X, Shan Z, Nie J, ... ... Semenza GL, et al. The ubiquitin ligase Stub1 negatively modulates regulatory T cell suppressive activity by promoting degradation of the transcription factor Foxp3. Immunity. 39: 272-85. PMID 23973223 DOI: 10.1016/j.immuni.2013.08.006  0.32
2013 Xin X, Rodrigues M, Umapathi M, Kashiwabuchi F, Ma T, Babapoor-Farrokhran S, Wang S, Hu J, Bhutto I, Welsbie DS, Duh EJ, Handa JT, Eberhart CG, Lutty G, Semenza GL, et al. Hypoxic retinal Muller cells promote vascular permeability by HIF-1-dependent up-regulation of angiopoietin-like 4. Proceedings of the National Academy of Sciences of the United States of America. 110: E3425-34. PMID 23959876 DOI: 10.1073/pnas.1217091110  1
2013 Rodrigues M, Xin X, Jee K, Babapoor-Farrokhran S, Kashiwabuchi F, Ma T, Bhutto I, Hassan SJ, Daoud Y, Baranano D, Solomon S, Lutty G, Semenza GL, Montaner S, Sodhi A. VEGF secreted by hypoxic Müller cells induces MMP-2 expression and activity in endothelial cells to promote retinal neovascularization in proliferative diabetic retinopathy. Diabetes. 62: 3863-73. PMID 23884892 DOI: 10.2337/db13-0014  1
2013 Jiang X, Hsu JL, Tian W, Yuan K, Olcholski M, Perez Vde J, Semenza GL, Nicolls MR. Tie2-dependent VHL knockdown promotes airway microvascular regeneration and attenuates invasive growth of Aspergillus fumigatus. Journal of Molecular Medicine (Berlin, Germany). 91: 1081-93. PMID 23797537 DOI: 10.1007/s00109-013-1063-8  1
2013 Hubbi ME, Hu H, Kshitiz, Gilkes DM, Semenza GL. Sirtuin-7 inhibits the activity of hypoxia-inducible factors. The Journal of Biological Chemistry. 288: 20768-75. PMID 23750001 DOI: 10.1074/jbc.M113.476903  1
2013 Agus DB, Alexander JF, Arap W, Ashili S, Aslan JE, Austin RH, Backman V, Bethel KJ, Bonneau R, Chen WC, Chen-Tanyolac C, Choi NC, Curley SA, Dallas M, ... ... Semenza GL, et al. A physical sciences network characterization of non-tumorigenic and metastatic cells. Scientific Reports. 3: 1449. PMID 23618955 DOI: 10.1038/srep01449  1
2013 Yuan G, Peng YJ, Reddy VD, Makarenko VV, Nanduri J, Khan SA, Garcia JA, Kumar GK, Semenza GL, Prabhakar NR. Mutual antagonism between hypoxia-inducible factors 1α and 2α regulates oxygen sensing and cardio-respiratory homeostasis. Proceedings of the National Academy of Sciences of the United States of America. 110: E1788-96. PMID 23610397 DOI: 10.1073/pnas.1305961110  1
2013 Gilkes DM, Chaturvedi P, Bajpai S, Wong CC, Wei H, Pitcairn S, Hubbi ME, Wirtz D, Semenza GL. Collagen prolyl hydroxylases are essential for breast cancer metastasis. Cancer Research. 73: 3285-96. PMID 23539444 DOI: 10.1158/0008-5472.CAN-12-3963  1
2013 Hubbi ME, Hu H, Kshitiz, Ahmed I, Levchenko A, Semenza GL. Chaperone-mediated autophagy targets hypoxia-inducible factor-1α (HIF-1α) for lysosomal degradation. The Journal of Biological Chemistry. 288: 10703-14. PMID 23457305 DOI: 10.1074/jbc.M112.414771  0.88
2013 Gilkes DM, Bajpai S, Chaturvedi P, Wirtz D, Semenza GL. Hypoxia-inducible factor 1 (HIF-1) promotes extracellular matrix remodeling under hypoxic conditions by inducing P4HA1, P4HA2, and PLOD2 expression in fibroblasts. The Journal of Biological Chemistry. 288: 10819-29. PMID 23423382 DOI: 10.1074/jbc.M112.442939  1
2013 Pisarcik S, Maylor J, Lu W, Yun X, Undem C, Sylvester JT, Semenza GL, Shimoda LA. Activation of hypoxia-inducible factor-1 in pulmonary arterial smooth muscle cells by endothelin-1. American Journal of Physiology. Lung Cellular and Molecular Physiology. 304: L549-61. PMID 23418090 DOI: 10.1152/ajplung.00081.2012  0.32
2013 Hubbi ME, Kshitiz, Gilkes DM, Rey S, Wong CC, Luo W, Kim DH, Dang CV, Levchenko A, Semenza GL. A nontranscriptional role for HIF-1α as a direct inhibitor of DNA replication Science Signaling. 6. PMID 23405012 DOI: 10.1126/scisignal.2003417  1
2013 Gilkes DM, Bajpai S, Wong CC, Chaturvedi P, Hubbi ME, Wirtz D, Semenza GL. Procollagen lysyl hydroxylase 2 is essential for hypoxia-induced breast cancer metastasis. Molecular Cancer Research : McR. 11: 456-66. PMID 23378577 DOI: 10.1158/1541-7786.MCR-12-0629  1
2013 Drager LF, Yao Q, Hernandez KL, Shin MK, Bevans-Fonti S, Gay J, Sussan TE, Jun JC, Myers AC, Olivecrona G, Schwartz AR, Halberg N, Scherer PE, Semenza GL, Powell DR, et al. Chronic intermittent hypoxia induces atherosclerosis via activation of adipose angiopoietin-like 4. American Journal of Respiratory and Critical Care Medicine. 188: 240-8. PMID 23328524 DOI: 10.1164/rccm.201209-1688OC  1
2013 Chaturvedi P, Gilkes DM, Wong CC, Luo W, Zhang H, Wei H, Takano N, Schito L, Levchenko A, Semenza GL. Hypoxia-inducible factor-dependent breast cancer-mesenchymal stem cell bidirectional signaling promotes metastasis. The Journal of Clinical Investigation. 123: 189-205. PMID 23318994 DOI: 10.1172/JCI64993  1
2012 Luo W, Chang R, Zhong J, Pandey A, Semenza GL. Histone demethylase JMJD2C is a coactivator for hypoxia-inducible factor 1 that is required for breast cancer progression. Proceedings of the National Academy of Sciences of the United States of America. 109: E3367-76. PMID 23129632 DOI: 10.1073/pnas.1217394109  0.32
2012 Semenza GL, Prabhakar NR. The role of hypoxia-inducible factors in oxygen sensing by the carotid body. Advances in Experimental Medicine and Biology. 758: 1-5. PMID 23080136 DOI: 10.1007/978-94-007-4584-1_1  1
2012 Schito L, Rey S, Tafani M, Zhang H, Wong CCL, Russo A, Russo MA, Semenza GL. Hypoxia-inducible factor 1-dependent expression of platelet-derived growth factor B promotes lymphatic metastasis of hypoxic breast cancer cells Proceedings of the National Academy of Sciences of the United States of America. 109: E2707-E2716. PMID 23012449 DOI: 10.1073/pnas.1214019109  1
2012 Krishnamachary B, Penet MF, Nimmagadda S, Mironchik Y, Raman V, Solaiyappan M, Semenza GL, Pomper MG, Bhujwalla ZM. Hypoxia regulates CD44 and its variant isoforms through HIF-1α in triple negative breast cancer. Plos One. 7: e44078. PMID 22937154 DOI: 10.1371/journal.pone.0044078  1
2012 Luo W, Semenza GL. Emerging roles of PKM2 in cell metabolism and cancer progression. Trends in Endocrinology and Metabolism: Tem. 23: 560-6. PMID 22824010 DOI: 10.1016/j.tem.2012.06.010  0.32
2012 Prabhakar NR, Semenza GL. Adaptive and maladaptive cardiorespiratory responses to continuous and intermittent hypoxia mediated by hypoxia-inducible factors 1 and 2. Physiological Reviews. 92: 967-1003. PMID 22811423 DOI: 10.1152/physrev.00030.2011  1
2012 Kshitiz, Hubbi ME, Ahn EH, Downey J, Afzal J, Kim DH, Rey S, Chang C, Kundu A, Semenza GL, Abraham RM, Levchenko A. Matrix rigidity controls endothelial differentiation and morphogenesis of cardiac precursors. Science Signaling. 5: ra41. PMID 22669846 DOI: 10.1126/scisignal.2003002  1
2012 Wei H, Bedja D, Koitabashi N, Xing D, Chen J, Fox-Talbot K, Rouf R, Chen S, Steenbergen C, Harmon JW, Dietz HC, Gabrielson KL, Kass DA, Semenza GL. Endothelial expression of hypoxia-inducible factor 1 protects the murine heart and aorta from pressure overload by suppression of TGF-β signaling. Proceedings of the National Academy of Sciences of the United States of America. 109: E841-50. PMID 22403061 DOI: 10.1073/pnas.1202081109  1
2012 Semenza GL, Prabhakar NR. Gas biology: small molecular medicine. Journal of Molecular Medicine (Berlin, Germany). 90: 213-5. PMID 22349395 DOI: 10.1007/s00109-012-0877-0  1
2012 Prabhakar NR, Semenza GL. Gaseous messengers in oxygen sensing. Journal of Molecular Medicine (Berlin, Germany). 90: 265-72. PMID 22349394 DOI: 10.1007/s00109-012-0876-1  1
2012 Abud EM, Maylor J, Undem C, Punjabi A, Zaiman AL, Myers AC, Sylvester JT, Semenza GL, Shimoda LA. Digoxin inhibits development of hypoxic pulmonary hypertension in mice. Proceedings of the National Academy of Sciences of the United States of America. 109: 1239-44. PMID 22232678 DOI: 10.1073/pnas.1120385109  1
2012 Nanduri J, Makarenko V, Reddy VD, Yuan G, Pawar A, Wang N, Khan SA, Zhang X, Kinsman B, Peng YJ, Kumar GK, Fox AP, Godley LA, Semenza GL, Prabhakar NR. Epigenetic regulation of hypoxic sensing disrupts cardiorespiratory homeostasis. Proceedings of the National Academy of Sciences of the United States of America. 109: 2515-20. PMID 22232674 DOI: 10.1073/pnas.1120600109  1
2012 Wong CC, Zhang H, Gilkes DM, Chen J, Wei H, Chaturvedi P, Hubbi ME, Semenza GL. Inhibitors of hypoxia-inducible factor 1 block breast cancer metastatic niche formation and lung metastasis. Journal of Molecular Medicine (Berlin, Germany). 90: 803-15. PMID 22231744 DOI: 10.1007/s00109-011-0855-y  1
2012 Hubbi ME, Gilkes DM, Baek JH, Semenza GL. Four-and-a-half LIM domain proteins inhibit transactivation by hypoxia-inducible factor 1. The Journal of Biological Chemistry. 287: 6139-49. PMID 22219185 DOI: 10.1074/jbc.M111.278630  1
2012 Sarkar K, Rey S, Zhang X, Sebastian R, Marti GP, Fox-Talbot K, Cardona AV, Du J, Tan YS, Liu L, Lay F, Gonzalez FJ, Harmon JW, Semenza GL. Tie2-dependent knockout of HIF-1 impairs burn wound vascularization and homing of bone marrow-derived angiogenic cells. Cardiovascular Research. 93: 162-9. PMID 22028336 DOI: 10.1093/cvr/cvr282  1
2011 Wong CC, Gilkes DM, Zhang H, Chen J, Wei H, Chaturvedi P, Fraley SI, Wong CM, Khoo US, Ng IO, Wirtz D, Semenza GL. Hypoxia-inducible factor 1 is a master regulator of breast cancer metastatic niche formation. Proceedings of the National Academy of Sciences of the United States of America. 108: 16369-74. PMID 21911388 DOI: 10.1073/pnas.1113483108  1
2011 Dang EV, Barbi J, Yang HY, Jinasena D, Yu H, Zheng Y, Bordman Z, Fu J, Kim Y, Yen HR, Luo W, Zeller K, Shimoda L, Topalian SL, Semenza GL, et al. Control of TH17/Treg balance by hypoxia-inducible factor 1 Cell. 146: 772-784. PMID 21871655 DOI: 10.1016/j.cell.2011.07.033  1
2011 Luo W, Semenza GL. Pyruvate kinase M2 regulates glucose metabolism by functioning as a coactivator for hypoxia-inducible factor 1 in cancer cells. Oncotarget. 2: 551-6. PMID 21709315 DOI: 10.18632/oncotarget.299  0.32
2011 Hubbi ME, Luo W, Baek JH, Semenza GL. MCM proteins are negative regulators of hypoxia-inducible factor 1. Molecular Cell. 42: 700-12. PMID 21658608 DOI: 10.1016/j.molcel.2011.03.029  0.88
2011 Luo W, Hu H, Chang R, Zhong J, Knabel M, O'Meally R, Cole RN, Pandey A, Semenza GL. Pyruvate kinase M2 is a PHD3-stimulated coactivator for hypoxia-inducible factor 1. Cell. 145: 732-44. PMID 21620138 DOI: 10.1016/j.cell.2011.03.054  0.36
2011 Jiang X, Khan MA, Tian W, Beilke J, Natarajan R, Kosek J, Yoder MC, Semenza GL, Nicolls MR. Adenovirus-mediated HIF-1α gene transfer promotes repair of mouse airway allograft microvasculature and attenuates chronic rejection. The Journal of Clinical Investigation. 121: 2336-49. PMID 21606594 DOI: 10.1172/JCI46192  1
2011 Zhang X, Sarkar K, Rey S, Sebastian R, Andrikopoulou E, Marti GP, Fox-Talbot K, Semenza GL, Harmon JW. Aging impairs the mobilization and homing of bone marrow-derived angiogenic cells to burn wounds. Journal of Molecular Medicine (Berlin, Germany). 89: 985-95. PMID 21499736 DOI: 10.1007/s00109-011-0754-2  1
2011 Rey S, Luo W, Shimoda LA, Semenza GL. Metabolic reprogramming by HIF-1 promotes the survival of bone marrow-derived angiogenic cells in ischemic tissue Blood. 117: 4988-4998. PMID 21389314 DOI: 10.1182/blood-2010-11-321190  1
2011 Yuan G, Khan SA, Luo W, Nanduri J, Semenza GL, Prabhakar NR. Hypoxia-inducible factor 1 mediates increased expression of NADPH oxidase-2 in response to intermittent hypoxia. Journal of Cellular Physiology. 226: 2925-33. PMID 21302291 DOI: 10.1002/jcp.22640  1
2011 Peng YJ, Nanduri J, Khan SA, Yuan G, Wang N, Kinsman B, Vaddi DR, Kumar GK, Garcia JA, Semenza GL, Prabhakar NR. Hypoxia-inducible factor 2α (HIF-2α) heterozygous-null mice exhibit exaggerated carotid body sensitivity to hypoxia, breathing instability, and hypertension. Proceedings of the National Academy of Sciences of the United States of America. 108: 3065-70. PMID 21288809 DOI: 10.1073/pnas.1100064108  1
2011 Shimoda LA, Semenza GL. HIF and the lung: role of hypoxia-inducible factors in pulmonary development and disease. American Journal of Respiratory and Critical Care Medicine. 183: 152-6. PMID 21242594 DOI: 10.1164/rccm.201009-1393PP  0.32
2011 Kannan KB, Colorado I, Reino D, Palange D, Lu Q, Qin X, Abungu B, Watkins A, Caputo FJ, Xu DZ, Semenza GL, Deitch EA, Feinman R. Hypoxia-inducible factor plays a gut-injurious role in intestinal ischemia reperfusion injury. American Journal of Physiology. Gastrointestinal and Liver Physiology. 300: G853-61. PMID 21183660 DOI: 10.1152/ajpgi.00459.2010  1
2010 Guan Y, Ramasamy Reddy K, Zhu Q, Li Y, Lee K, Weerasinghe P, Prchal J, Semenza GL, Jing N. G-rich Oligonucleotides Inhibit HIF-1α and HIF-2α and Block Tumor Growth. Molecular Therapy : the Journal of the American Society of Gene Therapy. 18: 188-197. PMID 28178550 DOI: 10.1038/mt.2009.219  0.36
2010 Feinman R, Deitch EA, Watkins AC, Abungu B, Colorado I, Kannan KB, Sheth SU, Caputo FJ, Lu Q, Ramanathan M, Attan S, Badami CD, Doucet D, Barlos D, Bosch-Marce M, ... Semenza GL, et al. HIF-1 mediates pathogenic inflammatory responses to intestinal ischemia-reperfusion injury. American Journal of Physiology. Gastrointestinal and Liver Physiology. 299: G833-43. PMID 20689059 DOI: 10.1152/ajpgi.00065.2010  1
2010 Rey S, Semenza GL. Hypoxia-inducible factor-1-dependent mechanisms of vascularization and vascular remodelling Cardiovascular Research. 86: 236-242. PMID 20164116 DOI: 10.1093/cvr/cvq045  1
2009 Rey S, Lee K, Wang CJ, Gupta K, Chen S, McMillan A, Bhise N, Levchenko A, Semenza GL. Synergistic effect of HIF-1alpha gene therapy and HIF-1-activated bone marrow-derived angiogenic cells in a mouse model of limb ischemia. Proceedings of the National Academy of Sciences of the United States of America. 106: 20399-404. PMID 19948968 DOI: 10.1073/pnas.0911921106  1
2009 Lee K, Zhang H, Qian DZ, Rey S, Liu JO, Semenza GL. Acriflavine inhibits HIF-1 dimerization, tumor growth, and vascularization. Proceedings of the National Academy of Sciences of the United States of America. 106: 17910-5. PMID 19805192 DOI: 10.1073/pnas.0909353106  1
2009 Lee K, Qian DZ, Rey S, Wei H, Liu JO, Semenza GL. Anthracycline chemotherapy inhibits HIF-1 transcriptional activity and tumor-induced mobilization of circulating angiogenic cells. Proceedings of the National Academy of Sciences of the United States of America. 106: 2353-8. PMID 19168635 DOI: 10.1073/pnas.0812801106  1
2008 Zhang H, Qian DZ, Tan YS, Lee K, Gao P, Ren YR, Rey S, Hammers H, Chang D, Pili R, Dang CV, Liu JO, Semenza GL. Digoxin and other cardiac glycosides inhibit HIF-1α synthesis and block tumor growth Proceedings of the National Academy of Sciences of the United States of America. 105: 19579-19586. PMID 19020076 DOI: 10.1073/pnas.0809763105  1
2008 Zhang H, Bosch-Marce M, Shimoda LA, Tan YS, Baek JH, Wesley JB, Gonzalez FJ, Semenza GL. Mitochondrial autophagy is an HIF-1-dependent adaptive metabolic response to hypoxia. The Journal of Biological Chemistry. 283: 10892-903. PMID 18281291 DOI: 10.1074/jbc.M800102200  1
2008 Cai Z, Zhong H, Bosch-Marce M, Fox-Talbot K, Wang L, Wei C, Trush MA, Semenza GL. Complete loss of ischaemic preconditioning-induced cardioprotection in mice with partial deficiency of HIF-1 alpha. Cardiovascular Research. 77: 463-70. PMID 18006459 DOI: 10.1093/cvr/cvm035  0.32
2007 Liu YV, Hubbi ME, Pan F, McDonald KR, Mansharamani M, Cole RN, Liu JO, Semenza GL. Calcineurin promotes hypoxia-inducible factor 1alpha expression by dephosphorylating RACK1 and blocking RACK1 dimerization. The Journal of Biological Chemistry. 282: 37064-73. PMID 17965024 DOI: 10.1074/jbc.M705015200  1
2007 Bosch-Marce M, Okuyama H, Wesley JB, Sarkar K, Kimura H, Liu YV, Zhang H, Strazza M, Rey S, Savino L, Zhou YF, McDonald KR, Na Y, Vandiver S, Rabi A, ... ... Semenza GL, et al. Effects of aging and hypoxia-inducible factor-1 activity on angiogenic cell mobilization and recovery of perfusion after limb ischemia. Circulation Research. 101: 1310-8. PMID 17932327 DOI: 10.1161/CIRCRESAHA.107.153346  1
2007 Baek JH, Liu YV, McDonald KR, Wesley JB, Hubbi ME, Byun H, Semenza GL. Spermidine/spermine-N1-acetyltransferase 2 is an essential component of the ubiquitin ligase complex that regulates hypoxia-inducible factor 1alpha. The Journal of Biological Chemistry. 282: 23572-80. PMID 17558023 DOI: 10.1074/jbc.M703504200  1
2007 Komatsu DE, Bosch-Marce M, Semenza GL, Hadjiargyrou M. Enhanced bone regeneration associated with decreased apoptosis in mice with partial HIF-1alpha deficiency. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. 22: 366-74. PMID 17181398 DOI: 10.1359/jbmr.061207  1
2006 Zhou YF, Bosch-Marce M, Okuyama H, Krishnamachary B, Kimura H, Zhang L, Huso DL, Semenza GL. Spontaneous transformation of cultured mouse bone marrow-derived stromal cells. Cancer Research. 66: 10849-54. PMID 17108121 DOI: 10.1158/0008-5472.CAN-06-2146  0.44
2006 Peng YJ, Yuan G, Ramakrishnan D, Sharma SD, Bosch-Marce M, Kumar GK, Semenza GL, Prabhakar NR. Heterozygous HIF-1alpha deficiency impairs carotid body-mediated systemic responses and reactive oxygen species generation in mice exposed to intermittent hypoxia. The Journal of Physiology. 577: 705-16. PMID 16973705 DOI: 10.1113/jphysiol.2006.114033  1
2006 Okuyama H, Krishnamachary B, Zhou YF, Nagasawa H, Bosch-Marce M, Semenza GL. Expression of vascular endothelial growth factor receptor 1 in bone marrow-derived mesenchymal cells is dependent on hypoxia-inducible factor 1. The Journal of Biological Chemistry. 281: 15554-63. PMID 16574650 DOI: 10.1074/jbc.M602003200  0.44
2006 Li J, Bosch-Marce M, Nanayakkara A, Savransky V, Fried SK, Semenza GL, Polotsky VY. Altered metabolic responses to intermittent hypoxia in mice with partial deficiency of hypoxia-inducible factor-1alpha. Physiological Genomics. 25: 450-7. PMID 16507783 DOI: 10.1152/physiolgenomics.00293.2005  0.32
1998 Yu AY, Frid MG, Shimoda LA, Wiener CM, Stenmark K, Semenza GL. Temporal, spatial, and oxygen-regulated expression of hypoxia-inducible factor-1 in the lung. American Journal of Physiology. Lung Cellular and Molecular Physiology. 275: L818-L826. PMID 29585640 DOI: 10.1152/ajplung.1998.275.4.L818  0.32
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