Gregg L. Semenza - Publications

Affiliations: 
Johns Hopkins University, Baltimore, MD 
Area:
Cell Biology, Molecular Biology
Website:
https://www.hopkinsmedicine.org/profiles/results/directory/profile/0800056/gregg-semenza

314 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Wang Y, Lyu Y, Tu K, Xu Q, Yang Y, Salman S, Le N, Lu H, Chen C, Zhu Y, Wang R, Liu Q, Semenza GL. Histone citrullination by PADI4 is required for HIF-dependent transcriptional responses to hypoxia and tumor vascularization. Science Advances. 7. PMID 34452909 DOI: 10.1126/sciadv.abe3771  1
2021 Zhang J, Qin Y, Martinez M, Flores-Bellver M, Rodrigues M, Dinabandhu A, Cao X, Deshpande M, Qin Y, Aparicio-Domingo S, Rui Y, Tzeng SY, Salman S, Yuan J, Scott AW, ... ... Semenza GL, et al. HIF-1α and HIF-2α redundantly promote retinal neovascularization in patients with ischemic retinal disease. The Journal of Clinical Investigation. 131. PMID 34128478 DOI: 10.1172/JCI139202  1
2021 Semenza GL. Heritable disorders of oxygen sensing. American Journal of Medical Genetics. Part A. PMID 33973706 DOI: 10.1002/ajmg.a.62250  0.01
2021 Wang R, Godet I, Yang Y, Salman S, Lu H, Lyu Y, Zuo Q, Wang Y, Zhu Y, Chen C, He J, Gilkes DM, Semenza GL. Hypoxia-inducible factor-dependent ADAM12 expression mediates breast cancer invasion and metastasis. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 33952697 DOI: 10.1073/pnas.2020490118  1
2021 Hu K, Babapoor-Farrokhran S, Rodrigues M, Deshpande M, Puchner B, Kashiwabuchi F, Hassan SJ, Asnaghi L, Handa JT, Merbs S, Eberhart CG, Semenza GL, Montaner S, Sodhi A. Correction: Hypoxia-inducible factor 1 upregulation of both VEGF and ANGPTL4 is required to promote the angiogenic phenotype in uveal melanoma. Oncotarget. 12: 519-520. PMID 33747364 DOI: 10.18632/oncotarget.27780  1
2021 Semenza GL. Intratumoral Hypoxia and Mechanisms of Immune Evasion Mediated by Hypoxia-Inducible Factors. Physiology (Bethesda, Md.). 36: 73-83. PMID 33595388 DOI: 10.1152/physiol.00034.2020  0.01
2021 Lu H, Chen I, Shimoda LA, Park Y, Zhang C, Tran L, Zhang H, Semenza GL. Chemotherapy-Induced Ca Release Stimulates Breast Cancer Stem Cell Enrichment. Cell Reports. 34: 108605. PMID 33406433 DOI: 10.1016/j.celrep.2020.108605  1
2021 Liu Z, Sun L, Cai Y, Shen S, Zhang T, Wang N, Wu G, Ma W, Li ST, Suo C, Hao Y, Jia WD, Semenza GL, Gao P, Zhang H. Hypoxia-induced suppression of alternative splicing of MBD2 promotes breast cancer metastasis via activation of FZD1. Cancer Research. PMID 33402389 DOI: 10.1158/0008-5472.CAN-20-2876  1
2020 Wang N, Shi XF, Khan SA, Wang B, Semenza GL, Prabhakar NR, Nanduri J. Hypoxia inducible factor-1 mediates pancreatic β-cell dysfunction by intermittent hypoxia. American Journal of Physiology. Cell Physiology. PMID 32936698 DOI: 10.1152/Ajpcell.00309.2020  1
2020 Samanta D, Huang TY, Shah R, Yang Y, Pan F, Semenza GL. BIRC2 Expression Impairs Anti-Cancer Immunity and Immunotherapy Efficacy. Cell Reports. 32: 108073. PMID 32846130 DOI: 10.1016/J.Celrep.2020.108073  1
2020 Jiang X, Tian W, Granucci EJ, Tu AB, Kim D, Dahms P, Pasupneti S, Peng G, Kim Y, Lim AH, Espinoza FH, Cribb M, Dixon JB, Rockson SG, Semenza GL, et al. Decreased lymphatic HIF-2α accentuates lymphatic remodeling in lymphedema. The Journal of Clinical Investigation. PMID 32673288 DOI: 10.1172/Jci136164  1
2020 Pasupneti S, Tian W, Tu AB, Dahms P, Granucci E, Gandjeva A, Xiang M, Butcher E, Semenza GL, Tuder R, Jiang X, Nicolls MR. Endothelial HIF-2α as a Key Endogenous Mediator Preventing Emphysema. American Journal of Respiratory and Critical Care Medicine. PMID 32515984 DOI: 10.1164/Rccm.202001-0078Oc  1
2020 Lu H, Xie Y, Tran L, Lan J, Yang Y, Murugan NL, Wang R, Wang YJ, Semenza GL. Chemotherapy-induced S100A10 recruits KDM6A to facilitate OCT4-mediated breast cancer stemness. The Journal of Clinical Investigation. PMID 32427586 DOI: 10.1172/Jci138577  1
2020 Semenza GL. The Genomics and Genetics of Oxygen Homeostasis. Annual Review of Genomics and Human Genetics. PMID 32255719 DOI: 10.1146/Annurev-Genom-111119-073356  0.01
2020 Ahima RS, Jackson S, Casadevall A, Semenza GL, Tomaselli G, Collins KL, Lieberman AP, Martin DM, Reddy P. Changing the editorial process at JCI and JCI Insight in response to the COVID-19 pandemic. The Journal of Clinical Investigation. PMID 32202513 DOI: 10.1172/Jci138305  0.01
2019 Bohuslavova R, Cerychova R, Papousek F, Olejnickova V, Bartos M, Görlach A, Kolar F, Sedmera D, Semenza GL, Pavlinkova G. HIF-1α is required for development of the sympathetic nervous system. Proceedings of the National Academy of Sciences of the United States of America. PMID 31196952 DOI: 10.1073/Pnas.1903510116  0.01
2019 Dabral S, Muecke C, Valasarajan C, Schmoranzer M, Wietelmann A, Semenza GL, Meister M, Muley T, Seeger-Nukpezah T, Samakovlis C, Weissmann N, Grimminger F, Seeger W, Savai R, Pullamsetti SS. A RASSF1A-HIF1α loop drives Warburg effect in cancer and pulmonary hypertension. Nature Communications. 10: 2130. PMID 31086178 DOI: 10.1038/S41467-019-10044-Z  0.01
2019 Casadevall A, Semenza GL, Jackson S, Tomaselli G, Ahima RS. Reducing bias: accounting for the order of co-first authors. The Journal of Clinical Investigation. 130. PMID 31033485 DOI: 10.1172/Jci128764  0.01
2019 Xiang L, Semenza GL. Hypoxia-inducible factors promote breast cancer stem cell specification and maintenance in response to hypoxia or cytotoxic chemotherapy. Advances in Cancer Research. 141: 175-212. PMID 30691683 DOI: 10.1016/Bs.Acr.2018.11.001  1
2019 Xiang L, Mou J, Shao B, Wei Y, Liang H, Takano N, Semenza GL, Xie G. Glutaminase 1 expression in colorectal cancer cells is induced by hypoxia and required for tumor growth, invasion, and metastatic colonization. Cell Death & Disease. 10: 40. PMID 30674873 DOI: 10.1038/S41419-018-1291-5  1
2019 Semenza GL. Pharmacologic Targeting of Hypoxia-Inducible Factors. Annual Review of Pharmacology and Toxicology. 59: 379-403. PMID 30625281 DOI: 10.1146/Annurev-Pharmtox-010818-021637  0.01
2018 Jiang X, Tian W, Tu AB, Pasupneti S, Shuffle E, Dahms P, Zhang P, Cai H, Dinh TT, Liu B, Cain C, Giaccia AJ, Butcher EC, Simon C, Semenza GL, et al. Endothelial HIF-2α is Required for the Maintenance of Airway Microvasculature. Circulation. PMID 30586708 DOI: 10.1161/Circulationaha.118.036157  1
2018 Lan J, Lu H, Samanta D, Salman S, Lu Y, Semenza GL. Hypoxia-inducible factor 1-dependent expression of adenosine receptor 2B promotes breast cancer stem cell enrichment. Proceedings of the National Academy of Sciences of the United States of America. PMID 30242135 DOI: 10.1073/Pnas.1809695115  1
2018 Samanta D, Semenza GL. Metabolic adaptation of cancer and immune cells mediated by hypoxia-inducible factors. Biochimica Et Biophysica Acta. PMID 30006019 DOI: 10.1016/J.Bbcan.2018.07.002  1
2018 Lu H, Tran L, Park Y, Chen I, Lan J, Xie Y, Semenza GL. Reciprocally Regulation of DUSP9 and DUSP16 Expression by HIF-1 Controls ERK and p38 MAP Kinase Activity and Mediates Chemotherapy-Induced Breast Cancer Stem Cell Enrichment. Cancer Research. PMID 29880481 DOI: 10.1158/0008-5472.Can-18-0270  1
2018 Bao L, Chen Y, Lai HT, Wu SY, Wang JE, Hatanpaa KJ, Raisanen JM, Fontenot M, Lega B, Chiang CM, Semenza GL, Wang Y, Luo W. Methylation of hypoxia-inducible factor (HIF)-1α by G9a/GLP inhibits HIF-1 transcriptional activity and cell migration. Nucleic Acids Research. PMID 29860315 DOI: 10.1093/Nar/Gky449  1
2018 Li J, Yang Q, Bai Z, Semenza GL, Ge RL. Chronic cold exposure results in subcutaneous adipose tissue browning and altered global metabolism in Qinghai-Tibetan plateau pika (Ochotona curzoniae). Biochemical and Biophysical Research Communications. PMID 29626477 DOI: 10.1016/J.Bbrc.2018.03.147  0.01
2018 Samanta D, Park Y, Ni X, Li H, Zahnow CA, Gabrielson E, Pan F, Semenza GL. Chemotherapy induces enrichment of CD47+/CD73+/PDL1+ immune evasive triple-negative breast cancer cells. Proceedings of the National Academy of Sciences of the United States of America. PMID 29367423 DOI: 10.1073/Pnas.1718197115  1
2018 Semenza GL, Prabhakar NR. The role of hypoxia-inducible factors in carotid body (patho) physiology. The Journal of Physiology. PMID 29359806 DOI: 10.1113/Jp275696  1
2018 Samanta D, Semenza GL. In Vitro Assays of Breast Cancer Stem Cells. Methods in Molecular Biology (Clifton, N.J.). 1742: 237-246. PMID 29330805 DOI: 10.1007/978-1-4939-7665-2_21  1
2018 Bao L, Chen Y, Lai H, Chiang C, Semenza GL, Wang Y, Luo W. Abstract 5427: Inhibition of hypoxia-inducible factor 1 (HIF-1) transcriptional activity and cell mobility via G9a/GLP-mediated methylation of HIF-1α Cancer Research. 78: 5427-5427. DOI: 10.1158/1538-7445.Am2018-5427  1
2017 Fu C, Tyagi R, Chin AC, Rojas T, Li RJ, Guha P, Bernstein IA, Rao F, Xu R, Cha JY, Xu J, Snowman AM, Semenza GL, Snyder SH. Inositol Polyphosphate Multikinase Inhibits Angiogenesis via Inositol Pentakisphosphate-Induced HIF-1α Degradation. Circulation Research. PMID 29279301 DOI: 10.1161/Circresaha.117.311983  1
2017 Nanduri J, Peng YJ, Wang N, Khan SA, Semenza GL, Prabhakar NR. DNA methylation in the central and efferent limbs of the chemo reflex requires carotid body neural activity. The Journal of Physiology. PMID 29148180 DOI: 10.1113/Jp274833  1
2017 Applewhite BP, Babapoor-Farrokhran S, Poon D, Hassan SJ, Wellmann E, Ying HS, Semenza GL, Montaner S, Sodhi A. Lack of Evidence for Vasoactive and Inflammatory Mediators in the Promotion of Macular Edema Associated with Epiretinal Membranes. Scientific Reports. 7: 10608. PMID 28878218 DOI: 10.1038/S41598-017-08997-6  1
2017 Meng Q, Qin Y, Deshpande M, Kashiwabuchi F, Rodrigues M, Lu Q, Ren H, Elisseeff JH, Semenza GL, Montaner SV, Sodhi A. Hypoxia-Inducible Factor-Dependent Expression of Angiopoietin-Like 4 by Conjunctival Epithelial Cells Promotes the Angiogenic Phenotype of Pterygia. Investigative Ophthalmology & Visual Science. 58: 4514-4523. PMID 28873177 DOI: 10.1167/Iovs.17-21974  1
2017 Nanduri J, Semenza GL, Prabhakar NR. Epigenetic Changes by DNA methylation in Chronic and Intermittent Hypoxia. American Journal of Physiology. Lung Cellular and Molecular Physiology. ajplung.00325.2017. PMID 28839104 DOI: 10.1152/Ajplung.00325.2017  1
2017 Jee K, Rodrigues M, Kashiwabuchi F, Applewhite BP, Han I, Lutty G, Goldberg MF, Semenza GL, Montaner S, Sodhi A. Expression of the angiogenic mediator, angiopoietin-like 4, in the eyes of patients with proliferative sickle retinopathy. Plos One. 12: e0183320. PMID 28832635 DOI: 10.1371/Journal.Pone.0183320  1
2017 Semenza GL. Next-gen cancer research. Journal of Molecular Medicine (Berlin, Germany). 95: 789. PMID 28707082 DOI: 10.1007/S00109-017-1567-8  0.01
2017 Samanta D, Semenza GL. Maintenance of redox homeostasis by hypoxia-inducible factors. Redox Biology. 13: 331-335. PMID 28624704 DOI: 10.1016/J.Redox.2017.05.022  1
2017 Pang Y, Yang C, Schovanek J, Wang H, Bullova P, Caisova V, Gupta G, Wolf KI, Semenza GL, Zhuang Z, Pacak K. Anthracyclines suppress pheochromocytoma cell characteristics, including metastasis, through inhibition of the hypoxia signaling pathway. Oncotarget. 8: 22313-22324. PMID 28423608 DOI: 10.18632/Oncotarget.16224  1
2017 Semenza GL. A Compendium of Proteins that Interact with HIF-1α. Experimental Cell Research. PMID 28336293 DOI: 10.1016/J.Yexcr.2017.03.041  0.01
2017 Lu H, Chen I, Shimoda LA, Park Y, Zhang C, Tran L, Zhang H, Semenza GL. Chemotherapy-Induced Ca(2+) Release Stimulates Breast Cancer Stem Cell Enrichment. Cell Reports. 18: 1946-1957. PMID 28228260 DOI: 10.1016/J.Celrep.2017.02.001  1
2017 Samanta D, Prabhakar NR, Semenza GL. Systems biology of oxygen homeostasis. Wiley Interdisciplinary Reviews. Systems Biology and Medicine. PMID 28221004 DOI: 10.1002/Wsbm.1382  1
2017 Ju JA, Godet I, Ye IC, Byun J, Jayatilaka H, Lee SJ, Xiang L, Samanta D, Lee MH, Wu PH, Wirtz D, Semenza GL, Gilkes DM. Hypoxia Selectively Enhances Integrin Receptor Expression to Promote Metastasis. Molecular Cancer Research : McR. PMID 28213554 DOI: 10.1158/1541-7786.Mcr-16-0338  1
2017 Peng YJ, Zhang X, Gridina A, Chupikova I, McCormick DL, Thomas RJ, Scammell TE, Kim G, Vasavda C, Nanduri J, Kumar GK, Semenza GL, Snyder SH, Prabhakar NR. Complementary roles of gasotransmitters CO and H2S in sleep apnea. Proceedings of the National Academy of Sciences of the United States of America. PMID 28115703 DOI: 10.1073/Pnas.1620717114  1
2016 Schito L, Semenza GL. Hypoxia-Inducible Factors: Master Regulators of Cancer Progression. Trends in Cancer. 2: 758-770. PMID 28741521 DOI: 10.1016/J.Trecan.2016.10.016  1
2016 Semenza GL. Hypoxia-inducible factors: coupling glucose metabolism and redox regulation with induction of the breast cancer stem cell phenotype. The Embo Journal. PMID 28007895 DOI: 10.15252/Embj.201695204  0.01
2016 Zeng M, Shen J, Liu Y, Lu LY, Ding K, Fortmann SD, Khan M, Wang J, Hackett SF, Semenza GL, Campochiaro PA. The HIF-1 antagonist acriflavine: visualization in retina and suppression of ocular neovascularization. Journal of Molecular Medicine (Berlin, Germany). PMID 28004126 DOI: 10.1007/S00109-016-1498-9  1
2016 Rodrigues M, Kashiwabuchi F, Deshpande M, Jee K, Goldberg MF, Lutty G, Semenza GL, Montaner S, Sodhi A. Expression Pattern of HIF-1α and VEGF Supports Circumferential Application of Scatter Laser for Proliferative Sickle Retinopathy. Investigative Ophthalmology & Visual Science. 57: 6739-6746. PMID 27951596 DOI: 10.1167/Iovs.16-19513  1
2016 Samanta D, Semenza GL. Serine Synthesis Helps Hypoxic Cancer Stem Cells Regulate Redox. Cancer Research. PMID 27811150 DOI: 10.1158/0008-5472.Can-16-1730  1
2016 Semenza GL. Serendipity, Generosity, and Inspiration. Cell. PMID 27634321 DOI: 10.1016/J.Cell.2016.08.045  0.01
2016 Kaelin WG, Ratcliffe PJ, Semenza GL. Pathways for Oxygen Regulation and Homeostasis: The 2016 Albert Lasker Basic Medical Research Award. Jama. PMID 27622845 DOI: 10.1001/Jama.2016.12386  0.01
2016 Zhang C, Zhi WI, Lu H, Samanta D, Chen I, Gabrielson E, Semenza GL. Hypoxia-inducible factors regulate pluripotency factor expression by ZNF217- and ALKBH5-mediated modulation of RNA methylation in breast cancer cells. Oncotarget. PMID 27590511 DOI: 10.18632/Oncotarget.11743  1
2016 Elgogary A, Xu Q, Poore B, Alt J, Zimmermann SC, Zhao L, Fu J, Chen B, Xia S, Liu Y, Neisser M, Nguyen C, Lee R, Park JK, Reyes J, ... ... Semenza GL, et al. Combination therapy with BPTES nanoparticles and metformin targets the metabolic heterogeneity of pancreatic cancer. Proceedings of the National Academy of Sciences of the United States of America. PMID 27559084 DOI: 10.1073/Pnas.1611406113  1
2016 Yuan G, Peng YJ, Khan SA, Nanduri J, Singh A, Vasavda C, Semenza GL, Kumar GK, Snyder SH, Prabhakar NR. H2S production by reactive oxygen species in the carotid body triggers hypertension in a rodent model of sleep apnea. Science Signaling. 9: ra80. PMID 27531649 DOI: 10.1126/Scisignal.Aaf3204  1
2016 Nanduri J, Peng YJ, Wang N, Khan SA, Semenza GL, Kumar GK, Prabhakar NR. Epigenetic regulation of redox state mediates persistent cardiorespiratory abnormalities after long-term intermittent hypoxia. The Journal of Physiology. PMID 27506145 DOI: 10.1113/Jp272346  1
2016 Samanta D, Park Y, Andrabi SA, Shelton LM, Gilkes DM, Semenza GL. PHGDH Expression is Required for Mitochondrial Redox Homeostasis, Breast Cancer Stem Cell Maintenance and Lung Metastasis. Cancer Research. PMID 27280394 DOI: 10.1158/0008-5472.Can-16-0530  1
2016 Bullen JW, Tchernyshyov I, Holewinski RJ, DeVine L, Wu F, Venkatraman V, Kass DL, Cole RN, Van Eyk J, Semenza GL. Protein kinase A-dependent phosphorylation stimulates the transcriptional activity of hypoxia-inducible factor 1. Science Signaling. 9: ra56. PMID 27245613 DOI: 10.1126/Scisignal.Aaf0583  1
2016 Zhang C, Samanta D, Lu H, Bullen JW, Zhang H, Chen I, He X, Semenza GL. Hypoxia induces the breast cancer stem cell phenotype by HIF-dependent and ALKBH5-mediated m6A-demethylation of NANOG mRNA. Proceedings of the National Academy of Sciences of the United States of America. PMID 27001847 DOI: 10.1073/Pnas.1602883113  1
2016 Klionsky DJ, Abdelmohsen K, Abe A, Abedin J, Abeliovich H, Arozena AA, Adachi H, Adams CM, Adams PD, Adeli K, Adhihetty PJ, Adler SG, Agam G, Agarwal R, Aghi MK, ... ... Semenza GL, et al. Erratum to: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (Autophagy, 12, 1, 1-222, 10.1080/15548627.2015.1100356 Autophagy. 12: 443-443. PMID 26902590 DOI: 10.1080/15548627.2016.1147886  1
2016 Luo W, Chen I, Chen Y, Alkam D, Wang Y, Semenza GL. PRDX2 and PRDX4 are negative regulators of hypoxia-inducible factors under conditions of prolonged hypoxia. Oncotarget. PMID 26837221 DOI: 10.18632/Oncotarget.7142  1
2016 Semenza GL. Novel strategies for cancer therapy. Journal of Molecular Medicine (Berlin, Germany). 94: 119-20. PMID 26780330 DOI: 10.1007/S00109-016-1379-2  0.01
2016 Hu K, Babapoor-Farrokhran S, Rodrigues M, Deshpande M, Puchner B, Kashiwabuchi F, Hassan SJ, Asnaghi L, Handa JT, Merbs S, Eberhart CG, Semenza GL, Montaner S, Sodhi A. Hypoxia-inducible factor 1 upregulation of both VEGF and ANGPTL4 is required to promote the angiogenic phenotype in uveal melanoma. Oncotarget. PMID 26761211 DOI: 10.18632/Oncotarget.6868  1
2016 Semenza GL, Ruvolo PP. Introduction to tumor microenvironment regulation of cancer cell survival, metastasis, inflammation, and immune surveillance. Biochimica Et Biophysica Acta. 1863: 379-81. PMID 26721622 DOI: 10.1016/J.Bbamcr.2015.12.015  0.01
2016 Johns RA, Takimoto E, Meuchel LW, Elsaigh E, Zhang A, Heller NM, Semenza GL, Yamaji-Kegan K. Hypoxia-Inducible Factor 1α Is a Critical Downstream Mediator for Hypoxia-Induced Mitogenic Factor (FIZZ1/RELMα)-Induced Pulmonary Hypertension. Arteriosclerosis, Thrombosis, and Vascular Biology. 36: 134-44. PMID 26586659 DOI: 10.1161/Atvbaha.115.306710  1
2016 Semenza GL. Dynamic regulation of stem cell specification and maintenance by hypoxia-inducible factors. Molecular Aspects of Medicine. 47: 15-23. PMID 26549347 DOI: 10.1016/j.mam.2015.09.004  0.01
2016 Prabhakar NR, Semenza GL. Regulation of carotid body oxygen sensing by hypoxia-inducible factors. PflüGers Archiv : European Journal of Physiology. 468: 71-5. PMID 26265380 DOI: 10.1007/S00424-015-1719-Z  1
2016 Semenza GL. The hypoxic tumor microenvironment: A driving force for breast cancer progression. Biochimica Et Biophysica Acta. 1863: 382-91. PMID 26079100 DOI: 10.1016/J.Bbamcr.2015.05.036  0.01
2016 Semenza GL. Targeting hypoxia-inducible factor 1 to stimulate tissue vascularization. Journal of Investigative Medicine : the Official Publication of the American Federation For Clinical Research. 64: 361-3. PMID 25955799 DOI: 10.1097/Jim.0000000000000206  0.01
2016 Zhi W, Huang C, Gabrielson E, Tully E, Cimino-Mathews A, Santa-Maria C, Jeter S, Kai C, Semenza G, Stearns V. Abstract P3-07-62: Association of overexpression of hypoxia inducible factor 1α with response to neoadjuvant chemotherapy in early stage breast cancer Cancer Research. 76. DOI: 10.1158/1538-7445.Sabcs15-P3-07-62  1
2015 Zhang H, Lu H, Xiang L, Bullen JW, Zhang C, Samanta D, Gilkes DM, He J, Semenza GL. HIF-1 regulates CD47 expression in breast cancer cells to promote evasion of phagocytosis and maintenance of cancer stem cells. Proceedings of the National Academy of Sciences of the United States of America. PMID 26512116 DOI: 10.1073/Pnas.1520032112  1
2015 Hubbi ME, Semenza GL. Regulation of cell proliferation by hypoxia-inducible factors. American Journal of Physiology. Cell Physiology. 309: C775-82. PMID 26491052 DOI: 10.1152/Ajpcell.00279.2015  1
2015 Semenza GL. Regulation of the breast cancer stem cell phenotype by hypoxia-inducible factors. Clinical Science (London, England : 1979). 129: 1037-45. PMID 26405042 DOI: 10.1042/CS20150451  0.01
2015 Semenza GL. AJP-Cell Theme: Cellular Responses to Hypoxia. American Journal of Physiology. Cell Physiology. 309: C349. PMID 26374688 DOI: 10.1152/Ajpcell.Zh0-7805-Editorial.2015  0.01
2015 Prabhakar NR, Semenza GL. Oxygen Sensing and Homeostasis. Physiology (Bethesda, Md.). 30: 340-8. PMID 26328879 DOI: 10.1152/Physiol.00022.2015  1
2015 Ganten D, Semenza G, Sommer T. 151 years Berliner Klinische Wochenschrift and the 20th anniversary of the Journal of Molecular Medicine. Journal of Molecular Medicine (Berlin, Germany). 93: 935-6. PMID 26260526 DOI: 10.1007/S00109-015-1324-9  1
2015 Lu H, Samanta D, Xiang L, Zhang H, Hu H, Chen I, Bullen JW, Semenza GL. Chemotherapy triggers HIF-1-dependent glutathione synthesis and copper chelation that induces the breast cancer stem cell phenotype. Proceedings of the National Academy of Sciences of the United States of America. 112: E4600-9. PMID 26229077 DOI: 10.1073/Pnas.1513433112  1
2015 Ma T, Patel H, Babapoor-Farrokhran S, Franklin R, Semenza GL, Sodhi A, Montaner S. KSHV induces aerobic glycolysis and angiogenesis through HIF-1-dependent upregulation of pyruvate kinase 2 in Kaposi's sarcoma. Angiogenesis. PMID 26092770 DOI: 10.1007/S10456-015-9475-4  1
2015 Xiang L, Gilkes DM, Hu H, Luo W, Bullen JW, Liang H, Semenza GL. HIF-1α and TAZ serve as reciprocal co-activators in human breast cancer cells. Oncotarget. 6: 11768-78. PMID 26059435 DOI: 10.18632/Oncotarget.4190  1
2015 Babapoor-Farrokhran S, Jee K, Puchner B, Hassan SJ, Xin X, Rodrigues M, Kashiwabuchi F, Ma T, Hu K, Deshpande M, Daoud Y, Solomon S, Wenick A, Lutty GA, Semenza GL, et al. Angiopoietin-like 4 is a potent angiogenic factor and a novel therapeutic target for patients with proliferative diabetic retinopathy. Proceedings of the National Academy of Sciences of the United States of America. 112: E3030-9. PMID 26039997 DOI: 10.1073/Pnas.1423765112  1
2015 Semenza GL, Prabhakar NR. Neural regulation of hypoxia-inducible factors and redox state drives the pathogenesis of hypertension in a rodent model of sleep apnea. Journal of Applied Physiology (Bethesda, Md. : 1985). 119: 1152-6. PMID 25953833 DOI: 10.1152/Japplphysiol.00162.2015  1
2015 Hubbi ME, Semenza GL. An essential role for chaperone-mediated autophagy in cell cycle progression. Autophagy. 11: 850-1. PMID 25945892 DOI: 10.1080/15548627.2015.1037063  1
2015 Yuan G, Vasavda C, Peng YJ, Makarenko VV, Raghuraman G, Nanduri J, Gadalla MM, Semenza GL, Kumar GK, Snyder SH, Prabhakar NR. Protein kinase G-regulated production of H2S governs oxygen sensing. Science Signaling. 8: ra37. PMID 25900831 DOI: 10.1126/Scisignal.2005846  1
2015 Wang J, Fu X, Yang K, Jiang Q, Chen Y, Jia J, Duan X, Wang EW, He J, Ran P, Zhong N, Semenza GL, Lu W. Hypoxia inducible factor-1-dependent up-regulation of BMP4 mediates hypoxia-induced increase of TRPC expression in PASMCs. Cardiovascular Research. 107: 108-18. PMID 25824146 DOI: 10.1093/Cvr/Cvv122  1
2015 Nanduri J, Vaddi DR, Khan SA, Wang N, Makarenko V, Semenza GL, Prabhakar NR. HIF-1α activation by intermittent hypoxia requires NADPH oxidase stimulation by xanthine oxidase. Plos One. 10: e0119762. PMID 25751622 DOI: 10.1371/Journal.Pone.0119762  1
2015 Liu ZJ, Semenza GL, Zhang HF. Hypoxia-inducible factor 1 and breast cancer metastasis. Journal of Zhejiang University. Science. B. 16: 32-43. PMID 25559953 DOI: 10.1631/Jzus.B1400221  0.08
2015 Luo W, Semenza GL. Abstract 525: PHD3-mediated prolyl hydroxylation of non-muscle actin impairs polymerization and cell motility Cancer Research. 75: 525-525. DOI: 10.1158/1538-7445.Am2015-525  1
2015 Lu H, Samanta D, Xiang L, Zhang H, Hu H, Chen I, Bullen JW, Semenza GL. Chemotherapy triggers HIF-1-dependent glutathione synthesis and copper chelation that induces the breast cancer stem cell phenotype Proceedings of the National Academy of Sciences of the United States of America. 112: E4600-E4609. DOI: 10.1073/pnas.1513433112  1
2014 Xiang L, Gilkes DM, Hu H, Takano N, Luo W, Lu H, Bullen JW, Samanta D, Liang H, Semenza GL. Hypoxia-inducible factor 1 mediates TAZ expression and nuclear localization to induce the breast cancer stem cell phenotype. Oncotarget. 5: 12509-27. PMID 25587023 DOI: 10.18632/Oncotarget.2997  1
2014 Samanta D, Gilkes DM, Chaturvedi P, Xiang L, Semenza GL. Hypoxia-inducible factors are required for chemotherapy resistance of breast cancer stem cells. Proceedings of the National Academy of Sciences of the United States of America. 111: E5429-38. PMID 25453096 DOI: 10.1073/Pnas.1421438111  1
2014 Hu H, Takano N, Xiang L, Gilkes DM, Luo W, Semenza GL. Hypoxia-inducible factors enhance glutamate signaling in cancer cells. Oncotarget. 5: 8853-68. PMID 25326682 DOI: 10.18632/Oncotarget.2593  1
2014 Chapiro J, Sur S, Savic LJ, Ganapathy-Kanniappan S, Reyes J, Duran R, Thiruganasambandam SC, Moats CR, Lin M, Luo W, Tran PT, Herman JM, Semenza GL, Ewald AJ, Vogelstein B, et al. Systemic delivery of microencapsulated 3-bromopyruvate for the therapy of pancreatic cancer. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 20: 6406-17. PMID 25326230 DOI: 10.1158/1078-0432.Ccr-14-1271  1
2014 Huang D, Li T, Li X, Zhang L, Sun L, He X, Zhong X, Jia D, Song L, Semenza GL, Gao P, Zhang H. HIF-1-mediated suppression of acyl-CoA dehydrogenases and fatty acid oxidation is critical for cancer progression. Cell Reports. 8: 1930-42. PMID 25242319 DOI: 10.1016/J.Celrep.2014.08.028  1
2014 Lorenzo FR, Huff C, Myllymäki M, Olenchock B, Swierczek S, Tashi T, Gordeuk V, Wuren T, Ri-Li G, McClain DA, Khan TM, Koul PA, Guchhait P, Salama ME, Xing J, ... Semenza GL, et al. A genetic mechanism for Tibetan high-altitude adaptation. Nature Genetics. 46: 951-6. PMID 25129147 DOI: 10.1038/Ng.3067  1
2014 Luo W, Lin B, Wang Y, Zhong J, O'Meally R, Cole RN, Pandey A, Levchenko A, Semenza GL. PHD3-mediated prolyl hydroxylation of nonmuscle actin impairs polymerization and cell motility. Molecular Biology of the Cell. 25: 2788-96. PMID 25079693 DOI: 10.1091/Mbc.E14-02-0775  1
2014 Hubbi ME, Gilkes DM, Hu H, Kshitiz, Ahmed I, Semenza GL. Cyclin-dependent kinases regulate lysosomal degradation of hypoxia-inducible factor 1α to promote cell-cycle progression. Proceedings of the National Academy of Sciences of the United States of America. 111: E3325-34. PMID 25071185 DOI: 10.1073/Pnas.1412840111  1
2014 Takano N, Sarfraz Y, Gilkes DM, Chaturvedi P, Xiang L, Suematsu M, Zagzag D, Semenza GL. Decreased expression of cystathionine β-synthase promotes glioma tumorigenesis. Molecular Cancer Research : McR. 12: 1398-406. PMID 24994751 DOI: 10.1158/1541-7786.Mcr-14-0184  1
2014 Peng YJ, Yuan G, Khan S, Nanduri J, Makarenko VV, Reddy VD, Vasavda C, Kumar GK, Semenza GL, Prabhakar NR. Regulation of hypoxia-inducible factor-α isoforms and redox state by carotid body neural activity in rats. The Journal of Physiology. 592: 3841-58. PMID 24973414 DOI: 10.1113/Jphysiol.2014.273789  1
2014 Wang T, Gilkes DM, Takano N, Xiang L, Luo W, Bishop CJ, Chaturvedi P, Green JJ, Semenza GL. Hypoxia-inducible factors and RAB22A mediate formation of microvesicles that stimulate breast cancer invasion and metastasis. Proceedings of the National Academy of Sciences of the United States of America. 111: E3234-42. PMID 24938788 DOI: 10.1073/Pnas.1410041111  1
2014 Jiang X, Sung YK, Tian W, Qian J, Semenza GL, Nicolls MR. Graft microvascular disease in solid organ transplantation. Journal of Molecular Medicine (Berlin, Germany). 92: 797-810. PMID 24880953 DOI: 10.1007/S00109-014-1173-Y  1
2014 Yang C, Jiang L, Zhang H, Shimoda LA, DeBerardinis RJ, Semenza GL. Analysis of hypoxia-induced metabolic reprogramming. Methods in Enzymology. 542: 425-55. PMID 24862279 DOI: 10.1016/B978-0-12-416618-9.00022-4  1
2014 Gilkes DM, Semenza GL, Wirtz D. Hypoxia and the extracellular matrix: drivers of tumour metastasis. Nature Reviews. Cancer. 14: 430-9. PMID 24827502 DOI: 10.1038/Nrc3726  1
2014 Chaturvedi P, Gilkes DM, Takano N, Semenza GL. Hypoxia-inducible factor-dependent signaling between triple-negative breast cancer cells and mesenchymal stem cells promotes macrophage recruitment. Proceedings of the National Academy of Sciences of the United States of America. 111: E2120-9. PMID 24799675 DOI: 10.1073/Pnas.1406655111  1
2014 Takano N, Peng YJ, Kumar GK, Luo W, Hu H, Shimoda LA, Suematsu M, Prabhakar NR, Semenza GL. Hypoxia-inducible factors regulate human and rat cystathionine β-synthase gene expression. The Biochemical Journal. 458: 203-11. PMID 24328859 DOI: 10.1042/Bj20131350  1
2014 Gilkes DM, Xiang L, Lee SJ, Chaturvedi P, Hubbi ME, Wirtz D, Semenza GL. Hypoxia-inducible factors mediate coordinated RhoA-ROCK1 expression and signaling in breast cancer cells. Proceedings of the National Academy of Sciences of the United States of America. 111: E384-93. PMID 24324133 DOI: 10.1073/Pnas.1321510111  1
2014 Xiang L, Gilkes DM, Chaturvedi P, Luo W, Hu H, Takano N, Liang H, Semenza GL. Ganetespib blocks HIF-1 activity and inhibits tumor growth, vascularization, stem cell maintenance, invasion, and metastasis in orthotopic mouse models of triple-negative breast cancer. Journal of Molecular Medicine (Berlin, Germany). 92: 151-64. PMID 24248265 DOI: 10.1007/S00109-013-1102-5  1
2014 Jiang X, Malkovskiy AV, Tian W, Sung YK, Sun W, Hsu JL, Manickam S, Wagh D, Joubert LM, Semenza GL, Rajadas J, Nicolls MR. Promotion of airway anastomotic microvascular regeneration and alleviation of airway ischemia by deferoxamine nanoparticles. Biomaterials. 35: 803-13. PMID 24161166 DOI: 10.1016/J.Biomaterials.2013.09.092  1
2014 Semenza GL. Hypoxia-inducible factor 1 and cardiovascular disease. Annual Review of Physiology. 76: 39-56. PMID 23988176 DOI: 10.1146/Annurev-Physiol-021113-170322  0.01
2014 Semenza GL. Oxygen sensing, hypoxia-inducible factors, and disease pathophysiology. Annual Review of Pathology. 9: 47-71. PMID 23937437 DOI: 10.1146/annurev-pathol-012513-104720  0.01
2013 Gilkes DM, Semenza GL. Role of hypoxia-inducible factors in breast cancer metastasis. Future Oncology (London, England). 9: 1623-36. PMID 24156323 DOI: 10.2217/Fon.13.92  1
2013 Iwase T, Fu J, Yoshida T, Muramatsu D, Miki A, Hashida N, Lu L, Oveson B, Lima e Silva R, Seidel C, Yang M, Connelly S, Shen J, Han B, Wu M, ... Semenza GL, et al. Sustained delivery of a HIF-1 antagonist for ocular neovascularization. Journal of Controlled Release : Official Journal of the Controlled Release Society. 172: 625-33. PMID 24126220 DOI: 10.1016/J.Jconrel.2013.10.008  1
2013 Cai Z, Luo W, Zhan H, Semenza GL. Hypoxia-inducible factor 1 is required for remote ischemic preconditioning of the heart. Proceedings of the National Academy of Sciences of the United States of America. 110: 17462-7. PMID 24101519 DOI: 10.1073/Pnas.1317158110  1
2013 Semenza GL. HIF-1 mediates metabolic responses to intratumoral hypoxia and oncogenic mutations. The Journal of Clinical Investigation. 123: 3664-71. PMID 23999440 DOI: 10.1172/Jci67230  0.01
2013 Chen Z, Barbi J, Bu S, Yang HY, Li Z, Gao Y, Jinasena D, Fu J, Lin F, Chen C, Zhang J, Yu N, Li X, Shan Z, Nie J, ... ... Semenza GL, et al. The ubiquitin ligase Stub1 negatively modulates regulatory T cell suppressive activity by promoting degradation of the transcription factor Foxp3. Immunity. 39: 272-85. PMID 23973223 DOI: 10.1016/J.Immuni.2013.08.006  1
2013 Xin X, Rodrigues M, Umapathi M, Kashiwabuchi F, Ma T, Babapoor-Farrokhran S, Wang S, Hu J, Bhutto I, Welsbie DS, Duh EJ, Handa JT, Eberhart CG, Lutty G, Semenza GL, et al. Hypoxic retinal Muller cells promote vascular permeability by HIF-1-dependent up-regulation of angiopoietin-like 4. Proceedings of the National Academy of Sciences of the United States of America. 110: E3425-34. PMID 23959876 DOI: 10.1073/Pnas.1217091110  1
2013 Rodrigues M, Xin X, Jee K, Babapoor-Farrokhran S, Kashiwabuchi F, Ma T, Bhutto I, Hassan SJ, Daoud Y, Baranano D, Solomon S, Lutty G, Semenza GL, Montaner S, Sodhi A. VEGF secreted by hypoxic Müller cells induces MMP-2 expression and activity in endothelial cells to promote retinal neovascularization in proliferative diabetic retinopathy. Diabetes. 62: 3863-73. PMID 23884892 DOI: 10.2337/Db13-0014  1
2013 Jiang X, Hsu JL, Tian W, Yuan K, Olcholski M, Perez Vde J, Semenza GL, Nicolls MR. Tie2-dependent VHL knockdown promotes airway microvascular regeneration and attenuates invasive growth of Aspergillus fumigatus. Journal of Molecular Medicine (Berlin, Germany). 91: 1081-93. PMID 23797537 DOI: 10.1007/S00109-013-1063-8  1
2013 Du J, Liu L, Lay F, Wang Q, Dou C, Zhang X, Hosseini SM, Simon A, Rees DJ, Ahmed AK, Sebastian R, Sarkar K, Milner S, Marti GP, Semenza GL, et al. Combination of HIF-1α gene transfection and HIF-1-Activated bone marrow-derived angiogenic cell infusion improves burn wound healing in aged mice Gene Therapy. 20: 1070-1076. PMID 23784441 DOI: 10.1038/Gt.2013.32  1
2013 Hubbi ME, Hu H, Kshitiz, Gilkes DM, Semenza GL. Sirtuin-7 inhibits the activity of hypoxia-inducible factors. The Journal of Biological Chemistry. 288: 20768-75. PMID 23750001 DOI: 10.1074/Jbc.M113.476903  1
2013 Bohuslavova R, Skvorova L, Sedmera D, Semenza GL, Pavlinkova G. Increased susceptibility of HIF-1α heterozygous-null mice to cardiovascular malformations associated with maternal diabetes. Journal of Molecular and Cellular Cardiology. 60: 129-41. PMID 23619295 DOI: 10.1016/J.Yjmcc.2013.04.015  0.01
2013 Agus DB, Alexander JF, Arap W, Ashili S, Aslan JE, Austin RH, Backman V, Bethel KJ, Bonneau R, Chen WC, Chen-Tanyolac C, Choi NC, Curley SA, Dallas M, ... ... Semenza GL, et al. A physical sciences network characterization of non-tumorigenic and metastatic cells. Scientific Reports. 3: 1449. PMID 23618955 DOI: 10.1038/Srep01449  1
2013 Yuan G, Peng YJ, Reddy VD, Makarenko VV, Nanduri J, Khan SA, Garcia JA, Kumar GK, Semenza GL, Prabhakar NR. Mutual antagonism between hypoxia-inducible factors 1α and 2α regulates oxygen sensing and cardio-respiratory homeostasis. Proceedings of the National Academy of Sciences of the United States of America. 110: E1788-96. PMID 23610397 DOI: 10.1073/Pnas.1305961110  1
2013 Gilkes DM, Chaturvedi P, Bajpai S, Wong CC, Wei H, Pitcairn S, Hubbi ME, Wirtz D, Semenza GL. Collagen prolyl hydroxylases are essential for breast cancer metastasis. Cancer Research. 73: 3285-96. PMID 23539444 DOI: 10.1158/0008-5472.Can-12-3963  1
2013 Semenza GL. Advances in cancer biology and therapy. Journal of Molecular Medicine (Berlin, Germany). 91: 409. PMID 23515622 DOI: 10.1007/S00109-013-1024-2  0.01
2013 Hubbi ME, Hu H, Kshitiz, Ahmed I, Levchenko A, Semenza GL. Chaperone-mediated autophagy targets hypoxia-inducible factor-1α (HIF-1α) for lysosomal degradation. The Journal of Biological Chemistry. 288: 10703-14. PMID 23457305 DOI: 10.1074/Jbc.M112.414771  1
2013 Semenza GL. Blood vessels, disease pathogenesis, and novel therapies. Journal of Molecular Medicine (Berlin, Germany). 91: 283. PMID 23430241 DOI: 10.1007/S00109-013-1009-1  0.01
2013 Gilkes DM, Bajpai S, Chaturvedi P, Wirtz D, Semenza GL. Hypoxia-inducible factor 1 (HIF-1) promotes extracellular matrix remodeling under hypoxic conditions by inducing P4HA1, P4HA2, and PLOD2 expression in fibroblasts. The Journal of Biological Chemistry. 288: 10819-29. PMID 23423382 DOI: 10.1074/Jbc.M112.442939  1
2013 Pisarcik S, Maylor J, Lu W, Yun X, Undem C, Sylvester JT, Semenza GL, Shimoda LA. Activation of hypoxia-inducible factor-1 in pulmonary arterial smooth muscle cells by endothelin-1. American Journal of Physiology. Lung Cellular and Molecular Physiology. 304: L549-61. PMID 23418090 DOI: 10.1152/Ajplung.00081.2012  1
2013 Hubbi ME, Kshitiz, Gilkes DM, Rey S, Wong CC, Luo W, Kim DH, Dang CV, Levchenko A, Semenza GL. A nontranscriptional role for HIF-1α as a direct inhibitor of DNA replication Science Signaling. 6. PMID 23405012 DOI: 10.1126/Scisignal.2003417  1
2013 Gilkes DM, Bajpai S, Wong CC, Chaturvedi P, Hubbi ME, Wirtz D, Semenza GL. Procollagen lysyl hydroxylase 2 is essential for hypoxia-induced breast cancer metastasis. Molecular Cancer Research : McR. 11: 456-66. PMID 23378577 DOI: 10.1158/1541-7786.Mcr-12-0629  1
2013 Drager LF, Yao Q, Hernandez KL, Shin MK, Bevans-Fonti S, Gay J, Sussan TE, Jun JC, Myers AC, Olivecrona G, Schwartz AR, Halberg N, Scherer PE, Semenza GL, Powell DR, et al. Chronic intermittent hypoxia induces atherosclerosis via activation of adipose angiopoietin-like 4. American Journal of Respiratory and Critical Care Medicine. 188: 240-8. PMID 23328524 DOI: 10.1164/Rccm.201209-1688Oc  1
2013 Chaturvedi P, Gilkes DM, Wong CC, Luo W, Zhang H, Wei H, Takano N, Schito L, Levchenko A, Semenza GL. Hypoxia-inducible factor-dependent breast cancer-mesenchymal stem cell bidirectional signaling promotes metastasis. The Journal of Clinical Investigation. 123: 189-205. PMID 23318994 DOI: 10.1172/Jci64993  1
2013 Semenza GL. Cancer-stromal cell interactions mediated by hypoxia-inducible factors promote angiogenesis, lymphangiogenesis, and metastasis. Oncogene. 32: 4057-63. PMID 23222717 DOI: 10.1038/Onc.2012.578  0.01
2013 Chaturvedi P, Gilkes DM, Wong CCL, Kshitiz, Luo W, Zhang H, Wei H, Takano N, Schito L, Levchenko A, Semenza GL. Erratum: Hypoxia-inducible factor-dependent breast cancer-mesenchymal stem cell bidirectional signaling promotes metastasis (Journal of Clinical Investigation (2013) 123: 1 (189-205) DOI: 10.1172/JCI64993) Journal of Clinical Investigation. 123. DOI: 10.1172/Jci69244  1
2013 Gilkes DM, Chaturvedi P, Wong C, Bajpai S, Wei H, Hubbi M, Wirtz D, Semenza G. Abstract A3: Collagen hydroxylases are essential for breast cancer metastasis Cancer Research. 73. DOI: 10.1158/1538-7445.Tim2013-A3  1
2013 Chaturvedi P, Gilkes D, Semenza G. Abstract 505: Hypoxia inducible factor-dependent breast cancer-mesenchymal stem cell bidirectional signaling promotes metastasis. Cancer Research. 73: 505-505. DOI: 10.1158/1538-7445.Am2013-505  1
2013 Gilkes DM, Chaturvedi P, Bajpai S, Hubbi M, Wirtz D, Semenza G. Abstract 3937: Collagen prolyl hydroxylases are essential for breast cancer metastasis. Cancer Research. 73: 3937-3937. DOI: 10.1158/1538-7445.Am2013-3937  1
2013 Luo W, Chang R, Zhong J, Pandey A, Semenza GL. Abstract 2319: Histone demethylase JMJD2C is a coactivator for hypoxia-inducible factor 1 that is required for breast cancer progression. Cancer Research. 73: 2319-2319. DOI: 10.1158/1538-7445.Am2013-2319  1
2012 Luo W, Chang R, Zhong J, Pandey A, Semenza GL. Histone demethylase JMJD2C is a coactivator for hypoxia-inducible factor 1 that is required for breast cancer progression. Proceedings of the National Academy of Sciences of the United States of America. 109: E3367-76. PMID 23129632 DOI: 10.1073/Pnas.1217394109  1
2012 Semenza GL, Prabhakar NR. The role of hypoxia-inducible factors in oxygen sensing by the carotid body. Advances in Experimental Medicine and Biology. 758: 1-5. PMID 23080136 DOI: 10.1007/978-94-007-4584-1_1  1
2012 Schito L, Rey S, Tafani M, Zhang H, Wong CCL, Russo A, Russo MA, Semenza GL. Hypoxia-inducible factor 1-dependent expression of platelet-derived growth factor B promotes lymphatic metastasis of hypoxic breast cancer cells Proceedings of the National Academy of Sciences of the United States of America. 109: E2707-E2716. PMID 23012449 DOI: 10.1073/Pnas.1214019109  1
2012 Krishnamachary B, Penet MF, Nimmagadda S, Mironchik Y, Raman V, Solaiyappan M, Semenza GL, Pomper MG, Bhujwalla ZM. Hypoxia regulates CD44 and its variant isoforms through HIF-1α in triple negative breast cancer. Plos One. 7: e44078. PMID 22937154 DOI: 10.1371/Journal.Pone.0044078  1
2012 Semenza GL. Molecular mechanisms mediating metastasis of hypoxic breast cancer cells. Trends in Molecular Medicine. 18: 534-43. PMID 22921864 DOI: 10.1016/J.Molmed.2012.08.001  0.01
2012 Luo W, Semenza GL. Emerging roles of PKM2 in cell metabolism and cancer progression. Trends in Endocrinology and Metabolism: Tem. 23: 560-6. PMID 22824010 DOI: 10.1016/J.Tem.2012.06.010  1
2012 Prabhakar NR, Semenza GL. Adaptive and maladaptive cardiorespiratory responses to continuous and intermittent hypoxia mediated by hypoxia-inducible factors 1 and 2. Physiological Reviews. 92: 967-1003. PMID 22811423 DOI: 10.1152/Physrev.00030.2011  1
2012 Sarkar K, Cai Z, Gupta R, Parajuli N, Fox-Talbot K, Darshan MS, Gonzalez FJ, Semenza GL. Hypoxia-inducible factor 1 transcriptional activity in endothelial cells is required for acute phase cardioprotection induced by ischemic preconditioning. Proceedings of the National Academy of Sciences of the United States of America. 109: 10504-9. PMID 22699503 DOI: 10.1073/Pnas.1208314109  1
2012 Kshitiz, Hubbi ME, Ahn EH, Downey J, Afzal J, Kim DH, Rey S, Chang C, Kundu A, Semenza GL, Abraham RM, Levchenko A. Matrix rigidity controls endothelial differentiation and morphogenesis of cardiac precursors. Science Signaling. 5: ra41. PMID 22669846 DOI: 10.1126/Scisignal.2003002  1
2012 Wei H, Bedja D, Koitabashi N, Xing D, Chen J, Fox-Talbot K, Rouf R, Chen S, Steenbergen C, Harmon JW, Dietz HC, Gabrielson KL, Kass DA, Semenza GL. Endothelial expression of hypoxia-inducible factor 1 protects the murine heart and aorta from pressure overload by suppression of TGF-β signaling. Proceedings of the National Academy of Sciences of the United States of America. 109: E841-50. PMID 22403061 DOI: 10.1073/Pnas.1202081109  1
2012 Semenza GL. Hypoxia-inducible factors: mediators of cancer progression and targets for cancer therapy. Trends in Pharmacological Sciences. 33: 207-14. PMID 22398146 DOI: 10.1016/J.Tips.2012.01.005  0.01
2012 Semenza GL, Prabhakar NR. Gas biology: small molecular medicine. Journal of Molecular Medicine (Berlin, Germany). 90: 213-5. PMID 22349395 DOI: 10.1007/S00109-012-0877-0  1
2012 Prabhakar NR, Semenza GL. Gaseous messengers in oxygen sensing. Journal of Molecular Medicine (Berlin, Germany). 90: 265-72. PMID 22349394 DOI: 10.1007/S00109-012-0876-1  1
2012 Semenza GL. Hypoxia-inducible factors in physiology and medicine. Cell. 148: 399-408. PMID 22304911 DOI: 10.1016/J.Cell.2012.01.021  0.01
2012 Abud EM, Maylor J, Undem C, Punjabi A, Zaiman AL, Myers AC, Sylvester JT, Semenza GL, Shimoda LA. Digoxin inhibits development of hypoxic pulmonary hypertension in mice. Proceedings of the National Academy of Sciences of the United States of America. 109: 1239-44. PMID 22232678 DOI: 10.1073/Pnas.1120385109  1
2012 Nanduri J, Makarenko V, Reddy VD, Yuan G, Pawar A, Wang N, Khan SA, Zhang X, Kinsman B, Peng YJ, Kumar GK, Fox AP, Godley LA, Semenza GL, Prabhakar NR. Epigenetic regulation of hypoxic sensing disrupts cardiorespiratory homeostasis. Proceedings of the National Academy of Sciences of the United States of America. 109: 2515-20. PMID 22232674 DOI: 10.1073/Pnas.1120600109  1
2012 Wong CC, Zhang H, Gilkes DM, Chen J, Wei H, Chaturvedi P, Hubbi ME, Semenza GL. Inhibitors of hypoxia-inducible factor 1 block breast cancer metastatic niche formation and lung metastasis. Journal of Molecular Medicine (Berlin, Germany). 90: 803-15. PMID 22231744 DOI: 10.1007/S00109-011-0855-Y  1
2012 Hubbi ME, Gilkes DM, Baek JH, Semenza GL. Four-and-a-half LIM domain proteins inhibit transactivation by hypoxia-inducible factor 1. The Journal of Biological Chemistry. 287: 6139-49. PMID 22219185 DOI: 10.1074/Jbc.M111.278630  1
2012 Sarkar K, Rey S, Zhang X, Sebastian R, Marti GP, Fox-Talbot K, Cardona AV, Du J, Tan YS, Liu L, Lay F, Gonzalez FJ, Harmon JW, Semenza GL. Tie2-dependent knockout of HIF-1 impairs burn wound vascularization and homing of bone marrow-derived angiogenic cells. Cardiovascular Research. 93: 162-9. PMID 22028336 DOI: 10.1093/Cvr/Cvr282  1
2012 Zhang H, Wong CC, Wei H, Gilkes DM, Korangath P, Chaturvedi P, Schito L, Chen J, Krishnamachary B, Winnard PT, Raman V, Zhen L, Mitzner WA, Sukumar S, Semenza GL. HIF-1-dependent expression of angiopoietin-like 4 and L1CAM mediates vascular metastasis of hypoxic breast cancer cells to the lungs. Oncogene. 31: 1757-70. PMID 21860410 DOI: 10.1038/Onc.2011.365  1
2012 Kshitiz, Hubbi ME, Ahn EH, Downey J, Afzal J, Kim DH, Rey S, Chang C, Kundu A, Semenza GL, Abraham RM, Levchenko A. Matrix rigidity controls endothelial differentiation and morphogenesis of cardiac precursors (Science Signaling (2012) 5) Science Signaling. 5. DOI: 10.1126/Scisignal.5245Er6  1
2011 Suda T, Takubo K, Semenza GL. Metabolic regulation of hematopoietic stem cells in the hypoxic niche. Cell Stem Cell. 9: 298-310. PMID 21982230 DOI: 10.1016/J.Stem.2011.09.010  0.01
2011 Wong CC, Gilkes DM, Zhang H, Chen J, Wei H, Chaturvedi P, Fraley SI, Wong CM, Khoo US, Ng IO, Wirtz D, Semenza GL. Hypoxia-inducible factor 1 is a master regulator of breast cancer metastatic niche formation. Proceedings of the National Academy of Sciences of the United States of America. 108: 16369-74. PMID 21911388 DOI: 10.1073/Pnas.1113483108  1
2011 Dang EV, Barbi J, Yang HY, Jinasena D, Yu H, Zheng Y, Bordman Z, Fu J, Kim Y, Yen HR, Luo W, Zeller K, Shimoda L, Topalian SL, Semenza GL, et al. Control of TH17/Treg balance by hypoxia-inducible factor 1 Cell. 146: 772-784. PMID 21871655 DOI: 10.1016/J.Cell.2011.07.033  1
2011 Hattori H, Okuda K, Murase T, Shigetsura Y, Narise K, Semenza GL, Nagasawa H. Isolation, identification, and biological evaluation of HIF-1-modulating compounds from Brazilian green propolis. Bioorganic & Medicinal Chemistry. 19: 5392-401. PMID 21865046 DOI: 10.1016/J.Bmc.2011.07.060  1
2011 Semenza GL. Oxygen sensing, homeostasis, and disease. The New England Journal of Medicine. 365: 537-47. PMID 21830968 DOI: 10.1056/Nejmra1011165  0.01
2011 Semenza GL. Regulation of metabolism by hypoxia-inducible factor 1. Cold Spring Harbor Symposia On Quantitative Biology. 76: 347-53. PMID 21785006 DOI: 10.1101/Sqb.2011.76.010678  0.01
2011 Luo W, Semenza GL. Pyruvate kinase M2 regulates glucose metabolism by functioning as a coactivator for hypoxia-inducible factor 1 in cancer cells. Oncotarget. 2: 551-6. PMID 21709315 DOI: 10.18632/Oncotarget.299  1
2011 Semenza GL. Hypoxia. Cross talk between oxygen sensing and the cell cycle machinery. American Journal of Physiology. Cell Physiology. 301: C550-2. PMID 21677261 DOI: 10.1152/Ajpcell.00176.2011  0.01
2011 Hubbi ME, Luo W, Baek JH, Semenza GL. MCM proteins are negative regulators of hypoxia-inducible factor 1. Molecular Cell. 42: 700-12. PMID 21658608 DOI: 10.1016/J.Molcel.2011.03.029  1
2011 Luo W, Hu H, Chang R, Zhong J, Knabel M, O'Meally R, Cole RN, Pandey A, Semenza GL. Pyruvate kinase M2 is a PHD3-stimulated coactivator for hypoxia-inducible factor 1. Cell. 145: 732-44. PMID 21620138 DOI: 10.1016/J.Cell.2011.03.054  1
2011 Jiang X, Khan MA, Tian W, Beilke J, Natarajan R, Kosek J, Yoder MC, Semenza GL, Nicolls MR. Adenovirus-mediated HIF-1α gene transfer promotes repair of mouse airway allograft microvasculature and attenuates chronic rejection. The Journal of Clinical Investigation. 121: 2336-49. PMID 21606594 DOI: 10.1172/Jci46192  1
2011 Zhang X, Sarkar K, Rey S, Sebastian R, Andrikopoulou E, Marti GP, Fox-Talbot K, Semenza GL, Harmon JW. Aging impairs the mobilization and homing of bone marrow-derived angiogenic cells to burn wounds. Journal of Molecular Medicine (Berlin, Germany). 89: 985-95. PMID 21499736 DOI: 10.1007/S00109-011-0754-2  1
2011 Rangasamy T, Semenza GL, Georas SN. What is hypoxia-inducible factor-1 doing in the allergic lung? Allergy. 66: 815-7. PMID 21480925 DOI: 10.1111/j.1398-9995.2011.02593.x  1
2011 Rey S, Luo W, Shimoda LA, Semenza GL. Metabolic reprogramming by HIF-1 promotes the survival of bone marrow-derived angiogenic cells in ischemic tissue Blood. 117: 4988-4998. PMID 21389314 DOI: 10.1182/Blood-2010-11-321190  1
2011 Keswani SC, Bosch-Marcé M, Reed N, Fischer A, Semenza GL, Höke A. Nitric oxide prevents axonal degeneration by inducing HIF-1-dependent expression of erythropoietin. Proceedings of the National Academy of Sciences of the United States of America. 108: 4986-90. PMID 21383158 DOI: 10.1073/Pnas.1019591108  0.08
2011 Yuan G, Khan SA, Luo W, Nanduri J, Semenza GL, Prabhakar NR. Hypoxia-inducible factor 1 mediates increased expression of NADPH oxidase-2 in response to intermittent hypoxia. Journal of Cellular Physiology. 226: 2925-33. PMID 21302291 DOI: 10.1002/Jcp.22640  1
2011 Semenza GL. A return to cancer metabolism. Journal of Molecular Medicine (Berlin, Germany). 89: 203-4. PMID 21301793 DOI: 10.1007/S00109-011-0733-7  0.01
2011 Peng YJ, Nanduri J, Khan SA, Yuan G, Wang N, Kinsman B, Vaddi DR, Kumar GK, Garcia JA, Semenza GL, Prabhakar NR. Hypoxia-inducible factor 2α (HIF-2α) heterozygous-null mice exhibit exaggerated carotid body sensitivity to hypoxia, breathing instability, and hypertension. Proceedings of the National Academy of Sciences of the United States of America. 108: 3065-70. PMID 21288809 DOI: 10.1073/Pnas.1100064108  1
2011 Shimoda LA, Semenza GL. HIF and the lung: role of hypoxia-inducible factors in pulmonary development and disease. American Journal of Respiratory and Critical Care Medicine. 183: 152-6. PMID 21242594 DOI: 10.1164/Rccm.201009-1393Pp  1
2011 Kannan KB, Colorado I, Reino D, Palange D, Lu Q, Qin X, Abungu B, Watkins A, Caputo FJ, Xu DZ, Semenza GL, Deitch EA, Feinman R. Hypoxia-inducible factor plays a gut-injurious role in intestinal ischemia reperfusion injury. American Journal of Physiology. Gastrointestinal and Liver Physiology. 300: G853-61. PMID 21183660 DOI: 10.1152/Ajpgi.00459.2010  1
2011 Semenza GL. American Journal of Physiology-Cell Physiology theme: hypoxia. American Journal of Physiology. Cell Physiology. 300: C225. PMID 21084643 DOI: 10.1152/Ajpcell.00468.2010  0.01
2011 Semenza GL. Hypoxia-inducible factor 1: regulator of mitochondrial metabolism and mediator of ischemic preconditioning. Biochimica Et Biophysica Acta. 1813: 1263-8. PMID 20732359 DOI: 10.1016/J.Bbamcr.2010.08.006  0.01
2011 Korangath PC, Zhang H, Zhang Z, Huso D, Stearns V, Dang C, Semenza G, Sukumar S. Abstract 4088: Targeting glutamine metabolism in breast cancer Cancer Research. 71: 4088-4088. DOI: 10.1158/1538-7445.Am2011-4088  1
2011 Wong CCL, Gilkes D, Zhang H, Chen J, Chaturvedi P, Fraley S, Semenza GL. Abstract 1521: Hypoxia inducible factor is an important regulator of metastatic niche formation Cancer Research. 71: 1521-1521. DOI: 10.1158/1538-7445.Am2011-1521  1
2010 Guan Y, Ramasamy Reddy K, Zhu Q, Li Y, Lee K, Weerasinghe P, Prchal J, Semenza GL, Jing N. G-rich Oligonucleotides Inhibit HIF-1α and HIF-2α and Block Tumor Growth. Molecular Therapy : the Journal of the American Society of Gene Therapy. 18: 188-197. PMID 28178550 DOI: 10.1038/mt.2009.219  1
2010 Semenza GL. Oxygen homeostasis. Wiley Interdisciplinary Reviews. Systems Biology and Medicine. 2: 336-61. PMID 20836033 DOI: 10.1002/wsbm.69  0.01
2010 Feinman R, Deitch EA, Watkins AC, Abungu B, Colorado I, Kannan KB, Sheth SU, Caputo FJ, Lu Q, Ramanathan M, Attan S, Badami CD, Doucet D, Barlos D, Bosch-Marce M, ... Semenza GL, et al. HIF-1 mediates pathogenic inflammatory responses to intestinal ischemia-reperfusion injury. American Journal of Physiology. Gastrointestinal and Liver Physiology. 299: G833-43. PMID 20689059 DOI: 10.1152/Ajpgi.00065.2010  1
2010 Lee JS, Kim Y, Kim IS, Kim B, Choi HJ, Lee JM, Shin HJ, Kim JH, Kim JY, Seo SB, Lee H, Binda O, Gozani O, Semenza GL, Kim M, et al. Negative regulation of hypoxic responses via induced Reptin methylation. Molecular Cell. 39: 71-85. PMID 20603076 DOI: 10.1016/J.Molcel.2010.06.008  0.01
2010 Zhang X, Wei X, Liu L, Marti GP, Ghanamah MS, Arshad MJ, Strom L, Spence R, Jeng J, Milner S, Harmon JW, Semenza GL. Association of increasing burn severity in mice with delayed mobilization of circulating angiogenic cells. Archives of Surgery (Chicago, Ill. : 1960). 145: 259-66. PMID 20231626 DOI: 10.1001/Archsurg.2009.285  1
2010 Rey S, Semenza GL. Hypoxia-inducible factor-1-dependent mechanisms of vascularization and vascular remodelling Cardiovascular Research. 86: 236-242. PMID 20164116 DOI: 10.1093/Cvr/Cvq045  1
2010 Zhang X, Liu L, Wei X, Tan YS, Tong L, Chang R, Ghanamah MS, Reinblatt M, Marti GP, Harmon JW, Semenza GL. Impaired angiogenesis and mobilization of circulating angiogenic cells in HIF-1alpha heterozygous-null mice after burn wounding. Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society. 18: 193-201. PMID 20163569 DOI: 10.1111/J.1524-475X.2010.00570.X  1
2010 Yoon D, Okhotin DV, Kim B, Okhotina Y, Okhotin DJ, Miasnikova GY, Sergueeva AI, Polyakova LA, Maslow A, Lee Y, Semenza GL, Prchal JT, Gordeuk VR. Increased size of solid organs in patients with Chuvash polycythemia and in mice with altered expression of HIF-1alpha and HIF-2alpha. Journal of Molecular Medicine (Berlin, Germany). 88: 523-30. PMID 20140661 DOI: 10.1007/S00109-010-0599-0  1
2010 Le A, Cooper CR, Gouw AM, Dinavahi R, Maitra A, Deck LM, Royer RE, Vander Jagt DL, Semenza GL, Dang CV. Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression. Proceedings of the National Academy of Sciences of the United States of America. 107: 2037-42. PMID 20133848 DOI: 10.1073/Pnas.0914433107  1
2010 Yoshida T, Zhang H, Iwase T, Shen J, Semenza GL, Campochiaro PA. Digoxin inhibits retinal ischemia-induced HIF-1alpha expression and ocular neovascularization. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 24: 1759-67. PMID 20065104 DOI: 10.1096/Fj.09-145664  1
2010 Kojima H, Kobayashi A, Sakurai D, Kanno Y, Hase H, Takahashi R, Totsuka Y, Semenza GL, Sitkovsky MV, Kobata T. Differentiation stage-specific requirement in hypoxia-inducible factor-1alpha-regulated glycolytic pathway during murine B cell development in bone marrow. Journal of Immunology (Baltimore, Md. : 1950). 184: 154-63. PMID 19949104 DOI: 10.4049/Jimmunol.0800167  0.01
2010 Luo W, Zhong J, Chang R, Hu H, Pandey A, Semenza GL. Hsp70 and CHIP selectively mediate ubiquitination and degradation of hypoxia-inducible factor (HIF)-1alpha but Not HIF-2alpha. The Journal of Biological Chemistry. 285: 3651-63. PMID 19940151 DOI: 10.1074/Jbc.M109.068577  1
2010 Ugocsai P, Hohenstatt A, Paragh G, Liebisch G, Langmann T, Wolf Z, Weiss T, Groitl P, Dobner T, Kasprzak P, Göbölös L, Falkert A, Seelbach-Goebel B, Gellhaus A, Winterhager E, ... ... Semenza GL, et al. HIF-1beta determines ABCA1 expression under hypoxia in human macrophages. The International Journal of Biochemistry & Cell Biology. 42: 241-52. PMID 19828131 DOI: 10.1016/J.Biocel.2009.10.002  0.01
2010 Guan Y, Reddy KR, Zhu Q, Li Y, Lee K, Weerasinghe P, Prchal J, Semenza GL, Jing N. G-rich oligonucleotides inhibit HIF-1alpha and HIF-2alpha and block tumor growth. Molecular Therapy : the Journal of the American Society of Gene Therapy. 18: 188-97. PMID 19755960 DOI: 10.1038/Mt.2009.219  1
2010 Semenza GL. Vascular responses to hypoxia and ischemia. Arteriosclerosis, Thrombosis, and Vascular Biology. 30: 648-52. PMID 19729615 DOI: 10.1161/Atvbaha.108.181644  0.01
2010 Le A, Cooper CR, Gouw A, Maitra A, Dinavahi R, Deck L, Royer R, Jagt DV, Semenza G, Dang CV. Abstract 5453: Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression Cancer Research. 70: 5453-5453. DOI: 10.1158/1538-7445.Am10-5453  1
2010 Sarkar K, Fox-Talbot K, Steenbergen C, Bosch-Marcé M, Semenza GL. Adenoviral transfer of HIF-1α enhances vascular responses to critical limb ischemia in diabetic mice (Proceedings of the National Academy Sciences of United States of America (2009) 106, 44 (18769-18774) DOI: 10.1073/pnas. 0910561106) Proceedings of the National Academy of Sciences of the United States of America. 107. DOI: 10.1073/Pnas.0913116107  1
2009 Rey S, Lee K, Wang CJ, Gupta K, Chen S, McMillan A, Bhise N, Levchenko A, Semenza GL. Synergistic effect of HIF-1alpha gene therapy and HIF-1-activated bone marrow-derived angiogenic cells in a mouse model of limb ischemia. Proceedings of the National Academy of Sciences of the United States of America. 106: 20399-404. PMID 19948968 DOI: 10.1073/Pnas.0911921106  1
2009 Semenza GL. Regulation of vascularization by hypoxia-inducible factor 1. Annals of the New York Academy of Sciences. 1177: 2-8. PMID 19845601 DOI: 10.1111/J.1749-6632.2009.05032.X  0.01
2009 Sarkar K, Fox-Talbot K, Steenbergen C, Bosch-Marcé M, Semenza GL. Adenoviral transfer of HIF-1alpha enhances vascular responses to critical limb ischemia in diabetic mice. Proceedings of the National Academy of Sciences of the United States of America. 106: 18769-74. PMID 19841279 DOI: 10.1073/Pnas.0910561106  1
2009 Lee K, Zhang H, Qian DZ, Rey S, Liu JO, Semenza GL. Acriflavine inhibits HIF-1 dimerization, tumor growth, and vascularization. Proceedings of the National Academy of Sciences of the United States of America. 106: 17910-5. PMID 19805192 DOI: 10.1073/Pnas.0909353106  1
2009 Wikenheiser J, Wolfram JA, Gargesha M, Yang K, Karunamuni G, Wilson DL, Semenza GL, Agani F, Fisher SA, Ward N, Watanabe M. Altered hypoxia-inducible factor-1 alpha expression levels correlate with coronary vessel anomalies. Developmental Dynamics : An Official Publication of the American Association of Anatomists. 238: 2688-700. PMID 19777592 DOI: 10.1002/Dvdy.22089  1
2009 Siddiq A, Aminova LR, Troy CM, Suh K, Messer Z, Semenza GL, Ratan RR. Selective inhibition of hypoxia-inducible factor (HIF) prolyl-hydroxylase 1 mediates neuroprotection against normoxic oxidative death via HIF- and CREB-independent pathways. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 8828-38. PMID 19587290 DOI: 10.1523/Jneurosci.1779-09.2009  1
2009 Schipani E, Maes C, Carmeliet G, Semenza GL. Regulation of osteogenesis-angiogenesis coupling by HIFs and VEGF. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. 24: 1347-53. PMID 19558314 DOI: 10.1359/Jbmr.090602  1
2009 Xia M, Huang R, Sun Y, Semenza GL, Aldred SF, Witt KL, Inglese J, Tice RR, Austin CP. Identification of chemical compounds that induce HIF-1alpha activity. Toxicological Sciences : An Official Journal of the Society of Toxicology. 112: 153-63. PMID 19502547 DOI: 10.1093/Toxsci/Kfp123  1
2009 Semenza GL. Involvement of oxygen-sensing pathways in physiologic and pathologic erythropoiesis. Blood. 114: 2015-9. PMID 19494350 DOI: 10.1182/Blood-2009-05-189985  0.01
2009 Kizaka-Kondoh S, Itasaka S, Zeng L, Tanaka S, Zhao T, Takahashi Y, Shibuya K, Hirota K, Semenza GL, Hiraoka M. Selective killing of hypoxia-inducible factor-1-active cells improves survival in a mouse model of invasive and metastatic pancreatic cancer. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 15: 3433-41. PMID 19417024 DOI: 10.1158/1078-0432.Ccr-08-2267  0.01
2009 Lee K, Qian DZ, Rey S, Wei H, Liu JO, Semenza GL. Anthracycline chemotherapy inhibits HIF-1 transcriptional activity and tumor-induced mobilization of circulating angiogenic cells. Proceedings of the National Academy of Sciences of the United States of America. 106: 2353-8. PMID 19168635 DOI: 10.1073/Pnas.0812801106  1
2009 Guo J, Lu W, Shimoda LA, Semenza GL, Georas SN. Enhanced interferon-gamma gene expression in T Cells and reduced ovalbumin-dependent lung eosinophilia in hypoxia-inducible factor-1-alpha-deficient mice. International Archives of Allergy and Immunology. 149: 98-102. PMID 19127065 DOI: 10.1159/000189191  1
2008 Ratan RR, Siddiq A, Aminova L, Langley B, McConoughey S, Karpisheva K, Lee HH, Carmichael T, Kornblum H, Coppola G, Geschwind DH, Hoke A, Smirnova N, Rink C, Roy S, ... ... Semenza GL, et al. Small molecule activation of adaptive gene expression: tilorone or its analogs are novel potent activators of hypoxia inducible factor-1 that provide prophylaxis against stroke and spinal cord injury. Annals of the New York Academy of Sciences. 1147: 383-94. PMID 19076458 DOI: 10.1196/Annals.1427.033  1
2008 Zhang H, Qian DZ, Tan YS, Lee K, Gao P, Ren YR, Rey S, Hammers H, Chang D, Pili R, Dang CV, Liu JO, Semenza GL. Digoxin and other cardiac glycosides inhibit HIF-1α synthesis and block tumor growth Proceedings of the National Academy of Sciences of the United States of America. 105: 19579-19586. PMID 19020076 DOI: 10.1073/Pnas.0809763105  1
2008 Nanduri J, Yuan G, Kumar GK, Semenza GL, Prabhakar NR. Transcriptional responses to intermittent hypoxia. Respiratory Physiology & Neurobiology. 164: 277-81. PMID 18692603 DOI: 10.1016/J.Resp.2008.07.006  1
2008 Yuan G, Nanduri J, Khan S, Semenza GL, Prabhakar NR. Induction of HIF-1alpha expression by intermittent hypoxia: involvement of NADPH oxidase, Ca2+ signaling, prolyl hydroxylases, and mTOR. Journal of Cellular Physiology. 217: 674-85. PMID 18651560 DOI: 10.1002/Jcp.21537  1
2008 Sullivan R, Paré GC, Frederiksen LJ, Semenza GL, Graham CH. Hypoxia-induced resistance to anticancer drugs is associated with decreased senescence and requires hypoxia-inducible factor-1 activity. Molecular Cancer Therapeutics. 7: 1961-73. PMID 18645006 DOI: 10.1158/1535-7163.Mct-08-0198  1
2008 Liu L, Marti GP, Wei X, Zhang X, Zhang H, Liu YV, Nastai M, Semenza GL, Harmon JW. Age-dependent impairment of HIF-1alpha expression in diabetic mice: Correction with electroporation-facilitated gene therapy increases wound healing, angiogenesis, and circulating angiogenic cells. Journal of Cellular Physiology. 217: 319-27. PMID 18506785 DOI: 10.1002/Jcp.21503  1
2008 Oda S, Oda T, Nishi K, Takabuchi S, Wakamatsu T, Tanaka T, Adachi T, Fukuda K, Semenza GL, Hirota K. Macrophage migration inhibitory factor activates hypoxia-inducible factor in a p53-dependent manner. Plos One. 3: e2215. PMID 18493321 DOI: 10.1371/Journal.Pone.0002215  0.01
2008 Zhang H, Bosch-Marce M, Shimoda LA, Tan YS, Baek JH, Wesley JB, Gonzalez FJ, Semenza GL. Mitochondrial autophagy is an HIF-1-dependent adaptive metabolic response to hypoxia. The Journal of Biological Chemistry. 283: 10892-903. PMID 18281291 DOI: 10.1074/Jbc.M800102200  1
2008 Nishi K, Oda T, Takabuchi S, Oda S, Fukuda K, Adachi T, Semenza GL, Shingu K, Hirota K. LPS induces hypoxia-inducible factor 1 activation in macrophage-differentiated cells in a reactive oxygen species-dependent manner. Antioxidants & Redox Signaling. 10: 983-95. PMID 18199003 DOI: 10.1089/Ars.2007.1825  0.01
2008 Whitman EM, Pisarcik S, Luke T, Fallon M, Wang J, Sylvester JT, Semenza GL, Shimoda LA. Endothelin-1 mediates hypoxia-induced inhibition of voltage-gated K+ channel expression in pulmonary arterial myocytes. American Journal of Physiology. Lung Cellular and Molecular Physiology. 294: L309-18. PMID 18065659 DOI: 10.1152/Ajplung.00091.2007  1
2008 Kimura M, Takabuchi S, Tanaka T, Murata M, Nishi K, Oda S, Oda T, Kanai M, Fukuda K, Kizaka-Kondoh S, Adachi T, Takabayashi A, Semenza GL, Hirota K. n-Propyl gallate activates hypoxia-inducible factor 1 by modulating intracellular oxygen-sensing systems. The Biochemical Journal. 411: 97-105. PMID 18047470 DOI: 10.1042/Bj20070824  0.01
2008 Cai Z, Zhong H, Bosch-Marce M, Fox-Talbot K, Wang L, Wei C, Trush MA, Semenza GL. Complete loss of ischaemic preconditioning-induced cardioprotection in mice with partial deficiency of HIF-1 alpha. Cardiovascular Research. 77: 463-70. PMID 18006459 DOI: 10.1093/Cvr/Cvm035  1
2007 Semenza GL. Hypoxia and human disease-and the Journal of Molecular Medicine. Journal of Molecular Medicine (Berlin, Germany). 85: 1293-4. PMID 18026915 DOI: 10.1007/S00109-007-0285-Z  0.01
2007 Liu YV, Hubbi ME, Pan F, McDonald KR, Mansharamani M, Cole RN, Liu JO, Semenza GL. Calcineurin promotes hypoxia-inducible factor 1alpha expression by dephosphorylating RACK1 and blocking RACK1 dimerization. The Journal of Biological Chemistry. 282: 37064-73. PMID 17965024 DOI: 10.1074/Jbc.M705015200  1
2007 Bosch-Marce M, Okuyama H, Wesley JB, Sarkar K, Kimura H, Liu YV, Zhang H, Strazza M, Rey S, Savino L, Zhou YF, McDonald KR, Na Y, Vandiver S, Rabi A, ... ... Semenza GL, et al. Effects of aging and hypoxia-inducible factor-1 activity on angiogenic cell mobilization and recovery of perfusion after limb ischemia. Circulation Research. 101: 1310-8. PMID 17932327 DOI: 10.1161/Circresaha.107.153346  1
2007 Semenza GL. Hypoxia-inducible factor 1 (HIF-1) pathway. Science's Stke : Signal Transduction Knowledge Environment. 2007: cm8. PMID 17925579 DOI: 10.1126/Stke.4072007Cm8  0.01
2007 Baek JH, Liu YV, McDonald KR, Wesley JB, Zhang H, Semenza GL. Spermidine/spermine N(1)-acetyltransferase-1 binds to hypoxia-inducible factor-1alpha (HIF-1alpha) and RACK1 and promotes ubiquitination and degradation of HIF-1alpha. The Journal of Biological Chemistry. 282: 33358-66. PMID 17875644 DOI: 10.1074/Jbc.M705627200  1
2007 Kim JW, Gao P, Liu YC, Semenza GL, Dang CV. Hypoxia-inducible factor 1 and dysregulated c-Myc cooperatively induce vascular endothelial growth factor and metabolic switches hexokinase 2 and pyruvate dehydrogenase kinase 1 Molecular and Cellular Biology. 27: 7381-7393. PMID 17785433 DOI: 10.1128/Mcb.00440-07  1
2007 Gao P, Zhang H, Dinavahi R, Li F, Xiang Y, Raman V, Bhujwalla ZM, Felsher DW, Cheng L, Pevsner J, Lee LA, Semenza GL, Dang CV. HIF-dependent antitumorigenic effect of antioxidants in vivo. Cancer Cell. 12: 230-8. PMID 17785204 DOI: 10.1016/J.Ccr.2007.08.004  1
2007 Semenza GL. Regulation of tissue perfusion in mammals by hypoxia-inducible factor 1. Experimental Physiology. 92: 988-91. PMID 17720748 DOI: 10.1113/Expphysiol.2006.036343  0.01
2007 Semenza GL, Prabhakar NR. HIF-1-dependent respiratory, cardiovascular, and redox responses to chronic intermittent hypoxia. Antioxidants & Redox Signaling. 9: 1391-6. PMID 17627473 DOI: 10.1089/Ars.2007.1691  1
2007 Prabhakar NR, Kumar GK, Nanduri J, Semenza GL. ROS signaling in systemic and cellular responses to chronic intermittent hypoxia. Antioxidants & Redox Signaling. 9: 1397-403. PMID 17627465 DOI: 10.1089/Ars.2007.1732  1
2007 Tomita M, Semenza GL, Michiels C, Matsuda T, Uchihara JN, Okudaira T, Tanaka Y, Taira N, Ohshiro K, Mori N. Activation of hypoxia-inducible factor 1 in human T-cell leukaemia virus type 1-infected cell lines and primary adult T-cell leukaemia cells. The Biochemical Journal. 406: 317-23. PMID 17576198 DOI: 10.1042/Bj20070286  0.01
2007 Baek JH, Liu YV, McDonald KR, Wesley JB, Hubbi ME, Byun H, Semenza GL. Spermidine/spermine-N1-acetyltransferase 2 is an essential component of the ubiquitin ligase complex that regulates hypoxia-inducible factor 1alpha. The Journal of Biological Chemistry. 282: 23572-80. PMID 17558023 DOI: 10.1074/Jbc.M703504200  1
2007 Zhang H, Gao P, Fukuda R, Kumar G, Krishnamachary B, Zeller KI, Dang CV, Semenza GL. HIF-1 inhibits mitochondrial biogenesis and cellular respiration in VHL-deficient renal cell carcinoma by repression of C-MYC activity. Cancer Cell. 11: 407-20. PMID 17482131 DOI: 10.1016/J.Ccr.2007.04.001  1
2007 Fukuda R, Zhang H, Kim Jw, Shimoda L, Dang CV, Semenza G. HIF-1 Regulates Cytochrome Oxidase Subunits to Optimize Efficiency of Respiration in Hypoxic Cells Cell. 129: 111-122. PMID 17418790 DOI: 10.1016/J.Cell.2007.01.047  1
2007 Liu YV, Semenza GL. RACK1 vs. HSP90: competition for HIF-1 alpha degradation vs. stabilization. Cell Cycle (Georgetown, Tex.). 6: 656-9. PMID 17361105 DOI: 10.4161/cc.6.6.3981  1
2007 Liu YV, Baek JH, Zhang H, Diez R, Cole RN, Semenza GL. RACK1 competes with HSP90 for binding to HIF-1alpha and is required for O(2)-independent and HSP90 inhibitor-induced degradation of HIF-1alpha. Molecular Cell. 25: 207-17. PMID 17244529 DOI: 10.1016/J.Molcel.2007.01.001  1
2007 Komatsu DE, Bosch-Marce M, Semenza GL, Hadjiargyrou M. Enhanced bone regeneration associated with decreased apoptosis in mice with partial HIF-1alpha deficiency. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. 22: 366-74. PMID 17181398 DOI: 10.1359/Jbmr.061207  1
2007 Xu B, Doughman Y, Turakhia M, Jiang W, Landsettle CE, Agani FH, Semenza GL, Watanabe M, Yang YC. Partial rescue of defects in Cited2-deficient embryos by HIF-1alpha heterozygosity. Developmental Biology. 301: 130-40. PMID 17022961 DOI: 10.1016/J.Ydbio.2006.08.072  0.01
2006 Tatum JL, Kelloff GJ, Gillies RJ, Arbeit JM, Brown JM, Chao KS, Chapman JD, Eckelman WC, Fyles AW, Giaccia AJ, Hill RP, Koch CJ, Krishna MC, Krohn KA, Lewis JS, ... ... Semenza GL, et al. Hypoxia: importance in tumor biology, noninvasive measurement by imaging, and value of its measurement in the management of cancer therapy. International Journal of Radiation Biology. 82: 699-757. PMID 17118889 DOI: 10.1080/09553000601002324  1
2006 Zhou YF, Bosch-Marce M, Okuyama H, Krishnamachary B, Kimura H, Zhang L, Huso DL, Semenza GL. Spontaneous transformation of cultured mouse bone marrow-derived stromal cells. Cancer Research. 66: 10849-54. PMID 17108121 DOI: 10.1158/0008-5472.Can-06-2146  1
2006 Cai Z, Semenza GL. Is 15-min ischemia too lethal to be an ischemic preconditioning stimulus? Circulation Research. 99: e86. PMID 17095727 DOI: 10.1161/01.Res.0000249066.23049.70  1
2006 Peng YJ, Yuan G, Ramakrishnan D, Sharma SD, Bosch-Marce M, Kumar GK, Semenza GL, Prabhakar NR. Heterozygous HIF-1alpha deficiency impairs carotid body-mediated systemic responses and reactive oxygen species generation in mice exposed to intermittent hypoxia. The Journal of Physiology. 577: 705-16. PMID 16973705 DOI: 10.1113/Jphysiol.2006.114033  1
2006 Yoon D, Pastore YD, Divoky V, Liu E, Mlodnicka AE, Rainey K, Ponka P, Semenza GL, Schumacher A, Prchal JT. Hypoxia-inducible factor-1 deficiency results in dysregulated erythropoiesis signaling and iron homeostasis in mouse development. The Journal of Biological Chemistry. 281: 25703-11. PMID 16787915 DOI: 10.1074/Jbc.M602329200  1
2006 Hirota K, Semenza GL. Regulation of angiogenesis by hypoxia-inducible factor 1. Critical Reviews in Oncology/Hematology. 59: 15-26. PMID 16716598 DOI: 10.1016/J.Critrevonc.2005.12.003  0.04
2006 Wang J, Weigand L, Lu W, Sylvester JT, Semenza GL, Shimoda LA. Hypoxia inducible factor 1 mediates hypoxia-induced TRPC expression and elevated intracellular Ca2+ in pulmonary arterial smooth muscle cells. Circulation Research. 98: 1528-37. PMID 16709899 DOI: 10.1161/01.Res.0000227551.68124.98  1
2006 Semenza GL, Shimoda LA, Prabhakar NR. Regulation of gene expression by HIF-1. Novartis Foundation Symposium. 272: 2-8; discussion 8-14. PMID 16686426 DOI: 10.1002/9780470035009.Ch2  1
2006 Okuyama H, Krishnamachary B, Zhou YF, Nagasawa H, Bosch-Marce M, Semenza GL. Expression of vascular endothelial growth factor receptor 1 in bone marrow-derived mesenchymal cells is dependent on hypoxia-inducible factor 1. The Journal of Biological Chemistry. 281: 15554-63. PMID 16574650 DOI: 10.1074/Jbc.M602003200  1
2006 Kim JW, Tchernyshyov I, Semenza GL, Dang CV. HIF-1-mediated expression of pyruvate dehydrogenase kinase: A metabolic switch required for cellular adaptation to hypoxia Cell Metabolism. 3: 177-185. PMID 16517405 DOI: 10.1016/J.Cmet.2006.02.002  1
2006 Krishnamachary B, Zagzag D, Nagasawa H, Rainey K, Okuyama H, Baek JH, Semenza GL. Hypoxia-inducible factor-1-dependent repression of E-cadherin in von Hippel-Lindau tumor suppressor-null renal cell carcinoma mediated by TCF3, ZFHX1A, and ZFHX1B. Cancer Research. 66: 2725-31. PMID 16510593 DOI: 10.1158/0008-5472.Can-05-3719  1
2006 Li J, Bosch-Marce M, Nanayakkara A, Savransky V, Fried SK, Semenza GL, Polotsky VY. Altered metabolic responses to intermittent hypoxia in mice with partial deficiency of hypoxia-inducible factor-1alpha. Physiological Genomics. 25: 450-7. PMID 16507783 DOI: 10.1152/Physiolgenomics.00293.2005  1
2006 Oda T, Hirota K, Nishi K, Takabuchi S, Oda S, Yamada H, Arai T, Fukuda K, Kita T, Adachi T, Semenza GL, Nohara R. Activation of hypoxia-inducible factor 1 during macrophage differentiation. American Journal of Physiology. Cell Physiology. 291: C104-13. PMID 16481368 DOI: 10.1152/Ajpcell.00614.2005  0.01
2006 Campochiaro PA, Alani R, Alitalo K, Brooks P, Caldwell R, Carmeliet P, Claudio PP, D'Amato R, Das A, De Martin R, Detmar M, Ferrara N, Frank RN, Fruttiger M, Giordano A, ... ... Semenza G, et al. Ocular versus extraocular neovascularization: Mirror images or vague resemblances Investigative Ophthalmology and Visual Science. 47: 462-474. PMID 16431938 DOI: 10.1167/Iovs.05-1494  1
2006 Lahiri S, Roy A, Baby SM, Hoshi T, Semenza GL, Prabhakar NR. Oxygen sensing in the body. Progress in Biophysics and Molecular Biology. 91: 249-86. PMID 16137743 DOI: 10.1016/J.Pbiomolbio.2005.07.001  1
2005 Cai Z, Semenza GL. PTEN activity is modulated during ischemia and reperfusion: involvement in the induction and decay of preconditioning. Circulation Research. 97: 1351-9. PMID 16284183 DOI: 10.1161/01.Res.0000195656.52760.30  1
2005 Semenza GL. Pulmonary vascular responses to chronic hypoxia mediated by hypoxia-inducible factor 1. Proceedings of the American Thoracic Society. 2: 68-70. PMID 16113471 DOI: 10.1513/pats.200404-029MS  0.01
2005 Maloyan A, Eli-Berchoer L, Semenza GL, Gerstenblith G, Stern MD, Horowitz M. HIF-1alpha-targeted pathways are activated by heat acclimation and contribute to acclimation-ischemic cross-tolerance in the heart. Physiological Genomics. 23: 79-88. PMID 16046617 DOI: 10.1152/Physiolgenomics.00279.2004  1
2005 Zagzag D, Krishnamachary B, Yee H, Okuyama H, Chiriboga L, Ali MA, Melamed J, Semenza GL. Stromal cell-derived factor-1alpha and CXCR4 expression in hemangioblastoma and clear cell-renal cell carcinoma: von Hippel-Lindau loss-of-function induces expression of a ligand and its receptor. Cancer Research. 65: 6178-88. PMID 16024619 DOI: 10.1158/0008-5472.Can-04-4406  1
2005 Xu Q, Briggs J, Park S, Niu G, Kortylewski M, Zhang S, Gritsko T, Turkson J, Kay H, Semenza GL, Cheng JQ, Jove R, Yu H. Targeting Stat3 blocks both HIF-1 and VEGF expression induced by multiple oncogenic growth signaling pathways Oncogene. 24: 5552-5560. PMID 16007214 DOI: 10.1038/Sj.Onc.1208719  0.2
2005 Patel TH, Kimura H, Weiss CR, Semenza GL, Hofmann LV. Constitutively active HIF-1alpha improves perfusion and arterial remodeling in an endovascular model of limb ischemia. Cardiovascular Research. 68: 144-54. PMID 15921668 DOI: 10.1016/J.Cardiores.2005.05.002  0.01
2005 Gray MJ, Zhang J, Ellis LM, Semenza GL, Evans DB, Watowich SS, Gallick GE. HIF-1alpha, STAT3, CBP/p300 and Ref-1/APE are components of a transcriptional complex that regulates Src-dependent hypoxia-induced expression of VEGF in pancreatic and prostate carcinomas. Oncogene. 24: 3110-20. PMID 15735682 DOI: 10.1038/Sj.Onc.1208513  1
2005 Baek JH, Mahon PC, Oh J, Kelly B, Krishnamachary B, Pearson M, Chan DA, Giaccia AJ, Semenza GL. OS-9 interacts with hypoxia-inducible factor 1alpha and prolyl hydroxylases to promote oxygen-dependent degradation of HIF-1alpha. Molecular Cell. 17: 503-12. PMID 15721254 DOI: 10.1016/J.Molcel.2005.01.011  1
2005 Yuan G, Nanduri J, Bhasker CR, Semenza GL, Prabhakar NR. Ca2+/calmodulin kinase-dependent activation of hypoxia inducible factor 1 transcriptional activity in cells subjected to intermittent hypoxia. The Journal of Biological Chemistry. 280: 4321-8. PMID 15569687 DOI: 10.1074/Jbc.M407706200  1
2005 Manalo DJ, Rowan A, Lavoie T, Natarajan L, Kelly BD, Ye SQ, Garcia JG, Semenza GL. Transcriptional regulation of vascular endothelial cell responses to hypoxia by HIF-1. Blood. 105: 659-69. PMID 15374877 DOI: 10.1182/Blood-2004-07-2958  1
2005 Dang CV, Semenza GL. Cancer energy metabolism Drug Discovery Today: Disease Mechanisms. 2. DOI: 10.1016/J.Ddmec.2005.05.039  1
2004 Takabuchi S, Hirota K, Nishi K, Oda S, Oda T, Shingu K, Takabayashi A, Adachi T, Semenza GL, Fukuda K. The intravenous anesthetic propofol inhibits hypoxia-inducible factor 1 activity in an oxygen tension-dependent manner. Febs Letters. 577: 434-8. PMID 15556623 DOI: 10.1016/J.Febslet.2004.10.042  0.01
2004 Takabuchi S, Hirota K, Nishi K, Oda S, Oda T, Shingu K, Takabayashi A, Adachi T, Semenza GL, Fukuda K. The inhibitory effect of sodium nitroprusside on HIF-1 activation is not dependent on nitric oxide-soluble guanylyl cyclase pathway. Biochemical and Biophysical Research Communications. 324: 417-23. PMID 15465035 DOI: 10.1016/J.Bbrc.2004.09.064  0.01
2004 Hirota K, Fukuda R, Takabuchi S, Kizaka-Kondoh S, Adachi T, Fukuda K, Semenza GL. Induction of hypoxia-inducible factor 1 activity by muscarinic acetylcholine receptor signaling. The Journal of Biological Chemistry. 279: 41521-8. PMID 15280370 DOI: 10.1074/Jbc.M405164200  1
2004 Stoeltzing O, McCarty MF, Wey JS, Fan F, Liu W, Belcheva A, Bucana CD, Semenza GL, Ellis LM. Role of hypoxia-inducible factor 1alpha in gastric cancer cell growth, angiogenesis, and vessel maturation. Journal of the National Cancer Institute. 96: 946-56. PMID 15199114 DOI: 10.1093/Jnci/Djh168  1
2004 Kaufman B, Scharf O, Arbeit J, Ashcroft M, Brown JM, Bruick RK, Chapman JD, Evans SM, Giaccia AJ, Harris AL, Huang E, Johnson R, Kaelin W, Koch CJ, Maxwell P, ... ... Semenza GL, et al. Proceedings of the Oxygen Homeostasis/Hypoxia Meeting. Cancer Research. 64: 3350-6. PMID 15126380 DOI: 10.1158/0008-5472.Can-03-2611  1
2004 Cai Z, Semenza GL. Phosphatidylinositol-3-kinase signaling is required for erythropoietin-mediated acute protection against myocardial ischemia/reperfusion injury. Circulation. 109: 2050-3. PMID 15117842 DOI: 10.1161/01.Cir.0000127954.98131.23  1
2004 Zhong H, Semenza GL, Simons JW, De Marzo AM. Up-regulation of hypoxia-inducible factor 1alpha is an early event in prostate carcinogenesis. Cancer Detection and Prevention. 28: 88-93. PMID 15068831 DOI: 10.1016/J.Cdp.2003.12.009  1
2004 Kasuno K, Takabuchi S, Fukuda K, Kizaka-Kondoh S, Yodoi J, Adachi T, Semenza GL, Hirota K. Nitric oxide induces hypoxia-inducible factor 1 activation that is dependent on MAPK and phosphatidylinositol 3-kinase signaling. The Journal of Biological Chemistry. 279: 2550-8. PMID 14600153 DOI: 10.1074/jbc.M308197200  0.01
2004 Stoeltzing O, McCarty MF, Wey J, Fan F, Liu W, Bucana CD, Mansfield P, Semenza GL, Ellis LM. Inhibition of HIF-1α reduces tumor growth and angiogenesis of human gastric cancer Annals of Surgical Oncology. 11. DOI: 10.1007/Bf02524012  1
2003 Kelly BD, Hackett SF, Hirota K, Oshima Y, Cai Z, Berg-Dixon S, Rowan A, Yan Z, Campochiaro PA, Semenza GL. Cell type-specific regulation of angiogenic growth factor gene expression and induction of angiogenesis in nonischemic tissue by a constitutively active form of hypoxia-inducible factor 1. Circulation Research. 93: 1074-81. PMID 14576200 DOI: 10.1161/01.Res.0000102937.50486.1B  1
2003 Stoeltzing O, Liu W, Reinmuth N, Fan F, Parikh AA, Bucana CD, Evans DB, Semenza GL, Ellis LM. Regulation of hypoxia-inducible factor-1alpha, vascular endothelial growth factor, and angiogenesis by an insulin-like growth factor-I receptor autocrine loop in human pancreatic cancer. The American Journal of Pathology. 163: 1001-11. PMID 12937141 DOI: 10.1016/S0002-9440(10)63460-8  1
2003 Cai Z, Manalo DJ, Wei G, Rodriguez ER, Fox-Talbot K, Lu H, Zweier JL, Semenza GL. Hearts from rodents exposed to intermittent hypoxia or erythropoietin are protected against ischemia-reperfusion injury. Circulation. 108: 79-85. PMID 12796124 DOI: 10.1161/01.Cir.0000078635.89229.8A  1
2002 Ang SO, Chen H, Hirota K, Gordeuk VR, Jelinek J, Guan Y, Liu E, Sergueeva AI, Miasnikova GY, Mole D, Maxwell PH, Stockton DW, Semenza GL, Prchal JT. Disruption of oxygen homeostasis underlies congenital Chuvash polycythemia Nature Genetics. 32: 614-621. PMID 12415268 DOI: 10.1038/Ng1019  1
2002 Cargile CB, Goh DL, Goodman BK, Chen XN, Korenberg JR, Semenza GL, Thomas GH. Molecular cytogenetic characterization of a subtle interstitial del(3)(p25.3p26.2) in a patient with deletion 3p syndrome. American Journal of Medical Genetics. 109: 133-8. PMID 11977162 DOI: 10.1002/Ajmg.10323  1
2002 Kojima H, Gu H, Nomura S, Caldwell CC, Kobata T, Carmeliet P, Semenza GL, Sitkovsky MV. Abnormal B lymphocyte development and autoimmunity in hypoxia-inducible factor 1alpha -deficient chimeric mice. Proceedings of the National Academy of Sciences of the United States of America. 99: 2170-4. PMID 11854513 DOI: 10.1073/Pnas.052706699  0.04
2002 Kline DD, Peng YJ, Manalo DJ, Semenza GL, Prabhakar NR. Defective carotid body function and impaired ventilatory responses to chronic hypoxia in mice partially deficient for hypoxia-inducible factor 1 alpha. Proceedings of the National Academy of Sciences of the United States of America. 99: 821-6. PMID 11792862 DOI: 10.1073/Pnas.022634199  1
2001 Semenza GL, Artemov D, Bedi A, Bhujwalla Z, Chiles K, Feldser D, Laughner E, Ravi R, Simons J, Taghavi P, Zhong H. 'The metabolism of tumours': 70 years later Novartis Foundation Symposium. 240: 251-260. PMID 11727934 DOI: 10.1002/0470868716.Ch17  1
2001 Tuder RM, Chacon M, Alger L, Wang J, Taraseviciene-Stewart L, Kasahara Y, Cool CD, Bishop AE, Geraci M, Semenza GL, Yacoub M, Polak JM, Voelkel NF. Expression of angiogenesis-related molecules in plexiform lesions in severe pulmonary hypertension: evidence for a process of disordered angiogenesis. The Journal of Pathology. 195: 367-74. PMID 11673836 DOI: 10.1002/Path.953  1
2001 Dong Z, Venkatachalam MA, Wang J, Patel Y, Saikumar P, Semenza GL, Force T, Nishiyama J. Up-regulation of apoptosis inhibitory protein IAP-2 by hypoxia. Hif-1-independent mechanisms. The Journal of Biological Chemistry. 276: 18702-9. PMID 11278985 DOI: 10.1074/Jbc.M011774200  1
2001 Bos R, Zhong H, Hanrahan CF, Mommers EC, Semenza GL, Pinedo HM, Abeloff MD, Simons JW, van Diest PJ, van der Wall E. Levels of hypoxia-inducible factor-1 alpha during breast carcinogenesis. Journal of the National Cancer Institute. 93: 309-14. PMID 11181778 DOI: 10.1093/Jnci/93.4.309  1
2001 Gardner LB, Li Q, Park MS, Flanagan WM, Semenza GL, Dang CV. Hypoxia Inhibits G1/S Transition through Regulation of p27 Expression Journal of Biological Chemistry. 276: 7919-7926. PMID 11112789 DOI: 10.1074/Jbc.M010189200  1
2000 Zagzag D, Friedlander DR, Margolis B, Grumet M, Semenza GL, Zhong H, Simons JW, Holash J, Wiegand SJ, Yancopoulos GD. Molecular events implicated in brain tumor angiogenesis and invasion. Pediatric Neurosurgery. 33: 49-55. PMID 11025423 DOI: 10.1159/000028975  1
2000 Bergeron M, Gidday JM, Yu AY, Semenza GL, Ferriero DM, Sharp FR. Role of hypoxia-inducible factor-1 in hypoxia-induced ischemic tolerance in neonatal rat brain. Annals of Neurology. 48: 285-96. PMID 10976634 DOI: 10.1002/1531-8249(200009)48:3<285::Aid-Ana2>3.0.Co;2-8  1
2000 Semenza GL. Series Introduction: Tissue ischemia: pathophysiology and therapeutics Journal of Clinical Investigation. 106: 613-614. PMID 10974010 DOI: 10.1172/Jci10913  0.01
2000 Zagzag D, Zhong H, Scalzitti JM, Laughner E, Simons JW, Semenza GL. Expression of hypoxia-inducible factor 1alpha in brain tumors: association with angiogenesis, invasion, and progression. Cancer. 88: 2606-18. PMID 10861440 DOI: 10.1002/1097-0142(20000601)88:11<2606::AID-CNCR25>3.0.CO;2-W  1
2000 Semenza GL, Agani F, Feldser D, Iyer N, Kotch L, Laughner E, Yu A. Hypoxia, HIF-1, and the pathophysiology of common human diseases Advances in Experimental Medicine and Biology. 475: 123-130. PMID 10849654  1
2000 Semenza GL. HIF-1 and human disease: one highly involved factor Genes & Development. 14: 1983-1991. DOI: 10.1101/Gad.14.16.1983  0.01
2000 Ravi R, Mookerjee B, Bhujwalla ZM, Sutter CH, Artemov D, Zeng Q, Dillehay LE, Madan A, Semenza GL, Bedi A. Regulation of tumor angiogenesis by p53-induced degradation of hypoxia-inducible factor 1α Genes & Development. 14: 34-44. DOI: 10.1101/Gad.14.1.34  1
1999 Bergeron M, Yu AY, Solway KE, Semenza GL, Sharp FR. Induction of hypoxia-inducible factor-1 (HIF-1) and its target genes following focal ischaemia in rat brain. The European Journal of Neuroscience. 11: 4159-70. PMID 10594641 DOI: 10.1046/J.1460-9568.1999.00845.X  1
1999 Zaman K, Ryu H, Hall D, O'Donovan K, Lin KI, Miller MP, Marquis JC, Baraban JM, Semenza GL, Ratan RR. Protection from oxidative stress-induced apoptosis in cortical neuronal cultures by iron chelators is associated with enhanced DNA binding of hypoxia-inducible factor-1 and ATF-1/CREB and increased expression of glycolytic enzymes, p21(waf1/cip1), and erythropoietin. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 19: 9821-30. PMID 10559391 DOI: 10.1523/Jneurosci.19-22-09821.1999  1
1999 Dang CV, Semenza GL. Oncogenic alterations of metabolism Trends in Biochemical Sciences. 24: 68-72. PMID 10098401 DOI: 10.1016/S0968-0004(98)01344-9  1
1999 Yu AY, Shimoda LA, Iyer NV, Huso DL, Sun X, McWilliams R, Beaty T, Sham JS, Wiener CM, Sylvester JT, Semenza GL. Impaired physiological responses to chronic hypoxia in mice partially deficient for hypoxia-inducible factor 1alpha. The Journal of Clinical Investigation. 103: 691-6. PMID 10074486 DOI: 10.1172/Jci5912  1
1998 Palmer LA, Semenza GL, Stoler MH, Johns RA. Hypoxia induces type II NOS gene expression in pulmonary artery endothelial cells via HIF-1. American Journal of Physiology. Lung Cellular and Molecular Physiology. 274: L212-L219. PMID 29585685 DOI: 10.1152/ajplung.1998.274.2.L212  1
1998 Yu AY, Frid MG, Shimoda LA, Wiener CM, Stenmark K, Semenza GL. Temporal, spatial, and oxygen-regulated expression of hypoxia-inducible factor-1 in the lung. American Journal of Physiology. Lung Cellular and Molecular Physiology. 275: L818-L826. PMID 29585640 DOI: 10.1152/ajplung.1998.275.4.L818  1
1998 Iyer NV, Leung SW, Semenza GL. The human hypoxia-inducible factor 1α gene: HIF1A structure and evolutionary conservation Genomics. 52: 159-165. PMID 9782081 DOI: 10.1006/Geno.1998.5416  1
1998 Yu AY, Frid MG, Shimoda LA, Wiener CM, Stenmark K, Semenza GL. Temporal, spatial, and oxygen-regulated expression of hypoxia-inducible factor-1 in the lung. The American Journal of Physiology. 275: L818-26. PMID 9755115 DOI: 10.1152/Ajplung.1998.275.4.L818  1
1998 Palmer LA, Semenza GL, Stoler MH, Johns RA. Hypoxia induces type II NOS gene expression in pulmonary artery endothelial cells via HIF-1. The American Journal of Physiology. 274: L212-9. PMID 9486205 DOI: 10.1152/Ajplung.1998.274.2.L212  1
1998 Iyer NV, Kotch LE, Agani F, Leung SW, Laughner E, Wenger RH, Gassmann M, Gearhart JD, Lawler AM, Yu AY, Semenza GL. Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1 alpha. Genes & Development. 12: 149-62. PMID 9436976 DOI: 10.1101/Gad.12.2.149  1
1998 Semenza GL, Agani F, Iyer N, Jiang B, Laughner E, Leung S, Roe R, Wiener C, Yu A. Transcriptional Responses Mediated by Hypoxia-Inducible Factor 1 The Keio Journal of Medicine. 45: 421-427. DOI: 10.1007/978-4-431-68476-3_52  1
1997 Winograd J, Reilly MP, Roe R, Lutz J, Laughner E, Xu X, Hu L, Asakura T, vander Kolk C, Strandberg JD, Semenza GL. Perinatal lethality and multiple craniofacial malformations in MSX2 transgenic mice. Human Molecular Genetics. 6: 369-79. PMID 9147639 DOI: 10.1093/Hmg/6.3.369  1
1997 Lee PJ, Jiang BH, Chin BY, Iyer NV, Alam J, Semenza GL, Choi AMK. Hypoxia-inducible factor-1 mediates transcriptional activation of the heme oxygenase-1 gene in response to hypoxia Journal of Biological Chemistry. 272: 5375-5381. PMID 9038135 DOI: 10.1074/Jbc.272.9.5375  1
1995 Semenza GL, Wang GL, Kundu R. DNA Binding and Transcriptional Properties of Wild-Type and Mutant Forms of the Homeodomain Protein Msx2 Biochemical and Biophysical Research Communications. 209: 257-262. PMID 7726844 DOI: 10.1006/Bbrc.1995.1497  1
1993 Koury ST, Bondurant MC, Semenza GL, Koury MJ. The use of in situ hybridization to study erythropoietin gene expression in murine kidney and liver Microscopy Research and Technique. 25: 29-39. PMID 8353306 DOI: 10.1002/Jemt.1070250106  1
1989 Semenza GL, Dowling CE, Kazazian HH. Hinf I polymorphism 3' to the human beta-globin gene detected by the polymerase chain reaction (PCR). Nucleic Acids Research. 17: 2376. PMID 2565032 DOI: 10.1093/Nar/17.6.2376  0.56
1984 Semenza GL, Malladi P, Surrey S, Delgrosso K, Poncz M, Schwartz E. Detection of a novel DNA polymorphism in the beta-globin gene cluster. The Journal of Biological Chemistry. 259: 6045-8. PMID 6327661  1
1984 Semenza GL, Delgrosso K, Poncz M, Malladi P, Schwartz E, Surrey S. The silent carrier allele: beta thalassemia without a mutation in the beta-globin gene or its immediate flanking regions. Cell. 39: 123-8. PMID 6091904 DOI: 10.1016/0092-8674(84)90197-1  1
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