Vijay K. Kuchroo - Publications

Affiliations: 
Harvard University, Cambridge, MA, United States 
Area:
Immunology, Cell Biology, Molecular Biology

71 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Singer M, Wang C, Cong L, Marjanovic ND, Kowalczyk MS, Zhang H, Nyman J, Sakuishi K, Kurtulus S, Gennert D, Xia J, Kwon JY, Nevin J, Herbst RH, Yanai I, ... ... Kuchroo VK, et al. A Distinct Gene Module for Dysfunction Uncoupled from Activation in Tumor-Infiltrating T Cells. Cell. 166: 1500-1511.e9. PMID 27610572 DOI: 10.1016/j.cell.2016.08.052  0.44
2016 Anderson AC, Joller N, Kuchroo VK. Lag-3, Tim-3, and TIGIT: Co-inhibitory Receptors with Specialized Functions in Immune Regulation. Immunity. 44: 989-1004. PMID 27192565 DOI: 10.1016/j.immuni.2016.05.001  0.44
2015 Wang C, Yosef N, Gaublomme J, Wu C, Lee Y, Clish CB, Kaminski J, Xiao S, Zu Horste GM, Pawlak M, Kishi Y, Joller N, Karwacz K, Zhu C, Ordovas-Montanes M, ... ... Kuchroo VK, et al. CD5L/AIM Regulates Lipid Biosynthesis and Restrains Th17 Cell Pathogenicity. Cell. PMID 26607793 DOI: 10.1016/j.cell.2015.10.068  0.44
2015 Lee Y, Mitsdoerffer M, Xiao S, Gu G, Sobel RA, Kuchroo VK. IL-21R signaling is critical for induction of spontaneous experimental autoimmune encephalomyelitis. The Journal of Clinical Investigation. PMID 26413871 DOI: 10.1172/JCI75933  0.44
2015 Peters A, Fowler KD, Chalmin F, Merkler D, Kuchroo VK, Pot C. IL-27 Induces Th17 Differentiation in the Absence of STAT1 Signaling. Journal of Immunology (Baltimore, Md. : 1950). 195: 4144-53. PMID 26408664 DOI: 10.4049/jimmunol.1302246  0.44
2015 Talbot S, Abdulnour RE, Burkett PR, Lee S, Cronin SJ, Pascal MA, Laedermann C, Foster SL, Tran JV, Lai N, Chiu IM, Ghasemlou N, DiBiase M, Roberson D, Von Hehn C, ... ... Kuchroo VK, et al. Silencing Nociceptor Neurons Reduces Allergic Airway Inflammation. Neuron. PMID 26119026 DOI: 10.1016/j.neuron.2015.06.007  0.44
2015 Anderson AC, Sullivan JM, Tan DJ, Lee DH, Kuchroo VK. A T cell extrinsic mechanism by which IL-2 dampens Th17 differentiation. Journal of Autoimmunity. 59: 38-42. PMID 25725581 DOI: 10.1016/j.jaut.2015.02.001  0.44
2015 Zhu C, Sakuishi K, Xiao S, Sun Z, Zaghouani S, Gu G, Wang C, Tan DJ, Wu C, Rangachari M, Pertel T, Jin HT, Ahmed R, Anderson AC, Kuchroo VK. An IL-27/NFIL3 signalling axis drives Tim-3 and IL-10 expression and T-cell dysfunction. Nature Communications. 6: 6072. PMID 25614966 DOI: 10.1038/ncomms7072  0.44
2015 Xiao S, Brooks CR, Sobel RA, Kuchroo VK. Tim-1 is essential for induction and maintenance of IL-10 in regulatory B cells and their regulation of tissue inflammation. Journal of Immunology (Baltimore, Md. : 1950). 194: 1602-8. PMID 25582854 DOI: 10.4049/jimmunol.1402632  0.44
2015 Krishnamoorthy N, Burkett PR, Dalli J, Abdulnour RE, Colas R, Ramon S, Phipps RP, Petasis NA, Kuchroo VK, Serhan CN, Levy BD. Cutting edge: maresin-1 engages regulatory T cells to limit type 2 innate lymphoid cell activation and promote resolution of lung inflammation. Journal of Immunology (Baltimore, Md. : 1950). 194: 863-7. PMID 25539814 DOI: 10.4049/jimmunol.1402534  0.44
2015 Peters A, Burkett PR, Sobel RA, Buckley CD, Watson SP, Bettelli E, Kuchroo VK. Podoplanin negatively regulates CD4+ effector T cell responses. The Journal of Clinical Investigation. 125: 129-40. PMID 25415436 DOI: 10.1172/JCI74685  0.44
2015 Farh KK, Marson A, Zhu J, Kleinewietfeld M, Housley WJ, Beik S, Shoresh N, Whitton H, Ryan RJ, Shishkin AA, Hatan M, Carrasco-Alfonso MJ, Mayer D, Luckey CJ, Patsopoulos NA, ... ... Kuchroo VK, et al. Genetic and epigenetic fine mapping of causal autoimmune disease variants. Nature. 518: 337-43. PMID 25363779 DOI: 10.1038/nature13835  0.44
2015 Huang YH, Zhu C, Kondo Y, Anderson AC, Gandhi A, Russell A, Dougan SK, Petersen BS, Melum E, Pertel T, Clayton KL, Raab M, Chen Q, Beauchemin N, Yazaki PJ, ... ... Kuchroo VK, et al. CEACAM1 regulates TIM-3-mediated tolerance and exhaustion. Nature. 517: 386-90. PMID 25363763 DOI: 10.1038/nature13848  0.44
2014 Wu C, Thalhamer T, Franca RF, Xiao S, Wang C, Hotta C, Zhu C, Hirashima M, Anderson AC, Kuchroo VK. Galectin-9-CD44 interaction enhances stability and function of adaptive regulatory T cells. Immunity. 41: 270-82. PMID 25065622 DOI: 10.1016/j.immuni.2014.06.011  0.44
2014 Kuchroo VK, Anderson AC, Petrovas C. Coinhibitory receptors and CD8 T cell exhaustion in chronic infections. Current Opinion in Hiv and Aids. 9: 439-45. PMID 25010894 DOI: 10.1097/COH.0000000000000088  0.44
2014 Kuchroo VK, Anderson AC, Freeman GJ. Comment on "Tim-3 directly enhances CD8 T cell responses to acute Listeria monocytogenes infection". Journal of Immunology (Baltimore, Md. : 1950). 193: 467. PMID 24994907 DOI: 10.4049/jimmunol.1401123  0.44
2014 Thornley TB, Fang Z, Balasubramanian S, Larocca RA, Gong W, Gupta S, Csizmadia E, Degauque N, Kim BS, Koulmanda M, Kuchroo VK, Strom TB. Fragile TIM-4-expressing tissue resident macrophages are migratory and immunoregulatory. The Journal of Clinical Investigation. 124: 3443-54. PMID 24983317 DOI: 10.1172/JCI73527  0.44
2014 Kofler DM, Marson A, Dominguez-Villar M, Xiao S, Kuchroo VK, Hafler DA. Decreased RORC-dependent silencing of prostaglandin receptor EP2 induces autoimmune Th17 cells. The Journal of Clinical Investigation. 124: 2513-22. PMID 24812667 DOI: 10.1172/JCI72973  0.44
2014 da Silva IP, Gallois A, Jimenez-Baranda S, Khan S, Anderson AC, Kuchroo VK, Osman I, Bhardwaj N. Reversal of NK-cell exhaustion in advanced melanoma by Tim-3 blockade. Cancer Immunology Research. 2: 410-22. PMID 24795354 DOI: 10.1158/2326-6066.CIR-13-0171  0.44
2014 Joller N, Lozano E, Burkett PR, Patel B, Xiao S, Zhu C, Xia J, Tan TG, Sefik E, Yajnik V, Sharpe AH, Quintana FJ, Mathis D, Benoist C, Hafler DA, ... Kuchroo VK, et al. Treg cells expressing the coinhibitory molecule TIGIT selectively inhibit proinflammatory Th1 and Th17 cell responses. Immunity. 40: 569-81. PMID 24745333 DOI: 10.1016/j.immuni.2014.02.012  0.44
2014 Xiao S, Yosef N, Yang J, Wang Y, Zhou L, Zhu C, Wu C, Baloglu E, Schmidt D, Ramesh R, Lobera M, Sundrud MS, Tsai PY, Xiang Z, Wang J, ... ... Kuchroo VK, et al. Small-molecule RORγt antagonists inhibit T helper 17 cell transcriptional network by divergent mechanisms. Immunity. 40: 477-89. PMID 24745332 DOI: 10.1016/j.immuni.2014.04.004  0.44
2014 Czuczman MA, Fattouh R, van Rijn JM, Canadien V, Osborne S, Muise AM, Kuchroo VK, Higgins DE, Brumell JH. Listeria monocytogenes exploits efferocytosis to promote cell-to-cell spread. Nature. 509: 230-4. PMID 24739967 DOI: 10.1038/nature13168  0.44
2014 Angiari S, Donnarumma T, Rossi B, Dusi S, Pietronigro E, Zenaro E, DellaBianca V, Toffali L, Piacentino G, Budui S, Rennert P, Xiao S, Laudanna C, Casasnovas JM, Kuchroo VK, et al. TIM-1 glycoprotein binds the adhesion receptor P-selectin and mediates T cell trafficking during inflammation and autoimmunity Immunity. 40: 542-553. PMID 24703780 DOI: 10.1016/j.immuni.2014.03.004  0.44
2014 Vega-Carrascal I, Bergin DA, McElvaney OJ, McCarthy C, Banville N, Pohl K, Hirashima M, Kuchroo VK, Reeves EP, McElvaney NG. Galectin-9 signaling through TIM-3 is involved in neutrophil-mediated Gram-negative bacterial killing: an effect abrogated within the cystic fibrosis lung. Journal of Immunology (Baltimore, Md. : 1950). 192: 2418-31. PMID 24477913 DOI: 10.4049/jimmunol.1300711  0.44
2014 Fourcade J, Sun Z, Pagliano O, Chauvin JM, Sander C, Janjic B, Tarhini AA, Tawbi HA, Kirkwood JM, Moschos S, Wang H, Guillaume P, Luescher IF, Krieg A, Anderson AC, ... Kuchroo VK, et al. PD-1 and Tim-3 regulate the expansion of tumor antigen-specific CD8⁺ T cells induced by melanoma vaccines. Cancer Research. 74: 1045-55. PMID 24343228 DOI: 10.1158/0008-5472.CAN-13-2908  0.44
2013 Mascanfroni ID, Yeste A, Vieira SM, Burns EJ, Patel B, Sloma I, Wu Y, Mayo L, Ben-Hamo R, Efroni S, Kuchroo VK, Robson SC, Quintana FJ. IL-27 acts on DCs to suppress the T cell response and autoimmunity by inducing expression of the immunoregulatory molecule CD39. Nature Immunology. 14: 1054-63. PMID 23995234 DOI: 10.1038/ni.2695  0.44
2013 Lozano E, Joller N, Cao Y, Kuchroo VK, Hafler DA. The CD226/CD155 interaction regulates the proinflammatory (Th1/Th17)/anti-inflammatory (Th2) balance in humans. Journal of Immunology (Baltimore, Md. : 1950). 191: 3673-80. PMID 23980210 DOI: 10.4049/jimmunol.1300945  0.44
2013 Humphreys BD, Xu F, Sabbisetti V, Grgic I, Naini SM, Wang N, Chen G, Xiao S, Patel D, Henderson JM, Ichimura T, Mou S, Soeung S, McMahon AP, Kuchroo VK, et al. Chronic epithelial kidney injury molecule-1 expression causes murine kidney fibrosis. The Journal of Clinical Investigation. 123: 4023-35. PMID 23979159 DOI: 10.1172/JCI45361  0.44
2013 Jianjun Yang, Zhang R, Lu G, Shen Y, Peng L, Zhu C, Cui M, Wang W, Arnaboldi P, Tang M, Gupta M, Qi CF, Jayaraman P, Zhu H, Jiang B, ... ... Kuchroo VK, et al. T cell–derived inducible nitric oxide synthase switches off Th17 cell differentiation. The Journal of Experimental Medicine. 210: 1447-62. PMID 23797094 DOI: 10.1084/jem.20122494  0.44
2013 Sakuishi K, Ngiow SF, Sullivan JM, Teng MW, Kuchroo VK, Smyth MJ, Anderson AC. TIM3(+)FOXP3(+) regulatory T cells are tissue-specific promoters of T-cell dysfunction in cancer. Oncoimmunology. 2: e23849. PMID 23734331 DOI: 10.4161/onci.23849  0.44
2013 Wu C, Pot C, Apetoh L, Thalhamer T, Zhu B, Murugaiyan G, Xiao S, Lee Y, Rangachari M, Yosef N, Kuchroo VK. Metallothioneins negatively regulate IL-27-induced type 1 regulatory T-cell differentiation. Proceedings of the National Academy of Sciences of the United States of America. 110: 7802-7. PMID 23630250 DOI: 10.1073/pnas.1211776110  0.44
2013 Abbas AK, Benoist C, Bluestone JA, Campbell DJ, Ghosh S, Hori S, Jiang S, Kuchroo VK, Mathis D, Roncarolo MG, Rudensky A, Sakaguchi S, Shevach EM, Vignali DA, Ziegler SF. Regulatory T cells: recommendations to simplify the nomenclature. Nature Immunology. 14: 307-8. PMID 23507634 DOI: 10.1038/ni.2554  0.44
2013 Jayaraman P, Sada-Ovalle I, Nishimura T, Anderson AC, Kuchroo VK, Remold HG, Behar SM. IL-1β promotes antimicrobial immunity in macrophages by regulating TNFR signaling and caspase-3 activation. Journal of Immunology (Baltimore, Md. : 1950). 190: 4196-204. PMID 23487424 DOI: 10.4049/jimmunol.1202688  0.44
2013 Yosef N, Shalek AK, Gaublomme JT, Jin H, Lee Y, Awasthi A, Wu C, Karwacz K, Xiao S, Jorgolli M, Gennert D, Satija R, Shakya A, Lu DY, Trombetta JJ, ... ... Kuchroo VK, et al. Dynamic regulatory network controlling TH17 cell differentiation. Nature. 496: 461-8. PMID 23467089 DOI: 10.1038/nature11981  0.44
2013 Wu C, Yosef N, Thalhamer T, Zhu C, Xiao S, Kishi Y, Regev A, Kuchroo VK. Induction of pathogenic TH17 cells by inducible salt-sensing kinase SGK1. Nature. 496: 513-7. PMID 23467085 DOI: 10.1038/nature11984  0.44
2012 Balasubramanian S, Kota SK, Kuchroo VK, Humphreys BD, Strom TB. TIM family proteins promote the lysosomal degradation of the nuclear receptor NUR77. Science Signaling. 5: ra90. PMID 23233528 DOI: 10.1126/scisignal.2003200  0.44
2012 Lee Y, Awasthi A, Yosef N, Quintana FJ, Xiao S, Peters A, Wu C, Kleinewietfeld M, Kunder S, Hafler DA, Sobel RA, Regev A, Kuchroo VK. Induction and molecular signature of pathogenic TH17 cells. Nature Immunology. 13: 991-9. PMID 22961052 DOI: 10.1038/ni.2416  0.44
2012 Kuchroo VK, Awasthi A. Emerging new roles of Th17 cells. European Journal of Immunology. 42: 2211-4. PMID 22949318 DOI: 10.1002/eji.201242872  0.44
2012 Rangachari M, Zhu C, Sakuishi K, Xiao S, Karman J, Chen A, Angin M, Wakeham A, Greenfield EA, Sobel RA, Okada H, McKinnon PJ, Mak TW, Addo MM, Anderson AC, ... Kuchroo VK, et al. Bat3 promotes T cell responses and autoimmunity by repressing Tim-3–mediated cell death and exhaustion. Nature Medicine. 18: 1394-400. PMID 22863785 DOI: 10.1038/nm.2871  0.44
2012 Xiao S, Brooks CR, Zhu C, Wu C, Sweere JM, Petecka S, Yeste A, Quintana FJ, Ichimura T, Sobel RA, Bonventre JV, Kuchroo VK. Defect in regulatory B-cell function and development of systemic autoimmunity in T-cell Ig mucin 1 (Tim-1) mucin domain-mutant mice. Proceedings of the National Academy of Sciences of the United States of America. 109: 12105-10. PMID 22773818 DOI: 10.1073/pnas.1120914109  0.44
2012 Purwar R, Schlapbach C, Xiao S, Kang HS, Elyaman W, Jiang X, Jetten AM, Khoury SJ, Fuhlbrigge RC, Kuchroo VK, Clark RA, Kupper TS. Robust tumor immunity to melanoma mediated by interleukin-9-producing T cells. Nature Medicine. 18: 1248-53. PMID 22772464 DOI: 10.1038/nm.2856  0.44
2012 Quintana FJ, Jin H, Burns EJ, Nadeau M, Yeste A, Kumar D, Rangachari M, Zhu C, Xiao S, Seavitt J, Georgopoulos K, Kuchroo VK. Aiolos promotes TH17 differentiation by directly silencing Il2 expression. Nature Immunology. 13: 770-7. PMID 22751139 DOI: 10.1038/ni.2363  0.44
2012 Joller N, Peters A, Anderson AC, Kuchroo VK. Immune checkpoints in central nervous system autoimmunity. Immunological Reviews. 248: 122-39. PMID 22725958 DOI: 10.1111/j.1600-065X.2012.01136.x  0.44
2012 Gupta S, Thornley TB, Gao W, Larocca R, Turka LA, Kuchroo VK, Strom TB. Allograft rejection is restrained by short-lived TIM-3+PD-1+Foxp3+ Tregs. The Journal of Clinical Investigation. 122: 2395-404. PMID 22684103 DOI: 10.1172/JCI45138  0.44
2012 Veenstra RG, Taylor PA, Zhou Q, Panoskaltsis-Mortari A, Hirashima M, Flynn R, Liu D, Anderson AC, Strom TB, Kuchroo VK, Blazar BR. Contrasting acute graft-versus-host disease effects of Tim-3/galectin-9 pathway blockade dependent upon the presence of donor regulatory T cells. Blood. 120: 682-90. PMID 22677125 DOI: 10.1182/blood-2011-10-387977  0.44
2012 Fowler KD, Kuchroo VK, Chakraborty AK. A model for how signal duration can determine distinct outcomes of gene transcription programs. Plos One. 7: e33018. PMID 22427931 DOI: 10.1371/journal.pone.0033018  0.44
2012 Cedeno-Laurent F, Opperman M, Barthel SR, Kuchroo VK, Dimitroff CJ. Galectin-1 triggers an immunoregulatory signature in Th cells functionally defined by IL-10 expression. Journal of Immunology (Baltimore, Md. : 1950). 188: 3127-37. PMID 22345665 DOI: 10.4049/jimmunol.1103433  0.44
2012 Anderson AC, Chandwaskar R, Lee DH, Sullivan JM, Solomon A, Rodriguez-Manzanet R, Greve B, Sobel RA, Kuchroo VK. A transgenic model of central nervous system autoimmunity mediated by CD4+ and CD8+ T and B cells. Journal of Immunology (Baltimore, Md. : 1950). 188: 2084-92. PMID 22279107 DOI: 10.4049/jimmunol.1102186  0.44
2012 Kuchroo VK, Ohashi PS, Sartor RB, Vinuesa CG. Dysregulation of immune homeostasis in autoimmune diseases. Nature Medicine. 18: 42-7. PMID 22227671 DOI: 10.1038/nm.2621  0.44
2012 Liu SM, Sutherland APR, Zhang Z, Rainbow DB, Quintana FJ, Paterson AM, Sharpe AH, Oukka M, Wicker LS, Kuchroo VK. Overexpression of the CTLA-4 isoform lacking exons 2 and 3 causes autoimmunity Journal of Immunology. 188: 155-162. PMID 22124121 DOI: 10.4049/jimmunol.1102042  0.44
2011 Peters A, Pitcher LA, Sullivan JM, Mitsdoerffer M, Acton SE, Franz B, Wucherpfennig K, Turley S, Carroll MC, Sobel RA, Bettelli E, Kuchroo VK. Th17 cells induce ectopic lymphoid follicles in central nervous system tissue inflammation. Immunity. 35: 986-96. PMID 22177922 DOI: 10.1016/j.immuni.2011.10.015  0.44
2011 Liu SM, Lee DH, Sullivan JM, Chung D, Jäger A, Shum BO, Sarvetnick NE, Anderson AC, Kuchroo VK. Differential IL-21 signaling in APCs leads to disparate Th17 differentiation in diabetes-susceptible NOD and diabetes-resistant NOD.Idd3 mice. The Journal of Clinical Investigation. 121: 4303-10. PMID 22019586 DOI: 10.1172/JCI46187  0.44
2011 Awasthi A, Kuchroo VK. Value added: neural progenitor cells suppress inflammation and autoimmunity. Immunity. 35: 156-7. PMID 21867924 DOI: 10.1016/j.immuni.2011.08.005  0.44
2011 Esplugues E, Huber S, Gagliani N, Hauser AE, Town T, Wan YY, O'Connor W, Rongvaux A, Van Rooijen N, Haberman AM, Iwakura Y, Kuchroo VK, Kolls JK, Bluestone JA, Herold KC, et al. Control of TH17 cells occurs in the small intestine. Nature. 475: 514-8. PMID 21765430 DOI: 10.1038/nature10228  0.44
2011 Zhou Q, Munger ME, Veenstra RG, Weigel BJ, Hirashima M, Munn DH, Murphy WJ, Azuma M, Anderson AC, Kuchroo VK, Blazar BR. Coexpression of Tim-3 and PD-1 identifies a CD8+ T-cell exhaustion phenotype in mice with disseminated acute myelogenous leukemia. Blood. 117: 4501-10. PMID 21385853 DOI: 10.1182/blood-2010-10-310425  0.44
2011 Joller N, Hafler JP, Brynedal B, Kassam N, Spoerl S, Levin SD, Sharpe AH, Kuchroo VK. Cutting edge: TIGIT has T cell-intrinsic inhibitory functions. Journal of Immunology (Baltimore, Md. : 1950). 186: 1338-42. PMID 21199897 DOI: 10.4049/jimmunol.1003081  0.44
2011 Lazarevic V, Chen X, Shim JH, Hwang ES, Jang E, Bolm AN, Oukka M, Kuchroo VK, Glimcher LH. T-bet represses T(H)17 differentiation by preventing Runx1-mediated activation of the gene encoding RORγt. Nature Immunology. 12: 96-104. PMID 21151104 DOI: 10.1038/ni.1969  0.44
2010 Jayaraman P, Sada-Ovalle I, Beladi S, Anderson AC, Dardalhon V, Hotta C, Kuchroo VK, Behar SM. Tim3 binding to galectin-9 stimulates antimicrobial immunity. The Journal of Experimental Medicine. 207: 2343-54. PMID 20937702 DOI: 10.1084/jem.20100687  0.44
2010 Petermann F, Rothhammer V, Claussen MC, Haas JD, Blanco LR, Heink S, Prinz I, Hemmer B, Kuchroo VK, Oukka M, Korn T. γδ T cells enhance autoimmunity by restraining regulatory T cell responses via an interleukin-23-dependent mechanism. Immunity. 33: 351-63. PMID 20832339 DOI: 10.1016/j.immuni.2010.08.013  0.44
2010 Sakuishi K, Apetoh L, Sullivan JM, Blazar BR, Kuchroo VK, Anderson AC. Targeting Tim-3 and PD-1 pathways to reverse T cell exhaustion and restore anti-tumor immunity. The Journal of Experimental Medicine. 207: 2187-94. PMID 20819927 DOI: 10.1084/jem.20100643  0.44
2010 Strandberg LS, Ambrosi A, Jagodic M, Dzikaite V, Janson P, Khademi M, Salomonsson S, Ottosson L, Klauninger R, Adén U, Sonesson SE, Sunnerhagen M, de Graaf KL, Kuchroo VK, Achour A, et al. Maternal MHC regulates generation of pathogenic antibodies and fetal MHC-encoded genes determine susceptibility in congenital heart block. Journal of Immunology (Baltimore, Md. : 1950). 185: 3574-82. PMID 20696861 DOI: 10.4049/jimmunol.1001396  0.44
2008 Rodriguez-Manzanet R, Meyers JH, Balasubramanian S, Slavik J, Kassam N, Dardalhon V, Greenfield EA, Anderson AC, Sobel RA, Hafler DA, Strom TB, Kuchroo VK. TIM-4 expressed on APCs induces T cell expansion and survival. Journal of Immunology (Baltimore, Md. : 1950). 180: 4706-13. PMID 18354194  0.44
2006 Kuchroo VK, Meyers JH, Umetsu DT, DeKruyff RH. TIM family of genes in immunity and tolerance. Advances in Immunology. 91: 227-49. PMID 16938542 DOI: 10.1016/S0065-2776(06)91006-2  0.44
2005 Chakravarti S, Sabatos CA, Xiao S, Illes Z, Cha EK, Sobel RA, Zheng XX, Strom TB, Kuchroo VK. Tim-2 regulates T helper type 2 responses and autoimmunity. The Journal of Experimental Medicine. 202: 437-44. PMID 16043519 DOI: 10.1084/jem.20050308  0.44
2005 Dardalhon V, Schubart AS, Reddy J, Meyers JH, Monney L, Sabatos CA, Ahuja R, Nguyen K, Freeman GJ, Greenfield EA, Sobel RA, Kuchroo VK. CD226 is specifically expressed on the surface of Th1 cells and regulates their expansion and effector functions. Journal of Immunology (Baltimore, Md. : 1950). 175: 1558-65. PMID 16034094  0.44
2005 Meyers JH, Sabatos CA, Chakravarti S, Kuchroo VK. The TIM gene family regulates autoimmune and allergic diseases. Trends in Molecular Medicine. 11: 362-9. PMID 16002337 DOI: 10.1016/j.molmed.2005.06.008  0.44
2005 Meyers JH, Chakravarti S, Schlesinger D, Illes Z, Waldner H, Umetsu SE, Kenny J, Zheng XX, Umetsu DT, DeKruyff RH, Strom TB, Kuchroo VK. TIM-4 is the ligand for TIM-1, and the TIM-1-TIM-4 interaction regulates T cell proliferation. Nature Immunology. 6: 455-64. PMID 15793576 DOI: 10.1038/ni1185  0.44
2003 Sabatos CA, Chakravarti S, Cha E, Schubart A, Sánchez-Fueyo A, Zheng XX, Coyle AJ, Strom TB, Freeman GJ, Kuchroo VK. Interaction of Tim-3 and Tim-3 ligand regulates T helper type 1 responses and induction of peripheral tolerance. Nature Immunology. 4: 1102-10. PMID 14556006 DOI: 10.1038/ni988  0.44
2003 Sánchez-Fueyo A, Tian J, Picarella D, Domenig C, Zheng XX, Sabatos CA, Manlongat N, Bender O, Kamradt T, Kuchroo VK, Gutiérrez-Ramos JC, Coyle AJ, Strom TB. Tim-3 inhibits T helper type 1-mediated auto- and alloimmune responses and promotes immunological tolerance Nature Immunology. 4: 1093-1101. PMID 14556005 DOI: 10.1038/ni987  0.44
2002 Meyers JH, Ryu A, Monney L, Nguyen K, Greenfield EA, Freeman GJ, Kuchroo VK. Cutting edge: CD94/NKG2 is expressed on Th1 but not Th2 cells and costimulates Th1 effector functions. Journal of Immunology (Baltimore, Md. : 1950). 169: 5382-6. PMID 12421909  0.44
2002 Monney L, Sabatos CA, Gaglia JL, Ryu A, Waldner H, Chernova T, Manning S, Greenfield EA, Coyle AJ, Sobel RA, Freeman GJ, Kuchroo VK. Th1-specific cell surface protein Tim-3 regulates macrophage activation and severity of an autoimmune disease. Nature. 415: 536-41. PMID 11823861 DOI: 10.1038/415536a  0.44
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