Aimee Edinger - Publications

Biological Sciences - Ph.D. University of California, Irvine, Irvine, CA 
Cell Biology

46 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Bachollet SPJT, Vece V, McCracken AN, Finicle BT, Selwan E, Ben Romdhane N, Dahal A, Ramirez C, Edinger AL, Hanessian S. Synthetic Sphingolipids with 1,2-Pyridazine Appendages Improve Antiproliferative Activity in Human Cancer Cell Lines. Acs Medicinal Chemistry Letters. 11: 686-690. PMID 32435371 DOI: 10.1021/Acsmedchemlett.9B00553  0.36
2020 Kemp JA, Keebaugh A, Edson JA, Chow D, Kleinman MT, Chew YC, McCracken AN, Edinger AL, Kwon YJ. Biocompatible Chemotherapy for Leukemia by Acid-Cleavable, PEGylated FTY720. Bioconjugate Chemistry. PMID 31986014 DOI: 10.1021/Acs.Bioconjchem.9B00822  0.36
2019 Kubiniok P, Finicle BT, Piffaretti F, McCracken AN, Perryman M, Hanessian S, Edinger AL, Thibault P. Dynamic Phosphoproteomics Uncovers Signaling Pathways Modulated by Anti-oncogenic Sphingolipid Analogs. Molecular & Cellular Proteomics : McP. 18: 408-422. PMID 33431118 DOI: 10.1074/mcp.RA118.001053  0.36
2019 Garsi JB, Vece V, Sernissi L, Auger-Morin C, Hanessian S, McCracken AN, Selwan E, Ramirez C, Dahal A, Romdhane NB, Finicle BT, Edinger AL. Design, synthesis and anticancer activity of constrained sphingolipid-phenoxazine/phenothiazine hybrid constructs targeting protein phosphatase 2A. Bioorganic & Medicinal Chemistry Letters. PMID 31383588 DOI: 10.1016/J.Bmcl.2019.07.023  0.36
2018 Kubiniok P, Finicle BT, Piffaretti F, McCracken AN, Perryman M, Hanessian S, Edinger AL, Thibault P. Dynamic phosphoproteomics uncovers signaling pathways modulated by anti-neoplastic sphingolipid analogs. Molecular & Cellular Proteomics : McP. PMID 30482847 DOI: 10.1074/Mcp.Ra118.001053  0.36
2018 Garsi JB, Sernissi L, Vece V, Hanessian S, McCracken AN, Simitian G, Edinger AL. In search of constrained FTY720 and phytosphingosine analogs as dual acting anticancer agents targeting metabolic and epigenetic pathways. European Journal of Medicinal Chemistry. 159: 217-242. PMID 30292898 DOI: 10.1016/J.Ejmech.2018.09.043  0.36
2018 Finicle BT, Ramirez MU, Liu G, Selwan EM, McCracken AN, Yu J, Joo Y, Nguyen J, Ou K, Ghosh Roy S, Mendoza VD, Corrales DV, Edinger AL. Sphingolipids inhibit endosomal recycling of nutrient transporters by inactivating ARF6. Journal of Cell Science. PMID 29848659 DOI: 10.1242/jcs.213314  0.36
2018 Kim SM, Nguyen TT, Ravi A, Kubiniok P, Finicle BT, Jayashankar V, Malacrida L, Hou J, Robertson J, Gao D, Chernoff J, Digman MA, Potma EO, Tromberg BJ, Thibault P, ... Edinger AL, et al. PTEN deficiency and AMPK activation promote nutrient scavenging and anabolism in prostate cancer cells. Cancer Discovery. PMID 29572236 DOI: 10.1158/2159-8290.Cd-17-1215  0.36
2016 Kim SM, Roy SG, Chen B, Nguyen TM, McMonigle RJ, McCracken AN, Zhang Y, Kofuji S, Hou J, Selwan E, Finicle BT, Nguyen TT, Ravi A, Ramirez MU, Wiher T, ... ... Edinger AL, et al. Targeting cancer metabolism by simultaneously disrupting parallel nutrient access pathways. The Journal of Clinical Investigation. PMID 27669461 DOI: 10.1172/Jci87148  1
2016 McCracken AN, McMonigle RJ, Tessier J, Fransson R, Perryman MS, Chen B, Keebaugh A, Selwan E, Barr SA, Kim SM, Roy SG, Liu G, Fallegger D, Sernissi L, Brandt C, ... ... Edinger AL, et al. Phosphorylation of a constrained azacyclic FTY720 analog enhances anti-leukemic activity without inducing S1P receptor activation. Leukemia. PMID 27573555 DOI: 10.1038/Leu.2016.244  0.36
2016 Perryman MS, Tessier J, Wiher T, O'Donoghue H, McCracken AN, Kim SM, Nguyen DG, Simitian GS, Viana M, Rafelski S, Edinger AL, Hanessian S. Effects of stereochemistry, saturation, and hydrocarbon chain length on the ability of synthetic constrained azacyclic sphingolipids to trigger nutrient transporter down-regulation, vacuolation, and cell death. Bioorganic & Medicinal Chemistry. PMID 27475534 DOI: 10.1016/J.Bmc.2016.07.038  0.36
2016 Walker WP, Oehler A, Edinger AL, Wagner KU, Gunn TM. Oligodendroglial deletion of ESCRT-I component TSG101 causes spongiform encephalopathy. Biology of the Cell / Under the Auspices of the European Cell Biology Organization. PMID 27406702 DOI: 10.1111/Boc.201600014  0.36
2016 Selwan E, Finicle BT, Kim SM, Edinger AL. Attacking the supply wagons to starve cancer cells to death. Febs Letters. PMID 26938658 DOI: 10.1002/1873-3468.12121  0.36
2015 Chen B, Roy SG, McMonigle RJ, Keebaugh A, McCracken AN, Selwan E, Fransson R, Fallegger D, Huwiler A, Kleinman MT, Edinger AL, Hanessian S. Azacyclic FTY720 Analogues That Limit Nutrient Transporter Expression but Lack S1P Receptor Activity and Negative Chronotropic Effects Offer a Novel and Effective Strategy to Kill Cancer Cells in Vivo. Acs Chemical Biology. PMID 26653336 DOI: 10.1021/Acschembio.5B00761  0.36
2015 McCracken AN, Edinger AL. Targeting cancer metabolism at the plasma membrane by limiting amino acid access through SLC6A14. The Biochemical Journal. 470: e17-9. PMID 26341486 DOI: 10.1042/BJ20150721  0.36
2015 Holden JK, Kang S, Beasley FC, Cinelli MA, Li H, Roy SG, Dejam D, Edinger AL, Nizet V, Silverman RB, Poulos TL. Nitric Oxide Synthase as a Target for Methicillin-Resistant Staphylococcus aureus. Chemistry & Biology. 22: 785-92. PMID 26091171 DOI: 10.1016/J.Chembiol.2015.05.013  0.36
2015 Pone EJ, Lam T, Lou Z, Wang R, Chen Y, Liu D, Edinger AL, Xu Z, Casali P. B cell Rab7 mediates induction of activation-induced cytidine deaminase expression and class-switching in T-dependent and T-independent antibody responses. Journal of Immunology (Baltimore, Md. : 1950). 194: 3065-78. PMID 25740947 DOI: 10.4049/Jimmunol.1401896  0.36
2014 Guenther GG, Liu G, Ramirez MU, Mcmonigle RJ, Kim SM, Mccracken AN, Joo Y, Ushach I, Nguyen NL, Edinger AL. Loss of TSC2 confers resistance to ceramide and nutrient deprivation Oncogene. 33: 1776-1787. PMID 23604129 DOI: 10.1038/onc.2013.139  0.36
2013 Fransson R, McCracken AN, Chen B, McMonigle RJ, Edinger AL, Hanessian S. Design, Synthesis, and Anti-leukemic Activity of Stereochemically Defined Constrained Analogs of FTY720 (Gilenya). Acs Medicinal Chemistry Letters. 4. PMID 24273632 DOI: 10.1021/Ml4002425  0.36
2013 McCracken AN, Edinger AL. Nutrient transporters: the Achilles' heel of anabolism. Trends in Endocrinology and Metabolism: Tem. 24: 200-8. PMID 23402769 DOI: 10.1016/j.tem.2013.01.002  0.36
2011 Romero Rosales K, Singh G, Wu K, Chen J, Janes MR, Lilly MB, Peralta ER, Siskind LJ, Bennett MJ, Fruman DA, Edinger AL. Sphingolipid-based drugs selectively kill cancer cells by down-regulating nutrient transporter proteins. The Biochemical Journal. 439: 299-311. PMID 21767261 DOI: 10.1042/Bj20110853  0.36
2010 Peralta ER, Martin BC, Edinger AL. Differential effects of TBC1D15 and mammalian Vps39 on Rab7 activation state, lysosomal morphology, and growth factor dependence. The Journal of Biological Chemistry. 285: 16814-21. PMID 20363736 DOI: 10.1074/Jbc.M110.111633  0.36
2010 Siskind LJ, Mullen TD, Romero Rosales K, Clarke CJ, Hernandez-Corbacho MJ, Edinger AL, Obeid LM. The BCL-2 protein BAK is required for long-chain ceramide generation during apoptosis. The Journal of Biological Chemistry. 285: 11818-26. PMID 20172858 DOI: 10.1074/Jbc.M109.078121  0.6
2009 Romero Rosales K, Peralta ER, Guenther GG, Wong SY, Edinger AL. Rab7 activation by growth factor withdrawal contributes to the induction of apoptosis. Molecular Biology of the Cell. 20: 2831-40. PMID 19386765 DOI: 10.1091/Mbc.E08-09-0911  1
2009 Guenther GG, Edinger AL. A new take on ceramide: starving cells by cutting off the nutrient supply. Cell Cycle (Georgetown, Tex.). 8: 1122-6. PMID 19282666 DOI: 10.4161/cc.8.8.8161  1
2009 Peralta ER, Edinger AL. Ceramide-induced starvation triggers homeostatic autophagy. Autophagy. 5: 407-9. PMID 19202357 DOI: 10.4161/Auto.5.3.7809  0.92
2008 Guenther GG, Peralta ER, Rosales KR, Wong SY, Siskind LJ, Edinger AL. Ceramide starves cells to death by downregulating nutrient transporter proteins. Proceedings of the National Academy of Sciences of the United States of America. 105: 17402-7. PMID 18981422 DOI: 10.1073/Pnas.0802781105  1
2004 Edinger AL, Thompson CB. Death by design: apoptosis, necrosis and autophagy. Current Opinion in Cell Biology. 16: 663-9. PMID 15530778 DOI: 10.1016/J.Ceb.2004.09.011  0.36
2004 Edinger AL, Thompson CB. An activated mTOR mutant supports growth factor-independent, nutrient-dependent cell survival. Oncogene. 23: 5654-63. PMID 15133498 DOI: 10.1038/Sj.Onc.1207738  0.36
2003 Edinger AL, Thompson CB. Defective autophagy leads to cancer. Cancer Cell. 4: 422-4. PMID 14706333 DOI: 10.1016/S1535-6108(03)00306-4  0.36
2003 Edinger AL, Linardic CM, Chiang GG, Thompson CB, Abraham RT. Differential effects of rapamycin on mammalian target of rapamycin signaling functions in mammalian cells. Cancer Research. 63: 8451-60. PMID 14679009  0.36
2003 Edinger AL, Cinalli RM, Thompson CB. Rab7 prevents growth factor-independent survival by inhibiting cell-autonomous nutrient transporter expression. Developmental Cell. 5: 571-82. PMID 14536059 DOI: 10.1016/S1534-5807(03)00291-0  0.36
2002 Edinger AL, Thompson CB. Akt maintains cell size and survival by increasing mTOR-dependent nutrient uptake. Molecular Biology of the Cell. 13: 2276-88. PMID 12134068 DOI: 10.1091/Mbc.01-12-0584  0.36
2002 Puffer BA, Pöhlmann S, Edinger AL, Carlin D, Sanchez MD, Reitter J, Watry DD, Fox HS, Desrosiers RC, Doms RW. CD4 independence of simian immunodeficiency virus Envs is associated with macrophage tropism, neutralization sensitivity, and attenuated pathogenicity. Journal of Virology. 76: 2595-605. PMID 11861825 DOI: 10.1128/Jvi.76.6.2595-2605.2002  0.36
2002 Edinger AL, Thompson CB. Antigen-presenting cells control T cell proliferation by regulating amino acid availability. Proceedings of the National Academy of Sciences of the United States of America. 99: 1107-9. PMID 11830651 DOI: 10.1073/Pnas.042707999  0.36
2001 Plas DR, Talapatra S, Edinger AL, Rathmell JC, Thompson CB. Akt and Bcl-xL promote growth factor-independent survival through distinct effects on mitochondrial physiology. The Journal of Biological Chemistry. 276: 12041-8. PMID 11278698 DOI: 10.1074/Jbc.M010551200  0.36
2000 Edinger AL, Ahuja M, Sung T, Baxter KC, Haggarty B, Doms RW, Hoxie JA. Characterization and epitope mapping of neutralizing monoclonal antibodies produced by immunization with oligomeric simian immunodeficiency virus envelope protein Journal of Virology. 74: 7922-7935. PMID 10933700 DOI: 10.1128/Jvi.74.17.7922-7935.2000  0.36
1999 Edinger AL, Clements JE, Doms RW. Chemokine and orphan receptors in HIV-2 and SIV tropism and pathogenesis Virology. 260: 211-221. PMID 10417256 DOI: 10.1006/Viro.1999.9819  0.36
1999 Edinger AL, Blanpain C, Kunstman KJ, Wolinsky SM, Parmentier M, Doms RW. Functional dissection of CCR5 coreceptor function through the use of CD4-independent simian immunodeficiency virus strains. Journal of Virology. 73: 4062-73. PMID 10196302 DOI: 10.1128/Jvi.73.5.4062-4073.1999  0.36
1999 Martin V, Ronde P, Unett D, Wong A, Hoffman TL, Edinger AL, Doms RW, Funk CD. Leukotriene binding, signaling, and analysis of HIV coreceptor function in mouse and human leukotriene B4 receptor-transfected cells. The Journal of Biological Chemistry. 274: 8597-603. PMID 10085095 DOI: 10.1074/jbc.274.13.8597  0.36
1998 Edinger AL, Hoffman TL, Sharron M, Lee B, O'Dowd B, Doms RW. Use of GPR1, GPR15, and STRL33 as coreceptors by diverse human immunodeficiency virus type 1 and simian immunodeficiency virus envelope proteins. Virology. 249: 367-78. PMID 9791028 DOI: 10.1006/Viro.1998.9306  0.36
1998 Edinger AL, Hoffman TL, Sharron M, Lee B, Yi Y, Choe W, Kolson DL, Mitrovic B, Zhou Y, Faulds D, Collman RG, Hesselgesser J, Horuk R, Doms RW. An orphan seven-transmembrane domain receptor expressed widely in the brain functions as a coreceptor for human immunodeficiency virus type 1 and simian immunodeficiency virus. Journal of Virology. 72: 7934-40. PMID 9733831 DOI: 10.1128/Jvi.72.10.7934-7940.1998  0.36
1997 Edinger AL, Mankowski JL, Doranz BJ, Margulies BJ, Lee B, Rucker J, Sharron M, Hoffman TL, Berson JF, Zink MC, Hirsch VM, Clements JE, Doms RW. CD4-independent, CCR5-dependent infection of brain capillary endothelial cells by a neurovirulent simian immunodeficiency virus strain. Proceedings of the National Academy of Sciences of the United States of America. 94: 14742-7. PMID 9405683 DOI: 10.1073/Pnas.94.26.14742  0.36
1997 Rucker J, Edinger AL, Sharron M, Samson M, Lee B, Berson JF, Yi Y, Margulies B, Collman RG, Doranz BJ, Parmentier M, Doms RW. Utilization of chemokine receptors, orphan receptors, and herpesvirus-encoded receptors by diverse human and simian immunodeficiency viruses. Journal of Virology. 71: 8999-9007. PMID 9371556 DOI: 10.1128/Jvi.71.12.8999-9007.1997  0.36
1997 Rucker J, Doranz BJ, Edinger AL, Long D, Berson JF, Doms RW. Cell-cell fusion assay to study role of chemokine receptors in human immunodeficiency virus type 1 entry. Methods in Enzymology. 288: 118-33. PMID 9356991 DOI: 10.1016/S0076-6879(97)88011-1  0.36
1997 Edinger AL, Amedee A, Miller K, Doranz BJ, Endres M, Sharron M, Samson M, Lu ZH, Clements JE, Murphey-Corb M, Peiper SC, Parmentier M, Broder CC, Doms RW. Differential utilization of CCR5 by macrophage and T cell tropic simian immunodeficiency virus strains. Proceedings of the National Academy of Sciences of the United States of America. 94: 4005-10. PMID 9108095 DOI: 10.1073/Pnas.94.8.4005  0.36
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