Jeffrey Rathmell - Publications

Affiliations: 
Molecular Cancer Biology Duke University, Durham, NC 
Area:
Cell Biology, Oncology, Molecular Biology

82 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Sinclair LV, Howden AJ, Brenes A, Spinelli L, Hukelmann JL, Macintyre AN, Liu X, Thomson S, Taylor PM, Rathmell JC, Locasale JW, Lamond AI, Cantrell DA. Antigen receptor control of methionine metabolism in T cells. Elife. 8. PMID 30916644 DOI: 10.7554/eLife.44210  0.4
2019 Gemta LF, Siska PJ, Nelson ME, Gao X, Liu X, Locasale JW, Yagita H, Slingluff CL, Hoehn KL, Rathmell JC, Bullock TNJ. Impaired enolase 1 glycolytic activity restrains effector functions of tumor-infiltrating CD8 T cells. Science Immunology. 4. PMID 30683669 DOI: 10.1126/sciimmunol.aap9520  0.32
2018 Johnson MO, Wolf MM, Madden MZ, Andrejeva G, Sugiura A, Contreras DC, Maseda D, Liberti MV, Paz K, Kishton RJ, Johnson ME, de Cubas AA, Wu P, Li G, Zhang Y, ... ... Rathmell JC, et al. Distinct Regulation of Th17 and Th1 Cell Differentiation by Glutaminase-Dependent Metabolism. Cell. PMID 30392958 DOI: 10.1016/j.cell.2018.10.001  0.32
2017 Liberti MV, Dai Z, Wardell SE, Baccile JA, Liu X, Gao X, Baldi R, Mehrmohamadi M, Johnson MO, Madhukar NS, Shestov AA, Chio IIC, Elemento O, Rathmell JC, Schroeder FC, et al. A Predictive Model for Selective Targeting of the Warburg Effect through GAPDH Inhibition with a Natural Product. Cell Metabolism. PMID 28918937 DOI: 10.1016/j.cmet.2017.08.017  0.32
2017 MacIver NJ, Rathmell JC. Editorial overview: Metabolism of T cells: integrating nutrients, signals, and cell fate. Current Opinion in Immunology. PMID 28684058 DOI: 10.1016/j.coi.2017.06.002  0.88
2017 Schmidt EA, Fee BE, Henry SC, Nichols AG, Shinohara ML, Rathmell JC, MacIver NJ, Coers J, Ilkayeva OR, Koves TR, Taylor GA. Metabolic alterations contribute to enhanced inflammatory cytokine production in Irgm1-deficient macrophages. The Journal of Biological Chemistry. PMID 28154172 DOI: 10.1074/jbc.M116.770735  0.88
2016 Gerriets VA, Kishton RJ, Johnson MO, Cohen S, Siska PJ, Nichols AG, Warmoes MO, de Cubas AA, MacIver NJ, Locasale JW, Turka LA, Wells AD, Rathmell JC. Foxp3 and Toll-like receptor signaling balance Treg cell anabolic metabolism for suppression. Nature Immunology. PMID 27695003 DOI: 10.1038/ni.3577  0.88
2016 Zeng H, Cohen S, Guy C, Shrestha S, Neale G, Brown SA, Cloer C, Kishton RJ, Gao X, Youngblood B, Do M, Li MO, Locasale JW, Rathmell JC, Chi H. mTORC1 and mTORC2 Kinase Signaling and Glucose Metabolism Drive Follicular Helper T Cell Differentiation. Immunity. PMID 27637146 DOI: 10.1016/j.immuni.2016.08.017  1
2016 Siska PJ, Kim B, Ji X, Hoeksema MD, Massion PP, Beckermann KE, Wu J, Chi JT, Hong J, Rathmell JC. Fluorescence-based measurement of cystine uptake through xCT shows requirement for ROS detoxification in activated lymphocytes. Journal of Immunological Methods. PMID 27594594 DOI: 10.1016/j.jim.2016.08.013  1
2016 Siska PJ, van der Windt GJ, Kishton RJ, Cohen S, Eisner W, MacIver NJ, Kater AP, Weinberg JB, Rathmell JC. Suppression of Glut1 and Glucose Metabolism by Decreased Akt/mTORC1 Signaling Drives T Cell Impairment in B Cell Leukemia. Journal of Immunology (Baltimore, Md. : 1950). PMID 27511728 DOI: 10.4049/jimmunol.1502464  1
2016 Kishton RJ, Barnes CE, Nichols AG, Cohen S, Gerriets VA, Siska PJ, Macintyre AN, Goraksha-Hicks P, de Cubas AA, Liu T, Warmoes MO, Abel ED, Yeoh AE, Gershon TR, Rathmell WK, ... ... Rathmell JC, et al. AMPK Is Essential to Balance Glycolysis and Mitochondrial Metabolism to Control T-ALL Cell Stress and Survival. Cell Metabolism. 23: 649-62. PMID 27076078 DOI: 10.1016/j.cmet.2016.03.008  1
2016 Park S, Chang CY, Safi R, Liu X, Baldi R, Jasper JS, Anderson GR, Liu T, Rathmell JC, Dewhirst MW, Wood KC, Locasale JW, McDonnell DP. ERRα Regulated Lactate Metabolism Contributes to Resistance to Targeted Therapies in Breast Cancer. Cell Reports. PMID 27050525 DOI: 10.1016/j.celrep.2016.03.026  1
2016 Hosios AM, Hecht VC, Danai LV, Johnson MO, Rathmell JC, Steinhauser ML, Manalis SR, Vander Heiden MG. Amino Acids Rather than Glucose Account for the Majority of Cell Mass in Proliferating Mammalian Cells. Developmental Cell. 36: 540-9. PMID 26954548 DOI: 10.1016/j.devcel.2016.02.012  1
2016 McFadden K, Hafez AY, Kishton R, Messinger JE, Nikitin PA, Rathmell JC, Luftig MA. Metabolic stress is a barrier to Epstein-Barr virus-mediated B-cell immortalization. Proceedings of the National Academy of Sciences of the United States of America. PMID 26802124 DOI: 10.1073/pnas.1517141113  1
2015 Kang S, Keener AB, Jones SZ, Benschop RJ, Caro-Maldonado A, Rathmell JC, Clarke SH, Matsushima GK, Whitmire JK, Vilen BJ. IgG-Immune Complexes Promote B Cell Memory by Inducing BAFF. Journal of Immunology (Baltimore, Md. : 1950). PMID 26621863 DOI: 10.4049/jimmunol.1402527  1
2015 Hirschey MD, DeBerardinis RJ, Diehl AM, Drew JE, Frezza C, Green MF, Jones LW, Ko YH, Le A, Lea MA, Locasale JW, Longo VD, Lyssiotis CA, McDonnell E, Mehrmohamadi M, ... ... Rathmell JC, et al. Dysregulated metabolism contributes to oncogenesis. Seminars in Cancer Biology. PMID 26454069 DOI: 10.1016/j.semcancer.2015.10.002  1
2015 Altman BJ, Hsieh AL, Sengupta A, Krishnanaiah SY, Stine ZE, Walton ZE, Gouw AM, Venkataraman A, Li B, Goraksha-Hicks P, Diskin SJ, Bellovin DI, Simon MC, Rathmell JC, Lazar MA, et al. MYC Disrupts the Circadian Clock and Metabolism in Cancer Cells. Cell Metabolism. 22: 1009-19. PMID 26387865 DOI: 10.1016/j.cmet.2015.09.003  1
2015 Ho PC, Bihuniak JD, Macintyre AN, Staron M, Liu X, Amezquita R, Tsui YC, Cui G, Micevic G, Perales JC, Kleinstein SH, Abel ED, Insogna KL, Feske S, Locasale JW, ... ... Rathmell JC, et al. Phosphoenolpyruvate Is a Metabolic Checkpoint of Anti-tumor T Cell Responses. Cell. PMID 26321681 DOI: 10.1016/j.cell.2015.08.012  1
2015 Murray PJ, Rathmell J, Pearce E. SnapShot: Immunometabolism. Cell Metabolism. 22: 190-190.e1. PMID 26154058 DOI: 10.1016/j.cmet.2015.06.014  1
2015 Zhang M, Qiu Q, Li Z, Sachdeva M, Min H, Cardona DM, DeLaney TF, Han T, Ma Y, Luo L, Ilkayeva OR, Lui K, Nichols AG, Newgard CB, Kastan MB, ... Rathmell JC, et al. HIF-1 Alpha Regulates the Response of Primary Sarcomas to Radiation Therapy through a Cell Autonomous Mechanism. Radiation Research. 183: 594-609. PMID 25973951 DOI: 10.1667/RR14016.1  1
2015 Huynh A, DuPage M, Priyadharshini B, Sage PT, Quiros J, Borges CM, Townamchai N, Gerriets VA, Rathmell JC, Sharpe AH, Bluestone JA, Turka LA. Control of PI(3) kinase in Treg cells maintains homeostasis and lineage stability. Nature Immunology. 16: 188-96. PMID 25559257 DOI: 10.1038/ni.3077  1
2015 Kountikov EI, Poe JC, Maclver NJ, Rathmell JC, Tedder TF. A spontaneous deletion within the desmoglein 3 extracellular domain of mice results in hypomorphic protein expression, immunodeficiency, and a wasting disease phenotype. The American Journal of Pathology. 185: 617-30. PMID 25542773 DOI: 10.1016/j.ajpath.2014.10.025  1
2015 Gerriets VA, Kishton RJ, Nichols AG, Macintyre AN, Inoue M, Ilkayeva O, Winter PS, Liu X, Priyadharshini B, Slawinska ME, Haeberli L, Huck C, Turka LA, Wood KC, Hale LP, ... ... Rathmell JC, et al. Metabolic programming and PDHK1 control CD4+ T cell subsets and inflammation. The Journal of Clinical Investigation. 125: 194-207. PMID 25437876 DOI: 10.1172/JCI76012  1
2014 Martz CA, Ottina KA, Singleton KR, Jasper JS, Wardell SE, Peraza-Penton A, Anderson GR, Winter PS, Wang T, Alley HM, Kwong LN, Cooper ZA, Tetzlaff M, Chen PL, Rathmell JC, et al. Systematic identification of signaling pathways with potential to confer anticancer drug resistance. Science Signaling. 7: ra121. PMID 25538079 DOI: 10.1126/scisignal.aaa1877  1
2014 Cao Y, Rathmell JC, Macintyre AN. Metabolic reprogramming towards aerobic glycolysis correlates with greater proliferative ability and resistance to metabolic inhibition in CD8 versus CD4 T cells. Plos One. 9: e104104. PMID 25090630 DOI: 10.1371/journal.pone.0104104  1
2014 Macintyre AN, Gerriets VA, Nichols AG, Michalek RD, Rudolph MC, Deoliveira D, Anderson SM, Abel ED, Chen BJ, Hale LP, Rathmell JC. The glucose transporter Glut1 is selectively essential for CD4 T cell activation and effector function. Cell Metabolism. 20: 61-72. PMID 24930970 DOI: 10.1016/j.cmet.2014.05.004  1
2014 Arreola A, Cowey CL, Coloff JL, Rathmell JC, Rathmell WK. HIF1α and HIF2α exert distinct nutrient preferences in renal cells. Plos One. 9: e98705. PMID 24879016 DOI: 10.1371/journal.pone.0098705  1
2014 Caro-Maldonado A, Wang R, Nichols AG, Kuraoka M, Milasta S, Sun LD, Gavin AL, Abel ED, Kelsoe G, Green DR, Rathmell JC. Metabolic reprogramming is required for antibody production that is suppressed in anergic but exaggerated in chronically BAFF-exposed B cells. Journal of Immunology (Baltimore, Md. : 1950). 192: 3626-36. PMID 24616478 DOI: 10.4049/jimmunol.1302062  1
2014 Saucillo DC, Gerriets VA, Sheng J, Rathmell JC, Maciver NJ. Leptin metabolically licenses T cells for activation to link nutrition and immunity. Journal of Immunology (Baltimore, Md. : 1950). 192: 136-44. PMID 24273001 DOI: 10.4049/jimmunol.1301158  0.88
2013 Macintyre AN, Rathmell JC. Activated lymphocytes as a metabolic model for carcinogenesis. Cancer & Metabolism. 1: 5. PMID 24280044 DOI: 10.1186/2049-3002-1-5  0.4
2013 Kim JS, Sklarz T, Banks LB, Gohil M, Waickman AT, Skuli N, Krock BL, Luo CT, Hu W, Pollizzi KN, Li MO, Rathmell JC, Birnbaum MJ, Powell JD, Jordan MS, et al. Natural and inducible TH17 cells are regulated differently by Akt and mTOR pathways. Nature Immunology. 14: 611-8. PMID 23644504 DOI: 10.1038/ni.2607  1
2013 McCarthy SA, Mufson RA, Pearce EJ, Rathmell JC, Howcroft TK. Metabolic reprogramming of the immune response in the tumor microenvironment. Cancer Biology & Therapy. 14: 315-8. PMID 23358474 DOI: 10.4161/cbt.23616  1
2013 Kurokawa M, Ito T, Yang CS, Zhao C, Macintyre AN, Rizzieri DA, Rathmell JC, Deininger MW, Reya T, Kornbluth S. Engineering a BCR-ABL-activated caspase for the selective elimination of leukemic cells. Proceedings of the National Academy of Sciences of the United States of America. 110: 2300-5. PMID 23324740 DOI: 10.1073/pnas.1206551110  1
2013 MacIver NJ, Michalek RD, Rathmell JC. Metabolic regulation of T lymphocytes. Annual Review of Immunology. 31: 259-83. PMID 23298210 DOI: 10.1146/annurev-immunol-032712-095956  0.88
2012 Klionsky DJ, Abdalla FC, Abeliovich H, Abraham RT, Acevedo-Arozena A, Adeli K, Agholme L, Agnello M, Agostinis P, Aguirre-Ghiso JA, Ahn HJ, Ait-Mohamed O, Ait-Si-Ali S, Akematsu T, Akira S, ... ... Rathmell JC, et al. Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy. 8: 445-544. PMID 22966490  0.52
2012 Altman BJ, Rathmell JC. Metabolic stress in autophagy and cell death pathways. Cold Spring Harbor Perspectives in Biology. 4: a008763. PMID 22952396 DOI: 10.1101/cshperspect.a008763  0.92
2012 Bhatt AP, Jacobs SR, Freemerman AJ, Makowski L, Rathmell JC, Dittmer DP, Damania B. Dysregulation of fatty acid synthesis and glycolysis in non-Hodgkin lymphoma. Proceedings of the National Academy of Sciences of the United States of America. 109: 11818-23. PMID 22752304 DOI: 10.1073/pnas.1205995109  1
2011 Michalek RD, Gerriets VA, Nichols AG, Inoue M, Kazmin D, Chang CY, Dwyer MA, Nelson ER, Pollizzi KN, Ilkayeva O, Giguere V, Zuercher WJ, Powell JD, Shinohara ML, McDonnell DP, ... Rathmell JC, et al. Estrogen-related receptor-α is a metabolic regulator of effector T-cell activation and differentiation. Proceedings of the National Academy of Sciences of the United States of America. 108: 18348-53. PMID 22042850 DOI: 10.1073/pnas.1108856108  1
2011 Nelson ER, DuSell CD, Wang X, Howe MK, Evans G, Michalek RD, Umetani M, Rathmell JC, Khosla S, Gesty-Palmer D, McDonnell DP. The oxysterol, 27-hydroxycholesterol, links cholesterol metabolism to bone homeostasis through its actions on the estrogen and liver X receptors. Endocrinology. 152: 4691-705. PMID 21933863 DOI: 10.1210/en.2011-1298  0.44
2011 MacIver NJ, Blagih J, Saucillo DC, Tonelli L, Griss T, Rathmell JC, Jones RG. The liver kinase B1 is a central regulator of T cell development, activation, and metabolism. Journal of Immunology (Baltimore, Md. : 1950). 187: 4187-98. PMID 21930968 DOI: 10.4049/jimmunol.1100367  1
2011 Macintyre AN, Rathmell JC. PKM2 and the tricky balance of growth and energy in cancer. Molecular Cell. 42: 713-4. PMID 21700216 DOI: 10.1016/j.molcel.2011.06.003  1
2011 Coloff JL, Macintyre AN, Nichols AG, Liu T, Gallo CA, Plas DR, Rathmell JC. Akt-dependent glucose metabolism promotes Mcl-1 synthesis to maintain cell survival and resistance to Bcl-2 inhibition. Cancer Research. 71: 5204-13. PMID 21670080 DOI: 10.1158/0008-5472.CAN-10-4531  1
2011 Horn SR, Thomenius MJ, Johnson ES, Freel CD, Wu JQ, Coloff JL, Yang CS, Tang W, An J, Ilkayeva OR, Rathmell JC, Newgard CB, Kornbluth S. Regulation of mitochondrial morphology by APC/CCdh1-mediated control of Drp1 stability. Molecular Biology of the Cell. 22: 1207-16. PMID 21325626 DOI: 10.1091/mbc.E10-07-0567  1
2011 Michalek RD, Gerriets VA, Jacobs SR, Macintyre AN, MacIver NJ, Mason EF, Sullivan SA, Nichols AG, Rathmell JC. Cutting edge: distinct glycolytic and lipid oxidative metabolic programs are essential for effector and regulatory CD4+ T cell subsets. Journal of Immunology (Baltimore, Md. : 1950). 186: 3299-303. PMID 21317389 DOI: 10.4049/jimmunol.1003613  1
2011 Wang X, Eno CO, Altman BJ, Zhu Y, Zhao G, Olberding KE, Rathmell JC, Li C. ER stress modulates cellular metabolism. The Biochemical Journal. 435: 285-96. PMID 21241252 DOI: 10.1042/BJ20101864  0.92
2011 Coloff JL, Mason EF, Altman BJ, Gerriets VA, Liu T, Nichols AN, Zhao Y, Wofford JA, Jacobs SR, Ilkayeva O, Garrison SP, Zambetti GP, Rathmell JC. Akt requires glucose metabolism to suppress puma expression and prevent apoptosis of leukemic T cells. The Journal of Biological Chemistry. 286: 5921-33. PMID 21159778 DOI: 10.1074/jbc.M110.179101  1
2011 Altman BJ, Jacobs SR, Mason EF, Michalek RD, MacIntyre AN, Coloff JL, Ilkayeva O, Jia W, He YW, Rathmell JC. Autophagy is essential to suppress cell stress and to allow BCR-Abl-mediated leukemogenesis. Oncogene. 30: 1855-67. PMID 21151168 DOI: 10.1038/onc.2010.561  1
2011 Mason EF, Rathmell JC. Cell metabolism: an essential link between cell growth and apoptosis. Biochimica Et Biophysica Acta. 1813: 645-54. PMID 20816705 DOI: 10.1016/j.bbamcr.2010.08.011  1
2010 Mason EF, Zhao Y, Goraksha-Hicks P, Coloff JL, Gannon H, Jones SN, Rathmell JC. Aerobic glycolysis suppresses p53 activity to provide selective protection from apoptosis upon loss of growth signals or inhibition of BCR-Abl. Cancer Research. 70: 8066-76. PMID 20876800 DOI: 10.1158/0008-5472.CAN-10-0608  1
2010 Michalek RD, Rathmell JC. The metabolic life and times of a T-cell. Immunological Reviews. 236: 190-202. PMID 20636818 DOI: 10.1111/j.1600-065X.2010.00911.x  0.44
2010 Ke H, Harris R, Coloff JL, Jin JY, Leshin B, Miliani de Marval P, Tao S, Rathmell JC, Hall RP, Zhang JY. The c-Jun NH2-terminal kinase 2 plays a dominant role in human epidermal neoplasia. Cancer Research. 70: 3080-8. PMID 20354187 DOI: 10.1158/0008-5472.CAN-09-2923  1
2010 Jacobs SR, Michalek RD, Rathmell JC. IL-7 is essential for homeostatic control of T cell metabolism in vivo. Journal of Immunology (Baltimore, Md. : 1950). 184: 3461-9. PMID 20194717 DOI: 10.4049/jimmunol.0902593  1
2010 Calamito M, Juntilla MM, Thomas M, Northrup DL, Rathmell J, Birnbaum MJ, Koretzky G, Allman D. Akt1 and Akt2 promote peripheral B-cell maturation and survival. Blood. 115: 4043-50. PMID 20042722 DOI: 10.1182/blood-2009-09-241638  1
2009 Goraksha-Hicks P, Rathmell JC. TGF-beta: a new role for an old AktTOR. Developmental Cell. 17: 6-8. PMID 19619487 DOI: 10.1016/j.devcel.2009.07.004  0.6
2009 Altman BJ, Rathmell JC. Autophagy: not good OR bad, but good AND bad. Autophagy. 5: 569-70. PMID 19398886  0.92
2009 Altman BJ, Wofford JA, Zhao Y, Coloff JL, Ferguson EC, Wieman HL, Day AE, Ilkayeva O, Rathmell JC. Autophagy provides nutrients but can lead to Chop-dependent induction of Bim to sensitize growth factor-deprived cells to apoptosis. Molecular Biology of the Cell. 20: 1180-91. PMID 19109422 DOI: 10.1091/mbc.E08-08-0829  1
2009 Wardell SE, Ilkayeva OR, Wieman HL, Frigo DE, Rathmell JC, Newgard CB, McDonnell DP. Glucose metabolism as a target of histone deacetylase inhibitors. Molecular Endocrinology (Baltimore, Md.). 23: 388-401. PMID 19106193 DOI: 10.1210/me.2008-0179  1
2009 Wieman HL, Horn SR, Jacobs SR, Altman BJ, Kornbluth S, Rathmell JC. An essential role for the Glut1 PDZ-binding motif in growth factor regulation of Glut1 degradation and trafficking. The Biochemical Journal. 418: 345-67. PMID 19016655 DOI: 10.1042/BJ20081422  1
2008 Zhao Y, Coloff JL, Ferguson EC, Jacobs SR, Cui K, Rathmell JC. Glucose metabolism attenuates p53 and Puma-dependent cell death upon growth factor deprivation Journal of Biological Chemistry. 283: 36344-36353. PMID 18990690 DOI: 10.1074/jbc.M803580200  1
2008 Michalek RD, Rathmell JC. Methed-up FOXOs can't in-Akt-ivate. Molecular Cell. 32: 160-2. PMID 18951081 DOI: 10.1016/j.molcel.2008.10.006  0.44
2008 Zhao Y, Wieman HL, Jacobs SR, Rathmell JC. Chapter Twenty-Two Mechanisms and Methods in Glucose Metabolism and Cell Death Methods in Enzymology. 442: 439-457. PMID 18662583 DOI: 10.1016/S0076-6879(08)01422-5  1
2008 Ferguson EC, Rathmell JC. New roles for pyruvate kinase M2: working out the Warburg effect. Trends in Biochemical Sciences. 33: 359-62. PMID 18603432 DOI: 10.1016/j.tibs.2008.05.006  0.6
2008 MacIver NJ, Jacobs SR, Wieman HL, Wofford JA, Coloff JL, Rathmell JC. Glucose metabolism in lymphocytes is a regulated process with significant effects on immune cell function and survival Journal of Leukocyte Biology. 84: 949-957. PMID 18577716 DOI: 10.1189/jlb.0108024  1
2008 Jacobs SR, Herman CE, MacIver NJ, Wofford JA, Wieman HL, Hammen JJ, Rathmell JC. Glucose uptake is limiting in T cell activation and requires CD28-mediated akt-dependent and independent pathways Journal of Immunology. 180: 4476-4486. PMID 18354169  1
2008 Wofford JA, Wieman HL, Jacobs SR, Zhao Y, Rathmell JC. IL-7 promotes Glut1 trafficking and glucose uptake via STAT5-mediated activation of Akt to support T-cell survival Blood. 111: 2101-2111. PMID 18042802 DOI: 10.1182/blood-2007-06-096297  1
2007 Juntilla MM, Wofford JA, Birnbaum MJ, Rathmell JC, Koretzky GA. Akt1 and Akt2 are required for alphabeta thymocyte survival and differentiation. Proceedings of the National Academy of Sciences of the United States of America. 104: 12105-10. PMID 17609365 DOI: 10.1073/pnas.0705285104  1
2007 Rathmell JC, Kornbluth S. Filling a GAP(DH) in caspase-independent cell death. Cell. 129: 861-3. PMID 17540167 DOI: 10.1016/j.cell.2007.05.030  1
2007 Zhao Y, Altman BJ, Coloff JL, Herman CE, Jacobs SR, Wieman HL, Wofford JA, Dimascio LN, Ilkayeva O, Kelekar A, Reya T, Rathmell JC. Glycogen synthase kinase 3alpha and 3beta mediate a glucose-sensitive antiapoptotic signaling pathway to stabilize Mcl-1. Molecular and Cellular Biology. 27: 4328-39. PMID 17371841 DOI: 10.1128/MCB.00153-07  1
2007 Wieman HL, Wofford JA, Rathmell JC. Cytokine stimulation promotes glucose uptake via phosphatidylinositol-3 kinase/Akt regulation of Glut1 activity and trafficking. Molecular Biology of the Cell. 18: 1437-46. PMID 17301289 DOI: 10.1091/mbc.E06-07-0593  1
2006 Coloff JL, Rathmell JC. Metabolic regulation of Akt: roles reversed. The Journal of Cell Biology. 175: 845-7. PMID 17158959 DOI: 10.1083/jcb.200610119  0.88
2006 Boxer RB, Stairs DB, Dugan KD, Notarfrancesco KL, Portocarrero CP, Keister BA, Belka GK, Cho H, Rathmell JC, Thompson CB, Birnbaum MJ, Chodosh LA. Isoform-specific requirement for Akt1 in the developmental regulation of cellular metabolism during lactation. Cell Metabolism. 4: 475-90. PMID 17141631 DOI: 10.1016/j.cmet.2006.10.011  1
2006 Jacobs SR, Rathmell JC. Lymphocyte selection by starvation: Glucose metabolism and cell death Trends in Immunology. 27: 4-7. PMID 16300996 DOI: 10.1016/j.it.2005.11.002  1
2005 Nutt LK, Margolis SS, Jensen M, Herman CE, Dunphy WG, Rathmell JC, Kornbluth S. Metabolic regulation of oocyte cell death through the CaMKII-mediated phosphorylation of caspase-2. Cell. 123: 89-103. PMID 16213215 DOI: 10.1016/j.cell.2005.07.032  1
2005 Cinalli RM, Herman CE, Lew BO, Wieman HL, Thompson CB, Rathmell JC. T cell homeostasis requires G protein-coupled receptor-mediated access to trophic signals that promote growth and inhibit chemotaxis. European Journal of Immunology. 35: 786-95. PMID 15719365 DOI: 10.1002/eji.200425729  1
2004 Bauer DE, Harris MH, Plas DR, Lum JJ, Hammerman PS, Rathmell JC, Riley JL, Thompson CB. Cytokine stimulation of aerobic glycolysis in hematopoietic cells exceeds proliferative demand. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 18: 1303-5. PMID 15180958 DOI: 10.1096/fj.03-1001fje  1
2004 Bensinger SJ, Walsh PT, Zhang J, Carroll M, Parsons R, Rathmell JC, Thompson CB, Burchill MA, Farrar MA, Turka LA. Distinct IL-2 receptor signaling pattern in CD4+CD25+ regulatory T cells. Journal of Immunology (Baltimore, Md. : 1950). 172: 5287-96. PMID 15100267  1
2003 Rathmell JC, Fox CJ, Plas DR, Hammerman PS, Cinalli RM, Thompson CB. Akt-directed glucose metabolism can prevent Bax conformation change and promote growth factor-independent survival. Molecular and Cellular Biology. 23: 7315-28. PMID 14517300 DOI: 10.1128/MCB.23.20.7315-7328.2003  1
2003 Rathmell JC, Elstrom RL, Cinalli RM, Thompson CB. Activated Akt promotes increased resting T cell size, CD28-independent T cell growth, and development of autoimmunity and lymphoma. European Journal of Immunology. 33: 2223-32. PMID 12884297 DOI: 10.1002/eji.200324048  1
2002 Rathmell JC, Lindsten T, Zong WX, Cinalli RM, Thompson CB. Deficiency in Bak and Bax perturbs thymic selection and lymphoid homeostasis. Nature Immunology. 3: 932-9. PMID 12244308 DOI: 10.1038/ni834  1
2002 Frauwirth KA, Riley JL, Harris MH, Parry RV, Rathmell JC, Plas DR, Elstrom RL, June CH, Thompson CB. The CD28 signaling pathway regulates glucose metabolism. Immunity. 16: 769-77. PMID 12121659 DOI: 10.1016/S1074-7613(02)00323-0  1
2002 Plas DR, Rathmell JC, Thompson CB. Homeostatic control of lymphocyte survival: potential origins and implications. Nature Immunology. 3: 515-21. PMID 12032565 DOI: 10.1038/ni0602-515  1
2002 Rathmell JC, Thompson CB. Pathways of apoptosis in lymphocyte development, homeostasis, and disease. Cell. 109: S97-107. PMID 11983156 DOI: 10.1016/S0092-8674(02)00704-3  1
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