| Year |
Citation |
Score |
| 2024 |
Nadel G, Yao Z, Hacohen-Lev-Ran A, Wainstein E, Maik-Rachline G, Ziv T, Naor Z, Admon A, Seger R. Phosphorylation of PP2Ac by PKC is a key regulatory step in the PP2A-switch-dependent AKT dephosphorylation that leads to apoptosis. Cell Communication and Signaling : Ccs. 22: 154. PMID 38419089 DOI: 10.1186/s12964-024-01536-7 |
0.421 |
|
| 2023 |
Nadel G, Maik-Rachline G, Seger R. JNK Cascade-Induced Apoptosis-A Unique Role in GqPCR Signaling. International Journal of Molecular Sciences. 24. PMID 37686335 DOI: 10.3390/ijms241713527 |
0.519 |
|
| 2023 |
Seger R, Hanoch T, Rosenberg R, Dantes A, Merz WE, Strauss JF, Amsterdam A. The ERK Signaling Cascade Inhibits Gonadotropin-Stimulated Steroidogenesis. Journal of Biotechnology and Biomedicine. 6: 1-12. PMID 36970578 DOI: 10.26502/jbb.2642-91280066 |
0.535 |
|
| 2022 |
Hacohen Lev-Ran A, Seger R. Retention of ERK in the cytoplasm mediates the pluripotency of embryonic stem cells. Stem Cell Reports. 18: 305-318. PMID 36563690 DOI: 10.1016/j.stemcr.2022.11.017 |
0.397 |
|
| 2022 |
Wainstein E, Maik-Rachline G, Blenis J, Seger R. AKTs do not translocate to the nucleus upon stimulation but AKT3 can constitutively signal from the nuclear envelope. Cell Reports. 41: 111733. PMID 36476861 DOI: 10.1016/j.celrep.2022.111733 |
0.507 |
|
| 2022 |
Yung Y, Yao Z, Hanoch T, Seger R. ERK1b, a 46-kDa ERK Isoform That Is Differentially Regulated by MEK. Cell Biology International. PMID 35332606 DOI: 10.1002/cbin.11801 |
0.5 |
|
| 2022 |
Nadel G, Yao Z, Wainstein E, Cohen I, Ben-Ami I, Schajnovitz A, Maik-Rachline G, Naor Z, Horwitz BA, Seger R. GqPCR-stimulated dephosphorylation of AKT is induced by an IGBP1-mediated PP2A switch. Cell Communication and Signaling : Ccs. 20: 5. PMID 34998390 DOI: 10.1186/s12964-021-00805-z |
0.708 |
|
| 2021 |
Maik-Rachline G, Wortzel I, Seger R. Alternative Splicing of MAPKs in the Regulation of Signaling Specificity. Cells. 10. PMID 34943973 DOI: 10.3390/cells10123466 |
0.463 |
|
| 2021 |
Wortzel I, Maik-Rachline G, Yadav SS, Hanoch T, Seger R. Mitotic HOOK3 phosphorylation by ERK1c drives microtubule-dependent Golgi destabilization and fragmentation. Iscience. 24: 102670. PMID 34189435 DOI: 10.1016/j.isci.2021.102670 |
0.373 |
|
| 2020 |
Kraus S, Benard O, Naor Z, Seger R. C-Src is Activated by the EGF Receptor in a Pathway that Mediates JNK and ERK Activation by Gonadotropin-Releasing Hormone in COS7 Cells. International Journal of Molecular Sciences. 21. PMID 33202981 DOI: 10.3390/ijms21228575 |
0.469 |
|
| 2020 |
Maik-Rachline G, Lifshits L, Seger R. Nuclear P38: Roles in Physiological and Pathological Processes and Regulation of Nuclear Translocation. International Journal of Molecular Sciences. 21. PMID 32847129 DOI: 10.3390/Ijms21176102 |
0.465 |
|
| 2020 |
Weidner P, Söhn M, Schroeder T, Helm L, Hauber V, Gutting T, Betge J, Röcken C, Rohrbacher FN, Pattabiraman VR, Bode JW, Seger R, Saar D, Nunes-Alves A, Wade RC, et al. Myotubularin-related protein 7 activates peroxisome proliferator-activated receptor-gamma. Oncogenesis. 9: 59. PMID 32522977 DOI: 10.1038/s41389-020-0238-8 |
0.435 |
|
| 2020 |
Chuderland D, Marmor G, Shainskaya A, Seger R. Calcium-Mediated Interactions Regulate the Subcellular Localization of Extracellular Signal-Regulated Kinases (ERKs). Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology. 54: 474-492. PMID 32392404 DOI: 10.33594/000000231 |
0.798 |
|
| 2019 |
Plotnikov A, Chuderland D, Karamansha Y, Livnah O, Seger R. Nuclear ERK Translocation is Mediated by Protein Kinase CK2 and Accelerated by Autophosphorylation. Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology. 53: 366-387. PMID 31385665 DOI: 10.33594/000000144 |
0.823 |
|
| 2019 |
Zehorai E, Seger R. Beta-Like Importins Mediate the Nuclear Translocation of MAPKs. Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology. 52: 802-821. PMID 30946556 DOI: 10.33594/000000056 |
0.438 |
|
| 2019 |
Arafeh R, Flores K, Keren-Paz A, Maik-Rachline G, Gutkind N, Rosenberg S, Seger R, Samuels Y. Author Correction: Combined inhibition of MEK and nuclear ERK translocation has synergistic antitumor activity in melanoma cells. Scientific Reports. 9: 4672. PMID 30858388 DOI: 10.1038/S41598-018-37931-7 |
0.339 |
|
| 2019 |
Maik-Rachline G, Hacohen-Lev-Ran A, Seger R. Nuclear ERK: Mechanism of Translocation, Substrates, and Role in Cancer. International Journal of Molecular Sciences. 20. PMID 30857244 DOI: 10.3390/Ijms20051194 |
0.531 |
|
| 2019 |
Mugami S, Kravchook S, Rahamim-Ben Navi L, Seger R, Naor Z. Corrigendum to differential roles of PKC isoforms (PKCs) and Ca in GnRH and phorbol 12-myristate 13-acetate (PMA) stimulation of p38MAPK phosphorylation in immortalized gonadotrope cells. [Mol Cell Endocrinol 439: 141-154 (2017)]. Molecular and Cellular Endocrinology. 482: 81. PMID 30639051 DOI: 10.1016/J.Mce.2018.12.018 |
0.441 |
|
| 2018 |
Nadel G, Yao Z, Ben-Ami I, Naor Z, Seger R. Gq-Induced Apoptosis is Mediated by AKT Inhibition That Leads to PKC-Induced JNK Activation. Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology. 50: 121-135. PMID 30278445 DOI: 10.1159/000493963 |
0.738 |
|
| 2018 |
Flores K, Katz AA, Yadav SS, Seger R. The nuclear translocation of mitogen-activated protein kinases: molecular mechanisms and use as novel therapeutic target. Neuroendocrinology. PMID 30261516 DOI: 10.1159/000494085 |
0.477 |
|
| 2018 |
Konson A, Pradeep S, D'Acunto CW, Seger R. Pigment Epithelium-Derived Factor and its Phosphomimetic Mutant Induce JNK-Dependent Apoptosis and P38-Mediated Migration Arrest. Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology. 49: 512-529. PMID 30157491 DOI: 10.1159/000492990 |
0.417 |
|
| 2018 |
Ordan M, Pallara C, Maik-Rachline G, Hanoch T, Gervasio FL, Glaser F, Fernandez-Recio J, Seger R. Intrinsically active MEK variants are differentially regulated by proteinases and phosphatases. Scientific Reports. 8: 11830. PMID 30087384 DOI: 10.1038/S41598-018-30202-5 |
0.485 |
|
| 2018 |
Plotnikov A, Chuderland D, Karamansha Y, Livnah O, Seger R. Retraction for Plotnikov et al., "Nuclear Extracellular Signal-Regulated Kinase 1 and 2 Translocation Is Mediated by Casein Kinase 2 and Accelerated by Autophosphorylation". Molecular and Cellular Biology. 38. PMID 29764996 DOI: 10.1128/Mcb.00106-18 |
0.779 |
|
| 2018 |
Zehorai E, Seger R. Retraction for Zehorai and Seger, "Beta-Like Importins Mediate the Nuclear Translocation of Mitogen-Activated Protein Kinases". Molecular and Cellular Biology. 38. PMID 29764995 DOI: 10.1128/MCB.00105-18 |
0.402 |
|
| 2018 |
Maik-Rachline G, Zehorai E, Hanoch T, Blenis J, Seger R. The nuclear translocation of the kinases p38 and JNK promotes inflammation-induced cancer. Science Signaling. 11. PMID 29636389 DOI: 10.1126/Scisignal.Aao3428 |
0.398 |
|
| 2018 |
Weidner P, Söhn M, Gutting T, Friedrich T, Seger R, Ebert M, Burgermeister E. Myotubularin-Related Protein 7: zytosolischer Bindepartner und positiver Regulator der PPARgamma-Aktivität durch Inhibition der RAS-abhängigen Signalkaskade im Kolorektalen Karzinom Zeitschrift FüR Gastroenterologie. 56: e294-e294. DOI: 10.1055/S-0038-1668900 |
0.333 |
|
| 2017 |
Arafeh R, Flores K, Keren-Paz A, Maik-Rachline G, Gutkind N, Rosenberg S, Seger R, Samuels Y. Combined inhibition of MEK and nuclear ERK translocation has synergistic antitumor activity in melanoma cells. Scientific Reports. 7: 16345. PMID 29180761 DOI: 10.1038/S41598-017-16558-0 |
0.45 |
|
| 2017 |
Kapri-Pardes E, Hanoch T, Maik-Rachline G, Murbach M, Bounds PL, Kuster N, Seger R. Activation of Signaling Cascades by Weak Extremely Low Frequency Electromagnetic Fields. Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology. 43: 1. PMID 29035881 DOI: 10.1159/000481977 |
0.564 |
|
| 2017 |
Birkner K, Wasser B, Loos J, Plotnikov A, Seger R, Zipp F, Witsch E, Bittner S. The Role of ERK Signaling in Experimental Autoimmune Encephalomyelitis. International Journal of Molecular Sciences. 18. PMID 28914804 DOI: 10.3390/Ijms18091990 |
0.544 |
|
| 2017 |
Aebersold DM, Shaul YD, Yung Y, Yarom N, Yao Z, Hanoch T, Seger R. Correction for Aebersold et al., "Extracellular Signal-Regulated Kinase 1c (ERK1c), a Novel 42-Kilodalton ERK, Demonstrates Unique Modes of Regulation, Localization, and Function". Molecular and Cellular Biology. 37. PMID 28847972 DOI: 10.1128/Mcb.00322-17 |
0.462 |
|
| 2017 |
Zehorai E, Seger R. Correction for Zehorai and Seger, "Beta-Like Importins Mediate the Nuclear Translocation of Mitogen-Activated Protein Kinases". Molecular and Cellular Biology. 37. PMID 28754769 DOI: 10.1128/Mcb.00215-17 |
0.494 |
|
| 2017 |
Rahamim-Ben Navi L, Tsukerman A, Feldman A, Melamed P, Tomić M, Stojilkovic SS, Boehm U, Seger R, Naor Z. GnRH Induces ERK-Dependent Bleb Formation in Gonadotrope Cells, Involving Recruitment of Members of a GnRH Receptor-Associated Signalosome to the Blebs. Frontiers in Endocrinology. 8: 113. PMID 28626446 DOI: 10.3389/Fendo.2017.00113 |
0.54 |
|
| 2017 |
Benard O, Naor Z, Seger R. Role of dynamin, Src, and Ras in the protein kinase C-mediated activation of ERK by gonadotropin-releasing hormone. The Journal of Biological Chemistry. 292: 8855. PMID 28550141 DOI: 10.1074/Jbc.M006995200 |
0.594 |
|
| 2017 |
Yung Y, Yao Z, Hanoch T, Seger R. ERK1b, a 46-kDa ERK isoform that is differentially regulated by MEK. The Journal of Biological Chemistry. 292: 8854. PMID 28550140 DOI: 10.1074/Jbc.M910060199 |
0.52 |
|
| 2017 |
Wolf I, Rubinfeld H, Yoon S, Marmor G, Hanoch T, Seger R. Involvement of the activation loop of ERK in the detachment from cytosolic anchoring. The Journal of Biological Chemistry. 292: 8853. PMID 28550139 DOI: 10.1074/Jbc.M103352200 |
0.535 |
|
| 2017 |
Yung Y, Yao Z, Aebersold DM, Hanoch T, Seger R. Altered regulation of ERK1b by MEK1 and PTP-SL and modified Elk1 phosphorylation by ERK1b are caused by abrogation of the regulatory C-terminal sequence of ERKs. The Journal of Biological Chemistry. 292: 8852. PMID 28550138 DOI: 10.1074/Jbc.M105995200 |
0.581 |
|
| 2017 |
Kraus S, Benard O, Naor Z, Seger R. c-Src is activated by the epidermal growth factor receptor in a pathway that mediates JNK and ERK activation by gonadotropin-releasing hormone in COS7 cells. The Journal of Biological Chemistry. 292: 8851. PMID 28550137 DOI: 10.1074/jbc.A117.303886 |
0.356 |
|
| 2017 |
Chuderland D, Marmor G, Shainskaya A, Seger R. Calcium-mediated interactions regulate the subcellular localization of extracellular signal-regulated kinases. The Journal of Biological Chemistry. 292: 8850. PMID 28550136 DOI: 10.1074/Jbc.A117.709030 |
0.771 |
|
| 2017 |
Ben-Ami I, Yao Z, Naor Z, Seger R. Gq protein-induced apoptosis is mediated by AKT kinase inhibition that leads to protein kinase C-induced c-Jun N-terminal kinase activation. The Journal of Biological Chemistry. 292: 8848. PMID 28550134 DOI: 10.1074/jbc.A111.247726 |
0.719 |
|
| 2017 |
Seger R, Hanoch T, Rosenberg R, Dantes A, Merz WE, Strauss JF, Amsterdam A. The ERK signaling cascade inhibits gonadotropin-stimulated steroidogenesis. The Journal of Biological Chemistry. 292: 8847. PMID 28550133 DOI: 10.1074/Jbc.M006852200 |
0.609 |
|
| 2017 |
Procaccia S, Ordan M, Cohen I, Bendetz-Nezer S, Seger R. Direct binding of MEK1 and MEK2 to AKT induces Foxo1 phosphorylation, cellular migration and metastasis. Scientific Reports. 7: 43078. PMID 28225038 DOI: 10.1038/Srep43078 |
0.526 |
|
| 2017 |
Berti DA, Seger R. The Nuclear Translocation of ERK. Methods in Molecular Biology (Clifton, N.J.). 1487: 175-194. PMID 27924567 DOI: 10.1007/978-1-4939-6424-6_13 |
0.632 |
|
| 2017 |
Weidner P, Söhn M, Gutting T, Gaiser T, Kienle P, Magdeburg J, Röcken C, Hopf C, Seger R, Ebert M, Burgermeister E. Myotubularin Related Protein 7 – ein dualer Ras- und mTORC-Inhibitor im kolorektalen Karzinom Viszeralmedizin. DOI: 10.1055/S-0037-1604734 |
0.308 |
|
| 2016 |
Rahamim Ben-Navi L, Almog T, Yao Z, Seger R, Naor Z. A-Kinase Anchoring Protein 4 (AKAP4) is an ERK1/2 substrate and a switch molecule between cAMP/PKA and PKC/ERK1/2 in human spermatozoa. Scientific Reports. 6: 37922. PMID 27901058 DOI: 10.1038/Srep37922 |
0.552 |
|
| 2016 |
Mugami S, Kravchook S, Navi LR, Seger R, Naor Z. Differential roles of PKC isoforms (PKCs) and Ca(2+) in GnRH and phorbol 12-myristate 13-acetate (PMA) stimulation of p38MAPK phosphorylation in immortalized gonadotrope cells. Molecular and Cellular Endocrinology. PMID 27810601 DOI: 10.1016/J.Mce.2016.10.031 |
0.473 |
|
| 2016 |
Weidner P, Söhn M, Gutting T, Friedrich T, Gaiser T, Magdeburg J, Kienle P, Ruh H, Hopf C, Behrens HM, Röcken C, Hanoch T, Seger R, Ebert MP, Burgermeister E. Myotubularin-related protein 7 inhibits insulin signaling in colorectal cancer. Oncotarget. PMID 27409167 DOI: 10.18632/Oncotarget.10466 |
0.361 |
|
| 2016 |
Maik-Rachline G, Seger R. The ERK cascade inhibitors: Towards overcoming resistance. Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy. 25: 1-12. PMID 27155372 DOI: 10.1016/J.Drup.2015.12.001 |
0.357 |
|
| 2016 |
Visochek L, Grigoryan G, Kalal A, Milshtein-Parush H, Gazit N, Slutsky I, Yeheskel A, Shainberg A, Castiel A, Seger R, Langelier MF, Dantzer F, Pascal JM, Segal M, Cohen-Armon M. A PARP1-ERK2 synergism is required for the induction of LTP. Scientific Reports. 6: 24950. PMID 27121568 DOI: 10.1038/Srep24950 |
0.415 |
|
| 2016 |
Wainstein E, Seger R. The dynamic subcellular localization of ERK: mechanisms of translocation and role in various organelles. Current Opinion in Cell Biology. 39: 15-20. PMID 26827288 DOI: 10.1016/J.Ceb.2016.01.007 |
0.501 |
|
| 2015 |
Oren M, Damalas A, Gottlieb T, Michael D, Taplick J, Martinez Leal JF, Maya R, Moas M, Seger R, Taya Y, Ben-Ze'ev A. Retraction notice to "Regulation of p53: Intricate loops and delicate balances" [Biochem. Pharmacol. 64 (2002) 865-871]. Biochemical Pharmacology. 96: 369. PMID 26465018 DOI: 10.1016/J.Bcp.2015.07.001 |
0.315 |
|
| 2015 |
Wortzel I, Hanoch T, Porat Z, Hausser A, Seger R. Mitotic Golgi translocation of ERK1c is mediated by a PI4KIIIβ-14-3-3γ shuttling complex. Journal of Cell Science. 128: 4083-95. PMID 26459638 DOI: 10.1242/Jcs.170910 |
0.485 |
|
| 2015 |
Bar-Lev TH, Harris D, Tomić M, Stojilkovic S, Blumenfeld Z, Brown P, Seger R, Naor Z. Role of PI4K and PI3K-AKT in ERK1/2 activation by GnRH in the pituitary gonadotropes. Molecular and Cellular Endocrinology. 415: 12-23. PMID 26238084 DOI: 10.1016/J.Mce.2015.07.029 |
0.547 |
|
| 2015 |
Schevzov G, Kee AJ, Wang B, Sequeira VB, Hook J, Coombes JD, Lucas CA, Stehn JR, Musgrove EA, Cretu A, Assoian R, Fath T, Hanoch T, Seger R, Pleines I, et al. Regulation of cell proliferation by ERK and signal-dependent nuclear translocation of ERK is dependent on Tm5NM1-containing actin filaments. Molecular Biology of the Cell. 26: 2475-90. PMID 25971798 DOI: 10.1091/Mbc.E14-10-1453 |
0.55 |
|
| 2015 |
Malach E, Shaul ME, Peri I, Huang L, Spielman AI, Seger R, Naim M. Membrane-permeable tastants amplify β2-adrenergic receptor signaling and delay receptor desensitization via intracellular inhibition of GRK2's kinase activity. Biochimica Et Biophysica Acta. 1850: 1375-88. PMID 25857770 DOI: 10.1016/J.Bbagen.2015.03.015 |
0.485 |
|
| 2015 |
Plotnikov A, Flores K, Maik-Rachline G, Zehorai E, Kapri-Pardes E, Berti DA, Hanoch T, Besser MJ, Seger R. The nuclear translocation of ERK1/2 as an anticancer target. Nature Communications. 6: 6685. PMID 25819065 DOI: 10.1038/Ncomms7685 |
0.431 |
|
| 2014 |
Amsterdam A, Shpigner L, Raanan C, Schreiber L, Melzer E, Seger R. Dynamic distribution of ERK, p38 and JNK during the development of pancreatic ductal adenocarcinoma. Acta Histochemica. 116: 1434-42. PMID 25440531 DOI: 10.1016/J.Acthis.2014.09.007 |
0.443 |
|
| 2014 |
Michailovici I, Harrington HA, Azogui HH, Yahalom-Ronen Y, Plotnikov A, Ching S, Stumpf MPH, Klein OD, Seger R, Tzahor E. Nuclear to cytoplasmic shuttling of ERK promotes differentiation of muscle stem/progenitor cells Development (Cambridge). 141: 2611-2620. PMID 24924195 DOI: 10.1242/Dev.107078 |
0.469 |
|
| 2014 |
Zehorai E, Seger R. Beta-like importins mediate the nuclear translocation of mitogen-activated protein kinases. Molecular and Cellular Biology. 34: 259-70. PMID 24216760 DOI: 10.1128/Mcb.00799-13 |
0.579 |
|
| 2013 |
Futran AS, Link AJ, Seger R, Shvartsman SY. ERK as a model for systems biology of enzyme kinetics in cells. Current Biology : Cb. 23: R972-9. PMID 24200329 DOI: 10.1016/J.Cub.2013.09.033 |
0.318 |
|
| 2013 |
Flores K, Seger R. Stimulated nuclear import by β-like importins. F1000prime Reports. 5: 41. PMID 24167722 DOI: 10.12703/P5-41 |
0.387 |
|
| 2013 |
Bar-Gill AB, Efergan A, Seger R, Fukuda M, Sagi-Eisenberg R. The extra-cellular signal regulated kinases ERK1 and ERK2 segregate displaying distinct spatiotemporal characteristics in activated mast cells. Biochimica Et Biophysica Acta. 1833: 2070-82. PMID 23651922 DOI: 10.1016/J.Bbamcr.2013.04.016 |
0.62 |
|
| 2013 |
Sviridonov L, Dobkin-Bekman M, Shterntal B, Przedecki F, Formishell L, Kravchook S, Rahamim-Ben Navi L, Bar-Lev TH, Kazanietz MG, Yao Z, Seger R, Naor Z. Differential signaling of the GnRH receptor in pituitary gonadotrope cell lines and prostate cancer cell lines. Molecular and Cellular Endocrinology. 369: 107-18. PMID 23380421 DOI: 10.1016/J.Mce.2013.01.010 |
0.328 |
|
| 2012 |
Casar B, Rodríguez J, Gibor G, Seger R, Crespo P. Mxi2 sustains ERK1/2 phosphorylation in the nucleus by preventing ERK1/2 binding to phosphatases. The Biochemical Journal. 441: 571-8. PMID 21950314 DOI: 10.1042/Bj20110870 |
0.616 |
|
| 2011 |
Wortzel I, Seger R. The ERK Cascade: Distinct Functions within Various Subcellular Organelles. Genes & Cancer. 2: 195-209. PMID 21779493 DOI: 10.1177/1947601911407328 |
0.555 |
|
| 2011 |
Ben-Ami I, Yao Z, Naor Z, Seger R. Gq protein-induced apoptosis is mediated by AKT kinase inhibition that leads to protein kinase C-induced c-Jun N-terminal kinase activation. The Journal of Biological Chemistry. 286: 31022-31. PMID 21757743 DOI: 10.1074/Jbc.M111.247726 |
0.745 |
|
| 2011 |
Plotnikov A, Chuderland D, Karamansha Y, Livnah O, Seger R. Nuclear extracellular signal-regulated kinase 1 and 2 translocation is mediated by casein kinase 2 and accelerated by autophosphorylation. Molecular and Cellular Biology. 31: 3515-30. PMID 21730285 DOI: 10.1128/Mcb.05424-11 |
0.823 |
|
| 2011 |
Burgermeister E, Friedrich T, Hitkova I, Regel I, Einwächter H, Zimmermann W, Röcken C, Perren A, Wright MB, Schmid RM, Seger R, Ebert MP. The Ras inhibitors caveolin-1 and docking protein 1 activate peroxisome proliferator-activated receptor γ through spatial relocalization at helix 7 of its ligand-binding domain. Molecular and Cellular Biology. 31: 3497-510. PMID 21690289 DOI: 10.1128/Mcb.01421-10 |
0.457 |
|
| 2011 |
Amsterdam A, Shezen E, Raanan C, Schreiber L, Prus D, Slilat Y, Ben-Arie A, Seger R. Nuclear localization of phosphorylated ERK1 and ERK2 as markers for the progression of ovarian cancer. International Journal of Oncology. 39: 649-56. PMID 21687944 DOI: 10.3892/Ijo.2011.1090 |
0.303 |
|
| 2011 |
Schajnovitz A, Itkin T, D'Uva G, Kalinkovich A, Golan K, Ludin A, Cohen D, Shulman Z, Avigdor A, Nagler A, Kollet O, Seger R, Lapidot T. CXCL12 secretion by bone marrow stromal cells is dependent on cell contact and mediated by connexin-43 and connexin-45 gap junctions. Nature Immunology. 12: 391-8. PMID 21441933 DOI: 10.1038/Ni.2017 |
0.385 |
|
| 2011 |
Plotnikov A, Zehorai E, Procaccia S, Seger R. The MAPK cascades: signaling components, nuclear roles and mechanisms of nuclear translocation. Biochimica Et Biophysica Acta. 1813: 1619-33. PMID 21167873 DOI: 10.1016/J.Bbamcr.2010.12.012 |
0.488 |
|
| 2011 |
Konson A, Pradeep S, D'Acunto CW, Seger R. Pigment epithelium-derived factor and its phosphomimetic mutant induce JNK-dependent apoptosis and p38-mediated migration arrest. The Journal of Biological Chemistry. 286: 3540-51. PMID 21059648 DOI: 10.1074/Jbc.M110.151548 |
0.488 |
|
| 2010 |
Yao Z, Yoon S, Kalie E, Raviv Z, Seger R. Calcium regulation of EGF-induced ERK5 activation: role of Lad1-MEKK2 interaction. Plos One. 5: e12627. PMID 20830310 DOI: 10.1371/Journal.Pone.0012627 |
0.488 |
|
| 2010 |
Procaccia S, Kraus S, Seger R. Determination of ERK activity: anti-phospho-ERK antibodies and in vitro phosphorylation. Methods in Molecular Biology (Clifton, N.J.). 661: 39-58. PMID 20811975 DOI: 10.1007/978-1-60761-795-2_2 |
0.622 |
|
| 2010 |
Keshet Y, Seger R. The MAP kinase signaling cascades: a system of hundreds of components regulates a diverse array of physiological functions. Methods in Molecular Biology (Clifton, N.J.). 661: 3-38. PMID 20811974 DOI: 10.1007/978-1-60761-795-2_1 |
0.619 |
|
| 2010 |
Dobkin-Bekman M, Rahamin-Ben Navi L, Ben-Navi LR, Shterntal B, Sviridonov L, Przedecki F, Naidich-Exler M, Brodie C, Seger R, Naor Z. Differential role of PKC isoforms in GnRH and phorbol 12-myristate 13-acetate activation of extracellular signal-regulated kinase and Jun N-terminal kinase. Endocrinology. 151: 4894-907. PMID 20810567 DOI: 10.1210/En.2010-0114 |
0.572 |
|
| 2010 |
Tirosh-Finkel L, Zeisel A, Brodt-Ivenshitz M, Shamai A, Yao Z, Seger R, Domany E, Tzahor E. BMP-mediated inhibition of FGF signaling promotes cardiomyocyte differentiation of anterior heart field progenitors. Development (Cambridge, England). 137: 2989-3000. PMID 20702560 DOI: 10.1242/Jcs.079764 |
0.4 |
|
| 2010 |
Erster O, Seger R, Liscovitch M. Ligand interaction scan (LIScan) in the study of ERK8. Biochemical and Biophysical Research Communications. 399: 37-41. PMID 20638370 DOI: 10.1016/J.Bbrc.2010.07.029 |
0.53 |
|
| 2010 |
Konson A, Pradeep S, Seger R. Phosphomimetic mutants of pigment epithelium-derived factor with enhanced antiangiogenic activity as potent anticancer agents. Cancer Research. 70: 6247-57. PMID 20610633 DOI: 10.1158/0008-5472.Can-10-0434 |
0.322 |
|
| 2010 |
Reich-Zeliger S, Eidelstein Y, Hagin D, Antebi YE, Seger R, Reisner Y. Deletion of alloreactive T cells by veto cytotoxic T lymphocytes is mediated through extracellular signal-regulated kinase phosphorylation. Transplantation. 90: 380-6. PMID 20595932 DOI: 10.1097/Tp.0B013E3181E86B28 |
0.411 |
|
| 2010 |
Zehorai E, Yao Z, Plotnikov A, Seger R. The subcellular localization of MEK and ERK--a novel nuclear translocation signal (NTS) paves a way to the nucleus. Molecular and Cellular Endocrinology. 314: 213-20. PMID 19406201 DOI: 10.1016/J.Mce.2009.04.008 |
0.597 |
|
| 2009 |
Shaul YD, Gibor G, Plotnikov A, Seger R. Specific phosphorylation and activation of ERK1c by MEK1b: a unique route in the ERK cascade. Genes & Development. 23: 1779-90. PMID 19651986 DOI: 10.1101/Gad.523909 |
0.637 |
|
| 2009 |
Dobkin-Bekman M, Naidich M, Rahamim L, Przedecki F, Almog T, Lim S, Melamed P, Liu P, Wohland T, Yao Z, Seger R, Naor Z. A preformed signaling complex mediates GnRH-activated ERK phosphorylation of paxillin and FAK at focal adhesions in L beta T2 gonadotrope cells. Molecular Endocrinology (Baltimore, Md.). 23: 1850-64. PMID 19628583 DOI: 10.1210/Me.2008-0260 |
0.601 |
|
| 2009 |
Yao Z, Seger R. The ERK signaling cascade--views from different subcellular compartments. Biofactors (Oxford, England). 35: 407-16. PMID 19565474 DOI: 10.1002/Biof.52 |
0.509 |
|
| 2008 |
Chuderland D, Seger R. Calcium regulates ERK signaling by modulating its protein-protein interactions. Communicative & Integrative Biology. 1: 4-5. PMID 19704446 DOI: 10.4161/Cib.1.1.6107 |
0.776 |
|
| 2008 |
Chuderland D, Konson A, Seger R. Identification and characterization of a general nuclear translocation signal in signaling proteins. Molecular Cell. 31: 850-61. PMID 18760948 DOI: 10.1016/J.Molcel.2008.08.007 |
0.8 |
|
| 2008 |
Burgermeister E, Seger R. PPARgamma and MEK Interactions in Cancer. Ppar Research. 2008: 309469. PMID 18596912 DOI: 10.1155/2008/309469 |
0.547 |
|
| 2008 |
Corn BW, Kovner F, Bek S, Wexler I, Lifschits B, Seger R. ERK signaling in colorectal cancer: a preliminary report on the expression of phosphorylated ERK and the effects of radiation therapy. American Journal of Clinical Oncology. 31: 255-8. PMID 18525304 DOI: 10.1097/Coc.0B013E31815A5647 |
0.516 |
|
| 2008 |
Almog T, Lazar S, Reiss N, Etkovitz N, Milch E, Rahamim N, Dobkin-Bekman M, Rotem R, Kalina M, Ramon J, Raziel A, Breitbart H, Brietbart H, Seger R, Naor Z. Identification of extracellular signal-regulated kinase 1/2 and p38 MAPK as regulators of human sperm motility and acrosome reaction and as predictors of poor spermatozoan quality. The Journal of Biological Chemistry. 283: 14479-89. PMID 18372245 DOI: 10.1074/Jbc.M710492200 |
0.531 |
|
| 2008 |
Shaharabany M, Holtzman EJ, Mayan H, Hirschberg K, Seger R, Farfel Z. Distinct pathways for the involvement of WNK4 in the signaling of hypertonicity and EGF. The Febs Journal. 275: 1631-42. PMID 18312414 DOI: 10.1111/J.1742-4658.2008.06318.X |
0.584 |
|
| 2008 |
Chuderland D, Marmor G, Shainskaya A, Seger R. Calcium-mediated interactions regulate the subcellular localization of extracellular signal-regulated kinases. The Journal of Biological Chemistry. 283: 11176-88. PMID 18268018 DOI: 10.1074/jbc.M709030200 |
0.759 |
|
| 2008 |
Schajnovitz A, Itkin T, Ludin A, Kalinkovich A, Lapid K, Seger R, Lapidot T. Functional SDF-1 Secretion from BM Stromal Cells Is a Cell Contact-Dependent Event Mediated by Cx43 and Cx45 Gap-Junctions Blood. 112: 319-319. DOI: 10.1182/Blood.V112.11.319.319 |
0.365 |
|
| 2008 |
Seger R, Rodeck U, Yarden Y. Meeting report: Receptor tyrosine kinases: The emerging tip of systems control Iet Systems Biology. 2: 1-4. DOI: 10.1049/Iet-Syb:20070048 |
0.474 |
|
| 2007 |
Burgermeister E, Seger R. MAPK kinases as nucleo-cytoplasmic shuttles for PPARgamma. Cell Cycle (Georgetown, Tex.). 6: 1539-48. PMID 17611413 DOI: 10.4161/Cc.6.13.4453 |
0.598 |
|
| 2007 |
Bendetz-Nezer S, Seger R. Role of non-phosphorylated activation loop residues in determining ERK2 dephosphorylation, activity, and subcellular localization. The Journal of Biological Chemistry. 282: 25114-22. PMID 17597065 DOI: 10.1074/Jbc.M703120200 |
0.564 |
|
| 2007 |
Spector NL, Yarden Y, Smith B, Lyass L, Trusk P, Pry K, Hill JE, Xia W, Seger R, Bacus SS. Activation of AMP-activated protein kinase by human EGF receptor 2/EGF receptor tyrosine kinase inhibitor protects cardiac cells. Proceedings of the National Academy of Sciences of the United States of America. 104: 10607-12. PMID 17556544 DOI: 10.1073/Pnas.0701286104 |
0.489 |
|
| 2007 |
Friedman J, Kraus S, Hauptman Y, Schiff Y, Seger R. Mechanism of short-term ERK activation by electromagnetic fields at mobile phone frequencies. The Biochemical Journal. 405: 559-68. PMID 17456048 DOI: 10.1042/Bj20061653 |
0.562 |
|
| 2007 |
Cohen-Armon M, Visochek L, Rozensal D, Kalal A, Geistrikh I, Klein R, Bendetz-Nezer S, Yao Z, Seger R. DNA-independent PARP-1 activation by phosphorylated ERK2 increases Elk1 activity: a link to histone acetylation. Molecular Cell. 25: 297-308. PMID 17244536 DOI: 10.1016/J.Molcel.2006.12.012 |
0.545 |
|
| 2007 |
Shaul YD, Seger R. The MEK/ERK cascade: from signaling specificity to diverse functions. Biochimica Et Biophysica Acta. 1773: 1213-26. PMID 17112607 DOI: 10.1016/J.Bbamcr.2006.10.005 |
0.492 |
|
| 2007 |
Burgermeister E, Chuderland D, Hanoch T, Meyer M, Liscovitch M, Seger R. Interaction with MEK causes nuclear export and downregulation of peroxisome proliferator-activated receptor gamma. Molecular and Cellular Biology. 27: 803-17. PMID 17101779 DOI: 10.1128/Mcb.00601-06 |
0.822 |
|
| 2007 |
Bacus SS, Hill JE, Trusk P, Seger R, Spector NL. Activation of the AMPK regulated metabolic stress response by a small molecule HER2/EGFR tyrosine kinase inhibitor protects cardiac myocytes from apoptotic stimuli Journal of Clinical Oncology. 25: 14000-14000. DOI: 10.1200/JCO.2007.25.18_SUPPL.14000 |
0.401 |
|
| 2007 |
Reich-zeliger S, Edelshtein Y, Hagin D, Seger R, Reisner Y. The Role of ERK and XIAP in Tolerance Induction by Veto CTLs. Blood. 110: 3256-3256. DOI: 10.1182/Blood.V110.11.3256.3256 |
0.347 |
|
| 2006 |
Shaul Y, Seger R. The detection of MAPK signaling. Current Protocols in Molecular Biology / Edited by Frederick M. Ausubel ... [Et Al.]. Unit 18.12. PMID 18265377 DOI: 10.1002/0471142727.Mb1812S73 |
0.599 |
|
| 2006 |
Ben-David H, Aruna BV, Seger R, Sela M, Mozes E. A 50-kDa ERK-like protein is up-regulated by a dual altered peptide ligand that suppresses myasthenia gravis-associated responses Proceedings of the National Academy of Sciences of the United States of America. 103: 18232-18237. PMID 17108079 DOI: 10.1073/Pnas.0608896103 |
0.498 |
|
| 2006 |
Perlson E, Michaelevski I, Kowalsman N, Ben-Yaakov K, Shaked M, Seger R, Eisenstein M, Fainzilber M. Vimentin binding to phosphorylated Erk sterically hinders enzymatic dephosphorylation of the kinase. Journal of Molecular Biology. 364: 938-44. PMID 17046786 DOI: 10.1016/J.Jmb.2006.09.056 |
0.488 |
|
| 2006 |
Ben-Ami I, Freimann S, Armon L, Dantes A, Strassburger D, Friedler S, Raziel A, Seger R, Ron-El R, Amsterdam A. PGE2 up-regulates EGF-like growth factor biosynthesis in human granulosa cells: new insights into the coordination between PGE2 and LH in ovulation. Molecular Human Reproduction. 12: 593-9. PMID 16888076 DOI: 10.1093/Molehr/Gal068 |
0.662 |
|
| 2006 |
Dobkin-Bekman M, Naidich M, Pawson AJ, Millar RP, Seger R, Naor Z. Activation of mitogen-activated protein kinase (MAPK) by GnRH is cell-context dependent. Molecular and Cellular Endocrinology. 252: 184-90. PMID 16682115 DOI: 10.1016/J.Mce.2006.03.035 |
0.621 |
|
| 2006 |
Kraus S, Naor Z, Seger R. Gonadotropin-releasing hormone in apoptosis of prostate cancer cells. Cancer Letters. 234: 109-23. PMID 16546667 DOI: 10.1016/J.Canlet.2005.02.038 |
0.301 |
|
| 2006 |
Shaul YD, Seger R. ERK1c regulates Golgi fragmentation during mitosis. The Journal of Cell Biology. 172: 885-97. PMID 16533948 DOI: 10.1083/Jcb.200509063 |
0.563 |
|
| 2006 |
Yoon S, Seger R. The extracellular signal-regulated kinase: multiple substrates regulate diverse cellular functions. Growth Factors (Chur, Switzerland). 24: 21-44. PMID 16393692 DOI: 10.1080/02699050500284218 |
0.613 |
|
| 2006 |
Maik-Rachline G, Seger R. Variable phosphorylation states of pigment-epithelium-derived factor differentially regulate its function. Blood. 107: 2745-52. PMID 16322471 DOI: 10.1182/Blood-2005-06-2547 |
0.501 |
|
| 2006 |
Ben-Ami I, Freimann S, Armon L, Seger R, Amsterdam A, Ron-El R. P-832 Fertility and Sterility. 86: S442-S443. DOI: 10.1016/j.fertnstert.2006.07.1220 |
0.517 |
|
| 2005 |
Shaul Y, Seger R. The detection of MAPK signaling. Current Protocols in Cell Biology / Editorial Board, Juan S. Bonifacino ... [Et Al.]. Unit 14.3. PMID 18228462 DOI: 10.1002/0471143030.Cb1403S28 |
0.603 |
|
| 2005 |
Tarrab-Hazdai R, Hanoch T, Jeon SH, Pauli H, Gold D, Arnon R, Seger R. Ecto- and exo-protein kinases in Schistosoma mansoni: regulation of surface phosphorylation by acetylcholine and identification of the alpha subunit of CKII as a major secreted protein kinase. The Journal of Parasitology. 91: 756-63. PMID 17089740 DOI: 10.1645/Ge-458R.1 |
0.497 |
|
| 2005 |
Pollak L, Hanoch T, Rabey MJ, Seger R. Infectious inflammation of the CNS involves activation of mitogen-activated protein kinase and AKT proteins in CSF in humans. Neurological Sciences. 26: 324-329. PMID 16388366 DOI: 10.1007/S10072-005-0504-8 |
0.489 |
|
| 2005 |
Rubinfeld H, Seger R. The ERK cascade: a prototype of MAPK signaling. Molecular Biotechnology. 31: 151-74. PMID 16170216 DOI: 10.1385/Mb:31:2:151 |
0.596 |
|
| 2005 |
Bar J, Lukaschuk N, Zalcenstein A, Wilder S, Seger R, Oren M. The PI3K inhibitor LY294002 prevents p53 induction by DNA damage and attenuates chemotherapy-induced apoptosis. Cell Death and Differentiation. 12: 1578-87. PMID 15933740 DOI: 10.1038/Sj.Cdd.4401677 |
0.399 |
|
| 2005 |
Posen Y, Kalchenko V, Seger R, Brandis A, Scherz A, Salomon Y. Manipulation of redox signaling in mammalian cells enabled by controlled photogeneration of reactive oxygen species. Journal of Cell Science. 118: 1957-69. PMID 15840654 DOI: 10.1242/Jcs.02323 |
0.493 |
|
| 2005 |
Perlson E, Hanz S, Ben-Yaakov K, Segal-Ruder Y, Seger R, Fainzilber M. Vimentin-dependent spatial translocation of an activated MAP kinase in injured nerve. Neuron. 45: 715-26. PMID 15748847 DOI: 10.1016/J.Neuron.2005.01.023 |
0.436 |
|
| 2005 |
Chuderland D, Seger R. Protein-protein interactions in the regulation of the extracellular signal-regulated kinase. Molecular Biotechnology. 29: 57-74. PMID 15668520 DOI: 10.1385/Mb:29:1:57 |
0.798 |
|
| 2005 |
Petit I, Goichberg P, Spiegel A, Peled A, Brodie C, Seger R, Nagler A, Alon R, Lapidot T. Atypical PKC-zeta regulates SDF-1-mediated migration and development of human CD34+ progenitor cells. The Journal of Clinical Investigation. 115: 168-76. PMID 15630457 DOI: 10.1172/JCI21773 |
0.315 |
|
| 2005 |
Maik-Rachline G, Shaltiel S, Seger R. Extracellular phosphorylation converts pigment epithelium-derived factor from a neurotrophic to an antiangiogenic factor. Blood. 105: 670-8. PMID 15374885 DOI: 10.1182/Blood-2004-04-1569 |
0.509 |
|
| 2005 |
Yoon SH, Seger R, Choi EJ, Yoo YS. The Roles of Specific Residues on ERK2 for Nuclear Translocation in Response to Nerve Growth Factors in PC12 Cells Key Engineering Materials. 162-170. DOI: 10.4028/Www.Scientific.Net/Kem.277-279.162 |
0.543 |
|
| 2005 |
Reich-Zeliger S, Hanoch T, Seger R, Reisner Y. The Role of ERK5 Signaling in Tolerance Induction by Veto CTLs. Blood. 106: 3302-3302. DOI: 10.1182/Blood.V106.11.3302.3302 |
0.394 |
|
| 2005 |
Petit I, Goichberg P, Spiegel A, Peled A, Brodie C, Seger R, Nagler A, Alon R, Lapidot T. Atypical PKC-ζ regulates SDF-1–mediated migration and development of human CD34+ progenitor cells Journal of Clinical Investigation. 115: 168-176. DOI: 10.1172/Jci200521773 |
0.453 |
|
| 2004 |
Aebersold DM, Shaul YD, Yung Y, Yarom N, Yao Z, Hanoch T, Seger R. Extracellular signal-regulated kinase 1c (ERK1c), a novel 42-kilodalton ERK, demonstrates unique modes of regulation, localization, and function. Molecular and Cellular Biology. 24: 10000-15. PMID 15509801 DOI: 10.1128/Mcb.24.22.10000-10015.2004 |
0.571 |
|
| 2004 |
Kraus S, Levy G, Hanoch T, Naor Z, Seger R. Gonadotropin-releasing hormone induces apoptosis of prostate cancer cells: role of c-Jun NH2-terminal kinase, protein kinase B, and extracellular signal-regulated kinase pathways. Cancer Research. 64: 5736-44. PMID 15313914 DOI: 10.1158/0008-5472.Can-04-1156 |
0.569 |
|
| 2004 |
Yoon S, Seger R, Choi EJ, Yoo YS. SB203580 induces prolonged B-Raf activation and promotes neuronal differentiation upon EGF treatment of PC12 cells. Biochemistry. Biokhimii︠a︡. 69: 799-805. PMID 15310281 DOI: 10.1023/B:Biry.0000040206.71415.6F |
0.453 |
|
| 2004 |
Raviv Z, Kalie E, Seger R. MEK5 and ERK5 are localized in the nuclei of resting as well as stimulated cells, while MEKK2 translocates from the cytosol to the nucleus upon stimulation. Journal of Cell Science. 117: 1773-84. PMID 15075238 DOI: 10.1242/Jcs.01040 |
0.531 |
|
| 2004 |
Shaul YD, Seger R. Use of inhibitors in the study of MAPK signaling. Methods in Molecular Biology (Clifton, N.J.). 250: 113-26. PMID 14755084 DOI: 10.1385/1-59259-671-1:113 |
0.424 |
|
| 2004 |
Kraus S, Seger R. Determination of ERK activity: antiphospho-ERK antibodies, in vitro phosphorylation, and in-gel kinase assay. Methods in Molecular Biology (Clifton, N.J.). 250: 29-48. PMID 14755078 DOI: 10.1385/1-59259-671-1:29 |
0.528 |
|
| 2004 |
Rubinfeld H, Seger R. The ERK cascade as a prototype of MAPK signaling pathways. Methods in Molecular Biology (Clifton, N.J.). 250: 1-28. PMID 14755077 DOI: 10.1385/1-59259-671-1:1 |
0.485 |
|
| 2004 |
Bonfil D, Chuderland D, Kraus S, Shahbazian D, Friedberg I, Seger R, Naor Z. Extracellular signal-regulated kinase, Jun N-terminal kinase, p38, and c-Src are involved in gonadotropin-releasing hormone-stimulated activity of the glycoprotein hormone follicle-stimulating hormone β-subunit promoter Endocrinology. 145: 2228-2244. PMID 14736735 DOI: 10.1210/En.2003-1418 |
0.804 |
|
| 2004 |
Amsterdam A, Tajima K, Frajese V, Seger R. Analysis of signal transduction stimulated by gonadotropins in granulosa cells. Molecular and Cellular Endocrinology. 202: 77-80. PMID 12770734 DOI: 10.1016/S0303-7207(03)00066-2 |
0.634 |
|
| 2004 |
Rubinfeld H, Seger R. Detection of
MAP
Kinase Signaling Current Protocols in Molecular Biology. 67. DOI: 10.1002/0471142727.mb1812s67 |
0.347 |
|
| 2003 |
Kraus S, Benard O, Naor Z, Seger R. c-Src is activated by the epidermal growth factor receptor in a pathway that mediates JNK and ERK activation by gonadotropin-releasing hormone in COS7 cells. The Journal of Biological Chemistry. 278: 32618-30. PMID 12750372 DOI: 10.1074/Jbc.M303886200 |
0.563 |
|
| 2003 |
Tajima K, Dantes A, Yao Z, Sorokina K, Kotsuji F, Seger R, Amsterdam A. Down-regulation of steroidogenic response to gonadotropins in human and rat preovulatory granulosa cells involves mitogen-activated protein kinase activation and modulation of DAX-1 and steroidogenic factor-1. The Journal of Clinical Endocrinology and Metabolism. 88: 2288-99. PMID 12727988 DOI: 10.1210/Jc.2002-020913 |
0.491 |
|
| 2003 |
Josefsberg LB, Galiani D, Lazar S, Kaufman O, Seger R, Dekel N. Maturation-promoting factor governs mitogen-activated protein kinase activation and interphase suppression during meiosis of rat oocytes. Biology of Reproduction. 68: 1282-90. PMID 12606439 DOI: 10.1095/Biolreprod.102.006882 |
0.51 |
|
| 2003 |
Harris D, Chuderland D, Bonfil D, Kraus S, Seger R, Naor Z. Extracellular signal-regulated kinase and c-Src, but not Jun N-terminal kinase, are involved in basal and gonadotropin-releasing hormone-stimulated activity of the glycoprotein hormone alpha-subunit promoter. Endocrinology. 144: 612-22. PMID 12538624 DOI: 10.1210/En.2002-220690 |
0.786 |
|
| 2002 |
Harris D, Bonfil D, CHuderland D, Kraus S, Seger R, Naor Z. Activation of MAPK Cascades by GnRH: ERK and Jun N-Terminal Kinase Are Involved in Basal and GnRH-Stimulated Activity of the Glycoprotein Hormone LHβ-Subunit Promoter. Endocrinology. 143: 1018-1025. PMID 28201441 DOI: 10.1210/endo.143.3.8675 |
0.776 |
|
| 2002 |
Oren M, Damalas A, Gottlieb T, Michael D, Taplick J, Leal JF, Maya R, Moas M, Seger R, Taya Y, Ben-Ze'Ev A. Regulation of p53: intricate loops and delicate balances. Annals of the New York Academy of Sciences. 973: 374-83. PMID 12485897 DOI: 10.1111/J.1749-6632.2002.Tb04669.X |
0.415 |
|
| 2002 |
Shi H, Asher C, Yung Y, Kligman L, Reuveny E, Seger R, Garty H. Casein kinase 2 specifically binds to and phosphorylates the carboxy termini of ENaC subunits. European Journal of Biochemistry / Febs. 269: 4551-8. PMID 12230567 DOI: 10.1046/J.1432-1033.2002.03154.X |
0.527 |
|
| 2002 |
Oren M, Damalas A, Gottlieb T, Michael D, Taplick J, Leal JF, Maya R, Moas M, Seger R, Taya Y, Ben-Ze'ev A. Regulation of p53: intricate loops and delicate balances. Biochemical Pharmacology. 64: 865-71. PMID 12213580 DOI: 10.1016/S0006-2952(02)01149-8 |
0.409 |
|
| 2002 |
Wolf I, Seger R. The mitogen-activated protein kinase signaling cascade: from bench to bedside. The Israel Medical Association Journal : Imaj. 4: 641-7. PMID 12183875 |
0.522 |
|
| 2002 |
Amsterdam A, Hanoch T, Dantes A, Tajima K, Strauss JF, Seger R. Mechanisms of gonadotropin desensitization. Molecular and Cellular Endocrinology. 187: 69-74. PMID 11988313 DOI: 10.1016/S0303-7207(01)00701-8 |
0.48 |
|
| 2002 |
Harris D, Bonfil D, Chuderland D, Kraus S, Seger R, Naor Z. Activation of MAPK cascades by GnRH: ERK and Jun N-terminal kinase are involved in basal and GnRH-stimulated activity of the glycoprotein hormone LHbeta-subunit promoter. Endocrinology. 143: 1018-25. PMID 11861527 DOI: 10.1210/Endo.143.3.8675 |
0.791 |
|
| 2002 |
Gottlieb TM, Leal JF, Seger R, Taya Y, Oren M. Cross-talk between Akt, p53 and Mdm2: possible implications for the regulation of apoptosis. Oncogene. 21: 1299-303. PMID 11850850 DOI: 10.1038/Sj.Onc.1205181 |
0.503 |
|
| 2002 |
Bar-Shira A, Rashi-Elkeles S, Zlochover L, Moyal L, Smorodinsky NI, Seger R, Shiloh Y. ATM-dependent activation of the gene encoding MAP kinase phosphatase 5 by radiomimetic DNA damage. Oncogene. 21: 849-55. PMID 11850813 DOI: 10.1038/Sj.Onc.1205127 |
0.464 |
|
| 2002 |
Shi H, Asher C, Chigaev A, Yung Y, Reuveny E, Seger R, Garty H. Interactions of beta and gamma ENaC with Nedd4 can be facilitated by an ERK-mediated phosphorylation. The Journal of Biological Chemistry. 277: 13539-47. PMID 11805112 DOI: 10.1074/Jbc.M111717200 |
0.506 |
|
| 2001 |
Yao Z, Seger R. Immunological detection of phosphorylation Current Protocols in Cell Biology / Editorial Board, Juan S. Bonifacino ... [Et Al.]. PMID 18228325 DOI: 10.1002/0471143030.Cb1402S00 |
0.451 |
|
| 2001 |
Yao Z, Flash I, Raviv Z, Yung Y, Asscher Y, Pleban S, Seger R. Non-regulated and stimulated mechanisms cooperate in the nuclear accumulation of MEK1. Oncogene. 20: 7588-96. PMID 11753637 DOI: 10.1038/Sj.Onc.1204963 |
0.495 |
|
| 2001 |
Kraus S, Naor Z, Seger R. Intracellular Signaling Pathways Mediated by the Gonadotropin-Releasing Hormone (GnRH) Receptor Archives of Medical Research. 32: 499-509. PMID 11750725 DOI: 10.1016/S0188-4409(01)00331-9 |
0.547 |
|
| 2001 |
Shacham S, Harris D, Ben-Shlomo H, Cohen I, Bonfil D, Przedecki F, Lewy H, Ashkenazi IE, Seger R, Naor Z. Mechanism of GnRH receptor signaling on gonadotropin release and gene expression in pituitary gonadotrophs. Vitamins and Hormones. 63: 63-90. PMID 11358118 DOI: 10.1016/S0083-6729(01)63003-6 |
0.418 |
|
| 2001 |
Chigaev A, Lu G, Shi H, Asher C, Xu R, Latter H, Seger R, Garty H, Reuveny E. In vitro phosphorylation of COOH termini of the epithelial Na(+) channel and its effects on channel activity in Xenopus oocytes. American Journal of Physiology. Renal Physiology. 280: F1030-6. PMID 11352843 DOI: 10.1152/Ajprenal.2001.280.6.F1030 |
0.426 |
|
| 2001 |
Bacus SS, Gudkov AV, Lowe M, Lyass L, Yung Y, Komarov AP, Keyomarsi K, Yarden Y, Seger R. Taxol-induced apoptosis depends on MAP kinase pathways (ERK and p38) and is independent of p53. Oncogene. 20: 147-55. PMID 11313944 DOI: 10.1038/Sj.Onc.1204062 |
0.458 |
|
| 2001 |
Kraus S, Seger R, Fishelson Z. Involvement of the ERK mitogen-activated protein kinase in cell resistance to complement-mediated lysis. Clinical and Experimental Immunology. 123: 366-74. PMID 11298121 DOI: 10.1046/J.1365-2249.2001.01477.X |
0.543 |
|
| 2001 |
Seger D, Seger R, Shaltiel S. The CK2 phosphorylation of vitronectin. Promotion of cell adhesion via the alpha(v)beta 3-phosphatidylinositol 3-kinase pathway. The Journal of Biological Chemistry. 276: 16998-7006. PMID 11278271 DOI: 10.1074/Jbc.M003766200 |
0.452 |
|
| 2001 |
Brand A, Gil S, Seger R, Yavin E. Lipid constituents in oligodendroglial cells alter susceptibility to H2O2-induced apoptotic cell death via ERK activation. Journal of Neurochemistry. 76: 910-8. PMID 11158263 DOI: 10.1046/J.1471-4159.2001.00085.X |
0.426 |
|
| 2000 |
Chen Y, Li X, Eswarakumar VP, Seger R, Lonai P. Fibroblast growth factor (FGF) signaling through PI 3-kinase and Akt/PKB is required for embryoid body differentiation. Oncogene. 19: 3750-6. PMID 10949929 DOI: 10.1038/Sj.Onc.1203726 |
0.505 |
|
| 2000 |
Shinitzky M, Haimovitz R, Nemas M, Cahana N, Mamillapalli R, Seger R. Induction of intracellular signalling by cyclic glycerophosphates and their deoxy analogues. European Journal of Biochemistry / Febs. 267: 2547-54. PMID 10785374 DOI: 10.1046/J.1432-1327.2000.01265.X |
0.533 |
|
| 2000 |
Naor Z, Benard O, Seger R. Activation of MAPK Cascades by G-protein-coupled Receptors: The Case of Gonadotropin-releasing Hormone Receptor Trends in Endocrinology and Metabolism. 11: 91-99. PMID 10707049 DOI: 10.1016/S1043-2760(99)00232-5 |
0.601 |
|
| 2000 |
Yao Z, Dolginov Y, Hanoch T, Yung Y, Ridner G, Lando Z, Zharhary D, Seger R. Detection of partially phosphorylated forms of ERK by monoclonal antibodies reveals spatial regulation of ERK activity by phosphatases Febs Letters. 468: 37-42. PMID 10683437 DOI: 10.1016/S0014-5793(00)01191-1 |
0.606 |
|
| 2000 |
Talmor D, Artru AA, Seger R, Hanoc T, Shapira Y. Room F, 10/16/2000 9: 00 AM - 11: 00 AM (PS) Activation of Mitogen-Activated Protein Kinase Signalling Following Traumatic Brain Injury in Rats Anesthesiology. 93: A-712. DOI: 10.1097/00000542-200009001-00712 |
0.316 |
|
| 1999 |
Rubinfeld H, Hanoch T, Seger R. Identification of a Cytoplasmic-Retention Sequence in ERK2 Journal of Biological Chemistry. 274: 30349-30352. PMID 10521408 DOI: 10.1074/Jbc.274.43.30349 |
0.601 |
|
| 1999 |
Wright JH, Munar E, Jameson DR, Andreassen PR, Margolis RL, Seger R, Krebs EG. Mitogen-activated protein kinase kinase activity is required for the G(2)/M transition of the cell cycle in mammalian fibroblasts. Proceedings of the National Academy of Sciences of the United States of America. 96: 11335-40. PMID 10500177 DOI: 10.1073/Pnas.96.20.11335 |
0.464 |
|
| 1999 |
Paz K, Liu YF, Shorer H, Hemi R, LeRoith D, Quan M, Kanety H, Seger R, Zick Y. Phosphorylation of insulin receptor substrate-1 (IRS-1) by protein kinase B positively regulates IRS-1 function Journal of Biological Chemistry. 274: 28816-28822. PMID 10497255 DOI: 10.1074/Jbc.274.40.28816 |
0.479 |
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| 1999 |
Sapir T, Cahana A, Seger R, Nekhai S, Reiner O. LIS1 is a microtubule-associated phosphoprotein. European Journal of Biochemistry / Febs. 265: 181-8. PMID 10491172 DOI: 10.1046/J.1432-1327.1999.00711.X |
0.561 |
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| 1999 |
Waterman H, Alroy I, Strano S, Seger R, Yarden Y. The C-terminus of the kinase-defective neuregulin receptor ErbB-3 confers mitogenic superiority and dictates endocytic routing Embo Journal. 18: 3348-3358. PMID 10369675 DOI: 10.1093/Emboj/18.12.3348 |
0.513 |
|
| 1999 |
Alroy I, Soussan L, Seger R, Yarden Y. Neu differentiation factor stimulates phosphorylation and activation of the Sp1 transcription factor Molecular and Cellular Biology. 19: 1961-1972. PMID 10022883 DOI: 10.1128/Mcb.19.3.1961 |
0.476 |
|
| 1999 |
Oren A, Herschkovitz A, Ben-Dror I, Holdengreber V, Ben-Shaul Y, Seger R, Vardimon L. The cytoskeletal network controls c-Jun expression and glucocorticoid receptor transcriptional activity in an antagonistic and cell-type-specific manner. Molecular and Cellular Biology. 19: 1742-50. PMID 10022861 DOI: 10.1128/Mcb.19.3.1742 |
0.483 |
|
| 1999 |
Silverman MA, Benard O, Jaaro H, Rattner A, Citri Y, Seger R. CPG16, a novel protein serine/threonine kinase downstream of cAMP-dependent protein kinase. The Journal of Biological Chemistry. 274: 2631-6. PMID 9915791 DOI: 10.1074/Jbc.274.5.2631 |
0.595 |
|
| 1999 |
Yablonka-Reuveni Z, Seger R, Rivera AJ. Fibroblast growth factor promotes recruitment of skeletal muscle satellite cells in young and old rats Journal of Histochemistry and Cytochemistry. 47: 23-42. PMID 9857210 DOI: 10.1177/002215549904700104 |
0.352 |
|
| 1999 |
Arava Y, Seger R, Walker MD. GRFβ, a novel regulator of calcium signaling, is expressed in pancreatic beta cells and brain Journal of Biological Chemistry. 274: 24449-24452. DOI: 10.1074/Jbc.274.35.24449 |
0.47 |
|
| 1998 |
Berman DE, Hazvi S, Rosenblum K, Seger R, Dudai Y. Specific and differential activation of mitogen-activated protein kinase cascades by unfamiliar taste in the insular cortex of the behaving rat. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 18: 10037-44. PMID 9822758 DOI: 10.1523/Jneurosci.18-23-10037.1998 |
0.462 |
|
| 1998 |
Pinkas-Kramarski R, Shelly M, Guarino BC, Wang LM, Lyass L, Alroy I, Alamandi M, Kuo A, Moyer JD, Lavi S, Eisenstein M, Ratzkin BJ, Seger R, Bacus SS, Pierce JH, et al. ErbB tyrosine kinases and the two neuregulin families constitute a ligand-receptor network Molecular and Cellular Biology. 18: 6090-6101. PMID 9742126 DOI: 10.1128/Mcb.18.10.6090 |
0.425 |
|
| 1998 |
Avraham A, Jung S, Samuels Y, Seger R, Ben-Neriah Y. Co-stimulation-dependent activation of a JNK-kinase in T lymphocytes. European Journal of Immunology. 28: 2320-30. PMID 9710210 DOI: 10.1002/(Sici)1521-4141(199808)28:08<2320::Aid-Immu2320>3.0.Co;2-K |
0.519 |
|
| 1998 |
Hevroni D, Rattner A, Bundman M, Lederfein D, Gabarah A, Mangelus M, Silverman MA, Kedar H, Naor C, Kornuc M, Hanoch T, Seger R, Theill LE, Nedivi E, Richter-Levin G, et al. Hippocampal plasticity involves extensive gene induction and multiple cellular mechanisms. Journal of Molecular Neuroscience : Mn. 10: 75-98. PMID 9699150 DOI: 10.1007/Bf02737120 |
0.402 |
|
| 1998 |
Levi NL, Hanoch T, Benard O, Rozenblat M, Harris D, Reiss N, Naor Z, Seger R. Stimulation of Jun N-terminal kinase (JNK) by gonadotropin-releasing hormone in pituitary alpha T3-1 cell line is mediated by protein kinase C, c-Src, and CDC42. Molecular Endocrinology (Baltimore, Md.). 12: 815-24. PMID 9626657 DOI: 10.1210/Mend.12.6.0120 |
0.625 |
|
| 1998 |
Michael D, Martin KC, Seger R, Ning MM, Baston R, Kandel ER. Repeated pulses of serotonin required for long-term facilitation activate mitogen-activated protein kinase in sensory neurons of Aplysia. Proceedings of the National Academy of Sciences of the United States of America. 95: 1864-9. PMID 9465108 DOI: 10.1073/Pnas.95.4.1864 |
0.408 |
|
| 1998 |
Sadot E, Jaaro H, Seger R, Ginzburg I. Ras-signaling pathways: positive and negative regulation of tau expression in PC12 cells. Journal of Neurochemistry. 70: 428-31. PMID 9422391 DOI: 10.1046/J.1471-4159.1998.70010428.X |
0.478 |
|
| 1998 |
Rubinfeld H, Seger R. Detection of MAP Kinase Signaling Current Protocols in Pharmacology. DOI: 10.1002/0471143030.Cb1403S00 |
0.605 |
|
| 1997 |
Reiss N, Llevi LN, Shacham S, Harris D, Seger R, Naor Z. Mechanism of Mitogen-Activated Protein Kinase Activation by Gonadotropin-Releasing Hormone in the Pituitary αT3-1 Cell Line: Differential Roles of Calcium and Protein Kinase C. Endocrinology. 138: 1673-1682. PMID 28199612 DOI: 10.1210/Endo.138.4.5057 |
0.602 |
|
| 1997 |
Gabay L, Seger R, Shilo BZ. In situ activation pattern of Drosophila EGF receptor pathway during development Science. 277: 1103-1106. PMID 9262480 DOI: 10.1126/Science.277.5329.1103 |
0.501 |
|
| 1997 |
Yung Y, Dolginov Y, Yao Z, Rubinfeld H, Michael D, Hanoch T, Roubini E, Lando Z, Zharhary D, Seger R. Detection of ERK activation by a novel monoclonal antibody. Febs Letters. 408: 292-6. PMID 9188779 DOI: 10.1016/S0014-5793(97)00442-0 |
0.528 |
|
| 1997 |
Jaaro H, Rubinfeld H, Hanoch T, Seger R. Nuclear translocation of mitogen-activated protein kinase kinase (MEK1) in response to mitogenic stimulation Proceedings of the National Academy of Sciences of the United States of America. 94: 3742-3747. PMID 9108048 DOI: 10.1073/Pnas.94.8.3742 |
0.595 |
|
| 1997 |
Berman D, Hazvi S, Lamprecht R, Seger R, Dudai Y. Taste experience activates MAP kinase in the rat insular cortex Neuroscience Letters. 237: S10. DOI: 10.1016/S0304-3940(97)90039-2 |
0.365 |
|
| 1997 |
Chitlaru E, Seger R, Pick U. Activation of a 74 kDa plasma membrane protein kinase by hyperosmotic shocks in the halotolerant alga Dunaliella salina Journal of Plant Physiology. 151: 429-436. DOI: 10.1016/S0176-1617(97)80007-7 |
0.513 |
|
| 1996 |
Pinkas-Kramarski R, Soussan L, Waterman H, Levkowitz G, Alroy I, Klapper L, Lavi S, Seger R, Ratzkin BJ, Sela M, Yarden Y. Diversification of Neu differentiation factor and epidermal growth factor signaling by combinatorial receptor interactions. The Embo Journal. 15: 2452-67. PMID 8665853 DOI: 10.1002/J.1460-2075.1996.Tb00603.X |
0.516 |
|
| 1996 |
Karunagaran D, Tzahar E, Beerli RR, Chen X, Graus-Porta D, Ratzkin BJ, Seger R, Hynes NE, Yarden Y. ErbB-2 is a common auxiliary subunit of NDF and EGF receptors: implications for breast cancer. The Embo Journal. 15: 254-264. DOI: 10.1002/J.1460-2075.1996.Tb00356.X |
0.396 |
|
| 1995 |
Baum L, Seger R, Woodgett JR, Kawabata S, Maruyama K, Koyama M, Silver J, Saitoh T. Overexpressed tau protein in cultured cells is phosphorylated without formation of PHF: implication of phosphoprotein phosphatase involvement Molecular Brain Research. 34: 1-17. PMID 8750856 DOI: 10.1016/0169-328X(95)00111-5 |
0.467 |
|
| 1995 |
Naor Z, Shacham S, Harris D, Seger R, Reiss N. Signal transduction of the gonadotropin releasing hormone (GnRH) receptor: cross-talk of calcium, protein kinase C (PKC), and arachidonic acid. Cellular and Molecular Neurobiology. 15: 527-544. PMID 8719039 DOI: 10.1007/Bf02071315 |
0.394 |
|
| 1995 |
Alberola-Ila J, Forbush KA, Seger R, Krebs EG, Perlmutter RM. Selective requirement for MAP kinase activation in thymocyte differentiation. Nature. 373: 620-3. PMID 7854419 DOI: 10.1038/373620A0 |
0.473 |
|
| 1995 |
Eldar-Finkelman H, Seger R, Vandenheede JR, Krebs EG. Inactivation of glycogen synthase kinase-3 by epidermal growth factor is mediated by mitogen-activated protein kinase/p90 ribosomal protein S6 kinase signaling pathway in NIH/3T3 cells. The Journal of Biological Chemistry. 270: 987-90. PMID 7836418 DOI: 10.1074/Jbc.270.3.987 |
0.59 |
|
| 1995 |
Campbell JS, Seger R, Graves JD, Graves LM, Jensen AM, Krebs EG. The MAP kinase cascade. Recent Progress in Hormone Research. 50: 131-59. PMID 7740155 DOI: 10.1016/B978-0-12-571150-0.50011-1 |
0.582 |
|
| 1995 |
Schweitzer R, Shaharabany M, Seger R, Shilo BZ. Secreted Spitz triggers the DER signaling pathway and is a limiting component in embryonic ventral ectoderm determination Genes and Development. 9: 1518-1529. PMID 7601354 DOI: 10.1101/Gad.9.12.1518 |
0.547 |
|
| 1995 |
Seger R, Krebs EG. The MAPK signaling cascade. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 9: 726-35. PMID 7601337 DOI: 10.1096/Fasebj.9.9.7601337 |
0.568 |
|
| 1995 |
Northrop J, Woods A, Seger R, Suzuki A, Ueno N, Krebs E, Kimelman D. BMP-4 Regulates the Dorsal-Ventral Differences in FGF/MAPKK-Mediated Mesoderm Induction inXenopus Developmental Biology. 172: 242-252. PMID 7589804 DOI: 10.1006/Dbio.1995.0019 |
0.409 |
|
| 1995 |
Reszka AA, Seger R, Diltz CD, Krebs EG, Fischer EH. Association of mitogen-activated protein kinase with the microtubule cytoskeleton. Proceedings of the National Academy of Sciences of the United States of America. 92: 8881-5. PMID 7568036 DOI: 10.1073/Pnas.92.19.8881 |
0.502 |
|
| 1995 |
Seger R, Biener Y, Feinstein R, Hanoch T, Gazit A, Zick Y. Differential activation of mitogen-activated protein kinase and S6 kinase signaling pathways by 12-O-tetradecanoylphorbol-13-acetate (TPA) and insulin. Evidence for involvement of a TPA-stimulated protein-tyrosine kinase Journal of Biological Chemistry. 270: 28325-28330. PMID 7499332 DOI: 10.1074/Jbc.270.47.28325 |
0.566 |
|
| 1995 |
Seger R, Krebs EG. The MAPK signaling cascade The Faseb Journal. 9: 726-735. DOI: 10.1096/fasebj.9.9.7601337 |
0.334 |
|
| 1993 |
Ahn NG, Campbell JS, Seger R, Jensen AL, Graves LM, Krebs EG. Metabolic labeling of mitogen-activated protein kinase kinase in A431 cells demonstrates phosphorylation on serine and threonine residues. Proceedings of the National Academy of Sciences of the United States of America. 90: 5143-7. PMID 8389470 DOI: 10.1073/Pnas.90.11.5143 |
0.549 |
|
| 1992 |
Ahn NG, Seger R, Krebs EG. The mitogen-activated protein kinase activator. Current Opinion in Cell Biology. 4: 992-9. PMID 1485970 DOI: 10.1016/0955-0674(92)90131-U |
0.57 |
|
| 1992 |
Ahn NG, Robbins DJ, Haycock JW, Seger R, Cobb MH, Krebs EG. Identification of an activator of the microtubule-associated protein 2 kinases ERK1 and ERK2 in PC12 cells stimulated with nerve growth factor or bradykinin. Journal of Neurochemistry. 59: 147-56. PMID 1319464 DOI: 10.1111/J.1471-4159.1992.Tb08885.X |
0.577 |
|
| 1991 |
Seger R, Ahn NG, Boulton TG, Yancopoulos GD, Panayotatos N, Radziejewska E, Ericsson L, Bratlien RL, Cobb MH, Krebs EG. Microtubule-associated protein 2 kinases, ERK1 and ERK2, undergo autophosphorylation on both tyrosine and threonine residues: implications for their mechanism of activation. Proceedings of the National Academy of Sciences of the United States of America. 88: 6142-6. PMID 1712480 DOI: 10.1073/Pnas.88.14.6142 |
0.555 |
|
| 1989 |
Seger R, Zick Y, Shaltiel S. Studying the structure of the intracellular moiety of the insulin receptor with a kinase-splitting membranal proteinase Embo Journal. 8: 435-440. PMID 2656255 DOI: 10.1002/J.1460-2075.1989.Tb03395.X |
0.488 |
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