Vamsi Mootha - Related publications

Harvard University, Cambridge, MA, United States 
Cell Biology, Bioinformatics Biology
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50 most relevant papers in past 60 days:
Year Citation  Score
2020 Basu U, Bostwick AM, Das K, Dittenhafer-Reed KE, Patel SS. Structure, mechanism, and regulation of mitochondrial DNA transcription initiation. The Journal of Biological Chemistry. PMID 33127643 DOI: 10.1074/jbc.REV120.011202   
2020 McLaughlin KL, Hagen JT, Coalson HS, Nelson MAM, Kew KA, Wooten AR, Fisher-Wellman KH. Novel approach to quantify mitochondrial content and intrinsic bioenergetic efficiency across organs. Scientific Reports. 10: 17599. PMID 33077793 DOI: 10.1038/s41598-020-74718-1   
2020 Hathazi D, Griffin H, Jennings MJ, Giunta M, Powell C, Pearce SF, Munro B, Wei W, Boczonadi V, Poulton J, Pyle A, Calabrese C, Gomez-Duran A, Schara U, Pitceathly RD, et al. Metabolic shift underlies recovery in reversible infantile respiratory chain deficiency. The Embo Journal. e105364. PMID 33128823 DOI: 10.15252/embj.2020105364   
2020 Tomar D, Elrod JW. Metabolite regulation of the mitochondrial calcium uniporter channel. Cell Calcium. 92: 102288. PMID 32956979 DOI: 10.1016/j.ceca.2020.102288   
2020 Gasier HG, Dohl J, Suliman HB, Piantadosi CA, Yu T. Skeletal muscle mitochondrial fragmentation and impaired bioenergetics from nutrient overload is prevented by carbon monoxide. American Journal of Physiology. Cell Physiology. PMID 32845721 DOI: 10.1152/ajpcell.00016.2020   
2020 May AI, Prescott M, Ohsumi Y. Autophagy facilitates adaptation of budding yeast to respiratory growth by recycling serine for one-carbon metabolism. Nature Communications. 11: 5052. PMID 33028817 DOI: 10.1038/s41467-020-18805-x   
2020 Zhu Z, Cao D, Xu L, Song C, Wang Y, Li M, Yan J, Xie Z. Effect of Orexin-A on Mitochondrial Biogenesis, Mitophagy and Structure in HEK293-APPSWE Cell Model of Alzheimer's Disease. Clinical and Experimental Pharmacology & Physiology. PMID 33080054 DOI: 10.1111/1440-1681.13424   
2020 Murphy E, Steenbergen C. Regulation of Mitochondrial Ca Uptake. Annual Review of Physiology. PMID 33141632 DOI: 10.1146/annurev-physiol-031920-092419   
2020 Kong H, Reczek CR, McElroy GS, Steinert EM, Wang T, Sabatini DM, Chandel NS. Metabolic determinants of cellular fitness dependent on mitochondrial reactive oxygen species. Science Advances. 6. PMID 33148642 DOI: 10.1126/sciadv.abb7272   
2020 Perks KL, Ferreira N, Ermer JA, Rudler DL, Richman TR, Rossetti G, Matthews VB, Ward NC, Rackham O, Filipovska A. Reduced mitochondrial translation prevents diet-induced metabolic dysfunction but not inflammation. Aging. 12. PMID 33024056 DOI: 10.18632/aging.104010   
2020 Daussin FN, Heyman E, Burelle Y. Effects of (-)-epicatechin on mitochondria. Nutrition Reviews. PMID 32989466 DOI: 10.1093/nutrit/nuaa094   
2020 Cui Y, Pan M, Ma J, Song X, Cao W, Zhang P. Recent progress in the use of mitochondrial membrane permeability transition pore in mitochondrial dysfunction-related disease therapies. Molecular and Cellular Biochemistry. PMID 33000352 DOI: 10.1007/s11010-020-03926-0   
2020 Moehlman AT, Youle RJ. Mitochondrial Quality Control and Restraining Innate Immunity. Annual Review of Cell and Developmental Biology. 36: 265-289. PMID 33021820 DOI: 10.1146/annurev-cellbio-021820-101354   
2020 Lopez Sanchez MIG, Ziemann M, Bachem A, Makam R, Crowston JG, Pinkert CA, McKenzie M, Bedoui S, Trounce IA. Nuclear response to divergent mitochondrial DNA genotypes modulates the interferon immune response. Plos One. 15: e0239804. PMID 33031404 DOI: 10.1371/journal.pone.0239804   
2020 Kaplan P, Tatarkova Z, Sivonova MK, Racay P, Lehotsky J. Homocysteine and Mitochondria in Cardiovascular and Cerebrovascular Systems. International Journal of Molecular Sciences. 21. PMID 33080955 DOI: 10.3390/ijms21207698   
2020 Kory N, Uit de Bos J, van der Rijt S, Jankovic N, Güra M, Arp N, Pena IA, Prakash G, Chan SH, Kunchok T, Lewis CA, Sabatini DM. MCART1/SLC25A51 is required for mitochondrial NAD transport. Science Advances. 6. PMID 33087354 DOI: 10.1126/sciadv.abe5310   
2020 Moon SJ, Dong W, Stephanopoulos GN, Sikes HD. Oxidative pentose phosphate pathway and glucose anaplerosis support maintenance of mitochondrial NADPH pool under mitochondrial oxidative stress. Bioengineering & Translational Medicine. 5: e10184. PMID 33005744 DOI: 10.1002/btm2.10184   
2020 Li Z, Li X, He X, Jia X, Zhang X, Lu B, Zhao J, Lu J, Chen L, Dong Z, Liu K, Dong Z. Proteomics Reveal the Inhibitory Mechanism of Levodopa Against Esophageal Squamous Cell Carcinoma. Frontiers in Pharmacology. 11: 568459. PMID 33101026 DOI: 10.3389/fphar.2020.568459   
2020 Corum DG, Jenkins DP, Heslop JA, Tallent LM, Beeson GC, Barth JL, Schnellmann RG, Muise-Helmericks RC. PDE5 inhibition rescues mitochondrial dysfunction and angiogenic responses induced by Akt3 inhibition by promotion of PRC expression. The Journal of Biological Chemistry. PMID 33087445 DOI: 10.1074/jbc.RA120.013716   
2020 Wang J, Zhou H. Mitochondrial quality control mechanisms as molecular targets in cardiac ischemiareperfusion injury. Acta Pharmaceutica Sinica. B. 10: 1866-1879. PMID 33163341 DOI: 10.1016/j.apsb.2020.03.004   
2020 De R, Mazumder S, Bandyopadhyay U. Mediators of mitophagy that regulate mitochondrial quality control play crucial role in diverse pathophysiology. Cell Biology and Toxicology. PMID 33067701 DOI: 10.1007/s10565-020-09561-1   
2020 Ajaz S, McPhail MJ, Singh KK, Mujib S, Trovato FM, Napoli S, Agarwal K. Mitochondrial metabolic manipulation by SARS-CoV-2 in peripheral blood mononuclear cells of COVID-19 patients. American Journal of Physiology. Cell Physiology. PMID 33151090 DOI: 10.1152/ajpcell.00426.2020   
2020 Chen Y, Guo S, Tang Y, Mou C, Hu X, Shao F, Yan W, Wu Q. Mitochondrial Fusion and Fission in Neuronal Death Induced by Cerebral Ischemia-Reperfusion and Its Clinical Application: A Mini-Review. Medical Science Monitor : International Medical Journal of Experimental and Clinical Research. 26: e928651. PMID 33156817 DOI: 10.12659/MSM.928651   
2020 Moore T, Yanes RE, Calton MA, Vollrath D, Enns GM, Cowan TM. AMP-independent activator of AMPK for treatment of mitochondrial disorders. Plos One. 15: e0240517. PMID 33052980 DOI: 10.1371/journal.pone.0240517   
2020 Wajner M, Vargas CR, Amaral AU. Disruption of mitochondrial functions and oxidative stress contribute to neurologic dysfunction in organic acidurias. Archives of Biochemistry and Biophysics. 108646. PMID 33098870 DOI: 10.1016/   
2020 Lin PH, Duann P. Dyslipidemia in Kidney Disorders: Perspectives on Mitochondria Homeostasis and Therapeutic Opportunities. Frontiers in Physiology. 11: 1050. PMID 33013450 DOI: 10.3389/fphys.2020.01050   
2020 Terriente-Felix A, Wilson EL, Whitworth AJ. Drosophila phosphatidylinositol-4 kinase fwd promotes mitochondrial fission and can suppress Pink1/parkin phenotypes. Plos Genetics. 16: e1008844. PMID 33085661 DOI: 10.1371/journal.pgen.1008844   
2020 Li X, Ma L, Fu P. The Mitochondrion-targeted Antioxidants in Kidney Disease. Current Medicinal Chemistry. PMID 33081669 DOI: 10.2174/0929867327666201020151124   
2020 Zhang P, Li L, Sun H, Zhang Y, Zhang G, Zhang T, Zeng C. Mitochondrial Energy-Regulating Effect of Atractyloside Inhibits Hepatocellular Steatosis Through the Activation of Autophagy. Frontiers in Pharmacology. 11: 575695. PMID 33101031 DOI: 10.3389/fphar.2020.575695   
2020 Zhu L, Chen Z, Han K, Zhao Y, Li Y, Li D, Wang X, Li X, Sun S, Lin F, Zhao G. Correlation between Mitochondrial Dysfunction, Cardiovascular Diseases, and Traditional Chinese Medicine. Evidence-Based Complementary and Alternative Medicine : Ecam. 2020: 2902136. PMID 33101442 DOI: 10.1155/2020/2902136   
2020 Saku T, Takashio S, Tsuruta Y, Otsuka Y, Takae M, Kiyama T, Yamamoto E, Kaikita K, Hotta T, Matsumoto S, Kang D, Tsujita K, Komohara Y. Comparison of electron microscopic findings and clinical presentation in three patients with mitochondrial cardiomyopathy caused by the mitochondrial DNA mutation m.3243A > G. Medical Molecular Morphology. PMID 33113037 DOI: 10.1007/s00795-020-00268-0   
2020 Jamwal S, Blackburn J, Elsworth JD. PPARγ/PGC1α signaling as a potential therapeutic target for mitochondrial biogenesis in neurodegenerative disorders. Pharmacology & Therapeutics. 107705. PMID 33039420 DOI: 10.1016/j.pharmthera.2020.107705   
2020 Yang L, Slone J, Zou W, Queme LF, Jankowski MP, Yin F, Huang T. Systemic Delivery of AAV- Mitigates the Phenotypes of Mitochondrial Disorders in Mutant Mice. Molecular Therapy. Methods & Clinical Development. 18: 84-97. PMID 32995353 DOI: 10.1016/j.omtm.2020.05.021   
2020 Lopes C, Tang Y, Anjo SI, Manadas B, Onofre I, de Almeida LP, Daley GQ, Schlaeger TM, Rego ACC. Mitochondrial and Redox Modifications in Huntington Disease Induced Pluripotent Stem Cells Rescued by CRISPR/Cas9 CAGs Targeting. Frontiers in Cell and Developmental Biology. 8: 576592. PMID 33072759 DOI: 10.3389/fcell.2020.576592   
2020 Ansari MY, Ahmad N, Voleti S, Wase SJ, Novak K, Haqqi TM. Mitochondrial dysfunction triggers catabolic response in chondrocytes via ROS mediated activation of JNK/AP1 pathway. Journal of Cell Science. PMID 33097606 DOI: 10.1242/jcs.247353   
2020 Juárez-Flores DL, Ezquerra M, Gonzàlez-Casacuberta Ï, Ormazabal A, Morén C, Tolosa E, Fucho R, Guitart-Mampel M, Casado M, Valldeoriola F, de la Torre-Lara J, Muñoz E, Tobías E, Compta Y, García-García FJ, et al. Disrupted Mitochondrial and Metabolic Plasticity Underlie Comorbidity between Age-Related and Degenerative Disorders as Parkinson Disease and Type 2 Diabetes Mellitus. Antioxidants (Basel, Switzerland). 9. PMID 33143119 DOI: 10.3390/antiox9111063   
2020 Fisher JJ, Vanderpeet CL, Bartho LA, McKeating DR, Cuffe JSM, Holland OJ, Perkins AV. Mitochondrial dysfunction in placental trophoblast cells experiencing gestational diabetes mellitus. The Journal of Physiology. PMID 33135816 DOI: 10.1113/JP280593   
2020 Gujarati NA, Vasquez JM, Bogenhagen DF, Mallipattu SK. The Complicated Role of Mitochondria in the Podocyte. American Journal of Physiology. Renal Physiology. PMID 33073585 DOI: 10.1152/ajprenal.00393.2020   
2020 Glausier JR, Enwright JF, Lewis DA. Diagnosis- and Cell Type-Specific Mitochondrial Functional Pathway Signatures in Schizophrenia and Bipolar Disorder. The American Journal of Psychiatry. appiajp202019111210. PMID 33115248 DOI: 10.1176/appi.ajp.2020.19111210   
2020 Venkatesh S, Baljinnyam E, Tong M, Kashihara T, Yan L, Liu T, Li H, Xie LH, Nakamura M, Oka S, Suzuki C, Fraidenraich D, Sadoshima J. Proteomic analysis of mitochondrial biogenesis in cardiomyocytes differentiated from human induced pluripotent stem cells. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. PMID 33112656 DOI: 10.1152/ajpregu.00207.2020   
2020 Moreira BP, Silva AM, Martins AD, Monteiro MP, Sousa M, Oliveira PF, Alves MG. Effect of Leptin in Human Sertoli Cells Mitochondrial Physiology. Reproductive Sciences (Thousand Oaks, Calif.). PMID 32997289 DOI: 10.1007/s43032-020-00328-x   
2020 Rai Y, Anita, Kumari N, Singh S, Kalra N, Soni R, Bhatt AN. Mild mitochondrial uncoupling protects from ionizing radiation induced cell death by attenuating oxidative stress and mitochondrial damage. Biochimica Et Biophysica Acta. Bioenergetics. 148325. PMID 33065098 DOI: 10.1016/j.bbabio.2020.148325   
2020 Anand CR, Bhavya B, Jayakumar K, Harikrishnan VS, Gopala S. Inorganic nitrite alters mitochondrial dynamics without overt changes in cell death and mitochondrial respiration in cardiomyoblasts under hyperglycemia. Toxicology in Vitro : An International Journal Published in Association With Bibra. 105048. PMID 33161133 DOI: 10.1016/j.tiv.2020.105048   
2020 Diaz-Juarez J, Suarez JA, DIllmann WH, Suarez J. Mitochondrial Calcium Handling and Heart Disease in Diabetes Mellitus. Biochimica Et Biophysica Acta. Molecular Basis of Disease. 165984. PMID 33002576 DOI: 10.1016/j.bbadis.2020.165984   
2020 Wang F, Roh YS. Mitochondrial connection to ginsenosides. Archives of Pharmacal Research. PMID 33113096 DOI: 10.1007/s12272-020-01279-2   
2020 Lee D, Jo MG, Kim SY, Chung CG, Lee SB. Dietary Antioxidants and the Mitochondrial Quality Control: Their Potential Roles in Parkinson's Disease Treatment. Antioxidants (Basel, Switzerland). 9. PMID 33126703 DOI: 10.3390/antiox9111056   
2020 Neumann MA, Grossmann D, Schimpf-Linzenbold S, Dayan D, Stingl K, Ben-Menachem R, Pines O, Massart F, Delcambre S, Ghelfi J, Bohler J, Strom T, Kessel A, Azem A, Schöls L, et al. Haploinsufficiency due to a novel ACO2 deletion causes mitochondrial dysfunction in fibroblasts from a patient with dominant optic nerve atrophy. Scientific Reports. 10: 16736. PMID 33028849 DOI: 10.1038/s41598-020-73557-4   
2020 Silva-Rodrigues T, de-Souza-Ferreira E, Machado CM, Cabral-Braga B, Rodrigues-Ferreira C, Galina A. Hyperglycemia in a type 1 Diabetes Mellitus model causes a shift in mitochondria coupled-glucose phosphorylation and redox metabolism in rat brain. Free Radical Biology & Medicine. 160: 796-806. PMID 32949665 DOI: 10.1016/j.freeradbiomed.2020.09.017   
2020 Zhao Y, Guo R, Li L, Li S, Fan G, Zhao X, Wang Y. Tongmai formula improves cardiac function via regulating mitochondrial quality control in the myocardium with ischemia/reperfusion injury. Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie. 132: 110897. PMID 33113431 DOI: 10.1016/j.biopha.2020.110897   
2020 Yu X, Sun Y, Cai Q, Zhao X, Liu Z, Xue X, Fu J. Hyperoxia exposure arrests alveolarization in neonatal rats via PTEN‑induced putative kinase 1‑Parkin and Nip3‑like protein X‑mediated mitophagy disorders. International Journal of Molecular Medicine. PMID 33125104 DOI: 10.3892/ijmm.2020.4766