Steven D. Leach - Publications

Affiliations: 
Johns Hopkins University, Baltimore, MD 
Area:
Molecular Biology, Cell Biology

132 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Grimont A, Leach SD, Chandwani R. Uncertain beginnings: acinar and ductal cell plasticity in the development of pancreatic cancer. Cellular and Molecular Gastroenterology and Hepatology. PMID 34352406 DOI: 10.1016/j.jcmgh.2021.07.014  0.36
2020 Escobar-Hoyos LF, Penson A, Kannan R, Cho H, Pan CH, Singh RK, Apken LH, Hobbs GA, Luo R, Lecomte N, Babu S, Pan FC, Alonso-Curbelo D, Morris JP, Askan G, ... ... Leach SD, et al. Altered RNA Splicing by Mutant p53 Activates Oncogenic RAS Signaling in Pancreatic Cancer. Cancer Cell. PMID 32559497 DOI: 10.1016/J.Ccell.2020.05.010  0.336
2020 Latario CJ, Schoenfeld LW, Howarth CL, Pickrell LE, Begum F, Fischer DA, Grbovic-Huezo O, Leach SD, Sanchez Y, Smith KD, Higgs HN. Tumor microtubes connect pancreatic cancer cells in an Arp2/3 complex-dependent manner. Molecular Biology of the Cell. mbcE19110605. PMID 32267199 DOI: 10.1091/Mbc.E19-11-0605  0.389
2020 Moral JA, Leung J, Rojas LA, Ruan J, Zhao J, Sethna Z, Ramnarain A, Gasmi B, Gururajan M, Redmond D, Askan G, Bhanot U, Elyada E, Park Y, Tuveson DA, ... ... Leach SD, et al. ILC2s amplify PD-1 blockade by activating tissue-specific cancer immunity. Nature. PMID 32076273 DOI: 10.1038/S41586-020-2015-4  0.316
2019 Huang YH, Hu J, Chen F, Lecomte N, Basnet H, David CJ, Witkin MD, Allen PJ, Leach SD, Hollmann TJ, Iacobuzio-Donahue CA, Massague J. ID1 mediates escape from TGF-β tumor suppression in pancreatic cancer. Cancer Discovery. PMID 31582374 DOI: 10.1158/2159-8290.Cd-19-0529  0.336
2019 Morris JP, Yashinskie JJ, Koche R, Chandwani R, Tian S, Chen CC, Baslan T, Marinkovic ZS, Sánchez-Rivera FJ, Leach SD, Carmona-Fontaine C, Thompson CB, Finley LWS, Lowe SW. α-Ketoglutarate links p53 to cell fate during tumour suppression. Nature. PMID 31534224 DOI: 10.1038/S41586-019-1577-5  0.381
2019 Luksza M, Leung JP, Solovyov A, Redmond D, Merad M, Gnjatic S, Iacubuzio-Donohue C, DeMatteo RP, Chan TA, Wolchock J, Leach SD, Greenbaum BD, Merghoub T, Balachandran VP. Abstract IA34: Mapping immune recognition of non-self neoantigens in human pancreatic cancer Cancer Immunology Research. 7. DOI: 10.1158/2326-6074.Cricimteatiaacr18-Ia34  0.39
2019 Luksza M, Solovyov A, Vabret N, Balachandran V, Riaz N, Makarov V, Hellmann MD, Snyder A, Funt S, Remark R, Merad M, Gnjatic S, Bajorin DF, Rosenberg J, Leach S, et al. Abstract IA31: Measuring the emergence of non-self in tumors Cancer Immunology Research. 7. DOI: 10.1158/2326-6074.Cricimteatiaacr18-Ia31  0.305
2019 Pan FC, Chong AA, Leach SD, Chen S, Evans T. Abstract C40: Dissecting key biologic processes in pancreatic cancer metastasis using a genetically defined 3D organoid model Cancer Research. 79. DOI: 10.1158/1538-7445.Panca19-C40  0.412
2019 Grimont A, Zhao Z, Leach SD, Chandwani R. Abstract B20: KrasG12D effector dependencies in the maintenance of pancreatic ductal adenocarcinoma Cancer Research. 79. DOI: 10.1158/1538-7445.Panca19-B20  0.38
2019 Leung J, Rojas LA, Ruan J, Zhao J, Gasmi B, Sethna Z, Ramnarain A, Bhanot U, Askan G, Gururajan M, Elyada E, Park Y, Tuveson DA, Gonen M, Leach SD, et al. Abstract B02: Tissue-specific innate lymphoid cells are novel targets for pancreatic cancer immunotherapy Cancer Research. 79. DOI: 10.1158/1538-7445.Panca19-B02  0.376
2018 Park JT, Leach SD. Zebrafish model of -initiated pancreatic cancer. Animal Cells and Systems. 22: 353-359. PMID 30533257 DOI: 10.1080/19768354.2018.1530301  0.452
2018 Zhang Y, Zoltan M, Riquelme E, Xu H, Sahin I, Castro-Pando S, Montiel MF, Chang K, Jiang Z, Ling J, Gupta S, Horne W, Pruski M, Wang H, Sun SC, ... ... Leach SD, et al. Immune Cell Production of Interleukin 17 Induces Stem Cell Features of Pancreatic Intraepithelial Neoplasia Cells. Gastroenterology. PMID 29604293 DOI: 10.1053/J.Gastro.2018.03.041  0.421
2018 Lowery MA, Wong W, Jordan EJ, Lee JW, Kemel Y, Vijai J, Mandelker D, Zehir A, Capanu M, Salo-Mullen E, Arnold AG, Yu KH, Varghese AM, Kelsen DP, Brenner R, ... ... Leach SD, et al. Prospective Evaluation of Germline Alterations in Patients With Exocrine Pancreatic Neoplasms. Journal of the National Cancer Institute. PMID 29506128 DOI: 10.1093/Jnci/Djy024  0.382
2017 Socorro M, Criscimanna A, Riva P, Tandon M, Prasadan K, Guo P, Humar A, Husain SZ, Leach SD, Gittes GK, Esni F. Identification of Newly Committed Pancreatic Cells in the Adult Mouse Pancreas. Scientific Reports. 7: 17539. PMID 29235528 DOI: 10.1038/S41598-017-17884-Z  0.414
2017 Balachandran VP, Łuksza M, Zhao JN, Makarov V, Moral JA, Remark R, Herbst B, Askan G, Bhanot U, Senbabaoglu Y, Wells DK, Cary CIO, Grbovic-Huezo O, Attiyeh M, Medina B, ... ... Leach SD, et al. Identification of unique neoantigen qualities in long-term survivors of pancreatic cancer. Nature. PMID 29132146 DOI: 10.1038/Nature24462  0.363
2017 Mandelker D, Zhang L, Kemel Y, Stadler ZK, Joseph V, Zehir A, Pradhan N, Arnold A, Walsh MF, Li Y, Balakrishnan AR, Syed A, Prasad M, Nafa K, Carlo MI, ... ... Leach SD, et al. Mutation Detection in Patients With Advanced Cancer by Universal Sequencing of Cancer-Related Genes in Tumor and Normal DNA vs Guideline-Based Germline Testing. Jama. 318: 825-835. PMID 28873162 DOI: 10.1001/Jama.2017.11137  0.316
2017 Knudsen E, Vail P, Balaji U, Ngo H, Botros IW, Makarov V, Riaz N, Balachandran VP, Leach SD, Thompson DM, Chan TA, Witkiewicz AK. Stratification of Pancreatic Ductal Adenocarcinoma: Combinatorial Genetic, Stromal, and Immunological Markers. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 28348045 DOI: 10.1158/1078-0432.Ccr-17-0162  0.35
2017 Sinha S, Fu YY, Grimont A, Ketcham M, Lafaro KJ, Saglimbeni JA, Askan G, Bailey JM, Melchor JP, Zhong Y, Joo MG, Grbovic-Huezo O, Yang IH, Basturk O, Baker L, ... ... Leach SD, et al. PanIN neuroendocrine cells promote tumorigenesis via neuronal crosstalk. Cancer Research. PMID 28104683 DOI: 10.1158/0008-5472.Can-16-0899  0.385
2017 Jordan E, Lowery MA, Wong W, Kemel Y, Mukherjee S, Ravichandran V, Basturk O, Yu KH, Iacobuzio-Donahue C, Lincoln A, Varghese AM, Abou-Alfa GK, Leach SD, Klimstra DS, Allen PJ, et al. Prospective assessment for pathogenic germline alterations (PGA) in pancreas cancer (PAC). Journal of Clinical Oncology. 35: 4102-4102. DOI: 10.1200/Jco.2017.35.15_Suppl.4102  0.31
2016 Zhong Y, Macgregor-Das AM, Saunders T, Whittle M, Makohon-Moore A, Kohutek Z, Poling J, Herbst B, Javier B, Cope L, Leach SD, Hingorani SR, Iacobuzio-Donahue CA. Mutant p53 Together with TGFβ Signaling Influence Organ-Specific Hematogenous Colonization Patterns of Pancreatic Cancer. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 27637888 DOI: 10.1158/1078-0432.Ccr-15-1615  0.398
2016 Sinha S, Leach SD. New insights in the development of pancreatic cancer. Current Opinion in Gastroenterology. PMID 27454028 DOI: 10.1097/Mog.0000000000000295  0.388
2016 Perillo M, Wang YJ, Leach SD, Arnone MI. A pancreatic exocrine-like cell regulatory circuit operating in the upper stomach of the sea urchin Strongylocentrotus purpuratus larva. Bmc Evolutionary Biology. 16: 117. PMID 27230062 DOI: 10.1186/S12862-016-0686-0  0.409
2016 Hendley AM, Wang YJ, Polireddy K, Alsina J, Ahmed I, Lafaro KJ, Zhang H, Roy N, Savidge SG, Cao Y, Hebrok M, Maitra A, Reynolds A, Goggins MG, Younes M, ... ... Leach SD, et al. p120 Catenin suppresses basal epithelial cell extrusion in invasive pancreatic neoplasia. Cancer Research. PMID 27032419 DOI: 10.1158/0008-5472.Can-15-2268  0.402
2016 Jordan E, Basturk O, Leach SD, Klimstra DS, Allen PJ, Berger MF, Askan G, Yu KH, O'Reilly EM, Lowery MA. Assessment of genomic alterations in adenosquamous carcinoma of the pancreas (ASCOP). Journal of Clinical Oncology. 34: 261-261. DOI: 10.1200/Jco.2016.34.4_Suppl.261  0.328
2016 Ben-Aharon I, Elkabets M, Pelossof R, Yu KH, Allen PJ, Iacobuzio-Donahue CA, Leach SD, Lowery MA, Goodman KA, O'Reilly EM. Genomic landscape of pancreatic adenocarcinoma: Does age matter? Journal of Clinical Oncology. 34: 250-250. DOI: 10.1200/Jco.2016.34.4_Suppl.250  0.311
2016 Baker LA, Tiriac H, Corbo V, Boj SF, Hwang C, Chio IIC, Engle DD, Jager M, Ponz-Sarvise M, Spector MS, Gracanin A, Oni T, Yu KH, Boxtel Rv, Huch M, ... ... Leach SD, et al. Abstract B16: Using human patient-derived organoids to identify genetic dependencies in pancreatic cancer Clinical Cancer Research. 22. DOI: 10.1158/1557-3265.Pdx16-B16  0.463
2016 Polireddy K, Hendley A, Pruski MA, Lafaro K, Younes M, Maitra A, McAllister F, Iacobuzio-Donahue CA, Dar WA, Bynon JS, Leach SD, Bailey JM. Abstract PR03: Mutant p53 promotes adenocarcinoma in pancreatic ductal cells Cancer Research. 76. DOI: 10.1158/1538-7445.Panca16-Pr03  0.402
2016 Zhang Y, Sahin I, Gupta S, Maitra A, Bailey J, Leach S, McAllister F. Abstract 1447: Influence of IL-17-secreting immune cells in pancreatic cancer stemness Cancer Research. 76: 1447-1447. DOI: 10.1158/1538-7445.Am2016-1447  0.353
2015 Choi E, Hendley AM, Bailey JM, Leach SD, Goldenring JR. Expression of Activated Ras in Gastric Chief Cells of Mice Leads to the Full Spectrum of Metaplastic Lineage Transitions. Gastroenterology. PMID 26677984 DOI: 10.1053/J.Gastro.2015.11.049  0.315
2015 Bailey JM, Hendley AM, Lafaro KJ, Pruski MA, Jones NC, Alsina J, Younes M, Maitra A, McAllister F, Iacobuzio-Donahue CA, Leach SD. p53 mutations cooperate with oncogenic Kras to promote adenocarcinoma from pancreatic ductal cells. Oncogene. PMID 26592447 DOI: 10.1038/Onc.2015.441  0.371
2015 Roeser JC, Leach SD, McAllister F. Emerging strategies for cancer immunoprevention. Oncogene. 34: 6029-6039. PMID 26364615 DOI: 10.1038/Onc.2015.98  0.308
2015 Wang YJ, Park JT, Parsons MJ, Leach SD. Fate mapping of ptf1a-expressing cells during pancreatic organogenesis and regeneration in zebrafish. Developmental Dynamics : An Official Publication of the American Association of Anatomists. 244: 724-35. PMID 25773748 DOI: 10.1002/Dvdy.24271  0.404
2015 Leach SD. Interleukin interrupted: a new strategy for the treatment of pancreatic cancer. The Journal of Experimental Medicine. 212: 284. PMID 25754118 DOI: 10.1084/Jem.2123Insight1  0.361
2015 Boj SF, Hwang CI, Baker LA, Chio II, Engle DD, Corbo V, Jager M, Ponz-Sarvise M, Tiriac H, Spector MS, Gracanin A, Oni T, Yu KH, van Boxtel R, Huch M, ... ... Leach SD, et al. Organoid models of human and mouse ductal pancreatic cancer. Cell. 160: 324-38. PMID 25557080 DOI: 10.1016/J.Cell.2014.12.021  0.435
2015 Hendley AM, Provost E, Bailey JM, Wang YJ, Cleveland MH, Blake D, Bittman RW, Roeser JC, Maitra A, Reynolds AB, Leach SD. p120 Catenin is required for normal tubulogenesis but not epithelial integrity in developing mouse pancreas. Developmental Biology. 399: 41-53. PMID 25523391 DOI: 10.1016/J.Ydbio.2014.12.010  0.383
2015 Park JT, Johnson N, Liu S, Levesque M, Wang YJ, Ho H, Huso D, Maitra A, Parsons MJ, Prescott JD, Leach SD. Differential in vivo tumorigenicity of diverse KRAS mutations in vertebrate pancreas: A comprehensive survey. Oncogene. 34: 2801-6. PMID 25065594 DOI: 10.1038/Onc.2014.223  0.385
2015 Lafaro KJ, Hendley A, Bailey J, Leach S. Abstract PR04: Clonal composition and clonal selection during PanIN progression Cancer Research. 75. DOI: 10.1158/1538-7445.Panca2014-Pr04  0.4
2015 Bailey JM, Alsina J, McAllister F, Hendley A, Lafaro K, Habibulla A, Marchionni L, Maitra A, Leach S. Abstract A10: In search of Kras resistance genes: Whole transcriptome analysis identifies critical pathways mediating resistance and sensitivity to oncogenic Kras Cancer Research. 75. DOI: 10.1158/1538-7445.Panca2014-A10  0.45
2015 Hendley AM, Wang YJ, Alsina J, Ahmed I, Zhang H, Savidge S, Ho H, Reynolds A, Maitra A, Goggins M, Iacobuzio-Donahue C, Leach SD, Bailey JM. Abstract 4186: p120 catenin: A novel regulator of epithelial cell delamination in early Kras-driven pancreatic cancer Cancer Research. 75: 4186-4186. DOI: 10.1158/1538-7445.Am2015-4186  0.466
2014 Wang YJ, McAllister F, Bailey JM, Scott SG, Hendley AM, Leach SD, Ghosh B. Dicer is required for maintenance of adult pancreatic acinar cell identity and plays a role in Kras-driven pancreatic neoplasia. Plos One. 9: e113127. PMID 25405615 DOI: 10.1371/Journal.Pone.0113127  0.435
2014 McAllister F, Leach SD. Targeting IL-17 for pancreatic cancer prevention. Oncotarget. 5: 9530-1. PMID 25393980 DOI: 10.18632/Oncotarget.2618  0.321
2014 Provost E, Bailey JM, Aldrugh S, Liu S, Iacobuzio-Donahue C, Leach SD. The tumor suppressor rpl36 restrains KRAS(G12V)-induced pancreatic cancer. Zebrafish. 11: 551-9. PMID 25380065 DOI: 10.1089/Zeb.2014.1024  0.424
2014 Schiavone M, Rampazzo E, Casari A, Battilana G, Persano L, Moro E, Liu S, Leach SD, Tiso N, Argenton F. Zebrafish reporter lines reveal in vivo signaling pathway activities involved in pancreatic cancer. Disease Models & Mechanisms. 7: 883-94. PMID 24878567 DOI: 10.1242/Dmm.014969  0.449
2014 McAllister F, Bailey JM, Alsina J, Nirschl CJ, Sharma R, Fan H, Rattigan Y, Roeser JC, Lankapalli RH, Zhang H, Jaffee EM, Drake CG, Housseau F, Maitra A, Kolls JK, ... ... Leach SD, et al. Oncogenic Kras activates a hematopoietic-to-epithelial IL-17 signaling axis in preinvasive pancreatic neoplasia. Cancer Cell. 25: 621-37. PMID 24823639 DOI: 10.1016/J.Ccr.2014.03.014  0.34
2014 Minn I, Wang H, Mease RC, Byun Y, Yang X, Wang J, Leach SD, Pomper MG. A red-shifted fluorescent substrate for aldehyde dehydrogenase. Nature Communications. 5: 3662. PMID 24759454 DOI: 10.1038/Ncomms4662  0.31
2014 Bailey JM, Alsina J, Rasheed ZA, McAllister FM, Fu YY, Plentz R, Zhang H, Pasricha PJ, Bardeesy N, Matsui W, Maitra A, Leach SD. DCLK1 marks a morphologically distinct subpopulation of cells with stem cell properties in preinvasive pancreatic cancer. Gastroenterology. 146: 245-56. PMID 24096005 DOI: 10.1053/J.Gastro.2013.09.050  0.482
2014 Hendley AM, Bailey JM, Alsina J, Iacobuzio-Donahue C, Maitra A, Reynolds A, Leach SD. Abstract 66: p120 catenin: A novel regulator of PanIN epithelial cell delamination in preinvasive pancreatic cancer Cancer Research. 74: 66-66. DOI: 10.1158/1538-7445.Am2014-66  0.466
2014 Choi E, Hendley AM, Petersen C, Weis VG, Leach SD, Goldenring JR. 266 Active Kras Leads to Rapid Transdifferentiation of Gastric Chief Cells Into Metaplasia With Progression to Dysplasia and Invasive Cancer Gastroenterology. 146: S-64. DOI: 10.1016/S0016-5085(14)60225-0  0.366
2013 Park JT, Leach SD. TAILOR: transgene activation and inactivation using lox and rox in zebrafish. Plos One. 8: e85218. PMID 24391998 DOI: 10.1371/Journal.Pone.0085218  0.302
2013 Matsuda H, Parsons MJ, Leach SD. Aldh1-expressing endocrine progenitor cells regulate secondary islet formation in larval zebrafish pancreas. Plos One. 8: e74350. PMID 24147152 DOI: 10.1371/Journal.Pone.0074350  0.42
2013 Pashos E, Park JT, Leach S, Fisher S. Distinct enhancers of ptf1a mediate specification and expansion of ventral pancreas in zebrafish. Developmental Biology. 381: 471-81. PMID 23876428 DOI: 10.1016/J.Ydbio.2013.07.011  0.362
2013 Borden P, Houtz J, Leach SD, Kuruvilla R. Sympathetic innervation during development is necessary for pancreatic islet architecture and functional maturation. Cell Reports. 4: 287-301. PMID 23850289 DOI: 10.1016/J.Celrep.2013.06.019  0.318
2013 Provost E, Weier CA, Leach SD. Multiple ribosomal proteins are expressed at high levels in developing zebrafish endoderm and are required for normal exocrine pancreas development. Zebrafish. 10: 161-9. PMID 23697888 DOI: 10.1089/Zeb.2013.0884  0.352
2013 Wang YJ, Bailey JM, Rovira M, Leach SD. Sphere-forming assays for assessment of benign and malignant pancreatic stem cells. Methods in Molecular Biology (Clifton, N.J.). 980: 281-90. PMID 23359160 DOI: 10.1007/978-1-62703-287-2_15  0.39
2013 McAllister F, Bailey JM, Alsina J, Nirschl C, Roeser J, Blake D, Lankapali R, Sears C, Jaffee EM, Kolls J, Drake CG, Pardoll DM, Leach SD. TH17 cells and early pancreatic tumorigenesis. Journal of Clinical Oncology. 31: 144-144. DOI: 10.1200/Jco.2013.31.4_Suppl.144  0.409
2013 McAllister F, Bailey JM, Alsina J, Nirschl C, Lankapalli R, Roeser J, Jaffee E, Sears C, Kolls JK, Drake CG, Pardoll DM, Leach SD. Abstract 2867: TH17 cells promote early pancreatic tumorigenesis. Cancer Research. 73: 2867-2867. DOI: 10.1158/1538-7445.Am2013-2867  0.406
2012 Maitra A, Leach SD. Disputed paternity: the uncertain ancestry of pancreatic ductal neoplasia. Cancer Cell. 22: 701-3. PMID 23238009 DOI: 10.1016/J.Ccr.2012.11.015  0.454
2012 Provost E, Wehner KA, Zhong X, Ashar F, Nguyen E, Green R, Parsons MJ, Leach SD. Ribosomal biogenesis genes play an essential and p53-independent role in zebrafish pancreas development. Development (Cambridge, England). 139: 3232-41. PMID 22872088 DOI: 10.1242/Dev.077107  0.384
2012 Cleveland MH, Sawyer JM, Afelik S, Jensen J, Leach SD. Exocrine ontogenies: on the development of pancreatic acinar, ductal and centroacinar cells. Seminars in Cell & Developmental Biology. 23: 711-9. PMID 22743232 DOI: 10.1016/J.Semcdb.2012.06.008  0.423
2012 Rhim AD, Mirek ET, Aiello NM, Maitra A, Bailey JM, McAllister F, Reichert M, Beatty GL, Rustgi AK, Vonderheide RH, Leach SD, Stanger BZ. EMT and dissemination precede pancreatic tumor formation. Cell. 148: 349-61. PMID 22265420 DOI: 10.1016/J.Cell.2011.11.025  0.47
2012 Gupta S, Maitra A, Ryu J, Zhang N, Bang S, Rovira M, Matthaei H, Hong S, Leach SD, Pan D. Abstract B83: Loss of the Hippo pathway effector Yap disrupts pancreatic morphogenesis and exacerbates exocrine pancreatitis. Cancer Research. 72. DOI: 10.1158/1538-7445.Panca2012-B83  0.453
2012 Bailey JM, Rasheed ZA, McAllister F, Alsina J, Auricchio GM, Maitra A, Hollingsworth MA, Matsui W, Leach SD. Abstract 5338: Pancreatic cancer tumor initiating cells are marked by the presence of cell surface associated acetylated alpha tubulin Cancer Research. 72: 5338-5338. DOI: 10.1158/1538-7445.Am2012-5338  0.422
2012 McAllister F, Bailey JM, Roeser J, Blake DT, Wick EC, Sears CL, Jaffee EM, Kolls JK, Drake CG, Pardoll DM, Leach SD. Abstract 2968: TH17 cells in early pancreatic tumorigenesis Cancer Research. 72: 2968-2968. DOI: 10.1158/1538-7445.Am2012-2968  0.416
2012 Leach S. Modelling pancreatic cancer in mice and zebrafish Pancreatology. 12. DOI: 10.1016/J.Pan.2012.07.005  0.374
2011 Liu S, Leach SD. Screening pancreatic oncogenes in zebrafish using the Gal4/UAS system. Methods in Cell Biology. 105: 367-81. PMID 21951538 DOI: 10.1016/B978-0-12-381320-6.00015-1  0.456
2011 Ghosh B, Leach SD. p53: Guardian of pancreatic epithelial identity. Cell Cycle (Georgetown, Tex.). 10: 1717. PMID 21597331 DOI: 10.4161/Cc.10.11.15686  0.359
2011 Liu S, Leach SD. Zebrafish models for cancer. Annual Review of Pathology. 6: 71-93. PMID 21261518 DOI: 10.1146/Annurev-Pathol-011110-130330  0.34
2011 Bailey JM, Rasheed Z, Matsui W, Maitra A, Hollingsworth MA, Leach SD. Abstract 2449: Pancreatic cancer tumor initiating cells are marked by the presence of a primary cilium Cancer Research. 71: 2449-2449. DOI: 10.1158/1538-7445.Am2011-2449  0.457
2010 Rovira M, Scott SG, Liss AS, Jensen J, Thayer SP, Leach SD. Isolation and characterization of centroacinar/terminal ductal progenitor cells in adult mouse pancreas. Proceedings of the National Academy of Sciences of the United States of America. 107: 75-80. PMID 20018761 DOI: 10.1073/Pnas.0912589107  0.369
2010 Liu S, Parsons MJ, Davison JM, Leach SD. Abstract 4162: Gal4/UAS-mediated pancreatic tumorigenesis in zebrafish Cancer Research. 70: 4162-4162. DOI: 10.1158/1538-7445.Am10-4162  0.445
2009 Wescott MP, Rovira M, Reichert M, von Burstin J, Means A, Leach SD, Rustgi AK. Pancreatic ductal morphogenesis and the Pdx1 homeodomain transcription factor. Molecular Biology of the Cell. 20: 4838-44. PMID 19793922 DOI: 10.1091/Mbc.E09-03-0203  0.426
2009 Parsons MJ, Pisharath H, Yusuff S, Moore JC, Siekmann AF, Lawson N, Leach SD. Notch-responsive cells initiate the secondary transition in larval zebrafish pancreas. Mechanisms of Development. 126: 898-912. PMID 19595765 DOI: 10.1016/J.Mod.2009.07.002  0.415
2009 Burstin Jv, Scott S, Reichert M, Wescott MP, Leach SD, Rustgi AK. 161 A Novel Mouse Model, K19CreERT2; Rosa26R, for the Selective and Specific Marking of Pancreatic Ductal Epithelial Cells Gastroenterology. 136. DOI: 10.1016/S0016-5085(09)60144-X  0.763
2008 Habbe N, Shi G, Meguid RA, Fendrich V, Esni F, Chen H, Feldmann G, Stoffers DA, Konieczny SF, Leach SD, Maitra A. Spontaneous induction of murine pancreatic intraepithelial neoplasia (mPanIN) by acinar cell targeting of oncogenic Kras in adult mice. Proceedings of the National Academy of Sciences of the United States of America. 105: 18913-8. PMID 19028870 DOI: 10.1073/Pnas.0810097105  0.386
2008 Jones S, Zhang X, Parsons DW, Lin JC, Leary RJ, Angenendt P, Mankoo P, Carter H, Kamiyama H, Jimeno A, Hong SM, Fu B, Lin MT, Calhoun ES, Kamiyama M, ... ... Leach SD, et al. Core signaling pathways in human pancreatic cancers revealed by global genomic analyses. Science (New York, N.Y.). 321: 1801-6. PMID 18772397 DOI: 10.1126/Science.1164368  0.39
2008 Halpern ME, Rhee J, Goll MG, Akitake CM, Parsons M, Leach SD. Gal4/UAS transgenic tools and their application to zebrafish. Zebrafish. 5: 97-110. PMID 18554173 DOI: 10.1089/Zeb.2008.0530  0.332
2008 Park SW, Davison JM, Rhee J, Hruban RH, Maitra A, Leach SD. Oncogenic KRAS induces progenitor cell expansion and malignant transformation in zebrafish exocrine pancreas. Gastroenterology. 134: 2080-90. PMID 18549880 DOI: 10.1053/J.Gastro.2008.02.084  0.469
2008 Dong PD, Provost E, Leach SD, Stainier DY. Graded levels of Ptf1a differentially regulate endocrine and exocrine fates in the developing pancreas. Genes & Development. 22: 1445-50. PMID 18519637 DOI: 10.1101/Gad.1663208  0.427
2008 Fendrich V, Esni F, Garay MV, Feldmann G, Habbe N, Jensen JN, Dor Y, Stoffers D, Jensen J, Leach SD, Maitra A. Hedgehog signaling is required for effective regeneration of exocrine pancreas. Gastroenterology. 135: 621-31. PMID 18515092 DOI: 10.1053/J.Gastro.2008.04.011  0.445
2008 Davison JM, Woo Park S, Rhee JM, Leach SD. Characterization of Kras-mediated pancreatic tumorigenesis in zebrafish. Methods in Enzymology. 438: 391-417. PMID 18413263 DOI: 10.1016/S0076-6879(07)38027-0  0.433
2008 Wescott MP, Burstin Jv, Deramaudt TB, Leach SD, Rustgi AK. T1900 Hepatocyte Growth Factor in Concert with PDX-1 Homeodomain Transcription Factor Regulate Pancreatic Ductal Cell Branching Morphogenesis Gastroenterology. 134. DOI: 10.1016/S0016-5085(08)62742-0  0.32
2008 Scott S, Leach SD. Identifying novel targets of Ptf1a using ChIP-on-chip technology Developmental Biology. 319: 593-594. DOI: 10.1016/J.Ydbio.2008.05.502  0.703
2007 Konieczny SF, Leach SD. Metaplastic metamorphoses in the mammalian pancreas. Gastroenterology. 133: 2056-9. PMID 18054579 DOI: 10.1053/J.Gastro.2007.10.061  0.349
2007 Godinho L, Williams PR, Claassen Y, Provost E, Leach SD, Kamermans M, Wong RO. Nonapical symmetric divisions underlie horizontal cell layer formation in the developing retina in vivo. Neuron. 56: 597-603. PMID 18031679 DOI: 10.1016/J.Neuron.2007.09.036  0.306
2007 Biankin SA, Collector MI, Biankin AV, Brown LJ, Kleeberger W, Devereux WL, Zahnow CA, Baylin SB, Watkins DN, Sharkis SJ, Leach SD. A histological survey of green fluorescent protein expression in 'green' mice: implications for stem cell research. Pathology. 39: 247-51. PMID 17454756 DOI: 10.1080/00313020701230807  0.31
2007 Desai BM, Oliver-Krasinski J, De Leon DD, Farzad C, Hong N, Leach SD, Stoffers DA. Preexisting pancreatic acinar cells contribute to acinar cell, but not islet beta cell, regeneration. The Journal of Clinical Investigation. 117: 971-7. PMID 17404620 DOI: 10.1172/Jci29988  0.413
2007 Murtaugh LC, Leach SD. A case of mistaken identity? Nonductal origins of pancreatic "ductal" cancers. Cancer Cell. 11: 211-3. PMID 17349578 DOI: 10.1016/J.Ccr.2007.02.020  0.467
2007 Davison JM, Akitake CM, Goll MG, Rhee JM, Gosse N, Baier H, Halpern ME, Leach SD, Parsons MJ. Transactivation from Gal4-VP16 transgenic insertions for tissue-specific cell labeling and ablation in zebrafish. Developmental Biology. 304: 811-24. PMID 17335798 DOI: 10.1016/J.Ydbio.2007.01.033  0.319
2007 Jarikji ZH, Vanamala S, Beck CW, Wright CV, Leach SD, Horb ME. Differential ability of Ptf1a and Ptf1a-VP16 to convert stomach, duodenum and liver to pancreas. Developmental Biology. 304: 786-99. PMID 17320068 DOI: 10.1016/J.Ydbio.2007.01.027  0.372
2007 Wells JM, Esni F, Boivin GP, Aronow BJ, Stuart W, Combs C, Sklenka A, Leach SD, Lowy AM. Wnt/beta-catenin signaling is required for development of the exocrine pancreas. Bmc Developmental Biology. 7: 4. PMID 17222338 DOI: 10.1186/1471-213X-7-4  0.343
2007 Habbe N, Meguid RA, Fendrich V, Feldmann G, Hruban RH, Leach SD, Maitra A. Spontaneous Development Of Murine Pancreatic Intraepithelial Neoplasia (mpanin) In Ela-creert2; Lsl-kras: Insights Into Cellular Origins Of Pancreatic Cancerg12d: Insights Into Cellular Origins Of Pancreatic Cancer Mice: Insights Into Cellular Origins Of Pancreatic Cancer Pancreas. 35: 405-406. DOI: 10.1097/01.Mpa.0000297711.06220.10  0.436
2007 Dong PDS, Leach S, Stainier DY. ptf1a determines pancreatic exocrine versus endocrine fates Developmental Biology. 306: 416. DOI: 10.1016/J.Ydbio.2007.03.641  0.398
2007 Stainier DY, Dong PDS, Leach S. WITHDRAWN: ptf1a determines pancreatic exocrine versus endocrine fates Developmental Biology. DOI: 10.1016/J.Ydbio.2007.03.294  0.397
2007 Meguid RA, Fendrich V, Esni F, Feldmann G, Maitra A, Leach SD. 35: Sonic Hedgehog misexpression causes expansion of mesenchymal elements in adult mouse pancreas Journal of Surgical Research. 137: 165. DOI: 10.1016/J.Jss.2006.12.044  0.4
2005 Means AL, Meszoely IM, Suzuki K, Miyamoto Y, Rustgi AK, Coffey RJ, Wright CV, Stoffers DA, Leach SD. Pancreatic epithelial plasticity mediated by acinar cell transdifferentiation and generation of nestin-positive intermediates. Development (Cambridge, England). 132: 3767-76. PMID 16020518 DOI: 10.1242/Dev.01925  0.438
2005 Fukushima N, Koopmann J, Sato N, Prasad N, Carvalho R, Leach SD, Hruban RH, Goggins M. Gene expression alterations in the non-neoplastic parenchyma adjacent to infiltrating pancreatic ductal adenocarcinoma. Modern Pathology : An Official Journal of the United States and Canadian Academy of Pathology, Inc. 18: 779-87. PMID 15791284 DOI: 10.1038/Modpathol.3800337  0.433
2005 Leach SD. Epithelial differentiation in pancreatic development and neoplasia: new niches for nestin and Notch. Journal of Clinical Gastroenterology. 39: S78-82. PMID 15758664 DOI: 10.1097/01.Mcg.0000155547.83901.A3  0.414
2005 Prasad NB, Biankin AV, Fukushima N, Maitra A, Dhara S, Elkahloun AG, Hruban RH, Goggins M, Leach SD. Gene expression profiles in pancreatic intraepithelial neoplasia reflect the effects of Hedgehog signaling on pancreatic ductal epithelial cells. Cancer Research. 65: 1619-26. PMID 15753353 DOI: 10.1158/0008-5472.Can-04-1413  0.402
2005 Esni F, Miyamoto Y, Leach SD, Ghosh B. Primary explant cultures of adult and embryonic pancreas. Methods in Molecular Medicine. 103: 259-71. PMID 15542912 DOI: 10.1385/1-59259-780-7:259  0.456
2004 Fukushima N, Sato N, Prasad N, Leach SD, Hruban RH, Goggins M. Characterization of gene expression in mucinous cystic neoplasms of the pancreas using oligonucleotide microarrays. Oncogene. 23: 9042-51. PMID 15489895 DOI: 10.1038/Sj.Onc.1208117  0.372
2004 Esni F, Ghosh B, Biankin AV, Lin JW, Albert MA, Yu X, MacDonald RJ, Civin CI, Real FX, Pack MA, Ball DW, Leach SD. Notch inhibits Ptf1 function and acinar cell differentiation in developing mouse and zebrafish pancreas. Development (Cambridge, England). 131: 4213-24. PMID 15280211 DOI: 10.1242/Dev.01280  0.428
2004 Lin JW, Biankin AV, Horb ME, Ghosh B, Prasad NB, Yee NS, Pack MA, Leach SD. Differential requirement for ptf1a in endocrine and exocrine lineages of developing zebrafish pancreas. Developmental Biology. 270: 474-86. PMID 15183727 DOI: 10.1016/J.Ydbio.2004.02.023  0.37
2004 House MG, Yeo CJ, Cameron JL, Campbell KA, Schulick RD, Leach SD, Hruban RH, Horton KM, Fishman EK, Lillemoe KD. Predicting resectability of periampullary cancer with three-dimensional computed tomography. Journal of Gastrointestinal Surgery : Official Journal of the Society For Surgery of the Alimentary Tract. 8: 280-8. PMID 15019924 DOI: 10.1016/J.Gassur.2003.12.011  0.307
2004 Leach SD. Mouse models of pancreatic cancer: the fur is finally flying! Cancer Cell. 5: 7-11. PMID 14749121 DOI: 10.1016/S1535-6108(03)00337-4  0.457
2004 Esni F, Stoffers DA, Takeuchi T, Leach SD. Origin of exocrine pancreatic cells from nestin-positive precursors in developing mouse pancreas. Mechanisms of Development. 121: 15-25. PMID 14706696 DOI: 10.1016/J.Mod.2003.08.010  0.435
2004 Lin JW, Biankin AV, Horb ME, Ghosh B, Prasad NB, Yee NS, Pack MA, Leach SD. Erratum: Differential requirement for ptf1a in endocrine and exocrine lineages of developing zebrafish pancreas (Developmental Biology (2004) 270 (474-486) DOI: 10.1016/j.ydbio.2004.02.023) Developmental Biology. 274: 490. DOI: 10.1016/J.Ydbio.2004.07.002  0.309
2003 Miyamoto Y, Maitra A, Ghosh B, Zechner U, Argani P, Iacobuzio-Donahue CA, Sriuranpong V, Iso T, Meszoely IM, Wolfe MS, Hruban RH, Ball DW, Schmid RM, Leach SD. Notch mediates TGF alpha-induced changes in epithelial differentiation during pancreatic tumorigenesis. Cancer Cell. 3: 565-76. PMID 12842085 DOI: 10.1016/S1535-6108(03)00140-5  0.436
2003 Hardacre JM, Iacobuzio-Donahue CA, Sohn TA, Abraham SC, Yeo CJ, Lillemoe KD, Choti MA, Campbell KA, Schulick RD, Hruban RH, Cameron JL, Leach SD. Results of pancreaticoduodenectomy for lymphoplasmacytic sclerosing pancreatitis. Annals of Surgery. 237: 853-8; discussion 85. PMID 12796582 DOI: 10.1097/01.Sla.0000071516.54864.C1  0.325
2003 Means AL, Ray KC, Singh AB, Washington MK, Whitehead RH, Harris RC, Wright CV, Coffey RJ, Leach SD. Overexpression of heparin-binding EGF-like growth factor in mouse pancreas results in fibrosis and epithelial metaplasia. Gastroenterology. 124: 1020-36. PMID 12671899 DOI: 10.1053/Gast.2003.50150  0.353
2003 Abraham SC, Leach S, Yeo CJ, Cameron JL, Murakata LA, Boitnott JK, Albores-Saavedra J, Hruban RH. Eosinophilic pancreatitis and increased eosinophils in the pancreas. The American Journal of Surgical Pathology. 27: 334-42. PMID 12604889 DOI: 10.1097/00000478-200303000-00006  0.397
2002 Wagner M, Weber CK, Bressau F, Greten FR, Stagge V, Ebert M, Leach SD, Adler G, Schmid RM. Transgenic overexpression of amphiregulin induces a mitogenic response selectively in pancreatic duct cells. Gastroenterology. 122: 1898-912. PMID 12055597 DOI: 10.1053/Gast.2002.33594  0.336
2002 Crawford HC, Scoggins CR, Washington MK, Matrisian LM, Leach SD. Matrix metalloproteinase-7 is expressed by pancreatic cancer precursors and regulates acinar-to-ductal metaplasia in exocrine pancreas. The Journal of Clinical Investigation. 109: 1437-44. PMID 12045257 DOI: 10.1172/Jci15051  0.378
2001 Means AL, Leach SD. Lineage Commitment and Cellular Differentiation in Exocrine Pancreas Pancreatology. 1: 587-596. PMID 12120241 DOI: 10.1159/000055868  0.433
2000 Scoggins CR, Meszoely IM, Wada M, Means AL, Yang L, Leach SD. p53-dependent acinar cell apoptosis triggers epithelial proliferation in duct-ligated murine pancreas. American Journal of Physiology-Gastrointestinal and Liver Physiology. 279. PMID 11005771 DOI: 10.1152/Ajpgi.2000.279.4.G827  0.372
2000 Song SY, Meszoely IM, Coffey RJ, Pietenpol JA, Leach SD. K-Ras-independent effects of the farnesyl transferase inhibitor L- 744,832 on cyclin B1/Cdc2 kinase activity, G2/M cell cycle progression and apoptosis in human pancreatic ductal adenocarcinoma cells Neoplasia. 2: 261-272. PMID 10935512 DOI: 10.1038/Sj.Neo.7900088  0.344
1999 Song SY, Gannon M, Washington MK, Scoggins CR, Meszoely IM, Goldenring JR, Marino CR, Sandgren EP, Coffey RJ, Wright CV, Leach SD. Expansion of Pdx1-expressing pancreatic epithelium and islet neogenesis in transgenic mice overexpressing transforming growth factor alpha. Gastroenterology. 117: 1416-26. PMID 10579983 DOI: 10.1016/S0016-5085(99)70292-1  0.386
1999 Scoggins CR, Meszoely IM, Blanke CD, Beauchamp RD, Leach SD. Nonoperative management of primary colorectal cancer in patients with stage IV disease. Annals of Surgical Oncology. 6: 651-7. PMID 10560850 DOI: 10.1007/S10434-999-0651-X  0.316
1999 Bold RJ, Charnsangavej C, Cleary KR, Jennings M, Madary A, Leach SD, Abbruzzese JL, Pisters PWT, Lee JE, Evans DB. Major vascular resection as part of pancreaticoduodenectomy for cancer: radiologic, intraoperative, and pathologic analysis☆☆☆ Journal of Gastrointestinal Surgery. 3: 233-243. PMID 10481116 DOI: 10.1016/S1091-255X(99)80065-1  0.319
1998 Leach SD, Lee JE, Charnsangavej C, Cleary KR, Lowy AM, Fenoglio CJ, Pisters PW, Evans DB. Survival following pancreaticoduodenectomy with resection of the superior mesenteric–portal vein confluence for adenocarcinoma of the pancreatic head British Journal of Surgery. 85: 611-617. PMID 9635805 DOI: 10.1046/J.1365-2168.1998.00641.X  0.308
1998 Song SY, Sizemore N, Meszoely I, Coffey RJ, Leach SD. Differential sensitivity of pancreatic cancer cells to farnesyl transferase inhibitor (FTI) correlates with altered subcellular ras distribution and G2/M cell cycle arrest Gastroenterology. 114. DOI: 10.1016/S0016-5085(98)82798-4  0.349
1997 McMasters KM, Tuttle TM, Leach SD, Rich T, Cleary KR, Evans DB, Curley SA. Neoadjuvant chemoradiation for extrahepatic cholangiocarcinoma American Journal of Surgery. 174: 605-609. PMID 9409582 DOI: 10.1016/S0002-9610(97)00203-1  0.305
1997 Leach SD, Blanke CD, Choy H. Pancreatic adenocarcinoma: Adjuvant, neoadjuvant, and intraoperative chemoradiation Seminars in Radiation Oncology. 7: 24-32. DOI: 10.1016/S1053-4296(97)80057-4  0.36
1996 Fuhrman GM, Leach SD, Staley CA, Cusack JC, Charnsangavej C, Cleary KR, El-Naggar AK, Fenoglio CJ, Lee JE, Evans DB. Rationale for En Bloc Vein Resection in the Treatment of Pancreatic Adenocarcinoma Adherent to the Superior Mesenteric-Portal Vein Confluence Annals of Surgery. 223: 154-162. PMID 8597509 DOI: 10.1097/00000658-199602000-00007  0.301
1995 Leach SD, Rose JA, Lowy AM, Lee JE, Charnsangavej C, Abbruzzese JL, Katz RL, Evans DB. Significance of peritoneal cytology in patients with potentially resectable adenocarcinoma of the pancreatic head Surgery. 118: 472-478. PMID 7652681 DOI: 10.1016/S0039-6060(05)80361-7  0.318
1995 Leach S, Lowy A, Fuhrman G, Lee J, Curley S, Evans D. Pancreatic malignancy involving the superior mesenteric-portal vein confluence is not a contraindication to pancreaticoduodenectomy Gastroenterology. 108. DOI: 10.1016/0016-5085(95)29210-1  0.376
1995 Evans DB, Abbruzzese JL, Lee JE, Leach SD, Charnsangavej C, Cleary KR, Buchholz DJ, Rich TA. Preoperative chemoradiation for adenocarcinoma of the pancreas: M.D. Anderson experience Seminars in Surgical Oncology. 11: 132-140. DOI: 10.1002/Ssu.2980110210  0.385
1993 Leach SD, Bilchik AJ, Karapetian O, Gorelick FS, Modlin IM. Influence of chloroquine on diet-induced pancreatitis Pancreas. 8: 64-69. PMID 7678327 DOI: 10.1097/00006676-199301000-00013  0.341
1992 Leach SD, Gorelick FS, Modlin IM. New perspectives on acute pancreatitis Scandinavian Journal of Gastroenterology. 27: 29-38. PMID 1439566 DOI: 10.3109/00365529209095976  0.344
1991 Leach SD, Modlin IM, Scheele GA, Gorelick FS. Intracellular activation of digestive zymogens in rat pancreatic acini stimulation by high doses of cholecystokinin Journal of Clinical Investigation. 87: 362-366. PMID 1985109 DOI: 10.1172/Jci114995  0.323
1990 Leach SD, Gorelick FS, Modlin IM. Acute pancreatitis at its Centenary: The contribution of Reginald Fitz Annals of Surgery. 212: 109-113. PMID 2194439 DOI: 10.1097/00000658-199007000-00014  0.387
1990 Bilchik AJ, Leach SD, Zucker KA, Modlin IM. Experimental models of acute pancreatitis. Journal of Surgical Research. 48: 639-647. PMID 2194073 DOI: 10.1016/0022-4804(90)90245-W  0.399
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