Gokhan S. Hotamisligil, M.D. Ph.D. - Publications

Genetics & Complex Diseases Harvard School of Public Health, Boston, MA, United States 
Obesity, diabetes, metabolic disorders, cell biology

215 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Guney E, Arruda AP, Parlakgul G, Cagampan E, Min N, Lee GY, Greene L, Tsaousidou E, Inouye K, Han MS, Davis RJ, Hotamisligil GS. Aberrant Ca signaling by IPRs in adipocytes links inflammation to metabolic dysregulation in obesity. Science Signaling. 14: eabf2059. PMID 34905386 DOI: 10.1126/scisignal.abf2059  1
2021 Prentice KJ, Saksi J, Robertson LT, Lee GY, Inouye KE, Eguchi K, Lee A, Cakici O, Otterbeck E, Cedillo P, Achenbach P, Ziegler AG, Calay ES, Engin F, Hotamisligil GS. A hormone complex of FABP4 and nucleoside kinases regulates islet function. Nature. PMID 34880500 DOI: 10.1038/s41586-021-04137-3  1
2021 Sethi JK, Hotamisligil GS. Metabolic Messengers: tumour necrosis factor. Nature Metabolism. 3: 1302-1312. PMID 34650277 DOI: 10.1038/s42255-021-00470-z  1
2021 Tirosh A, Tuncman G, Calay ES, Rathaus M, Ron I, Tirosh A, Yalcin A, Lee YG, Livne R, Ron S, Minsky N, Arruda AP, Hotamisligil GS. Intercellular Transmission of Hepatic ER Stress in Obesity Disrupts Systemic Metabolism. Cell Metabolism. 33: 1716. PMID 34348100 DOI: 10.1016/j.cmet.2021.07.005  1
2021 Ristow M, Lee CH, De Bock K, Gladyshev VN, Hotamisligil GS, Manning BD. James R. Mitchell (1971-2020). Cell Metabolism. 33: 458-461. PMID 33657387 DOI: 10.1016/j.cmet.2021.02.009  1
2020 Tirosh A, Tuncman G, Calay ES, Rathaus M, Ron I, Tirosh A, Yalcin A, Lee YG, Livne R, Ron S, Minsky N, Arruda AP, Hotamisligil GS. Intercellular Transmission of Hepatic ER Stress in Obesity Disrupts Systemic Metabolism. Cell Metabolism. PMID 33340456 DOI: 10.1016/j.cmet.2020.11.009  1
2020 Goncalves RLS, Schlame M, Bartelt A, Brand MD, Hotamışlıgil GS. Cardiolipin deficiency in Barth syndrome is not associated with increased superoxide/H O production in heart and skeletal muscle mitochondria. Febs Letters. PMID 33112430 DOI: 10.1002/1873-3468.13973  1
2020 Zhang Z, Qian Q, Li M, Shao F, Ding WX, Lira VA, Chen SX, Sebag SC, Hotamisligil GS, Cao H, Yang L. The Unfolded Protein Response Regulates Hepatic Autophagy by sXBP1-mediated Activation of TFEB. Autophagy. PMID 32597296 DOI: 10.1080/15548627.2020.1788889  1
2019 Liu CL, Ren J, Wang Y, Zhang X, Sukhova GK, Liao M, Santos M, Luo S, Yang D, Xia M, Inouye K, Hotamisligil GS, Lu G, Upchurch GR, Libby P, et al. Adipocytes promote interleukin-18 binding to its receptors during abdominal aortic aneurysm formation in mice. European Heart Journal. PMID 31821481 DOI: 10.1093/Eurheartj/Ehz856  1
2019 Goncalves RLS, Hotamisligil GS. TMEM2 Modulates ER Stress in a Non-canonical Manner. Cell Metabolism. 30: 999-1001. PMID 31801059 DOI: 10.1016/J.Cmet.2019.11.008  1
2019 Leiria LO, Wang CH, Lynes MD, Yang K, Shamsi F, Sato M, Sugimoto S, Chen EY, Bussberg V, Narain NR, Sansbury BE, Darcy J, Huang TL, Kodani SD, Sakaguchi M, ... ... Hotamisligil GS, et al. 12-Lipoxygenase Regulates Cold Adaptation and Glucose Metabolism by Producing the Omega-3 Lipid 12-HEPE from Brown Fat. Cell Metabolism. PMID 31353262 DOI: 10.1016/J.Cmet.2019.07.001  1
2019 Tirosh A, Calay ES, Tuncman G, Claiborn KC, Inouye KE, Eguchi K, Alcala M, Rathaus M, Hollander KS, Ron I, Livne R, Heianza Y, Qi L, Shai I, Garg R, ... Hotamisligil GS, et al. The short-chain fatty acid propionate increases glucagon and FABP4 production, impairing insulin action in mice and humans. Science Translational Medicine. 11. PMID 31019023 DOI: 10.1126/Scitranslmed.Aav0120  1
2019 Prentice KJ, Saksi J, Hotamisligil GS. Adipokine FABP4 integrates energy stores and counter regulatory metabolic responses. Journal of Lipid Research. PMID 30705117 DOI: 10.1194/Jlr.S091793  1
2019 Burak MF, Dagtekin N, Bejo P, Vaillancourt E, Liu L, Gorgun C, Rimm E, Tuncman G, Hotamisligil G. OR01-1 Leveraging Immunometabolic Control to Prevent and Treat Obesity Related Asthma Journal of the Endocrine Society. 3. DOI: 10.1210/Js.2019-Or01-1  1
2018 Liu L, Inouye KE, Allman WR, Coleman AS, Siddiqui S, Hotamisligil GS, Akkoyunlu M. TACI Deficient Macrophages Protect Mice Against Metaflammation and Obesity-Induced Dysregulation of Glucose Homeostasis. Diabetes. PMID 29871859 DOI: 10.2337/Db17-1089  1
2018 Bartelt A, Widenmaier SB, Schlein C, Johann K, Goncalves RLS, Eguchi K, Fischer AW, Parlakgül G, Snyder NA, Nguyen TB, Bruns OT, Franke D, Bawendi MG, Lynes MD, Leiria LO, ... ... Hotamisligil GS, et al. Brown adipose tissue thermogenic adaptation requires Nrf1-mediated proteasomal activity. Nature Medicine. PMID 29400713 DOI: 10.1038/Nm.4481  1
2017 Arruda AP, Pers BM, Parlakgul G, Güney E, Goh T, Cagampan E, Lee GY, Goncalves RL, Hotamisligil GS. Defective STIM-mediated store operated Ca2+ entry in hepatocytes leads to metabolic dysfunction in obesity. Elife. 6. PMID 29243589 DOI: 10.7554/Elife.29968  1
2017 Widenmaier SB, Snyder NA, Nguyen TB, Arduini A, Lee GY, Arruda AP, Saksi J, Bartelt A, Hotamisligil GS. NRF1 Is an ER Membrane Sensor that Is Central to Cholesterol Homeostasis. Cell. 171: 1094-1109.e15. PMID 29149604 DOI: 10.1016/J.Cell.2017.10.003  1
2017 Lynes MD, Leiria LO, Lundh M, Bartelt A, Shamsi F, Huang TL, Takahashi H, Hirshman MF, Schlein C, Lee A, Baer LA, May FJ, Gao F, Narain NR, Chen EY, ... ... Hotamisligil GS, et al. Corrigendum: The cold-induced lipokine 12,13-diHOME promotes fatty acid transport into brown adipose tissue. Nature Medicine. 23: 1384. PMID 29117173 DOI: 10.1038/Nm1117-1384B  1
2017 Charles KN, Li MD, Engin F, Arruda AP, Inouye K, Hotamisligil GS. Uncoupling of Metabolic Health from Longevity through Genetic Alteration of Adipose Tissue Lipid-Binding Proteins. Cell Reports. 21: 393-402. PMID 29020626 DOI: 10.1016/J.Celrep.2017.09.051  1
2017 Hotamisligil GS. Foundations of Immunometabolism and Implications for Metabolic Health and Disease. Immunity. 47: 406-420. PMID 28930657 DOI: 10.1016/J.Immuni.2017.08.009  0.01
2017 Garfinkel BP, Hotamisligil GS. ER Stress Promotes Inflammation through Re-wIREd Macrophages in Obesity. Molecular Cell. 66: 731-733. PMID 28622517 DOI: 10.1016/J.Molcel.2017.05.037  0.01
2017 Parlakgul G, Hotamisligil GS. Type I Interferons Interfere with Liver Glucose Metabolism. Cell Metabolism. 25: 1211-1212. PMID 28591628 DOI: 10.1016/J.Cmet.2017.05.009  1
2017 Pan Y, Tian T, Park CO, Lofftus SY, Mei S, Liu X, Luo C, O'Malley JT, Gehad A, Teague JE, Divito SJ, Fuhlbrigge R, Puigserver P, Krueger JG, Hotamisligil GS, et al. Survival of tissue-resident memory T cells requires exogenous lipid uptake and metabolism. Nature. PMID 28219080 DOI: 10.1038/Nature21379  1
2017 Hotamisligil GS. Inflammation, metaflammation and immunometabolic disorders. Nature. 542: 177-185. PMID 28179656 DOI: 10.1038/Nature21363  0.01
2016 Widenmaier SB, Hotamışlıgil GS. Immune Cell Intolerance for Excess Cholesterol. Immunity. 45: 1186-1188. PMID 28002726 DOI: 10.1016/J.Immuni.2016.12.006  1
2016 Hotamisligil GS, Davis RJ. Cell Signaling and Stress Responses. Cold Spring Harbor Perspectives in Biology. 8. PMID 27698029 DOI: 10.1101/Cshperspect.A006072  1
2016 Çimen I, Kocatürk B, Koyuncu S, Tufanlı Ö, Onat UI, Yıldırım AD, Apaydın O, Demirsoy Ş, Aykut ZG, Nguyen UT, Watkins SM, Hotamışlıgil GS, Erbay E. Prevention of atherosclerosis by bioactive palmitoleate through suppression of organelle stress and inflammasome activation. Science Translational Medicine. 8: 358ra126. PMID 27683551 DOI: 10.1126/Scitranslmed.Aaf9087  1
2016 Erikci Ertunc M, Hotamisligil GS. Lipid signaling and lipotoxicity in metabolic inflammation: indications for metabolic disease pathogenesis and treatment. Journal of Lipid Research. PMID 27330055 DOI: 10.1194/Jlr.R066514  0.01
2016 Yilmaz M, Claiborn KC, Hotamisligil GS. De Novo Lipogenesis Products and Endogenous Lipokines. Diabetes. PMID 27288005 DOI: 10.2337/Db16-0251  1
2016 Babaev VR, Yeung M, Erbay E, Ding L, Zhang Y, May JM, Fazio S, Hotamisligil GS, Linton MF. Jnk1 Deficiency in Hematopoietic Cells Suppresses Macrophage Apoptosis and Increases Atherosclerosis in Low-Density Lipoprotein Receptor Null Mice. Arteriosclerosis, Thrombosis, and Vascular Biology. PMID 27102962 DOI: 10.1161/Atvbaha.116.307580  1
2016 Yang L, Licastro D, Cava E, Veronese N, Spelta F, Rizza W, Bertozzi B, Villareal DT, Hotamisligil GS, Holloszy JO, Fontana L. Long-Term Calorie Restriction Enhances Cellular Quality-Control Processes in Human Skeletal Muscle. Cell Reports. PMID 26774472 DOI: 10.1016/J.Celrep.2015.12.042  1
2015 Burak MF, Inouye KE, White A, Lee A, Tuncman G, Calay ES, Sekiya M, Tirosh A, Eguchi K, Birrane G, Lightwood D, Howells L, Odede G, Hailu H, West S, ... ... Hotamisligil GS, et al. Development of a therapeutic monoclonal antibody that targets secreted fatty acid-binding protein aP2 to treat type 2 diabetes. Science Translational Medicine. 7: 319ra205. PMID 26702093 DOI: 10.1126/Scitranslmed.Aac6336  1
2015 Yu CW, Liang X, Lipsky S, Karaaslan C, Kozakewich H, Hotamisligil GS, Bischoff J, Cataltepe S. Dual role of fatty acid-binding protein 5 on endothelial cell fate: a potential link between lipid metabolism and angiogenic responses. Angiogenesis. PMID 26625874 DOI: 10.1007/S10456-015-9491-4  1
2015 Zhou Y, Yu X, Chen H, Sjöberg S, Roux J, Zhang L, Ivoulsou AH, Bensaid F, Liu CL, Liu J, Tordjman J, Clement K, Lee CH, Hotamisligil GS, Libby P, et al. Leptin Deficiency Shifts Mast Cells toward Anti-Inflammatory Actions and Protects Mice from Obesity and Diabetes by Polarizing M2 Macrophages. Cell Metabolism. PMID 26481668 DOI: 10.1016/J.Cmet.2015.09.013  1
2015 Hotamisligil GS, Bernlohr DA. Metabolic functions of FABPs-mechanisms and therapeutic implications. Nature Reviews. Endocrinology. 11: 592-605. PMID 26260145 DOI: 10.1038/Nrendo.2015.122  1
2015 Yang L, Calay ES, Fan J, Arduini A, Kunz RC, Gygi SP, Yalcin A, Fu S, Hotamisligil GS. METABOLISM. S-Nitrosylation links obesity-associated inflammation to endoplasmic reticulum dysfunction. Science (New York, N.Y.). 349: 500-6. PMID 26228140 DOI: 10.1126/Science.Aaa0079  1
2015 Arruda AP, Hotamisligil GS. Calcium Homeostasis and Organelle Function in the Pathogenesis of Obesity and Diabetes. Cell Metabolism. 22: 381-97. PMID 26190652 DOI: 10.1016/J.Cmet.2015.06.010  1
2015 Brozzi F, Nardelli TR, Lopes M, Millard I, Barthson J, Igoillo-Esteve M, Grieco FA, Villate O, Oliveira JM, Casimir M, Bugliani M, Engin F, Hotamisligil GS, Marchetti P, Eizirik DL. Cytokines induce endoplasmic reticulum stress in human, rat and mouse beta cells via different mechanisms. Diabetologia. 58: 2307-16. PMID 26099855 DOI: 10.1007/S00125-015-3669-6  1
2015 Fu S, Yalcin A, Lee GY, Li P, Fan J, Arruda AP, Pers BM, Yilmaz M, Eguchi K, Hotamisligil GS. Phenotypic assays identify azoramide as a small-molecule modulator of the unfolded protein response with antidiabetic activity. Science Translational Medicine. 7: 292ra98. PMID 26084805 DOI: 10.1126/Scitranslmed.Aaa9134  1
2015 Sheng X, Arnoldussen YJ, Storm M, Tesikova M, Nenseth HZ, Zhao S, Fazli L, Rennie P, Risberg B, Wæhre H, Danielsen H, Mills IG, Jin Y, Hotamisligil G, Saatcioglu F. Divergent androgen regulation of unfolded protein response pathways drives prostate cancer. Embo Molecular Medicine. 7: 788-801. PMID 25864123 DOI: 10.15252/Emmm.201404509  1
2015 Youssef OA, Safran SA, Nakamura T, Nix DA, Hotamisligil GS, Bass BL. Potential role for snoRNAs in PKR activation during metabolic stress. Proceedings of the National Academy of Sciences of the United States of America. 112: 5023-8. PMID 25848059 DOI: 10.1073/Pnas.1424044112  1
2015 Nakamura T, Kunz RC, Zhang C, Kimura T, Yuan CL, Baccaro B, Namiki Y, Gygi SP, Hotamisligil GS. A critical role for PKR complexes with TRBP in Immunometabolic regulation and eIF2α phosphorylation in obesity. Cell Reports. 11: 295-307. PMID 25843719 DOI: 10.1016/J.Celrep.2015.03.021  1
2015 Ertunc ME, Sikkeland J, Fenaroli F, Griffiths G, Daniels MP, Cao H, Saatcioglu F, Hotamisligil GS. Secretion of fatty acid binding protein aP2 from adipocytes through a nonclassical pathway in response to adipocyte lipase activity. Journal of Lipid Research. 56: 423-34. PMID 25535287 DOI: 10.1194/Jlr.M055798  1
2014 Arruda AP, Pers BM, Parlakgül G, Güney E, Inouye K, Hotamisligil GS. Chronic enrichment of hepatic endoplasmic reticulum-mitochondria contact leads to mitochondrial dysfunction in obesity. Nature Medicine. 20: 1427-35. PMID 25419710 DOI: 10.1038/Nm.3735  1
2014 Zhang Y, Nicholatos J, Dreier JR, Ricoult SJ, Widenmaier SB, Hotamisligil GS, Kwiatkowski DJ, Manning BD. Coordinated regulation of protein synthesis and degradation by mTORC1. Nature. 513: 440-3. PMID 25043031 DOI: 10.1038/Nature13492  1
2014 Saint-Geniez M, Ghelfi E, Liang X, Yu C, Spencer C, Abend S, Hotamisligil G, Cataltepe S. Fatty acid binding protein 4 deficiency protects against oxygen-induced retinopathy in mice. Plos One. 9: e96253. PMID 24802082 DOI: 10.1371/Journal.Pone.0096253  1
2014 Nair KS, Abel ED, Adler SG, Dyck PJ, Gardner TW, Haskins KM, Hotamisligil G, Jensen MD, Krook A, Mandarino LJ, Mitchell BD, Pessin JE, Sowers JR, Sussel L, Wareham N, et al. Time to look back and to look forward. Diabetes. 63: 1169-70. PMID 24651796 DOI: 10.2337/Db14-0067  1
2014 Engin F, Nguyen T, Yermalovich A, Hotamisligil GS. Aberrant islet unfolded protein response in type 2 diabetes. Scientific Reports. 4: 4054. PMID 24514745 DOI: 10.1038/Srep04054  1
2014 Garin-Shkolnik T, Rudich A, Hotamisligil GS, Rubinstein M. FABP4 attenuates PPARγ and adipogenesis and is inversely correlated with PPARγ in adipose tissues. Diabetes. 63: 900-11. PMID 24319114 DOI: 10.2337/Db13-0436  1
2014 Nakamura T, Arduini A, Baccaro B, Furuhashi M, Hotamisligil GS. Small-molecule inhibitors of PKR improve glucose homeostasis in obese diabetic mice. Diabetes. 63: 526-34. PMID 24150608 DOI: 10.2337/Db13-1019  1
2013 Syamsunarno MR, Iso T, Hanaoka H, Yamaguchi A, Obokata M, Koitabashi N, Goto K, Hishiki T, Nagahata Y, Matsui H, Sano M, Kobayashi M, Kikuchi O, Sasaki T, Maeda K, ... ... Hotamisligil GS, et al. A critical role of fatty acid binding protein 4 and 5 (FABP4/5) in the systemic response to fasting. Plos One. 8: e79386. PMID 24244493 DOI: 10.1371/Journal.Pone.0079386  1
2013 Engin F, Yermalovich A, Nguyen T, Ngyuen T, Hummasti S, Fu W, Eizirik DL, Mathis D, Hotamisligil GS. Restoration of the unfolded protein response in pancreatic β cells protects mice against type 1 diabetes. Science Translational Medicine. 5: 211ra156. PMID 24225943 DOI: 10.1126/Scitranslmed.3006534  1
2013 Liu S, Brown JD, Stanya KJ, Homan E, Leidl M, Inouye K, Bhargava P, Gangl MR, Dai L, Hatano B, Hotamisligil GS, Saghatelian A, Plutzky J, Lee CH. A diurnal serum lipid integrates hepatic lipogenesis and peripheral fatty acid use. Nature. 502: 550-4. PMID 24153306 DOI: 10.1038/Nature12710  1
2013 Iso T, Maeda K, Hanaoka H, Suga T, Goto K, Syamsunarno MR, Hishiki T, Nagahata Y, Matsui H, Arai M, Yamaguchi A, Abumrad NA, Sano M, Suematsu M, Endo K, ... Hotamisligil GS, et al. Capillary endothelial fatty acid binding proteins 4 and 5 play a critical role in fatty acid uptake in heart and skeletal muscle. Arteriosclerosis, Thrombosis, and Vascular Biology. 33: 2549-57. PMID 23968980 DOI: 10.1161/ATVBAHA.113.301588  1
2013 Cao H, Sekiya M, Ertunc ME, Burak MF, Mayers JR, White A, Inouye K, Rickey LM, Ercal BC, Furuhashi M, Tuncman G, Hotamisligil GS. Adipocyte lipid chaperone AP2 is a secreted adipokine regulating hepatic glucose production. Cell Metabolism. 17: 768-78. PMID 23663740 DOI: 10.1016/J.Cmet.2013.04.012  1
2013 Gregor MF, Misch ES, Yang L, Hummasti S, Inouye KE, Lee AH, Bierie B, Hotamisligil GS. The role of adipocyte XBP1 in metabolic regulation during lactation. Cell Reports. 3: 1430-9. PMID 23623498 DOI: 10.1016/J.Celrep.2013.03.042  1
2013 Calay ES, Hotamisligil GS. Turning off the inflammatory, but not the metabolic, flames. Nature Medicine. 19: 265-7. PMID 23467233 DOI: 10.1038/Nm.3114  1
2013 Yalcin A, Hotamisligil GS. Impact of ER protein homeostasis on metabolism. Diabetes. 62: 691-3. PMID 23431011 DOI: 10.2337/Db12-1526  1
2013 Mozaffarian D, De Oliveira Otto MC, Lemaitre RN, Fretts AM, Hotamisligil G, Tsai MY, Siscovick DS, Nettleton JA. Trans-Palmitoleic acid, other dairy fat biomarkers, and incident diabetes: The multi-ethnic study of atherosclerosis (MESA) American Journal of Clinical Nutrition. 97: 854-861. PMID 23407305 DOI: 10.3945/Ajcn.112.045468  1
2013 Ghelfi E, Yu CW, Elmasri H, Terwelp M, Lee CG, Bhandari V, Comhair SA, Erzurum SC, Hotamisligil GS, Elias JA, Cataltepe S. Fatty acid binding protein 4 regulates VEGF-induced airway angiogenesis and inflammation in a transgenic mouse model: implications for asthma. The American Journal of Pathology. 182: 1425-33. PMID 23391391 DOI: 10.1016/J.Ajpath.2012.12.009  1
2013 Yilmaz M, Hotamisligil GS. Damned if you do, damned if you don't: the conundrum of adipose tissue vascularization. Cell Metabolism. 17: 7-9. PMID 23312279 DOI: 10.1016/J.Cmet.2012.12.014  1
2013 Hotamisligil GS, Überall F. Nutrient sensing and inflammation in metabolic diseases | Bereits nach 5 Jahren ein Klassiker: Das Review zur Metainflammation Forschende Komplementarmedizin. 20: 232-233. DOI: 10.1159/000353669  1
2013 Engin F, Yermalovich A, Nguyen T, Hummasti S, Fu W, Eizirik DL, Mathis D, Hotamisligil GS. Restoration of the unfolded protein response in pancreatic β cells protects mice against type 1 diabetes (Science Translational Medicine (2013) 5, (211ra156)) Science Translational Medicine. 5. DOI: 10.1126/scitranslmed.3008086  1
2012 Klionsky DJ, Abdalla FC, Abeliovich H, Abraham RT, Acevedo-Arozena A, Adeli K, Agholme L, Agnello M, Agostinis P, Aguirre-Ghiso JA, Ahn HJ, Ait-Mohamed O, Ait-Si-Ali S, Akematsu T, Akira S, ... ... Hotamisligil GS, et al. Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy. 8: 445-544. PMID 22966490 DOI: 10.4161/Auto.19496  0.01
2012 Fu S, Fan J, Blanco J, Gimenez-Cassina A, Danial NN, Watkins SM, Hotamisligil GS. Polysome profiling in liver identifies dynamic regulation of endoplasmic reticulum translatome by obesity and fasting. Plos Genetics. 8: e1002902. PMID 22927828 DOI: 10.1371/Journal.Pgen.1002902  1
2012 Watkins SM, Hotamisligil GS. Promoting atherosclerosis in type 1 diabetes through the selective activation of arachidonic acid and PGE(2) production. Circulation Research. 111: 394-6. PMID 22859668 DOI: 10.1161/CIRCRESAHA.112.273508  1
2012 Lu B, Nakamura T, Inouye K, Li J, Tang Y, Lundbäck P, Valdes-Ferrer SI, Olofsson PS, Kalb T, Roth J, Zou Y, Erlandsson-Harris H, Yang H, Ting JP, Wang H, ... ... Hotamisligil GS, et al. Novel role of PKR in inflammasome activation and HMGB1 release. Nature. 488: 670-4. PMID 22801494 DOI: 10.1038/Nature11290  1
2012 ten Freyhaus H, Calay ES, Yalcin A, Vallerie SN, Yang L, Calay ZZ, Saatcioglu F, Hotamisligil GS. Stamp2 controls macrophage inflammation through nicotinamide adenine dinucleotide phosphate homeostasis and protects against atherosclerosis. Cell Metabolism. 16: 81-9. PMID 22704678 DOI: 10.1016/J.Cmet.2012.05.009  1
2012 Fukuda D, Aikawa E, Swirski FK, Novobrantseva TI, Kotelianski V, Gorgun CZ, Chudnovskiy A, Yamazaki H, Croce K, Weissleder R, Aster JC, Hotamisligil GS, Yagita H, Aikawa M. Notch ligand delta-like 4 blockade attenuates atherosclerosis and metabolic disorders. Proceedings of the National Academy of Sciences of the United States of America. 109: E1868-77. PMID 22699504 DOI: 10.1073/Pnas.1116889109  1
2012 Elmasri H, Ghelfi E, Yu CW, Traphagen S, Cernadas M, Cao H, Shi GP, Plutzky J, Sahin M, Hotamisligil G, Cataltepe S. Endothelial cell-fatty acid binding protein 4 promotes angiogenesis: Role of stem cell factor/c-kit pathway Angiogenesis. 15: 457-468. PMID 22562362 DOI: 10.1007/S10456-012-9274-0  1
2012 Fu S, Watkins SM, Hotamisligil GS. The role of endoplasmic reticulum in hepatic lipid homeostasis and stress signaling. Cell Metabolism. 15: 623-34. PMID 22560215 DOI: 10.1016/J.Cmet.2012.03.007  1
2012 Oh RS, Pan WC, Yalcin A, Zhang H, Guilarte TR, Hotamisligil GS, Christiani DC, Lu Q. Functional RNA interference (RNAi) screen identifies system A neutral amino acid transporter 2 (SNAT2) as a mediator of arsenic-induced endoplasmic reticulum stress. The Journal of Biological Chemistry. 287: 6025-34. PMID 22215663 DOI: 10.1074/Jbc.M111.311217  1
2012 Bechmann LP, Hannivoort RA, Gerken G, Hotamisligil GS, Trauner M, Canbay A. The interaction of hepatic lipid and glucose metabolism in liver diseases. Journal of Hepatology. 56: 952-64. PMID 22173168 DOI: 10.1016/j.jhep.2011.08.025  1
2011 Furuhashi M, Ishimura S, Ota H, Hayashi M, Nishitani T, Tanaka M, Yoshida H, Shimamoto K, Hotamisligil GS, Miura T. Serum fatty acid-binding protein 4 is a predictor of cardiovascular events in end-stage renal disease. Plos One. 6: e27356. PMID 22102888 DOI: 10.1371/Journal.Pone.0027356  1
2011 Nieman KM, Kenny HA, Penicka CV, Ladanyi A, Buell-Gutbrod R, Zillhardt MR, Romero IL, Carey MS, Mills GB, Hotamisligil GS, Yamada SD, Peter ME, Gwin K, Lengyel E. Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth. Nature Medicine. 17: 1498-503. PMID 22037646 DOI: 10.1038/Nm.2492  1
2011 Yecies JL, Zhang HH, Menon S, Liu S, Yecies D, Lipovsky AI, Gorgun C, Kwiatkowski DJ, Hotamisligil GS, Lee CH, Manning BD. Akt stimulates hepatic SREBP1c and lipogenesis through parallel mTORC1-dependent and independent pathways. Cell Metabolism. 14: 21-32. PMID 21723501 DOI: 10.1016/J.Cmet.2011.06.002  1
2011 Lee AH, Heidtman K, Hotamisligil GS, Glimcher LH. Dual and opposing roles of the unfolded protein response regulated by IRE1alpha and XBP1 in proinsulin processing and insulin secretion. Proceedings of the National Academy of Sciences of the United States of America. 108: 8885-90. PMID 21555585 DOI: 10.1073/Pnas.1105564108  1
2011 Fu S, Yang L, Li P, Hofmann O, Dicker L, Hide W, Lin X, Watkins SM, Ivanov AR, Hotamisligil GS. Aberrant lipid metabolism disrupts calcium homeostasis causing liver endoplasmic reticulum stress in obesity. Nature. 473: 528-31. PMID 21532591 DOI: 10.1038/nature09968  1
2011 Babaev VR, Runner RP, Fan D, Ding L, Zhang Y, Tao H, Erbay E, Görgün CZ, Fazio S, Hotamisligil GS, Linton MF. Macrophage Mal1 deficiency suppresses atherosclerosis in low-density lipoprotein receptor-null mice by activating peroxisome proliferator-activated receptor-γ-regulated genes. Arteriosclerosis, Thrombosis, and Vascular Biology. 31: 1283-90. PMID 21474828 DOI: 10.1161/Atvbaha.111.225839  1
2011 Horng T, Hotamisligil GS. Linking the inflammasome to obesity-related disease. Nature Medicine. 17: 164-5. PMID 21297609 DOI: 10.1038/Nm0211-164  1
2011 Gregor MF, Hotamisligil GS. Inflammatory mechanisms in obesity. Annual Review of Immunology. 29: 415-45. PMID 21219177 DOI: 10.1146/Annurev-Immunol-031210-101322  1
2010 Mozaffarian D, Cao H, King IB, Lemaitre RN, Song X, Siscovick DS, Hotamisligil GS. Trans-palmitoleic acid, metabolic risk factors, and new-onset diabetes in U.S. adults: a cohort study. Annals of Internal Medicine. 153: 790-9. PMID 21173413 DOI: 10.7326/0003-4819-153-12-201012210-00005  1
2010 Vallerie SN, Hotamisligil GS. The role of JNK proteins in metabolism. Science Translational Medicine. 2: 60rv5. PMID 21123811 DOI: 10.1126/Scitranslmed.3001007  1
2010 Engin F, Hotamisligil GS. Restoring endoplasmic reticulum function by chemical chaperones: an emerging therapeutic approach for metabolic diseases. Diabetes, Obesity & Metabolism. 12: 108-15. PMID 21029307 DOI: 10.1111/J.1463-1326.2010.01282.X  1
2010 Mozaffarian D, Cao H, King IB, Lemaitre RN, Song X, Siscovick DS, Hotamisligil GS. Circulating palmitoleic acid and risk of metabolic abnormalities and new-onset diabetes. The American Journal of Clinical Nutrition. 92: 1350-8. PMID 20943795 DOI: 10.3945/Ajcn.110.003970  1
2010 Hummasti S, Hotamisligil GS. Endoplasmic reticulum stress and inflammation in obesity and diabetes. Circulation Research. 107: 579-91. PMID 20814028 DOI: 10.1161/Circresaha.110.225698  1
2010 Kars M, Yang L, Gregor MF, Mohammed BS, Pietka TA, Finck BN, Patterson BW, Horton JD, Mittendorfer B, Hotamisligil GS, Klein S. Tauroursodeoxycholic Acid may improve liver and muscle but not adipose tissue insulin sensitivity in obese men and women. Diabetes. 59: 1899-905. PMID 20522594 DOI: 10.2337/Db10-0308  1
2010 Yang L, Li P, Fu S, Calay ES, Hotamisligil GS. Defective hepatic autophagy in obesity promotes ER stress and causes insulin resistance. Cell Metabolism. 11: 467-78. PMID 20519119 DOI: 10.1016/J.Cmet.2010.04.005  1
2010 Li P, Hotamisligil GS. Metabolism: Host and microbes in a pickle. Nature. 464: 1287-8. PMID 20428156 DOI: 10.1038/4641287A  1
2010 Hotamisligil GS. Endoplasmic reticulum stress and atherosclerosis. Nature Medicine. 16: 396-9. PMID 20376052 DOI: 10.1038/Nm0410-396  1
2010 Hotamisligil GS. Endoplasmic reticulum stress and the inflammatory basis of metabolic disease. Cell. 140: 900-17. PMID 20303879 DOI: 10.1016/J.Cell.2010.02.034  1
2010 Nakamura T, Furuhashi M, Li P, Cao H, Tuncman G, Sonenberg N, Gorgun CZ, Hotamisligil GS. Double-stranded RNA-dependent protein kinase links pathogen sensing with stress and metabolic homeostasis. Cell. 140: 338-48. PMID 20144759 DOI: 10.1016/J.Cell.2010.01.001  1
2010 Mozaffarian D, Cao H, King IB, Lemaitre RN, Song X, Siscovick DS, Hotamisligil GS. Trans-Palmitoleic Acid, Metabolic Risk Factors, and New-Onset Diabetes in U.S. Adults Annals of Internal Medicine. 153: 790-799. DOI: 10.1059/0003-4819-153-12-201012210-00005  1
2009 Erbay E, Babaev VR, Mayers JR, Makowski L, Charles KN, Snitow ME, Fazio S, Wiest MM, Watkins SM, Linton MF, Hotamisligil GS. Reducing endoplasmic reticulum stress through a macrophage lipid chaperone alleviates atherosclerosis. Nature Medicine. 15: 1383-91. PMID 19966778 DOI: 10.1038/Nm.2067  1
2009 Liu J, Divoux A, Sun J, Zhang J, Clément K, Glickman JN, Sukhova GK, Wolters PJ, Du J, Gorgun CZ, Doria A, Libby P, Blumberg RS, Kahn BB, Hotamisligil GS, et al. Genetic deficiency and pharmacological stabilization of mast cells reduce diet-induced obesity and diabetes in mice. Nature Medicine. 15: 940-5. PMID 19633655 DOI: 10.1038/Nm.1994  1
2009 Chavey C, Lazennec G, Lagarrigue S, Clapé C, Iankova I, Teyssier J, Annicotte JS, Schmidt J, Mataki C, Yamamoto H, Sanches R, Guma A, Stich V, Vitkova M, Jardin-Watelet B, ... ... Hotamisligil GS, et al. CXC ligand 5 is an adipose-tissue derived factor that links obesity to insulin resistance. Cell Metabolism. 9: 339-49. PMID 19356715 DOI: 10.1016/J.Cmet.2009.03.002  1
2009 Gregor MF, Yang L, Fabbrini E, Mohammed BS, Eagon JC, Hotamisligil GS, Klein S. Endoplasmic reticulum stress is reduced in tissues of obese subjects after weight loss. Diabetes. 58: 693-700. PMID 19066313 DOI: 10.2337/Db08-1220  1
2009 Peraldi P, Hotamisligil GS, Buurman WA, White M, Spiegelman BM. O-47: Mechanisms of TNF-α induced insulin resistance Experimental and Clinical Endocrinology & Diabetes. 104: 59-59. DOI: 10.1055/s-0029-1211538  0.32
2008 Hotamisligil GS. Inflammation and endoplasmic reticulum stress in obesity and diabetes. International Journal of Obesity (2005). 32: S52-4. PMID 19136991 DOI: 10.1038/Ijo.2008.238  1
2008 Hotamisligil GS, Erbay E. Nutrient sensing and inflammation in metabolic diseases. Nature Reviews. Immunology. 8: 923-34. PMID 19029988 DOI: 10.1038/Nri2449  1
2008 Yang L, Hotamisligil GS. Stressing the brain, fattening the body. Cell. 135: 20-2. PMID 18854151 DOI: 10.1016/J.Cell.2008.09.030  1
2008 Cao H, Gerhold K, Mayers JR, Wiest MM, Watkins SM, Hotamisligil GS. Identification of a lipokine, a lipid hormone linking adipose tissue to systemic metabolism. Cell. 134: 933-44. PMID 18805087 DOI: 10.1016/J.Cell.2008.07.048  1
2008 Vallerie SN, Furuhashi M, Fucho R, Hotamisligil GS. A predominant role for parenchymal c-Jun amino terminal kinase (JNK) in the regulation of systemic insulin sensitivity. Plos One. 3: e3151. PMID 18773087 DOI: 10.1371/Journal.Pone.0003151  1
2008 Furuhashi M, Fucho R, Görgün CZ, Tuncman G, Cao H, Hotamisligil GS. Adipocyte/macrophage fatty acid-binding proteins contribute to metabolic deterioration through actions in both macrophages and adipocytes in mice. The Journal of Clinical Investigation. 118: 2640-50. PMID 18551191 DOI: 10.1172/Jci34750  1
2008 Furuhashi M, Hotamisligil GS. Fatty acid-binding proteins: role in metabolic diseases and potential as drug targets. Nature Reviews. Drug Discovery. 7: 489-503. PMID 18511927 DOI: 10.1038/Nrd2589  1
2008 Ozcan U, Ozcan L, Yilmaz E, Düvel K, Sahin M, Manning BD, Hotamisligil GS. Loss of the tuberous sclerosis complex tumor suppressors triggers the unfolded protein response to regulate insulin signaling and apoptosis. Molecular Cell. 29: 541-51. PMID 18342602 DOI: 10.1016/J.Molcel.2007.12.023  1
2007 Hotamisligil GS. Endoplasmic reticulum stress and inflammation in obesity and type 2 diabetes. Novartis Foundation Symposium. 286: 86-94; discussion 94. PMID 18269176 DOI: 10.1002/9780470985571.Ch8  1
2007 Erbay E, Cao H, Hotamisligil GS. Adipocyte/macrophage fatty acid binding proteins in metabolic syndrome. Current Atherosclerosis Reports. 9: 222-9. PMID 18241617 DOI: 10.1007/S11883-007-0023-6  1
2007 Gregor MF, Hotamisligil GS. Thematic review series: Adipocyte Biology. Adipocyte stress: the endoplasmic reticulum and metabolic disease. Journal of Lipid Research. 48: 1905-14. PMID 17699733 DOI: 10.1194/Jlr.R700007-Jlr200  1
2007 Liu S, Tinker L, Song Y, Rifai N, Bonds DE, Cook NR, Heiss G, Howard BV, Hotamisligil GS, Hu FB, Kuller LH, Manson JE. A prospective study of inflammatory cytokines and diabetes mellitus in a multiethnic cohort of postmenopausal women. Archives of Internal Medicine. 167: 1676-85. PMID 17698692 DOI: 10.1001/Archinte.167.15.1676  1
2007 Reynolds JM, Liu Q, Brittingham KC, Liu Y, Gruenthal M, Gorgun CZ, Hotamisligil GS, Stout RD, Suttles J. Deficiency of fatty acid-binding proteins in mice confers protection from development of experimental autoimmune encephalomyelitis. Journal of Immunology (Baltimore, Md. : 1950). 179: 313-21. PMID 17579051 DOI: 10.4049/Jimmunol.179.1.313  1
2007 Furuhashi M, Tuncman G, Görgün CZ, Makowski L, Atsumi G, Vaillancourt E, Kono K, Babaev VR, Fazio S, Linton MF, Sulsky R, Robl JA, Parker RA, Hotamisligil GS. Treatment of diabetes and atherosclerosis by inhibiting fatty-acid-binding protein aP2. Nature. 447: 959-65. PMID 17554340 DOI: 10.1038/Nature05844  1
2007 Wellen KE, Fucho R, Gregor MF, Furuhashi M, Morgan C, Lindstad T, Vaillancourt E, Gorgun CZ, Saatcioglu F, Hotamisligil GS. Coordinated regulation of nutrient and inflammatory responses by STAMP2 is essential for metabolic homeostasis. Cell. 129: 537-48. PMID 17482547 DOI: 10.1016/J.Cell.2007.02.049  1
2007 Song Y, Manson JE, Tinker L, Rifai N, Cook NR, Hu FB, Hotamisligil GS, Ridker PM, Rodriguez BL, Margolis KL, Oberman A, Liu S. Circulating levels of endothelial adhesion molecules and risk of diabetes in an ethnically diverse cohort of women. Diabetes. 56: 1898-904. PMID 17389327 DOI: 10.2337/Db07-0250  1
2007 Tong Q, Hotamisligil GS. Developmental biology: cell fate in the mammary gland. Nature. 445: 724-6. PMID 17301782 DOI: 10.1038/445724A  1
2007 Attie AD, Spiegelman BM, Bernlohr DA, Shi Y, Kim JB, Glass CK, O'Rahilly S, Hotamisligil GS, Li P, Muoio DM, Zhang CY, Kadowaki T. Discussion Novartis Foundation Symposium. 286: 6-12.  1
2007 Nicholls DG, Larsson NG, Spiegelman BM, Jacobs HT, Brand MD, Lemasters JJ, Martinou JC, O'Rourke B, Shirihai O, Turnbull DM, Halestrap AP, Schon EA, Giulivi C. Discussion Novartis Foundation Symposium. 287: 208-213.  0.8
2007 Li P, Carling D, Hotamisligil GS, Bernlohr DA, Attie AD, Kim JB, Spiegelman BM. Discussion Novartis Foundation Symposium. 286: 81-85.  1
2006 Hotamisligil GS. Inflammation and metabolic disorders. Nature. 444: 860-7. PMID 17167474 DOI: 10.1038/Nature05485  1
2006 Steinberg GR, Michell BJ, van Denderen BJ, Watt MJ, Carey AL, Fam BC, Andrikopoulos S, Proietto J, Görgün CZ, Carling D, Hotamisligil GS, Febbraio MA, Kay TW, Kemp BE. Tumor necrosis factor alpha-induced skeletal muscle insulin resistance involves suppression of AMP-kinase signaling. Cell Metabolism. 4: 465-74. PMID 17141630 DOI: 10.1016/J.Cmet.2006.11.005  1
2006 Rolph MS, Young TR, Shum BO, Gorgun CZ, Schmitz-Peiffer C, Ramshaw IA, Hotamisligil GS, Mackay CR. Regulation of dendritic cell function and T cell priming by the fatty acid-binding protein AP2. Journal of Immunology (Baltimore, Md. : 1950). 177: 7794-801. PMID 17114450  1
2006 Witczak CA, Hirshman MF, Jessen N, Fujii N, Seifert MM, Brandauer J, Hotamisligil GS, Goodyear LJ. JNK1 deficiency does not enhance muscle glucose metabolism in lean mice. Biochemical and Biophysical Research Communications. 350: 1063-8. PMID 17045576 DOI: 10.1016/J.Bbrc.2006.09.158  1
2006 Tilg H, Hotamisligil GS. Nonalcoholic fatty liver disease: Cytokine-adipokine interplay and regulation of insulin resistance. Gastroenterology. 131: 934-45. PMID 16952562 DOI: 10.1053/J.Gastro.2006.05.054  1
2006 Ozcan U, Yilmaz E, Ozcan L, Furuhashi M, Vaillancourt E, Smith RO, Görgün CZ, Hotamisligil GS. Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes. Science (New York, N.Y.). 313: 1137-40. PMID 16931765 DOI: 10.1126/Science.1128294  1
2006 Bence KK, Delibegovic M, Xue B, Gorgun CZ, Hotamisligil GS, Neel BG, Kahn BB. Neuronal PTP1B regulates body weight, adiposity and leptin action. Nature Medicine. 12: 917-24. PMID 16845389 DOI: 10.1038/Nm1435  1
2006 Shum BO, Mackay CR, Gorgun CZ, Frost MJ, Kumar RK, Hotamisligil GS, Rolph MS. The adipocyte fatty acid-binding protein aP2 is required in allergic airway inflammation. The Journal of Clinical Investigation. 116: 2183-2192. PMID 16841093 DOI: 10.1172/JCI24767  1
2006 Tuncman G, Hirosumi J, Solinas G, Chang L, Karin M, Hotamisligil GS. Functional in vivo interactions between JNK1 and JNK2 isoforms in obesity and insulin resistance. Proceedings of the National Academy of Sciences of the United States of America. 103: 10741-6. PMID 16818881 DOI: 10.1073/Pnas.0603509103  1
2006 Cao H, Maeda K, Gorgun CZ, Kim HJ, Park SY, Shulman GI, Kim JK, Hotamisligil GS. Regulation of metabolic responses by adipocyte/macrophage Fatty Acid-binding proteins in leptin-deficient mice. Diabetes. 55: 1915-22. PMID 16804058 DOI: 10.2337/Db05-1496  1
2006 Tuncman G, Erbay E, Hom X, De Vivo I, Campos H, Rimm EB, Hotamisligil GS. A genetic variant at the fatty acid-binding protein aP2 locus reduces the risk for hypertriglyceridemia, type 2 diabetes, and cardiovascular disease. Proceedings of the National Academy of Sciences of the United States of America. 103: 6970-5. PMID 16641093 DOI: 10.1073/Pnas.0602178103  1
2006 Sankalé JL, Tong Q, Hadigan CM, Tan G, Grinspoon SK, Kanki PJ, Hotamisligil GS. Regulation of adiponectin in adipocytes upon exposure to HIV-1. Hiv Medicine. 7: 268-74. PMID 16630040 DOI: 10.1111/J.1468-1293.2006.00372.X  1
2006 Baumgartl J, Baudler S, Scherner M, Babaev V, Makowski L, Suttles J, McDuffie M, Tobe K, Kadowaki T, Fazio S, Kahn CR, Hotamisligil GS, Krone W, Linton M, Brüning JC. Myeloid lineage cell-restricted insulin resistance protects apolipoproteinE-deficient mice against atherosclerosis. Cell Metabolism. 3: 247-56. PMID 16581002 DOI: 10.1016/J.Cmet.2006.02.010  1
2006 Neels JG, Pandey M, Hotamisligil GS, Samad F. Autoamplification of tumor necrosis factor-alpha: a potential mechanism for the maintenance of elevated tumor necrosis factor-alpha in male but not female obese mice. The American Journal of Pathology. 168: 435-44. PMID 16436658 DOI: 10.2353/Ajpath.2006.050699  1
2006 Tsai J, Tong Q, Hotamisligil GS. Chapter 9 GATA proteins as molecular gatekeepers of adipogenesis Advances in Molecular and Cellular Endocrinology. 5: 173-185,315. DOI: 10.1016/S1569-2566(06)05009-5  1
2006 Baumgartl J, Baudler S, Scherner M, Babaev VR, Makowski L, Suttles J, McDuffie M, Tobe K, Kadowaki T, Fazio S, Kahn CR, Hotamisligil GS, Krone W, Linton MF, Brüning JC. Myeloid lineage cell-restricted insulin resistance protects apolipoproteinE-deficient mice against atherosclerosis (DOI:10.1016/j.cmet.2006.02.010) Cell Metabolism. 3: 469. DOI: 10.1016/J.Cmet.2006.05.008  1
2005 Hotamisligil GS. Role of endoplasmic reticulum stress and c-Jun NH2-terminal kinase pathways in inflammation and origin of obesity and diabetes. Diabetes. 54: S73-8. PMID 16306344 DOI: 10.2337/Diabetes.54.Suppl_2.S73  1
2005 Makowski L, Hotamisligil GS. The role of fatty acid binding proteins in metabolic syndrome and atherosclerosis. Current Opinion in Lipidology. 16: 543-8. PMID 16148539 DOI: 10.1097/01.Mol.0000180166.08196.07  1
2005 Tsai J, Tong Q, Tan G, Chang AN, Orkin SH, Hotamisligil GS. The transcription factor GATA2 regulates differentiation of brown adipocytes. Embo Reports. 6: 879-84. PMID 16082385 DOI: 10.1038/Sj.Embor.7400490  1
2005 Maeda K, Cao H, Kono K, Gorgun CZ, Furuhashi M, Uysal KT, Cao Q, Atsumi G, Malone H, Krishnan B, Minokoshi Y, Kahn BB, Parker RA, Hotamisligil GS. Adipocyte/macrophage fatty acid binding proteins control integrated metabolic responses in obesity and diabetes. Cell Metabolism. 1: 107-19. PMID 16054052 DOI: 10.1016/J.Cmet.2004.12.008  1
2005 Wellen KE, Hotamisligil GS. Inflammation, stress, and diabetes. The Journal of Clinical Investigation. 115: 1111-9. PMID 15864338 DOI: 10.1172/Jci25102  1
2005 Pischon T, Girman CJ, Rifai N, Hotamisligil GS, Rimm EB. Association between dietary factors and plasma adiponectin concentrations in men. The American Journal of Clinical Nutrition. 81: 780-6. PMID 15817852 DOI: 10.1093/Ajcn/81.4.780  1
2005 Makowski L, Brittingham KC, Reynolds JM, Suttles J, Hotamisligil GS. The fatty acid-binding protein, aP2, coordinates macrophage cholesterol trafficking and inflammatory activity. Macrophage expression of aP2 impacts peroxisome proliferator-activated receptor gamma and IkappaB kinase activities. The Journal of Biological Chemistry. 280: 12888-95. PMID 15684432 DOI: 10.1074/jbc.M413788200  1
2005 Tong Q, Tsai J, Tan G, Dalgin G, Hotamisligil GS. Interaction between GATA and the C/EBP family of transcription factors is critical in GATA-mediated suppression of adipocyte differentiation. Molecular and Cellular Biology. 25: 706-15. PMID 15632071 DOI: 10.1128/Mcb.25.2.706-715.2005  1
2004 Ozcan U, Cao Q, Yilmaz E, Lee AH, Iwakoshi NN, Ozdelen E, Tuncman G, Görgün C, Glimcher LH, Hotamisligil GS. Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes. Science (New York, N.Y.). 306: 457-61. PMID 15486293 DOI: 10.1126/Science.1103160  1
2004 Boord JB, Maeda K, Makowski L, Babaev VR, Fazio S, Linton MF, Hotamisligil GS. Combined adipocyte-macrophage fatty acid-binding protein deficiency improves metabolism, atherosclerosis, and survival in apolipoprotein E-deficient mice. Circulation. 110: 1492-8. PMID 15353487 DOI: 10.1161/01.Cir.0000141735.13202.B6  1
2004 Makowski L, Hotamisligil GS. Fatty acid binding proteins--the evolutionary crossroads of inflammatory and metabolic responses. The Journal of Nutrition. 134: 2464S-2468S. PMID 15333743 DOI: 10.1093/Jn/134.9.2464S  1
2004 Schlegel A. Adiponectin and risk of coronary heart disease. Jama. 292: 40; author reply 40. PMID 15238584 DOI: 10.1001/Jama.292.1.40-A  1
2004 Pischon T, Girman CJ, Hotamisligil GS, Rifai N, Hu FB, Rimm EB. Plasma adiponectin levels and risk of myocardial infarction in men. Jama. 291: 1730-7. PMID 15082700 DOI: 10.1001/Jama.291.14.1730  1
2004 Wellen KE, Uysal KT, Wiesbrock S, Yang Q, Chen H, Hotamisligil GS. Interaction of tumor necrosis factor-alpha- and thiazolidinedione-regulated pathways in obesity. Endocrinology. 145: 2214-20. PMID 14764635 DOI: 10.1210/En.2003-1580  1
2004 Pischon T, Hotamisligil GS, Rimm EB. Adiponectin and Risk of Coronary Heart Disease—Reply Jama. 292: 40-40. DOI: 10.1001/Jama.292.1.40-B  1
2003 Hotamisligil GS. Inflammatory pathways and insulin action. International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association For the Study of Obesity. 27: S53-5. PMID 14704746 DOI: 10.1038/Sj.Ijo.0802502  1
2003 Tong Q, Tsai J, Hotamisligil GS. GATA transcription factors and fat cell formation. Drug News & Perspectives. 16: 585-8. PMID 14702139 DOI: 10.1358/Dnp.2003.16.9.829340  1
2003 Wellen KE, Hotamisligil GS. Obesity-induced inflammatory changes in adipose tissue. The Journal of Clinical Investigation. 112: 1785-8. PMID 14679172 DOI: 10.1172/Jci20514  1
2003 Pischon T, Hankinson SE, Hotamisligil GS, Rifai N, Rimm EB. Leisure-time physical activity and reduced plasma levels of obesity-related inflammatory markers. Obesity Research. 11: 1055-64. PMID 12972675 DOI: 10.1038/Oby.2003.145  1
2003 Pischon T, Hankinson SE, Hotamisligil GS, Rifai N, Willett WC, Rimm EB. Habitual dietary intake of n-3 and n-6 fatty acids in relation to inflammatory markers among US men and women. Circulation. 108: 155-60. PMID 12821543 DOI: 10.1161/01.Cir.0000079224.46084.C2  1
2003 Tong Q, Sankalé JL, Hadigan CM, Tan G, Rosenberg ES, Kanki PJ, Grinspoon SK, Hotamisligil GS. Regulation of adiponectin in human immunodeficiency virus-infected patients: relationship to body composition and metabolic indices. The Journal of Clinical Endocrinology and Metabolism. 88: 1559-64. PMID 12679439 DOI: 10.1210/Jc.2002-021600  1
2003 Pischon T, Hotamisligil GS, Rimm EB. Adiponectin: Stability in plasma over 36 hours and within-person variation over 1 year Clinical Chemistry. 49: 650-652. PMID 12651819 DOI: 10.1373/49.4.650  1
2003 Pandey M, Tuncman G, Hotamisligil GS, Samad F. Divergent roles for p55 and p75 TNF-α receptors in the induction of plasminogen activator inhibitor-1 American Journal of Pathology. 162: 933-941. PMID 12598326 DOI: 10.1016/S0002-9440(10)63888-6  1
2003 Maeda K, Uysal KT, Makowski L, Görgün CZ, Atsumi G, Parker RA, Brüning J, Hertzel AV, Bernlohr DA, Hotamisligil GS. Role of the fatty acid binding protein mal1 in obesity and insulin resistance. Diabetes. 52: 300-7. PMID 12540600 DOI: 10.2337/Diabetes.52.2.300  1
2003 Hotamisligil GS. The irresistible biology of resistin Journal of Clinical Investigation. 111: 173-174. PMID 12531870 DOI: 10.1172/Jci17605  1
2002 Hirosumi J, Tuncman G, Chang L, Görgün CZ, Uysal KT, Maeda K, Karin M, Hotamisligil GS. A central role for JNK in obesity and insulin resistance. Nature. 420: 333-6. PMID 12447443 DOI: 10.1038/Nature01137  1
2002 Boord JB, Maeda K, Makowski L, Babaev VR, Fazio S, Linton MF, Hotamisligil GS. Adipocyte fatty acid-binding protein, aP2, alters late atherosclerotic lesion formation in severe hypercholesterolemia Arteriosclerosis, Thrombosis, and Vascular Biology. 22: 1686-1691. PMID 12377750 DOI: 10.1161/01.Atv.0000033090.81345.E6  1
2002 Fisher RM, Hoffstedt J, Hotamisligil GS, Thörne A, Rydén M. Effects of obesity and weight loss on the expression of proteins involved in fatty acid metabolism in human adipose tissue International Journal of Obesity. 26: 1379-1385. PMID 12355335 DOI: 10.1038/Sj.Ijo.0802110  1
2002 Xu H, Teoman Uysal K, David Becherer J, Arner P, Hotamisligil GS. Altered tumor necrosis factor-α (TNF-α) processing in adipocytes and increased expression of transmembrane TNF-α in obesity Diabetes. 51: 1876-1883. PMID 12031976 DOI: 10.2337/Diabetes.51.6.1876  1
2002 Xu H, Hirosumi J, Uysal KT, Guler AD, Hotamisligil GS. Exclusive action of transmembrane TNF alpha in adipose tissue leads to reduced adipose mass and local but not systemic insulin resistance. Endocrinology. 143: 1502-11. PMID 11897709 DOI: 10.1210/Endo.143.4.8715  1
2002 Chiellini C, Bertacca A, Novelli SE, Görgün CZ, Ciccarone A, Giordano A, Xu H, Soukas A, Costa M, Gandini D, Dimitri R, Bottone P, Cecchetti P, Pardini E, Perego L, ... ... Hotamisligil GS, et al. Obesity modulates the expression of haptoglobin in the white adipose tissue via TNFalpha. Journal of Cellular Physiology. 190: 251-8. PMID 11807829 DOI: 10.1002/Jcp.10061  1
2001 Mohamed-Ali V, Flower L, Sethi J, Hotamisligil G, Gray R, Humphries SE, York DA, Pinkney J. β-adrenergic regulation of IL-6 release from adipose tissue: In vivo and in vitro studies Journal of Clinical Endocrinology and Metabolism. 86: 5864-5869. PMID 11739453 DOI: 10.1210/Jcem.86.12.8104  1
2001 Tong Q, Hotamisligil GS. Molecular Mechanisms of Adipocyte Differentiation Reviews in Endocrine and Metabolic Disorders. 2: 349-355. PMID 11725721 DOI: 10.1023/A:1011863414321  1
2001 Fisher RM, Eriksson P, Hoffstedt J, Hotamisligil GS, Thörne A, Rydén M, Hamsten A, Arner P. Fatty acid binding protein expression in different adipose tissue depots from lean and obese individuals Diabetologia. 44: 1268-1273. PMID 11692175 DOI: 10.1007/S001250100643  1
2001 Emanuelli B, Peraldi P, Filloux C, Chavey C, Freidinger K, Hilton DJ, Hotamisligil GS, Obberghen EV. SOCS-3 inhibits insulin signaling and is up-regulated in response to TNF-a in the adipose tissue of obese mice Journal of Biological Chemistry. PMID 11604392 DOI: 10.1074/Jbc.M104602200  1
2001 Xu H, Hotamisligil GS. Signaling pathways utilized by tumor necrosis factor receptor 1 in adipocytes to suppress differentiation Febs Letters. 506: 97-102. PMID 11591379 DOI: 10.1016/S0014-5793(01)02889-7  1
2001 Chu NF, Spiegelman D, Hotamisligil GS, Rifai N, Stampfer M, Rimm EB. Plasma insulin, leptin, and soluble TNF receptors levels in relation to obesity-related atherogenic and thrombogenic cardiovascular disease risk factors among men Atherosclerosis. 157: 495-503. PMID 11472752 DOI: 10.1016/S0021-9150(00)00755-3  1
2001 Makowski L, Boord JB, Maeda K, Babaev VR, Uysal KT, Morgan MA, Parker RA, Suttles J, Fazio S, Hotamisligil GS, Linton MF. Lack of macrophage fatty-acid-binding protein aP2 protects mice deficient in apolipoprotein E against atherosclerosis Nature Medicine. 7: 699-705. PMID 11385507 DOI: 10.1038/89076  1
2001 Way JM, Görgün CZ, Tong Q, Uysal KT, Brown KK, Harrington WW, Oliver WR, Willson TM, Kliewer SA, Hotamisligil GS. Adipose tissue resistin expression is severely suppressed in obesity and stimulated by peroxisome proliferator-activated receptor gamma agonists. The Journal of Biological Chemistry. 276: 25651-3. PMID 11373275 DOI: 10.1074/Jbc.C100189200  1
2001 Chu NF, Spiegelman D, Yu J, Rifai N, Hotamisligil GS, Rimm EB. Plasma leptin concentrations and four-year weight gain among US men International Journal of Obesity. 25: 346-353. PMID 11319631 DOI: 10.1038/sj.ijo.0801549  1
2001 Chu NF, Stampfer MJ, Spiegelman D, Rifai N, Hotamisligil GS, Rimm EB. Dietary and lifestyle factors in relation to plasma leptin concentrations among normal weight and overweight men International Journal of Obesity. 25: 106-114. PMID 11244465 DOI: 10.1038/Sj.Ijo.0801468  1
2001 Emanuelli B, Peraldi P, Filloux C, Chavey C, Freidinger K, Hilton DJ, Hotamisligil GS, Van Obberghen E. SOCS-3 Inhibits Insulin Signaling and Is Up-regulated in Response to Tumor Necrosis Factor-α in the Adipose Tissue of Obese Mice Journal of Biological Chemistry. 276: 47944-47949.  1
2000 Hotamisligil GS. Molecular mechanisms of insulin resistance and the role of the adipocyte International Journal of Obesity. 24: S23-S27. PMID 11126235 DOI: 10.1038/sj/ijo/0801497  1
2000 Chu NF, Spiegelman D, Rifai N, Hotamisligil GS, Rimm EB. Glycemic status and soluble tumor necrosis factor receptor levels in relation to plasma leptin concentrations among normal weight and overweight US men International Journal of Obesity. 24: 1085-1092. PMID 11033975 DOI: 10.1038/Sj.Ijo.0801361  1
2000 Tong Q, Dalgin G, Xu H, Ting CN, Leiden JM, Hotamisligil GS. Function of GATA transcription factors in preadipocyte-adipocyte transition. Science (New York, N.Y.). 290: 134-8. PMID 11021798 DOI: 10.1126/Science.290.5489.134  1
2000 Uysal KT, Scheja L, Wiesbrock SM, Bonner-Weir S, Hotamisligil GS. Improved glucose and lipid metabolism in genetically obese mice lacking aP2 Endocrinology. 141: 3388-3396. PMID 10965911 DOI: 10.1210/Endo.141.9.7637  1
2000 Nisoli E, Briscini L, Giordano A, Tonello C, Wiesbrock SM, Uysal KT, Cinti S, Carruba MO, Hotamisligil GS. Tumor necrosis factor α mediates apoptosis of brown adipocytes and defective brown adipocyte function in obesity Proceedings of the National Academy of Sciences of the United States of America. 97: 8033-8038. PMID 10884431 DOI: 10.1073/Pnas.97.14.8033  1
2000 Sethi JK, Xu H, Uysal KT, Wiesbrock SM, Scheja L, Hotamisligil GS. Characterisation of receptor-specific TNFalpha functions in adipocyte cell lines lacking type 1 and 2 TNF receptors. Febs Letters. 469: 77-82. PMID 10708760 DOI: 10.1016/S0014-5793(00)01250-3  1
2000 Memon RA, Hotamisligil GS, Wiesbrock SM, Uysal KT, Faggioni R, Moser AH, Feingold KR, Grunfeld C. Upregulation of uncoupling protein 2 mRNA in genetic obesity: Lack of an essential role for leptin, hyperphagia, increased tissue lipid content, and TNF-α Biochimica Et Biophysica Acta - Molecular and Cell Biology of Lipids. 1484: 41-50. PMID 10685029 DOI: 10.1016/S1388-1981(99)00195-X  1
2000 Chu N-, Hotamisligil GS, Stampfer M, Rimm EB. Plasma leptin and soluble TNF-receptors levels in relation to atherogenic and thrombogenic CVD risk factors among us men Atherosclerosis. 151: 29. DOI: 10.1016/S0021-9150(00)80131-8  1
1999 Scheja L, Makowski L, Uysal KT, Wiesbrock SM, Shimshek DR, Meyers DS, Morgan M, Parker RA, Hotamisligil GS. Altered insulin secretion associated with reduced lipolytic efficiency in aP2(-/-) mice Diabetes. 48: 1987-1994. PMID 10512363 DOI: 10.2337/Diabetes.48.10.1987  1
1999 Xu H, Sethi JK, Hotamisligil GS. Transmembrane tumor necrosis factor (TNF)-alpha inhibits adipocyte differentiation by selectively activating TNF receptor 1. The Journal of Biological Chemistry. 274: 26287-95. PMID 10473584 DOI: 10.1074/Jbc.274.37.26287  1
1999 Hotamisligil GS. The role of TNFα and TNF receptors in obesity and insulin resistance Journal of Internal Medicine. 245: 621-625. PMID 10395191 DOI: 10.1046/j.1365-2796.1999.00490.x  1
1999 Samad F, Uysal KT, Wiesbrock SM, Pandey M, Hotamisligil GS, Loskutoff DJ. Tumor necrosis factor α is a key component in the obesity-linked elevation of plasminogen activator inhibitor 1 Proceedings of the National Academy of Sciences of the United States of America. 96: 6902-6907. PMID 10359811 DOI: 10.1073/Pnas.96.12.6902  1
1999 Sethi JK, Hotamisligil GS. The role of TNF alpha in adipocyte metabolism. Seminars in Cell & Developmental Biology. 10: 19-29. PMID 10355025 DOI: 10.1006/Scdb.1998.0273  1
1999 Hotamisligil GS. Mechanisms of TNF-α-induced insulin resistance Experimental and Clinical Endocrinology and Diabetes. 107: 119-125. PMID 10320052 DOI: 10.1055/S-0029-1212086  1
1999 Chu NF, Makowski L, Hotamisligil GS, Rimm EB. Stability of human plasma leptin concentrations within 36 hours following specimen collection Clinical Biochemistry. 32: 87-89. PMID 10074899 DOI: 10.1016/S0009-9120(98)00065-4  1
1998 Uysal KT, Wiesbrock SM, Hotamisligil GS. Functional analysis of tumor necrosis factor (TNF) receptors in TNF-α- mediated insulin resistance in genetic obesity Endocrinology. 139: 4832-4838. PMID 9832419 DOI: 10.1210/Endo.139.12.6337  1
1997 Kirchgessner TG, Uysal KT, Wiesbrock SM, Marino MW, Hotamisligil GS. Tumor necrosis factor-α contributes to obesity-related hyperleptinemia by regulating leptin release from adipocytes Journal of Clinical Investigation. 100: 2777-2782. PMID 9389742 DOI: 10.1172/Jci119824  1
1997 Uysal KT, Wiesbrock SM, Marino MW, Hotamisligil GS. Protection from obesity-induced insulin resistance in mice lacking TNF- α function Nature. 389: 610-614. PMID 9335502 DOI: 10.1038/39335  1
1997 Hotamisligil GS, Arner P, Atkinson RL, Spiegelman BM. Differential regulation of the p80 tumor necrosis factor receptor in human obesity and insulin resistance. Diabetes. 46: 451-5. PMID 9032102 DOI: 10.2337/Diab.46.3.451  1
1997 Hotamisligil GS. The cross-talk between insulin and tumour necrosis factor receptors in insulin resistance Endocrinology and Metabolism, Supplement. 4: 151-153.  1
1996 Hotamisligil GS, Johnson RS, Distel RJ, Ellis R, Papaioannou VE, Spiegelman BM. Uncoupling of obesity from insulin resistance through a targeted mutation in aP2, the adipocyte fatty acid binding protein. Science (New York, N.Y.). 274: 1377-9. PMID 8910278 DOI: 10.1126/Science.274.5291.1377  1
1996 Peraldi P, Hotamisligil GS, Buurman WA, White MF, Spiegelman BM. Tumor necrosis factor (TNF)-alpha inhibits insulin signaling through stimulation of the p55 TNF receptor and activation of sphingomyelinase. The Journal of Biological Chemistry. 271: 13018-22. PMID 8662983 DOI: 10.1074/Jbc.271.22.13018  1
1996 Hotamisligil GS, Peraldi P, Budavari A, Ellis R, White MF, Spiegelman BM. IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-alpha- and obesity-induced insulin resistance. Science (New York, N.Y.). 271: 665-8. PMID 8571133 DOI: 10.1126/Science.271.5249.665  1
1996 Hotamisligil GS, Peraldi P, Spiegelman BM. The molecular link between obesity and diabetes Current Opinion in Endocrinology and Diabetes. 3: 16-23. DOI: 10.1097/00060793-199602000-00004  1
1995 Hotamisligil GS, Arner P, Caro JF, Atkinson RL, Spiegelman BM. Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance. The Journal of Clinical Investigation. 95: 2409-15. PMID 7738205 DOI: 10.1172/Jci117936  1
1994 Hofmann C, Lorenz K, Braithwaite SS, Colca JR, Palazuk BJ, Hotamisligil GS, Spiegelman BM. Altered gene expression for tumor necrosis factor-alpha and its receptors during drug and dietary modulation of insulin resistance. Endocrinology. 134: 264-70. PMID 8275942 DOI: 10.1210/endo.134.1.8275942  1
1994 Hotamisligil GS, Murray DL, Choy LN, Spiegelman BM. Tumor necrosis factor alpha inhibits signaling from the insulin receptor. Proceedings of the National Academy of Sciences of the United States of America. 91: 4854-8. PMID 8197147 DOI: 10.1073/Pnas.91.11.4854  1
1994 Hotamisligil GS, Spiegelman BM. Tumor necrosis factor alpha: a key component of the obesity-diabetes link. Diabetes. 43: 1271-8. PMID 7926300 DOI: 10.2337/Diab.43.11.1271  1
1994 Hotamisligil GS, Girmen AS, Fink JS, Tivol E, Shalish C, Trofatter J, Baenziger J, Diamond S, Markham C, Sullivan J. Hereditary variations in monoamine oxidase as a risk factor for Parkinson's disease. Movement Disorders : Official Journal of the Movement Disorder Society. 9: 305-10. PMID 7913737 DOI: 10.1002/Mds.870090304  1
1994 Hotamisligil GS, Budavari A, Murray D, Spiegelman BM. Reduced tyrosine kinase activity of the insulin receptor in obesity-diabetes. Central role of tumor necrosis factor-alpha. The Journal of Clinical Investigation. 94: 1543-9. PMID 7523453 DOI: 10.1172/JCI117495  1
1993 Spiegelman BM, Hotamisligil GS. Through thick and thin: wasting, obesity, and TNF alpha. Cell. 73: 625-7. PMID 8500160 DOI: 10.1016/0092-8674(93)90243-J  1
1993 Spiegelman BM, Choy L, Hotamisligil GS, Graves RA, Tontonoz P. Regulation of adipocyte gene expression in differentiation and syndromes of obesity/diabetes. The Journal of Biological Chemistry. 268: 6823-6. PMID 8463205  1
1993 Hotamisligil GS, Shargill NS, Spiegelman BM. Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. Science (New York, N.Y.). 259: 87-91. PMID 7678183 DOI: 10.1126/Science.7678183  1
1992 Girmen AS, Baenziger J, Hotamisligil GS, Konradi C, Shalish C, Sullivan JL, Breakefield XO. Relationship between platelet monoamine oxidase B activity and alleles at the MAOB locus. Journal of Neurochemistry. 59: 2063-6. PMID 1431894 DOI: 10.1111/J.1471-4159.1992.Tb10095.X  1
1991 Chen ZY, Hotamisligil GS, Huang JK, Wen L, Ezzeddine D, Aydin-Muderrisoglu N, Powell JF, Huang RH, Breakefield XO, Craig I. Structure of the human gene for monoamine oxidase type A. Nucleic Acids Research. 19: 4537-41. PMID 1886775 DOI: 10.1093/Nar/19.16.4537  1
1991 Hotamisligil GS, Breakefield XO. Human monoamine oxidase A gene determines levels of enzyme activity. American Journal of Human Genetics. 49: 383-92. PMID 1678250  1
1990 Hotamisligil GS, Ertogan F. The Proteus syndrome: Association with nephrogenic diabetes insipidus Clinical Genetics. 38: 139-144. PMID 2208765  1
1990 Hotamisligil GS. Proteus syndrome and hamartoses with overgrowth Dysmorphology and Clinical Genetics. 4: 87-102.  1
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