Laura J. Niedernhofer - Publications

Affiliations: 
University of Pittsburgh, Pittsburgh, PA, United States 
Area:
Cell Biology, Molecular Biology, Genetics, Aging

53 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2018 Gurkar AU, Robinson AR, Cui Y, Li X, Allani SK, Webster A, Muravia M, Fallahi M, Weissbach H, Robbins PD, Wang Y, Kelley EE, Croix CMS, Niedernhofer LJ, Gill MS. Dysregulation of DAF-16/FOXO3A-mediated stress responses accelerates oxidative DNA damage induced aging. Redox Biology. 18: 191-199. PMID 30031267 DOI: 10.1016/j.redox.2018.06.005  0.92
2018 Czerwińska J, Nowak M, Wojtczak P, Dziuban-Lech D, Cieśla JM, Kołata D, Gajewska B, Barańczyk-Kuźma A, Robinson AR, Shane HL, Gregg SQ, Rigatti LH, Yousefzadeh MJ, Gurkar AU, McGowan SJ, ... ... Niedernhofer LJ, et al. ERCC1-deficient cells and mice are hypersensitive to lipid peroxidation. Free Radical Biology & Medicine. PMID 29860127 DOI: 10.1016/j.freeradbiomed.2018.05.088  0.92
2018 Robinson AR, Yousefzadeh MJ, Rozgaja TA, Wang J, Li X, Tilstra JS, Feldman CH, Gregg SQ, Johnson CH, Skoda EM, Frantz MC, Bell-Temin H, Pope-Varsalona H, Gurkar AU, Nasto LA, ... ... Niedernhofer LJ, et al. Spontaneous DNA damage to the nuclear genome promotes senescence, redox imbalance and aging. Redox Biology. 17: 259-273. PMID 29747066 DOI: 10.1016/j.redox.2018.04.007  0.92
2018 Zarakowska E, Czerwinska J, Tupalska A, Yousefzadeh MJ, Gregg SQ, St Croix CM, Niedernhofer LJ, Foksinski M, Gackowski D, Szpila A, Starczak M, Tudek B, Olinski R. Oxidation Products of 5-Methyl Cytosine are Decreased in Senescent Cells and Tissues of Progeroid Mice. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. PMID 29415265 DOI: 10.1093/gerona/gly012  0.92
2017 Fuhrmann-Stroissnigg H, Ling YY, Zhao J, McGowan SJ, Zhu Y, Brooks RW, Grassi D, Gregg SQ, Stripay JL, Dorronsoro A, Corbo L, Tang P, Bukata C, Ring N, Giacca M, ... ... Niedernhofer LJ, et al. Identification of HSP90 inhibitors as a novel class of senolytics. Nature Communications. 8: 422. PMID 28871086 DOI: 10.1038/s41467-017-00314-z  0.92
2015 Fu L, Amato NJ, Wang P, McGowan S, Niedernhofer LJ, Wang Y. Simultaneous Quantification of Methylated Cytidine and Adenosine in Cellular and Tissue RNA by Nano-Flow Liquid Chromatography-Tandem Mass Spectrometry Coupled with the Stable Isotope-dilution Method. Analytical Chemistry. PMID 26158405 DOI: 10.1021/acs.analchem.5b00951  0.92
2015 Zhu Y, Tchkonia T, Pirtskhalava T, Gower AC, Ding H, Giorgadze N, Palmer AK, Ikeno Y, Hubbard GB, Lenburg M, O'Hara SP, LaRusso NF, Miller JD, Roos CM, Verzosa GC, ... ... Niedernhofer LJ, et al. The Achilles' heel of senescent cells: from transcriptome to senolytic drugs. Aging Cell. 14: 644-58. PMID 25754370 DOI: 10.1111/acel.12344  0.92
2015 Zhao J, Li X, McGowan S, Niedernhofer LJ, Robbins PD. NF-κB activation with aging: Characterization and therapeutic inhibition Methods in Molecular Biology. 1280: 543-557. PMID 25736771 DOI: 10.1007/978-1-4939-2422-6_32  0.92
2014 Fu L, Guerrero CR, Zhong N, Amato NJ, Liu Y, Liu S, Cai Q, Ji D, Jin SG, Niedernhofer LJ, Pfeifer GP, Xu GL, Wang Y. Tet-mediated formation of 5-hydroxymethylcytosine in RNA. Journal of the American Chemical Society. 136: 11582-5. PMID 25073028 DOI: 10.1021/ja505305z  0.92
2014 Vaezi AE, Bepler G, Bhagwat NR, Malysa A, Rubatt JM, Chen W, Hood BL, Conrads TP, Wang L, Kemp CE, Niedernhofer LJ. Choline phosphate cytidylyltransferase-α is a novel antigen detected by the anti-ERCC1 antibody 8F1 with biomarker value in patients with lung and head and neck squamous cell carcinomas. Cancer. 120: 1898-907. PMID 24692084 DOI: 10.1002/cncr.28643  0.92
2014 Tilstra JS, Gaddy DF, Zhao J, Davé SH, Niedernhofer LJ, Plevy SE, Robbins PD. Pharmacologic IKK/NF-κB inhibition causes antigen presenting cells to undergo TNFα dependent ROS-mediated programmed cell death. Scientific Reports. 4: 3631. PMID 24406986 DOI: 10.1038/srep03631  0.92
2014 Nasto LA, Ngo K, Leme AS, Robinson AR, Dong Q, Roughley P, Usas A, Sowa GA, Pola E, Kang J, Niedernhofer LJ, Shapiro S, Vo NV. Investigating the role of DNA damage in tobacco smoking-induced spine degeneration. The Spine Journal : Official Journal of the North American Spine Society. 14: 416-23. PMID 24211096 DOI: 10.1016/j.spinee.2013.08.034  0.92
2013 Karakasilioti I, Kamileri I, Chatzinikolaou G, Kosteas T, Vergadi E, Robinson AR, Tsamardinos I, Rozgaja TA, Siakouli S, Tsatsanis C, Niedernhofer LJ, Garinis GA. DNA damage triggers a chronic autoinflammatory response, leading to fat depletion in NER progeria. Cell Metabolism. 18: 403-15. PMID 24011075 DOI: 10.1016/j.cmet.2013.08.011  0.92
2013 Roh DS, Du Y, Gabriele ML, Robinson AR, Niedernhofer LJ, Funderburgh JL. Age-related dystrophic changes in corneal endothelium from DNA repair-deficient mice. Aging Cell. 12: 1122-31. PMID 23927039 DOI: 10.1111/acel.12143  0.92
2013 Vo N, Niedernhofer LJ, Nasto LA, Jacobs L, Robbins PD, Kang J, Evans CH. An overview of underlying causes and animal models for the study of age-related degenerative disorders of the spine and synovial joints. Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society. 31: 831-7. PMID 23483579 DOI: 10.1002/jor.22204  0.92
2013 Lavasani M, Lu A, Thompson SD, Robbins PD, Huard J, Niedernhofer LJ. Isolation of muscle-derived stem/progenitor cells based on adhesion characteristics to collagen-coated surfaces. Methods in Molecular Biology (Clifton, N.J.). 976: 53-65. PMID 23400434 DOI: 10.1007/978-1-62703-317-6_5  0.92
2013 Nasto LA, Robinson AR, Ngo K, Clauson CL, Dong Q, St Croix C, Sowa G, Pola E, Robbins PD, Kang J, Niedernhofer LJ, Wipf P, Vo NV. Mitochondrial-derived reactive oxygen species (ROS) play a causal role in aging-related intervertebral disc degeneration. Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society. 31: 1150-7. PMID 23389888 DOI: 10.1002/jor.22320  0.92
2013 Chen Q, Liu K, Robinson AR, Clauson CL, Blair HC, Robbins PD, Niedernhofer LJ, Ouyang H. DNA damage drives accelerated bone aging via an NF-κB-dependent mechanism. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. 28: 1214-28. PMID 23281008 DOI: 10.1002/jbmr.1851  0.92
2013 Nasto LA, Wang D, Robinson AR, Clauson CL, Ngo K, Dong Q, Roughley P, Epperly M, Huq SM, Pola E, Sowa G, Robbins PD, Kang J, Niedernhofer LJ, Vo NV. Genotoxic stress accelerates age-associated degenerative changes in intervertebral discs. Mechanisms of Ageing and Development. 134: 35-42. PMID 23262094 DOI: 10.1016/j.mad.2012.11.002  0.92
2013 Cho JS, Kook SH, Robinson AR, Niedernhofer LJ, Lee BC. Cell autonomous and nonautonomous mechanisms drive hematopoietic stem/progenitor cell loss in the absence of DNA repair. Stem Cells (Dayton, Ohio). 31: 511-25. PMID 23097336 DOI: 10.1002/stem.1261  0.92
2012 Xun Z, Rivera-Sánchez S, Ayala-Peña S, Lim J, Budworth H, Skoda EM, Robbins PD, Niedernhofer LJ, Wipf P, McMurray CT. Targeting of XJB-5-131 to mitochondria suppresses oxidative DNA damage and motor decline in a mouse model of Huntington's disease. Cell Reports. 2: 1137-42. PMID 23122961 DOI: 10.1016/j.celrep.2012.10.001  0.92
2012 You C, Dai X, Yuan B, Wang J, Wang J, Brooks PJ, Niedernhofer LJ, Wang Y. A quantitative assay for assessing the effects of DNA lesions on transcription. Nature Chemical Biology. 8: 817-22. PMID 22902614 DOI: 10.1038/nchembio.1046  0.92
2012 Tilstra JS, Robinson AR, Wang J, Gregg SQ, Clauson CL, Reay DP, Nasto LA, St Croix CM, Usas A, Vo N, Huard J, Clemens PR, Stolz DB, Guttridge DC, Watkins SC, ... ... Niedernhofer LJ, et al. NF-κB inhibition delays DNA damage-induced senescence and aging in mice. The Journal of Clinical Investigation. 122: 2601-12. PMID 22706308 DOI: 10.1172/JCI45785  0.92
2012 Deloia JA, Bhagwat NR, Darcy KM, Strange M, Tian C, Nuttall K, Krivak TC, Niedernhofer LJ. Comparison of ERCC1/XPF genetic variation, mRNA and protein levels in women with advanced stage ovarian cancer treated with intraperitoneal platinum. Gynecologic Oncology. 126: 448-54. PMID 22609620 DOI: 10.1016/j.ygyno.2012.05.006  0.56
2012 Wang J, Cao H, You C, Yuan B, Bahde R, Gupta S, Nishigori C, Niedernhofer LJ, Brooks PJ, Wang Y. Endogenous formation and repair of oxidatively induced G[8-5 m]T intrastrand cross-link lesion. Nucleic Acids Research. 40: 7368-74. PMID 22581771 DOI: 10.1093/nar/gks357  0.92
2012 Su Y, Orelli B, Madireddy A, Niedernhofer LJ, Schärer OD. Multiple DNA binding domains mediate the function of the ERCC1-XPF protein in nucleotide excision repair. The Journal of Biological Chemistry. 287: 21846-55. PMID 22547097 DOI: 10.1074/jbc.M111.337899  0.92
2012 Wang J, Clauson CL, Robbins PD, Niedernhofer LJ, Wang Y. The oxidative DNA lesions 8,5'-cyclopurines accumulate with aging in a tissue-specific manner. Aging Cell. 11: 714-6. PMID 22530741 DOI: 10.1111/j.1474-9726.2012.00828.x  0.92
2012 Nasto LA, Seo HY, Robinson AR, Tilstra JS, Clauson CL, Sowa GA, Ngo K, Dong Q, Pola E, Lee JY, Niedernhofer LJ, Kang JD, Robbins PD, Vo NV. ISSLS prize winner: inhibition of NF-κB activity ameliorates age-associated disc degeneration in a mouse model of accelerated aging. Spine. 37: 1819-25. PMID 22343279 DOI: 10.1097/BRS.0b013e31824ee8f7  0.92
2012 Rubatt JM, Darcy KM, Tian C, Muggia F, Dhir R, Armstrong DK, Bookman MA, Niedernhofer LJ, Deloia J, Birrer M, Krivak TC. Pre-treatment tumor expression of ERCC1 in women with advanced stage epithelial ovarian cancer is not predictive of clinical outcomes: a Gynecologic Oncology Group study. Gynecologic Oncology. 125: 421-6. PMID 22261301 DOI: 10.1016/j.ygyno.2012.01.008  0.56
2012 Smith SC, Robinson AR, Niedernhofer LJ, Hetman M. Downregulation of cholesterol biosynthesis genes in the forebrain of ERCC1-deficient mice. Neurobiology of Disease. 45: 1136-44. PMID 22245387 DOI: 10.1016/j.nbd.2011.12.036  0.92
2012 Lavasani M, Robinson AR, Lu A, Song M, Feduska JM, Ahani B, Tilstra JS, Feldman CH, Robbins PD, Niedernhofer LJ, Huard J. Muscle-derived stem/progenitor cell dysfunction limits healthspan and lifespan in a murine progeria model. Nature Communications. 3: 608. PMID 22215083 DOI: 10.1038/ncomms1611  0.92
2012 Matoka DJ, Yao V, Harya DS, Gregg JL, Robinson AR, Niedernhofer LJ, Parwani AV, Maier C, Bacich DJ. Deficiency of DNA repair nuclease ERCC1-XPF promotes prostate cancer progression in a tissue recombination model. The Prostate. 72: 1214-22. PMID 22212909 DOI: 10.1002/pros.22472  0.92
2012 Lu A, Proto JD, Guo L, Tang Y, Lavasani M, Tilstra JS, Niedernhofer LJ, Wang B, Guttridge DC, Robbins PD, Huard J. NF-κB negatively impacts the myogenic potential of muscle-derived stem cells. Molecular Therapy : the Journal of the American Society of Gene Therapy. 20: 661-8. PMID 22158056 DOI: 10.1038/mt.2011.261  0.92
2012 Gregg SQ, Gutiérrez V, Robinson AR, Woodell T, Nakao A, Ross MA, Michalopoulos GK, Rigatti L, Rothermel CE, Kamileri I, Garinis GA, Stolz DB, Niedernhofer LJ. A mouse model of accelerated liver aging caused by a defect in DNA repair. Hepatology (Baltimore, Md.). 55: 609-21. PMID 21953681 DOI: 10.1002/hep.24713  0.92
2011 Tilstra JS, Clauson CL, Niedernhofer LJ, Robbins PD. NF-κB in Aging and Disease. Aging and Disease. 2: 449-65. PMID 22396894  0.92
2011 Choi S, Wang W, Ribeiro AJ, Kalinowski A, Gregg SQ, Opresko PL, Niedernhofer LJ, Rohde GK, Dahl KN. Computational image analysis of nuclear morphology associated with various nuclear-specific aging disorders. Nucleus (Austin, Tex.). 2: 570-9. PMID 22127259 DOI: 10.4161/nucl.2.6.17798  0.92
2011 Niedernhofer LJ, Glorioso JC, Robbins PD. Dedifferentiation rescues senescence of progeria cells but only while pluripotent. Stem Cell Research & Therapy. 2: 28. PMID 21639955 DOI: 10.1186/scrt69  0.92
2011 Gregg SQ, Robinson AR, Niedernhofer LJ. Physiological consequences of defects in ERCC1-XPF DNA repair endonuclease Dna Repair. 10: 781-791. PMID 21612988 DOI: 10.1016/j.dnarep.2011.04.026  0.92
2011 Goss JR, Stolz DB, Robinson AR, Zhang M, Arbujas N, Robbins PD, Glorioso JC, Niedernhofer LJ. Premature aging-related peripheral neuropathy in a mouse model of progeria. Mechanisms of Ageing and Development. 132: 437-42. PMID 21596054 DOI: 10.1016/j.mad.2011.04.010  0.92
2011 Wang D, Vo NV, Sowa GA, Hartman RA, Ngo K, Choe SR, Witt WT, Dong Q, Lee JY, Niedernhofer LJ, Kang JD. Bupivacaine decreases cell viability and matrix protein synthesis in an intervertebral disc organ model system. The Spine Journal : Official Journal of the North American Spine Society. 11: 139-46. PMID 21296298 DOI: 10.1016/j.spinee.2010.11.017  0.92
2010 Vo N, Seo HY, Robinson A, Sowa G, Bentley D, Taylor L, Studer R, Usas A, Huard J, Alber S, Watkins SC, Lee J, Coehlo P, Wang D, Loppini M, ... ... Niedernhofer LJ, et al. Accelerated aging of intervertebral discs in a mouse model of progeria. Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society. 28: 1600-7. PMID 20973062 DOI: 10.1002/jor.21153  0.92
2010 Hagelstrom RT, Blagoev KB, Niedernhofer LJ, Goodwin EH, Bailey SM. Hyper telomere recombination accelerates replicative senescence and may promote premature aging Proceedings of the National Academy of Sciences of the United States of America. 107: 15768-15773. PMID 20798040 DOI: 10.1073/pnas.1006338107  0.92
2010 Ahmad A, Enzlin JH, Bhagwat NR, Wijgers N, Raams A, Appledoorn E, Theil AF, J Hoeijmakers JH, Vermeulen W, J Jaspers NG, Schärer OD, Niedernhofer LJ. Mislocalization of XPF-ERCC1 nuclease contributes to reduced DNA repair in XP-F patients. Plos Genetics. 6: e1000871. PMID 20221251 DOI: 10.1371/journal.pgen.1000871  0.92
2010 Orelli B, McClendon TB, Tsodikov OV, Ellenberger T, Niedernhofer LJ, Schärer OD. The XPA-binding domain of ERCC1 is required for nucleotide excision repair but not other DNA repair pathways. The Journal of Biological Chemistry. 285: 3705-12. PMID 19940136 DOI: 10.1074/jbc.M109.067538  0.92
2009 Bhagwat N, Olsen AL, Wang AT, Hanada K, Stuckert P, Kanaar R, D'Andrea A, Niedernhofer LJ, McHugh PJ. XPF-ERCC1 participates in the Fanconi anemia pathway of cross-link repair. Molecular and Cellular Biology. 29: 6427-37. PMID 19805513 DOI: 10.1128/MCB.00086-09  0.92
2009 Bhagwat NR, Roginskaya VY, Acquafondata MB, Dhir R, Wood RD, Niedernhofer LJ. Immunodetection of DNA repair endonuclease ERCC1-XPF in human tissue. Cancer Research. 69: 6831-8. PMID 19723666 DOI: 10.1158/0008-5472.CAN-09-1237  0.56
2008 Schumacher B, van der Pluijm I, Moorhouse MJ, Kosteas T, Robinson AR, Suh Y, Breit TM, van Steeg H, Niedernhofer LJ, van Ijcken W, Bartke A, Spindler SR, Hoeijmakers JH, van der Horst GT, Garinis GA. Delayed and accelerated aging share common longevity assurance mechanisms. Plos Genetics. 4: e1000161. PMID 18704162 DOI: 10.1371/journal.pgen.1000161  0.92
2008 Ahmad A, Robinson AR, Duensing A, van Drunen E, Beverloo HB, Weisberg DB, Hasty P, Hoeijmakers JH, Niedernhofer LJ. ERCC1-XPF endonuclease facilitates DNA double-strand break repair. Molecular and Cellular Biology. 28: 5082-92. PMID 18541667 DOI: 10.1128/MCB.00293-08  0.92
2008 Niedernhofer LJ, Robbins PD. Signaling mechanisms involved in the response to genotoxic stress and regulating lifespan. The International Journal of Biochemistry & Cell Biology. 40: 176-80. PMID 18023240 DOI: 10.1016/j.biocel.2007.10.008  0.92
2007 Niedernhofer LJ, Bhagwat N, Wood RD. ERCC1 and non-small-cell lung cancer [8] New England Journal of Medicine. 356: 2538-2540. PMID 17568038  0.92
2007 Jaspers NG, Raams A, Silengo MC, Wijgers N, Niedernhofer LJ, Robinson AR, Giglia-Mari G, Hoogstraten D, Kleijer WJ, Hoeijmakers JH, Vermeulen W. First reported patient with human ERCC1 deficiency has cerebro-oculo-facio-skeletal syndrome with a mild defect in nucleotide excision repair and severe developmental failure. American Journal of Human Genetics. 80: 457-66. PMID 17273966 DOI: 10.1086/512486  0.92
2006 Niedernhofer LJ, Garinis GA, Raams A, Lalai AS, Robinson AR, Appeldoorn E, Odijk H, Oostendorp R, Ahmad A, van Leeuwen W, Theil AF, Vermeulen W, van der Horst GT, Meinecke P, Kleijer WJ, et al. A new progeroid syndrome reveals that genotoxic stress suppresses the somatotroph axis. Nature. 444: 1038-43. PMID 17183314 DOI: 10.1038/nature05456  0.92
2004 Niedernhofer LJ, Odijk H, Budzowska M, van Drunen E, Maas A, Theil AF, de Wit J, Jaspers NG, Beverloo HB, Hoeijmakers JH, Kanaar R. The structure-specific endonuclease Ercc1-Xpf is required to resolve DNA interstrand cross-link-induced double-strand breaks. Molecular and Cellular Biology. 24: 5776-87. PMID 15199134 DOI: 10.1128/MCB.24.13.5776-5787.2004  0.92
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